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2007 Computers in Cardiology最新文献

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Disorder classification in the regulatory mechanism of the cardiovascular system 心血管系统调节机制中的紊乱分类
Pub Date : 2007-09-01 DOI: 10.1109/CIC.2007.4745529
A. Jalali, A. Ghaffari, M. Ghasemi, H. Sadabadi, P. Ghorbanian, H. Golbayani
An approach to classify disorders in autonomic control of cardiovascular system is proposed in this paper. The target of this study is to highlight main features of malfunctions in cardiovascular system due to autonomic disorder. Collecting the data from the physionet archive, we divide patients into two groups of normal and abnormal, based on having autonomic disorder in their cardiovascular system or not. Systolic blood pressure (SBP) and heart rate (HR) time series are evaluated for each patient. We then plot the diagram of SBP against HR for all patients in a single figure. Fuzzy c-means clustering (FCM) method is also applied to cluster data into two groups. A neural network is then implemented to classify and to distinguish the two groups. The network is trained with data of a normal patient and is tested with data of other normal and abnormal patients. Result show that selected features can clearly detect disorders in autonomic system.
本文提出了一种对心血管系统自主控制疾病进行分类的方法。本研究的目的是强调自主神经障碍引起的心血管系统功能障碍的主要特征。从physionet档案中收集数据,我们根据患者心血管系统是否存在自主神经障碍,将患者分为正常和异常两组。评估每位患者的收缩压(SBP)和心率(HR)时间序列。然后,我们将所有患者的收缩压与HR绘制成一个图。采用模糊c均值聚类(FCM)方法将数据聚为两组。然后利用神经网络对两组进行分类和区分。该网络使用正常患者的数据进行训练,并使用其他正常和异常患者的数据进行测试。结果表明,所选择的特征可以清晰地检测出自主神经系统的紊乱。
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引用次数: 1
Cyclic variation in heart rate during sleep in four recordings of up to 13 years in elderly adults 四份长达13年的老年人睡眠期间心率的循环变化记录
Pub Date : 2007-09-01 DOI: 10.1109/CIC.2007.4745414
P. Stein, R. Cohen, N. Devlin, E.M. Lundequam, P. Domitrovich, J. Gottdiener, S. Redline
To characterize changes in nighttime cyclic variation in HR (CVHR) with advancing age in older adults, CVHR was quantified for N=56 adults with 2 Holter recordings 5 yrs apart (CHS1 and CHS 2) in the cardiovascular health study (CHS) and 2 overnight polysomnograms 5 yrs apart in the sleep heart health study (SHHS1 and SHHS2) using MatLab. Baseline age was 71plusmn3 yrs. The number of CVHR events was also normalized to time in bed (CVHR index). CVHR index did not change across recordings, but males had higher values (p=0.009). Mean HR increase during CVHR was similar in the first 3 recording but declined on the last (p<0.02). CVHR duration increased, but CHS1 vs. CHS2 and SHHS1 vs. SHHS2 were NS (rest, p<0.007). We conclude that CVHR is frequent at night in older adults, but results suggest an age-related trend towards decreased magnitude and longer durations of HR arousals, possibly due to the aging of the autonomic nervous system.
为了描述老年人夜间HR (CVHR)周期变化随年龄增长的变化,我们对56名成年人的CVHR进行了量化,其中包括心血管健康研究(CHS)中间隔5年的2次动态心电图(CHS1和CHS 2)和睡眠心脏健康研究(SHHS1和SHHS2)中间隔5年的2次夜间多路睡眠图(MatLab)。基线年龄71岁+ 3岁。CVHR事件的数量也被归一化到床上时间(CVHR指数)。CVHR指数在不同的记录中没有变化,但男性的值更高(p=0.009)。CVHR期间的平均HR增加在前3次记录中相似,但在最后一次记录中下降(p<0.02)。CVHR持续时间增加,但CHS1 vs CHS2、SHHS1 vs SHHS2为NS(其余,p<0.007)。我们的结论是,CVHR在老年人中经常发生在夜间,但结果表明,与年龄相关的趋势是HR唤醒的强度降低和持续时间延长,可能是由于自主神经系统的衰老。
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引用次数: 0
A multilead approach to T-wave alternans detection combining principal component analysis and the Laplacian likelihood ratio method 结合主成分分析和拉普拉斯似然比法的多导联t波交替检测方法
Pub Date : 2007-09-01 DOI: 10.1109/CIC.2007.4745407
V. Monasterio, J.P. Martinez
Several methods have been proposed to automatically detect and estimate T-wave alternans (TWA) in the ECG, all of them operating on a single-lead basis. In this study a multilead detection scheme is proposed. It combines principal component analysis with the Laplacian likelihood ratio method to improve the detection results. A simulation is carried out to evaluate the effect of different types of simulated and physiological noise, and to assess the performance of this detection scheme. According to simulation results, the proposed multilead approach can detect alternans with a SNR 30 dB lower than the single-lead approach, showing a remarkable improvement of the sensitivity to low-level alternans.
