Polski Merkuriusz Lekarski最新文献

Objective: . Aim: The aim of this ambispective, two-center, observational study was to evaluate the clinical characteristics and 3-years prognosis of patients with non-STelevation myocardial infarction (NSTEMI) and AF.

Patients and methods: Materials and methods: Patients hospitalized with a diagnosis of NSTEMI were included. Baseline demographic and clinical features, in-hospital procedures, and occurrence of cardiovascular events in patients with sinus rhythm (SR) and AF confirmed before admission were analyzed.

Results: Results: A total of 273 patients with NSTEMI were enrolled between 2012 and 2015, of whom 102 had AF (37.3%, 60.8% men) and 171 had SR (64.3% men). Patients with AF and NSTEMI were significantly older: 76.6±8.4 vs. 65.9±11.1 years (p<0.0001). The permanent pattern of AF was observed in 54 patients (52.9%) and paroxysmal in 48 patients (47.1%). They more often had heart failure with higher NYHA class (p<0.0001), type 2 diabetes (p=0.0001), abnormal renal function (p<0.0001), and history of stroke (p<0.0001). The presence of AF was not correlated with the number of stenotic coronary vessels. Significantly more NSTEMI patients with AF had a pacemaker implanted before admission (p<0.0001). Duration of hospital stay of NSTEMI AF patients was longer: 10.5±9.9 vs.6.6±4.2 days and it was related to age, Rho=0.5,p=0.0002. During the 2-year and 3-year follow-ups, AF was significantly related to higher mortality, both cardiovascular disease and all-cause mortality (p<0.0001). Independent long-term all-cause mortality predictors were heart failure, liver insufficiency, and age. At the 3-years follow-up, there were no significant differences in all-cause and cardiovascular mortality between groups with permanent AF and paroxysmal AF (p=0.696).

Conclusion: Conclusions: Patients with atrial fibrillation and NSTEMI were older and more likely to have comorbidities. During the 2-year and 3-year follow-ups, AF was related significantly to higher mortality, both cardiovascular and of all causes. The long-term prognosis of patients with AF was adversely affected by heart failure, liver insufficiency and age.

Objective: Aim: Assessment of the risk of soil and groundwater contamination by triazine herbicides to reduce anthropogenic environment pollution and decrease the potential negative impact on public health in Ukraine and the EU.

Patients and methods: Materials and Methods: 14 preparations containing 5 active substances of the triazine class and its environmental fate in soil and water considering Ukraine and EU climatic conditions. Methods of in-field hygienic experiment, gas-liquid chromatography, analytical and statistical methods, hygienic modelling using Experimental Leaching Index (ELI), (GUS), (RLPI), (LIX), (DT50) and (KOC), SCI-GROW, LEACHmod.

Results: Results: Analysis of the physicochemical properties of studied substances showed that they were classified as mobile or moderately mobile by migration ability. Calculated T50 for studied substances allowed us to determine the hazard classes for them. Substances pertain to 2-3 classes (promethrin and terbuthylazine - class 2, moderately persistent (30-100 days), tribenuron-methyl, thifensulfuron-methyl and metribuzin - class 3, weak persistency (less than 30 days)). The determination coefficient (R2) values ranged from 0.704 to 0.995.

Conclusion: Conclusions: According to the GUS, most of the studied substances have a moderate possibility of leaching into groundwater, except for thifensulfuron-methyl. While in EU soils the index for promethrin is very low, tribenuron-methyl is low, terbuthylazine and metribuzin are moderate, and thifensulfuron-methyl is high. The SCI-GROW assessment showed that most of them have significantly lower values in Ukraine than international values (except for promethrin), which can be explained by significant dissimilarities in maximum application rates, number of treatments, and in some cases - different resistance of substances in Ukrainian and EU soils.

Objective: Aim: To evaluate clinical applicability of immune mediator's interleukin-16, immunoglobulin E along with eosinophil count in diagnosing COVID-19 and determining its severity.

Patients and methods: Materials and Methods: Cross-sectional case-control study was conducted at Al-Najaf General Hospital, Najaf, Iraq between March and August 2024. 120 participants: 60 confirmed COVID-19 cases and 60 healthy controls which matched cases in terms of age and sex. Data collected through direct interviews and hospital records; laboratory investigations were performed following standard protocols. Serum analysis: Serum levels of IgE and IL-16 were determined using an automated system and enzyme-linked immune sorbent assay (ELISA).

