Nano-Structures & Nano-Objects最新文献_第2页

Hydromagnetic micropolar nanofluid heat and mass transfer in a porous channel with thermophoresis, brownian motion and non-uniform heat source

IF 5.45 Q1 Physics and Astronomy

Nano-Structures & Nano-Objects

Pub Date : 2025-02-01 DOI: 10.1016/j.nanoso.2025.101456

E.O. Fatunmbi, O.L. Aako

Understanding heat and mass transfer in the flow dynamics of nanofluids within a porous channel has significant applications in various engineering fields, such as groundwater remediation in environmental engineering, enhanced oil recovery in petroleum engineering, and heat exchanger design in system cooling engineering, among others. In light of these applications, the current research focuses on the hydromagnetic flow and heat transfer mechanisms of a non-Newtonian micropolar nanofluid through a porous channel. A mathematical model incorporating the influence of a magnetic field, thermal radiative flux, temperature-dependent thermal conductivity, and a non-uniform heat source is developed with engineered colloidal nanoparticles using the Buongiorno model. The model is transformed into an ordinary differential equation from the initial partial differential equations using appropriate transformations. The resulting model is solved numerically to obtain the solution for the transport phenomena. Several tables are compiled, and graphs are plotted to illustrate the influence of key parameters with real engineering relevance. The investigation revealed that the skin friction coefficient significantly decreased due to the micropolar fluid parameter, while the vortex viscosity term amplified the couple stress profile. Furthermore, the systems thermal energy increased with higher thermophoresis, Brownian motion, and Peclet numbers for heat and mass diffusion. In contrast, the hydrodynamic boundary layer thickness decreased as the strength of the porosity and magnetic field terms increased.

{"title":"Hydromagnetic micropolar nanofluid heat and mass transfer in a porous channel with thermophoresis, brownian motion and non-uniform heat source","authors":"E.O. Fatunmbi, O.L. Aako","doi":"10.1016/j.nanoso.2025.101456","DOIUrl":"10.1016/j.nanoso.2025.101456","url":null,"abstract":"<div><div>Understanding heat and mass transfer in the flow dynamics of nanofluids within a porous channel has significant applications in various engineering fields, such as groundwater remediation in environmental engineering, enhanced oil recovery in petroleum engineering, and heat exchanger design in system cooling engineering, among others. In light of these applications, the current research focuses on the hydromagnetic flow and heat transfer mechanisms of a non-Newtonian micropolar nanofluid through a porous channel. A mathematical model incorporating the influence of a magnetic field, thermal radiative flux, temperature-dependent thermal conductivity, and a non-uniform heat source is developed with engineered colloidal nanoparticles using the Buongiorno model. The model is transformed into an ordinary differential equation from the initial partial differential equations using appropriate transformations. The resulting model is solved numerically to obtain the solution for the transport phenomena. Several tables are compiled, and graphs are plotted to illustrate the influence of key parameters with real engineering relevance. The investigation revealed that the skin friction coefficient significantly decreased due to the micropolar fluid parameter, while the vortex viscosity term amplified the couple stress profile. Furthermore, the systems thermal energy increased with higher thermophoresis, Brownian motion, and Peclet numbers for heat and mass diffusion. In contrast, the hydrodynamic boundary layer thickness decreased as the strength of the porosity and magnetic field terms increased.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"41 ","pages":"Article 101456"},"PeriodicalIF":5.45,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143512558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A fixed-bed-column study on arsenic removal from water using an in situ-synthesized nanocomposite of magnetite and reduced graphene oxide

IF 5.45 Q1 Physics and Astronomy

Nano-Structures & Nano-Objects

Pub Date : 2025-02-01 DOI: 10.1016/j.nanoso.2025.101431

Maria R. Galstenkova , Yulia R. Mukhortova , Artyom S. Pryadko , Vladimir V. Botvin , Dmitry V. Wagner , Anna A. Sharonova , Maria A. Surmeneva , Roman A. Surmenev

