Pub Date : 2025-01-25DOI: 10.1016/j.rechem.2025.102075
Yen Nguyen , Greg Petruncio , Schroeder M. Noble , Mikell Paige
Many compounds containing the pyrazolo[3,4-b]pyridine scaffold have been found to have various pharmacological activities such as anticancer, anti-inflammatory, anti-bacterial, antihyperglycemic, and anxiolytic properties. In general, low water solubility often hinders bioassay screening of small molecules. In this work, we have prepared a series of 1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid analogues through the condensation of 5-aminopyrazoles with aromatic aldehydes and pyruvic acid. We then converted the carboxylic acid handle on these heterocycles into the corresponding sodium salt, which improved the water solubility.
{"title":"Synthesis of 1H-pyrazolo[3,4-b]pyridine analogues","authors":"Yen Nguyen , Greg Petruncio , Schroeder M. Noble , Mikell Paige","doi":"10.1016/j.rechem.2025.102075","DOIUrl":"10.1016/j.rechem.2025.102075","url":null,"abstract":"<div><div>Many compounds containing the pyrazolo[3,4-<em>b</em>]pyridine scaffold have been found to have various pharmacological activities such as anticancer, anti-inflammatory, anti-bacterial, antihyperglycemic, and anxiolytic properties. In general, low water solubility often hinders bioassay screening of small molecules. In this work, we have prepared a series of 1<em>H</em>-pyrazolo[3,4-<em>b</em>]pyridine-4-carboxylic acid analogues through the condensation of 5-aminopyrazoles with aromatic aldehydes and pyruvic acid. We then converted the carboxylic acid handle on these heterocycles into the corresponding sodium salt, which improved the water solubility.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"14 ","pages":"Article 102075"},"PeriodicalIF":2.5,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143155929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
According to Sustainable DevelopmentGoals (SDG6) access to clean; disinfected water is the most essential human need for prosperity and overall wellness. Billions of people won’t have access to these fundamental services by the end of 2030 unless there is a fourfold increase in global progress. Water contamination by heavy metal pollution is initiated by quick industrialization and urbanization. The ecosystem, including humans and other living things, is in danger because metals are contaminate accessible water supplies. The pollutants in the surface and groundwater, exhibit major toxic characteristics that can pose a severe risk to both people and aquatic life. The drawbacks of various other removal/treatment techniques were analyzed, and the preferred method is adsorption because of its lower usage of chemicals and eco-friendly technique. Owing to enhanced surface acquisition and magnetic qualities, magnetic nanomaterials (MNPs), zero-valent iron (nZVI) and the nZVI incorporated with activated carbon have ample applications in remediating environmental contaminants. These materials were developed using a variety of re-modeling strategies. Furthermore, this paper provides an overview of the sorbent for eradicating toxic contaminants and encompasses exciting opportunities and challenges for research and developing technology improvement through both distinctive as well as efficient strategies.
