Pub Date : 2020-03-10DOI: 10.3760/CMA.J.ISSN.1005-1201.2020.03.004
Qing Tao, W. Zou, Yanfen Fan, Hailin Shen, Hongdi Du, C. Qian, Feng Zhu, Su Hu, Guang-yu Hao, S. Duan, Chunhong Hu
Objective To investigate the value of pericoronary adipose tissue histogram parameters based on coronary CT angiography (CTA) images for the differentiation of acute coronary syndrome and stable coronary artery disease. Methods The clinical data and CTA images of 93 patients with coronary CTA examination in Suzhou Kowloon Hospital from 2013 to 2018 were analyzed retrospectively. There were 39 patients with acute coronary syndrome (acute coronary syndrome group) and 54 patients with stable coronary artery disease (stable coronary artery disease group). A region of interest (ROI) was drawn around the stenosis of the coronary arteries, with CT attenuation ranging from-190 to -30 HU to exclude non-adipose tissue. The CT attenuation of ROI excluding non-adipose were measured and histogram analysis was performed. The obtained parameters included the mean value, median value and the 5th, 10th, 45th, 55th, 70th and 95th percentiles. The differences in histogram parameters between the two groups were compared, and then the value of each parameter in differentiating acute coronary syndrome and stable coronary artery disease was evaluated based on receiver operating characteristic (ROC) analysis. The stepwise regression of multivariate logistic regression analysis was used to identify the useful features and establish the final prediction model. The ROC curve of the final model was calculated and its value was analyzed. Results The mean, median and the 5th, 10th, 45th, 55th,70th and 95th percentile differences between the acute coronary syndrome group and the stable coronary artery disease group were statistically significant (all P<0.05). The ROC curve for the median and the 95th percentile had the same area under curve (AUC) of 0.73. The sensitivity, specificity and AUC of the diagnostic model established by multiple logistic regression were 82.1%, 89.1% and 0.90 respectively. Conclusion CT attenuation histogram of pericoronary adipose tissue is of high value in differentiating acute coronary syndrome from stable coronary artery disease. Key words: Coronary disease; Tomography, X-ray computed; Adipose tissue
{"title":"Preliminary study on the value of pericoronary adipose tissue histogram parameters for the differentiation of acute coronary syndrome and stable coronary artery disease","authors":"Qing Tao, W. Zou, Yanfen Fan, Hailin Shen, Hongdi Du, C. Qian, Feng Zhu, Su Hu, Guang-yu Hao, S. Duan, Chunhong Hu","doi":"10.3760/CMA.J.ISSN.1005-1201.2020.03.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1005-1201.2020.03.004","url":null,"abstract":"Objective \u0000To investigate the value of pericoronary adipose tissue histogram parameters based on coronary CT angiography (CTA) images for the differentiation of acute coronary syndrome and stable coronary artery disease. \u0000 \u0000 \u0000Methods \u0000The clinical data and CTA images of 93 patients with coronary CTA examination in Suzhou Kowloon Hospital from 2013 to 2018 were analyzed retrospectively. There were 39 patients with acute coronary syndrome (acute coronary syndrome group) and 54 patients with stable coronary artery disease (stable coronary artery disease group). A region of interest (ROI) was drawn around the stenosis of the coronary arteries, with CT attenuation ranging from-190 to -30 HU to exclude non-adipose tissue. The CT attenuation of ROI excluding non-adipose were measured and histogram analysis was performed. The obtained parameters included the mean value, median value and the 5th, 10th, 45th, 55th, 70th and 95th percentiles. The differences in histogram parameters between the two groups were compared, and then the value of each parameter in differentiating acute coronary syndrome and stable coronary artery disease was evaluated based on receiver operating characteristic (ROC) analysis. The stepwise regression of multivariate logistic regression analysis was used to identify the useful features and establish the final prediction model. The ROC curve of the final model was calculated and its value was analyzed. \u0000 \u0000 \u0000Results \u0000The mean, median and the 5th, 10th, 45th, 55th,70th and 95th percentile differences between the acute coronary syndrome group and the stable coronary artery disease group were statistically significant (all P<0.05). The ROC curve for the median and the 95th percentile had the same area under curve (AUC) of 0.73. The sensitivity, specificity and AUC of the diagnostic model established by multiple logistic regression were 82.1%, 89.1% and 0.90 respectively. \u0000 \u0000 \u0000Conclusion \u0000CT attenuation histogram of pericoronary adipose tissue is of high value in differentiating acute coronary syndrome from stable coronary artery disease. \u0000 \u0000 \u0000Key words: \u0000Coronary disease; Tomography, X-ray computed; Adipose tissue","PeriodicalId":39377,"journal":{"name":"Zhonghua fang she xue za zhi Chinese journal of radiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46727638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Primary pulmonary osteosarcoma: a case report","authors":"Zhiying Qi","doi":"10.3760/CMA.J.ISSN.1005-1201.2020.03.015","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1005-1201.2020.03.015","url":null,"abstract":"本文报道肺原发性骨肉瘤1例。患者男，77岁，CT表现为左肺下叶团块状软组织密度影，密度不均，内见多发囊状低密度影及点片状致密影，增强扫描实性部分呈不均匀明显强化，囊性部分未见强化。病理诊断：肺原发性骨肉瘤。","PeriodicalId":39377,"journal":{"name":"Zhonghua fang she xue za zhi Chinese journal of radiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45538030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-10DOI: 10.3760/CMA.J.ISSN.1005-1201.2020.03.002
