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Potential for Using EGFR Expression in Rhabdomyosarcoma, Osteosarcoma and Ewing’s Sarcoma: Clinicopathological and Prognostic Significance 在横纹肌肉瘤、骨肉瘤和尤文氏肉瘤中使用EGFR表达的潜力:临床病理和预后意义
Q4 Multidisciplinary Pub Date : 2022-01-01 DOI: 10.37575/b/med/220003
H. Huwait, Hatim Almaghrabi, M. Gayyed, Hanan M Abd Elmoneim
Sarcomas are a heterogeneous group of malignant tumors that arise from mesenchymal cells and can arise anywhere in the body, whether it is soft tissue or bone. Epidermal growth factor receptor (EGFR) expression in pediatric sarcomas is explored in the current study. A key feature of EGFRs is their general involvement in signal transduction and oncogenesis, making them one of the most studied receptor protein-tyrosine kinase families. The study included 104 archived formalin-fixed paraffin-embedded blocks assessed using immunohistochemical stains for EGFR expression in rhabdomyosarcoma, osteosarcoma, and Ewing's sarcoma. EGFR gene copy number was analyzed by dual silver in situ hybridization (DISH). EGFR was positively expressed in 56.7% of pediatric sarcoma. Immunostaining for EGFR was significantly associated with deep large tumors, stage, and histologic grade. Significantly, lower chances of overall survival were observed with elevated levels of EGFR five years post-diagnosis. EGFR staining identified independent risk factors for poor patient outcomes. The results of in situ hybridization did not indicate EGFR gene amplification in any of the cases assessed. EGFR overexpression was an independent predictor of pediatric sarcoma outcome, which is highly associated with histologic grade and stage. Results indicate EGFR inhibitors should be potentiated and directed against pediatric sarcoma. KEYWORDS EGFR, Ewing’s sarcoma, osteosarcoma, rhabdomyosarcoma
肉瘤是一种异质性的恶性肿瘤,起源于间充质细胞,可以出现在身体的任何部位,无论是软组织还是骨骼。本研究探讨了表皮生长因子受体(EGFR)在小儿肉瘤中的表达。egfr的一个关键特征是它们普遍参与信号转导和肿瘤发生,使它们成为研究最多的受体蛋白-酪氨酸激酶家族之一。该研究包括104个存档的福尔马林固定石蜡包埋块,使用免疫组织化学染色评估横纹肌肉瘤、骨肉瘤和尤文氏肉瘤中EGFR的表达。双银原位杂交(dual silver in situ hybridization, DISH)分析EGFR基因拷贝数。EGFR在56.7%的儿童肉瘤中呈阳性表达。EGFR免疫染色与深部大肿瘤、分期和组织学分级显著相关。值得注意的是,诊断后5年EGFR水平升高,总生存率降低。EGFR染色确定了患者预后不良的独立危险因素。原位杂交结果没有显示EGFR基因扩增在任何评估的情况下。EGFR过表达是儿童肉瘤预后的独立预测因子,与组织学分级和分期高度相关。结果表明,EGFR抑制剂应增强和直接针对儿童肉瘤。关键词segfr,尤文氏肉瘤,骨肉瘤,横纹肌肉瘤
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引用次数: 0
Detecting Hadith Authenticity Using a Deep-learning Approach 利用深度学习方法检测圣训的真实性
Q4 Multidisciplinary Pub Date : 2022-01-01 DOI: 10.37575/b/sci/210084
Eshrag A. Refaee
Hadith is a collection of texts containing sayings of the prophet Muhammad, which, along with accounts of his daily practice, constitute the second major source of legislation for Muslims after the Holy Koran. The Hadith collection comprises thousands of text pieces transferred over the years by many narrators with varying degrees of credibility. Hadith scholars are faced with the challenge of assessing the degree of a specific Hadith’s authenticity to classify the Hadith as Sahih (fully authentic and accepted) or Daif (rejected). Automatic Hadith classification has been addressed in the literature; however, the results vary and are not directly comparable, as no dataset has been made available for benchmarking. In addition, no previous work has utilised deep-learning (DL) approaches for Hadith classification. This work contributes by 1) collecting and publicly releasing a benchmark Hadith dataset of almost 4,000 Hadith texts to facilitate future research, 2) exploring DL model performance on binary Hadith classification tasks, and 3) benchmarking traditional machine learning against DL models. Our best results were recorded with an ARBERT DL model that provided an accuracy score of 91.56%. KEYWORDS Hadith classification; deep learning; Classical Arabic; machine learning; Hadith science; Hadith authenticity