This study presents in situ synthesis of a nanocomposite of Fe₃O₄ nanoparticles directly grown on the surface of two-dimensional (2D) reduced-graphene-oxide nanosheets. The morphology, structure, chemical and phase composition, and magnetic properties of the developed nanocomposite were investigated. The nanocomposite, when mixed with sand, effectively addressed the challenge of arsenic removal from water on a fixed-bed column with sorption capacity 8.40 and 8.96 mg/g for arsenic concentrations 0.1 and 10 mg/L, respectively. This performance is superior to that reported in the literature for alternative iron-containing arsenic sorbents. The sorption isotherms were modelled using the Thomas model and the R-square value was around 0.9, reflecting good correlation between the experimental data and isotherm model. The As³⁺ sorption process caused no significant changes in structure, phase composition, and magnetic properties of the nanocomposite, implying its good potential for reuse and its economic viability for applications related to arsenic removal from contaminated water.

{"title":"A fixed-bed-column study on arsenic removal from water using an in situ-synthesized nanocomposite of magnetite and reduced graphene oxide","authors":"Maria R. Galstenkova , Yulia R. Mukhortova , Artyom S. Pryadko , Vladimir V. Botvin , Dmitry V. Wagner , Anna A. Sharonova , Maria A. Surmeneva , Roman A. Surmenev","doi":"10.1016/j.nanoso.2025.101431","DOIUrl":"10.1016/j.nanoso.2025.101431","url":null,"abstract":"<div><div>This study presents <em>in situ</em> synthesis of a nanocomposite of Fe<sub>3</sub>O<sub>4</sub> nanoparticles directly grown on the surface of two-dimensional (2D) reduced-graphene-oxide nanosheets. The morphology, structure, chemical and phase composition, and magnetic properties of the developed nanocomposite were investigated. The nanocomposite, when mixed with sand, effectively addressed the challenge of arsenic removal from water on a fixed-bed column with sorption capacity 8.40 and 8.96 mg/g for arsenic concentrations 0.1 and 10 mg/L, respectively. This performance is superior to that reported in the literature for alternative iron-containing arsenic sorbents. The sorption isotherms were modelled using the Thomas model and the R-square value was around 0.9, reflecting good correlation between the experimental data and isotherm model. The As<sup>3</sup><sup>+</sup> sorption process caused no significant changes in structure, phase composition, and magnetic properties of the nanocomposite, implying its good potential for reuse and its economic viability for applications related to arsenic removal from contaminated water.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"41 ","pages":"Article 101431"},"PeriodicalIF":5.45,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143100423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polymer/POSS based robust and emerging flame retardant nanocomposites: A comprehensive review

IF 5.45 Q1 Physics and Astronomy

Nano-Structures & Nano-Objects

Pub Date : 2025-02-01 DOI: 10.1016/j.nanoso.2024.101427

Ayesha Sattar , Shahzar Hafeez , Mateen Hedar , Muhammad Saeed , Tajamal Hussain , Azeem Intisar

Synthetic polymers are extensively utilized in electronics, automobiles, building materials and numerous other commercial items where different types of flame retardants are employed to develop safety among these polymers. Higher safety requirements include efficient flame-retardancy, great persistence, low release of heat, smoke and toxic gases and no considerable change in the overall properties of these polymers. Polyhedral oligomeric silsesquioxane (POSS) are three dimensional architectures that can be effectively introduced in almost all existing polymers to attain desired properties. This review focuses on their thermal, mechanical and flame retardant characteristics with commonly used polymer/POSS nanocomposites using epoxy resins, cellulose, silicone rubber, polyamide, polyimide, polyurethanes, polypropylene etc. owing to their remarkable structural and functional characteristics i.e., thermal stability, low toxicity, environmental neutrality and biocompatibility. The goal of this study is to provide an overview of the most significant and state-of-the-art developments in polymer/POSS nanocomposites and their variants. Owing to their great potential towards fire retardancy and excellent physical properties, various robust materials have been mentioned and critically discussed. General properties, methods of preparation, mechanism and modes of action of polymer / POSS nanocomposites have also been presented. Furthermore, challenges and possible future prospects have also been discussed.

