Pub Date : 2024-10-10DOI: 10.1016/j.rechem.2024.101851
Valarmathi N, Sumathi Shanmugam
Herein, we reported the preparation of copper substituted hydroxyapatite (Cu-HAP) and fabrication of electrospun composites using Cu-HAP, SF (Silk fiber) and MC (Methylcellulose) by E-Spin method. Characterization techniques such as XRD (phase formation), FTIR (chemical bonds), SEM and EDAX (surface morphology and elemental composition) were carried out. Porosity measurement, swelling and mechanical properties were carried out to investigate the physicochemical properties of the fabricated electrospun composites. The hemocompatibility analysis indicated a hemolysis ratio < 2 %, which confirms the blood compatibility nature of the composite. Antibacterial activity of Copper hydroxyapatite/silk fiber/ Methylcellulose electrospun composite showed estimable activity against E.coli (zone of inhibition: 46 ± 0.94 mm) compared with pure SF/MC electrospun composite (33 ± 1.21). Bioactivity study confirmed the development of bone-like apatite on the surfaces of optimized (SF/MC 30 wt% of Cu-HAP) electrospun composite. Furthermore, MG63 cells were utilised to study the biocompatibility of the enhanced electrospun composite and good cell viability (99.93 ± 0.12 % using 25 μg/mL) was observed from microscopic image and the results showed that 30 wt% of Cu-HAP added polymer composite has outstanding osteoinductivity, biocompatibility, and antibacterial results, making it a very valuable aspirant for use in bone tissue engineering (BTE) applications to repair bone defects.
{"title":"Fabrication of copper ion-substituted hydroxyapatite/Silk fiber/Methylcellulose composite: mechanical, antimicrobial, hemocompatibility, bioactivity and cytocompatibility evaluation","authors":"Valarmathi N, Sumathi Shanmugam","doi":"10.1016/j.rechem.2024.101851","DOIUrl":"10.1016/j.rechem.2024.101851","url":null,"abstract":"<div><div>Herein, we reported the preparation of copper substituted hydroxyapatite (Cu-HAP) and fabrication of electrospun composites using Cu-HAP, SF (Silk fiber) and MC (Methylcellulose) by E-Spin method. Characterization techniques such as XRD (phase formation), FTIR (chemical bonds), SEM and EDAX (surface morphology and elemental composition) were carried out. Porosity measurement, swelling and mechanical properties were carried out to investigate the physicochemical properties of the fabricated electrospun composites. The hemocompatibility analysis indicated a hemolysis ratio < 2 %, which confirms the blood compatibility nature of the composite. Antibacterial activity of Copper hydroxyapatite/silk fiber/ Methylcellulose electrospun composite showed estimable activity against <em>E.coli</em> (zone of inhibition: 46 ± 0.94 mm) compared with pure SF/MC electrospun composite (33 ± 1.21). Bioactivity study confirmed the development of bone-like apatite on the surfaces of optimized (SF/MC 30 wt% of Cu-HAP) electrospun composite. Furthermore, MG63 cells were utilised to study the biocompatibility of the enhanced electrospun composite and good cell viability (99.93 ± 0.12 % using 25 μg/mL) was observed from microscopic image and the results showed that 30 wt% of Cu-HAP added polymer composite has outstanding osteoinductivity, biocompatibility, and antibacterial results, making it a very valuable aspirant for use in bone tissue engineering (BTE) applications to repair bone defects.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"12 ","pages":"Article 101851"},"PeriodicalIF":2.5,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-10DOI: 10.1016/j.rechem.2024.101845
Shoaib Khan , Rafaqat Hussain , Yousaf Khan , Tayyiaba Iqbal , Mohammad Shahidul Islam , Tahani Mazyad Almutairi
Coronavirus disease (COVID-19), an infectious disease caused by a newly discovered Coronavirus (severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was targeted in the current research study. Different hybrid thiadiazole based thiazolidinone derivatives were designed and successfully synthesized. Structural validation of novel compounds was achieved via spectroscopy by employing 1HNMR, 13CNMR, HREI-MS. All the synthesized compounds were biologically evaluated to study their potential to inhibit the main protease of SARS-CoV-2. The SAR data revealed that among the synthesized thiadiazole-based thiazolidinone derivatives showed significant inhibitory profile against the targeted enzymes. Different substituted compounds 1 (IC50 = 0.10 µM), 2 (IC50 = 1.43 µM), 4 (IC50 = 2.25 µM), 5 (IC50 = 24.56 µM), 6 (IC50 = 26.47 µM), and 8 (IC50 = 19.59 µM), were found with excellent potentials, even more potent than its standard GC-376 drug (IC50 = 0.439 µM). Among the potent candidates of the series, compound 1 bearing CF3 at meta and NO2 at ortho position exhibited the top ranking potential and emerged as the excellent inhibitor of protease of SARS-CoV-2. Furthermore, these potent analogues were subjected to molecular docking study in order to explore their bonding interactions with active sites of SARS-CoV-2 3CL protease. This study was also enriched with ADME analysis to evaluate drug-likeness of lead compounds of the series.
