中国血吸虫病防治杂志最新文献_第2页

[Molluscicidal effect and costs of spraying pyriclobenzuron with drones against Pomacea canaliculata]. [无人机喷施吡氯苯脲对小管Pomacea的杀螺效果及成本]。

Q3 Medicine

中国血吸虫病防治杂志

Pub Date : 2024-11-12 DOI: 10.16250/j.32.1915.2024120

X Zhao, Y Chen, Y Hu, Y Xu, Y Wang, D Lü, C Wan, Y Sun, L Duan, W Wang, S Huang

Objective: To evaluate the molluscicidal effects and costs of spraying 20% suspension concentrate of pyricloben-zuron sulphate (SCPS) with drones against Pomacea canaliculata in paddy environments, so as to provide insights into the extensive applications of pyriclobenzuron against P. canaliculata.Methods: On July 2022, a paddy field was selected from Nanchang City, Jiangxi Province as the study area, and 72 independent rectangular plots measuring 2 m × 1 m were allocated in the study area, with 1 m interval between each plot, and 20 P. canaliculata snails gently placed in each plot. The activity of 25% wettable powder of pyriclobenzuron sulphate (WPPS) by manual spraying at doses of 0.50, 1.00, 2.00 g/m2 and 4.00 g/m2 against P. canaliculata was tested in 54 plots, and manual spraying of 50% wettable powder of niclosamide ethanolamine salt (WPNES) at a dose of 0.10 g/m2 served as a chemical control, while manual spraying of the same volume of clean water served as a blank control, with 9 plots in each group. The activity of SCPS against P. canaliculata was tested in the remaining 18 plots. Based on the molluscicidal tests of WPPS, the molluscicidal effect of SCPS by manual spraying at doses of 0.20, 0.30, 0.40 g/m2 and 0.50 g/m2 against P. canaliculata was evaluated, and manual spraying of WPNES at a dose of 0.10 g/m2 served as a chemical control, while manual spraying of the same volume of clean water served as a blank control, with three plots in each group. On July 2023, 14 paddy fields with a mean living P. canaliculata density of > 5 snails/m2 were selected from Yujiang District, Yingtan City, Jiangxi Province for molluscicidal tests. Based on the molluscicidal effect of pyriclobenzuron against P. canaliculata in plots, the molluscicidal effects of WPPS by manual spraying at doses of 0.25, 0.50 g/m2 and 1.00 g/m2 and manual applications of WPPS at dose of 0.25, 0.50, 1.00 g/m2 and 2.00 g/m2 mixed with soil were tested, and manual spraying of 0.10 g/m2 WPNES served as a chemical control group, while manual spraying of the same volume of clean water served as a blank control, with one paddy field in each group. Based on the effect of pyriclobenzuron against P. canaliculata in plots, the activity of SCPS sprayed with drones at doses of 0.25 g/m2 and 0.50 g/m2 mixed in water at 2 kg/667 m2 and 4 kg/667 m2 was tested against P. canaliculata, and spraying of the same volume of clean water with drones served as a blank control. All P. canaliculata snails were captured 3 days and 7 days following chemical treatment in plots and paddy fields and identified for survival, and the mortality and corrected mortality of P. canaliculata snails were estimated

目的：评价稻田环境下无人机喷洒20%吡啶苯脲悬浮液（SCPS）对小管Pomacea canaliculata的杀螺效果和成本，为吡啶苯脲对小管Pomacea canaliculata的广泛应用提供依据。方法：于2022年7月在江西省南昌市选取一块水田作为研究区，在研究区内设置72块面积为2 m × 1 m的独立矩形样地，样地间距为1 m，每样地轻轻放置20只小管田螺。以0.50、1.00、2.00、4.00 g/m2剂量的25%吡咯苯脲硫酸酯可湿性粉剂（WPPS）为对照，以0.10 g/m2剂量的50%硝氯胺乙醇胺盐可湿性粉剂（WPNES）为化学对照，以相同体积的清水为空白对照，每组9个小区。在剩余的18个样地检测了SCPS对小管小蠊的活性。在本实验的基础上，分别以0.20、0.30、0.40、0.50 g/m2的剂量对小管小蠊进行人工喷洒，并以0.10 g/m2的剂量为化学对照，以相同体积的清水为空白对照，每组设3个小区。2023年7月，在江西省鹰潭市玉江区选取平均活螺密度为50只/m2的14块水田进行灭螺试验。molluscicidal效应的基础上对p . canaliculata pyriclobenzuron情节,wpp的molluscicidal影响手工喷涂在剂量的0.25,0.50 g / m2和1.00 g / m2的wpp和手动应用剂量的0.25,0.50,1.00 g / m2和2.00 g / m2与土壤混合测试,和手动喷涂的0.10 g / m2 WPNES担任化学对照组,而手动喷涂同样体积的干净的水作为一个空白的控制,每组稻田。以吡氯苯脲对小蠊的杀伤效果为基础，以2 kg/667 m2和4 kg/667 m2的水为对照，分别以0.25 g/m2和0.50 g/m2剂量的无人机喷洒SCPS对小蠊的杀伤活性进行了试验，并以相同体积的清水作为空白对照。在化学处理后第3天和第7天分别在田块和水田中捕获钉螺，鉴定钉螺的存活率，并估计钉螺的死亡率和校正死亡率。此外，估算了水田杀螺试验中化学处理面积、杀螺剂用量和化学处理人工成本，计算了无人机和人工对667 m2面积的化学处理成本。结果：喷施0.50、1.00、2.00 g/m2、4.00 g/m2 WPPS 3 d、7 d钉螺死亡率均为100%，不同剂量scpps处理后3 d钉螺死亡率分别为66.67% ~ 100.00% （χ2 = 277.897, P < 0.05）和76.67% ~ 100.00% （χ2 = 274.206, P < 0.05）。不同剂量WPPS处理稻田钉螺3 d后，钉螺死亡率为98.19% ~ 100.00%。WPPS处理组与对照组小管螺蛳死亡率差异有统计学意义（χ2 = 270.778, P < 0.05）， WPPS处理组与化学对照组之间差异无统计学意义（P值均为0.05），WPPS处理组与空白对照组之间小管螺蛳死亡率差异有统计学意义（P值均< 0.05）。不同剂量无尾蜂喷施SCPS处理3 d后，小管螺蛳死亡率为89.83% ~ 95.31%，SCPS处理组与空白对照组小管螺蛳死亡率差异有统计学意义（χ2 = 1 132.892, P < 0.05）。SCPS处理组和水混合物处理组间小管螺蛳死亡率无显著差异（P值均为0.05），SCPS处理组与空白对照组间小管螺蛳死亡率差异显著（P值均< 0.05）。不同剂量无人机喷洒SCPS处理7 d后，小管螺蛳死亡率为94.62% ~ 100.00%，SCPS处理组与空白对照组的小管螺蛳死亡率差异有统计学意义（χ2 = 1 266.932, P < 0.05），其中以无人机在2 kg/667 m2水中喷洒0.50 g/m2 SCPS组死亡率最高（P < 0.05）。P的成本。

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引用次数: 0

[Application of drones in Oncomelania hupensis snail control with molluscicides]. [无人机在钉螺灭螺中的应用]。

Q3 Medicine

中国血吸虫病防治杂志

Pub Date : 2024-11-11 DOI: 10.16250/j.32.1915.2024188

Y Huang

Oncomelania hupensis snail control by chemical treatment is an important approach for control and elimination of snails, and an appropriate apparatus for spraying chemicals is an important support to molluscicidal effects. Nevertheless, the research and evaluation of molluscicidal apparatuses have not been paid high attention in the schistosomiasis control programme for a long period of time. Currently, agricultural plant-protective apparatuses have been widely used for chemical treatment. This comment provides a short overview of the application of drones in O. hupensis snail control by chemical treatment, and proposes suggestions for solving the problems of use of drones in O. hupensis snail control by chemical treatment in China.

