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Nitrogen-Phosphorus-Potassium containing liquid fertilizer intoxication presenting with extreme hyperkalemia, metabolic acidosis and ECG changes. 氮磷钾液体肥料中毒表现为极度高钾血症、代谢性酸中毒和心电图改变。
Q3 Medicine Pub Date : 2023-01-01
H Rendering, J Westerink, D Dekker, D W De Lange, Kah Kaasjager

Liquid fertilizers are widely used for fertilizing in- and outdoor vegetation. Despite the easy accessibility and widespread use, serious intoxications are rare. This case report describes a 61-year-old woman who was treated for life-threatening hyperkalemia, metabolic acidosis and ECG changes after intentional ingestion of liquid fertilizer. Our case shows that intake of liquid fertilizer, though infrequent, can cause serious, life threatening complications.

液体肥料广泛用于室内和室外植被的施肥。尽管容易获得和广泛使用,但严重的醉酒现象很少发生。本病例报告描述了一名61岁的女性,她因故意摄入液体肥料后出现危及生命的高钾血症、代谢性酸中毒和心电图变化而接受治疗。我们的案例表明,液体肥料的摄入虽然不常见,但会导致严重的、危及生命的并发症。
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引用次数: 0
Outcomes for Emergency Department Final Diagnosis of Non-specific Complaint compared to Dyspnoea and Pain. 急诊科非特异性主诉最终诊断结果与呼吸困难和疼痛的比较。
Q3 Medicine Pub Date : 2023-01-01
R Conway, D Byrne, D O'Riordan, B Silke

Aim: To compare outcomes in Emergency Department (ED) final diagnoses of (non-specific complaint) NSC, dyspnoea and pain.

Methods: We studied all ED final diagnoses of NSC, dyspnoea, and pain over 6 years (2015-2020). Multivariable logistic regression was performed.

Results: There were 49,965 admissions. 30-day in-hospital mortality was significantly lower for pain, 3.0% (95%CI 2.4%, 3.6%), compared to NSC, 4.2% (95%CI 3.8%, 4.7%), and dyspnoea, 4.6% (95%CI 4.2%, 5.0%). NSC did not predict 30-day in-hospital mortality- univariate OR 1.05 (95%CI 0.93, 1.19), multivariable OR 1.07 (95%CI 0.93, 1.23). Comorbidity and Acute Illness Severity Scores demonstrated a curvilinear relationship with 30-day in-hospital mortality.

Conclusion: An ED final diagnosis of NSC did not predict 30-day in-hospital mortality.

目的:比较急诊科(ED)最终诊断为(非特异性主诉)NSC、呼吸困难和疼痛的结果:我们对 6 年内(2015-2020 年)所有急诊科最终诊断为非特异性主诉、呼吸困难和疼痛的病例进行了研究。结果:共收治 49965 人次:结果:共收治了 49965 例患者。与NSC的4.2%(95%CI为3.8%,4.7%)和呼吸困难的4.6%(95%CI为4.2%,5.0%)相比,疼痛的30天院内死亡率明显较低,为3.0%(95%CI为2.4%,3.6%)。NSC不能预测30天的院内死亡率--单变量OR为1.05(95%CI为0.93,1.19),多变量OR为1.07(95%CI为0.93,1.23)。合并症和急性病严重程度评分与30天院内死亡率呈曲线关系:结论:急诊室最终诊断为NSC并不能预测30天的院内死亡率。
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引用次数: 0
Enhanced Care Units: Guidance on development and implementation within Acute Medicine. 加强护理单位:急性医学发展和实施指南。
Q3 Medicine Pub Date : 2023-01-01 DOI: 10.52964/AMJA.0929
Nicholas Smallwood, Sanjay Krishnamoorthy, Kathleen Bonnici, Tim Wenham, Paul Dean, Sarah Dyson, Hattie Jones, Andrew Walden, Jennie Stephens, Jan Basey, Tash Kelly, Kirsten Evans

The Society for Acute Medicine (SAM) and Intensive Care Society (ICS) have produced joint guidance on the standards of care and infrastructure required to deliver enhanced care within Acute Medicine. The cohort of patients this relates to are in the most part already being looked after on the AMU, but co-location and providing enhanced monitoring and nursing input will ensure safe, high-quality care can be delivered to them. We strongly support the development of enhanced care units, whilst clearly acknowledging that they are not a replacement for critical care where that is indicated. Enhanced care and critical care complement each other and will help foster the close working between the two specialties that modern acute care requires. This guidance draws on expertise and existing relevant guidance from the two societies, alongside that from the Faculty of Intensive Care Medicine (FICM), British Thoracic Society (BTS), National Institute for Health and Care Excellence (NICE) and NHS England / Improvement (NHSE/I). We recognise this is an area with limited evidence and so will aim to review it regularly as the knowledge and experience in this area increases.