{"title":"Polymer/POSS based robust and emerging flame retardant nanocomposites: A comprehensive review","authors":"Ayesha Sattar , Shahzar Hafeez , Mateen Hedar , Muhammad Saeed , Tajamal Hussain , Azeem Intisar","doi":"10.1016/j.nanoso.2024.101427","DOIUrl":"10.1016/j.nanoso.2024.101427","url":null,"abstract":"<div><div>Synthetic polymers are extensively utilized in electronics, automobiles, building materials and numerous other commercial items where different types of flame retardants are employed to develop safety among these polymers. Higher safety requirements include efficient flame-retardancy, great persistence, low release of heat, smoke and toxic gases and no considerable change in the overall properties of these polymers. Polyhedral oligomeric silsesquioxane (POSS) are three dimensional architectures that can be effectively introduced in almost all existing polymers to attain desired properties. This review focuses on their thermal, mechanical and flame retardant characteristics with commonly used polymer/POSS nanocomposites using epoxy resins, cellulose, silicone rubber, polyamide, polyimide, polyurethanes, polypropylene etc. owing to their remarkable structural and functional characteristics i.e., thermal stability, low toxicity, environmental neutrality and biocompatibility. The goal of this study is to provide an overview of the most significant and state-of-the-art developments in polymer/POSS nanocomposites and their variants. Owing to their great potential towards fire retardancy and excellent physical properties, various robust materials have been mentioned and critically discussed. General properties, methods of preparation, mechanism and modes of action of polymer / POSS nanocomposites have also been presented. Furthermore, challenges and possible future prospects have also been discussed.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"41 ","pages":"Article 101427"},"PeriodicalIF":5.45,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Larvicidal effects of biofabricated iron nanoparticles made from the aqueous extracts of Eupatorium adenophorum and Artocarpus hirsutus, with their effect on the predatory efficiency of mosquito fish

IF 5.45 Q1 Physics and Astronomy

Nano-Structures & Nano-Objects

Pub Date : 2025-02-01 DOI: 10.1016/j.nanoso.2024.101430

C.T. Sunila , V.P. Sylas , Neethu Cyril , Raisa Kabeer , Jerry Mechery , B.N. Anila , Smitha Knox

The present study investigated the larvicidal effect of bio-synthesized iron nanoparticles (FeNPs) using two tropical plant species, Artocarpus hirsutus and Eupatorium adenophorum against Culex quinquefasciatus mosquito larvae. The synthesized nanoparticles, AH-FeNP and EA-FeNP were characterized by UV–vis spectroscopy, XRD analysis, AFM, HR-TEM, and EDX. Preliminary phytochemical studies and FTIR confirmed the presence of secondary metabolites with hydroxyl, amine, and carbonyl as reducing/ capping agents. Results of the characterization indicated that the plant-mediated Fe-NPs have the size of 29–36 nm and had high crystalline nature. As synthesized nanoparticles have shown considerable larvicidal activity against C. quinquefasciatus with LC₅₀ and LC₉₀ values of 3.316 mg/L and 6.558 mg/L for AH-FeNP, 3.296 mg/L and 7.529 mg/L for EA-FeNP respectively. Furthermore, the result revealed that both FeNPs have distinct concentration-dependent larval mortality. They were toxic at higher concentrations (35 mg/L) and showed 76.66 % mortality of mosquito larvae for AH-FeNP and 73 % for EA-FeNP. The in-situ experiment with both FeNPs and their effect on the mosquito fish Gambusia affinis have shown an improved efficiency of predation and the fishes have no ill effects after being susceptible to both FeNPs for a week. Overall, the result depicts that both AH-FeNP and EA-FeNP have mosquito larvicidal activity especially against larvae of C. quinquefasciatus and the in-vitro exposure study showed that they are less toxic to fishes like G.affinis. The present work also suggests bioaugmented iron nanoparticles can be contemplated as a futuristic, efficacious and environmentally safe pesticide.

