Changwen Jing, H. Cao, Jianzhong Wu, Rong Ma, Junying Zhang, Siwen Liu, Zhuo Wang
To gain an insight into the molecular mechanisms of gefitinib resistance in nonsmall cell lung cancer, we screened out the long noncoding RNA related to gefitinib resistance through microarray data in gefitinib‐sensitive and resistant cells. lncRNA ZMIZ1‐AS1 was significantly upregulated in HCC827/GR cells by screening the microarray data. Further real‐time‐qPCR results were consistent with the microarray data. Cell viability assay and flow cytometry showed that ZMIZ1‐AS1 influenced the sensitivity of HCC827/GR cells to gefitinib. RNA pull‐down assay demonstrated that hnRNPA1 was a specific binding protein for ZMIZ1‐AS1. Our results help to reveal the role and mechanism of lncRNA in the secondary resistance of gefitinib and provide a new therapeutic target for gefitinib therapy.
{"title":"Long noncoding RNA ZMIZ1‐AS1 promotes gefitinib resistance via binding to hnRNPA1","authors":"Changwen Jing, H. Cao, Jianzhong Wu, Rong Ma, Junying Zhang, Siwen Liu, Zhuo Wang","doi":"10.1002/prm2.12051","DOIUrl":"https://doi.org/10.1002/prm2.12051","url":null,"abstract":"To gain an insight into the molecular mechanisms of gefitinib resistance in nonsmall cell lung cancer, we screened out the long noncoding RNA related to gefitinib resistance through microarray data in gefitinib‐sensitive and resistant cells. lncRNA ZMIZ1‐AS1 was significantly upregulated in HCC827/GR cells by screening the microarray data. Further real‐time‐qPCR results were consistent with the microarray data. Cell viability assay and flow cytometry showed that ZMIZ1‐AS1 influenced the sensitivity of HCC827/GR cells to gefitinib. RNA pull‐down assay demonstrated that hnRNPA1 was a specific binding protein for ZMIZ1‐AS1. Our results help to reveal the role and mechanism of lncRNA in the secondary resistance of gefitinib and provide a new therapeutic target for gefitinib therapy.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"10 1","pages":"133 - 137"},"PeriodicalIF":0.5,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/prm2.12051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48573888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ping Zhang, Yun-xia Zhao, Bo Yang, Bing Wu, Lei Gu
To explore the effect of rehabilitation‐oriented nursing intervention on self‐care ability and social relationship quality of patients with esophageal cancer after operation. 124 esophageal cancer patients from February 2019 to January 2020 were selected and divided into study group and control group. The control group was given routine nursing, and the study group was given rehabilitation‐oriented nursing intervention on the basis of the control group. The self‐care ability score (ESCA), social relationship quality score (SQRS), mood state score, hope level score (HHI), and nursing job satisfaction were statistically analyzed. Before intervention, there was no significant difference between two groups. After intervention, the scores of health knowledge, self‐concept, self‐responsibility, and self‐care skills were higher in the study group. The scores of friend relationship, family commitment, and family intimacy were significantly higher in the study group, also the SAS (Self‐Rating Anxiety Scale) and SDS (Self‐Rating Depression Scale) scores in the study group were lower than those in the control group, and the scores of attitudes to maintain close relationship with others, attitude to take positive action and attitude towards reality and future in the study group were higher than those in the control group. In addition, the satisfaction of nursing work in the study group was higher than that in the control group. The rehabilitation needs oriented nursing intervention for esophageal cancer patients can effectively regulate patients' depression and anxiety, improve their self‐care ability and hope level, improve the quality of social relations, and patients have high recognition of nursing work.