{"title":"Magnetic Nanoparticles: Synthesis, characterization and application based on environmental Perspective","authors":"Prabu Deivasigamani , Vasu Gajendiran , B. Chitra , P.Senthil Kumar , Nivya Balasubramanian , Sathish Sundararaman , Venkatesan Dhananjeyan , Lalithambegai Subramani , Aravind Kumar Jagadeesan , Selvaraju Sivamani , Rathna Chellappa , Gayathri Rangasamy","doi":"10.1016/j.rechem.2025.102023","DOIUrl":"10.1016/j.rechem.2025.102023","url":null,"abstract":"<div><div>According to Sustainable DevelopmentGoals (SDG6) access to clean; disinfected water is the most essential human need for prosperity and overall wellness. Billions of people won’t have access to these fundamental services by the end of 2030 unless there is a fourfold increase in global progress. Water contamination by heavy metal pollution is initiated by quick industrialization and urbanization. The ecosystem, including humans and other living things, is in danger because metals are contaminate accessible water supplies. The pollutants in the surface and groundwater, exhibit major toxic characteristics that can pose a severe risk to both people and aquatic life. The drawbacks of various other removal/treatment techniques were analyzed, and the preferred method is adsorption because of its lower usage of chemicals and eco-friendly technique. Owing to enhanced surface acquisition and magnetic qualities, magnetic nanomaterials (MNPs), zero-valent iron (nZVI) and the nZVI incorporated with activated carbon have ample applications in remediating environmental contaminants. These materials were developed using a variety of re-modeling strategies. Furthermore, this paper provides an overview of the sorbent for eradicating toxic contaminants and encompasses exciting opportunities and challenges for research and developing technology improvement through both distinctive as well as efficient strategies.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"14 ","pages":"Article 102023"},"PeriodicalIF":2.5,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143155074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-23DOI: 10.1016/j.rechem.2025.102063
Weynshet Alamaw , Abi M. Taddesse , Abebaw Adgo , Zewdu Bezu , Endale Teju
Co-precipitation was used to produce single, binary, and ternary systems of CdS/TiO2:Ag2CO3 with varied molar ratios (1:2, 1:3, and 1:4). The impregnation method was also used to fabricate a zeolite-supported CdS/TiO2/Ag2CO3 (ZST) composite. XRD, UV–Vis, FTIR, PL, CV, and EIS instruments were employed to investigate the crystal structure, electronic properties, functional groups, optical characteristics, and other properties of the as-prepared composites. The photodegradation studies of all as-produced photocatalysts were assessed employing a solution of model contaminant methyl orange (MO) and real effluent taken from the Bahir Dar Textile Industry. The photodegradation measurements of the CdS/TiO2/Ag2CO3 composite (1:2, 1:3, and 1:4) were shown to be superior to those of single and hybrid constituents due to producing an additional avenue for the generation of e−-h+ pairs. Using a zeolite-supported CdS/TiO2/Ag2CO3 (ZST) composite, the influence of operative variables like pH, initial dye quantity, and photocatalyst load on MO dye discoloration was examined. At ideal settings, the percent degradation efficiency for the naked CdS/TiO2/Ag2CO3 (T1) and zeolite-supported CdS/TiO2/Ag2CO3 (ZST) ternary-based composites on the model dye were 82.4 and 91.6 %, respectively. The influence of various trapping agents reveals that the primary species engaged in the decolorization of MO were •O2− and •OH. The zeolite-supported photocatalyst also had a greater photodegradation efficiency of MO than real effluent samples, with 92.1 and 73.8 %, respectively.
{"title":"Synthesis and characterization of zeolite-supported CdS/TiO2/Ag2CO3 ternary composite for Photodegradation of methyl Orange","authors":"Weynshet Alamaw , Abi M. Taddesse , Abebaw Adgo , Zewdu Bezu , Endale Teju","doi":"10.1016/j.rechem.2025.102063","DOIUrl":"10.1016/j.rechem.2025.102063","url":null,"abstract":"<div><div>Co-precipitation was used to produce single, binary, and ternary systems of CdS/TiO<sub>2</sub>:Ag<sub>2</sub>CO<sub>3</sub> with varied molar ratios (1:2, 1:3, and 1:4). The impregnation method was also used to fabricate a zeolite-supported CdS/TiO<sub>2</sub>/Ag<sub>2</sub>CO<sub>3</sub> (ZST) composite. XRD, UV–Vis, FTIR, PL, CV, and EIS instruments were employed to investigate the crystal structure, electronic properties, functional groups, optical characteristics, and other properties of the as-prepared composites. The photodegradation studies of all as-produced photocatalysts were assessed employing a solution of model contaminant methyl orange (MO) and real effluent taken from the Bahir Dar Textile Industry. The photodegradation measurements of the CdS/TiO<sub>2</sub>/Ag<sub>2</sub>CO<sub>3</sub> composite (1:2, 1:3, and 1:4) were shown to be superior to those of single and hybrid constituents due to producing an additional avenue for the generation of e<sup>−</sup>-h<sup>+</sup> pairs. Using a zeolite-supported CdS/TiO<sub>2</sub>/Ag<sub>2</sub>CO<sub>3</sub> (ZST) composite, the influence of operative variables like pH, initial dye quantity, and photocatalyst load on MO dye discoloration was examined. At ideal settings, the percent degradation efficiency for the naked CdS/TiO<sub>2</sub>/Ag<sub>2</sub>CO<sub>3</sub> (T1) and zeolite-supported CdS/TiO<sub>2</sub>/Ag<sub>2</sub>CO<sub>3</sub> (ZST) ternary-based composites on the model dye were 82.4 and 91.6 %, respectively. The influence of various trapping agents reveals that the primary species engaged in the decolorization of MO were <sup>•</sup>O<sub>2</sub><sup>−</sup> and <sup>•</sup>OH. The zeolite-supported photocatalyst also had a greater photodegradation efficiency of MO than real effluent samples, with 92.1 and 73.8 %, respectively.