化学防治钉螺是控制和消灭钉螺的重要手段，适宜的药剂喷洒装置是实现杀螺效果的重要保障。然而，长期以来，在血吸虫病防治规划中，杀螺器具的研究和评价没有得到高度重视。目前，农业植保器具已广泛应用于化学处理。本文综述了无人机在化学法防治湖北钉螺中的应用，并针对目前国内无人机在化学法防治湖北钉螺中应用存在的问题提出了建议。

引用次数: 0

[Hepatic T cell subtypes and functional analysis among alveolar echinococcosis patients using single-cell RNA sequencing]. [利用单细胞RNA测序分析肺泡包虫病患者肝T细胞亚型及功能]。

Q3 Medicine

中国血吸虫病防治杂志

Pub Date : 2024-11-08 DOI: 10.16250/j.32.1915.2024172

S Chen, X Wang, W Jia, Q Cai, X Zhang, Q Zhang, H Zheng, L Zhu, B Li, W Wang, X Han

Objective: To investigate T cell subtypes and their functions in liver immune microenvironments among patients with alveolar echinococcosis (AE) using single-cell RNA sequencing (scRNA-seq).Methods: Four AE patients that were admitted to Qinghai Provincial People's Hospital in 2023 for hepatic surgery for the first time were enrolled, and liver specimens were sampled 1 cm (peri-lesion, PL group) and > 5 cm from AE lesions (distal lesion, DL group) among each patient. Finally, a total of eight liver specimens were sampled from four AE patients for scRNA-seq analysis. Genome and transcriptome data of liver specimens were processed using the software Cell Ranger and R package. Differentially expressed genes (DEGs) and their biological functions were analyzed using gene ontology (GO) enrichment analysis and Kyoto encyclopedia of genes and genomes (KEGG) pathway analysis, and the primary intercellular communication patterns and interaction mechanisms were identified among T cell subtypes in liver specimens using the CellChat package. In addition, the developmental stages of T cells were subjected to trajectory analysis with the monocle package to investigate the expression of genes associated with cell growth and tumor transformation, and to predict the developmental trajectories of T cells.Results: All four AE patients were female, with a mean age of (25.00 ± 9.06) years, and there were three cases from Jiuzhi County, Golog Tibetan Autonomous Prefecture and one case from Chengduo County, Yushu Tibetan Autonomous Prefecture, Qinghai Province. The viability of single-cell samples from eight liver specimens was 90.41% to 96.33%, and a total of 81 763 cells were analyzed, with 19 cell types annotated. Of these cell types, 13 were immune cells (87.60%), and T cells (33.13%), neutrophils (15.40%), and natural killer cells (11.92%) were the three most common cell types. Re-clustering of 27 752 T cells and proliferative T cells identified 10 distinct T cell subtypes, with CD8+ cytotoxic T cells (23.43%), CD8+ naive T cells (12.80%), and CD4+ effector memory T cells (17.73%) as dominant cell types. The proportions of T helper 2 (Th2) cells (5.19% vs. 3.63%; χ2 = 38.35, P < 0.01) and CD4+ effector memory T cells (21.59% vs. 13.67%; χ2 = 244.70, P < 0.01) were significantly higher in liver specimens in the PL group than in the DL group, and the proportion of CD4+ helper T cells was significantly lower in the PL group than in the DL group (7.50% vs. 14.75%; χ2 = 330.52, P < 0.01). KEGG pathway analysis revealed that Th2 cells were significantly enriched in cell apoptosis and multiple cancer-associated pathways, and CD4+ effector memory T cells were significantly enriched in the regulation of cytokines and chronic inflammation, while CD4+ helper T cells were significa

目的：应用单细胞RNA测序技术（scRNA-seq）研究肺泡包虫病（AE）患者肝脏免疫微环境中T细胞亚型及其功能。方法：选取2023年首次在青海省人民医院接受肝脏外科手术的4例AE患者，每例患者取离AE病变1 cm（病灶周围，PL组）和50 cm（远端病变，DL组）的肝脏标本。最后，从4例AE患者中共采集8个肝脏标本进行scRNA-seq分析。使用Cell Ranger软件和R软件包处理肝脏标本的基因组和转录组数据。利用基因本体（GO）富集分析和京都基因与基因组百科全书（KEGG）通路分析分析差异表达基因（DEGs）及其生物学功能，并利用CellChat软件包鉴定肝脏标本中T细胞亚型间的主要细胞间通讯模式和相互作用机制。此外，利用单片包对T细胞的发育阶段进行轨迹分析，研究细胞生长和肿瘤转化相关基因的表达，预测T细胞的发育轨迹。结果：4例AE患者均为女性，平均年龄（25.00±9.06）岁，其中3例来自果洛藏族自治州九治县，1例来自玉树藏族自治州成多县。8份肝脏标本的单细胞存活率为90.41% ~ 96.33%，共分析81 763个细胞，注释了19种细胞类型。其中免疫细胞13种（87.60%），T细胞（33.13%）、中性粒细胞（15.40%）和自然杀伤细胞（11.92%）是最常见的3种细胞类型。对27752个T细胞和增殖T细胞进行重新聚类，鉴定出10种不同的T细胞亚型，其中CD8+细胞毒性T细胞（23.43%）、CD8+幼稚T细胞（12.80%）和CD4+效应记忆T细胞（17.73%）为优势细胞类型。辅助性T 2 （Th2）细胞比例(5.19% vs. 3.63%；χ2 = 38.35, P < 0.01)和CD4+效应记忆T细胞(21.59% vs. 13.67%；χ2 = 244.70, P < 0.01)， PL组肝脏标本CD4+辅助性T细胞比例显著低于DL组(7.50%∶14.75%；χ2 = 330.52, p < 0.01)。KEGG通路分析发现，Th2细胞在细胞凋亡和多种癌症相关通路中显著富集，CD4+效应记忆T细胞在细胞因子和慢性炎症的调节中显著富集，CD4+辅助T细胞在免疫应答调节中显著富集。T细胞的轨迹分析显示，CD4+辅助性T细胞相对于Th2细胞和CD4+效应记忆T细胞处于更早的发育阶段，DNA结合抑制剂3 （ID3）、硫氧还蛋白相互作用蛋白（TXNIP）、bcl2相关的无氧基因3 （BAG3）和热休克蛋白家族B（小）成员1 （HSPB1）基因的表达随时间的推移呈现下降趋势。结论：CD4+效应记忆T细胞和CD8+细胞毒性T细胞是AE患者肝脏标本中主要的相互作用细胞。Th2细胞和CD4+辅助性T细胞的表达降低导致免疫微环境的抑制，促进多房棘球蚴的免疫逃避，并且Th2细胞在多种癌症相关通路中显著富集，这可能与多房棘球蚴的侵袭性生长有关。

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引用次数: 0

[Spatio-temporal distribution characteristics of Oncomelania hupensis snails spread in Suzhou City of Jiangsu Province from 2016 to 2023]. [2016 - 2023年江苏省苏州市钉螺传播时空分布特征]。

Q3 Medicine

中国血吸虫病防治杂志

Pub Date : 2024-11-07 DOI: 10.16250/j.32.1915.2024155

Q Shi, L Shen, J Zhou, J Wu

Objective: To investigate the Oncomelania hupensis snails spread and its spatio-temporal clustering characteristics in Suzhou City, Jiangsu Province from 2016 to 2023, so as to provide insights into precision control of O. hupensis snails in the City.

Methods: O. hupensis snail surveillance data in Suzhou City from 2016 to 2023 were collected, and the areas of O. hupensis snail spread and areas of emerging and re-emerging snail habitats were retrieved. The spatial distribution characteristics and clustering types and locations of environments with O. hupensis snail spread were investigated using global and local spatial auto correlation analyses with the software ArcGIS 10.7, and the clustering and cluster areas of O. hupensis snail spread were identified in Suzhou City using spatio-temporal scans with the software SaTScan 10.0.2.

