Annals of the ICRP最新文献

Epigenetic regulation plays substantial roles in human pathophysiology, which provides opportunities for intervention in human disorders through the targeting of epigenetic pathways. Recently, emerging evidence from preclinical studies suggested the potential in developing therapeutics of Alzheimer's disease (AD) by targeting bromodomain containing protein 4 (BRD4), an epigenetic regulatory protein. However, further characterization of AD-related pathological events is urgently required. Here, we investigated the effects of pharmacological degradation or inhibition of BRD4 on AD cell models. Interestingly, we found that both degradation and inhibition of BRD4 by ARV-825 and JQ1, respectively, robustly increased the levels of amyloid-beta (Aβ), which has been associated with the neuropathology of AD. Subsequently, we characterized the mechanisms by which downregulation of BRD4 increases Aβ levels. We found that both degradation and inhibition of BRD4 increased the levels of BACE1, the enzyme responsible for cleavage of the amyloid-beta protein precursor (APP) to generate Aβ. Consistent with Aβ increase, we also found that downregulation of BRD4 increased AD-related phosphorylated Tau (pTau) protein in our 3D-AD human neural cell culture model. Therefore, our results suggest that downregulation of BRD4 would not be a viable strategy for AD intervention. Collectively, our study not only shows that BRD4 is a novel epigenetic component that regulates BACE1 and Aβ levels, but also provides novel and translational insights into the targeting of BRD4 for potential clinical applications.

Since the accident at Fukushima Daiichi nuclear power plant, there has been a focus on the impact of low-dose radiation exposure due to nuclear disasters and radiology on human bodies. In order to study very low levels of impact on the human body from low-dose radiation exposure, a system with high detection sensitivity is needed. Until now, the most well-established biological radiation effect detection system in the field of emergency radiation medicine has been chromosomal analysis. However, chromosomal analysis requires advanced skills, and it is necessary to perform chromosomal analysis of a large number of cells in order to detect slight effects on the human body due to low-dose radiation exposure. Therefore, in order to study the effects of low-dose radiation exposure on the human body, it is necessary to develop high-throughput chromosome analysis technology. We have established the PNA-FISH method, which is a fluorescence in-situ hybridisation method using a PNA probe, as a high-throughput chromosome analysis technique. Using this method, the detection of dicentrics and ring chromosomes has become very efficient. Using this technology, chromosomal analysis was performed on peripheral blood before and after computed tomography (CT) examination of patients at Hiroshima University Hospital, and it was possible to detect chromosomal abnormalities due to low-dose radiation exposure in the CT examination. Furthermore, it was shown that there may be individual differences in the increase in chromosomal abnormalities due to low-dose radiation exposure, suggesting the need to build a next-generation medical radiation exposure management system based on individual differences in radiation sensitivity. If techniques such as chromosomal analysis, which have been used for biological dose evaluation in emergency radiation medicine, can be used for general radiology, such as radiodiagnosis and treatment, that will be a contribution to radiology from an unprecedented angle. This article will discuss the clinical application of new biological dose evaluation methods that have been developed in the field of emergency radiation medicine.

Due to vigorous efforts to decontaminate the environment following the accident at Fukushima Daiichi nuclear power plant, the size of the difficult-to-return zone has reduced significantly and people have started returning to their homes. As the population has increased, medical needs have ensued. A marked increase in traffic as well as decontamination and reconstruction projects has led to an increase in the number of road traffic and occupational accidents. Acceleration of population aging has resulted in an increased number of elderly residents with multiple medical problems. Uncontrolled/untreated medical problems among middle-aged to older workers have made them susceptible to deterioration of health conditions. Insufficient social support for elderly people living alone has resulted in delayed access to medical care. Early intervention and the prevention of health deterioration are instrumental. When responding to medical needs, proactive approaches, including home visits for elderly patients and health promotion, have been implemented. Human resource development is crucial to ensure the sustainability of these activities.

As the decommissioning of Fukushima Daiichi nuclear power plant (NPP) progresses, the issue of how to deal with tritiated water has been attracting attention, both domestically and internationally. This article summarises the live discussion at the International Symposium on Tritiated Water, which was held by the Japan Health Physics Society (JHPS) in June 2020. Two issues - the scientific safety of tritiated water and social consensus building - were covered in the live discussion. The importance of further disclosure and dissemination of information based on steady monitoring was highlighted. It was also pointed out that scientific knowledge and scientific research data are merely the bottom line to achieve social consensus. Through the discussions, it was recognised that the role of JHPS is not only to look at the technical issues of safety, but also to look at social issues from the point of view of radiation protection, and to support the solution of these issues.

This paper does not necessarily reflect the views of the International Commission on Radiological Protection.It is known that remediation activities in areas affected by radiological accidents may result in generation of huge volumes of very low-level radioactive waste that can overwhelm national capabilities, and be outside of the existing national regulation requirements for radioactive waste management. This may pose a challenge for adoption of an adequate strategy for remediation waste management and application of regulatory requirements that are commensurate with the waste hazard. The Republic of Belarus faced this problem after the Chernobyl accident when performing remediation activities in the contaminated areas. This article presents the experience of the Republic of Belarus in overcoming the challenges and conflicts that arose in the process of developing a rational strategy for safety management of remediation waste, and its justification and optimisation, bearing in mind the need to adopt advanced regulatory instruments of relevance to the management of this waste.