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"14 ","pages":"Article 102063"},"PeriodicalIF":2.5,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143155105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-23DOI: 10.1016/j.rechem.2025.102066
Gopal Niraula , Jose A.H. Coaquira , Edgar Obed Pérez Reyes , Yasir Javed , Edilso Reguera , Joel Garcia , Surender Kumar Sharma
We present hydrothermally prepared Fe3O4 microparticles with diverse morphologies such as long micro-rods (LMRs), short micro-rods (SMRs), and micro-disks (MDs) through thermal-reduction of α-Fe2O3as support during the crystallization processes. The impact of PO43− anions was systematically explored with significant influence on tuning the prepared materials' sizes/shapes and phase composition/stoichiometry. A lower concentration of PO43− anions promotes the growth of a mixed iron-oxide phase, for instance, LMRs/SMRs; whereas a higher one results in a pure single-phase cubic Fe3O4structure (MDs) The line shape of the Fe2p region using the multiplets splitting model suggests that Fe3O4 is mainly present at the surface as validated through Mossbauer spectroscopy. Magnetization measurements revealed an alteration of the Verwey transition from LMRs/SMRs to MDs. Further, these microstructures were examined for their efficiencies in adjusting the hyperthermia response, with specific absorption rates peaking from 2.8 to 3.4 W/g and are noticeably dominated by the shape anisotropy.
{"title":"Hydrothermally synthesized Fe3O4 microparticles: Structural, magnetic, Mössbauer and magneto-hyperthermia properties","authors":"Gopal Niraula , Jose A.H. Coaquira , Edgar Obed Pérez Reyes , Yasir Javed , Edilso Reguera , Joel Garcia , Surender Kumar Sharma","doi":"10.1016/j.rechem.2025.102066","DOIUrl":"10.1016/j.rechem.2025.102066","url":null,"abstract":"<div><div>We present hydrothermally prepared Fe<sub>3</sub>O<sub>4</sub> microparticles with diverse morphologies such as long micro-rods (LMRs), short micro-rods (SMRs), and micro-disks (MDs) through thermal-reduction of α-Fe<sub>2</sub>O<sub>3</sub>as support during the crystallization processes. The impact of PO<sub>4</sub><sup>3−</sup> anions was systematically explored with significant influence on tuning the prepared materials' sizes/shapes and phase composition/stoichiometry. A lower concentration of PO<sub>4</sub><sup>3−</sup> anions promotes the growth of a mixed iron-oxide phase, for instance, LMRs/SMRs; whereas a higher one results in a pure single-phase cubic Fe<sub>3</sub>O<sub>4</sub>structure (MDs) The line shape of the Fe2p region using the multiplets splitting model suggests that Fe<sub>3</sub>O<sub>4</sub> is mainly present at the surface as validated through Mossbauer spectroscopy. Magnetization measurements revealed an alteration of the Verwey transition from LMRs/SMRs to MDs. Further, these microstructures were examined for their efficiencies in adjusting the hyperthermia response, with specific absorption rates peaking from 2.8 to 3.4 W/g and are noticeably dominated by the shape anisotropy.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"14 ","pages":"Article 102066"},"PeriodicalIF":2.5,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143155098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-23DOI: 10.1016/j.rechem.2025.102061
N. Askarzadeh , H. Shokrollahi , L. Karimi
Yttrium iron garnet (YIG) is a widely studied magnetic ceramic known for its low magnetic damping, high electrical resistivity, and low dielectric losses, which make it essential for various applications like microwave and radar systems, spintronic devices, oscillators, filters, phase shifters, and magneto-optical devices. The performance of YIG is closely linked to its physical properties, such as exchange interactions, Curie temperature, magnetic anisotropy, magneto-optic effects, and spin-wave dynamics. In recent years, there has been a growing interest in the impact of doping, particularly with rare earth, bismuth, and strontium elements, on YIG’s properties. Rare earth ions, with their shielded 4f electrons, introduce unique modifications in the dodecahedral sub-lattice, influencing phase formation, structural characteristics, magnetic behavior, and optical performance. This review aims to provide a comprehensive overview of how doping with rare earth elements, bismuth, and strontium affects YIG. It also highlights recent advances in synthesis methods, property optimization, and emerging applications, while emphasizing the role of dopants in tuning YIG for next-generation magneto-optical and spintronic technologies. Finally, the review identifies existing research gaps and suggests potential directions for future studies in this exciting area.
