<div><div>The purpose of this study is to investigate the effect of Methyl Red (MR) on the micellization and surface properties of a cationic surfactant, dodecyl trimethylammonium bromide (DTAB), in CH<sub>3</sub>OH–H<sub>2</sub>O mixed solvent systems at varying CH<sub>3</sub>OH parts by volumes (0.1, 0.2, 0.3, and 0.4) and temperatures (298.15 K, 308.15 K and 318.15 K). Surface tension and conductivity measurements were conducted to obtain the critical micelle concentration (CMC) and various surface properties such as premicellar slope (<span><math><mrow><mfrac><mrow><mi>d</mi><mi>γ</mi></mrow><mrow><mi>d</mi><mi>log</mi><mi>C</mi></mrow></mfrac></mrow></math></span>), maximum surface concentration (<span><math><mrow><msub><mi>Γ</mi><mrow><mi>m</mi><mi>a</mi><mi>x</mi></mrow></msub></mrow></math></span>), minimum surface area occupied (<span><math><mrow><msub><mi>π</mi><mrow><mi>C</mi><mi>M</mi><mi>C</mi></mrow></msub></mrow></math></span>), free energy of adsorption (<span><math><mrow><mi>Δ</mi><msubsup><mi>G</mi><mrow><mi>a</mi><mi>d</mi><mi>s</mi></mrow><mi>o</mi></msubsup></mrow></math></span>), adsorption efficiency (<span><math><mrow><mi>p</mi><msub><mi>C</mi><mn>20</mn></msub></mrow></math></span>), packing parameter (<span><math><mrow><mi>P</mi></mrow></math></span>), and aggregation number (<span><math><mrow><msub><mi>N</mi><mrow><mi>agg</mi></mrow></msub></mrow></math></span>). The results indicate that the presence of MR significantly influences the behavior of DTAB in the mixed solvent system. In the absence of MR, the CMC increased with higher CH<sub>3</sub>OH content, while MR reduced the CMC, promoting micelle formation through dye-surfactant-ion-pair (DSIP) formation. Surface properties were enhanced in the presence of MR leading to higher surface pressure. Additionally, the free energy of adsorption (<span><math><mrow><mi>Δ</mi><msubsup><mi>G</mi><mrow><mi>a</mi><mi>d</mi><mi>s</mi></mrow><mi>o</mi></msubsup></mrow></math></span>) became more negative with MR, indicating a more favorable adsorption process. Correlations of (<span><math><mrow><mfrac><mrow><mi>d</mi><mi>γ</mi></mrow><mrow><mi>d</mi><mi>log</mi><mi>C</mi></mrow></mfrac></mrow></math></span>), <span><math><mrow><msub><mi>Γ</mi><mrow><mi>max</mi></mrow></msub><mo>,</mo><msub><mi>γ</mi><mn>0</mn></msub><mo>/</mo><msub><mi>γ</mi><mrow><mi>cmc</mi></mrow></msub></mrow></math></span>, <span><math><mrow><mi>p</mi><msub><mi>C</mi><mn>20</mn></msub></mrow></math></span>, <span><math><mrow><msub><mi>N</mi><mrow><mi>agg</mi></mrow></msub></mrow></math></span>, CMC/C<sub>20</sub> with the parts by volume of CH<sub>3</sub>OH at 298.15 K, 308.15 K, and 318.15 K are discussed with and without MR. The obtained results were used to examine the effect of MR on the surface properties of DTAB in the CH<sub>3</sub>OH–H<sub>2</sub>O medium. The change in properties can be explained in terms of the change in polarity of the medium and dye-surfactant ion pair (DSIP) formation.</div></div
{"title":"Effect of Methyl Red on the surface properties of DTAB in CH3OH–H2O","authors":"Neelam Shahi , Sujit Kumar Shah , Amar Prasad Yadav , Ajaya Bhattarai","doi":"10.1016/j.rechem.2024.101863","DOIUrl":"10.1016/j.rechem.2024.101863","url":null,"abstract":"<div><div>The purpose of this study is to investigate the effect of Methyl Red (MR) on the micellization and surface properties of a cationic surfactant, dodecyl trimethylammonium bromide (DTAB), in CH<sub>3</sub>OH–H<sub>2</sub>O mixed solvent systems at varying CH<sub>3</sub>OH parts by volumes (0.1, 0.2, 0.3, and 0.4) and temperatures (298.15 K, 308.15 K and 318.15 K). Surface tension and conductivity measurements were conducted to obtain the critical micelle concentration (CMC) and various surface properties such