Results in Chemistry最新文献

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Synthesis, characterization and in-vitro study of hydroxyapatite, silver substituted hydroxyapatite and iron substituted hydroxyapatite for bone tissue engineering applications

IF 2.5 Q2 CHEMISTRY, MULTIDISCIPLINARY

Results in Chemistry

Pub Date : 2025-03-06 DOI: 10.1016/j.rechem.2025.102167

Sonia Sharma , Parveen Goyal

Calcium phosphate-based biomaterials resemble the inorganic composition of bone, they have attracted attention for bone tissue engineering applications. These compositions tend to develop an interface with the target bone because they are bioactive, bioresorbable, and biocompatible. Hydroxyapatite (HA) has gained importance among calcium phosphates because of its orthopaedic and dental applications.The ability of hydroxyapatite to exchange ions in the lattice framework allows the substitution of different ions to improve the resorbability of the ceramics. This study used a water-based sol-gel approach to create nano-dimensional HA and substituted (with ions Ag⁺ and Fe²⁺) nanopowders. X-ray florescence spectroscopy (XRF) was used for the compositional study, and X-ray diffraction (XRD) was used to ascertain the lattice parameters, phase transitions, purity, and crystallinity. FTIR, Fourier Transform Infrared Spectroscopy, was used to identify the functional groups. In-vitro study was performed by immersing the nanopowders at 37 °C in SBF for 30 days. The crystallinity of the nanopowders increased as the calcination temperature increased from 800 °C to 1200 °C. The crystallinnity of the calcined HA, Ag-HA, and Fe-HA, was found to be in the range of 85–98 %, 77–89 %, and 83–89 %, respectively. The mean crystallite size of the as-synthesized HA, Ag-HA, and Fe-HA nanopowders were 17.23 A^o, 9.155 A^o, and 9.4363 A^o, respectively. The mean crystallite sizes of the nanopowders increased with increase in the calcination.

{"title":"Synthesis, characterization and in-vitro study of hydroxyapatite, silver substituted hydroxyapatite and iron substituted hydroxyapatite for bone tissue engineering applications","authors":"Sonia Sharma , Parveen Goyal","doi":"10.1016/j.rechem.2025.102167","DOIUrl":"10.1016/j.rechem.2025.102167","url":null,"abstract":"<div><div>Calcium phosphate-based biomaterials resemble the inorganic composition of bone, they have attracted attention for bone tissue engineering applications. These compositions tend to develop an interface with the target bone because they are bioactive, bioresorbable, and biocompatible. Hydroxyapatite (HA) has gained importance among calcium phosphates because of its orthopaedic and dental applications.The ability of hydroxyapatite to exchange ions in the lattice framework allows the substitution of different ions to improve the resorbability of the ceramics. This study used a water-based sol-gel approach to create nano-dimensional HA and substituted (with ions Ag<sup>+</sup> and Fe<sup>2+</sup>) nanopowders. X-ray florescence spectroscopy (XRF) was used for the compositional study, and X-ray diffraction (XRD) was used to ascertain the lattice parameters, phase transitions, purity, and crystallinity. FTIR, Fourier Transform Infrared Spectroscopy, was used to identify the functional groups. In-vitro study was performed by immersing the nanopowders at 37 °C in SBF for 30 days. The crystallinity of the nanopowders increased as the calcination temperature increased from 800 °C to 1200 °C. The crystallinnity of the calcined HA, Ag-HA, and Fe-HA, was found to be in the range of 85–98 %, 77–89 %, and 83–89 %, respectively. The mean crystallite size of the as-synthesized HA, Ag-HA, and Fe-HA nanopowders were 17.23 A<sup>o</sup>, 9.155 A<sup>o</sup>, and 9.4363 A<sup>o</sup>, respectively. The mean crystallite sizes of the nanopowders increased with increase in the calcination.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"15 ","pages":"Article 102167"},"PeriodicalIF":2.5,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143610044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Probing the role of zinc ion in metallo-β-lactamase inhibitor binding by using multiple molecular dynamics simulations

IF 2.5 Q2 CHEMISTRY, MULTIDISCIPLINARY

Results in Chemistry

Pub Date : 2025-03-05 DOI: 10.1016/j.rechem.2025.102171

Guodong Zheng , Wuxia Liu , Yining Kang , Bing Xu , Xiaoou Qiu , Tingting Du , Shenqian Xu , Ruohua Chen , Hui Cheng , Chen Cai