Results: Results: A significant difference in levels of immune markers between COVID-19 group and healthy controls. Eosinophil count significantly higher in patients than in controls (105±64 cells/ml vs. 78±22 cells/ml, P<0.001). IgE levels in patients were markedly elevated compared to controls (788±98 UI/ml vs. 204±122 UI/ml, P<0.001). IL-16 levels in patients were double of controls (12.8±3.9 pg/ml vs. 6.2±2.9 pg/ml, P<0.01). Logistic regression analysis indicated that elevated levels of IL-16, IgE, and eosinophils were significantly associated with an increased risk of severe COVID-19, with IL-16 showing a particularly strong association (odds ratio=1.7, P<0.001). Sensitivity values were 0.74, 0.48, and 0.85 for eosinophils, IgE, and IL-16, while specificity values were 0.66, 0.58, and 0.72.

Conclusion: Conclusions: Findings underscore probable implication of immune mediators in respect, more especially IL-6, as biomarkers for COVID-19 severity and diagnosis.

The amniotic membrane, which lacks blood vessels, lymphatic vessels and nerves, is a thin membrane with anti-inflammatory and anti-scarring properties. In the field of dentistry, it is primarily employed as a dressing following the removal of malignant or pre-malignant lesions, with the objective of ensuring haemostasis and the absence of allergic reactions. Furthermore, it is employed in the treatment of oro-auricular junctions, cleft palates and in guided bone regeneration, due to the presence of mesenchymal cells. In vestibuloplasty, it has been demonstrated to enhance vestibular deepening, accelerate epithelialisation and reduce pain. In periodontics, it has been shown to be an effective treatment for gingival recession and furcation defects, and to increase the width of keratinised gingiva around implants. In endodontics, it is employed in regenerative procedures, offering comparable results to standard methods. Furthermore, in the treatment of osteoarthritis of the temporomandibular joint, it has been observed to provide pain relief and improved joint function.

Objective: Aim: To study the complexing ability of pectins obtained from various vegetable and fruit raw materials with metal ions.

Patients and methods: Materials and Methods: The content of metals was determined by the atomic emission method (SHIMADZU ICPE-9820 spectrometer); heavy metal measurement methods used were MІ.С3.7.2.01-017 and MІ.С3.7.2.01-018. Statistical analysis of the obtained data was performed using the IBM SPSS Statistics version 29.0.0.0 program; correlation analysis was conducted using the Kendall Tau-b method.

Results: Results: It was found that the highest complexing ability towards the mixture of Cu2+, Zn2+, Cd2+, and Pb2+ ions was demonstrated by low-esterified sugar beet pectin (r=0,600; p<0.01). Citrus (r=0,312; p<0.01), quince (r=0,292; p<0.01), and apple (r=0,271; p<0.01) pectins also exhibited high complexing rates, while pumpkin (r=0,214; p<0.01) and carrot (r=0,156; p<0.01) pectins had slightly lower rates. In addition, pectin is found in smaller quantities in carrots and pumpkins than in sugar beet, citrus fruits, quince, and apples. To improve nutritional characteristics, reduce allergenicity, and maintain high complexing ability of the final product, the authors proposed a combination of raw materials from sugar beet and pumpkin, enriched with apple pectin and/or pectincontaining products and juices of pumpkin and apples.

Conclusion: Conclusions: It was established that the highest complexing ability in relation to a mixture of lead, cadmium, mercury, zinc, and copper ions is possessed by low-esterified sugar beet pectin. The addition of this pectin to apple pectin and/or pectin-containing apple products and juices increases the potential nonspecific detoxification properties of the final food product.

Objective: Aim: To assess the emotional and pain experiences of Ukrainian healthcare workers during the war to identify key targets for multidisciplinary prevention approaches.

Patients and methods: Materials and Methods: The pilot study enrolled 99 healthcare professionals (69 women, 30 men), aged 23-65 years. Participants included doctors (n=69), nurses, and physical therapists (n=30), with experience ranging from under 10 to over 25 years. A 49-item questionnaire was distributed via Google Forms. The survey assessed demographics, workload, emotional stress, pain, and attitudes toward working under wartime conditions. The variables were ranked using categorical and numerical discrete scales, and the data were analyzed using Spearman's rank correlation.