as premicellar slope (<span><math><mrow><mfrac><mrow><mi>d</mi><mi>γ</mi></mrow><mrow><mi>d</mi><mi>log</mi><mi>C</mi></mrow></mfrac></mrow></math></span>), maximum surface concentration (<span><math><mrow><msub><mi>Γ</mi><mrow><mi>m</mi><mi>a</mi><mi>x</mi></mrow></msub></mrow></math></span>), minimum surface area occupied (<span><math><mrow><msub><mi>π</mi><mrow><mi>C</mi><mi>M</mi><mi>C</mi></mrow></msub></mrow></math></span>), free energy of adsorption (<span><math><mrow><mi>Δ</mi><msubsup><mi>G</mi><mrow><mi>a</mi><mi>d</mi><mi>s</mi></mrow><mi>o</mi></msubsup></mrow></math></span>), adsorption efficiency (<span><math><mrow><mi>p</mi><msub><mi>C</mi><mn>20</mn></msub></mrow></math></span>), packing parameter (<span><math><mrow><mi>P</mi></mrow></math></span>), and aggregation number (<span><math><mrow><msub><mi>N</mi><mrow><mi>agg</mi></mrow></msub></mrow></math></span>). The results indicate that the presence of MR significantly influences the behavior of DTAB in the mixed solvent system. In the absence of MR, the CMC increased with higher CH<sub>3</sub>OH content, while MR reduced the CMC, promoting micelle formation through dye-surfactant-ion-pair (DSIP) formation. Surface properties were enhanced in the presence of MR leading to higher surface pressure. Additionally, the free energy of adsorption (<span><math><mrow><mi>Δ</mi><msubsup><mi>G</mi><mrow><mi>a</mi><mi>d</mi><mi>s</mi></mrow><mi>o</mi></msubsup></mrow></math></span>) became more negative with MR, indicating a more favorable adsorption process. Correlations of (<span><math><mrow><mfrac><mrow><mi>d</mi><mi>γ</mi></mrow><mrow><mi>d</mi><mi>log</mi><mi>C</mi></mrow></mfrac></mrow></math></span>), <span><math><mrow><msub><mi>Γ</mi><mrow><mi>max</mi></mrow></msub><mo>,</mo><msub><mi>γ</mi><mn>0</mn></msub><mo>/</mo><msub><mi>γ</mi><mrow><mi>cmc</mi></mrow></msub></mrow></math></span>, <span><math><mrow><mi>p</mi><msub><mi>C</mi><mn>20</mn></msub></mrow></math></span>, <span><math><mrow><msub><mi>N</mi><mrow><mi>agg</mi></mrow></msub></mrow></math></span>, CMC/C<sub>20</sub> with the parts by volume of CH<sub>3</sub>OH at 298.15 K, 308.15 K, and 318.15 K are discussed with and without MR. The obtained results were used to examine the effect of MR on the surface properties of DTAB in the CH<sub>3</sub>OH–H<sub>2</sub>O medium. The change in properties can be explained in terms of the change in polarity of the medium and dye-surfactant ion pair (DSIP) formation.</div></div","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"12 ","pages":"Article 101863"},"PeriodicalIF":2.5,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142525903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-16DOI: 10.1016/j.rechem.2024.101865
Abdollah Khorshidi
Background
The radioisotope iodine-125 has been proposed for use in brachytherapy in nuclear medicine. Currently, 125I is mainly produced by neutron irradiation of xenon gas in nuclear reactors, although cyclotron-based production can also be investigated.
Methods
In this research, the cyclotron in Karaj with deuteron energy of 20 MeV and proton energy of 30 MeV was considered to simulate the production of 125I using 124/125Te targets. Here, the 125Te(p,n)125I and 124Te(d,n)125I reactions cross sections were analyzed via TALYS code in optical potential model by changing diffusivity and radius, level density model, density of exciton model constituents, pre-equilibrium and equilibrium model by Hauser-Feshbach formalism, branching rates, and possibility of derived particle generation. Additionally, the cross section of 126Te(p,2n)125I reaction was evaluated besides the cross sections of competing reactions. The production yields of the two types of interactions were calculated at different incident particles energies.