Ming-ping Sun, Qing-hua Chen, Xiaolin Xu, Zhenchao Sun, Yaping Su, Bin Li, W. Wei, J. Xian
Objective To compare MRI findings of uveal melanomas and other intraocular masses in adults and to evaluate the optimal MRI features for the differential diagnosis. Methods The MRI data of 254 patients with intraocular masses confirmed by histopathologic or clinical follow-up results from March 2005 to December 2015 in Beijing Tongren Hospital, Capital Medical University was analyzed retrospectively. A total of 128 patients with uveal melanoma and 126 patients with other intraocular masses were enrolled. MRI findings of the masses including the location, shape, margin, signal intensity on T1WI and T2WI compared to the gray matter and vitreous body, homogeneity and degree of enhancement of the mass, secondary retinal detachment, height, and ratio of basal diameter to height were compared between uveal melanoma and other intraocular masses by χ2 test or independent t test. The logistic regression analysis was performed to identify the most discriminating MRI features. The diagnostic performance of different predictive models was analyzed by receiver operating characteristic (ROC) curve. The model of multiple parameters was established by logistic analysis, and the diagnostic efficacy was evaluated. Results The location, shape, margin, signal intensity on T1WI and T2WI compared to the gray matter and vitreous body, homogeneity and degree of enhancement of the mass, secondary retinal detachment, height and ratio of basal diameter to height were significantly different between the uveal melanoma and other intraocular masses (all P<0.05). The results of logistic regression analysis showed that the signal intensity on T1WI and T2WI compared to the gray matter, height, shape, location, degree of enhancement of the mass, and secondary retinal detachment were associated with higher likelihood of uveal melanoma. The mass with hypointense on T2WI (compared with gray matter) was the best MRI feature in the differential diagnosis of uveal melanoma and other intraocular masses (odds ratio 12.237), with the accuracy of 86.2%. The diagnostic accuracy of low signal on T2WI and high signal on T1WI (compared with gray matter) was significantly higher than those of vitreous (Delong test, P<0.001). The sensitivity, specificity and accuracy of the combination of height, degree of enhancement, T1WI and T2WI signal compared to the gray matter were 90.6%, 92.1% and 96.1%, respectively. The diagnostic performance of combination features was higher than that of each single sign (P<0.001). Conclusion MRI features including the signal intensity on T1WI and T2WI compared to the gray matter, height, shape, degree of enhancement of the mass, and secondary retinal detachment are helpful in the differential diagnosis between uveal melanoma and other intraocular masses. In addition, the gray matter as the reference is superior to the vitreous body in the evaluation of the signal intensity of intraocular masses. Key words: Melanoma; Eye neoplasms; Magnetic r
{"title":"Value of MRI in the differential diagnosis of uveal melanoma and other intraocular masses in adults","authors":"Ming-ping Sun, Qing-hua Chen, Xiaolin Xu, Zhenchao Sun, Yaping Su, Bin Li, W. Wei, J. Xian","doi":"10.3760/CMA.J.ISSN.1005-1201.2020.03.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1005-1201.2020.03.002","url":null,"abstract":"Objective \u0000To compare MRI findings of uveal melanomas and other intraocular masses in adults and to evaluate the optimal MRI features for the differential diagnosis. \u0000 \u0000 \u0000Methods \u0000The MRI data of 254 patients with intraocular masses confirmed by histopathologic or clinical follow-up results from March 2005 to December 2015 in Beijing Tongren Hospital, Capital Medical University was analyzed retrospectively. A total of 128 patients with uveal melanoma and 126 patients with other intraocular masses were enrolled. MRI findings of the masses including the location, shape, margin, signal intensity on T1WI and T2WI compared to the gray matter and vitreous body, homogeneity and degree of enhancement of the mass, secondary retinal detachment, height, and ratio of basal diameter to height were compared between uveal melanoma and other intraocular masses by χ2 test or independent t test. The logistic regression analysis was performed to identify the most discriminating MRI features. The diagnostic performance of different predictive models was analyzed by receiver operating characteristic (ROC) curve. The model of multiple parameters was established by logistic analysis, and the diagnostic efficacy was evaluated. \u0000 \u0000 \u0000Results \u0000The location, shape, margin, signal intensity on T1WI and T2WI compared to the gray matter and vitreous body, homogeneity and degree of enhancement of the mass, secondary retinal detachment, height and ratio of basal diameter to height were significantly different between the uveal melanoma and other intraocular masses (all P<0.05). The results of logistic regression analysis showed that the signal intensity on T1WI and T2WI compared to the gray matter, height, shape, location, degree of enhancement of the mass, and secondary retinal detachment were associated with higher likelihood of uveal melanoma. The mass with