{"title":"Larvicidal effects of biofabricated iron nanoparticles made from the aqueous extracts of Eupatorium adenophorum and Artocarpus hirsutus, with their effect on the predatory efficiency of mosquito fish","authors":"C.T. Sunila , V.P. Sylas , Neethu Cyril , Raisa Kabeer , Jerry Mechery , B.N. Anila , Smitha Knox","doi":"10.1016/j.nanoso.2024.101430","DOIUrl":"10.1016/j.nanoso.2024.101430","url":null,"abstract":"<div><div>The present study investigated the larvicidal effect of bio-synthesized iron nanoparticles (FeNPs) using two tropical plant species, <em>Artocarpus hirsutus</em> and <em>Eupatorium adenophorum</em> against <em>Culex quinquefasciatus</em> mosquito larvae. The synthesized nanoparticles, AH-FeNP and EA-FeNP were characterized by UV–vis spectroscopy, XRD analysis, AFM, HR-TEM, and EDX. Preliminary phytochemical studies and FTIR confirmed the presence of secondary metabolites with hydroxyl, amine, and carbonyl as reducing/ capping agents. Results of the characterization indicated that the plant-mediated Fe-NPs have the size of 29–36 nm and had high crystalline nature. As synthesized nanoparticles have shown considerable larvicidal activity against <em>C. quinquefasciatus</em> with LC<sub>50</sub> and LC<sub>90</sub> values of 3.316 mg/L and 6.558 mg/L for AH-FeNP, 3.296 mg/L and 7.529 mg/L for EA-FeNP respectively. Furthermore, the result revealed that both FeNPs have distinct concentration-dependent larval mortality. They were toxic at higher concentrations (35 mg/L) and showed 76.66 % mortality of mosquito larvae for AH-FeNP and 73 % for EA-FeNP. The in-situ experiment with both FeNPs and their effect on the mosquito fish <em>Gambusia affinis</em> have shown an improved efficiency of predation and the fishes have no ill effects after being susceptible to both FeNPs for a week. Overall, the result depicts that both AH-FeNP and EA-FeNP have mosquito larvicidal activity especially against larvae of <em>C. quinquefasciatus</em> and the in-vitro exposure study showed that they are less toxic to fishes like <em>G.affinis.</em> The present work also suggests bioaugmented iron nanoparticles can be contemplated as a futuristic, efficacious and environmentally safe pesticide.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"41 ","pages":"Article 101430"},"PeriodicalIF":5.45,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Charge-specific and hesperidin loaded mesoporous silica nanoparticles: Enhanced antimicrobial activity against pathogenic bacteria