{"title":"Synthesis, confirmation based on in vitro and in silico study of thiadiazole-based thiazolidinone scaffolds: An approach toward Covid-19","authors":"Shoaib Khan , Rafaqat Hussain , Yousaf Khan , Tayyiaba Iqbal , Mohammad Shahidul Islam , Tahani Mazyad Almutairi","doi":"10.1016/j.rechem.2024.101845","DOIUrl":"10.1016/j.rechem.2024.101845","url":null,"abstract":"<div><div>Coronavirus disease (COVID-19), an infectious disease caused by a newly discovered Coronavirus (severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was targeted in the current research study. Different hybrid thiadiazole based thiazolidinone derivatives were designed and successfully synthesized. Structural validation of novel compounds was achieved via spectroscopy by employing <sup>1</sup>HNMR, <sup>13</sup>CNMR, HREI-MS. All the synthesized compounds were biologically evaluated to study their potential to inhibit the main protease of SARS-CoV-2. The SAR data revealed that among the synthesized thiadiazole-based thiazolidinone derivatives showed significant inhibitory profile against the targeted enzymes. Different substituted compounds <strong>1</strong> (IC<sub>50</sub> = 0.10 µM), <strong>2</strong> (IC<sub>50</sub> = 1.43 µM), <strong>4</strong> (IC<sub>50</sub> = 2.25 µM), <strong>5</strong> (IC<sub>50</sub> = 24.56 µM), <strong>6</strong> (IC<sub>50</sub> = 26.47 µM), and <strong>8</strong> (IC<sub>50</sub> = 19.59 µM), were found with excellent potentials, even more potent than its standard GC-376 drug (IC<sub>50</sub> = 0.439 µM). Among the potent candidates of the series, compound <strong>1</strong> bearing <img>CF<sub>3</sub> at <em>meta</em> and <img>NO<sub>2</sub> at <em>ortho</em> position exhibited the top ranking potential and emerged as the excellent inhibitor of protease of SARS-CoV-2. Furthermore, these potent analogues were subjected to molecular docking study in order to explore their bonding interactions with active sites of SARS-CoV-2 3CL protease. This study was also enriched with ADME analysis to evaluate drug-likeness of lead compounds of the series.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"12 ","pages":"Article 101845"},"PeriodicalIF":2.5,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142525904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Natural deep eutectic solvents (NADESs) have emerged as a novel class of solvents with properties reminiscent of ionic liquids while offering additional advantages in terms of cost, environmental impact, and synthesis. This article focuses on the applications of NADESs of mannose:urea and glucose:dimethylurea as inexpensive, accessible, and reusable catalysts in the synthesis of dihydropyrimidinone and polyhydroquinoline derivatives. The results demonstrate significant yields for both dihydropyrimidinones (47–99%) and polyhydroquinolines (90–97%) reactions using mannose:urea and glucose:dimethylurea as catalysts. The advantages of NADESs as catalysts include their simple and reproducible preparation, low cost, environmentally benign nature, long-term durability, and tunable properties. This NADESs can also be recovered and reused for four times without a significant loss of activity.