Results: O. hupensis snail spread covered an area of 677 171 m² in Suzhou City from 2016 to 2023, including 376 230 m² emerging snail habitats and 300 941 m² re-emerging snail habitats. Global spatial autocorrelation analysis showed overall clustering of O. hupensis snail spread in Suzhou City from 2016 to 2023 (Moran's I = 0.066, P = 0.007), and there were spatial clustering of areas with O. hupensis snail spread in 2019 (Moran's I = 0.086, P = 0.001) and 2021 (Moran's I = 0.045, P = 0.003). Local spatial autocorrelation analysis showed clusters of O. hupensis snail spread in Suzhou City from 2016 to 2023, with high-high clusters in Guangfu Township and Dongzhu Street, and the high-high clusters of O. hupensis snail spread were mainly distributed in southwestern Suzhou City. Spatio-temporal scans identified two clusters of areas with O. hupensis snail spread and areas of re-emerging snail habitats in Suzhou City from 2016 to 2023, with large clustering areas found in Guangfu Township, Dongzhu Street, Tong'an Township and Wangting Township [relative risk (RR) = 22.34, log likelihood ratio (LLR) = 163 295.32, P < 0.001] and small clustering areas in Xukou Township, Mudu Township and Xiangshan Street (RR = 2.73, LLR = 921.92, P < 0.001).

Conclusions: There was spatial clustering of O. hupensis snail spread in Suzhou City from 2016 to 2023. Improved quality of O. hupensis snail control and intensified management of environments at a high risk of O. hupensis snail spread are recommended in Suzhou City.

目的：了解2016 - 2023年苏州市钉螺分布及时空聚类特征，为苏州市钉螺精准防控提供依据。方法：收集2016 - 2023年苏州市钉螺监测资料，检索苏州市钉螺流行区、新出现和再出现钉螺生境区。利用ArcGIS 10.7软件进行全局和局部空间自相关分析，调查苏州市钉螺传播环境的空间分布特征、聚类类型和分布位置；利用SaTScan 10.0.2软件进行时空扫描，确定苏州市钉螺传播的聚类和聚类区域。结果：2016 - 2023年苏州市钉螺传播面积为677 171 m2，其中新出现钉螺栖息地376 230 m2，再出现钉螺栖息地300 941 m2。全球空间自相关分析显示，2016 - 2023年苏州市钉螺传播总体呈聚类（Moran’s I = 0.066, P = 0.007）， 2019年（Moran’s I = 0.086, P = 0.001）和2021年（Moran’s I = 0.045, P = 0.003）钉螺传播区域呈空间聚类。局部空间自相关分析显示，2016 - 2023年苏州市湖北钉螺传播呈聚集性分布，高-高聚集在广府乡和东渚街，高-高聚集型主要分布在苏州市西南部。时空扫描结果显示，2016 - 2023年苏州市有2个钉螺传播区和钉螺再出现区，其中大聚集区在广福乡、东珠街、同安乡和望亭乡[相对危险度(RR) = 22.34，对数似然比(LLR) = 163 295.32, P < 0.001]，小聚集区在徐口乡、木都乡和象山街[RR = 2.73, LLR = 921.92, P < 0.001]。结论：2016 - 2023年苏州市钉螺传播存在空间聚集性。建议提高苏州市钉螺控制质量，加强钉螺传播高风险环境管理。

{"title":"[Spatio-temporal distribution characteristics of Oncomelania hupensis snails spread in Suzhou City of Jiangsu Province from 2016 to 2023].","authors":"Q Shi, L Shen, J Zhou, J Wu","doi":"10.16250/j.32.1915.2024155","DOIUrl":"https://doi.org/10.16250/j.32.1915.2024155","url":null,"abstract":"Objective: To investigate the Oncomelania hupensis snails spread and its spatio-temporal clustering characteristics in Suzhou City, Jiangsu Province from 2016 to 2023, so as to provide insights into precision control of O. hupensis snails in the City.Methods: O. hupensis snail surveillance data in Suzhou City from 2016 to 2023 were collected, and the areas of O. hupensis snail spread and areas of emerging and re-emerging snail habitats were retrieved. The spatial distribution characteristics and clustering types and locations of environments with O. hupensis snail spread were investigated using global and local spatial auto correlation analyses with the software ArcGIS 10.7, and the clustering and cluster areas of O. hupensis snail spread were identified in Suzhou City using spatio-temporal scans with the software SaTScan 10.0.2.Results: O. hupensis snail spread covered an area of 677 171 m2 in Suzhou City from 2016 to 2023, including 376 230 m2 emerging snail habitats and 300 941 m2 re-emerging snail habitats. Global spatial autocorrelation analysis showed overall clustering of O. hupensis snail spread in Suzhou City from 2016 to 2023 (Moran's I = 0.066, P = 0.007), and there were spatial clustering of areas with O. hupensis snail spread in 2019 (Moran's I = 0.086, P = 0.001) and 2021 (Moran's I = 0.045, P = 0.003). Local spatial autocorrelation analysis showed clusters of O. hupensis snail spread in Suzhou City from 2016 to 2023, with high-high clusters in Guangfu Township and Dongzhu Street, and the high-high clusters of O. hupensis snail spread were mainly distributed in southwestern Suzhou City. Spatio-temporal scans identified two clusters of areas with O. hupensis snail spread and areas of re-emerging snail habitats in Suzhou City from 2016 to 2023, with large clustering areas found in Guangfu Township, Dongzhu Street, Tong'an Township and Wangting Township [relative risk (RR) = 22.34, log likelihood ratio (LLR) = 163 295.32, P < 0.001] and small clustering areas in Xukou Township, Mudu Township and Xiangshan Street (RR = 2.73, LLR = 921.92, P < 0.001).Conclusions: There was spatial clustering of O. hupensis snail spread in Suzhou City from 2016 to 2023. Improved quality of O. hupensis snail control and intensified management of environments at a high risk of O. hupensis snail spread are recommended in Suzhou City.","PeriodicalId":38874,"journal":{"name":"中国血吸虫病防治杂志","volume":"36 6","pages":"577-583"},"PeriodicalIF":0.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Impact of patient-centered care services on the treatment compliance among patients with multidrug-resistant or rifampicin-resistant pulmonary tuberculosis]. [以患者为中心的护理服务对耐多药或利福平耐药肺结核患者治疗依从性的影响]。

Q3 Medicine

中国血吸虫病防治杂志

Pub Date : 2024-11-04 DOI: 10.16250/j.32.1915.2023164

J Pan, H Zhou, L Qian, L Zhu, Q Liu

Objective: To examine the effect of patient-centered care services on compliance to treatment among patients with multidrug-resistant (MDR) or rifampicin-resistant (RR) pulmonary tuberculosis (PTB), so as to provide the scientific evidence for promoting the widespread application of the appropriate nursing process of MDR/RR-PTB patients in the hospital.

Methods: The MDR/RR-PTB patients that were definitely diagnosed at the Sixth People's Hospital of Nantong City during the period from January 2017 to October 2020 were enrolled. The patients with confirmed diagnosis of MDR/RR-PTB during the period January 2017 to December 2018 served as controls, who were given routine care in the hospital, and those with confirmed diagnosis of MDR/RR-PTB during the period January 2019 to October 2020 served as the care group, who were given patient-centered personalized care services, including one-to-one consultations, periodic group activities, informatization case management, and personal reminder for return visits. The proportion of inclusion into treatment, loss to follow-up, return visits and sputum examinations were compared between the care and control groups.

Results: A total of 104 MDR/RR-PTB patients were included, including 54 cases in the control group and 50 cases in the care group. There was no significant difference in gender and age distribution between the two groups (χ² = 3.013, 1.336, P > 0.05). The proportion of inclusion into treatment was higher in the care group (100.00%, 50/50) than in the control group (87.04%, 47/54) (P = 0.013), and the proportion of loss to follow-up was lower in the care group (0, 0/43) than in the control group (19.05%, 8/42) (P = 0.002). In addition, the overall proportion of return visits was higher in the care group (93.09%, 377/405) than in the control group (83.56%, 371/444) (χ² = 18.345, P < 0.001), and the proportion of sputum examinations was higher in the care group was (83.70%, 339/405) than in the control group (79.28%, 352/444) (χ² = 2.737, P = 0.098).