已经提出了几种方法来自动检测和估计心电图中的t波交流(TWA),所有这些方法都是在单导联的基础上工作的。本研究提出了一种多引线检测方案。将主成分分析与拉普拉斯似然比方法相结合,提高了检测结果。通过仿真来评估不同类型的模拟噪声和生理噪声的影响,并评估该检测方案的性能。仿真结果表明,与单引脚方法相比,多引脚方法可以检测到信噪比低30 dB的交流信号,对低电平交流信号的灵敏度有显著提高。
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引用次数: 6
Performance evaluation of 4D reconstruction methods for gated cardiac single photon emission computed tomography in obese patients 肥胖患者门控心脏单光子发射计算机断层扫描4D重建方法的性能评价
Pub Date : 2007-09-01 DOI: 10.1109/CIC.2007.4745499
S. Sayeram, D. Lalush
The purpose of this study is to evaluate 4D reconstruction methods for the processing of gated cardiac single photon emission computed tomography (SPECT) images from obese patients. Clinical gated SPECT projection data were reconstructed using the ordered-sub sets expectation- maximization (OS-EM) and the 4D reseated block- iterative maximum a posteriori (RBI-MAP) reconstruction algorithms. The data were used to derive a relative distribution of quantitative tetrofosmin uptake ratios for the various organs. Using anthropometric data, body sizes were determined for a standard obese male and female NURBS-based cardiac torso (NCAT) phantom. Tetrofosmin uptake ratios were modeled in the obese phantoms and projection data were generated. Poisson noise was simulated, and the noisy data were reconstructed with OS-EM and 4D RBI-MAP. The projected and reconstructed data from the obese phantoms make for a realistic model of tetrofosmin uptake distribution. Qualitatively, 4D processing methods substantially improve visualization of cardiac motion in these very noisy images. We conclude that the tetrofosmin patient models provide a realistic, controllable test vehicle on which to evaluate 4D processing methods for gated cardiac SPECT. 4D processing methods improve the quality of gated SPECT images in obese patients, providing a usable representation of cardiac motion in these difficult-to-image patients.
本研究的目的是评估处理肥胖患者门控心脏单光子发射计算机断层扫描(SPECT)图像的4D重建方法。采用有序子集期望最大化(OS-EM)和四维重定位块迭代最大后验(RBI-MAP)重建算法重建临床门控SPECT投影数据。这些数据被用来推导出不同器官的定量四磷蛋白摄取比率的相对分布。使用人体测量数据,确定标准肥胖男性和女性基于nurbs的心脏躯干(NCAT)幻影的体型。在肥胖幻影中建立了四小龙蛋白摄取比模型,并生成了投影数据。模拟泊松噪声,利用OS-EM和4D RBI-MAP对噪声数据进行重构。从肥胖幻影中预测和重建的数据构成了一个现实的四角磷蛋白摄取分布模型。从质量上讲,4D处理方法大大提高了这些非常嘈杂的图像中心脏运动的可视化。我们认为,四磷蛋白患者模型为评估门控心脏SPECT的4D处理方法提供了一个现实的、可控的试验载体。4D处理方法提高了肥胖患者门控SPECT图像的质量,为这些难以成像的患者提供了可用的心脏运动表征。
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引用次数: 0
Evaluation of auto-regressive modeling procedures for the detection of abnormal intra-QRS potentials using a boundary element electrocardiogram model 评估使用边界元心电图模型检测异常qrs内电位的自回归建模程序
Pub Date : 2007-09-01 DOI: 10.1109/CIC.2007.4745478
M. Svendsen, T. Oostendorp, E. Berbari
Auto-regressive modeling procedures (AR) have been used to quantify low magnitude components of abnormal activation within the QRS complex, called abnormal intra-QRS potentials (AIQPs). Research is still needed to identify the range in which the AR model can detect AIQP sources in different locations in the heart. A ventricular source model and forward model of electrocardiography called ECGSIM was used to test the ability of the AR model in detecting delays at various locations in the ventricles. A high resolution ECGSIM heart model was created to provide greater temporal and spatial control of the AIQP sources. The overall optimal model orders in this study were at an intermediate range seen previously in the literature. The ability of the AR model to detect the AIQP sources was dependent on the resolution of the heart model and the size and location of the AIQP sources.