Results
The maximum cross-section data for 125I production via (p,n) reaction was estimated to be 684 mb at 11 MeV and for the (d,n) reaction to be 233 mb at 9 MeV. These reactions gave the 125I production yield of 1.22 and 0.188 MBq/µA.h at these energies, respectively. The calculated cross-sections data for both incident particles energies were plotted and compared with other reports. In curve fitting, the least-square Pade approximation was used with distinct parameters on designated points with χ2 of 0.98 and 0.87 for (d,n) and (p,n) reactions, correspondingly. The maximum uncertainty was estimated to be 6.5 % for 12 MeV deuterons and 12.9 % for 9 MeV protons.
Conclusion
The combination of 125I with other therapeutic radionuclides such as gold and terbium may improve the chances of treatment by increasing the rate of cancer cell killing. Remarkably, the integration of therapy and diagnosis can represent a significant advance in tailored cancer treatment.
{"title":"Appraisal and simulation of 125I production yield with Low/Medium energy proton and deuteron particles on tellurium targets","authors":"Abdollah Khorshidi","doi":"10.1016/j.rechem.2024.101865","DOIUrl":"10.1016/j.rechem.2024.101865","url":null,"abstract":"<div><h3>Background</h3><div>The radioisotope iodine-125 has been proposed for use in brachytherapy in nuclear medicine. Currently, <sup>125</sup>I is mainly produced by neutron irradiation of xenon gas in nuclear reactors, although cyclotron-based production can also be investigated.</div></div><div><h3>Methods</h3><div>In this research, the cyclotron in Karaj with deuteron energy of 20 MeV and proton energy of 30 MeV was considered to simulate the production of <sup>125</sup>I using <sup>124/125</sup>Te targets. Here, the <sup>125</sup>Te(p,n)<sup>125</sup>I and <sup>124</sup>Te(d,n)<sup>125</sup>I reactions cross sections were analyzed via TALYS code in optical potential model by changing diffusivity and radius, level density model, density of exciton model constituents, pre-equilibrium and equilibrium model by Hauser-Feshbach formalism, branching rates, and possibility of derived particle generation. Additionally, the cross section of <sup>126</sup>Te(p,2n)<sup>125</sup>I reaction was evaluated besides the cross sections of competing reactions. The production yields of the two types of interactions were calculated at different incident particles energies.</div></div><div><h3>Results</h3><div>The maximum cross-section data for <sup>125</sup>I production via (p,n) reaction was estimated to be 684 mb at 11 MeV and for the (d,n) reaction to be 233 mb at 9 MeV. These reactions gave the <sup>125</sup>I production yield of 1.22 and 0.188 MBq/µA.h at these energies, respectively. The calculated cross-sections data for both incident particles energies were plotted and compared with other reports. In curve fitting, the least-square Pade approximation was used with distinct parameters on designated points with χ2 of 0.98 and 0.87 for (d,n) and (p,n) reactions, correspondingly. The maximum uncertainty was estimated to be 6.5 % for 12 MeV deuterons and 12.9 % for 9 MeV protons.</div></div><div><h3>Conclusion</h3><div>The combination of <sup>125</sup>I with other therapeutic radionuclides such as gold and terbium may improve the chances of treatment by increasing the rate of cancer cell killing. Remarkably, the integration of therapy and diagnosis can represent a significant advance in tailored cancer treatment.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"12 ","pages":"Article 101865"},"PeriodicalIF":2.5,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142525786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-16DOI: 10.1016/j.rechem.2024.101835
Haider A. Omran , Ahmed A. Majed , Kawkab Hussein , Dawood S. Abid , Mostafa A. Abdel-Maksoud , Ahmed Elwahsh , Mohamed Aufy , Mohamed H. Kotob
In this study, a series of bis amide thiazolidine derivatives (Q1-Q6) were synthesized and their anticancer activity was evaluated against prostate (PC3) and breast (MCF7) cancer cells and normal cells line activity was evaluated against breast (MCF10), prostate (PNT1A) and living human cells (HUVEC) cancer cells. The thiazolidine rings were built from penicillamine and aromatic aldehydes (A1-A6), then converted to acetyl thiazolidines (B1-B6) using acetic anhydride, and finally linked with phenylene diamine to form the final compounds (Q1-Q6). Notably, compounds Q1 and Q3 displayed the highest activity against PC3, with IC50 values of 81 and 89 µg/ml, respectively. Docking simulations were performed for Q1, Q4, and Q5 against protein structures related to cancer (2FVD and 1SJ0). Additionally, DFT calculations were used to determine various molecular properties like HOMO/LUMO energies, band gap, and other descriptors, providing insights into the compounds’ stability and reactivity.