Conclusions: Patient-centered care services facilitate the improvements in the proportion of inclusion into treatment and compliance to treatment and reduction in the proportion of loss to follow-up among MDR/RR-PTB patients, which deserves widespread applications.

目的：探讨以患者为中心的护理服务对耐多药（MDR）或耐利福平（RR）肺结核（PTB）患者治疗依从性的影响，为促进MDR/RR-PTB患者适当护理流程在医院的广泛应用提供科学依据。方法：选取2017年1月至2020年10月在南通市第六人民医院确诊的MDR/RR-PTB患者。将2017年1月至2018年12月确诊为MDR/RR-PTB的患者作为对照组，在医院进行常规护理；将2019年1月至2020年10月确诊为MDR/RR-PTB的患者作为护理组，对其进行以患者为中心的个性化护理服务，包括一对一会诊、定期小组活动、信息化病例管理、个人回访提醒等。比较护理组和对照组的纳入治疗比例、随访失踪率、复诊率和痰液检查率。结果：共纳入104例MDR/RR-PTB患者，其中对照组54例，治疗组50例。两组患者性别、年龄分布差异无统计学意义（χ2 = 3.013, 1.336, P < 0.05）。护理组纳入治疗的比例（100.00%,50/50）高于对照组（87.04%,47/54）（P = 0.013），失访率（0,0 /43）低于对照组（19.05%,8/42）（P = 0.002）。护理组患者复诊总比例（93.09%,377/405）高于对照组（83.56%,371/444）（χ2 = 18.345, P < 0.001），痰液检查比例（83.70%,339/405）高于对照组（79.28%,352/444）（χ2 = 2.737, P = 0.098）。结论：以患者为中心的护理服务有助于提高MDR/RR-PTB患者纳入治疗比例和治疗依从性，降低失访比例，值得广泛推广。

{"title":"[Impact of patient-centered care services on the treatment compliance among patients with multidrug-resistant or rifampicin-resistant pulmonary tuberculosis].","authors":"J Pan, H Zhou, L Qian, L Zhu, Q Liu","doi":"10.16250/j.32.1915.2023164","DOIUrl":"https://doi.org/10.16250/j.32.1915.2023164","url":null,"abstract":"Objective: To examine the effect of patient-centered care services on compliance to treatment among patients with multidrug-resistant (MDR) or rifampicin-resistant (RR) pulmonary tuberculosis (PTB), so as to provide the scientific evidence for promoting the widespread application of the appropriate nursing process of MDR/RR-PTB patients in the hospital.Methods: The MDR/RR-PTB patients that were definitely diagnosed at the Sixth People's Hospital of Nantong City during the period from January 2017 to October 2020 were enrolled. The patients with confirmed diagnosis of MDR/RR-PTB during the period January 2017 to December 2018 served as controls, who were given routine care in the hospital, and those with confirmed diagnosis of MDR/RR-PTB during the period January 2019 to October 2020 served as the care group, who were given patient-centered personalized care services, including one-to-one consultations, periodic group activities, informatization case management, and personal reminder for return visits. The proportion of inclusion into treatment, loss to follow-up, return visits and sputum examinations were compared between the care and control groups.Results: A total of 104 MDR/RR-PTB patients were included, including 54 cases in the control group and 50 cases in the care group. There was no significant difference in gender and age distribution between the two groups (χ2 = 3.013, 1.336, P > 0.05). The proportion of inclusion into treatment was higher in the care group (100.00%, 50/50) than in the control group (87.04%, 47/54) (P = 0.013), and the proportion of loss to follow-up was lower in the care group (0, 0/43) than in the control group (19.05%, 8/42) (P = 0.002). In addition, the overall proportion of return visits was higher in the care group (93.09%, 377/405) than in the control group (83.56%, 371/444) (χ2 = 18.345, P < 0.001), and the proportion of sputum examinations was higher in the care group was (83.70%, 339/405) than in the control group (79.28%, 352/444) (χ2 = 2.737, P = 0.098).Conclusions: Patient-centered care services facilitate the improvements in the proportion of inclusion into treatment and compliance to treatment and reduction in the proportion of loss to follow-up among MDR/RR-PTB patients, which deserves widespread applications.","PeriodicalId":38874,"journal":{"name":"中国血吸虫病防治杂志","volume":"36 5","pages":"494-501"},"PeriodicalIF":0.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Molluscicidal effect of spraying 5% niclosamide ethanolamine salt granules with drones against Oncomelania hupensis in marshland areas]. [无人机喷洒5%氯硝柳胺乙醇胺盐颗粒对沼泽地区湖北钉螺的杀螺效果]。

Q3 Medicine

中国血吸虫病防治杂志

Pub Date : 2024-10-24 DOI: 10.16250/j.32.1915.2024115

C Cao, J Zhang, Y Li, X Shen, J He, Z Bao, S Guo, K Yang, J Xu, S Li, X Zhou

Objective: To evaluate the molluscicidal effect of spraying 5% niclosamide ethanolamine salt granules with drones against of Oncomelania hupensis snails in snail habitats in marshland areas.

Methods: From September to October, 2022, marshlands were sampled from Dantu District, Zhenjiang City, Jiangsu Province as study areas, and assigned into four groups, of approximately 3 000 m² per group. In Group A, environmental cleaning was performed, followed by spraying 5% niclosamide ethanolamine salt granules with knapsack sprayers at a dose of 40 g/m², and in Group B, 5% niclosamide ethanolamine salt granules were sprayed with knapsack sprayers at a dose of 40 g/m² without environmental cleaning, while in Group C, environmental cleaning was conducted, followed by spraying 5% niclosamide ethanolamine salt granules with drones at a dose of 40 g/m², and in Group D, 5% niclosamide ethanolamine salt granules were sprayed with drones at a dose of 40 g/m² without environmental cleaning. Then, the study areas in each group were equally divided into six blocks, with Block 1 for baseline surveys and blocks 2 to 6 for snail surveys 1, 3, 5, 7, 14 days following chemical treatment. The mortality of snails and the reduction of the density of living snails were calculated.

Results: A total of 132 frames were surveyed during the period from September to October 2022, and the occurrence of frames with living snails and means density of living snails were 61.36% (81/132) and 1.58 snails/0.1 m², respectively. The overall mortality rates of snails were 43.02% (77/179), 38.69% (77/199), 47.78% (86/180) and 31.02% (58/187) 14 days following chemical treatment in groups A, B, C and D, respectively (χ² = 11.646, P < 0.05), and there were differences detected in the snail mortality between group A and D, and between groups C and D (both P_adjusted values < 0.05). The adjusted mortality rates of snails were 37.42%, 36.07%, 38.85% and 40.40% in groups A, B, C and D 14 days post-treatment, and the density of living snails decreased by 48.10%, 63.29%, 67.09% and 69.62% 14 days post-treatment relative to pre-treatment, respectively.

Conclusions: Chemical treatment with drones is feasible for O. hupensis snail control in marshland areas; however, the molluscicidal effect of spraying 5% niclosamide ethanolamine salt granules with drones is comparable to spraying chemicals manually in marshland areas regardless of environmental cleaning.