Results: Results: Emotional exhaustion was reported by nearly half of the healthcare professionals at least 2-3 times per week, and pain syndrome was common, particularly lower back pain. Emotional exhaustion showed positive correlations with job dissatisfaction, workload, anxiety, and apathy. Higher pain intensity was linked to decreased productivity and emotional strain, including depression. The impact of war correlated with emotional and physical disruption, yet professionals remained empathetic toward patients. War-induced insomnia was associated with a higher desire to leave the profession, highlighting the longterm risks to healthcare workforce sustainability.

Conclusion: Conclusions: The pilot study highlights the urgent need for preventive multidisciplinary interventions to address emotional strain and pain among healthcare workers. Tailored support strategies may enhance well-being and professional sustainability in high-stress environments.

A case of a 40-year-old patient who presented to the clinic due to carpal tunnel syndrome of the left hand was presented. Four years earlier, the same patient underwent four-finger amputation of his right dominant hand due to fulminant necrosis caused by Streptococcus pyogenes infection. Descriptive history and the results of examination indicated that the patient adapted very good to significant disability of the hand. He had no constant pain, but only when the weather changed, which he rated at 3-4 points on the Numeric Rank Scale. The hand function examined by the DASH questionnaire showed a significant impairment - 42 points, but the patient declared that he functioned well in everyday life and even found a permanent job in a security company.

Objective: Aim: To study the effects of short duration vitamin E supplementation (100 mg/day) on reproductive hormones disturbance estrogen, follicle stimulating hormone, luteinizing hormone, and prolactin.

Patients and methods: Materials and Methods: The study included 40 women with ages ranged between 18-35 years; they were treated from infertility at Al-Zahraa Teaching Hospital in Al-Najaf City in Iraq between June 2023 and May 2024. Women participated in the study were divided into two groups: Group (A): was given vitamin E supplementation (100 mg/day) starting at the 4th day of menstruation; Group (B): was given vitamin E supplementation (100 mg/day) starting at the mid of menstruation (expected ovulation time). The hormonal measurements for (Follicle Stimulating Hormone, Luteinizing Hormone, estradiol and prolactin) were conducted by immunoassay (Cobas E 411).

Results: Results: The results revealed that there was a significant increase in blood level of E after treatment compared to their levels before treatment. The results also indicated that the levels of estradiol and Luteinizing Hormone have been elevated after intervention as compared to that before intervention.

Conclusion: Conclusions: It was concluded the complementation of vitamin E supplementation (100 mg/day) has a positive impact in the enhancement of female hormonal indicators (especially estradiol and Luteinizing Hormone) which may increase the efficiency of the therapeutic approaches of infertility. Early-cycle supplementation also resulted in higher estradiol (P=0.04) and luteinizing hormone levels (P=0.02) compared with mid-cycle supplementation, indicating increased hormonal activity.

Objective: Aim: To detect anti-measles viruses IgG and IgM antibodies using rapid test Cassette and enzyme-linked immunosorbent assay (ELISA).

Patients and methods: Materials and Methods: From October 2024 to December 2024, 352 blood samples obtained from female individuals, including 176 women who had abortions and 176 women with normal pregnancies. IgG and IgM samples were detected using the Cassette and ELISA methods.

Results: Results: Recent measles virus infections, as indicated by rapid IgM test results, showed no significant difference between the abortion group and the control group p=0.248. Additionally, past infections, confirmed by rapid IgG tests, were not significantly different between the patient group and the control group p=0.135. Overall, there was no significant difference in measles virus IgM and IgG levels between the abortion and control groups p>0.05.

Conclusion: Conclusions: The level of education showed significant impact on abortion. Age, residency, and occupation do not affect the risk of abortion, while a low level of education is a significant risk factor for abortion. MV, there was no significant difference in the levels of IgM and IgG between the abortion group and the control group.

The application of magnetic resonance imaging (MRI) techniques in diagnosing posttraumatic stress disorder (PTSD) represents a significant research focus, providing deeper insights into trauma-related psychological disorders. PTSD often arises from chronic stress, a state in which the body struggles to adapt to overwhelming stimuli. Patients frequently experience persistent flashbacks (intrusive memories or sensory recollections of the traumatic event) and nightmares, which evoke intense emotional responses and disrupt daily life. These recurring episodes of stress and anxiety severely impact behavior and functioning. Understanding the brain changes associated with PTSD has become possible through advancements in MRI studies. This article aims to review the scientific literature on the use of magnetic resonance imaging techniques in diagnosing posttraumatic stress disorder. The review is based on scientific literature from medical databases, including Web of Science and Scopus, covering publications up to October 30, 2024. The findings from this analysis may contribute to a better understanding of the neurobiological mechanisms underlying PTSD.