《圣训》是包含先知穆罕默德语录的文本集合,连同他的日常实践,构成了穆斯林继《古兰经》之后的第二大法律来源。《圣训集》由数千篇文字组成,这些文字是许多叙述者多年来以不同程度的可信度转述的。圣训学者面临着评估特定圣训真实性程度的挑战,将圣训分类为Sahih(完全真实并被接受)或Daif(被拒绝)。自动圣训分类已经在文献中提到;然而,结果各不相同,不能直接比较,因为没有数据集可用于基准测试。此外,以前的工作没有使用深度学习(DL)方法进行哈迪斯分类。这项工作的贡献包括:1)收集并公开发布一个包含近4000个Hadith文本的基准Hadith数据集,以促进未来的研究;2)探索深度学习模型在二元Hadith分类任务上的性能;3)针对深度学习模型对传统机器学习进行基准测试。我们最好的结果是用ARBERT DL模型记录的,它提供了91.56%的准确率。KEYWORDSHadith分类;深度学习;古典阿拉伯语;机器学习;穆罕默德言行录科学;穆罕默德言行录真实性
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引用次数: 0
Ultra-Short Pulses Generation of Free Electron Laser 自由电子激光的超短脉冲产生
Q4 Multidisciplinary Pub Date : 2022-01-01 DOI: 10.37575/b/sci/220045
T. Al-Aish, H. Kamil
The major problem facing the development of civil and military laser applications lies in the attempts to obtain short pulses close to the length of the bond that connects the atoms of certain materials. In this paper, an executable program has been constructed to simulate and analyze the generation of ultra-short free electron laser pulses; it contains several parameters directing the creation of short pulses within a time duration of femtoseconds (fs). On analyzing the simulation results, it can be concluded that it is possible to generate ultra-short pulses with a duration of about 7.4 – 87.4 fs with the storage ring free-electron laser Fabry–Perot resonator with noticeably short wavelengths (11.4–190.2) for the output laser beam. KEYWORDS Homogenous broadening; SR-FEL; undulator; energy spread gain; Q- switching
发展民用和军用激光应用所面临的主要问题在于,如何获得接近连接某些材料原子的键长度的短脉冲。本文编制了一个可执行程序来模拟和分析超短自由电子激光脉冲的产生;它包含几个参数,指导在飞秒(fs)的时间内创建短脉冲。通过对仿真结果的分析,可以得出结论,使用具有明显短波长(11.4 ~ 190.2)的存储环自由电子激光器法布里-珀罗谐振器输出激光束,可以产生持续时间约为7.4 ~ 87.4 fs的超短脉冲。KEYWORDSHomogenous扩大;SR-FEL;波纹机;能量扩散增益;Q -开关
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引用次数: 0
New Records of Rare Species of Marine Invertebrates in the Eastern Mediterranean, Syria 叙利亚东地中海稀有海洋无脊椎动物新记录
Q4 Multidisciplinary Pub Date : 2022-01-01 DOI: 10.37575/b/sci/220044
I. Ammar, Yara Hmaesha
Conducting further research and exerting more effort into field studies will aid the detection and recording of new, rare species of invertebrates in the Mediterranean and allow the examination of their biological and environmental characteristics. This article provides information on four species of sea crab (one of which is alien), two species of sea star, one species of sea urchin and two species of octopus, which have all been documented for the first time in Syrian waters. Samples were collected by fishing nets from a coastal area at medium depths (20–630 meters) from Ras al-Basit, Lattakia and Banias during 2020 and 2021. These species are: Actaea savignii (H. Milne Edwards, 1834); Dromia personata (Linnaeus, 1758);Geryon longipes (A. Milne-Edwards, 1882); Homola barbata (Fabricius, 1793); Peltaster placenta (Müller and Troschel, 1842); Chaetaster longipes (Bruzelius, 1805); Sphaerechinus granularis (Lamarck, 1816); Tremoctopus violaceus (Delle Chiaje, 1830);Ocythoe tuberculate (Rafinesque, 1814). Documenting the presence of these rare species is very important from an environmental and scientific perspective, and recording more of them requires coordination with the marine fishing sector in Syria. KEYWORDS Cephalopods, crustaceans, echinoderms, marine biodiversity, non-indigenous species,zoobenthos
进行进一步的研究和在实地研究方面作出更大的努力将有助于发现和记录地中海地区新的、稀有的无脊椎动物物种,并审查它们的生物和环境特征。本文提供了关于四种海蟹(其中一种是外来的)、两种海星、一种海胆和两种章鱼的信息,这些都是首次在叙利亚水域被记录在案。在2020年和2021年期间,通过渔网在Ras al-Basit、Lattakia和Banias的中等深度(20-630米)沿海地区收集了样本。这些物种是:Actaea savignii (H. Milne Edwards, 1834);《人的幻影》(林奈,1758);《格里翁·朗格普斯》(A. Milne-Edwards, 1882);barbara (fabicius, 1793);Peltaster胎盘(m ller and Troschel, 1842);《骗子》(Bruzelius, 1805);Sphaerechinus granularis (Lamarck, 1816);violaceus (Delle Chiaje, 1830); cythos tuberculate (Rafinesque, 1814)。从环境和科学的角度来看,记录这些稀有物种的存在非常重要,记录更多的珍稀物种需要与叙利亚的海洋渔业部门进行协调。关键词头足类,甲壳类,棘皮动物,海洋生物多样性,外来物种,底栖动物