目的：评价无人机喷施5%氯硝柳胺乙醇胺盐颗粒对沼泽钉螺栖息地钉螺的杀螺效果。方法：于2022年9 - 10月在江苏省镇江市丹徒区抽取湿地作为研究区，将湿地分为4组，每组面积约3000 m2。A组进行环境清洗，然后用背负式喷雾器喷洒5%氯硝胺乙醇胺盐颗粒，剂量为40 g/m2； B组用背负式喷雾器喷洒5%氯硝胺乙醇胺盐颗粒，剂量为40 g/m2，不进行环境清洗；C组进行环境清洗，然后用无人机喷洒5%氯硝胺乙醇胺盐颗粒，剂量为40 g/m2；5%氯硝胺乙醇胺盐颗粒剂，无人机喷施剂量为40 g/m2，不进行环境清洗。然后，将每组的研究区域平均分为6个区块，第1区块用于基线调查，第2至6区块用于化学处理后1、3、5、7、14天的蜗牛调查。计算钉螺死亡率及钉螺活密度降低率。结果：2022年9 - 10月共调查蝇框132个，蝇框活螺发生率为61.36%(81/132)，平均活螺密度为1.58只/0.1 m2。A、B、C、D组钉螺总死亡率分别为43.02%（77/179）、38.69%（77/199）、47.78%（86/180）、31.02% (58/187)(χ2 = 11.646, P < 0.05)， A、D组、C、D组钉螺总死亡率差异有统计学意义（P校正值均< 0.05）。处理14 D后，A、B、C、D组钉螺校正死亡率分别为37.42%、36.07%、38.85%、40.40%，钉螺活密度分别比处理前降低48.10%、63.29%、67.09%、69.62%。结论：无人机化学处理在沼泽地区防治湖北钉螺是可行的；然而，在不考虑环境清洁的沼泽地地区，无人机喷洒5%氯硝柳胺乙醇胺盐颗粒的杀螺效果与人工喷洒化学品相当。

{"title":"[Molluscicidal effect of spraying 5% niclosamide ethanolamine salt granules with drones against Oncomelania hupensis in marshland areas].","authors":"C Cao, J Zhang, Y Li, X Shen, J He, Z Bao, S Guo, K Yang, J Xu, S Li, X Zhou","doi":"10.16250/j.32.1915.2024115","DOIUrl":"https://doi.org/10.16250/j.32.1915.2024115","url":null,"abstract":"Objective: To evaluate the molluscicidal effect of spraying 5% niclosamide ethanolamine salt granules with drones against of Oncomelania hupensis snails in snail habitats in marshland areas.Methods: From September to October, 2022, marshlands were sampled from Dantu District, Zhenjiang City, Jiangsu Province as study areas, and assigned into four groups, of approximately 3 000 m2 per group. In Group A, environmental cleaning was performed, followed by spraying 5% niclosamide ethanolamine salt granules with knapsack sprayers at a dose of 40 g/m2, and in Group B, 5% niclosamide ethanolamine salt granules were sprayed with knapsack sprayers at a dose of 40 g/m2 without environmental cleaning, while in Group C, environmental cleaning was conducted, followed by spraying 5% niclosamide ethanolamine salt granules with drones at a dose of 40 g/m2, and in Group D, 5% niclosamide ethanolamine salt granules were sprayed with drones at a dose of 40 g/m2 without environmental cleaning. Then, the study areas in each group were equally divided into six blocks, with Block 1 for baseline surveys and blocks 2 to 6 for snail surveys 1, 3, 5, 7, 14 days following chemical treatment. The mortality of snails and the reduction of the density of living snails were calculated.Results: A total of 132 frames were surveyed during the period from September to October 2022, and the occurrence of frames with living snails and means density of living snails were 61.36% (81/132) and 1.58 snails/0.1 m2, respectively. The overall mortality rates of snails were 43.02% (77/179), 38.69% (77/199), 47.78% (86/180) and 31.02% (58/187) 14 days following chemical treatment in groups A, B, C and D, respectively (χ2 = 11.646, P < 0.05), and there were differences detected in the snail mortality between group A and D, and between groups C and D (both Padjusted values < 0.05). The adjusted mortality rates of snails were 37.42%, 36.07%, 38.85% and 40.40% in groups A, B, C and D 14 days post-treatment, and the density of living snails decreased by 48.10%, 63.29%, 67.09% and 69.62% 14 days post-treatment relative to pre-treatment, respectively.Conclusions: Chemical treatment with drones is feasible for O. hupensis snail control in marshland areas; however, the molluscicidal effect of spraying 5% niclosamide ethanolamine salt granules with drones is comparable to spraying chemicals manually in marshland areas regardless of environmental cleaning.","PeriodicalId":38874,"journal":{"name":"中国血吸虫病防治杂志","volume":"36 5","pages":"531-534"},"PeriodicalIF":0.0,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Population genetic diversity of Culex tritaeniorhynchus in Jining City of Shandong Province based on the mitochondrial cytochrome C oxidase I gene]. [基于线粒体细胞色素C氧化酶I基因的山东省济宁市三带喙库蚊种群遗传多样性研究]。

Q3 Medicine

中国血吸虫病防治杂志

Pub Date : 2024-10-24 DOI: 10.16250/j.32.1915.2024119

Y Zhang, C Zang, X Pan, M Gong, H Liu

Objective: To understand the genetic basis of the adaptation of Culex tritaeniorhynchus to different environmental ecology in Jining City, Shandong Province, so as to provide insights into understanding of the population structure or isolation pattern of Cx. tritaeniorhynchus in the city.Methods: Seven sampling sites were selected from urban, suburban and rural areas of Jining City, Shandong Province from June to August 2023, and mosquitoes were collected using mosquito-trapping lamps. All collected adult mosquitoes were identified morphologically. Genomic DNA was extracted from a single female Cx. tritaeniorhynchus mosquito, and the mitochondrial cytochrome C oxidase I (COI) gene was amplified using a PCR assay, sequenced and subjected to molecular identification. The number of haplotypes, haplotype diversity (Hd), nucleotide diversity (Pi), and average number of nucleotide differences (K) of Cx. tritaeniorhynchus DNA sequences were estimated among different sampling sites using the software DnaSP 6, and a neutrality test was performed. The fixation index (FST), and gene flow (number of migrants, Nm) of Cx. tritaeniorhynchus populations were calculated using the software Arlequin 3.5.2, and subjected to analysis of molecular variance (AMOVA). In addition, a haplotype network diagrams and a phylogenetic tree of Cx. tritaeniorhynchus populations were created using the software PopART and MEGA 11, respectively.Results: A total of 420 sequences were successfully amplified from the COI gene of Cx. tritaeniorhynchus samples collected from 7 sampling sites in Jining City, and a gene fragment sequence with a length of 603 bp was obtained, with 55 variable sites and 46 haplotypes and without insertion or deletion mutations. Of the 46 haplotypes, H01 was the dominant shared haplotype, and the haplotype frequency increased gradually from urban areas (34.00%) to rural areas (47.00%). The mean Hd, Pi and K values of Cx. tritaeniorhynchus COI genes were 0.814, 0.024 and 14.129, 0.489, 0.016 and 7.941 and 0.641, 0.016 and 10.393 in suburban, urban, and rural areas, respectively, with the highest population diversity of Cx. tritaeniorhynchus in suburban areas and the lowest in urban areas. Paired FST analysis among different types of sampling sites showed that the mean FST value was 0.029 between urban and suburban areas, indicating more frequent inter-population communication. AMOVA revealed that the percentage of intra-population variation (95.74%) was higher than that of inter-population variation (4.26%). Neutrality tests showed deviation from neutrality in Cx. tritaeniorhynchus populations collected from Nanyang Township (Tajima's D = 2.793, Fu's Fs = 6.429, both P values < 0.05). In a