急性医学学会(SAM)和重症监护学会(ICS)已经就在急性医学范围内提供加强护理所需的护理标准和基础设施制定了联合指南。与此相关的患者群体大部分已经在AMU得到照顾,但共同安置和提供加强的监测和护理投入将确保向他们提供安全、高质量的护理。我们强烈支持加强护理单位的发展,同时也清楚地认识到,在需要的情况下,它们不能取代重症监护。强化护理和重症护理相辅相成,将有助于促进现代急性护理所需的两个专业之间的密切合作。该指南借鉴了两个学会的专业知识和现有相关指导,以及重症医学系(FICM)、英国胸科学会(BTS)、国家健康与护理卓越研究所(NICE)和英国国民保健服务体系(NHSE/I)的专业知识和相关指导。我们认识到这是一个证据有限的领域,因此随着这一领域知识和经验的增加,我们将定期对其进行审查。
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引用次数: 0
Listeria Meningitis, one of your five a day? A case report of Listeria Monocytogenes Meningitis in a fit and well 62-year-old woman. 李斯特菌脑膜炎,你每天五个人中的一个吗?一例单核细胞增生李斯特菌脑膜炎在一个健康和良好的62岁妇女。
Q3 Medicine Pub Date : 2023-01-01 DOI: 10.52964/AMJA.0942
L Harrington, G Fisk, M Elanchenny, S Shaikh, U Shah

Listeria Monocytogenes is transmitted via ingestion of contaminated food products and can cause invasive disease in susceptible hosts. Risk factors include immunocompromise; pregnancy; being elderly; and new-born. Listeriosis is uncommon but can occur in immunocompetent individuals and has a high mortality rate. We report a case of a 62-year-old female with no obvious risk factors who presented with atypical meningism. The patient was subsequently diagnosed with listeria meningitis and made a good recovery. The patient was a gardener regularly handling soil and ingested vegetables from her allotment patch; this case is reported to highlight less common risk factors and atypical ways in which listeria may present to the acute medical take.

单核细胞增生李斯特菌通过摄入受污染的食品传播,可在易感宿主中引起侵袭性疾病。危险因素包括免疫功能低下;怀孕;老年人;和新生。李斯特菌病不常见,但可发生在免疫能力强的个体,死亡率高。我们报告一例62岁的女性没有明显的危险因素谁提出了不典型脑膜炎。患者随后被诊断为脑膜炎李斯特菌,并恢复良好。患者是一名园丁,经常处理土壤,并从她分配的土地上摄入蔬菜;据报道,该病例突出了不太常见的危险因素和李斯特菌可能出现在急性医疗采取的非典型方式。
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引用次数: 0
Artificial Intelligence: its Future and Impact on Acute Medicine. 人工智能:它的未来及其对急性医学的影响。
Q3 Medicine Pub Date : 2023-01-01
M Schinkel, K Paranjape, S C Bhagirath, Pwb Nanayakkara

This commentary explores the potential impact of artificial intelligence (AI) in acute medicine, considering its possibilities and challenges. With its ability to simulate human intelligence, AI holds the promise for supporting timely decision-making and interventions in acute care. While AI has significantly contributed to improvements in various sectors, its implementation in healthcare remains limited. The development of AI tools tailored to acute medicine can improve clinical decision-making, and AI's role in streamlining administrative tasks, exemplified by ChatGPT, may offer immediate benefits. However, challenges include uniform data collection, privacy, bias, and preserving the doctor-patient relationship. Collaboration among AI researchers, healthcare professionals, and policymakers is crucial to harness the potential of AI in acute medicine and create a future where advanced technologies synergistically enhance human expertise.

这篇评论探讨了人工智能在急性医学中的潜在影响,考虑了它的可能性和挑战。凭借其模拟人类智能的能力,人工智能有望支持急性护理的及时决策和干预。尽管人工智能对各个领域的改善做出了重大贡献,但其在医疗保健领域的实施仍然有限。为急性医学量身定制的人工智能工具的开发可以改善临床决策,而人工智能在简化管理任务方面的作用,例如ChatGPT,可能会带来立竿见影的好处。然而,挑战包括统一的数据收集、隐私、偏见和维护医患关系。人工智能研究人员、医疗保健专业人员和政策制定者之间的合作对于利用人工智能在急性医学中的潜力并创造一个先进技术协同增强人类专业知识的未来至关重要。
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引用次数: 0
Both acuity and long term prognosis are important Emergency Department metrics: comparison of mobility assessment with the Emergency Severity Index. 敏锐度和长期预后都是急诊科的重要指标:行动能力评估与急诊严重程度指数的比较。
Q3 Medicine Pub Date : 2023-01-01
I Arnold, T Kuster, J M Busch, J G Kellett, M Brabrand, R Bingisser, C H Nickel

Objective: To compare the SUHB mobility scale (i.e., stable(S), unstable gait(U), needing help to walk(H), or bedridden(B)) and the Emergency Severity Index (ESI) associations with admission and mortality outcomes.