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引用次数: 1
The Impact of Initial Public Offerings’ Characteristics on Real Estate Investment Trusts’ Underpricing: The Saudi Context 首次公开发行(ipo)特征对房地产投资信托定价过低的影响:以沙特为例
Q4 Multidisciplinary Pub Date : 2022-01-01 DOI: 10.37575/h/mng/220022
Hessa Albarrak, Abdullah Aljughaiman2, Mohammed S. Albarrak
In recent years, many Real Estate Investment Trusts (REIT) have issued to initial public offerings (IPO) in the Saudi Stock Exchange “Tadawul.” Occasionally, trust fund issuers such as REITs may face challenges in selling their shares to the public. One of the challenges related to underpricing is trading the stock on the first day of the market. This study investigates the relationship between REIT characteristics and share underpricing for a sample of REITs that are listed on the Saudi Stock Exchange “Tadawul.” The purpose of the study is to focus on one of the challenges that is related to the IPOs of REITs. Using a sample of 17 IPOs of REITs listed on the Saudi Arabian Stock Exchange “Tadawul” for the period between 2016 and 2020, we show significant negative associations between the number of IPO underwriters, number of shares subscribed, and the firms’ dividend payouts and REITs’ underpricing. The result also shows a significant positive association between the number of subscription days and REITs’ underpricing. The research should provide significant implications for regulators and market participants in the light of the public offering and the REIT sector. KEYWORDS public offering, financial performance, real estate, investment trusts, stock exchange, Tadawul
近年来,许多房地产投资信托基金(REIT)已在沙特证券交易所“Tadawul”首次公开募股(IPO)。偶尔,信托基金发行人(如REITs)在向公众出售股票时可能会面临挑战。与定价过低有关的挑战之一是在上市首日交易股票。本研究以在沙特证券交易所“Tadawul”上市的REIT为样本,探讨REIT特征与股票抑价之间的关系。本研究的目的是关注与房地产投资信托基金ipo相关的挑战之一。以2016年至2020年期间在沙特阿拉伯证券交易所“Tadawul”上市的17家REITs IPO为样本,我们发现IPO承销商数量、认购股票数量与公司派息和REITs低估之间存在显著的负相关关系。结果还显示,认购天数与REITs的低定价之间存在显著的正相关关系。该研究将为监管机构和市场参与者在公开发行和房地产投资信托行业提供重要的启示。关键词:公开发行,财务业绩,房地产,投资信托,证券交易所,Tadawul
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引用次数: 0
The Philosophy of Requesting in Official Letters: Arab Higher Educational Institutions 公文中的请求哲学:阿拉伯高等教育机构
Q4 Multidisciplinary Pub Date : 2022-01-01 DOI: 10.37575/h/lng/220023
Abdulaziz Alhulaybi
This study analyses requesting as a pragmatic speech act. Pragmatics study language usage by examining meaning as understood in the speaker’s mind and receiver’s interpretation and focusing on what people mean by their words. In addition, this study investigates the use of requests by identifying their strategies and supportive moves. This is achieved by examining speech acts in the communications of a specific educational institution: King Faisal University. The data obtained are analysed pragmatically in accordance with, in particular, politeness theory and the concept of face. This provides us with a clear vision of the use of requests in a specific social and cultural environment and enables us to identify the strategies and supportive moves (internal and external) that speakers employ to successfully perform their speech acts. The results show the prevalence of direct strategy usage with their four models, avoidance of directness (particularly through the use of hints), interest in using external supportive moves in requests and a lack of internal supportive moves to support and mitigate requests. In general, the data shows structural similarity, which indicates the existence of a specific perception for communications in the institution.