{"title":"One-pot synthesis of dihydropyrimidinone and polyhydroquinoline derivatives with natural deep eutectic solvents (NADESs): Alternative to toxic organic solvents and environmental eco-friendly","authors":"Sedigheh Ayazi Jannatabadi, Rahman Hosseinzadeh, Behrooz Maleki","doi":"10.1016/j.rechem.2024.101848","DOIUrl":"10.1016/j.rechem.2024.101848","url":null,"abstract":"<div><div>Natural deep eutectic solvents (NADESs) have emerged as a novel class of solvents with properties reminiscent of ionic liquids while offering additional advantages in terms of cost, environmental impact, and synthesis. This article focuses on the applications of NADESs of mannose:urea and glucose:dimethylurea as inexpensive, accessible, and reusable catalysts in the synthesis of dihydropyrimidinone and polyhydroquinoline derivatives. The results demonstrate significant yields for both dihydropyrimidinones (47–99%) and polyhydroquinolines (90–97%) reactions using mannose:urea and glucose:dimethylurea as catalysts. The advantages of NADESs as catalysts include their simple and reproducible preparation, low cost, environmentally benign nature, long-term durability, and tunable properties. This NADESs can also be recovered and reused for four times without a significant loss of activity.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"12 ","pages":"Article 101848"},"PeriodicalIF":2.5,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The widespread occurrence of chronic demyelinating MS presents a significant challenge for ongoing research aimed at comprehending its progression, diagnosis, and treatment. In our research, we have devised a novel approach to quantify CHI3L1 (Chitinase-3-like protein 1), which has emerged as a valuable biomarker in MS because of its involvement in inflammation, tissue remodeling, and immune response—crucial factors in regulating damaged nerve cells and preventing their accumulation in the brain, utilizing sandwich ELISA technology. This innovative method primarily depends on gold nanoparticles synthesized through a novel process of photo-irradiation with ultraviolet light. The crystal structure and particle size of sustainable zero-valent gold nanoparticles were measured using X-ray diffraction (XRD), which proved the cubic shape, with a cubic unit cell edge length of 4.0095 Å. The transmission electron microscopy (TEM) and field emission scanning electron microscope (FE-SEM) demonstrated that the distribution of Au NPs is uniform, with an average diameter of 22 nm. The UV–Vis spectrum, displaying a pronounced absorbance peak at a wavelength of 548 nm, suggests the presence of Au NPs. The optimal conditions for the formation of the Au-biotinylated antibody-HRP complex were studied. The optimum pH was 7, the dilution ratio of AuNPs with biotinylated antibody-HRP was 1:3, and the concentration of nanogold was (1 × 10−3 mg/ml) to avoid increasing it. Then a standard curve was drawn for this method and compared to the traditional method, and it was found to be twice as sensitive as the traditional method, with a high accuracy of CV% (3–6 %) as well as a rapid color generation for measurement. This method, based on gold nanoparticles that are considered a carrier for biotinylated antibody-HRP, was applied for the first time to measure CHI3L1 in the sera and cerebrospinal fluid of patients with multiple sclerosis, and the results demonstrated the accuracy and sensitivity of the method. The method has the potential to be an excellent tool for evaluating CHI3L1 and may have applications in other diseases for rapid diagnosis and timely treatment.