Design: Post-hoc analysis of a prospective observational study including all consenting presenting to the ED over a period of 3 weeks. Odd ratios and AUCs were calculated to assess predictive performance of SUHB and compared with ESI.

Results: Out of 2422 patients, 65% presented with a stable gait, 45% with an ESI level 3. With increasing mobility impairment on the SUHB scale, the probability for admission and mortality increased. SUHB had a higher AUC than ESI for 1-year mortality.

Conclusion: SUHB was a better predictor than ESI of long-term mortality. The scale, which is rapid, requires little additional training, and no extra costs, could be used as a useful supplement to the triage process.

目的:比较SUHB行动能力量表(即稳定(S)、步态不稳定(U)、需要帮助行走(H)或卧床不起(B))和紧急情况严重程度指数(ESI)与入院和死亡率的关系。设计:前瞻性观察性研究的事后分析,包括在3周内向ED提交的所有同意书。计算比值比和AUC以评估SUHB的预测性能,并与ESI进行比较。结果:在2422名患者中,65%的患者步态稳定,45%的患者ESI水平为3。随着SUHB量表上活动障碍的增加,入院和死亡的概率增加。SUHB的1年死亡率AUC高于ESI。结论:SUHB是一个比ESI更好的预测长期死亡率的指标。这种规模很快,几乎不需要额外的培训,也不需要额外费用,可以作为分诊过程的有用补充。
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引用次数: 0
Antimicrobial neurotoxicity: an under-recognised cause of delirium. 抗菌神经毒性:谵妄的一个未被认识的原因。
Q3 Medicine Pub Date : 2022-04-01 DOI: 10.52964/AMJA.0908
D. Moynan, E. Maqbool, E. de Barra
Antimicrobial associated encephalopathy (AAE) is a well-documented, though under recognised, adverse event associated with antimicrobial use. Clinical manifestations of AAE are varied, ranging from myoclonus and seizure to an encephalopathy with cerebellar signs. The phenotypic presentation of the encephalopathy syndrome is, in general, governed by the antimicrobial in question. Given its apparent rarity in everyday clinical practice, awareness of AAE is crucial for physicians. We describe a reversible encephalopathy characterised by confusion, myoclonus and stupor in a 76 year old gentleman on antimicrobial therapy for a peri-rectal abscess.
抗菌素相关脑病(AAE)是一种有据可查但未得到充分认识的与抗菌素使用相关的不良事件。AAE的临床表现多种多样,从肌阵挛和癫痫发作到伴有小脑体征的脑病。一般来说,脑病综合征的表型表现是由所讨论的抗菌素控制的。鉴于其在日常临床实践中明显罕见,对AAE的认识对医生至关重要。我们描述了一个可逆性脑病的特点是混乱,肌阵挛和麻木在一个76岁的绅士抗菌治疗直肠周围脓肿。
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引用次数: 0
Developing priorities for quality improvement in acute medicine using a modified Delphi method A consensus process hosted by the Society for Acute Medicine Quality Improvement Committee (SAM-QI). 使用改进的德尔菲方法制定急性医学质量改进的优先事项——由急性医学质量改善委员会(SAM-QI)主持的共识过程。
Q3 Medicine Pub Date : 2022-04-01 DOI: 10.52964/AMJA.0901
A. Kennedy, M. Holland, P. Sullivan, A. Gebril, N. Arora, V. Vijayakumar, A. Hoole, C. Nickel, C. Hodcroft, L. Harrington, M. Wheble, J. Soong, N. Scriven, J. Kellett, K. Slinger, V. Price, J. Alsma, S. Astbury, R. Varia, A. Rigby, C. Subbe
INTRODUCTIONThe SAM Quality Improvement Committee (SAM-QI), set up in 2016, has worked over the last year to determine the priority Acute Medicine QI topics. They have also discussed and put forward proposals to improve QI training for Acute Medicine professionals.METHODSA modified Delphi process was completed over four rounds to determine priority QI topics. Online meetings were also used to develop proposals for QI training.RESULTSSame Day Emergency Care (SDEC) was chosen as the priority topic for QI work within Acute Medicine.CONCLUSIONThe SAM-QI group settled on SDEC being the priority topic for Acute Medicine QI development. Throughout the Delphi process SAM-QI has also developed proposals for QI training that will help Acute Medicine professionals deliver coordinated meaningful improvements in care.