{"title":"Yttrium iron garnet: Dodecahedral substitutions","authors":"N. Askarzadeh , H. Shokrollahi , L. Karimi","doi":"10.1016/j.rechem.2025.102061","DOIUrl":"10.1016/j.rechem.2025.102061","url":null,"abstract":"<div><div>Yttrium iron garnet (YIG) is a widely studied magnetic ceramic known for its low magnetic damping, high electrical resistivity, and low dielectric losses, which make it essential for various applications like microwave and radar systems, spintronic devices, oscillators, filters, phase shifters, and magneto-optical devices. The performance of YIG is closely linked to its physical properties, such as exchange interactions, Curie temperature, magnetic anisotropy, magneto-optic effects, and spin-wave dynamics. In recent years, there has been a growing interest in the impact of doping, particularly with rare earth, bismuth, and strontium elements, on YIG’s properties. Rare earth ions, with their shielded 4f electrons, introduce unique modifications in the dodecahedral sub-lattice, influencing phase formation, structural characteristics, magnetic behavior, and optical performance. This review aims to provide a comprehensive overview of how doping with rare earth elements, bismuth, and strontium affects YIG. It also highlights recent advances in synthesis methods, property optimization, and emerging applications, while emphasizing the role of dopants in tuning YIG for next-generation magneto-optical and spintronic technologies. Finally, the review identifies existing research gaps and suggests potential directions for future studies in this exciting area.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"14 ","pages":"Article 102061"},"PeriodicalIF":2.5,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143155072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-23DOI: 10.1016/j.rechem.2025.102067
Fatemeh Masoumi, Rahim Mohammad-Rezaei, Mahdi Golmohammadpour
In this research, two different types of layered double hydroxides (LDHs) based on FeNi and CoNi were electrosynthesized on the surface of carbon ceramic electrode (CCE) as a renewable and polishable substrate and their electrocatalytic response for the detection of glucose in saliva samples were studied. Active surface area and electron transfer performance of CCE/Co-Ni-LDH and CCE/Fe-Ni-LDH were investigated in detail revealing that cobalt is more efficient than iron for intercalation in the LDH structure for electrocatalytic purposes. Based on experimental studies using the chronoamperometry method in the optimized condition, the detection limit, linear range, and sensitivity of the prepared CCE/Co-Ni-LDH for the glucose measurement were found to be 0.104 μM, 0.5–33 μM, and 6.4890 μA μM−1 cm−2 respectively, which were remarkably better than CCE/Fe-Ni-LDH. The fastness of the preparation process, renewable surface, and improved analytical performance enabled CCE/Co-Ni-LDH to be a practical sensor for glucose detection in human saliva samples with satisfactory results.