本研究将请求作为一种语用言语行为进行分析。语用学研究语言的用法,通过考察说话者的思想和接受者的解释来理解意义,并关注人们所说的话的意思。此外,本研究通过确定请求的策略和支持动作来调查请求的使用。这是通过检查特定教育机构:费萨尔国王大学的交流中的言语行为来实现的。根据礼貌理论和面子概念对所得数据进行语用分析。这为我们提供了在特定的社会和文化环境中使用请求的清晰视野,使我们能够识别说话者为成功执行言语行为所采用的策略和支持动作(内部和外部)。结果显示,在他们的四个模型中,直接策略的使用普遍存在,避免直接(特别是通过使用暗示),在请求中使用外部支持动作的兴趣,以及缺乏内部支持动作来支持和减轻请求。总的来说,数据显示结构相似性,这表明机构中存在特定的通信感知。
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引用次数: 0
The Impact of Climate Change on Human Rights: The Saudi Context 气候变化对人权的影响:以沙特为例
Q4 Multidisciplinary Pub Date : 2022-01-01 DOI: 10.37575/h/law/220013
N. Abbas
Climate change is a global as well as a local issue due to its impact on both international and local levels. Climate change is defined as the change that affects the components of the environment surrounding humans, such as air, water, and soil. Accordingly, it harmfully impacts some of the most basic determinants of health, including clean air, clean water, clean food, adequate shelter, and protection from disease. The study problem emerges from the discussion on the impact of climate change on human rights in international law and the Saudi system. This study sought to demonstrate and discuss the impact of climate change on human rights and showed that climate change influences all aspects of life that directly and indirectly affect human rights, for instance, air and water pollution. Undoubtedly, climate change harms human health and life and even damages plants irrigated by polluted water. Consequently, green Saudi Arabia achieving the goals of Vision 2030 of protecting human rights from climate change that comes on green spaces from any aspect of the environment, like water, air, or soil. Therefore, which, in turn, has harmful effects on life in general, health, water, food, and housing.
由于气候变化对国际和地方的影响,它既是一个全球性问题,也是一个地方性问题。气候变化被定义为影响人类周围环境组成部分的变化,如空气、水和土壤。因此,它有害地影响到一些最基本的健康决定因素,包括清洁的空气、清洁的水、清洁的食物、适当的住房和免受疾病的保护。这个研究问题是在讨论气候变化对国际法和沙特体制下人权的影响时产生的。这项研究试图证明和讨论气候变化对人权的影响,并表明气候变化影响直接和间接影响人权的生活的所有方面,例如空气和水污染。毫无疑问,气候变化危害了人类的健康和生命,甚至损害了受污染的水灌溉的植物。因此,绿色沙特阿拉伯实现了2030年愿景的目标,即保护人权免受气候变化的影响,气候变化来自环境的任何方面,如水、空气或土壤。因此,这反过来又对生活、健康、水、食物和住房产生有害影响。
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引用次数: 0
Egyptian Imports from Food Groups in Light of COVID-19: An Econometric Study 鉴于COVID-19,埃及从食品集团进口:一项计量经济学研究
Q4 Multidisciplinary Pub Date : 2022-01-01 DOI: 10.37575/b/agr/220017
M. Ali, E. Ahmed
This study aims to identify the extent to which COVID-19 impacted Egyptian imports. It includes two main sections. The first section identifies the repercussions of COVID-19 on some global and local economic indicators – especially the recession that most of the world’s economies are experiencing in light of the continuing COVID-19 outbreaks. The Egyptian economy achieved a general growth rate in 2020, at a time when the entire world was experiencing economic stagnation; this was due to the Egyptian government’s set of measures and a lack of direction towards a complete closure. The second part examines demand determinants for Egyptian imports of meat, dairy, oils, cereals, sugar and wheat using ARDL models according to the bounds testing approach to cointegration. This was accomplished by studying the extent to which dependent variables have a long-term equilibrium relationship, as well as the value of imports with lag periods, gross domestic products, relative prices, effective real exchange rates, liberalisation policies, COVID-19 effects on imports and forecasting demand for Egyptian imports. KEYWORDS ARDL-UECM, economic growth, exchange rate, relative prices, SARIMA, trade policies
本研究旨在确定COVID-19对埃及进口的影响程度。它包括两个主要部分。第一部分确定了COVID-19对一些全球和地方经济指标的影响,特别是鉴于COVID-19疫情持续,世界大多数经济体正在经历的衰退。埃及经济在2020年实现了总体增长率,而当时整个世界都在经历经济停滞;这是由于埃及政府的一系列措施和缺乏彻底关闭的方向。第二部分根据协整的边界检验方法,使用ARDL模型检查埃及进口肉类、乳制品、油、谷物、糖和小麦的需求决定因素。这是通过研究因变量具有长期均衡关系的程度,以及进口价值与滞后期、国内生产总值、相对价格、有效实际汇率、自由化政策、COVID-19对进口的影响以及预测埃及进口需求来实现的。经济增长,汇率,相对价格,SARIMA,贸易政策