hypointense on T2WI (compared with gray matter) was the best MRI feature in the differential diagnosis of uveal melanoma and other intraocular masses (odds ratio 12.237), with the accuracy of 86.2%. The diagnostic accuracy of low signal on T2WI and high signal on T1WI (compared with gray matter) was significantly higher than those of vitreous (Delong test, P<0.001). The sensitivity, specificity and accuracy of the combination of height, degree of enhancement, T1WI and T2WI signal compared to the gray matter were 90.6%, 92.1% and 96.1%, respectively. The diagnostic performance of combination features was higher than that of each single sign (P<0.001). \u0000 \u0000 \u0000Conclusion \u0000MRI features including the signal intensity on T1WI and T2WI compared to the gray matter, height, shape, degree of enhancement of the mass, and secondary retinal detachment are helpful in the differential diagnosis between uveal melanoma and other intraocular masses. In addition, the gray matter as the reference is superior to the vitreous body in the evaluation of the signal intensity of intraocular masses. \u0000 \u0000 \u0000Key words: \u0000Melanoma; Eye neoplasms; Magnetic r","PeriodicalId":39377,"journal":{"name":"Zhonghua fang she xue za zhi Chinese journal of radiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42428874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The author reports a rare case of multiple organ primary extranodal lymphoma, male, 63 years old. CT examination revealed multiple nodules or masses in multiple organs (lung, pericardium, pancreas, gallbladder, spine) of the chest and abdomen. The shape, density, and signal of the lesions were similar on CT and MRI, and the imaging manifestations had obvious characteristics. The final pathological diagnosis was lymphoma, and after treatment, it improved significantly.
{"title":"A case report of primary multiple organ extrinsic lymphoma","authors":"Kecheng Zhang, Xiangchun Han, Jian-yu Liu","doi":"10.3760/CMA.J.ISSN.1005-1201.2020.03.014","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1005-1201.2020.03.014","url":null,"abstract":"笔者报道1例罕见的多器官原发结外淋巴瘤，男，63岁。CT检查发现胸部及腹部多器官（肺、心包、胰腺、胆囊、脊柱）多发结节或肿块，CT、MRI上病灶形态、密度及信号相似，影像表现具有明显特点。最终经病理确诊为淋巴瘤，治疗后明显好转。","PeriodicalId":39377,"journal":{"name":"Zhonghua fang she xue za zhi Chinese journal of radiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42887841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-10DOI: 10.3760/CMA.J.ISSN.1005-1201.2020.03.012
Cong Sun, Xin Chen, T. Gong, Xianyun Cai, Yufan Chen, Tuantuan Wang, Hong Tang
Objective To evaluate alterations of periventricular pseudocysts (PVPC) on MRI before and after birth, and to assess the prognosis. Methods We retrospectively analyzed the data of 67 cases that were diagnosed with PVPC on prenatal MRI, of which 24 cases were lost to follow-up, 2 died after birth. A total of 41 surviving fetuses were included in this prognosis study. The gestational ages in this group were between 23 and 39 weeks, with an average of (33±3) weeks.All the subjects underwent brain MRI examinations and Gesell Developmental Scale (GDS) testing between 0-3 years of age. According to the location of cysts and with or without other intracranial and extracranial malformations (dilated ventricles orcerebella medulla, hypoxic-ischemic encephalopathy, TORCH virus infection, corporal hypoplasia, chromosomal malformations and nodular sclerosis) , the patients were divided into four groups: isolated connatal cysts, connatal cysts with additional findings,isolated subependymal pseudocysts, and subependymal pseudocysts with additional findings.The MR images were independently reviewed by two radiologists blinded to the clinical information. Intraclass correlation efficient (ICC) was used to analyze the consistency between the two reviewers.Chi-square test was used to compare the location of cysts (single/bilateral), the number of cyst cavities (single/multi-chamber), and other abnormalities in the connatal cyst group and subependymal cyst group. The mean anteroposterior diameter and mean height of cysts between the connatal cyst group and subependymal cyst group were compared by independent sample t-test.The ANOVA test was used to compare the differences in GDS outcomes among the groups. Multiple comparisons were conducted using the LSD test. Results Inter-observer agreements between the two radiologists were good for the collected data (all ICC>0.75). Eleven isolated connatal cysts and 7 connatal cysts with additional findings became smaller or disappeared, and all had good prognosis. Of the 14 isolated subependymal cysts, 12 became smaller or disappeared, 2 had no change in size, and 13 had good prognosis. The subependymal cysts with additional findings group included 9 cases: 6 became smaller or disappeared, only 3 showed no apparent changes, and 7 had an abnormal outcome. Subependymal cysts with additional findings were significantly reduced and patients demonstrated significant differences compared with the those with isolated subependymal cysts in the development quotients (DQ) of adaptability, large movements, fine movements, personal social interaction, and language DQ (P all 0.05). When associated with additional findings, connatal cysts and subependymal cysts could induce significant different DQ outcome (P all<0.05). Conclusions Isolated PVPC usually become smaller or disappeared and have a benign presentation after birth, whereas patients with subependymal cysts with additional findings usually have a poor prognosis.