The hydrolysis of the β-lactam ring of antibiotics mediated by Verona Integrin-encoded metallo-β-lactamase 2 (VIM-2) in the presence of two zinc ions (Zn1 and Zn2) leads to significant resistance toward β-lactam antibiotics. Here, multiple molecular dynamics (MD) simulations were performed on two systems, including VIM-2 with two Zn1 and Zn2 ions and a single Zn1 ion, to unravel the molecular mechanism of conformational changes of VIM-2 induced by the removal of Zn2 ion and the role of Zn2 in the binding of the VIM-2 inhibitor (ANT431). The results suggest that the binding of two zinc ions stabilizes the two flexible L3 and L10 loops constituting the binding site for ANT431, whereas in the presence of a single Zn1 ion, the L3 and L10 loops exhibit an enhanced conformational flexibility. Further structural analyses reveal that the binding of two zinc ions maintains a closed conformation of ANT431 binding site, while the ANT431 binding site mainly exists as an open conformation without the Zn2 ion. Consistently, ANT431 remains stable in the active site of VIM-2 in the presence of two zinc ions, while it escapes from the active site in the presence of a single Zn1 ion. We anticipate that our results may offer useful dynamical information pertaining to conformational changes of VIM-2 for the design of potent and selective inhibitors to alleviate drug resistance of VIM-2 toward antibiotics.

{"title":"Probing the role of zinc ion in metallo-β-lactamase inhibitor binding by using multiple molecular dynamics simulations","authors":"Guodong Zheng , Wuxia Liu , Yining Kang , Bing Xu , Xiaoou Qiu , Tingting Du , Shenqian Xu , Ruohua Chen , Hui Cheng , Chen Cai","doi":"10.1016/j.rechem.2025.102171","DOIUrl":"10.1016/j.rechem.2025.102171","url":null,"abstract":"<div><div>The hydrolysis of the β-lactam ring of antibiotics mediated by Verona Integrin-encoded metallo-β-lactamase 2 (VIM-2) in the presence of two zinc ions (Zn1 and Zn2) leads to significant resistance toward β-lactam antibiotics. Here, multiple molecular dynamics (MD) simulations were performed on two systems, including VIM-2 with two Zn1 and Zn2 ions and a single Zn1 ion, to unravel the molecular mechanism of conformational changes of VIM-2 induced by the removal of Zn2 ion and the role of Zn2 in the binding of the VIM-2 inhibitor (ANT431). The results suggest that the binding of two zinc ions stabilizes the two flexible L3 and L10 loops constituting the binding site for ANT431, whereas in the presence of a single Zn1 ion, the L3 and L10 loops exhibit an enhanced conformational flexibility. Further structural analyses reveal that the binding of two zinc ions maintains a closed conformation of ANT431 binding site, while the ANT431 binding site mainly exists as an open conformation without the Zn2 ion. Consistently, ANT431 remains stable in the active site of VIM-2 in the presence of two zinc ions, while it escapes from the active site in the presence of a single Zn1 ion. We anticipate that our results may offer useful dynamical information pertaining to conformational changes of VIM-2 for the design of potent and selective inhibitors to alleviate drug resistance of VIM-2 toward antibiotics.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"15 ","pages":"Article 102171"},"PeriodicalIF":2.5,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143580716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scaffolds of biologically active heterocyclic compounds for discovery of potential drug against SARS-CoV-2 用于发现抗 SARS-CoV-2 潜在药物的生物活性杂环化合物支架

IF 2.5 Q2 CHEMISTRY, MULTIDISCIPLINARY

Results in Chemistry

Pub Date : 2025-03-05 DOI: 10.1016/j.rechem.2025.102154

Archana R. Patil , Basappa C. Yallur , Geetika Pant , Eliza Ahmed , S.G. Prasanna Kumar , Sheetal R. Batakurki , Anjanapura V. Raghu