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引用次数: 0
Factors Affecting Students’ Readiness for Flipped Learning: An Innovative Approach 影响学生翻转学习准备的因素:一种创新方法
Q4 Multidisciplinary Pub Date : 2022-01-01 DOI: 10.37575/h/edu/220006
A. Alenezi
This research aims to investigate factors that affect students’ readiness for a flipped learning approach in blended courses. For this purpose, the research has proposed an extensive model to examine the critical factors that could influence students’ readiness for flipped learning, namely technology self-efficacy, course design, learning flexibility, learning management, online interaction and online environment. Moreover, the moderating role of motivation in affecting the relationship between flipped learning readiness and both learning flexibility and learning management has been examined. A quantitative method was adopted, and 240 valid respondents were obtained and utilised for the data analysis. Both structural and measurement models were assessed using the Partial Least Square-Structural Equations Model (PLS-SEM). The results confirmed that all examined factors significantly affected students’ readiness for flipped learning. The interaction–moderation analysis revealed that motivation significantly affected the relationship between the students’ readiness for flipped learning and factors related to learning, namely learning flexibility and learning management. The contribution of this research is considerable in terms of its theoretical and practical implications. Following the addressed limitations, several recommendations and suggestions are made for the future direction of research. KEYWORDS Technology self-efficacy, course design, learning flexibility, learning management, online interaction, online environment
本研究旨在探讨在混合课程中影响学生对翻转学习方法的准备程度的因素。为此,本研究提出了一个广泛的模型来检验可能影响学生翻转学习准备的关键因素,即技术自我效能感、课程设计、学习灵活性、学习管理、在线互动和在线环境。此外,本研究还考察了动机在影响翻转学习准备与学习灵活性和学习管理之间关系中的调节作用。采用定量分析的方法,共获得240名有效调查对象进行数据分析。结构模型和测量模型均采用偏最小二乘结构方程模型(PLS-SEM)进行评估。结果证实,所有被检查的因素显著影响学生的翻转学习准备。交互-调节分析显示,动机显著影响学生翻转学习准备与学习灵活性和学习管理的关系。本研究的贡献在理论和实践意义上都是相当可观的。在指出局限性之后,对未来的研究方向提出了几点建议和建议。关键词科技自我效能感,课程设计,学习灵活性,学习管理,在线互动,在线环境
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引用次数: 0
Orientalists’ Views on the Arabs of the Arabian Peninsula: A Critical Enquiry into the Journey of William Palgrave 东方主义者对阿拉伯半岛阿拉伯人的看法——对威廉·帕尔格雷夫游记的批判性考察
Q4 Multidisciplinary Pub Date : 2022-01-01 DOI: 10.37575/h/his/220201
Khlaif Alshammari
This article sheds light on how the Arabs of the Arabian Peninsula are described in the writings of the English orientalist William Gifford Palgrave (1826-1888). He depicted a lively and vibrant social image of the inhabitants of the Arabian Peninsula. He wrote about their religious, intellectual, moral, political and social aspects. He relied on his travelling throughout the Peninsula to discuss this society, its characteristics, its positives and its negatives. The study investigates the stereotyped image of these Arabs in line with Orientalist experiments specifically in the 19th century. It adopts historical and comparative approaches within his writings away from exaggeration in interpretation. It reveals the dominance of Eurocentrism as a conceptual framework that has had an impact on most of his writings, just like other orientalists in the 19th century. KEYWORDS Arab characteristics, eurocentrism, historical approach, orientalism
本文阐明了英国东方学家威廉·吉福德·帕尔格雷夫(William Gifford Palgrave, 1826-1888)的著作是如何描述阿拉伯半岛的阿拉伯人的。他描绘了阿拉伯半岛居民生动活泼的社会形象。他描写了他们的宗教、知识、道德、政治和社会方面。他依靠他在半岛上的旅行来讨论这个社会,它的特点,它的优点和缺点。本研究以19世纪的东方学实验为背景,考察了这些阿拉伯人的刻板形象。它在他的作品中采用了历史和比较的方法,而不是夸张的解释。它揭示了欧洲中心主义作为一种概念框架的主导地位,这对他的大部分作品都产生了影响,就像19世纪其他东方学家一样。关键词:阿拉伯特征;欧洲中心主义;历史取向
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引用次数: 0
期刊
Scientific Journal of King Faisal University
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