Background: Cholinesterase (ChE) inhibitors enhance central cholinergic function and are considered as standard treatments to ameliorate symptoms relating to Alzheimer's disease. Though anticholinergic medications directly antagonize the effects of ChE inhibitors, they are commonly prescribed among hospitalized adults. Objective: To determine the impact of high anticholinergic burden (ACB) on length of stay (LOS) and 30-day readmission rates among hospitalized patients receiving concomitant ChE inhibitors. Methods: This was a retrospective cohort study conducted at a tertiary care academic medical center involving hospitalized patients on medical floors who received any Food and Drug Administration-approved ChE inhibitors during their hospital stay from October 1, 2022, to September 30, 2023. The primary outcome of the study was to compare hospital LOS among patients with high (ACB ≥ 3) versus low (ACB < 3) ACB. The secondary outcome was to assess the impact of ACB burden on 30-day readmission rates. Results: Among hospitalized adults, patients with high ACB exposure had a significantly longer hospital LOS (median: 5.50 vs 4.25 days; P < 0.001) than patients with low ACB exposure, after adjusting for covariates. Analysis of secondary outcome revealed that though the high ACB group had a higher 30-day readmission rate compared with the lower ACB group (6.8% vs. 2.2%), the difference was not statistically significant (OR = 3.46, 95% CI 0.85-14.08; P = 0.083). Conclusion: A high ACB exposure among older individuals taking concurrent ChE inhibitors is associated with a longer hospital stay.
背景:胆碱酯酶(ChE)抑制剂增强中枢胆碱能功能,被认为是改善阿尔茨海默病相关症状的标准治疗方法。虽然抗胆碱能药物直接拮抗胆碱抑制剂的作用,但它们通常在住院成人中使用。目的:探讨高抗胆碱能负荷(ACB)对合并使用ChE抑制剂的住院患者住院时间(LOS)和30天再入院率的影响。方法:这是一项在三级医疗学术医疗中心进行的回顾性队列研究,涉及从2022年10月1日至2023年9月30日期间在医疗楼层接受任何食品和药物管理局批准的ChE抑制剂的住院患者。本研究的主要结局是比较ACB高(ACB≥3)和低(ACB < 3) ACB患者的医院LOS。次要结局是评估ACB负担对30天再入院率的影响。结果:在住院成人中,高ACB暴露的患者的住院LOS明显更长(中位数:5.50 vs 4.25天;在调整协变量后,P < 0.001)比低ACB暴露的患者。次要结局分析显示,虽然高ACB组的30天再入院率高于低ACB组(6.8%比2.2%),但差异无统计学意义(OR = 3.46, 95% CI 0.85-14.08;P = 0.083)。结论:在同时服用ChE抑制剂的老年人中,高ACB暴露与更长的住院时间有关。
{"title":"Examining the impact of Anticholinergic Burden on Hospitalized Older People Receiving Concomitant Cholinesterase inhibitors.","authors":"Jiajie Guan, John Noviasky, Jonathan H Watanabe","doi":"10.4140/TCP.n.2024.449","DOIUrl":"10.4140/TCP.n.2024.449","url":null,"abstract":"<p><p><b>Background:</b> Cholinesterase (ChE) inhibitors enhance central cholinergic function and are considered as standard treatments to ameliorate symptoms relating to Alzheimer's disease. Though anticholinergic medications directly antagonize the effects of ChE inhibitors, they are commonly prescribed among hospitalized adults. <b>Objective:</b> To determine the impact of high anticholinergic burden (ACB) on length of stay (LOS) and 30-day readmission rates among hospitalized patients receiving concomitant ChE inhibitors. <b>Methods:</b> This was a retrospective cohort study conducted at a tertiary care academic medical center involving hospitalized patients on medical floors who received any Food and Drug Administration-approved ChE inhibitors during their hospital stay from October 1, 2022, to September 30, 2023. The primary outcome of the study was to compare hospital LOS among patients with high (ACB ≥ 3) versus low (ACB < 3) ACB. The secondary outcome was to assess the impact of ACB burden on 30-day readmission rates. <b>Results:</b> Among hospitalized adults, patients with high ACB exposure had a significantly longer hospital LOS (median: 5.50 vs 4.25 days; <i>P</i> < 0.001) than patients with low ACB exposure, after adjusting for covariates. Analysis of secondary outcome revealed that though the high ACB group had a higher 30-day readmission rate compared with the lower ACB group (6.8% vs. 2.2%), the difference was not statistically significant (OR = 3.46, 95% CI 0.85-14.08; <i>P</i> = 0.083). <b>Conclusion:</b> A high ACB exposure among older individuals taking concurrent ChE inhibitors is associated with a longer hospital stay.</p>","PeriodicalId":41635,"journal":{"name":"Senior Care Pharmacist","volume":"39 12","pages":"449-457"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
While there is existing literature on medical ethics and geriatric care, this paper offers a unique perspective by examining the specific ethical challenges and obligations faced by pharmacists caring for older people. It provides a comprehensive ethical framework tailored to this specialized area of pharmacy practice. The findings and recommendations presented in this paper have significant implications for enhancing patient-centered, ethically grounded care for older people in pharmacy settings. It offers practical guidance for navigating complex ethical dilemmas and upholding the highest standards of care for this vulnerable population.