The unabated increase of severe acute respiratory syndrome coronavirus has wreaked havoc at a very large scale. In various direct and indirect ways, the non-living realm is also impacted. Severe health emergencies have broken out globally since 2002, with the advent of SARS CoV that was followed by the MERS CoV outbreak in 2012. The pandemic caused by the novel coronavirus, SARS CoV-2, that broke out in December 2019 in China has led to an approximate 76, 77,26, 861 confirmed cases and the death toll reported by the World Health Organization stands at 69,48,764 deaths. The WHO reported on 8 July 2023 that a total of 13.4 billion doses of vaccine have been administered globally. Heterocyclic scaffolds are exhaustively utilised since many decades for use as antimalarial, antitubercular, anti-inflammatory, antidiabetic, antimicrobial, anticancer and antiviral agents. In this review, therefore, we are emphasizing the expected role of cyclic frameworks and its compounds of nine common biologically important imidazoles, benzimidazoles, indoles, oxazoles, pyrazoles, pyridines, pyrimidines, pyrroles, and thiazoles in the design and discovery of novel drugs for combating SARS CoV-2. This has been done by the exploration of available scientific articles and literature that show a variety of heterocyclic moieties that target MERS, SARS and SARS CoV-2 viruses. The heterocyclic moiety and its derivatives discussed in this investigation may be considered essential sources for creating new approaches to treating the SARS coronavirus.

{"title":"Scaffolds of biologically active heterocyclic compounds for discovery of potential drug against SARS-CoV-2","authors":"Archana R. Patil , Basappa C. Yallur , Geetika Pant , Eliza Ahmed , S.G. Prasanna Kumar , Sheetal R. Batakurki , Anjanapura V. Raghu","doi":"10.1016/j.rechem.2025.102154","DOIUrl":"10.1016/j.rechem.2025.102154","url":null,"abstract":"<div><div>The unabated increase of severe acute respiratory syndrome coronavirus has wreaked havoc at a very large scale. In various direct and indirect ways, the non-living realm is also impacted. Severe health emergencies have broken out globally since 2002, with the advent of SARS CoV that was followed by the MERS CoV outbreak in 2012. The pandemic caused by the novel coronavirus, SARS CoV-2, that broke out in December 2019 in China has led to an approximate 76, 77,26, 861 confirmed cases and the death toll reported by the World Health Organization stands at 69,48,764 deaths. The WHO reported on 8 July 2023 that a total of 13.4 billion doses of vaccine have been administered globally. Heterocyclic scaffolds are exhaustively utilised since many decades for use as antimalarial, antitubercular, anti-inflammatory, antidiabetic, antimicrobial, anticancer and antiviral agents. In this review, therefore, we are emphasizing the expected role of cyclic frameworks and its compounds of nine common biologically important imidazoles, benzimidazoles, indoles, oxazoles, pyrazoles, pyridines, pyrimidines, pyrroles, and thiazoles in the design and discovery of novel drugs for combating SARS CoV-2. This has been done by the exploration of available scientific articles and literature that show a variety of heterocyclic moieties that target MERS, SARS and SARS CoV-2 viruses. The heterocyclic moiety and its derivatives discussed in this investigation may be considered essential sources for creating new approaches to treating the SARS coronavirus.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"15 ","pages":"Article 102154"},"PeriodicalIF":2.5,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143600389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in organic fluorophore-based Schiff base metal complexes: Applications in biomedicine and related fields

IF 2.5 Q2 CHEMISTRY, MULTIDISCIPLINARY

Results in Chemistry

Pub Date : 2025-03-05 DOI: 10.1016/j.rechem.2025.102166

Mani Rajasekar , Jennita Mary , Meenamigai Sivakumar , Showparnickaa Subburao Ravichandran , Dharshini Srinivasan

Schiff bases are formed through the condensation of primary amines with aldehydes or ketones. Due to their simple synthesis and versatile properties, they are highly favored as ligands in coordination chemistry. They are widely applied in fields such as biology, industry, food packaging, dyes, polymers, and oxygen detectors. Schiff base ligands are crucial in forming transition metal complexes, which serve as precursors for synthesizing metal and metal chalcogenide nanoparticles. Organic Fluorophore Schiff bases containing fluorophore groups have gained attention for their enhanced photophysical properties and broad pharmacological activities. Their metal complexes are efficient in catalyzing organic oxidation reactions. The structural diversity and ability to chelate metals make these compounds highly adaptable for various applications. This review explores the preparation, physical, biological properties, and catalytic applications of Organic Fluorophore Schiff bases metal complexes for biomedical applications.