{"title":"Electrosynthesis of coNi and FeNi LDHs and studying the effect of intercalated cobalt and iron on the electrocatalysis and determination of glucose in human salivary samples","authors":"Fatemeh Masoumi, Rahim Mohammad-Rezaei, Mahdi Golmohammadpour","doi":"10.1016/j.rechem.2025.102067","DOIUrl":"10.1016/j.rechem.2025.102067","url":null,"abstract":"<div><div>In this research, two different types of layered double hydroxides (LDHs) based on Fe<img>Ni and Co<img>Ni were electrosynthesized on the surface of carbon ceramic electrode (CCE) as a renewable and polishable substrate and their electrocatalytic response for the detection of glucose in saliva samples were studied. Active surface area and electron transfer performance of CCE/Co-Ni-LDH and CCE/Fe-Ni-LDH were investigated in detail revealing that cobalt is more efficient than iron for intercalation in the LDH structure for electrocatalytic purposes. Based on experimental studies using the chronoamperometry method in the optimized condition, the detection limit, linear range, and sensitivity of the prepared CCE/Co-Ni-LDH for the glucose measurement were found to be 0.104 μM, 0.5–33 μM, and 6.4890 μA μM<sup>−1</sup> cm<sup>−2</sup> respectively, which were remarkably better than CCE/Fe-Ni-LDH. The fastness of the preparation process, renewable surface, and improved analytical performance enabled CCE/Co-Ni-LDH to be a practical sensor for glucose detection in human saliva samples with satisfactory results.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"14 ","pages":"Article 102067"},"PeriodicalIF":2.5,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143155099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-22DOI: 10.1016/j.rechem.2025.102064
Chan Kok Sheng, Nor Azlia Aziz
In the present investigation, nano-CuO catalysts with diverse metamorphic nanostructures, such as sphere-like, sponge-like, and flower-like, were scrutinized through a dropwise precipitation approach followed by annealing at various temperatures and durations. XRD analysis indicates that nano-CuO possesses a monoclinic crystalline phase structure (a = 4.691 Å, b = 3.423 Å, c = 5.145 Å, γ = 90o). The UV–Vis absorbance spectra display an absorption band centered around 450 nm, which becomes stronger as the annealing temperature and duration rise. The FTIR spectra exhibit a prominent infrared band at 515 cm−1 due to the stretching vibration of CuO bonds. Nano-CuO has initiated photoreduction of hazardous rhodamine 6G (R6G) textile effluent under ultraviolet (UV) irradiation. The reaction constant rates comply with pseudo-first-order kinetics, resulting in a 4-fold increase from 1.184 × 10−4 min−1 to 4.408 × 10−4 min−1, with the highest R2 value of ≈ 0.99. The sponge-like porous nanostructure (<100 nm) with reduced bandgap, increased pore dimensions, and improved crystallinity enhances photocatalytic degradation rate and efficiency. The photocatalytic efficiency of current nano-CuO can still be optimized by increasing the optical source power or combining it with other metal-based catalysts for prospective sustainable wastewater remediation.
{"title":"Ultraviolet-induced Photoreduction of rhodamine 6G textile effluent catalyzed by annealed metamorphic Nano-CuO","authors":"Chan Kok Sheng, Nor Azlia Aziz","doi":"10.1016/j.rechem.2025.102064","DOIUrl":"10.1016/j.rechem.2025.102064","url":null,"abstract":"<div><div>In the present investigation, nano-CuO catalysts with diverse metamorphic nanostructures, such as sphere-like, sponge-like, and flower-like, were scrutinized through a dropwise precipitation approach followed by annealing at various temperatures and durations. XRD analysis indicates that nano-CuO possesses a monoclinic crystalline phase structure (<em>a</em> = 4.691 Å, <em>b</em> = 3.423 Å, <em>c</em> = 5.145 Å, γ = 90<sup>o</sup>). The UV–Vis absorbance spectra display an absorption band centered around 450 nm, which becomes stronger as the annealing temperature and duration rise. The FTIR spectra exhibit a prominent infrared band at 515 cm<sup>−1</sup> due to the stretching vibration of Cu<img>O bonds. Nano-CuO has initiated photoreduction of hazardous rhodamine 6G (R6G) textile effluent under ultraviolet (UV) irradiation. The reaction constant rates comply with pseudo-first-order kinetics, resulting in a 4-fold increase from 1.184 × 10<sup>−4</sup> min<sup>−1</sup> to 4.408 × 10<sup>−4</sup> min<sup>−1</sup>, with the highest R<sup>2</sup> value of ≈ 0.99. The sponge-like porous nanostructure (<100 nm) with reduced bandgap, increased pore dimensions, and improved crystallinity enhances photocatalytic degradation rate and efficiency. The photocatalytic efficiency of current nano-CuO can still be optimized by increasing the optical source power or combining it with other metal-based catalysts for prospective sustainable wastewater remediation.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"14 ","pages":"Article 102064"},"PeriodicalIF":2.5,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-22DOI: 10.1016/j.rechem.2025.102065