{"title":"A novel sandwich ELISA method for quantifying CHI3L1 in blood serum and cerebrospinal fluid multiple sclerosis patients using sustainable photo-irradiated zero-valence gold nanoparticles","authors":"Marwa Saad Mohammed, Salwa H.N. Al-Rubaeꞌi, Ahmed Mahdi Rheima, Fatin Fadhel Al-Kazazz","doi":"10.1016/j.rechem.2024.101856","DOIUrl":"10.1016/j.rechem.2024.101856","url":null,"abstract":"<div><div>The widespread occurrence of chronic demyelinating MS presents a significant challenge for ongoing research aimed at comprehending its progression, diagnosis, and treatment. In our research, we have devised a novel approach to quantify CHI3L1 (Chitinase-3-like protein 1), which has emerged as a valuable biomarker in MS because of its involvement in inflammation, tissue remodeling, and immune response—crucial factors in regulating damaged nerve cells and preventing their accumulation in the brain, utilizing sandwich ELISA technology. This innovative method primarily depends on gold nanoparticles synthesized through a novel process of photo-irradiation with ultraviolet light. The crystal structure and particle size of sustainable zero-valent gold nanoparticles were measured using X-ray diffraction (XRD), which proved the cubic shape, with a cubic unit cell edge length of 4.0095 Å. The transmission electron microscopy (TEM) and field emission scanning electron microscope (FE-SEM) demonstrated that the distribution of Au NPs is uniform, with an average diameter of 22 nm. The UV–Vis spectrum, displaying a pronounced absorbance peak at a wavelength of 548 nm, suggests the presence of Au NPs. The optimal conditions for the formation of the Au-biotinylated antibody-HRP complex were studied. The optimum pH was 7, the dilution ratio of AuNPs with biotinylated antibody-HRP was 1:3, and the concentration of nanogold was (1 × 10<sup>−3</sup> mg/ml) to avoid increasing it. Then a standard curve was drawn for this method and compared to the traditional method, and it was found to be twice as sensitive as the traditional method, with a high accuracy of CV% (3–6 %) as well as a rapid color generation for measurement. This method, based on gold nanoparticles that are considered a carrier for biotinylated antibody-HRP, was applied for the first time to measure CHI3L1 in the sera and cerebrospinal fluid of patients with multiple sclerosis, and the results demonstrated the accuracy and sensitivity of the method. The method has the potential to be an excellent tool for evaluating CHI3L1 and may have applications in other diseases for rapid diagnosis and timely treatment.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"11 ","pages":"Article 101856"},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-01DOI: 10.1016/j.rechem.2024.101843
Farzaneh Mohamadpour
For the preparation of polyfunctionalized piperidine scaffolds, a radical tandem five-condensation domino Knoevenagel-intramolecular [4 + 2] aza-Diels-Alder imin-based reaction was used. Based on acridine yellow G (AYG) as a photo-induced electron transfer (PET) photocatalyst, employing visible light as a renewable source of energy. AYG that is photochemically catalyzed has good yields, as well as outstanding atom economy, and ease of operation. As a result, a diverse set of chemical and environmental parameters can be measured across time. The turnover number (TON) and turnover frequency (TOF) of polyfunctionalized piperidine scaffolds have been computed. Also, gram-scale cyclization can occur, suggesting that the process might find application in industry.
{"title":"Acridine yellow G as a photo-induced electron transfer catalyzed radical [4 + 2] aza-Diels-Alder annulation of imines","authors":"Farzaneh Mohamadpour","doi":"10.1016/j.rechem.2024.101843","DOIUrl":"10.1016/j.rechem.2024.101843","url":null,"abstract":"<div><div>For the preparation of polyfunctionalized piperidine scaffolds, a radical tandem five-condensation domino Knoevenagel-intramolecular [4 + 2] aza-Diels-Alder imin-based reaction was used. Based on acridine yellow G (AYG) as a photo-induced electron transfer (PET) photocatalyst, employing visible light as a renewable source of energy. AYG that is photochemically catalyzed has good yields, as well as outstanding atom economy, and ease of operation. As a result, a diverse set of chemical and environmental parameters can be measured across time. The turnover number (TON) and turnover frequency (TOF) of polyfunctionalized piperidine scaffolds have been computed. Also, gram-scale cyclization can occur, suggesting that the process might find application in industry.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"11 ","pages":"Article 101843"},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-01DOI: 10.1016/j.rechem.2024.101830
R. Sakthi Murugan , Pitchai Sali Mohamed Hajasharif , C. Manoharan , A. Dinesh , S. Suthakaran , Manikandan Ayyar , Mohamed Hashem , Hassan Fouad
In this present study, pure Co3O4 and Cu-substituted Co3O4 nanoparticles (NPs) were prepared by a simple co-precipitation method and their structural, morphological, optical, and electrochemical properties were assessed. X-ray diffraction (XRD) analysis indicated that the synthesized samples had a cubic structure with the formation of a secondary phase (CuO) was detected at a higher Cu concentration. The average crystallite was decreased with increasing Cu content. Fourier transform infra-red (FT-IR) analysis revealed that the presence of vibrational bands in Cu-substituted Co3O4 NPs. The morphological study of the pure Co3O4 and Cu-substituted Co3O4 NPs revealed that the hexagonal structure with porous morphology confirmed by Field emission scanning electron microscopy (FESEM). High resolution transmission electron microscope (HR-TEM) analysis with spotty diffraction rings showed that pure Co3O4 and Cu-substituted Co3O4 NPs were polycrystalline in nature. The optical properties of synthesized samples exhibited strong absorption edges, and bandgap values were found to be increased from 3.60 to 3.75 eV. Cyclic voltammetry (CV) was employed to investigate the electrochemical properties of the synthesized materials. The CV curves exhibited pseudocapacitive behavior, and 2 % Cu substituted Co3O4 electrode had a high higher specific capacitance value than pure Co3O4 electrode.