{"title":"Recent advances in organic fluorophore-based Schiff base metal complexes: Applications in biomedicine and related fields","authors":"Mani Rajasekar , Jennita Mary , Meenamigai Sivakumar , Showparnickaa Subburao Ravichandran , Dharshini Srinivasan","doi":"10.1016/j.rechem.2025.102166","DOIUrl":"10.1016/j.rechem.2025.102166","url":null,"abstract":"<div><div>Schiff bases are formed through the condensation of primary amines with aldehydes or ketones. Due to their simple synthesis and versatile properties, they are highly favored as ligands in coordination chemistry. They are widely applied in fields such as biology, industry, food packaging, dyes, polymers, and oxygen detectors. Schiff base ligands are crucial in forming transition metal complexes, which serve as precursors for synthesizing metal and metal chalcogenide nanoparticles. Organic Fluorophore Schiff bases containing fluorophore groups have gained attention for their enhanced photophysical properties and broad pharmacological activities. Their metal complexes are efficient in catalyzing organic oxidation reactions. The structural diversity and ability to chelate metals make these compounds highly adaptable for various applications. This review explores the preparation, physical, biological properties, and catalytic applications of Organic Fluorophore Schiff bases metal complexes for biomedical applications.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"15 ","pages":"Article 102166"},"PeriodicalIF":2.5,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143593029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting mitochondrial ATP production of glioblastoma using sulfonamide and amide analogs of amantadine and memantine as metabolic inhibitors

IF 2.5 Q2 CHEMISTRY, MULTIDISCIPLINARY

Results in Chemistry

Pub Date : 2025-03-04 DOI: 10.1016/j.rechem.2025.102170

John E. Philo, Zachary C. Brandeburg, Tasfia R. Hasin, Ian J. Costello, Robert J. Sheaff, Angus A. Lamar

A library of 67 analogs of amantadine and memantine has been synthesized and screened for activity against 4 mammalian cell lines, including U-87 (glioblastoma). The library was screened using both a traditional cytotoxicity assay and a rapid assay to detect activity as metabolic inhibitors of ATP production. Two protocols were employed to identify activity targeting mitochondrial ATP (TCA cell cycle) production. In Protocol A (DMEM media + 2-DG), 16 compounds were identified as strong hits against U-87 cells at 50 μM. Using Protocol B (L-15 media), 10 compounds were identified as strong hits at 12.5 μM against U-87 cells. Several compounds were identified as hits toward U-87 cells using the rapid assay that were not identified using the traditional cytotoxicity assay. The IC₅₀ values of the hits against U-87 cells were determined against U-87 and non-cancerous HDF cells. The investigation has resulted in the identification of several compounds with the predicted ability to cross the blood-brain barrier that display high potency (0.82 μM for compound 20) and selectivity (selectivity index value ≥7 for compound 24) toward U-87 cells.

{"title":"Targeting mitochondrial ATP production of glioblastoma using sulfonamide and amide analogs of amantadine and memantine as metabolic inhibitors","authors":"John E. Philo, Zachary C. Brandeburg, Tasfia R. Hasin, Ian J. Costello, Robert J. Sheaff, Angus A. Lamar","doi":"10.1016/j.rechem.2025.102170","DOIUrl":"10.1016/j.rechem.2025.102170","url":null,"abstract":"<div><div>A library of 67 analogs of amantadine and memantine has been synthesized and screened for activity against 4 mammalian cell lines, including U-87 (glioblastoma). The library was screened using both a traditional cytotoxicity assay and a rapid assay to detect activity as metabolic inhibitors of ATP production. Two protocols were employed to identify activity targeting mitochondrial ATP (TCA cell cycle) production. In Protocol A (DMEM media + 2-DG), 16 compounds were identified as strong hits against U-87 cells at 50 μM. Using Protocol B (L-15 media), 10 compounds were identified as strong hits at 12.5 μM against U-87 cells. Several compounds were identified as hits toward U-87 cells using the rapid assay that were not identified using the traditional cytotoxicity assay. The IC<sub>50</sub> values of the hits against U-87 cells were determined against U-87 and non-cancerous HDF cells. The investigation has resulted in the identification of several compounds with the predicted ability to cross the blood-brain barrier that display high potency (0.82 μM for compound <strong>20</strong>) and selectivity (selectivity index value ≥7 for compound <strong>24</strong>) toward U-87 cells.</div><div>2009 Elsevier Ltd. All rights reserved.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"15 ","pages":"Article 102170"},"PeriodicalIF":2.5,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143563091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of Zn-doped CuSCN Nano-powders synthesized via an in situ method for enhanced optical and structural properties