IF 5.45 Q1 Physics and Astronomy

Nano-Structures & Nano-Objects

Pub Date : 2025-02-01 DOI: 10.1016/j.nanoso.2025.101441

Divya Sree H.R., Satyanarayana Swamy Vyshnava, Muralidhara Rao Dowlathabad

This study successfully synthesized and evaluated mesoporous silica nanoparticles (MSNs) for charge-based antimicrobial delivery systems. The presence and development of MSN particles were verified by UV-Visible spectroscopy, which exhibited distinct peaks that corresponded with prior research. The MSNs, which were examined using HR-TEM (high-resolution transmission electron microscopy) and FE-SEM (field emission scanning electron microscopy), had a spherical shape with an average diameter of 65.0 ± 2.0 nm. They were found to be amorphous, as confirmed by XRD (X-ray diffraction) and SAED (selected area electron diffraction) patterns. The presence of amino, carboxyl, and PEG groups on the surface was confirmed by FTIR, suggesting that the modification was successful. The modified MSNs exhibited differences in hydrodynamic size and surface charge, as evidenced by dynamic light scattering (DLS) and zeta potential tests. The most efficient loading of hesperidin (Hes) was attained when the ratio of MSN to Hes was 1:10, as determined by UV-Visible spectra. The MSN-Hesperidin with a positive charge displayed the most potent antibacterial action against E. coli and Pseudomonas aeruginosa. It showed greater effectiveness compared to MSNs with a negative charge, MSNs with no charge, and free Hesperidin. The improved antibacterial efficacy can be ascribed to the efficient interaction between positively charged MSNs and bacterial cell membranes, along with the regulated release characteristics of the MSNs.

{"title":"Charge-specific and hesperidin loaded mesoporous silica nanoparticles: Enhanced antimicrobial activity against pathogenic bacteria","authors":"Divya Sree H.R., Satyanarayana Swamy Vyshnava, Muralidhara Rao Dowlathabad","doi":"10.1016/j.nanoso.2025.101441","DOIUrl":"10.1016/j.nanoso.2025.101441","url":null,"abstract":"<div><div>This study successfully synthesized and evaluated mesoporous silica nanoparticles (MSNs) for charge-based antimicrobial delivery systems. The presence and development of MSN particles were verified by UV-Visible spectroscopy, which exhibited distinct peaks that corresponded with prior research. The MSNs, which were examined using HR-TEM (high-resolution transmission electron microscopy) and FE-SEM (field emission scanning electron microscopy), had a spherical shape with an average diameter of 65.0 ± 2.0 nm. They were found to be amorphous, as confirmed by XRD (X-ray diffraction) and SAED (selected area electron diffraction) patterns. The presence of amino, carboxyl, and PEG groups on the surface was confirmed by FTIR, suggesting that the modification was successful. The modified MSNs exhibited differences in hydrodynamic size and surface charge, as evidenced by dynamic light scattering (DLS) and zeta potential tests. The most efficient loading of hesperidin (Hes) was attained when the ratio of MSN to Hes was 1:10, as determined by UV-Visible spectra. The MSN-Hesperidin with a positive charge displayed the most potent antibacterial action against E. coli and Pseudomonas aeruginosa. It showed greater effectiveness compared to MSNs with a negative charge, MSNs with no charge, and free Hesperidin. The improved antibacterial efficacy can be ascribed to the efficient interaction between positively charged MSNs and bacterial cell membranes, along with the regulated release characteristics of the MSNs.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"41 ","pages":"Article 101441"},"PeriodicalIF":5.45,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Confined selenium chains in one-dimensional mordenite nanochannels: A TEM and Raman spectroscopy study

IF 5.45 Q1 Physics and Astronomy

Nano-Structures & Nano-Objects

Pub Date : 2025-02-01 DOI: 10.1016/j.nanoso.2025.101448

Edgar Mosquera-Vargas , Mario A. Millan-Franco , Carlos Marín

This study investigates the incorporation of selenium chains into the nanochannels of hydrated mordenite (MOR) using high-resolution TEM imaging, Raman spectroscopy, and computational simulations. The results reveal that selenium chains are successfully incorporated within the mordenite framework, with changes in image contrast confirming its presence. Raman spectroscopy was employed to identify the selenium species in Se-MOR, revealing characteristic vibrational modes associated with trigonal selenium structures. Raman spectrum for Se-MOR displayed peaks at 250 cm^–1, attributed to symmetric bond-stretching, and at 265 cm^–1, linked to antisymmetric bond-stretching, confirming the presence of selenium chains within the nanochannels of the mordenite structure. Crystallographic modeling and TEM analysis show that these selenium chains are integrated into specific nanochannels, influencing the Se-MOR growth directions. TEM imaging and SimulaTEM simulations at 300 and 400 keV in bright field mode show no changes in pure mordenite but reveal darker regions in Se-MOR corresponding to selenium chains. STEM_CELL simulations in dark field mode confirm increased intensity in selenium-rich regions, consistent with conventional TEM mode observation. Comparisons between simulated and experimental Raman spectrum show good agreement, suggesting that selenium chains primarily occupy small nanochannels in hydrated mordenite, while larger nanochannels in dehydrated mordenite may accommodate a range of selenium species. Additionally, the study explores the impact of water molecules on selenium incorporation, showing that only selenium chains are formed in the small channels in the presence of water.