{"title":"Evaluation of the neurodevelopment outcome of prenatally diagnosed periventricular pseudocysts using MRI","authors":"Cong Sun, Xin Chen, T. Gong, Xianyun Cai, Yufan Chen, Tuantuan Wang, Hong Tang","doi":"10.3760/CMA.J.ISSN.1005-1201.2020.03.012","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1005-1201.2020.03.012","url":null,"abstract":"Objective \u0000To evaluate alterations of periventricular pseudocysts (PVPC) on MRI before and after birth, and to assess the prognosis. \u0000 \u0000 \u0000Methods \u0000We retrospectively analyzed the data of 67 cases that were diagnosed with PVPC on prenatal MRI, of which 24 cases were lost to follow-up, 2 died after birth. A total of 41 surviving fetuses were included in this prognosis study. The gestational ages in this group were between 23 and 39 weeks, with an average of (33±3) weeks.All the subjects underwent brain MRI examinations and Gesell Developmental Scale (GDS) testing between 0-3 years of age. According to the location of cysts and with or without other intracranial and extracranial malformations (dilated ventricles orcerebella medulla, hypoxic-ischemic encephalopathy, TORCH virus infection, corporal hypoplasia, chromosomal malformations and nodular sclerosis) , the patients were divided into four groups: isolated connatal cysts, connatal cysts with additional findings,isolated subependymal pseudocysts, and subependymal pseudocysts with additional findings.The MR images were independently reviewed by two radiologists blinded to the clinical information. Intraclass correlation efficient (ICC) was used to analyze the consistency between the two reviewers.Chi-square test was used to compare the location of cysts (single/bilateral), the number of cyst cavities (single/multi-chamber), and other abnormalities in the connatal cyst group and subependymal cyst group. The mean anteroposterior diameter and mean height of cysts between the connatal cyst group and subependymal cyst group were compared by independent sample t-test.The ANOVA test was used to compare the differences in GDS outcomes among the groups. Multiple comparisons were conducted using the LSD test. \u0000 \u0000 \u0000Results \u0000Inter-observer agreements between the two radiologists were good for the collected data (all ICC>0.75). Eleven isolated connatal cysts and 7 connatal cysts with additional findings became smaller or disappeared, and all had good prognosis. Of the 14 isolated subependymal cysts, 12 became smaller or disappeared, 2 had no change in size, and 13 had good prognosis. The subependymal cysts with additional findings group included 9 cases: 6 became smaller or disappeared, only 3 showed no apparent changes, and 7 had an abnormal outcome. Subependymal cysts with additional findings were significantly reduced and patients demonstrated significant differences compared with the those with isolated subependymal cysts in the development quotients (DQ) of adaptability, large movements, fine movements, personal social interaction, and language DQ (P all 0.05). When associated with additional findings, connatal cysts and subependymal cysts could induce significant different DQ outcome (P all<0.05). \u0000 \u0000 \u0000Conclusions \u0000Isolated PVPC usually become smaller or disappeared and have a benign presentation after birth, whereas patients with subependymal cysts with additional findings usually have a poor prognosis.","PeriodicalId":39377,"journal":{"name":"Zhonghua fang she xue za zhi Chinese journal of radiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47448686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-10DOI: 10.3760/CMA.J.ISSN.1005-1201.2020.03.009
Shuai Zhang, Lianxiang Xiao, N. Jian, Hui Zhao, Mimi Tian, Guan Li, Xiangtao Lin
Objective To assess the change rules of fetal cervical, thoracic and lumbar spinal volume and centrum volume with gestational ages. Methods The 3.0 T MRI was performed on 55 fetal specimens ranging from 17 to 42 gestational weeks with sequence of three dimensional T2WI. Among 55 samples, 20 samples were obtained from spontaneous abortion of pregnant women and 35 samples were obtained from induced labor of mothers due to serious diseases. The fetal specimen was derived from sectional imaging anatomy research institute of the medical school of Shandong University. No spinal abnormalities were found on CT scans. The cervical, thoracic and lumbar spinal volume was obtained by delineating the vertebral body contour on the reconstructed cross-sectional image with the OsiriX software (www.osirix-viewer.com). And the volume of the cervical, thoracic and lumbar spine was divided by the number of the vertebral bodies to obtain the centrum unit volume. Five lumbar vertebral bodies were measured one by one. Regression analysis was made between the