{"title":"The effect of nursing intervention guided by rehabilitation needs on the quality of postoperative self‐care agency and social relationships in esophageal cancer patients","authors":"Ping Zhang, Yun-xia Zhao, Bo Yang, Bing Wu, Lei Gu","doi":"10.1002/prm2.12050","DOIUrl":"https://doi.org/10.1002/prm2.12050","url":null,"abstract":"To explore the effect of rehabilitation‐oriented nursing intervention on self‐care ability and social relationship quality of patients with esophageal cancer after operation. 124 esophageal cancer patients from February 2019 to January 2020 were selected and divided into study group and control group. The control group was given routine nursing, and the study group was given rehabilitation‐oriented nursing intervention on the basis of the control group. The self‐care ability score (ESCA), social relationship quality score (SQRS), mood state score, hope level score (HHI), and nursing job satisfaction were statistically analyzed. Before intervention, there was no significant difference between two groups. After intervention, the scores of health knowledge, self‐concept, self‐responsibility, and self‐care skills were higher in the study group. The scores of friend relationship, family commitment, and family intimacy were significantly higher in the study group, also the SAS (Self‐Rating Anxiety Scale) and SDS (Self‐Rating Depression Scale) scores in the study group were lower than those in the control group, and the scores of attitudes to maintain close relationship with others, attitude to take positive action and attitude towards reality and future in the study group were higher than those in the control group. In addition, the satisfaction of nursing work in the study group was higher than that in the control group. The rehabilitation needs oriented nursing intervention for esophageal cancer patients can effectively regulate patients' depression and anxiety, improve their self‐care ability and hope level, improve the quality of social relations, and patients have high recognition of nursing work.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"10 1","pages":"127 - 132"},"PeriodicalIF":0.5,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46499584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Changwen Jing, H. Cao, Rong Ma, Jianzhong Wu, Zhuo Wang
Recently, mutation profiles provided new insights into comprehensive understanding of TC biology by Next Generation Sequencing (NGS). We explored association between mutation profiles and clinicopathological features in Chinese patients with thyroid cancer (TC). Two hundred and twenty‐five formalin‐fixed, paraffin‐embedded tissue specimens from surgically removed thyroid samples were detected with 15 target genes by NGS. Mutation profiles and clinicopathological features were analyzed. Two hundred and seven mutations including two hundred mutations in 81.40% papillary thyroid carcinoma samples, three mutations in 50.00% MTC samples, and four mutations in 100% anaplastic thyroid carcinoma samples were detected. There were 19.56% samples without any mutations in target genes, 69.78% samples harbored mutations in single gene, 9.78% samples carried two gene mutations, and 0.89% samples had triple different gene mutations. For PTC, BRAF mutations were predominant, TERT mutations are more prevalent in advanced PTC and RET fusion was only observed among the PTC. For MTC, RET point mutations were predominant. For samples carried more than one gene mutations, the allelic frequency of mutants were almost similar. Multiple mutations in TC patients were significantly more frequent in cases of patients aged 55 and over (p <.001) and advanced American Joint Committee on Cancer (AJCC) cancer stage (p <.001). Gender (p = .309) and pathological subtype (p = .121) did not show significant correlation with mutations. Analysis between mutation profiles and clinicopathological features provides new insights into the biology of TC and is expected to increase the accuracy of diagnosis and prognostication in TC, leading to improved precision treatment for TC patients.
{"title":"Association between mutation profiles and clinicopathological features in Chinese patients with thyroid cancer","authors":"Changwen Jing, H. Cao, Rong Ma, Jianzhong Wu, Zhuo Wang","doi":"10.1002/prm2.12048","DOIUrl":"https://doi.org/10.1002/prm2.12048","url":null,"abstract":"Recently, mutation profiles provided new insights into comprehensive understanding of TC biology by Next Generation Sequencing (NGS). We explored association between mutation profiles and clinicopathological features in Chinese patients with thyroid cancer (TC). Two hundred and twenty‐five formalin‐fixed, paraffin‐embedded tissue specimens from surgically removed thyroid samples were detected with 15 target genes by NGS. Mutation profiles and clinicopathological features were analyzed. Two hundred and seven mutations including two hundred mutations in 81.40% papillary thyroid carcinoma samples, three mutations in 50.00% MTC samples, and four mutations in 100% anaplastic thyroid carcinoma samples were detected. There were 19.56% samples without any mutations in target genes, 69.78% samples harbored mutations in single gene, 9.78% samples carried two gene mutations, and 0.89% samples had triple different gene mutations. For PTC, BRAF mutations were predominant, TERT mutations are more prevalent in advanced PTC and RET fusion was only observed among the PTC. For MTC, RET point mutations were predominant. For samples carried more than one gene mutations, the allelic frequency of mutants were almost similar. Multiple mutations in TC patients were significantly more frequent in cases of patients aged 55 and over (p <.001) and advanced American Joint Committee on Cancer (AJCC) cancer stage (p <.001). Gender (p = .309) and pathological subtype (p = .121) did not show significant correlation with mutations. Analysis between mutation profiles and clinicopathological features provides new insights into the biology of TC and is expected to increase the accuracy of diagnosis and prognostication in TC, leading to improved precision treatment for TC patients.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"10 1","pages":"113 - 117"},"PeriodicalIF":0.5,"publicationDate":"2021-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/prm2.12048","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41887166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We investigated the perceived professional benefit of nurses engaged in internet nursing services of Internet Cooperative Hospitals in Nanjing, China, and explored factors influencing nurse assessment.
{"title":"A critical assessment of factors influencing the perceived professional benefit of internet nurses","authors":"Xiaoxu Li, Yichang Zhu, Bo Yang, Bing Wu, Meixiang Wang, Yun-xia Zhao","doi":"10.1002/prm2.12043","DOIUrl":"https://doi.org/10.1002/prm2.12043","url":null,"abstract":"We investigated the perceived professional benefit of nurses engaged in internet nursing services of Internet Cooperative Hospitals in Nanjing, China, and explored factors influencing nurse assessment.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"10 1","pages":"106 - 112"},"PeriodicalIF":0.5,"publicationDate":"2021-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/prm2.12043","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42152486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Breast cancer is a major threat to human health. For a long term, breast cancer and the side effects of cancer treatments affect health and life quality of cancer survivors. With the development of medical technology for breast cancer in recent decades, the long‐term survival rate of breast cancer patients has been dramatically improved. There is an urgent need to identify and establish a health care model that could provide more customized, long‐term, and comprehensive medical services for breast cancer patients, especially for those in China. Multiple cancer survivorship care plans that have been widely used in Western countries, such as chronic care, shared care, and disease‐specific model, were summarized from original researches, systemic reviews, and health guidelines published by national and international health organizations. In currently available cancer survivorship care plans, oncology nurses played an indispensable significant role. But current existing cancer survivorship care plans could not be directly implemented in China due to different cultural backgrounds between Eastern and Western countries. Some adjustments and modifications need to be done on the basis of existing survivorship care plan to make it more suitable to Chinese patients' needs and with Chinese characteristics. For providing continuous and integrated high‐quality cancer survivorship care suitable for Chinese health care system, innovative technologies (telehealth, internet‐based symptom monitoring, mobile applications, etc.) could be rationally used as supplementary tools for current cancer survivorship care plans.