自回归建模程序(AR)已被用于量化QRS复合体内异常激活的低量级成分,称为异常QRS内电位(AIQPs)。AR模型在心脏不同位置检测AIQP源的范围仍需进一步研究。使用心室源模型和心电图正演模型ECGSIM来测试AR模型检测心室不同位置延迟的能力。建立了一个高分辨率ECGSIM心脏模型,以提供对AIQP源的更大的时空控制。本研究的整体最优模型阶数处于先前文献中所见的中间范围。AR模型检测AIQP源的能力取决于心脏模型的分辨率和AIQP源的大小和位置。
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引用次数: 3
Assessment of myocardial damage in chronic chagasic patients using QRS slopes QRS斜率法评价慢性肝病患者心肌损害
Pub Date : 2007-09-01 DOI: 10.1109/CIC.2007.4745588
E. Pueyo, E. Laciar, E. Anzuola, P. Laguna, R. Jané
In this study the slopes of the QRS complex are evaluated for determination of the degree of myocardial damage in chronic chagasic patients. Previous studies have demonstrated the ability of the slope indices to reflect alterations in the conduction velocity of the cardiac impulse. Results obtained in the present study show that chronic chagasic patients have significantly flatter QRS slopes as compared to healthy subjects. Not only that but the extent of slope lessening turns out to be proportional to the degree of myocardial damage caused by the disease. Additionally, when incorporating the slope indices into a classification analysis together with other indices indicative of the presence of ventricular late potentials obtained from high resolution electrocardiography, results show that the percentages of correct classification increase up to 62.5%, which means eight points above the percentages obtained prior to incorporation of the slope indices. It can be concluded that QRS slopes have great potential for assessing the degree of severity associated with Chagaspsila disease.
在这项研究中,QRS复合体的斜率被评估,以确定慢性chagasic患者的心肌损伤程度。先前的研究已经证明斜率指数能够反映心冲动传导速度的变化。本研究结果表明,与健康受试者相比,慢性恰加斯病患者的QRS斜率明显更平坦。不仅如此,坡度减小的程度与疾病对心肌的损害程度成正比。此外,当将斜率指数与高分辨率心电图显示的其他指示心室晚电位存在的指标一起纳入分类分析时,结果表明,正确分类的百分比提高了62.5%,比纳入斜率指数之前的百分比提高了8个百分点。由此可见,QRS斜率在评价桦尺蠖病的严重程度方面具有很大的潜力。
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引用次数: 6
Model-based approach to the localization of infarction 基于模型的梗死定位方法
Pub Date : 2007-09-01 DOI: 10.1109/CIC.2007.4745449
D. Farina, O. Dossel
A model-based approach to noninvasively determine the location and size of the infarction scar is proposed, that in addition helps to estimate the risk of arrhythmias. The approach is based on the optimization of an electrophysiological heart model with an introduced infarction scar to fit the multichannel ECG measured on the surface of the patient's thorax. This model delivers the distributions of transmembrane voltages (TMV) within the ventricles during a single heart cycle. The forward problem of electrocardiography is solved in order to obtain the simulated ECG of the patient. This ECG is compared with the measured one, the difference is used as the criterion for optimization of model parameters, which include the site and size of infarction scar.
提出了一种基于模型的无创方法来确定梗死疤痕的位置和大小,此外还有助于估计心律失常的风险。该方法是基于电生理心脏模型的优化,引入梗死疤痕,以适应在患者胸腔表面测量的多通道心电图。该模型提供了单个心脏周期内心室内跨膜电压(TMV)的分布。为了得到病人的模拟心电图,解决了心电图的正演问题。将该心电图与实测值进行比较,差异作为优化模型参数的标准,包括梗死疤痕的部位和大小。
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引用次数: 24
Organization deterioration assessment from the surface ECG in the onset and termination of paroxysmal atrial fibrillation 阵发性心房颤动起止时体表心电图组织恶化评价
Pub Date : 2007-09-01 DOI: 10.1109/CIC.2007.4745531
R. Alcaraz, J. J. Rieta
Recently, it has been suggested that many episodes of atrial fibrillation (AF) may be partially organized at the onset. Moreover, several clinical studies have demonstrated that an AF organization increase occurs prior to its spontaneous termination (paroxysmal AF), which could be used to predict the paroxysmal AF termination. However, although severals AF organization estimators based on invasive and non-invasive analysis have been proposed, the time course of organization in the first and last minutes of AF has not been quantified yet. Thereby, the aim of this work was to study the organization variations within the first and last minutes of paroxysmal AF episodes from surface ECG recordings making use of sample entropy. An organization decrease in the first minutes after AF onset and an increase within the last minute before spontaneous AF termination were obtained, these results were coincident with the conclusions presented in previous clinical works. Thus, it can be concluded that paroxysmal AF organization variations can be assessed from surface recordings without the need of invasive measurements.