IF 2.5 Q2 CHEMISTRY, MULTIDISCIPLINARY

Results in Chemistry

Pub Date : 2025-03-01 DOI: 10.1016/j.rechem.2025.102140

Enas Abdullah Al-Mahdi , A.M. Abdulwahab , Adnan Alnehia , Ahmed AL-Osta , Abdel-Baset Al-Odayni

This study investigates the influence of zinc doping on the physical properties of copper thiocyanate (CuSCN) nanopowders synthesized using an in situ method. Pure and zinc-doped CuSCN nanopowders were synthesized and characterized through a multi-technique approach, including scanning electron microscopy (SEM), UV–visible spectrophotometry, X-ray diffraction (XRD), electrical measurements, and antibacterial assays. XRD analysis confirmed the rhombohedral structure of all samples, with a slight increase in crystallite size observed in zinc-doped samples (1 % to 7 %) from 39.46 nm to 41.84 nm. The synthesized nanopowders exhibited antibacterial activity against both P. aeruginosa and S. aureus. Optical characterization revealed a decrease in both direct and indirect optical band gap energies with increasing zinc content. Furthermore, Zn doping resulted in an enhancement in the dc electrical conductivity of CuSCN. These findings suggest that zinc doping can improve the optoelectronic properties of CuSCN, making it a promising candidate for applications such as hole transport layers (HTLs) in solar cell devices.

{"title":"Characterization of Zn-doped CuSCN Nano-powders synthesized via an in situ method for enhanced optical and structural properties","authors":"Enas Abdullah Al-Mahdi , A.M. Abdulwahab , Adnan Alnehia , Ahmed AL-Osta , Abdel-Baset Al-Odayni","doi":"10.1016/j.rechem.2025.102140","DOIUrl":"10.1016/j.rechem.2025.102140","url":null,"abstract":"<div><div>This study investigates the influence of zinc doping on the physical properties of copper thiocyanate (CuSCN) nanopowders synthesized using an in situ method. Pure and zinc-doped CuSCN nanopowders were synthesized and characterized through a multi-technique approach, including scanning electron microscopy (SEM), UV–visible spectrophotometry, X-ray diffraction (XRD), electrical measurements, and antibacterial assays. XRD analysis confirmed the rhombohedral structure of all samples, with a slight increase in crystallite size observed in zinc-doped samples (1 % to 7 %) from 39.46 nm to 41.84 nm. The synthesized nanopowders exhibited antibacterial activity against both <em>P. aeruginosa</em> and <em>S. aureus</em>. Optical characterization revealed a decrease in both direct and indirect optical band gap energies with increasing zinc content. Furthermore, Zn doping resulted in an enhancement in the dc electrical conductivity of CuSCN. These findings suggest that zinc doping can improve the optoelectronic properties of CuSCN, making it a promising candidate for applications such as hole transport layers (HTLs) in solar cell devices.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"14 ","pages":"Article 102140"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143511500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of the anodic potential applied in the electrochemical synthesis of magnetite-chitosan nanoparticles on their physicochemical characteristics

IF 2.5 Q2 CHEMISTRY, MULTIDISCIPLINARY

Results in Chemistry

Pub Date : 2025-03-01 DOI: 10.1016/j.rechem.2025.102143

Ana Yareli Flores-Ramírez , Martina Alejandra Chacón-López , René Antaño-López , Alejandra Álvarez-López , Efigenia Montalvo-González , Alejandro Pérez-Larios , Rosa Isela Ortiz-Basurto , Aarón Rodríguez-López , Ulises Miguel López-García

Magnetite nanoparticles (MNp) have demonstrated applications in different areas due to their properties, such as magnetism, adsorption, biocompatibility, low toxicity, and antimicrobial activity, which mainly depend on the synthesis methods. However, current methods have some drawbacks, such as the presence of maghemite, the oxidation process and the poor control of particle size and distribution. Therefore, the synthesis by electrochemical methods of MNp is proposed, applying three different anodic potentials (0.8, 0.3 and − 0.2 V vs. Hg|Hg₂Cl₂) and its surface modification with chitosan (CS). In addition, in order to identify the effect of the anodic potentials in obtaining MNp and MNp modified with chitosan (MNp-CS), the characterization of these magnetic materials by physicochemical methods was carried out, through which it was demonstrated the obtaining of MNp and MNp-CS by field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and UV–vis spectrophptometry, in addition, it was observed that the MNp-CS synthesized at the anodic potentials of 0. 8 V and 0.3 V vs. Hg|Hg₂Cl₂ show higher colloidal stability, pore volume, specific surface area and magnetic properties, which could contribute to their efficiency to adsorb metal ions, dyes, and microorganisms.