{"title":"The improvement in continuity and integrity of survivorship care for breast cancer survivors in Chinese healthcare system","authors":"Shuchang Lou, Jun Li, Dejing Xu","doi":"10.1002/prm2.12042","DOIUrl":"https://doi.org/10.1002/prm2.12042","url":null,"abstract":"Breast cancer is a major threat to human health. For a long term, breast cancer and the side effects of cancer treatments affect health and life quality of cancer survivors. With the development of medical technology for breast cancer in recent decades, the long‐term survival rate of breast cancer patients has been dramatically improved. There is an urgent need to identify and establish a health care model that could provide more customized, long‐term, and comprehensive medical services for breast cancer patients, especially for those in China. Multiple cancer survivorship care plans that have been widely used in Western countries, such as chronic care, shared care, and disease‐specific model, were summarized from original researches, systemic reviews, and health guidelines published by national and international health organizations. In currently available cancer survivorship care plans, oncology nurses played an indispensable significant role. But current existing cancer survivorship care plans could not be directly implemented in China due to different cultural backgrounds between Eastern and Western countries. Some adjustments and modifications need to be done on the basis of existing survivorship care plan to make it more suitable to Chinese patients' needs and with Chinese characteristics. For providing continuous and integrated high‐quality cancer survivorship care suitable for Chinese health care system, innovative technologies (telehealth, internet‐based symptom monitoring, mobile applications, etc.) could be rationally used as supplementary tools for current cancer survivorship care plans.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"10 1","pages":"100 - 105"},"PeriodicalIF":0.5,"publicationDate":"2021-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/prm2.12042","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46973835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qingshan Hu, Jian Wang, Weiguo Xu, Peng Shao, Gang Li
The aim of this study is to explore the survival situation of locally advanced gastric cancer (GC) patients with pathological complete response (pCR) following neoadjuvant chemotherapy (NAC).
本研究旨在探讨新辅助化疗（NAC）后病理完全反应（pCR）的局部晚期癌症（GC）患者的生存情况。
{"title":"Survival outcomes of locally advanced gastric cancer cases with pathological complete response received neoadjuvant chemotherapy","authors":"Qingshan Hu, Jian Wang, Weiguo Xu, Peng Shao, Gang Li","doi":"10.1002/prm2.12038","DOIUrl":"https://doi.org/10.1002/prm2.12038","url":null,"abstract":"The aim of this study is to explore the survival situation of locally advanced gastric cancer (GC) patients with pathological complete response (pCR) following neoadjuvant chemotherapy (NAC).","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"10 1","pages":"78 - 82"},"PeriodicalIF":0.5,"publicationDate":"2021-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/prm2.12038","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49589588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Changmin Mao, Jing Cheng, Hong Xia, Jing Li, Jing Zhou, Aifeng Meng, Xiaoxu Zhi, Meixiang Wang
To explore the application and effect of standardized health education pathway in patients undergoing EBUS‐TNBA.
探讨标准化健康教育路径在EBUS-TNBA患者中的应用及效果。
{"title":"Effects of standardized health education pathway on patients undergoing endobronchial ultrasound‐guided transbronchial needle aspiration","authors":"Changmin Mao, Jing Cheng, Hong Xia, Jing Li, Jing Zhou, Aifeng Meng, Xiaoxu Zhi, Meixiang Wang","doi":"10.1002/prm2.12032","DOIUrl":"https://doi.org/10.1002/prm2.12032","url":null,"abstract":"To explore the application and effect of standardized health education pathway in patients undergoing EBUS‐TNBA.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"10 1","pages":"71 - 77"},"PeriodicalIF":0.5,"publicationDate":"2021-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/prm2.12032","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44696021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To investigate the effect of Acapella training on respiratory function in patients undergoing video‐assisted thoracic surgery (VATS).
研究Acapella训练对接受视频辅助胸部手术（VATS）患者呼吸功能的影响。
{"title":"The effect of Acapella trainer on respiratory function of patients after thoracoscopic lung cancer surgery","authors":"Xin-xin Lu, Y. Qiang","doi":"10.1002/prm2.12040","DOIUrl":"https://doi.org/10.1002/prm2.12040","url":null,"abstract":"To investigate the effect of Acapella training on respiratory function in patients undergoing video‐assisted thoracic surgery (VATS).","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"10 1","pages":"86 - 89"},"PeriodicalIF":0.5,"publicationDate":"2021-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/prm2.12040","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46689427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：