Pub Date : 2020-10-23DOI: 10.2174/1874303x02013010032
R. C. Cavalli, Mateus Cosentino Bellote, Maurício Carvalho
Extracorporeal Shock Wave Lithotripsy (SWL) remains one of the most popular methods for treating urinary lithiasis. To evaluate structural and microtomographic characteristics associated with urinary calculi fragmentation in an experimental model of SWL. Samples consisting of at least two calculi fragments obtained from patients were submitted to urological procedures. All calculi were analyzed by X-ray diffraction and a morphological evaluation (weight, length, width, and volume measurements) was conducted along with microtomographic and conventional tomographic assessments in vitro. Thereafter, each sample was submitted to SWL in a ballistic gelatin model. The fragments were separated, using a granulometric sieve, into specimens larger than 4 mm and 2 mm, which were subsequently weighed. Altogether, 48 urinary calculi were analyzed and were composed of whewellite (54%), struvite (22%), apatite (11%), uric acid (7%), cystine (4%), and whitlockite (2%). The fragmentation rate was 77.5% and 69.6% for samples > 4 mm and > 2 mm in size, respectively. Factors associated with a reduction in the effectiveness of SWL were volume, dry mass, and width of the calculus. The radiodensity and porosity of the samples evaluated by microtomography were not associated with the fragmentation of calculi. The volume, dry mass, and width of urinary calculi were positively correlated with the number of fragments larger than 4 and 2 mm in size obtained post-SWL.
{"title":"Porosity in Microtomography and Determination of Hounsfield Units do not Predict Calculi Fragmentation in Extracorporeal Lithotripsy: Analysis of an In-vitro Study","authors":"R. C. Cavalli, Mateus Cosentino Bellote, Maurício Carvalho","doi":"10.2174/1874303x02013010032","DOIUrl":"https://doi.org/10.2174/1874303x02013010032","url":null,"abstract":"\u0000 \u0000 Extracorporeal Shock Wave Lithotripsy (SWL) remains one of the most popular methods for treating urinary lithiasis.\u0000 \u0000 \u0000 \u0000 To evaluate structural and microtomographic characteristics associated with urinary calculi fragmentation in an experimental model of SWL.\u0000 \u0000 \u0000 \u0000 Samples consisting of at least two calculi fragments obtained from patients were submitted to urological procedures. All calculi were analyzed by X-ray diffraction and a morphological evaluation (weight, length, width, and volume measurements) was conducted along with microtomographic and conventional tomographic assessments in vitro. Thereafter, each sample was submitted to SWL in a ballistic gelatin model. The fragments were separated, using a granulometric sieve, into specimens larger than 4 mm and 2 mm, which were subsequently weighed.\u0000 \u0000 \u0000 \u0000 Altogether, 48 urinary calculi were analyzed and were composed of whewellite (54%), struvite (22%), apatite (11%), uric acid (7%), cystine (4%), and whitlockite (2%). The fragmentation rate was 77.5% and 69.6% for samples > 4 mm and > 2 mm in size, respectively. Factors associated with a reduction in the effectiveness of SWL were volume, dry mass, and width of the calculus. The radiodensity and porosity of the samples evaluated by microtomography were not associated with the fragmentation of calculi.\u0000 \u0000 \u0000 \u0000 The volume, dry mass, and width of urinary calculi were positively correlated with the number of fragments larger than 4 and 2 mm in size obtained post-SWL.\u0000","PeriodicalId":38952,"journal":{"name":"Open Urology and Nephrology Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49236755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-16DOI: 10.2174/1874303x02013010021
L. Dobrek, K. Nalik-Iwaniak, Z. Arent
The experiment was conducted on 3 groups: 1 – control, sham-treated rats, 2 – animals treated with 5 times the IF dose administered i.p. (50 mg/kg b.w.) and 3 – rats treated with 5 times the IF dose administered i.p. + NAC administered p.o. (200 mg/kg b.w.). The renal function was evaluated analysing classical and new protein parameters (cystatin C CysC, kidney injury molecule-1 – KIM-1 and nephrin NPH) in blood and urine. Furthermore, histopathological analysis of bladders and kidneys was carried out.