{"title":"Anti-Cancer Activity, DFT and molecular docking study of new BisThiazolidine amide","authors":"Haider A. Omran , Ahmed A. Majed , Kawkab Hussein , Dawood S. Abid , Mostafa A. Abdel-Maksoud , Ahmed Elwahsh , Mohamed Aufy , Mohamed H. Kotob","doi":"10.1016/j.rechem.2024.101835","DOIUrl":"10.1016/j.rechem.2024.101835","url":null,"abstract":"<div><div>In this study, a series of bis amide thiazolidine derivatives (Q1-Q6) were synthesized and their anticancer activity was evaluated against prostate (PC3) and breast (MCF7) cancer cells and normal cells line activity was evaluated against breast (MCF10), prostate (PNT1A) and living human cells (HUVEC) cancer cells. The thiazolidine rings were built from penicillamine and aromatic aldehydes (A1-A6), then converted to acetyl thiazolidines (B1-B6) using acetic anhydride, and finally linked with phenylene diamine to form the final compounds (Q1-Q6). Notably, compounds Q1 and Q3 displayed the highest activity against PC3, with IC50 values of 81 and 89 µg/ml, respectively. Docking simulations were performed for Q1, Q4, and Q5 against protein structures related to cancer (2FVD and 1SJ0). Additionally, DFT calculations were used to determine various molecular properties like HOMO/LUMO energies, band gap, and other descriptors, providing insights into the compounds’ stability and reactivity.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"12 ","pages":"Article 101835"},"PeriodicalIF":2.5,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142525787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-16DOI: 10.1016/j.rechem.2024.101861
Oleksii Y. Kashner, Kyryl O. Bocharov, Gennadii E. Khoroshilov
This study reports the synthesis of a pyridinium salt achieved by heating 2-chloropyridine with 2-bromoacetamide in the absence of solvent. The synthesized salt exhibits a high reactivity towards nucleophilic substitution reactions with C-nucleophiles derived from acetonitrile. Furthermore, the resulting N-carboxamide-2(1H)pyridines are efficiently transformed into 2-amino-3-carboxamideindolizines via a cyclisation process, leading to a high yield of the desired product. These findings highlight the potential of this synthetic route for the production of valuable indolizine derivatives.
{"title":"The synthesis of 2-amino-3-carboxamideindolizines with using pyridinium salt and C-nucleophiles–derivatives acetonitrile","authors":"Oleksii Y. Kashner, Kyryl O. Bocharov, Gennadii E. Khoroshilov","doi":"10.1016/j.rechem.2024.101861","DOIUrl":"10.1016/j.rechem.2024.101861","url":null,"abstract":"<div><div>This study reports the synthesis of a pyridinium salt achieved by heating 2-chloropyridine with 2-bromoacetamide in the absence of solvent. The synthesized salt exhibits a high reactivity towards nucleophilic substitution reactions with C-nucleophiles derived from acetonitrile. Furthermore, the resulting <em>N</em>-carboxamide-2(1H)pyridines are efficiently transformed into 2-amino-3-carboxamideindolizines via a cyclisation process, leading to a high yield of the desired product. These findings highlight the potential of this synthetic route for the production of valuable indolizine derivatives.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"12 ","pages":"Article 101861"},"PeriodicalIF":2.5,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-16DOI: 10.1016/j.rechem.2024.101820
Archana R. Patil , Basappa C. Yallur , Sampath Chinnam , Guddekoppa S. Ananthnag , C.R. Santhosh , Geetika Pant , S.G. Prasanna Kumar , Manjuanth D. Hadagali
Thiazole derivatives have attracted considerable attention in medicinal chemistry due to their promising biological activities. This review article provides a comprehensive overview on the pharmaceutical applications of the thiazole derivatives, exploring their structural activity relationship and medical applications. We discuss the anti-cancer, anti-inflammatory, anti- oxidant, BSA and DNA interaction properties of thiazole derivatives highlighting their role in drug development. This review will be a valuable resource in medicinal chemistry. This could lead to development of drugs containing thiazoles and improve bio-compatibility and efficiency of derivatives.