简介SAM质量改进委员会(SAM-QI)成立于2016年,在过去一年中一直致力于确定急性医学QI的优先主题。他们还讨论并提出了改进急性医学专业人员QI培训的建议。方法对德尔菲过程进行了四轮改进,以确定优先QI主题。在线会议也被用来制定QI培训的建议。结果选择日间急救(SDEC)作为急性医学QI工作的优先主题。结论SAM-QI小组确定SDEC是急性医学QI发展的优先课题。在整个德尔菲过程中,SAM-QI还制定了QI培训建议,帮助急性医学专业人员在护理方面提供协调一致的有意义的改进。
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引用次数: 0
Isolated paracetamol-induced acute kidney injury: a systematic review. 对乙酰氨基酚引起的急性肾损伤:一项系统综述。
Q3 Medicine Pub Date : 2022-04-01 DOI: 10.52964/AMJA.0904
M. Williams, J. Coulson
AIMWe sought to characterise the syndrome of isolated paracetamol-induced acute kidney injury (AKI), whose incidence and mechanisms are poorly understood.METHODSUsing systematic review methodology, fifty-six papers relating to paracetamol-induced AKI were identified.RESULTS24 cases of isolated paracetamol-induced AKI were identified and compared to 87 identified cases of concurrent renal and hepatic injury. Paracetamol-induced AKI became detectable 3-4 days after exposure; liver injury, where it occurred, preceded AKI detection by 1 day. Risk factors affecting hepatotoxicity risk do not appear to influence isolated AKI, with no clear associated factors except younger age (mean 18.8 versus 33.1 years).CONCLUSIONSIsolated paracetamol-induced AKI appears commoner in younger patients. Paracetamol-induced AKI occurs late and may go undetected by current treatment guidelines.
目的我们试图描述单独的扑热息痛诱导的急性肾损伤(AKI)的综合征,其发病率和机制尚不清楚。方法采用系统综述的方法,对56篇与扑热息痛诱导的AKI相关的论文进行了鉴定。结果24例分离的对乙酰氨基酚诱导的AKI病例被鉴定,并与87例已鉴定的并发肾和肝损伤病例进行了比较。对乙酰氨基酚诱导的AKI在暴露3-4天后可检测到;发生肝损伤的地方,在AKI检测之前1天。影响肝毒性风险的危险因素似乎不会影响孤立的AKI,除了年龄较小(平均18.8岁对33.1岁)外,没有明确的相关因素。结论:孤立的对乙酰氨基酚诱导的AKI在年轻患者中更常见。对乙酰氨基酚诱导的AKI发生较晚,目前的治疗指南可能未发现。
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引用次数: 0
The prediction of early mortality by the ROX index of oxygenation and respiratory rate in diverse Canadian and Ugandan cohorts of unselected patient: a post-hoc retrospective analysis of 80,558 patient observations. 通过氧合和呼吸速率的ROX指数预测加拿大和乌干达不同队列中未选择患者的早期死亡率:对80558名患者观察结果的事后回顾性分析。
Q3 Medicine Pub Date : 2022-04-01 DOI: 10.52964/AMJA.0900
J. Kellett, F. Sikakulya, C. Nickel
AIMTo investigate the association between in-hospital mortality and the ROX index of respiratory rate and oxygenation in diverse cohorts of unselected patient at different prediction windows.METHODSA retrospective post-hoc analysis of data from a major regional referral Canadian hospital and a low-resource hospital in sub-Saharan Africa.RESULTSFour patient cohorts were examined: Canadian medical, surgical and intensive care unit (ICU) patients, and all patients admitted to an African hospital. In all patients in-hospital mortality rose as ROX declined. Apart from ICU patients, ROX had a high discrimination for death within 72 hours. For non-ICU patients the negative predictive value of death within 72 hours for a ROX value <22 ranged from 0.994 to 1.000 Conclusion: In diverse cohorts of unselected patients, the ROX index has a high discrimination for death within 72 hours. However, the index has little or no prognostic value for patient admitted to ICU.
目的探讨不同预测窗期未入选患者不同队列的住院死亡率与呼吸频率和氧合ROX指数的相关性。方法回顾性分析来自加拿大一家主要区域转诊医院和撒哈拉以南非洲一家资源匮乏医院的数据。结果对四组患者进行了检查:加拿大内科、外科和重症监护病房(ICU)患者,以及非洲一家医院的所有患者。在所有患者中,住院死亡率随着ROX的下降而上升。除ICU患者外,ROX对72小时内死亡的歧视程度较高。对于非icu患者,ROX值<22对72小时内死亡的阴性预测值在0.994 ~ 1.000之间。结论:在不同的非入选患者队列中,ROX指数对72小时内死亡具有较高的判别性。然而,该指数对ICU住院患者的预后价值很小或没有价值。
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引用次数: 2
期刊
Acute Medicine
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