{"title":"Effect of the anodic potential applied in the electrochemical synthesis of magnetite-chitosan nanoparticles on their physicochemical characteristics","authors":"Ana Yareli Flores-Ramírez , Martina Alejandra Chacón-López , René Antaño-López , Alejandra Álvarez-López , Efigenia Montalvo-González , Alejandro Pérez-Larios , Rosa Isela Ortiz-Basurto , Aarón Rodríguez-López , Ulises Miguel López-García","doi":"10.1016/j.rechem.2025.102143","DOIUrl":"10.1016/j.rechem.2025.102143","url":null,"abstract":"<div><div>Magnetite nanoparticles (MNp) have demonstrated applications in different areas due to their properties, such as magnetism, adsorption, biocompatibility, low toxicity, and antimicrobial activity, which mainly depend on the synthesis methods. However, current methods have some drawbacks, such as the presence of maghemite, the oxidation process and the poor control of particle size and distribution. Therefore, the synthesis by electrochemical methods of MNp is proposed, applying three different anodic potentials (0.8, 0.3 and − 0.2 V vs. Hg|Hg<sub>2</sub>Cl<sub>2</sub>) and its surface modification with chitosan (CS). In addition, in order to identify the effect of the anodic potentials in obtaining MNp and MNp modified with chitosan (MNp-CS), the characterization of these magnetic materials by physicochemical methods was carried out, through which it was demonstrated the obtaining of MNp and MNp-CS by field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and UV–vis spectrophptometry, in addition, it was observed that the MNp-CS synthesized at the anodic potentials of 0. 8 V and 0.3 V vs. Hg|Hg<sub>2</sub>Cl<sub>2</sub> show higher colloidal stability, pore volume, specific surface area and magnetic properties, which could contribute to their efficiency to adsorb metal ions, dyes, and microorganisms.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"14 ","pages":"Article 102143"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytotoxic effects of Methoxy-substituted Chalcones on glioblastoma stem cells: Computational target prediction and therapeutic insights

IF 2.5 Q2 CHEMISTRY, MULTIDISCIPLINARY

Results in Chemistry

Pub Date : 2025-03-01 DOI: 10.1016/j.rechem.2025.102122

Eduardo A. Veliz , Athina Yoham , Anastasiya Drandarov , Esther L. Abadi , Emanuella M. Brito , Maria Moreno Hollweg , Venkatesh Shanbhag , Roger M. Leblanc , Steven Vanni , Regina M. Graham

The prognosis for patients diagnosed with glioblastoma remains dismal with an average survival of about 15 months. Recently, it has been shown that glioblastoma stem-like cells (GSCs) drive tumor progression and are responsible for tumor regrowth following treatment; therefore, successful elimination of this cell population is necessary for disease eradication. Methoxy substituted chalcones have demonstrated anti-cancer effects with diverse molecular mechanisms. In this study, we synthesized 24 methoxy containing compounds, including 5 novel compounds, and tested their cytotoxicity toward 3 GSC lines and 2 non-tumor cell lines. We identified 13 compounds demonstrating an average GSC IC₅₀ value below 10 μM, many of which were less toxic to the non-cancer cell lines. In silico reverse screening identified probable targets for 7 out of the 13 active compounds. Some targets have been well-investigated such as the epidermal growth factor receptor; however, others such as 17-beta hydroxysteroid dehydrogenase type 3 warrant further study.