{"title":"The Effectiveness of N-acetylcysteine in Alleviating Kidney Dysfunction in Ifosfamide-treated Rats","authors":"L. Dobrek, K. Nalik-Iwaniak, Z. Arent","doi":"10.2174/1874303x02013010021","DOIUrl":"https://doi.org/10.2174/1874303x02013010021","url":null,"abstract":"The experiment was conducted on 3 groups: 1 – control, sham-treated rats, 2 – animals treated with 5 times the IF dose administered i.p. (50 mg/kg b.w.) and 3 – rats treated with 5 times the IF dose administered i.p. + NAC administered p.o. (200 mg/kg b.w.). The renal function was evaluated analysing classical and new protein parameters (cystatin C CysC, kidney injury molecule-1 – KIM-1 and nephrin NPH) in blood and urine. Furthermore, histopathological analysis of bladders and kidneys was carried out.","PeriodicalId":38952,"journal":{"name":"Open Urology and Nephrology Journal","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41923119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-31DOI: 10.2174/1874303x02013010018
A. H. Mohamed, A. Eraslan
Penetrating trauma of the abdominal Inferior Vena Cava remains a life-threatening injury. Nearly half of patients with an injury of abdominal Inferior Vena Cava die before reaching the hospital. This makes injuries of IVC often fetal and the management of these injuries is usually challenging. Early hospital transfer, prompt diagnosis, rapid bleeding control and diminishing shock period remain significantly important factors that improve the survival rate. We report a successful surgical management of suprarenal inferior vena cava injury case and associated organ injuries following a stab knife wound. Article History Received: January 15, 2020 Revised: May 13, 2020 Accepted: May 14, 2020
{"title":"A Successful Management of Supra-Renal Inferior Vena Cava Injury Following Penetrating Trauma: A Case Report","authors":"A. H. Mohamed, A. Eraslan","doi":"10.2174/1874303x02013010018","DOIUrl":"https://doi.org/10.2174/1874303x02013010018","url":null,"abstract":"Penetrating trauma of the abdominal Inferior Vena Cava remains a life-threatening injury. Nearly half of patients with an injury of abdominal Inferior Vena Cava die before reaching the hospital. This makes injuries of IVC often fetal and the management of these injuries is usually challenging. Early hospital transfer, prompt diagnosis, rapid bleeding control and diminishing shock period remain significantly important factors that improve the survival rate. We report a successful surgical management of suprarenal inferior vena cava injury case and associated organ injuries following a stab knife wound. Article History Received: January 15, 2020 Revised: May 13, 2020 Accepted: May 14, 2020","PeriodicalId":38952,"journal":{"name":"Open Urology and Nephrology Journal","volume":"13 1","pages":"18-20"},"PeriodicalIF":0.0,"publicationDate":"2020-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48049407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-23DOI: 10.2174/1874303x02013010013
F. Sharifiaghdas, Sepideh Sharifiaghdas, E. Maleki, B. Narouie, Abdolsamad Shikhzadeh, S. Mehrabi
Cryptorchidism or undescended testis is an evolutionary defect where one or both testes fail to descend into the scrotum. HCG causes the testes to fail, possibly due to weight gain, an increase in testicular vasculature, and stimulating the testosterone and di-hydro-testosterone. The present study has been conducted to evaluate the therapeutic effects of HCG on patients with unilateral cryptorchidism.
{"title":"Evaluation of Human Chorionic Gonadotropin (HCG) Therapeutic Results in Patients With Unilateral cryptorchidism (Undescended Testis)","authors":"F. Sharifiaghdas, Sepideh Sharifiaghdas, E. Maleki, B. Narouie, Abdolsamad Shikhzadeh, S. Mehrabi","doi":"10.2174/1874303x02013010013","DOIUrl":"https://doi.org/10.2174/1874303x02013010013","url":null,"abstract":"Cryptorchidism or undescended testis is an evolutionary defect where one or both testes fail to descend into the scrotum. HCG causes the testes to fail, possibly due to weight gain, an increase in testicular vasculature, and stimulating the testosterone and di-hydro-testosterone. The present study has been conducted to evaluate the therapeutic effects of HCG on patients with unilateral cryptorchidism.","PeriodicalId":38952,"journal":{"name":"Open Urology and Nephrology Journal","volume":"13 1","pages":"13-17"},"PeriodicalIF":0.0,"publicationDate":"2020-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48240348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-23DOI: 10.2174/1874303x02013010005
M. Tariq, S. Sulaiman
Potential studies were identified through a systematic search of recognized databases using keywords “prevalence,” “osteopenia,” “osteoporosis,” “Chronic Kidney Disease,” “CKD patients,” “Chronic Renal Failure,” “CRF patients,” “Bone Mineral Density,” and “low bone mass” to identify relevant articles. An article was included in the review if the study met the following criteria: 1) conducted in CKD patients aged 18 years and above, 2) Osteopenia and osteoporosis were determined through Bone Mineral Density (BMD) testing, and 3) T scores were determined for all patients. The studies including transplant patients were not included in this review.