Amr M. Abdelmoniem , Mostafa E. Salem , Mahmoud Hassan Mohamed Allam , Mortaga M. Abou-Krisha , Ibrahim O. Althobaiti , Said A.S. Ghozlan , Khaled E. Azmy , Ismail A. Abdelhamid
The synthesis of sulfa drugs has received extensive interest from researchers for their broad spectrum of biological activities. In this context, N-Carbamimidoyl-4-((5,5-dimethyl-3-oxocyclohex-1-en-1-yl)amino)benzenesulfonamide 3 was readily prepared and its Michael addition reactions towards activated cinnamonitriles were studied as a route to 4-(2-amino-3-cyano-4-aryl-tetrahydroquinolin-1-yl)-N-carbamimidoylbenzenesulfonamide derivatives 8a-d. Moreover, N-(4-(N-carbamimidoylsulfamoyl)phenyl)-2-cyanoacetamide 13 was prepared and employed as a precursor for the synthesis of 4-(6-amino-3,5-dicyano-2-oxo-4-arylpyridin-1-yl)-N-carbamimidoylbenzenesulfonamide derivatives 17a-e. Green synthesis of the targeted products was done in water in the presence of chitosan as a green catalyst and gave considerably higher yields as compared to conducting reactions in ethanol in presence of non-benign piperidine catalyst. The chemical constitution of all newly synthesized compounds was confirmed by the different spectral tools.
{"title":"Green synthesis of novel hexahydroquinolines and 6-amino-2-oxopyridine-3,5-dicarbonitriles incorporating sulfaguanidine via [3 + 3] atom combination","authors":"Amr M. Abdelmoniem , Mostafa E. Salem , Mahmoud Hassan Mohamed Allam , Mortaga M. Abou-Krisha , Ibrahim O. Althobaiti , Said A.S. Ghozlan , Khaled E. Azmy , Ismail A. Abdelhamid","doi":"10.1016/j.rechem.2025.102065","DOIUrl":"10.1016/j.rechem.2025.102065","url":null,"abstract":"<div><div>The synthesis of sulfa drugs has received extensive interest from researchers for their broad spectrum of biological activities. In this context, <em>N</em>-Carbamimidoyl-4-((5,5-dimethyl-3-oxocyclohex-1-en-1-yl)amino)benzenesulfonamide <strong>3</strong> was readily prepared and its Michael addition reactions towards activated cinnamonitriles were studied as a route to 4-(2-amino-3-cyano-4-aryl-tetrahydroquinolin-1-yl)-<em>N</em>-carbamimidoylbenzenesulfonamide derivatives <strong>8a-d</strong>. Moreover, <em>N</em>-(4-(<em>N</em>-carbamimidoylsulfamoyl)phenyl)-2-cyanoacetamide <strong>13</strong> was prepared and employed as a precursor for the synthesis of 4-(6-amino-3,5-dicyano-2-oxo-4-arylpyridin-1-yl)-<em>N</em>-carbamimidoylbenzenesulfonamide derivatives <strong>17a-e</strong>. Green synthesis of the targeted products was done in water in the presence of chitosan as a green catalyst and gave considerably higher yields as compared to conducting reactions in ethanol in presence of non-benign piperidine catalyst. The chemical constitution of all newly synthesized compounds was confirmed by the different spectral tools.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"14 ","pages":"Article 102065"},"PeriodicalIF":2.5,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143155075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-21DOI: 10.1016/j.rechem.2025.102058
Danjiang Li , Yuanyuan Song , Yuan Zeng , Hua Hu, Wei Tian
Piezo1, a non-selective cation channel, can transduce diverse mechanical stimuli into electrochemical signals and perform essential physiological functions in the human body. Anomalous Piezo1 activities due to loss-of-function mutations are linked to diverse pathological states ranging from anemia, malaria immunity, lymphatic abnormalities, and varicose veins. Thus, targeting and modulating Piezo1 have demonstrated the potential to yield significant therapeutic benefits, thereby affirming Piezo1 as a promising drug target for various diseases. Recent studies have unveiled crystal structures of Piezo1 and identified small-molecule agonists that shed light on the channel’s structure and activation mechanism. This review consolidates our understanding of Piezo1, focusing on its structural features, mechanosensitive activation and potential agonists to guide future investigations in this field.