由于噻唑衍生物具有良好的生物活性，因此在药物化学领域备受关注。这篇综述文章全面概述了噻唑衍生物的药物应用，探讨了它们的结构活性关系和医疗应用。我们讨论了噻唑衍生物的抗癌、抗炎、抗氧化、BSA 和 DNA 相互作用特性，强调了它们在药物开发中的作用。这篇综述将成为药物化学领域的宝贵资源。这将有助于开发含有噻唑的药物，提高衍生物的生物相容性和效率。
{"title":"Pharmaceutical perspectives of thiazole analogues: An overview","authors":"Archana R. Patil , Basappa C. Yallur , Sampath Chinnam , Guddekoppa S. Ananthnag , C.R. Santhosh , Geetika Pant , S.G. Prasanna Kumar , Manjuanth D. Hadagali","doi":"10.1016/j.rechem.2024.101820","DOIUrl":"10.1016/j.rechem.2024.101820","url":null,"abstract":"<div><div>Thiazole derivatives have attracted considerable attention in medicinal chemistry due to their promising biological activities. This review article provides a comprehensive overview on the pharmaceutical applications of the thiazole derivatives, exploring their structural activity relationship and medical applications. We discuss the anti-cancer, anti-inflammatory, anti- oxidant, BSA and DNA interaction properties of thiazole derivatives highlighting their role in drug development. This review will be a valuable resource in medicinal chemistry. This could lead to development of drugs containing thiazoles and improve bio-compatibility and efficiency of derivatives.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"12 ","pages":"Article 101820"},"PeriodicalIF":2.5,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142525783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The sensitive detection of trace amounts of vascular endothelial growth factor (VEGF165) in samples holds significant potential for clinical cancer diagnosis across various cancer types. This work introduces a simple, quick, and economical electrochemical method for exfoliating a graphite paste electrode (CPE) to directly synthesize a reduced graphene oxide nanosheet paste electrode (r-GONPE) for the determination of VEGF165. Thionine (Th) was used as a redox probe due to its strong interaction with the graphene surface. The functionalization of r-GONPE by thionine improves its stability while preserving the intrinsic properties of r-GONPE. Au nanoparticles were electrodeposited on the r-GONPE/Th electrode to stabilize the SH-aptamer by self-assembly for selective interaction and to enhance the speed of electron transfer. FESEM images confirmed the formation of a fixed, stable, very thin, and large few-layer reduced graphene oxide nanosheet on the outer surface of the CPE. The surface area of the bare CPE increased significantly after electrochemical exfoliation of the surface graphite layers (from 0.059 cm2 for CPE to 0.281 cm2 for r-GONPE). Electrical characterization showed that the conversion of graphite to graphene resulted in a five-fold increase in peak height and a decrease in peak separation by nearly 30 mV. The selective interaction of the VEGF165 with the r-GONPE/Th/nano-Au electrode modified with SH-aptamer reduced the oxidation peak current of thionine in the DPV signal. Thus, a wide linear calibration ranges from 5.0 pM to 320 pM and a low LOD of 1.03 pM (using the 3σ/S equation) were obtained. The aptasensor demonstrated consistent stability and strong selectivity against typical interferences when detecting picomolar concentrations of VEGF165. It also showed high accuracy and speed in detecting VEGF165 in human serum samples. Additionally, this aptasensor is advantageous due to its cost-effectiveness and simple fabrication process compared to traditional methods that use complex nanocomposites for signal enhancement.