最近,有研究表明,许多心房颤动(AF)发作可能在发病时部分有组织。此外,一些临床研究表明,房颤组织增加发生在其自发终止(阵发性房颤)之前,这可以用来预测阵发性房颤终止。然而,尽管已经提出了几种基于有创性和无创性分析的房颤组织估计方法,但房颤最初和最后几分钟的组织时间过程尚未被量化。因此,本研究的目的是利用样本熵,从体表心电图记录中研究阵发性心房颤动发作的第一和最后几分钟内的组织变化。AF发作后1分钟组织减少,AF自行终止前1分钟组织增加,这与以往临床工作的结论一致。因此,可以得出结论,阵发性心房颤动的组织变化可以从表面记录评估,而无需侵入性测量。
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引用次数: 0
Spatial properties and effects of ajmaline for epicardial propagation on isolated rabbit hearts: Measurements and a computer study 杨木碱对离体兔心脏心外膜传播的空间特性和影响:测量和计算机研究
Pub Date : 2007-09-01 DOI: 10.1109/CIC.2007.4745435
I. Legarreta, S. Bauer, R. W. dos Santos, H. Koch, M. Bar
Time-resolved surface activation time maps recorded from isolated rabbit hearts were analyzed in order to compare them with analogue maps generated by a computer model. Recordings were obtained under normal conditions as well as after the administration of ajmaline. In parallel, the measured quantities were simulated in a realistic computer model of the rabbit heart. The effect of ajmaline was reproduced by reducing the conductivity of sodium channels GNa in the model. It was observed that addition of a given amount of ajmaline leads to an increase of the QRS time of up to 33% and a decrease of typical velocities by 20-40% with respect to the normal conditions. The velocity speeds obtained display large variations. A velocity decrease of about 20% was reproduced in the computer model by a reduction of the parameter GNa by 60%. Such a change in the model induces a corresponding QRS time by 20%.
分析了从离体兔心脏记录的时间分辨表面激活时间图,以便与计算机模型生成的模拟图进行比较。分别在正常条件下和给药后进行记录。同时,测量的数量在一个真实的兔子心脏计算机模型中进行模拟。通过降低模型中钠通道GNa的电导率,再现了ajmaline的作用。结果表明,与正常条件相比,添加一定量的ajmaline可使QRS时间增加33%,典型速度降低20-40%。得到的速度变化很大。通过将参数GNa降低60%,在计算机模型中再现了大约20%的速度降低。模型的这种变化导致相应的QRS时间减少20%。
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引用次数: 3
Automatic detection of heart disease from twelve channel electrocardiogram waveforms 从十二通道心电图波形中自动检测心脏病
Pub Date : 2007-09-01 DOI: 10.1109/CIC.2007.4745609
T.G. Zimmerman, T. Syeda-Mahmood
A statistical means to automatically detect heart disease from twelve channel ECG waveforms is reported. Patient ECG records from the PTB Diagnostic ECG Database are assigned to one or more of 18 heart disease groups. A single heart beat cycle near the beginning of the record is used to measure eight temporal intervals (e.g. QT, ST, PR, QS) for each of the twelve channels, resulting in 96 parameters for each patient record. The average and standard deviation of the 96 parameters for 63 non-disease patients are used as a control reference. The number of parameters that exceed two times the standard deviation of the control reference is used as a disease indicator. Using ten or more out-of-bound parameters as the disease criteria, 72% of disease patient records are correctly identified while 8% of control patient records are falsely identified as having a heart disease.
报道了一种从12通道心电波形中自动检测心脏病的统计方法。来自PTB诊断心电图数据库的患者心电图记录被分配到18个心脏病组中的一个或多个。记录开始附近的单个心跳周期用于测量12个通道中每个通道的8个时间间隔(例如QT, ST, PR, QS),从而为每个患者记录产生96个参数。以63例非疾病患者96个参数的平均值和标准差作为对照参考。超过对照参考标准偏差两倍的参数数被用作疾病指标。使用10个或更多的越界参数作为疾病标准,72%的疾病患者记录被正确识别,而8%的对照患者记录被错误地识别为患有心脏病。
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引用次数: 11
期刊
2007 Computers in Cardiology
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