通过使用关键词“患病率”、“骨质减少”、“骨质疏松”、“慢性肾脏疾病”、“CKD患者”、“慢性肾衰竭”、“CRF患者”、“骨矿物质密度”和“低骨量”对公认数据库进行系统搜索，确定潜在的研究，以确定相关文章。如果研究符合以下标准，则纳入一篇文章:1)在18岁及以上的CKD患者中进行，2)通过骨密度(Bone Mineral Density, BMD)检测骨质减少和骨质疏松症，3)确定所有患者的T评分。包括移植患者的研究未包括在本综述中。
{"title":"Prevalence of Osteopenia and Osteoporosis among Chronic Kidney Disease Patients: A Systematic Review","authors":"M. Tariq, S. Sulaiman","doi":"10.2174/1874303x02013010005","DOIUrl":"https://doi.org/10.2174/1874303x02013010005","url":null,"abstract":"Potential studies were identified through a systematic search of recognized databases using keywords “prevalence,” “osteopenia,” “osteoporosis,” “Chronic Kidney Disease,” “CKD patients,” “Chronic Renal Failure,” “CRF patients,” “Bone Mineral Density,” and “low bone mass” to identify relevant articles. An article was included in the review if the study met the following criteria: 1) conducted in CKD patients aged 18 years and above, 2) Osteopenia and osteoporosis were determined through Bone Mineral Density (BMD) testing, and 3) T scores were determined for all patients. The studies including transplant patients were not included in this review.","PeriodicalId":38952,"journal":{"name":"Open Urology and Nephrology Journal","volume":"13 1","pages":"5-12"},"PeriodicalIF":0.0,"publicationDate":"2020-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42985805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-12DOI: 10.2174/1874303x02013010001
H. Kasim, S. Zatalia, H. Rasyid, S. Bakri, M. L. Parewangi, F. Akil, A. Seweng
Cross-sectional study was conducted on patients who held Abdominal USG in Wahidin Sudirohusodo & UNHAS hospital from January to December 2017. NAFLD subjects are male and female (18-60 years) who met NAFLD criteria and wanted to participate, non-NAFLD as control subjects. NAFLD is fat accumulation in hepatocyte without a history of alcohol consumption or other etiology of chronic liver disease. CKD definition and classification were based on KDIGO 2012. P value <0.05 was considered to be significant.