{"title":"Facile and in situ production of reduced graphene oxide nanosheets paste electrode via electrochemical exfoliation of carbon paste electrode for fabricating a VEGF165 tumor marker aptasensor","authors":"Bahareh Pourbahram , Mojtaba Shamsipur , Samira Mansouri Majd , Leila Samandari","doi":"10.1016/j.rechem.2024.101862","DOIUrl":"10.1016/j.rechem.2024.101862","url":null,"abstract":"<div><div>The sensitive detection of trace amounts of vascular endothelial growth factor (VEGF165) in samples holds significant potential for clinical cancer diagnosis across various cancer types. This work introduces a simple, quick, and economical electrochemical method for exfoliating a graphite paste electrode (CPE) to directly synthesize a reduced graphene oxide nanosheet paste electrode (r-GONPE) for the determination of VEGF165. Thionine (Th) was used as a redox probe due to its strong interaction with the graphene surface. The functionalization of r-GONPE by thionine improves its stability while preserving the intrinsic properties of r-GONPE. Au nanoparticles were electrodeposited on the r-GONPE/Th electrode to stabilize the SH-aptamer by self-assembly for selective interaction and to enhance the speed of electron transfer. FESEM images confirmed the formation of a fixed, stable, very thin, and large few-layer reduced graphene oxide nanosheet on the outer surface of the CPE. The surface area of the bare CPE increased significantly after electrochemical exfoliation of the surface graphite layers (from 0.059 cm<sup>2</sup> for CPE to 0.281 cm<sup>2</sup> for r-GONPE). Electrical characterization showed that the conversion of graphite to graphene resulted in a five-fold increase in peak height and a decrease in peak separation by nearly 30 mV. The selective interaction of the VEGF165 with the r-GONPE/Th/nano-Au electrode modified with SH-aptamer reduced the oxidation peak current of thionine in the DPV signal. Thus, a wide linear calibration ranges from 5.0 pM to 320 pM and a low LOD of 1.03 pM (using the 3σ/S equation) were obtained. The aptasensor demonstrated consistent stability and strong selectivity against typical interferences when detecting picomolar concentrations of VEGF165. It also showed high accuracy and speed in detecting VEGF165 in human serum samples. Additionally, this aptasensor is advantageous due to its cost-effectiveness and simple fabrication process compared to traditional methods that use complex nanocomposites for signal enhancement.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"12 ","pages":"Article 101862"},"PeriodicalIF":2.5,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142525785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-16DOI: 10.1016/j.rechem.2024.101860
Huda Abd-alhamed, Mohammad Keshe, Rasha Alabaas
β-Diketones, also known as 1,3-diketones, hold significant importance in synthetic organic chemistry. This review aims to provide a comprehensive overview of the seven different methods used to prepare 1,3-diketones. and these methods have been described by several researchers. In addition, β-Diketone derivatives have unique physical and chemical properties, as they exist in different tautomeric chemical forms. The most prominent derivatives of 1,3-diketones are highlighted, and the focus is on their diverse applications in various fields.
{"title":"The chemical organic reactions of β-diketones to prepare different β-diketone derivatives, their properties and its applications: A review","authors":"Huda Abd-alhamed, Mohammad Keshe, Rasha Alabaas","doi":"10.1016/j.rechem.2024.101860","DOIUrl":"10.1016/j.rechem.2024.101860","url":null,"abstract":"<div><div>β-Diketones, also known as 1,3-diketones, hold significant importance in synthetic organic chemistry. This review aims to provide a comprehensive overview of the seven different methods used to prepare 1,3-diketones. and these methods have been described by several researchers. In addition, β-Diketone derivatives have unique physical and chemical properties, as they exist in different tautomeric chemical forms. The most prominent derivatives of 1,3-diketones are highlighted, and the focus is on their diverse applications in various fields.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"12 ","pages":"Article 101860"},"PeriodicalIF":2.5,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142525784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-14DOI: 10.1016/j.rechem.2024.101855
E.K. Senbeto , S. Elangovan
Dysprosium-Chromium co-doped bismuth ferrite (Bi0.9Dy0.1Fe1-xCrxO3, x = 0, 0.05, and 0.1) nanoparticles were prepared by the sol–gel technique. The formed gel, held in an evaporating dish, was burned in a hot oven at 210 °C to form fluffy ash. The ground-burnt ash was sintered in a temperature-programmed electric furnace for 5 h at 820°C. The XRD results confirmed that all the prepared samples were in a rhombohedra structure with space group R3c. The XRD analysis revealed that the crystallite size decreased from 19.75 nm to 17.97 nm as the co-dopants increased. The energy dispersive x-ray (EDX) spectroscopy confirmed the presence of the ions as per the stoichiometry ratio. The VSM magnetic measurements revealed that the magnetic parameters, saturation magnetization (Ms), and remnant magnetization (Mr) relatively increased from 1.34 emu/g to 1.63 emu/g, and 0.262 to 0.412, respectively, with increasing the co-dopants, but the coercive field decreased. The UV–Vis measurement showed that the energy band gap (Eg) increased from 1.93 eV to 2.15 eV as the concentration of the co-dopants increased from x = 0 to x = 0.10.