{"title":"Research progress on PIEZO1 protein structure and activation mechanism by small-molecule agonists","authors":"Danjiang Li , Yuanyuan Song , Yuan Zeng , Hua Hu, Wei Tian","doi":"10.1016/j.rechem.2025.102058","DOIUrl":"10.1016/j.rechem.2025.102058","url":null,"abstract":"<div><div>Piezo1, a non-selective cation channel, can transduce diverse mechanical stimuli into electrochemical signals and perform essential physiological functions in the human body. Anomalous Piezo1 activities due to loss-of-function mutations are linked to diverse pathological states ranging from anemia, malaria immunity, lymphatic abnormalities, and varicose veins. Thus, targeting and modulating Piezo1 have demonstrated the potential to yield significant therapeutic benefits, thereby affirming Piezo1 as a promising drug target for various diseases. Recent studies have unveiled crystal structures of Piezo1 and identified small-molecule agonists that shed light on the channel’s structure and activation mechanism. This review consolidates our understanding of Piezo1, focusing on its structural features, mechanosensitive activation and potential agonists to guide future investigations in this field.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"14 ","pages":"Article 102058"},"PeriodicalIF":2.5,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143155104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Herein, we report a one-pot four-component reaction of two mol of 2-hydroxy-1,4-naphthoquinone, aromatic aldehydes and guanidine in DMF medium at 80 °C for the easy access of aryl-linked hydroxy-naphthoquinone fused with imidazolone and 2-hydroxy-1,4-naphthoquinone moiety. This domino reaction entails Knoevenagel condensation, Michael addition, intramolecular cyclization, and hydrolysis. Catalyst-free reaction, good yields of the products, easy purification process, formation of four new bonds (two C–C and two C–N) in one-pot, and products having two different bioactive moieties are the notable features of this methodology. All the products were fully characterized by IR, 1H NMR, 13C NMR, and CHN analysis.
{"title":"Catalyst-free, one-pot four-component synthesis of aryl-linked hydroxy-naphthoquinone fused with imidazolone and 2-hydroxy-1,4-naphthoquinone moiety: naphtho[1,2-d]imidazolyl(aryl)methylnaphthalene-1,4-diones","authors":"Mohaddeseh Ahmadusefi-Sarhadi, Hossein Mehrabi, Farzaneh Alizadeh-Bami","doi":"10.1016/j.rechem.2025.102057","DOIUrl":"10.1016/j.rechem.2025.102057","url":null,"abstract":"<div><div>Herein, we report a one-pot four-component reaction of two mol of 2-hydroxy-1,4-naphthoquinone, aromatic aldehydes and guanidine in DMF medium at 80 °C for the easy access of aryl-linked hydroxy-naphthoquinone fused with imidazolone and 2-hydroxy-1,4-naphthoquinone moiety. This domino reaction entails Knoevenagel condensation, Michael addition, intramolecular cyclization, and hydrolysis. Catalyst-free reaction, good yields of the products, easy purification process, formation of four new bonds (two C–C and two C–N) in one-pot, and products having two different bioactive moieties are the notable features of this methodology. All the products were fully characterized by IR, <sup>1</sup>H NMR, <sup>13</sup>C NMR, and CHN analysis.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"14 ","pages":"Article 102057"},"PeriodicalIF":2.5,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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