{"title":"Cytotoxic effects of Methoxy-substituted Chalcones on glioblastoma stem cells: Computational target prediction and therapeutic insights","authors":"Eduardo A. Veliz , Athina Yoham , Anastasiya Drandarov , Esther L. Abadi , Emanuella M. Brito , Maria Moreno Hollweg , Venkatesh Shanbhag , Roger M. Leblanc , Steven Vanni , Regina M. Graham","doi":"10.1016/j.rechem.2025.102122","DOIUrl":"10.1016/j.rechem.2025.102122","url":null,"abstract":"<div><div>The prognosis for patients diagnosed with glioblastoma remains dismal with an average survival of about 15 months. Recently, it has been shown that glioblastoma stem-like cells (GSCs) drive tumor progression and are responsible for tumor regrowth following treatment; therefore, successful elimination of this cell population is necessary for disease eradication. Methoxy substituted chalcones have demonstrated anti-cancer effects with diverse molecular mechanisms. In this study, we synthesized 24 methoxy containing compounds, including 5 novel compounds, and tested their cytotoxicity toward 3 GSC lines and 2 non-tumor cell lines. We identified 13 compounds demonstrating an average GSC IC<sub>50</sub> value below 10 μM, many of which were less toxic to the non-cancer cell lines. <em>In silico</em> reverse screening identified probable targets for 7 out of the 13 active compounds. Some targets have been well-investigated such as the epidermal growth factor receptor; however, others such as 17-beta hydroxysteroid dehydrogenase type 3 warrant further study.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"14 ","pages":"Article 102122"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New series of aromatic amides hybrids derivatives as anti-Alzheimer's drugs: Design, synthesis, biological activity and computational studies

IF 2.5 Q2 CHEMISTRY, MULTIDISCIPLINARY

Results in Chemistry

Pub Date : 2025-03-01 DOI: 10.1016/j.rechem.2025.102138

Lin Chen , Si-Lu Sun , He-Yang Zhong , Dan Wan , Fei Feng , Shuai Huang , Xian-Li Zhou

Alzheimer's disease (AD) is a degenerative disease of the central nervous system with complex pathogenesis there is an urgent need to develop more relevant agents. Since Gx-50 has some anti-AD activity and its cinnamic acid fragment can be regarded as an advantaged fragment, it was suggested to splice it and similar fragment to compound 3 which showed anti-AD activities in previous work. Then 20 compounds were obtained and among them, compound 1b has better acetylcholinesterase inhibitory activity (IC₅₀ = 0.29 μM), which was equivalent to the positive drug donepezil, and its molecular docking showed cinnamic acid part of compound 1b provide more bind possibilities with hAChE. Also, compound 1b showed neuroprotection effect (cell survival rate is 76.72 % at 12.5 μM), and revealed by ROS analysis and immunofluorescence, its neuroprotection activity may act by reducing ROS-induced oxidative stress. Besides, 10b also exhibits activity in inhibiting acetylcholinesterase (IC₅₀ = 0.31 μM) and Aβ aggregation (IC₅₀ = 25.0 μM), making it potential for further development. In summary, it studied the feasibility of molecular hybridization, adn provided new promising multi-functional agent for anti-AD.

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引用次数: 0

One-step phytosynthesis of Co3O4 nanoparticles and study of their catalytic, antioxidant, antibiofilm and antibacterial activities

IF 2.5 Q2 CHEMISTRY, MULTIDISCIPLINARY

Results in Chemistry

Pub Date : 2025-03-01 DOI: 10.1016/j.rechem.2025.102151

Naseem Akhter , Amina Liaquat , Farah Murtaza , Asma Yaqoob , Shabnum Sharif , Nagina Jummah , Muhammad Imran Khan , Abdallah Shanableh , Leonid G. Voskressensky , Rafael Luque

Co₃O₄ nanoparticles (NPs) were synthesized using Citrus lemon leaf extract, a novel green method. The synthesized NPs were extensively characterized using FTIR, UV-VIS, XRD, and SEM techniques, confirming their synthesis and properties. These NPs demonstrated promising catalytic efficiency (% degradation = 75.16 %), antioxidant potential (IC50 = 0.7 mg/ml), anti-biofilm activity (IC50 = 0.096 ± 0.005 mg/ml for E. coli, 0.08 ± 0.007 mg/ml for S. aureus) and antibacterial effects (ZOI = 28 mm for E. coli, 23 mm for S. aureus). This green synthesis method offers scalability and cost-effectiveness as compared to the energy-intensive and wasteful traditional methods. Our study exemplifies a commitment to advancing scientific progress through sustainable practices, contributing to global sustainable development goals.

引用次数: 0

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