目的：了解山东省济宁市三带喙库蚊对不同环境生态适应的遗传基础，为了解三带喙库蚊种群结构或分离格局提供依据。三带喙龙在城市。方法：于2023年6 - 8月在山东省济宁市市区、郊区和农村选取7个采样点，采用诱蚊灯采集蚊虫。收集到的所有成蚊均进行形态鉴定。从单个雌性Cx中提取基因组DNA。三带喙蚊线粒体细胞色素C氧化酶I （cytochrome C oxidase I， COI）基因通过PCR扩增，测序并进行分子鉴定。Cx的单倍型数量、单倍型多样性（Hd）、核苷酸多样性（Pi）和平均核苷酸差异数(K)。利用dnasp6软件估算不同采样点三带喙龙DNA序列，并进行中立性检验。Cx的固定指数（FST）和基因流（迁移数，Nm）。采用Arlequin 3.5.2软件计算三带喙库蚊种群，并进行分子方差分析（AMOVA）。此外，还绘制了Cx的单倍型网络图和系统发育树。利用PopART和mega11软件分别建立三带喙库种群。结果：从Cx的COI基因中成功扩增出420个序列。从济宁市7个采样点采集三带喙库蚊样本，获得长度为603 bp的基因片段序列，包含55个可变位点，46个单倍型，无插入或缺失突变。在46个单倍型中，H01为优势共享单倍型，单倍型频率由城市（34.00%）向农村（47.00%）逐渐增加。Cx的Hd， Pi和K值的平均值。三带喙库蚊COI基因在郊区、城市和农村分别为0.814、0.024和14.129、0.489、0.016和7.941、0.641、0.016和10.393，种群多样性最高。郊区以三带喙蚊居多，城区以三带喙蚊居少。不同类型采样点间的FST配对分析表明，城市与郊区的平均FST值为0.029，表明人口间交流更为频繁。AMOVA分析结果显示，种群内变异比例（95.74%）高于种群间变异比例（4.26%）。中性试验显示Cx偏离中性。南洋乡三带喙蚊种群（Tajima’s D = 2.793, Fu’s Fs = 6.429， P值均< 0.05）。此外，Cx的失配分布曲线。济宁市三带喙库蚊COI基因呈双峰或多峰分布，总体种群规模相对稳定。结论：线粒体COI基因可作为Cx种群遗传多样性研究的分子标记。tritaeniorhynchus。Cx的群体遗传多样性。济宁市郊区三带喙库蚊种群数量高于农村和城市，且三带喙库蚊种群间基因交流频繁。城市和郊区三带喙蚊种群。

{"title":"[Population genetic diversity of Culex tritaeniorhynchus in Jining City of Shandong Province based on the mitochondrial cytochrome C oxidase I gene].","authors":"Y Zhang, C Zang, X Pan, M Gong, H Liu","doi":"10.16250/j.32.1915.2024119","DOIUrl":"https://doi.org/10.16250/j.32.1915.2024119","url":null,"abstract":"Objective: To understand the genetic basis of the adaptation of Culex tritaeniorhynchus to different environmental ecology in Jining City, Shandong Province, so as to provide insights into understanding of the population structure or isolation pattern of Cx. tritaeniorhynchus in the city.Methods: Seven sampling sites were selected from urban, suburban and rural areas of Jining City, Shandong Province from June to August 2023, and mosquitoes were collected using mosquito-trapping lamps. All collected adult mosquitoes were identified morphologically. Genomic DNA was extracted from a single female Cx. tritaeniorhynchus mosquito, and the mitochondrial cytochrome C oxidase I (COI) gene was amplified using a PCR assay, sequenced and subjected to molecular identification. The number of haplotypes, haplotype diversity (Hd), nucleotide diversity (Pi), and average number of nucleotide differences (K) of Cx. tritaeniorhynchus DNA sequences were estimated among different sampling sites using the software DnaSP 6, and a neutrality test was performed. The fixation index (FST), and gene flow (number of migrants, Nm) of Cx. tritaeniorhynchus populations were calculated using the software Arlequin 3.5.2, and subjected to analysis of molecular variance (AMOVA). In addition, a haplotype network diagrams and a phylogenetic tree of Cx. tritaeniorhynchus populations were created using the software PopART and MEGA 11, respectively.Results: A total of 420 sequences were successfully amplified from the COI gene of Cx. tritaeniorhynchus samples collected from 7 sampling sites in Jining City, and a gene fragment sequence with a length of 603 bp was obtained, with 55 variable sites and 46 haplotypes and without insertion or deletion mutations. Of the 46 haplotypes, H01 was the dominant shared haplotype, and the haplotype frequency increased gradually from urban areas (34.00%) to rural areas (47.00%). The mean Hd, Pi and K values of Cx. tritaeniorhynchus COI genes were 0.814, 0.024 and 14.129, 0.489, 0.016 and 7.941 and 0.641, 0.016 and 10.393 in suburban, urban, and rural areas, respectively, with the highest population diversity of Cx. tritaeniorhynchus in suburban areas and the lowest in urban areas. Paired FST analysis among different types of sampling sites showed that the mean FST value was 0.029 between urban and suburban areas, indicating more frequent inter-population communication. AMOVA revealed that the percentage of intra-population variation (95.74%) was higher than that of inter-population variation (4.26%). Neutrality tests showed deviation from neutrality in Cx. tritaeniorhynchus populations collected from Nanyang Township (Tajima's D = 2.793, Fu's Fs = 6.429, both P values < 0.05). In a","PeriodicalId":38874,"journal":{"name":"中国血吸虫病防治杂志","volume":"36 5","pages":"466-473"},"PeriodicalIF":0.0,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Cost-effectiveness analysis of chemical treatment with drones for Oncomelania hupensis control in marshland and lake areas]. [无人机化学防治沼泽湖区钉螺的成本-效果分析]。

Q3 Medicine

中国血吸虫病防治杂志

Pub Date : 2024-10-24 DOI: 10.16250/j.32.1915.2024128

Y Chen, X Xu, D Wen, B Dai, L Gao, R Zhang, Q Huang, L Li, F Zha, L Fang, P Zhang, S Zhang, C Cao

Objective: To evaluate the molluscicidal effect and cost of spraying molluscicides with drones against Oncomelania hupensis snails in marshland and lake areas, so as to provide new insights into field snail control in China.Methods: A marshland and lake setting measuring approximately 12 000 m2 was selected in Wanzhi District, Wuhu City on June 2023 as the test field, and assigned to four groups, of 3 000 m2 in each group. Environmental cleaning was not conducted in groups A or B, which were given 5% niclosamide ethanolamine salt granules sprayed with knapsack-type sprayers and drones at a dose of 40 g/m2, and environmental cleaning was conducted in groups C and D, which were given 5% niclosamide ethanolamine salt granules sprayed with drones and knapsack-type sprayers at a dose of 40 g/m2, respectively. O. hupensis snails were surveyed before chemical treatment and 1, 3, 5, 7, 14 days post-treatment. The uniformity of chemicals was determined on the day of treatment, and the snail mortality, corrected snail mortality and density of living snails were calculated and compared among groups. The cost of molluscicides, labor fees of environmental cleaning and chemical treatment and cost of equipment were calculated, and the cost for a 1% reduction in the mean density of living snails was calculated 14 days post-treatment.Results: The mean densities of living snails and mortality rates of snails were 1.82 to 2.85 snails/0.1 m2 and 1.41% to 2.94% in groups A, B, C and D before chemical treatment, and the mortality and corrected mortality of snails were 55.75%, 49.32%, 85.94% and 87.50%, and 55.00%, 48.47%, 85.70% and 87.29% in groups A, B, C and D 14 days post-treatment. There was a significant difference in the mortality of snails among the four groups 14 days post-treatment (χ2 = 38.735, P < 0.005), and there was a higher snail mortality in Group D than in Group A (χ2 = 16.876, P < 0.005), and higher in Group C than in Group B (χ2 = 20.508, P < 0.005). The density of living snails reduced by 55.00%, 43.94%, 90.43% and 87.14% 14 days post-treatment relative to pre-treatment in groups A, B, C and D, respectively. The test for uniformity of chemicals showed that the mean dose of molluscicides were 57.34, 55.21, 40.19 g/m2 and 32.37 g/m2 in groups A, B, C and D, respectively, and the minimal standard deviation (7.07) and coefficient of variation (0.18) of mean doses were seen in Group C. The costs for chemical treatment were 0.33 Yuan in groups A and B and 1.53 Yuan in groups C and D, respectively. The costs for a 1% reduction in the mean density of living snails were 17.82, 22.47, 50.73 Yuan and 52.56 Yuan in groups A, B, C, and D 14 days post-treatment, respectively.Conclusions: The molluscicidal effect and cost of spra