{"title":"Ethical Geriatric Pharmacy: Combating Ageism and Enhancing Patient Care.","authors":"Madeline M Yuzwa","doi":"10.4140/TCP.n.2024.441","DOIUrl":"10.4140/TCP.n.2024.441","url":null,"abstract":"<p><p>While there is existing literature on medical ethics and geriatric care, this paper offers a unique perspective by examining the specific ethical challenges and obligations faced by pharmacists caring for older people. It provides a comprehensive ethical framework tailored to this specialized area of pharmacy practice. The findings and recommendations presented in this paper have significant implications for enhancing patient-centered, ethically grounded care for older people in pharmacy settings. It offers practical guidance for navigating complex ethical dilemmas and upholding the highest standards of care for this vulnerable population.</p>","PeriodicalId":41635,"journal":{"name":"Senior Care Pharmacist","volume":"39 12","pages":"441-444"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Health care providers, at some point in their careers, will experience grief and loss of a patient. Grief is a natural response that many people experience, especially working in those fields such as community pharmacy, hospitals, hospice, and others. Pharmacists serve as community leaders and need to be properly trained early on how to deal with grief and loss both personally and within their teams. Pharmacist leaders can lead their team through hard times by developing a toolbox of skills. These skills include emotional intelligence, communication, and leadership skills to work through personal grief.
{"title":"Leading Pharmacists Who Experience Patient Loss.","authors":"Marlene Nguyen, Donna M Breese, Kristin Kellett","doi":"10.4140/TCP.n.2024.445","DOIUrl":"10.4140/TCP.n.2024.445","url":null,"abstract":"<p><p>Health care providers, at some point in their careers, will experience grief and loss of a patient. Grief is a natural response that many people experience, especially working in those fields such as community pharmacy, hospitals, hospice, and others. Pharmacists serve as community leaders and need to be properly trained early on how to deal with grief and loss both personally and within their teams. Pharmacist leaders can lead their team through hard times by developing a toolbox of skills. These skills include emotional intelligence, communication, and leadership skills to work through personal grief.</p>","PeriodicalId":41635,"journal":{"name":"Senior Care Pharmacist","volume":"39 12","pages":"445-448"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Notes on the Consultant Pharmacist Practice Model: At Home and Abroad.","authors":"Chad Worz","doi":"10.4140/TCP.n.2024.398","DOIUrl":"10.4140/TCP.n.2024.398","url":null,"abstract":"","PeriodicalId":41635,"journal":{"name":"Senior Care Pharmacist","volume":"39 11","pages":"398-400"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142565249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pharmacist Innovators: Redefining Roles, Elevating Care, Making Their Mark.","authors":"Leigh Davitian","doi":"10.4140/TCP.n.2024.432","DOIUrl":"10.4140/TCP.n.2024.432","url":null,"abstract":"","PeriodicalId":41635,"journal":{"name":"Senior Care Pharmacist","volume":"39 11","pages":"432-435"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142565253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"How Should the Scope of Pharmacy Practice Be Decided?","authors":"Chris Alderman","doi":"10.4140/TCP.n.2024.396","DOIUrl":"10.4140/TCP.n.2024.396","url":null,"abstract":"","PeriodicalId":41635,"journal":{"name":"Senior Care Pharmacist","volume":"39 11","pages":"396-397"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142565246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pharmacists are ideally situated and trained to educate and advocate for the proper use of inhaled medications among patients in the community. Proper inhaler technique is an important way to prevent exacerbations and manage the symptoms associated with chronic pulmonary diseases. The American Lung Association estimates almost 6 million people 65 years of age or older had a diagnosis of chronic obstructive pulmonary disease (COPD) in 2020 in the United States. However, published reports have found that less than 20% of older people with COPD use inhalers correctly. As inhalers are the primary route of administration for medications used to treat chronic airway diseases such as COPD, pharmacist-led education can help overcome the widespread lack of knowledge regarding proper inhaler use.