{"title":"Correlation Between Non-Alcoholic Fatty Liver and Chronic Kidney Disease","authors":"H. Kasim, S. Zatalia, H. Rasyid, S. Bakri, M. L. Parewangi, F. Akil, A. Seweng","doi":"10.2174/1874303x02013010001","DOIUrl":"https://doi.org/10.2174/1874303x02013010001","url":null,"abstract":"Cross-sectional study was conducted on patients who held Abdominal USG in Wahidin Sudirohusodo & UNHAS hospital from January to December 2017. NAFLD subjects are male and female (18-60 years) who met NAFLD criteria and wanted to participate, non-NAFLD as control subjects. NAFLD is fat accumulation in hepatocyte without a history of alcohol consumption or other etiology of chronic liver disease. CKD definition and classification were based on KDIGO 2012. P value <0.05 was considered to be significant.","PeriodicalId":38952,"journal":{"name":"Open Urology and Nephrology Journal","volume":"13 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2020-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47516724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-31DOI: 10.2174/1874303x01912010077
E. Kwiatkowska, Martyna Opara, S. Kwiatkowski, L. Domański, M. Marchelek-Myśliwiec, K. Ciechanowski
Background: According to the currently applicable KDIGO-2012 and ERBP 2013 guidelines, iron metabolism assessments for patients with Chronic Kidney Disease (CKD) are performed using such parameters as ferritin concentration and Transferrin Saturation (TSAT). Their values are to be treated as a basis on which to decide on providing iron substitution. Patients with Stage 5 CKD on maintenance hemodialysis commonly suffer from malnutrition syndrome and inflammation. One of the markers for malnutrition and inflammation is low transferrin concentration. Our study focused on establishing what percentage of patients this applied to and whether or not the transferrin saturation figure was artificially inflated in such cases. Materials and Methods: The study group included 66 patients with Stage 5 CKD on maintenance hemodialysis. Such data were analyzed as complete blood count, iron and ferritin concentrations, and Transferrin Saturation (TSAT). Other parameters age, sex, time from their first hemodialysis, and the quality of their dialysis in the last six months – the Kt/V average.
{"title":"Is Transferrin Saturation a Useful Marker of Iron Metabolism in Patients with Chronic Kidney Disease Treated with Hemodialysis?","authors":"E. Kwiatkowska, Martyna Opara, S. Kwiatkowski, L. Domański, M. Marchelek-Myśliwiec, K. Ciechanowski","doi":"10.2174/1874303x01912010077","DOIUrl":"https://doi.org/10.2174/1874303x01912010077","url":null,"abstract":"Background: According to the currently applicable KDIGO-2012 and ERBP 2013 guidelines, iron metabolism assessments for patients with Chronic Kidney Disease (CKD) are performed using such parameters as ferritin concentration and Transferrin Saturation (TSAT). Their values are to be treated as a basis on which to decide on providing iron substitution. Patients with Stage 5 CKD on maintenance hemodialysis commonly suffer from malnutrition syndrome and inflammation. One of the markers for malnutrition and inflammation is low transferrin concentration. Our study focused on establishing what percentage of patients this applied to and whether or not the transferrin saturation figure was artificially inflated in such cases. Materials and Methods: The study group included 66 patients with Stage 5 CKD on maintenance hemodialysis. Such data were analyzed as complete blood count, iron and ferritin concentrations, and Transferrin Saturation (TSAT). Other parameters age, sex, time from their first hemodialysis, and the quality of their dialysis in the last six months – the Kt/V average.","PeriodicalId":38952,"journal":{"name":"Open Urology and Nephrology Journal","volume":"12 1","pages":"77-82"},"PeriodicalIF":0.0,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43589695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-15DOI: 10.2174/1874303x01912010072
K. Sampathkumar, R. Saravanan
Both groups were treated with Intravenous saline therapy before contrast exposure. The primary end point was contrast-Induced AKI. Baseline characteristics were comparable in both groups. Mean GFR in ml/min was similar in both groups (RIPC 54.8+/9 ml/min; Control 54.8+/9 ml/min) . Contrast-induced AKI occurred in 19/50 patients in control group and 6/50 in IPC group (p = 0.005).Hemodialysis was required only in control group (4/50) (p = 0.058). 30 day rehospitalization was more in control group (8 / 50) than RIPC group (1/50) (p = 0.01). RIPC was welltolerated without adverse effects.