目的：评价无人机对沼泽湖区钉螺的杀螺效果和成本，为中国野外钉螺防治提供新的思路。方法：于2023年6月在芜湖市万治区选取约1.2万m2的湿地和湖泊作为试验田，分为4组，每组3 000 m2。A组和B组不进行环境清洁，分别给予5%硝氯胺乙醇胺盐颗粒，使用背包式喷雾器和无人机喷洒，剂量为40 g/m2； C组和D组分别给予5%硝氯胺乙醇胺盐颗粒，使用无人机和背包式喷雾器喷洒，剂量为40 g/m2。分别于化学处理前和处理后1、3、5、7、14 d对钉螺进行调查。测定处理当日药剂均匀性，计算各组钉螺死亡率、校正钉螺死亡率和活螺密度并进行比较。计算杀螺剂成本、环境清洗和化学处理人工费用及设备费用，计算处理后14 d平均活螺密度降低1%的成本。结果：化学处理前A、B、C、D组钉螺平均活密度为1.82 ~ 2.85只/0.1 m2，钉螺死亡率为1.41% ~ 2.94%，处理后14 D A、B、C、D组钉螺死亡率和校正死亡率分别为55.75%、49.32%、85.94%和87.50%，处理后14 D A、B、C、D组钉螺死亡率分别为55.00%、48.47%、85.70%和87.29%。治疗14 D后4组钉螺死亡率差异有统计学意义（χ2 = 38.735, P < 0.005），其中D组钉螺死亡率高于a组（χ2 = 16.876, P < 0.005）， C组钉螺死亡率高于B组（χ2 = 20.508, P < 0.005）。处理14 D后，A、B、C、D组钉螺活密度分别较处理前降低55.00%、43.94%、90.43%、87.14%。化学药剂均一性检验结果显示，A、B、C、D组杀螺剂平均剂量分别为57.34、55.21、40.19、32.37 g/m2， C组平均剂量标准差最小（7.07），变异系数最小（0.18），化学药剂处理费用A、B组分别为0.33元、C、D组分别为1.53元。a、B、C、D组平均钉螺密度每降低1%，处理后14 D的成本分别为17.82元、22.47元、50.73元、52.56元。结论：无人机喷洒5%氯硝沙胺乙醇胺盐颗粒的杀螺效果和成本与人工喷洒相当，且无人机化学处理杀螺剂均一性高，省时省力，适用于复杂环境，值得在防螺领域广泛应用。

{"title":"[Cost-effectiveness analysis of chemical treatment with drones for Oncomelania hupensis control in marshland and lake areas].","authors":"Y Chen, X Xu, D Wen, B Dai, L Gao, R Zhang, Q Huang, L Li, F Zha, L Fang, P Zhang, S Zhang, C Cao","doi":"10.16250/j.32.1915.2024128","DOIUrl":"https://doi.org/10.16250/j.32.1915.2024128","url":null,"abstract":"Objective: To evaluate the molluscicidal effect and cost of spraying molluscicides with drones against Oncomelania hupensis snails in marshland and lake areas, so as to provide new insights into field snail control in China.Methods: A marshland and lake setting measuring approximately 12 000 m2 was selected in Wanzhi District, Wuhu City on June 2023 as the test field, and assigned to four groups, of 3 000 m2 in each group. Environmental cleaning was not conducted in groups A or B, which were given 5% niclosamide ethanolamine salt granules sprayed with knapsack-type sprayers and drones at a dose of 40 g/m2, and environmental cleaning was conducted in groups C and D, which were given 5% niclosamide ethanolamine salt granules sprayed with drones and knapsack-type sprayers at a dose of 40 g/m2, respectively. O. hupensis snails were surveyed before chemical treatment and 1, 3, 5, 7, 14 days post-treatment. The uniformity of chemicals was determined on the day of treatment, and the snail mortality, corrected snail mortality and density of living snails were calculated and compared among groups. The cost of molluscicides, labor fees of environmental cleaning and chemical treatment and cost of equipment were calculated, and the cost for a 1% reduction in the mean density of living snails was calculated 14 days post-treatment.Results: The mean densities of living snails and mortality rates of snails were 1.82 to 2.85 snails/0.1 m2 and 1.41% to 2.94% in groups A, B, C and D before chemical treatment, and the mortality and corrected mortality of snails were 55.75%, 49.32%, 85.94% and 87.50%, and 55.00%, 48.47%, 85.70% and 87.29% in groups A, B, C and D 14 days post-treatment. There was a significant difference in the mortality of snails among the four groups 14 days post-treatment (χ2 = 38.735, P < 0.005), and there was a higher snail mortality in Group D than in Group A (χ2 = 16.876, P < 0.005), and higher in Group C than in Group B (χ2 = 20.508, P < 0.005). The density of living snails reduced by 55.00%, 43.94%, 90.43% and 87.14% 14 days post-treatment relative to pre-treatment in groups A, B, C and D, respectively. The test for uniformity of chemicals showed that the mean dose of molluscicides were 57.34, 55.21, 40.19 g/m2 and 32.37 g/m2 in groups A, B, C and D, respectively, and the minimal standard deviation (7.07) and coefficient of variation (0.18) of mean doses were seen in Group C. The costs for chemical treatment were 0.33 Yuan in groups A and B and 1.53 Yuan in groups C and D, respectively. The costs for a 1% reduction in the mean density of living snails were 17.82, 22.47, 50.73 Yuan and 52.56 Yuan in groups A, B, C, and D 14 days post-treatment, respectively.Conclusions: The molluscicidal effect and cost of spra","PeriodicalId":38874,"journal":{"name":"中国血吸虫病防治杂志","volume":"36 5","pages":"502-506"},"PeriodicalIF":0.0,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Epidemiological and spatial distribution characteristics of Clonorchis sinensis human infections in Guangdong Province from 2016 to 2022]. 2016 - 2022年广东省人感染华支睾吸虫流行病学及空间分布特征

Q3 Medicine

中国血吸虫病防治杂志

Pub Date : 2024-10-23 DOI: 10.16250/j.32.1374.2024097

G Zhang, Q Zhang, Y Fang, F Pei, Q Mao, J Liu, Z Deng, D Wu, W Lu, J Liu, Y Liao, J Zhang, J Chen

Objective: To investigate the epidemiological characteristics and spatial distribution characteristics of Clonorchis sinensis human infections in Guangdong Province from 2016 to 2022, so as to provide insights into formulation of the clonorchiasis control measures in the province.Methods: Xinhui District of Jiangmen City, Longmen County of Huizhou City and Wengyuan County of Shaoguan City in Guangdong Province were selected as fixed surveillance sites for human clonorchiasis from 2016 to 2022, and additional 10% to 15% counties (districts) endemic for clonorchiasis were sampled from Guangdong Province as mobile surveillance sites each year from 2016 to 2022. A village (community) was randomly selected from each surveillance site according to the geographical orientations of east, west, south, north and middle, and subjects were randomly sampled from each village (community). C. sinensis eggs were detected in subjects' stool samples using the Kato-Katz technique, and the prevalence and intensity of C. sinensis infections were calculated. In addition, subjects' gender, age, ethnicity, educational level and occupation were collected. The Guangdong Provincial 1:1 million electronic map in vector format was downloaded from the National Geomatics Center of China, and kernel density analysis and spatial autocorrelation analysis of C. sinensis human infections in Guangdong Province from 2016 to 2022 were performed using the software ArcGIS 10.7.Results: A total of 153 188 residents were tested for C. sinensis infections in Guangdong Province from 2016 to 2022, including 75 596 men (49.35%) and 77 592 women (50.65%), and there were 5 369 residents infected with C. sinensis, with 3.50% overall prevalence of infections. The prevalence rates of severe, moderate and mild C. sinensis infections were 0.76%, 7.26% and 91.97% among C. sinensis-infected residents in Guangdong Province from 2016 to 2022, and there were age-, gender-, ethnicity-, occupation- and educational level-specific prevalence of C. sinensis human infections (χ2 = 2 578.31, 637.33, 52.22, 2 893.28 and 1 139.33, all P values < 0.05). Global spatial autocorrelation analysis showed a cluster in the prevalence of C. sinensis human infections in Guangdong Province (Moran's I = 0.63, Z = 27.31, P < 0.05). Kernel density analysis showed that the prevalence of C. sinensis human infections with a high kernel density in Guangdong Province was mainly distributed along the Zhujiang River basin in Pearl River Delta areas, followed by in eastern and northern Guangdong Province. In addition, local spatial autocorrelation analysis identified 73 high-high clusters of the prevalence of C. sinensis human infections in Guangdong Province.Conclusions: The prevalence of C. sinensis human infection