{"title":"Confined selenium chains in one-dimensional mordenite nanochannels: A TEM and Raman spectroscopy study","authors":"Edgar Mosquera-Vargas , Mario A. Millan-Franco , Carlos Marín","doi":"10.1016/j.nanoso.2025.101448","DOIUrl":"10.1016/j.nanoso.2025.101448","url":null,"abstract":"<div><div>This study investigates the incorporation of selenium chains into the nanochannels of hydrated mordenite (MOR) using high-resolution TEM imaging, Raman spectroscopy, and computational simulations. The results reveal that selenium chains are successfully incorporated within the mordenite framework, with changes in image contrast confirming its presence. Raman spectroscopy was employed to identify the selenium species in Se-MOR, revealing characteristic vibrational modes associated with trigonal selenium structures. Raman spectrum for Se-MOR displayed peaks at 250 cm<sup>–1</sup>, attributed to symmetric bond-stretching, and at 265 cm<sup>–1</sup>, linked to antisymmetric bond-stretching, confirming the presence of selenium chains within the nanochannels of the mordenite structure. Crystallographic modeling and TEM analysis show that these selenium chains are integrated into specific nanochannels, influencing the Se-MOR growth directions. TEM imaging and SimulaTEM simulations at 300 and 400 keV in bright field mode show no changes in pure mordenite but reveal darker regions in Se-MOR corresponding to selenium chains. STEM_CELL simulations in dark field mode confirm increased intensity in selenium-rich regions, consistent with conventional TEM mode observation. Comparisons between simulated and experimental Raman spectrum show good agreement, suggesting that selenium chains primarily occupy small nanochannels in hydrated mordenite, while larger nanochannels in dehydrated mordenite may accommodate a range of selenium species. Additionally, the study explores the impact of water molecules on selenium incorporation, showing that only selenium chains are formed in the small channels in the presence of water.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"41 ","pages":"Article 101448"},"PeriodicalIF":5.45,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143437766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Colloidal formulations of etoposide based on self-assembling oleyl-hyaluronan-based structures: Optimization of technology and in vitro analysis

IF 5.45 Q1 Physics and Astronomy

Nano-Structures & Nano-Objects

Pub Date : 2025-02-01 DOI: 10.1016/j.nanoso.2025.101443

M.M. Antonova , S.Sh. Karshieva , A.A. Nikitin , Yu.A. Malinovskaya , D.V. Ermolin , A.S. Novikov , E.V. Skorb , D.V. Beigulenko , T.S. Kovshova , E.A. Kalacheva , A.A. Filin , S.E. Gelperina , Yu.V. Ermolenko

The ability of the conjugate of hyaluronic acid and oleic acid (oleyl hyaluronan — HA-C18:1) to form self-assembling micellar structures was utilized to enhance the water solubility of the anticancer drug etoposide (ETP) and its prodrug, 4-O′-benzyloxycarbonyl derivative (ETP-Cbz). Using density functional theory (DFT), it was established that the ETP-Cbz associate with HA-C18:1 had greater thermodynamic stability compared to the ETP associate, which was confirmed experimentally. The micelles loaded with ETP-Cbz were smaller (268 nm compared to 407 nm), more stable (with the critical micelle concentration (CMC) decreasing from 0.07 to 0.025 mg/mL), and had the higher drug loading efficiency (82 %) as compared to HA-C18:1/ETP micelles. In vitro experiments showed that both micellar formulations exhibited low hemolytic activity and delayed drug release profiles during the first hours. In vitro cytotoxicity against MCF-7 and MDA-MB-231 cell lines showed the dose-dependent decrease in cell viability whereas the toxic effect against normal human dermal fibroblasts (NHDF) was significantly lower and exceeded the concentration of HA-C18:1 in the micellar formulations. Confocal microscopy was used to confirm the active uptake of micellar formulations by MDA-MB-231 cells. These findings, therefore, suggest that HA-C18:1 may be a promising solubilizing agent for etoposide and its prodrug.