volume of cervical, thoracic and lumbar spine and gestational weeks, and between the volume of lumbar vertebral bodies and gestational weeks to analyze the growth rule of spine. Results (1) The cervical, thoracic and lumbar spine volume increased linearly with gestational ages, and the linear regression equation was as follows: cervical spine volume (mm3) =-1 260.937+81.235×gestational week (R2=0.974, P<0.05), thoracic spine volume (mm3) =-5 933.521+347.503×gestational week (R2=0.972,P<0.05), lumbar spine volume (mm3) =-5 130.912+294.473×gestational week (R2=0.976,P<0.05). (2) The order from large to small of fetal spinal growth rate was thoracic, lumbar and cervical segment. Within the same gestational age, the order from large to small of spinal volume was thoracic, lumbar and cervical segment. The order from large to small of centrum unit volume growth rate was lumbar, thoracic and cervical vertebrae. (3) The volume of each lumbar vertebral body also increased linearly with gestational age. Conclusion The cervical, thoracic and lumbar volume show a good correlation with the gestational weeks in the second and third trimester fatal specimens, and the growth rate of different segments is different. Key words: Fetus; Spine; Bone development; Magnetic resonance imaging
{"title":"MRI study on the normal fetal development of cervical, thoracic and lumbar spines in specimens","authors":"Shuai Zhang, Lianxiang Xiao, N. Jian, Hui Zhao, Mimi Tian, Guan Li, Xiangtao Lin","doi":"10.3760/CMA.J.ISSN.1005-1201.2020.03.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1005-1201.2020.03.009","url":null,"abstract":"Objective \u0000To assess the change rules of fetal cervical, thoracic and lumbar spinal volume and centrum volume with gestational ages. \u0000 \u0000 \u0000Methods \u0000The 3.0 T MRI was performed on 55 fetal specimens ranging from 17 to 42 gestational weeks with sequence of three dimensional T2WI. Among 55 samples, 20 samples were obtained from spontaneous abortion of pregnant women and 35 samples were obtained from induced labor of mothers due to serious diseases. The fetal specimen was derived from sectional imaging anatomy research institute of the medical school of Shandong University. No spinal abnormalities were found on CT scans. The cervical, thoracic and lumbar spinal volume was obtained by delineating the vertebral body contour on the reconstructed cross-sectional image with the OsiriX software (www.osirix-viewer.com). And the volume of the cervical, thoracic and lumbar spine was divided by the number of the vertebral bodies to obtain the centrum unit volume. Five lumbar vertebral bodies were measured one by one. Regression analysis was made between the volume of cervical, thoracic and lumbar spine and gestational weeks, and between the volume of lumbar vertebral bodies and gestational weeks to analyze the growth rule of spine. \u0000 \u0000 \u0000Results \u0000(1) The cervical, thoracic and lumbar spine volume increased linearly with gestational ages, and the linear regression equation was as follows: cervical spine volume (mm3) =-1 260.937+81.235×gestational week (R2=0.974, P<0.05), thoracic spine volume (mm3) =-5 933.521+347.503×gestational week (R2=0.972,P<0.05), lumbar spine volume (mm3) =-5 130.912+294.473×gestational week (R2=0.976,P<0.05). (2) The order from large to small of fetal spinal growth rate was thoracic, lumbar and cervical segment. Within the same gestational age, the order from large to small of spinal volume was thoracic, lumbar and cervical segment. The order from large to small of centrum unit volume growth rate was lumbar, thoracic and cervical vertebrae. (3) The volume of each lumbar vertebral body also increased linearly with gestational age. \u0000 \u0000 \u0000Conclusion \u0000The cervical, thoracic and lumbar volume show a good correlation with the gestational weeks in the second and third trimester fatal specimens, and the growth rate of different segments is different. \u0000 \u0000 \u0000Key words: \u0000Fetus; Spine; Bone development; Magnetic resonance imaging","PeriodicalId":39377,"journal":{"name":"Zhonghua fang she xue za zhi Chinese journal of radiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47680182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-10DOI: 10.3760/CMA.J.ISSN.1005-1201.2020.03.005
Yuan Chen, Zhen-nan Li, Y. An, Z. Hou, Yang Gao, W. Yin, Yitong Yu