{"title":"Pharmacist Interventions for Inhaled Medication Use in Chronic Obstructive Pulmonary Disease (COPD).","authors":"Amanda Tam, Christian Nelson, Carla Bouwmeester","doi":"10.4140/TCP.n.2024.417","DOIUrl":"10.4140/TCP.n.2024.417","url":null,"abstract":"<p><p>Pharmacists are ideally situated and trained to educate and advocate for the proper use of inhaled medications among patients in the community. Proper inhaler technique is an important way to prevent exacerbations and manage the symptoms associated with chronic pulmonary diseases. The American Lung Association estimates almost 6 million people 65 years of age or older had a diagnosis of chronic obstructive pulmonary disease (COPD) in 2020 in the United States. However, published reports have found that less than 20% of older people with COPD use inhalers correctly. As inhalers are the primary route of administration for medications used to treat chronic airway diseases such as COPD, pharmacist-led education can help overcome the widespread lack of knowledge regarding proper inhaler use.</p>","PeriodicalId":41635,"journal":{"name":"Senior Care Pharmacist","volume":"39 11","pages":"417-424"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142565256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eposi Elonge, Catherine E Cooke, Merton Lee, Viviane Tang, Jodi-Ann Haynes, Sabrina Wang, Andrew Genuit, Brian Isetts, Karen Pellegrin, Judy Mikami, Del Price, Nicole Brandt
Background: Additional evidence is required to address the unintended consequences of medication use in older people and the required caregiver support. To inform priorities for future research efforts, different stakeholder perspectives are needed, including those of older people, caregivers, clinicians, and researchers. Objective: To develop a co-designed medication-related research agenda. Methods: A 12-member Advisory Council, half of which were older people and caregivers, designed the research. An 11-question survey to identify priorities for medication-related patient-centered outcomes research (PCOR) topics was administered to members of the Elder Care Medicine Network (ECMN) (ie, older people, caregivers, clinicians, and researchers). Respondents were categorized into two groups with hierarchical assignment to the clinician/research group over the older adult/caregiver group. Chi-square tests compared priority areas for medication-related PCOR between the two groups. Results: There were 53 responses (48% response rate) from the ECMN, with 39.6% (n = 21) from the clinician/researcher group and 60.4% (n = 32) from the older adult/caregiver group. The priority areas from both groups included safe ways to simplify medicines (62.2%), communicating with pharmacists and prescribers about medications (58.5%), and information about safe supplements with prescription medications (52.8%). Statistically significant differences existed between the two groups in the proportions choosing the priority areas. Conclusion: Co-design of a survey to identify priority areas for PCOR demonstrated successful engagement of older people and caregivers as research partners. While older people and caregivers may have differing perspectives on the importance of specific medication-related PCOR topics, simplifying medication regimen and health care communications were germane to both groups.
{"title":"Co-designing Medication Optimization Patient-Centered Outcomes Research With Older People and Caregivers as Research Partners.","authors":"Eposi Elonge, Catherine E Cooke, Merton Lee, Viviane Tang, Jodi-Ann Haynes, Sabrina Wang, Andrew Genuit, Brian Isetts, Karen Pellegrin, Judy Mikami, Del Price, Nicole Brandt","doi":"10.4140/TCP.n.2024.425","DOIUrl":"10.4140/TCP.n.2024.425","url":null,"abstract":"<p><p><b>Background:</b> Additional evidence is required to address the unintended consequences of medication use in older people and the required caregiver support. To inform priorities for future research efforts, different stakeholder perspectives are needed, including those of older people, caregivers, clinicians, and researchers. <b>Objective:</b> To develop a co-designed medication-related research agenda. <b>Methods:</b> A 12-member Advisory Council, half of which were older people and caregivers, designed the research. An 11-question survey to identify priorities for medication-related patient-centered outcomes research (PCOR) topics was administered to members of the Elder Care Medicine Network (ECMN) (ie, older people, caregivers, clinicians, and researchers). Respondents were categorized into two groups with hierarchical assignment to the clinician/research group over the older adult/caregiver group. Chi-square tests compared priority areas for medication-related PCOR between the two groups. <b>Results:</b> There were 53 responses (48% response rate) from the ECMN, with 39.6% (n = 21) from the clinician/researcher group and 60.4% (n = 32) from the older adult/caregiver group. The priority areas from both groups included safe ways to simplify medicines (62.2%), communicating with pharmacists and prescribers about medications (58.5%), and information about safe supplements with prescription medications (52.8%). Statistically significant differences existed between the two groups in the proportions choosing the priority areas. <b>Conclusion:</b> Co-design of a survey to identify priority areas for PCOR demonstrated successful engagement of older people and caregivers as research partners. While older people and caregivers may have differing perspectives on the importance of specific medication-related PCOR topics, simplifying medication regimen and health care communications were germane to both groups.</p>","PeriodicalId":41635,"journal":{"name":"Senior Care Pharmacist","volume":"39 11","pages":"425-431"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142565244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
President for the 2024-2025 year, Marsha Meyer sat down with ASCP's Director of Publications, Eleanor Smith, for an in-depth look at her career, her leadership style, and her plans for the association.
{"title":"Marsha Meyer PRESIDENT 2024-2025.","authors":"Eleanor Smith","doi":"10.4140/TCP.n.2024.401","DOIUrl":"https://doi.org/10.4140/TCP.n.2024.401","url":null,"abstract":"<p><p>President for the 2024-2025 year, Marsha Meyer sat down with ASCP's Director of Publications, Eleanor Smith, for an in-depth look at her career, her leadership style, and her plans for the association.</p>","PeriodicalId":41635,"journal":{"name":"Senior Care Pharmacist","volume":"39 11","pages":"401-406"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Marsha Meyer PRESIDENT 2024-2025.","authors":"Eleanor Smith","doi":"10.4140/TCP.n.2024.401","DOIUrl":"https://doi.org/10.4140/TCP.n.2024.401","url":null,"abstract":"","PeriodicalId":41635,"journal":{"name":"Senior Care Pharmacist","volume":"39 11","pages":"401-406"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142565247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}