本研究采用简单的共沉淀法制备了纯 Co3O4 和 Cu 取代 Co3O4 纳米粒子 (NPs)，并评估了它们的结构、形态、光学和电化学特性。X 射线衍射（XRD）分析表明，合成的样品具有立方结构，在较高的铜浓度下可检测到第二相（CuO）的形成。平均晶粒随着铜含量的增加而减少。傅立叶变换红外（FT-IR）分析表明，Cu 取代的 Co3O4 NPs 中存在振动带。场发射扫描电子显微镜（FESEM）对纯 Co3O4 和 Cu 取代 Co3O4 NPs 的形态研究表明，它们具有多孔的六边形结构。高分辨率透射电子显微镜（HR-TEM）和斑点衍射环分析表明，纯 Co3O4 和 Cu 取代 Co3O4 NPs 具有多晶性质。合成样品的光学特性表现出很强的吸收边缘，带隙值从 3.60 eV 增加到 3.75 eV。采用循环伏安法（CV）研究了合成材料的电化学特性。CV 曲线显示出假电容行为，2% 铜取代 Co3O4 电极的比电容值高于纯 Co3O4 电极。
{"title":"Effect of Cu substitution on morphological optical and electrochemical properties of Co3O4 nanoparticles by co-precipitation method","authors":"R. Sakthi Murugan , Pitchai Sali Mohamed Hajasharif , C. Manoharan , A. Dinesh , S. Suthakaran , Manikandan Ayyar , Mohamed Hashem , Hassan Fouad","doi":"10.1016/j.rechem.2024.101830","DOIUrl":"10.1016/j.rechem.2024.101830","url":null,"abstract":"<div><div>In this present study, pure Co<sub>3</sub>O<sub>4</sub> and Cu-substituted Co<sub>3</sub>O<sub>4</sub> nanoparticles (NPs) were prepared by a simple co-precipitation method and their structural, morphological, optical, and electrochemical properties were assessed. X-ray diffraction (XRD) analysis indicated that the synthesized samples had a cubic structure with the formation of a secondary phase (CuO) was detected at a higher Cu concentration. The average crystallite was decreased with increasing Cu content. Fourier transform infra-red (FT-IR) analysis revealed that the presence of vibrational bands in Cu-substituted Co<sub>3</sub>O<sub>4</sub> NPs. The morphological study of the pure Co<sub>3</sub>O<sub>4</sub> and Cu-substituted Co<sub>3</sub>O<sub>4</sub> NPs revealed that the hexagonal structure with porous morphology confirmed by Field emission scanning electron microscopy (FESEM). High resolution transmission electron microscope (HR-TEM) analysis with spotty diffraction rings showed that pure Co<sub>3</sub>O<sub>4</sub> and Cu-substituted Co<sub>3</sub>O<sub>4</sub> NPs were polycrystalline in nature. The optical properties of synthesized samples exhibited strong absorption edges, and bandgap values were found to be increased from 3.60 to 3.75 eV. Cyclic voltammetry (CV) was employed to investigate the electrochemical properties of the synthesized materials. The CV curves exhibited pseudocapacitive behavior, and 2 % Cu substituted Co<sub>3</sub>O<sub>4</sub> electrode had a high higher specific capacitance value than pure Co<sub>3</sub>O<sub>4</sub> electrode.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"11 ","pages":"Article 101830"},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-01DOI: 10.1016/j.rechem.2024.101802
Néomi Chefo Kengne , Honoré Wangso , Isaac Silvère Gade , Alphonse Laya , Jean Paul Bayang , Benoît Bargui Koubala , Sophie Laurent , Celine Henoumont , Emmanuel Talla
Phytochemical study of the root barks of Cassia arereh resulted in the isolation of a new phenolic ester, 3′-hydroxy-4′-methoxystyrenyl-(E)-p-coumarate (1) isolated for the first time from natural source, alongside eight known compounds (2–9). Compounds 1, 7 and 8 are depicted for the first time from Cassia genus. The structures of all compounds were established through NMR analysis (1D and 2D), High Resolution Mass Spectrometry (HRMS) and comparison with previously reported data in literature. Antioxidant activity was investigated through DPPH method while the antibacterial activity was done by the disc diffusion method on Escherichia coli and Salmonella typhimurium strains. Results showed that the methanol extract and compound 7 displayed significant (p < 0.01) DPPH radical scavenging activity which is comparable to BHT used as standard with IC50 values of 118.04 and 122.24 µg/mL respectively. Otherwise, the same extract and compound 7 also showed significant antibacterial activity against S. typhi and E. coli with MIC values of 30 and 40 µg/mL, respectively.