Objective To explore risk factors of death in type A intramural hematoma (IMH) patients with conservative therapy and provide important information for clinical risks stratification and decisions-making. Methods This retrospectively study enrolled 130 patients diagnosed with type A IMH in the first CT examination at Fuwai Hospital of Chinese Academy of Medical Sciences and only received conservative therapy between September 2009 and June 2018. Baseline clinical and CT characteristics were recorded. All patients enrolled were followed up. The endpoint was aortic disease-related death, patients were divided into endpoint group and non-endpoint group according to whether or not an endpoint event occurs. Difference between two groups of normally distributed continuous variables, non-normally distributed continuous variables and categorical variables were tested by independent sample t test, Mann-Whitney U test and chi-square test or Fisher′s exact test, respectively. Independent risk factors related to outcomes were assessed with Cox regression analysis and survival analysis. Results In baseline CT data, the mean value of the maximum aortic diameter (MAD) was (49.2±6.9) mm, and the median value of the maximum hematoma thickness (MTH) was 11.0 (8.5, 13.2) mm. There were 56 and 30 patients with ulcer-like projection (ULP) and intramural blood pool (IBP), respectively, which including 36 patients with ULP of ascending aorta, 51 patients with pericardial effusion and 50 patients with pleural effusion. During a median follow-up time of 1 050 (242, 1 949) days, 26 patients experienced aortic disease-related death. Compared with non-endpoint group patients, patients who experienced aortic disease-related death showed older age and larger MAD(t=2.363, 3.640, P=0.020,<0.001), higher proportion of aortic atherosclerosis, ULP and pericardial effusion (χ2=5.275, 6.596, 9.325, P=0.022, 0.010, 0.002).In Cox regression multivariate analysis shows that aortic atherosclerosis [hazard ratio (HR)=3.48, P=0.043], ULP (HR=2.66, P=0.019) and pericardial effusion (HR=2.49, P=0.030) were independent risk factors for aortic disease-related death. Conclusions Aortic atherosclerosis, ULP and pericardial effusion are independent predictors of subsequent aortic disease-related death for type A IMH patients with conservative therapy, identifying these risk factors is helpful for further risk stratification and decisions-making. Key words: Aorta; Hematoma; Tomography, X-ray computed; Risk factor
{"title":"Analysis of risk factors related to death in type A aortic intramural hematoma with conservative therapy","authors":"Yuan Chen, Zhen-nan Li, Y. An, Z. Hou, Yang Gao, W. Yin, Yitong Yu","doi":"10.3760/CMA.J.ISSN.1005-1201.2020.03.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1005-1201.2020.03.005","url":null,"abstract":"Objective \u0000To explore risk factors of death in type A intramural hematoma (IMH) patients with conservative therapy and provide important information for clinical risks stratification and decisions-making. \u0000 \u0000 \u0000Methods \u0000This retrospectively study enrolled 130 patients diagnosed with type A IMH in the first CT examination at Fuwai Hospital of Chinese Academy of Medical Sciences and only received conservative therapy between September 2009 and June 2018. Baseline clinical and CT characteristics were recorded. All patients enrolled were followed up. The endpoint was aortic disease-related death, patients were divided into endpoint group and non-endpoint group according to whether or not an endpoint event occurs. Difference between two groups of normally distributed continuous variables, non-normally distributed continuous variables and categorical variables were tested by independent sample t test, Mann-Whitney U test and chi-square test or Fisher′s exact test, respectively. Independent risk factors related to outcomes were assessed with Cox regression analysis and survival analysis. \u0000 \u0000 \u0000Results \u0000In baseline CT data, the mean value of the maximum aortic diameter (MAD) was (49.2±6.9) mm, and the median value of the maximum hematoma thickness (MTH) was 11.0 (8.5, 13.2) mm. There were 56 and 30 patients with ulcer-like projection (ULP) and intramural blood pool (IBP), respectively, which including 36 patients with ULP of ascending aorta, 51 patients with pericardial effusion and 50 patients with pleural effusion. During a median follow-up time of 1 050 (242, 1 949) days, 26 patients experienced aortic disease-related death. Compared with non-endpoint group patients, patients who experienced aortic disease-related death showed older age and larger MAD(t=2.363, 3.640, P=0.020,<0.001), higher proportion of aortic atherosclerosis, ULP and pericardial effusion (χ2=5.275, 6.596, 9.325, P=0.022, 0.010, 0.002).In Cox regression multivariate analysis shows that aortic atherosclerosis [hazard ratio (HR)=3.48, P=0.043], ULP (HR=2.66, P=0.019) and pericardial effusion (HR=2.49, P=0.030) were independent risk factors for aortic disease-related death. \u0000 \u0000 \u0000Conclusions \u0000Aortic atherosclerosis, ULP and pericardial effusion are independent predictors of subsequent aortic disease-related