{"title":"A Randomized Controlled Study of Remote Ischemic Preconditioning for Prevention of Contrast-Induced Nephropathy","authors":"K. Sampathkumar, R. Saravanan","doi":"10.2174/1874303x01912010072","DOIUrl":"https://doi.org/10.2174/1874303x01912010072","url":null,"abstract":"Both groups were treated with Intravenous saline therapy before contrast exposure. The primary end point was contrast-Induced AKI. Baseline characteristics were comparable in both groups. Mean GFR in ml/min was similar in both groups (RIPC 54.8+/9 ml/min; Control 54.8+/9 ml/min) . Contrast-induced AKI occurred in 19/50 patients in control group and 6/50 in IPC group (p = 0.005).Hemodialysis was required only in control group (4/50) (p = 0.058). 30 day rehospitalization was more in control group (8 / 50) than RIPC group (1/50) (p = 0.01). RIPC was welltolerated without adverse effects.","PeriodicalId":38952,"journal":{"name":"Open Urology and Nephrology Journal","volume":"104 ","pages":"72-76"},"PeriodicalIF":0.0,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41271831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-30DOI: 10.2174/1874303x01912010066
E. Nugroho, Arifin Hidayat, A. T. Hidayat
Kidney transplantation has been known as a major advancement of modern medicine which provides high-quality life years to patients with irreversible kidney failure (end-stage renal disease, ESRD) worldwide. The first kidney transplantation in Semarang was carried out at Telogorejo Hospital in 1985. Dr. Kariadi Hospital, has also undertaken kidney transplantation 28 times since January 2014 until September 2018. Kidney ischemic time is one of the most important factors which can affect the outcome of kidney transplantation. Prolonged ischemia of the graft can be related to transplantation’s effects. This study aimed to evaluate the influence of warm and cold ischemic time on the outcome of kidney transplantation in Dr. Kariadi Hospital Semarang. This is an observational, cross-sectional study. The data was collected from medical record of all patients who underwent kidney transplantation from January 2014 until December 2018 and the level of creatinine and urine production before and after transplantation was documented. A total of 28 patients were registered and completed the inclusion criteria. The results of the study were tabulated and statistical analysis was performed using SPSS 23.0. The relationship was declared meaningful if p = 0.05 was obtained. From the analysis of the research that has been done using the Pearson correlation test and hypothesis test Wilcoxon, it was found that there was a relationship between ischemic time and a decrease in creatinine level from r = -0.4489 with a value of p = 0.008. From the analysis of the research, a relationship between ischemic time and urine production was found after transplantation with a value of r = -0.562 and a value of p = 0.002. The results of this study show a strong correlation between the length of total ischemic time with a decrease in creatinine and urine production which means that the longer ischemic time, the lower the decrease in creatinine levels and the lesser the urine production.
{"title":"Correlation of Warm and Cold Ischemic Time to Graft Function in Kidney Transplant: A Single Centre Report","authors":"E. Nugroho, Arifin Hidayat, A. T. Hidayat","doi":"10.2174/1874303x01912010066","DOIUrl":"https://doi.org/10.2174/1874303x01912010066","url":null,"abstract":"\u0000 \u0000 Kidney transplantation has been known as a major advancement of modern medicine which provides high-quality life years to patients with irreversible kidney failure (end-stage renal disease, ESRD) worldwide. The first kidney transplantation in Semarang was carried out at Telogorejo Hospital in 1985. Dr. Kariadi Hospital, has also undertaken kidney transplantation 28 times since January 2014 until September 2018. Kidney ischemic time is one of the most important factors which can affect the outcome of kidney transplantation. Prolonged ischemia of the graft can be related to transplantation’s effects. This study aimed to evaluate the influence of warm and cold ischemic time on the outcome of kidney transplantation in Dr. Kariadi Hospital Semarang.\u0000 \u0000 \u0000 \u0000 This is an observational, cross-sectional study. The data was collected from medical record of all patients who underwent kidney transplantation from January 2014 until December 2018 and the level of creatinine and urine production before and after transplantation was documented. A total of 28 patients were registered and completed the inclusion criteria. The results of the study were tabulated and statistical analysis was performed using SPSS 23.0. The relationship was declared meaningful if p = 0.05 was obtained.