目的：了解2016 - 2022年广东省华支睾吸虫病人感染的流行病学特征和空间分布特征，为广东省华支睾吸虫病防控措施的制定提供依据。方法：选择广东省江门市新会区、惠州市龙门县和韶关市翁源县为2016 - 2022年人支睾吸虫病固定监测点，2016 - 2022年每年在广东省另外抽取10% ~ 15%的支睾吸虫病流行县（区）作为流动监测点。每个监测点按东、西、南、北、中地理方位随机抽取1个村（社区），每个村（社区）随机抽取受试者。采用加藤-卡茨法检测粪便标本中中华按蚊虫卵，计算中华按蚊感染流行率和感染强度。此外，还收集了受试者的性别、年龄、种族、教育程度和职业。从中国国家地理信息中心下载广东省1:1万矢量电子地图，利用ArcGIS 10.7软件对2016 - 2022年广东省中华按蚊人感染情况进行核密度分析和空间自相关分析。结果：2016 - 2022年，广东省共检测居民中华按蚊感染153 188人，其中男性75 596人（49.35%），女性77 592人（50.65%），共有5 369人感染中华按蚊，总感染率为3.50%。2016 - 2022年广东省居民中华按蚊重度、中度和轻度感染检出率分别为0.76%、7.26%和91.97%，存在年龄、性别、种族、职业、学历差异（χ2 = 2 578.31、637.33、52.22、2 893.28、1 139.33，P值均< 0.05）。全球空间自相关分析显示，广东省中华按蚊人感染呈聚类分布（Moran’s I = 0.63, Z = 27.31, P < 0.05）。核密度分析结果显示，广东省中华按蚊人感染核密度较高的流行区主要分布在珠江三角洲一带，其次是粤东和粤北地区。此外，通过局部空间自相关分析，确定了广东省中华按蚊人感染流行的73个高、高聚集型。结论：2016 - 2022年广东省华支睾吸虫病人感染高发，病例以轻度感染为主，华支睾吸虫病人感染呈空间聚集性分布。需要在高危人群和地区采取针对性的支睾吸虫病控制措施。

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引用次数: 0

[Trends in areas of Oncomelania hupensis snail habitats in Anhui Province from 2004 to 2023 based on the Mann-Kendall test]. [基于Mann-Kendall检验的2004 - 2023年安徽省钉螺生境变化趋势]。

Q3 Medicine

中国血吸虫病防治杂志

Pub Date : 2024-10-22 DOI: 10.16250/j.32.1915.2024053

F Gao, S Zhang, S Ding, X Xu, T Wang, B Dai

Objective: To investigate the trends in areas of Oncomelania hupensis snail habitats in Anhui Province from 2004 to 2023, so as to provide insights into facilitating the progress of schistosomiasis elimination in the province.

Methods: Areas of O. hupensis snail habitats in Anhui Province from 2004 to 2023 were collected, and the trends in and mutations of O. hupensis snail habitats in Anhui Province, and the trends in O. hupensis snail habitats in different types of schistosomiasis-endemic foci and in different cities of Anhui Province from 2004 to 2023 were analyzed using Mann-Kendall test.

Results: The areas of O. hupensis snail habitats reduced by 12.62% in Anhui Province in 2023 relative to in 2004. Mann-Kendall trend test showed that the areas of O. hupensis snail habitats appeared a tendency towards a decline in Anhui Province from 2004 to 2023 (Z = -3.926, P < 0.001, β = -215.66), with an annual average reduction of 215.66 hm². Mann-Kendall mutation test showed that the areas of O. hupensis snail habitats appeared a tendency towards a decline in Anhui Province since 2015 (|Z| > U_0.05, P < 0.05). The areas of O. hupensis snail habitats appeared a tendency towards a decline in marshland and lake regions (Z = -4.899, P < 0.001, β = -260.13), and a tendency towards a rise in hilly regions of Anhui Province from 2004 to 2023 (Z = 2.758, P < 0.01, β = 44.55). Among 9 cities endemic for schistosomiasis in Anhui Province, the areas of O. hupensis snail habitats appeared a tendency towards a decline in 5 cities of Ma'anshan, Tongling, Anqing, Huangshan and Chizhou (Z = -4.056 to -2.109, all P values < 0.05, β = -92.12 to -0.45). The average constituent ratios of areas of O. hupensis snail habitats were 88.19% and 11.81% in marshland and lake regions and hilly regions of Anhui Province from 2004 to 2023, respectively, and the ratio of areas of O. hupensis snail habitats in marshland and lake regions to areas of snail habitats in hilly regions reduced from 9.23∶1 in 2004 to 5.74∶1 in 2023 in Anhui Province, with the ratio appearing a tendency towards a decline (Z = -4.477, P < 0.001, β = -0.16).

Conclusions: The areas of O. hupensis snail habitats appeared a tendency towards a decline in Anhui Province from 2004 to 2023, with a reduction in areas of O. hupensis snail habitats in marshland and lake regions and a rise in hilly regions. Targeted O. hupensis snail control interventions are required tailored to real snail status.

目的：了解2004 - 2023年安徽省钉螺分布区钉螺分布趋势，为推进全省消灭血吸虫病工作提供参考。方法：收集2004 - 2023年安徽省血吸虫病流行区，采用Mann-Kendall检验分析2004 - 2023年安徽省不同类型血吸虫病流行疫源地和安徽省不同城市的血吸虫病流行区钉螺生境变化趋势和突变情况。结果：2023年安徽省钉螺栖息地面积较2004年减少12.62%；Mann-Kendall趋势检验表明，2004 - 2023年安徽省钉螺生境面积呈下降趋势（Z = -3.926, P < 0.001, β = -215.66），年平均减少215.66 hm2。Mann-Kendall突变检验结果显示，2015年以来安徽省钉螺栖息地面积呈下降趋势（|Z| > U0.05, P < 0.05）。2004 - 2023年安徽省湖沼区钉螺栖息地面积呈下降趋势（Z = -4.899, P < 0.001, β = -260.13），丘山区钉螺栖息地面积呈上升趋势（Z = 2.758, P < 0.01, β = 44.55）。在安徽省9个血吸虫病流行城市中，马鞍山、铜陵、安庆、黄山、池州5个城市的钉螺栖息地面积呈下降趋势（Z = -4.056 ~ -2.109， P值均< 0.05,β = -92.12 ~ -0.45）。地区的平均构成比o . hupensis蜗牛栖息地的分别为88.19%和11.81%在沼泽地和湖地区和丘陵地区的安徽省从2004年到2023年,分别和o . hupensis领域比蜗牛栖息地在沼泽地和湖地区丘陵地区的蜗牛栖息地减少的地区从2004年的9.23∶1 5.74∶1 2023年安徽省率出现下降的倾向(Z = -4.477, P < 0.001,β= -0.16)。结论：2004 - 2023年安徽省湖北钉螺生境面积呈下降趋势，沼泽和湖泊地区钉螺生境面积减少，丘陵地区钉螺生境面积增加。有针对性的控制钉螺干预措施需要根据实际钉螺状况量身定制。

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引用次数: 0