{"title":"Colloidal formulations of etoposide based on self-assembling oleyl-hyaluronan-based structures: Optimization of technology and in vitro analysis","authors":"M.M. Antonova , S.Sh. Karshieva , A.A. Nikitin , Yu.A. Malinovskaya , D.V. Ermolin , A.S. Novikov , E.V. Skorb , D.V. Beigulenko , T.S. Kovshova , E.A. Kalacheva , A.A. Filin , S.E. Gelperina , Yu.V. Ermolenko","doi":"10.1016/j.nanoso.2025.101443","DOIUrl":"10.1016/j.nanoso.2025.101443","url":null,"abstract":"<div><div>The ability of the conjugate of hyaluronic acid and oleic acid (oleyl hyaluronan — HA-C18:1) to form self-assembling micellar structures was utilized to enhance the water solubility of the anticancer drug etoposide (ETP) and its prodrug, 4-O′-benzyloxycarbonyl derivative (ETP-Cbz). Using density functional theory (DFT), it was established that the ETP-Cbz associate with HA-C18:1 had greater thermodynamic stability compared to the ETP associate, which was confirmed experimentally. The micelles loaded with ETP-Cbz were smaller (268 nm compared to 407 nm), more stable (with the critical micelle concentration (CMC) decreasing from 0.07 to 0.025 mg/mL), and had the higher drug loading efficiency (82 %) as compared to HA-C18:1/ETP micelles. In vitro experiments showed that both micellar formulations exhibited low hemolytic activity and delayed drug release profiles during the first hours. In vitro cytotoxicity against MCF-7 and MDA-MB-231 cell lines showed the dose-dependent decrease in cell viability whereas the toxic effect against normal human dermal fibroblasts (NHDF) was significantly lower and exceeded the concentration of HA-C18:1 in the micellar formulations. Confocal microscopy was used to confirm the active uptake of micellar formulations by MDA-MB-231 cells. These findings, therefore, suggest that HA-C18:1 may be a promising solubilizing agent for etoposide and its prodrug.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"41 ","pages":"Article 101443"},"PeriodicalIF":5.45,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143100515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphological change of ZnO using hydrothermal technique and organic modifiers

IF 5.45 Q1 Physics and Astronomy

Nano-Structures & Nano-Objects

Pub Date : 2025-02-01 DOI: 10.1016/j.nanoso.2025.101436

Md. Kawcher Alam , Md. Sahadat Hossain , Mofassel Hossen Akash , Abdullah Al Miad , Muhammad Shahriar Bashar , Newaz Mohammed Bahadur , Samina Ahmed

This study provides the findings of a novel synthesis of zinc oxide (ZnO) nanoparticles by hydrothermal method. ZnO nanoparticles were synthesized using different organic solvents such as ethylene glycol (EG) and citric acid (CA) as a reaction medium. Utilizing X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), and Fourier transform infrared (FT-IR) spectroscopy, the formed nanoflower and nanosphere zinc oxide were characterized. The studies' findings showed that the solvents controlled the dimension and morphology of the formed nanoparticles. X-ray diffraction (XRD) confirmed the formation of the ZnO, and the crystallite size (Scherrer method) of the produced nanoflowers and nanospheres was found to be 46.18 nm and 31.72 nm, respectively. It was evident from the peak of the FT-IR spectrum between 432 and 551 cm^-1 that the ZnO phase is contained in the produced nanoparticles. Using Rietveld refinement analysis, it has been found that the ZnO phase is almost 100 % pure.