death for type A IMH patients with conservative therapy, identifying these risk factors is helpful for further risk stratification and decisions-making. \u0000 \u0000 \u0000Key words: \u0000Aorta; Hematoma; Tomography, X-ray computed; Risk factor","PeriodicalId":39377,"journal":{"name":"Zhonghua fang she xue za zhi Chinese journal of radiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44760935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To investigate the changes of liver spin-lattice relaxation time (T1rho) values in the rotating frame in the progression and regression of carbon tetrachloride (CCl4)-induced model rats with liver fibrosis and the diagnostic values for staging liver fibrosis. Methods Eighty rats were prospectively enrolled and randomly divided into the CCl4 group (n=49), the regression group (n=20) and the control group (n=11). All rats were labeled and then examined using MRI at baseline. The liver fibrosis model was established by subcutaneous injection of 40% CCl4 in hackles. The CCl4 group underwent black-blood T1rho imaging at the end of the 4th, 6th, 8th, 10th, 12th week post CCl4 injection. The regression group underwent black-blood T1rho imaging at the end of the 4th, 6th week post CCl4 injection and the end of 1st, 2nd, 4th, 6th week post CCl4 withdrawal (the injection was stopped at the end of the 6th week). The control group was injected with the same amount of corn oil at the same time point and underwent black-blood T1rho imaging at the end of 4th, 6th, 8th, 10th, 12th week. The liver T1rho values were measured in each group over time. Independent-samples t test was used to analyze the differences of liver T1rho values in adjacent time points. The experimental mice were divided into no liver fibrosis group (S0), mild liver fibrosis group (S1, 2) and moderate or severe liver fibrosis group (S3, 4). The differences of liver T1rho values were analyzed in different fibrosis stages by Kruskal-Wallis H test. The receiver operating characteristic (ROC) curve analysis was used to evaluate the diagnostic ability of T1rho values in staging liver fibrosis. The correlation between liver T1rho values and fibrosis stages was analyzed using Spearman correlation coefficient. Results Fifty-nine rats completed the whole experiment, including 28 rats in the CCl4 group, 20 rats in the recovery group and 11 rats in the control group. In the CCl4 group, the liver T1rho values gradually increased, reached the maximum at the end of week 8, and then gradually decreased. There was statistically significance in liver T1rho values at the adjacent time points (P 0.05) in control group. The T1rho values in the no liver fibrosis group (S0, n=15), the mild liver fibrosis group (S1, 2, n=23) and the moderate or severe liver fibrosis group (S3, 4, n=21) were [36.3(34.4,41.4)], (47.2±8.4), (48.8±9.0) ms, respectively. The liver T1rho values increased with the aggravation of the liver fibrosis, and there was a low positive correlation between them (r=0.402, P=0.001). There were statistically significant differences in T1rho values among the three groups (P<0.01).The area under the curve values to distinguish no liver fibrosis (S0) from liver fibrosis (S1 to 4) and no or mild liver fibrosis (S0 to 2) from moderately or severe liver fibrosis (S3,4) were 0.825 (95% confidence intervals is 0.720 to 0.931) and 0.668 (95% confidence intervals is 0.540 to 0.796), separa
{"title":"The value of MR T1rho for assessing the evolution and severity of liver fibrosis in carbon tetrachloride model rats","authors":"Hanxiong Qi, Shuangshuang Xie, Qing Li, KC Rajendra, Mingzhu Bao, Quan-sheng Zhang, W. Shen","doi":"10.3760/CMA.J.ISSN.1005-1201.2020.03.013","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1005-1201.2020.03.013","url":null,"abstract":"Objective \u0000To investigate the changes of liver spin-lattice relaxation time (T1rho) values in the rotating frame in the progression and regression of carbon tetrachloride (CCl4)-induced model rats with liver fibrosis and the diagnostic values for staging liver fibrosis. \u0000 \u0000 \u0000Methods \u0000Eighty rats were prospectively enrolled and randomly divided into the CCl4 group (n=49), the regression group (n=20) and the control group (n=11). All rats were labeled and then examined using MRI at baseline. The liver fibrosis model was established by subcutaneous injection of 40% CCl4 in hackles. The CCl4 group underwent black-blood T1rho imaging at the end of the 4th, 6th, 8th, 10th, 12th week post CCl4 injection. The regression group underwent black-blood T1rho imaging at the end of the 4th, 6th week post CCl4 injection and the end of 1st, 2nd, 4th, 6th week post CCl4 withdrawal (the injection was stopped at the end of the 6th week). The control group was injected with the same