This research confirm the traditional use of Cassia arereh to treat ailments and provide supplementary data on its chemical profile and pharmacological potential.
{"title":"Antibacterial and antioxidant activities of a new phenolic coumpound from the roots barks of Cassia arereh Delile (Fabaceae)","authors":"Néomi Chefo Kengne , Honoré Wangso , Isaac Silvère Gade , Alphonse Laya , Jean Paul Bayang , Benoît Bargui Koubala , Sophie Laurent , Celine Henoumont , Emmanuel Talla","doi":"10.1016/j.rechem.2024.101802","DOIUrl":"10.1016/j.rechem.2024.101802","url":null,"abstract":"<div><div>Phytochemical study of the root barks of <em>Cassia arereh</em> resulted in the isolation of a new phenolic ester, 3′-hydroxy-4′-methoxystyrenyl-(<em>E</em>)-<em>p</em>-coumarate (<strong>1</strong>) isolated for the first time from natural source, alongside eight known compounds <strong>(2</strong>–<strong>9)</strong>. Compounds <strong>1, 7</strong> and <strong>8</strong> are depicted for the first time from <em>Cassia</em> genus. The structures of all compounds were established through NMR analysis (1D and 2D), High Resolution Mass Spectrometry (HRMS) and comparison with previously reported data in literature. Antioxidant activity was investigated through DPPH method while the antibacterial activity was done by the disc diffusion method on <em>Escherichia coli</em> and <em>Salmonella typhimurium</em> strains. Results showed that the methanol extract and compound 7 displayed significant (p < 0.01) DPPH radical scavenging activity which is comparable to BHT used as standard with IC<sub>50</sub> values of 118.04 and 122.24 µg/mL respectively. Otherwise, the same extract and compound <strong>7</strong> also showed significant antibacterial activity against <em>S. typhi</em> and <em>E. coli</em> with MIC values of 30 and 40 µg/mL, respectively.</div><div>This research confirm the traditional use of <em>Cassia arereh</em> to treat ailments and provide <span><span>supplementary data</span></span> on its chemical profile and pharmacological potential.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"11 ","pages":"Article 101802"},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142427103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-01DOI: 10.1016/j.rechem.2024.101817
Ibrahim Saeed Gataa , Zainab Younus Abdullah , Abdulrahman A. Almehizia , Amer Alhaj Zen , Soheil Salahshour , M. Pirmorad
{"title":"Corrigendum to “The impact of pH value on the transfer and release dynamics of doxorubicin facilitated by carbon nanotubes within the capillary network surrounding cancerous tumors through molecular dynamics simulation” [Res. Chem. 11 (2024) 101769]","authors":"Ibrahim Saeed Gataa , Zainab Younus Abdullah , Abdulrahman A. Almehizia , Amer Alhaj Zen , Soheil Salahshour , M. Pirmorad","doi":"10.1016/j.rechem.2024.101817","DOIUrl":"10.1016/j.rechem.2024.101817","url":null,"abstract":"","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"11 ","pages":"Article 101817"},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142531216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-01DOI: 10.1016/j.rechem.2024.101821