\u0000 \u0000 \u0000 \u0000 From the analysis of the research that has been done using the Pearson correlation test and hypothesis test Wilcoxon, it was found that there was a relationship between ischemic time and a decrease in creatinine level from r = -0.4489 with a value of p = 0.008. From the analysis of the research, a relationship between ischemic time and urine production was found after transplantation with a value of r = -0.562 and a value of p = 0.002.\u0000 \u0000 \u0000 \u0000 The results of this study show a strong correlation between the length of total ischemic time with a decrease in creatinine and urine production which means that the longer ischemic time, the lower the decrease in creatinine levels and the lesser the urine production.\u0000","PeriodicalId":38952,"journal":{"name":"Open Urology and Nephrology Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48916481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-30DOI: 10.2174/1874303x01912010060
L. V. Thang, N. Kien, P. N. H. Tuan, Nguyen Tien Dung, T. Q. Kien, D. M. Ha, P. Q. Toan, Nguyen T. T. Ha, D. T. Van, Nguyen Van Duc, Vu Xuan Nghia, N. H. Dung, N. Huong, H. T. Vinh, L. T. Ha
To evaluate the predictive value of urine Neutrophil Gelatinase-Associated Lipocalin (NGAL) measured at the time of admission during the recovery from Acute Kidney Injury (AKI) after 90 days. This study includes 101 adult patients admitted to the Intensive Care Unit (ICU) who were diagnosed as AKI (96 patients had been collected 24-hour urine and 5 patients with anuria). Acute kidney injury was diagnosed using the Acute Kidney Injury Network (AKIN) criteria. Urine NGAL was measured at admission using the BioVendor Human Lipocalin-2/NGAL ELISA. The ratio of complete recovery patients after 90 days reached 71.9%. The mean of urine NGAL concentration in the recovery group was 242.04 ng/ml, lower significantly than that of non-recovery patients (371.1 ng/ml), p=0.007. At the cut-off value for 740.03 ng/ml, urine NGAL measured at admission predicted complete recovery with the area under the curve of ROC for urine NGAL = 0.888, p<0.001. Based on the multivariate regression analysis, serum urea, serum creatinine and urine NGAL were independent factors that effected the proportion of recovery in AKI patients (OR=0.856, p=0.023; OR=1.014, p=0.012 and OR=0.993, p<0.001, respectively). Serum urea, serum creatinine and urine NGAL were independent factors that effected the proportion of recovery in AKI patients. Urine NGAL in AKI patients measured at the time of the admission time to ICU can be used as a prognostic biomarker of recovery.
{"title":"Urine Neutrophil Gelatinase-Associated Lipocalin Measured at Admission to Predict Recovery from Acute Kidney Injury of Vietnamese ICU Patients","authors":"L. V. Thang, N. Kien, P. N. H. Tuan, Nguyen Tien Dung, T. Q. Kien, D. M. Ha, P. Q. Toan, Nguyen T. T. Ha, D. T. Van, Nguyen Van Duc, Vu Xuan Nghia, N. H. Dung, N. Huong, H. T. Vinh, L. T. Ha","doi":"10.2174/1874303x01912010060","DOIUrl":"https://doi.org/10.2174/1874303x01912010060","url":null,"abstract":"\u0000 \u0000 To evaluate the predictive value of urine Neutrophil Gelatinase-Associated Lipocalin (NGAL) measured at the time of admission during the recovery from Acute Kidney Injury (AKI) after 90 days.\u0000 \u0000 \u0000 \u0000 This study includes 101 adult patients admitted to the Intensive Care Unit (ICU) who were diagnosed as AKI (96 patients had been collected 24-hour urine and 5 patients with anuria). Acute kidney injury was diagnosed using the Acute Kidney Injury Network (AKIN) criteria. Urine NGAL was measured at admission using the BioVendor Human Lipocalin-2/NGAL ELISA.\u0000 \u0000 \u0000 \u0000 The ratio of complete recovery patients after 90 days reached 71.9%. The mean of urine NGAL concentration in the recovery group was 242.04 ng/ml, lower significantly than that of non-recovery patients (371.1 ng/ml), p=0.007. At the cut-off value for 740.03 ng/ml, urine NGAL measured at admission predicted complete recovery with the area under the curve of ROC for urine NGAL = 0.888, p<0.001. Based on the multivariate regression analysis, serum urea, serum creatinine and urine NGAL were independent factors that effected the proportion of recovery in AKI patients (OR=0.856, p=0.023; OR=1.014, p=0.012 and OR=0.993, p<0.001, respectively).\u0000 \u0000 \u0000 \u0000 Serum urea, serum creatinine and urine NGAL were independent factors that effected the proportion of recovery in AKI patients. Urine NGAL in AKI patients measured at the time of the admission time to ICU can be used as a prognostic biomarker of recovery.\u0000","PeriodicalId":38952,"journal":{"name":"Open Urology and Nephrology Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45973675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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