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引用次数: 0

TiO2 nanotubes as an efficient green catalyst for the multi-component synthesis of blue light emissive pyrazolyl-thaizole based fluorophores

IF 5.45 Q1 Physics and Astronomy

Nano-Structures & Nano-Objects

Pub Date : 2025-02-01 DOI: 10.1016/j.nanoso.2025.101439

Sultana Shaik , Sai Teja Talari , Rama Mohana Reddy Sirigireddy , Pushpavathi Itte , Kakarla Raghava Reddy , Chinna Gangi Reddy Nallagondu , Tejraj M. Aminabhavi

TiO₂ nanotubes (TNTs) are employed as a green heterogeneous catalyst for the synthesis of solid-state blue light emissive pyrazolyl-thiazoles (PZTZs) (4) via the three-component reaction of β-enaminones (1), thiosemicarbazide (2) and α-bromoketones (3) in ethanol and water (2:1). TNTs were prepared by hydrothermal method and characterized by XRD, UV-Vis DRS, photoluminescence (PL), HRTEM and EDAX techniques. Construction of three C–N and one C-S bonds in a single-step, nature-friendly reaction profile, large substrate scope, use of non-hazardous solvents, excellent yields (91–98 %) in short reaction times, gram scale feasibility and formation of pure products without the help of column purification are the attractive features of the present multi-component reaction (MCR) strategy. In addition, the catalytic medium displayed excellent efficiency towards diversified β-enaminones (1) and α-bromoketones (3); the recovered TNTs catalyst is used 7 times. Photophysical and electrochemical properties of PZTZs (4) have been investigated. The synthesized PZTZs (4) showed tunable photophysical and electrochemical properties by varying the substituents on both thiazole and pyrazole rings. Hence, the PZTZs (4) are promising materials for fabricating efficient and economically viable blue organic light-emitting diodes (BOLEDs).

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引用次数: 0

Review on titanium oxide (TiO2) nanomaterials in multidomain investigations 多领域研究中的氧化钛 (TiO2) 纳米材料综述

IF 5.45 Q1 Physics and Astronomy

Nano-Structures & Nano-Objects

Pub Date : 2025-02-01 DOI: 10.1016/j.nanoso.2025.101455

Shivani , Ramesh S. Bhat , AG Bindu , Shyama Prasad Sajankila

The unique properties of titanium led to the rigorous research of its nanoscale composite and alloy derivatives in biomedicine and photocatalysis. Despite this, more refinement is necessary in the surface modification of titanium nanomaterials (NMs) for the advancement of property and to reduce detrimental responses. A synthetic strategy for titanium NMs is planned in physical, chemical, and biochemical routes to accomplish desired properties and targeted implementation. Titanium oxide is studied as zero-dimensional, higher-dimensional, and different polymorphs. The structural and surface analysis is evaluated by several advanced techniques. Nanotechnology aims to produce titanium materials with nanoscale dimensions, modified surfaces, chemical stability, scalability, and high mechanical strength. Thus, it can act as the best candidate for multimode research. However, the invaluable number of literature summaries focused on the genotoxicity, bio-accumulation, and ecotoxicity resulting after prolonged implementation of the titanium oxide NMs, this can be combated with surface manipulation ability provided by the nanomaterial through the decoration of the surface with inorganic and organic moieties which enhanced the overall efficiency of the material. The current review is focused on the synthesis of TiO₂ NMs, structural evaluations, toxicity, surface modification, and its implementations in the field of medicine, material development, and pollution control, including industrial applications such as cosmetics, food safety, and energy storage. Hence defining the titanium nanomaterial as a versatile material for multidomain research.

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引用次数: 0