Sankarasekaran Shanmugaraju
{"title":"Chemical approaches for wastewater and pollutant treatment","authors":"Sankarasekaran Shanmugaraju","doi":"10.1016/j.rechem.2024.101821","DOIUrl":"10.1016/j.rechem.2024.101821","url":null,"abstract":"","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"11 ","pages":"Article 101821"},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142531214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-01DOI: 10.1016/j.rechem.2024.101839
Ali Talib al Alawi , Mohammad Talib al Alawi , Nasim Hayati Roodbari , Ali Es-haghi , Mohammad Mashreghi
The application of plant extracts for the biosynthesis of cobalt oxide nanoparticles is eco-friendly, more economical, less toxic, and more biocompatible. In this study, we used Rose hip extract to synthesize cobalt oxide nanoparticles (Co3O4 NPs). The biosynthesized cobalt oxide nanoparticles were characterized by FT-IR spectroscopy, X-ray diffraction (XRD), and scanning electron microscopy (SEM). The PXRD and FTIR analyses confirmed the successful synthesis and the characteristic bands of Co3O4 NPs, respectively. The FESEM image showed that the Co3O4 NPs were approximately spherical morphology with a mean size of 90.77 ± 32.35 nm. The EDX analysis showed the elemental composition contains carbon in the formulation of Co3O4 NPs. The results showed that the plant extracts can be used to synthesiz cobalt oxide nanoparticles with good quality at nanoscale sizes. The as-prepared Co3O4 NPs exhibited excellent cell toxicity properties against mouse colon adenocarcinoma cells, indicating that biosynthesized cobalt oxide nanoparticles have potential applications in cancer and nanomedicine.
{"title":"Biosynthesis of cobalt oxide nanoparticles and their cytotoxicity against cancer cells mouse colon adenocarcinoma cell line","authors":"Ali Talib al Alawi , Mohammad Talib al Alawi , Nasim Hayati Roodbari , Ali Es-haghi , Mohammad Mashreghi","doi":"10.1016/j.rechem.2024.101839","DOIUrl":"10.1016/j.rechem.2024.101839","url":null,"abstract":"<div><div>The application of plant extracts for the biosynthesis of cobalt oxide nanoparticles is eco-friendly, more economical, less toxic, and more biocompatible. In this study, we used Rose hip extract to synthesize cobalt oxide nanoparticles (Co<sub>3</sub>O<sub>4</sub> NPs). The biosynthesized cobalt oxide nanoparticles were characterized by FT-IR spectroscopy, X-ray diffraction (XRD), and scanning electron microscopy (SEM). The PXRD and FTIR analyses confirmed the successful synthesis and the characteristic bands of Co<sub>3</sub>O<sub>4</sub> NPs, respectively. The FESEM image showed that the Co<sub>3</sub>O<sub>4</sub> NPs were approximately spherical morphology with a mean size of 90.77 ± 32.35 nm. The EDX analysis showed the elemental composition contains carbon in the formulation of Co<sub>3</sub>O<sub>4</sub> NPs. The results showed that the plant extracts can be used to synthesiz cobalt oxide nanoparticles with good quality at nanoscale sizes. The as-prepared Co<sub>3</sub>O<sub>4</sub> NPs exhibited excellent cell toxicity properties against mouse colon adenocarcinoma cells, indicating that biosynthesized cobalt oxide nanoparticles have potential applications in cancer and nanomedicine.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"11 ","pages":"Article 101839"},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142427125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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