amount of corn oil at the same time point and underwent black-blood T1rho imaging at the end of 4th, 6th, 8th, 10th, 12th week. The liver T1rho values were measured in each group over time. Independent-samples t test was used to analyze the differences of liver T1rho values in adjacent time points. The experimental mice were divided into no liver fibrosis group (S0), mild liver fibrosis group (S1, 2) and moderate or severe liver fibrosis group (S3, 4). The differences of liver T1rho values were analyzed in different fibrosis stages by Kruskal-Wallis H test. The receiver operating characteristic (ROC) curve analysis was used to evaluate the diagnostic ability of T1rho values in staging liver fibrosis. The correlation between liver T1rho values and fibrosis stages was analyzed using Spearman correlation coefficient. \u0000 \u0000 \u0000Results \u0000Fifty-nine rats completed the whole experiment, including 28 rats in the CCl4 group, 20 rats in the recovery group and 11 rats in the control group. In the CCl4 group, the liver T1rho values gradually increased, reached the maximum at the end of week 8, and then gradually decreased. There was statistically significance in liver T1rho values at the adjacent time points (P 0.05) in control group. The T1rho values in the no liver fibrosis group (S0, n=15), the mild liver fibrosis group (S1, 2, n=23) and the moderate or severe liver fibrosis group (S3, 4, n=21) were [36.3(34.4,41.4)], (47.2±8.4), (48.8±9.0) ms, respectively. The liver T1rho values increased with the aggravation of the liver fibrosis, and there was a low positive correlation between them (r=0.402, P=0.001). There were statistically significant differences in T1rho values among the three groups (P<0.01).The area under the curve values to distinguish no liver fibrosis (S0) from liver fibrosis (S1 to 4) and no or mild liver fibrosis (S0 to 2) from moderately or severe liver fibrosis (S3,4) were 0.825 (95% confidence intervals is 0.720 to 0.931) and 0.668 (95% confidence intervals is 0.540 to 0.796), separa","PeriodicalId":39377,"journal":{"name":"Zhonghua fang she xue za zhi Chinese journal of radiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44454568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Autoimmune encephalitis (AE) is a group of non infectious central nervous system autoimmune diseases mainly mediated by cellular and/or humoral immunity, closely related to its anti neural cell antibodies. AE often has a severe clinical course and rapid progression. Early diagnosis and timely immunotherapy are crucial for clinical outcomes, and the vast majority of patients have a good prognosis. The clinical manifestations, laboratory examinations, and imaging features of different types of AE have their corresponding characteristics. The author summarizes the imaging features and differential diagnosis of AE in order to further enhance the understanding of the disease among physicians.
{"title":"Diagnostic imaging and differential diagnosis of autoimmune encephalitis","authors":"Yayun Xiang, Chun-ying Zeng","doi":"10.3760/CMA.J.ISSN.1005-1201.2020.03.018","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1005-1201.2020.03.018","url":null,"abstract":"自身免疫性脑炎（AE）是一组主要由细胞免疫和（或）体液免疫介导的非感染性中枢神经系统自身免疫性疾病，与其抗神经细胞抗体密切相关。AE往往临床病程严重、进展迅速，早期诊断并及时行免疫综合治疗对临床转归至关重要，绝大多数患者预后良好。不同类型AE的临床表现、实验室检查及影像学特征有其相应的特点。笔者对AE的影像学特征及其鉴别诊断进行归纳总结，以期进一步提高广大医师对该病的认识。","PeriodicalId":39377,"journal":{"name":"Zhonghua fang she xue za zhi Chinese journal of radiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45018478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ankle joint excessive exercise injury is a common lower limb injury, including bone injury, osteochondral injury, joint impact syndrome, and tendon and ligament injuries. The early symptoms of the above-mentioned injuries are not obvious, and the correct selection of imaging examination methods is an important link in early detection of injuries, assessment of injury severity, and guidance for treatment. The author discusses the imaging characteristics and injury classification of common ankle joint excessive movement injuries based on typical image images.
{"title":"Imaging in the assessment of overuse injuries in the ankle","authors":"W. Yao","doi":"10.3760/CMA.J.ISSN.1005-1201.2020.03.019","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1005-1201.2020.03.019","url":null,"abstract":"踝关节过度运动损伤是常见的下肢损伤，包括骨损伤、骨软骨损伤、关节撞击综合征及肌腱、韧带损伤。上述损伤早期症状不明显，正确选择影像检查方法是早期发现损伤、评估损伤程度及指导治疗的重要环节。笔者结合典型影像图片对常见踝关节过度运动损伤的影像特点及损伤分型进行论述。","PeriodicalId":39377,"journal":{"name":"Zhonghua fang she xue za zhi Chinese journal of radiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47186962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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