{"title":"Structural, optical, and magnetic properties study of Dy-Cr co-doped bismuth ferrite (BFO) nanoparticles","authors":"E.K. Senbeto , S. Elangovan","doi":"10.1016/j.rechem.2024.101855","DOIUrl":"10.1016/j.rechem.2024.101855","url":null,"abstract":"<div><div>Dysprosium-Chromium co-doped bismuth ferrite (Bi<sub>0.9</sub>Dy<sub>0.1</sub>Fe<sub>1-x</sub>Cr<sub>x</sub>O<sub>3,</sub> x = 0, 0.05, and 0.1) nanoparticles were prepared by the sol–gel technique. The formed gel, held in an evaporating dish, was burned in a hot oven at 210 °C to form fluffy ash. The ground-burnt ash was sintered in a temperature-programmed electric furnace for 5 h at 820°C. The XRD results confirmed that all the prepared samples were in a rhombohedra structure with space group R3c. The XRD analysis revealed that the crystallite size decreased from 19.75 nm to 17.97 nm as the co-dopants increased. The energy dispersive x-ray (EDX) spectroscopy confirmed the presence of the ions as per the stoichiometry ratio. The VSM magnetic measurements revealed that the magnetic parameters, saturation magnetization (Ms), and remnant magnetization (Mr) relatively increased from 1.34 emu/g to 1.63 emu/g, and 0.262 to 0.412, respectively, with increasing the co-dopants, but the coercive field decreased. The UV–Vis measurement showed that the energy band gap (Eg) increased from 1.93 eV to 2.15 eV as the concentration of the co-dopants increased from x = 0 to x = 0.10.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"12 ","pages":"Article 101855"},"PeriodicalIF":2.5,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-14DOI: 10.1016/j.rechem.2024.101859
Mohsin Omar Mohammed , Hameed Madlool Mohammed Alkubaisi , Nadia Qader Haj
Chitosan (CS) a chemical substance taken from the shells of sea creatures that has various uses in industry, farming, and medicine, for example in medical dressings. Its derivatives significantly inhibit two types of cancer cells: Madin Darby Canine Kidney MDCK and MCF-7. These derivatives include thiosemicarbazones, heterocyclic moieties, and their metal (II) complexes. In this study, CS from crab shells is mixed with thiosemicarbazide (TSC). Then, imidazole-2-carboxaldehyde, oxazole-2-carboxaldehyde, and thiazole-2-carboxaldehyde reacted to make three different compounds from CS-TSC: [2a], [2b], and [2c]. The chemicals were mixed with nickel chloride to create nickel (II) chitosan 2-acetyl heterocyclic-2-thiosemicarbazone complexes. SEM and X-ray tests were performed on the powder, which showed that the nickel (II) chitosan thiosemicarbazone complexes had square and flat shapes. The synthesized compounds were tested to check their effectiveness in preventing MDCK and MCF-7. The study found that chitosan derivatives significantly inhibited MDCK and MCF-7.
{"title":"Synthesis, Identification, and anti-cancer Evaluation of Some heterocyclic Chitosan-Thiosemicarbazones compounds and their nickle (II) complexes","authors":"Mohsin Omar Mohammed , Hameed Madlool Mohammed Alkubaisi , Nadia Qader Haj","doi":"10.1016/j.rechem.2024.101859","DOIUrl":"10.1016/j.rechem.2024.101859","url":null,"abstract":"<div><div>Chitosan (CS) a chemical substance taken from the shells of sea creatures that has various uses in industry, farming, and medicine, for example in medical dressings. Its derivatives significantly inhibit two types of cancer cells: Madin Darby Canine Kidney MDCK and MCF-7. These derivatives include thiosemicarbazones, heterocyclic moieties, and their metal (II) complexes. In this study, CS from crab shells is mixed with thiosemicarbazide (TSC). Then, imidazole-2-carboxaldehyde, oxazole-2-carboxaldehyde, and thiazole-2-carboxaldehyde reacted to make three different compounds from CS-TSC: [<strong>2a</strong>], [<strong>2b</strong>], and [<strong>2c</strong>]. The chemicals were mixed with nickel chloride to create nickel (II) chitosan 2-acetyl heterocyclic-2-thiosemicarbazone complexes. SEM and X-ray tests were performed on the powder, which showed that the nickel (II) chitosan thiosemicarbazone complexes had square and flat shapes. The synthesized compounds were tested to check their effectiveness in preventing MDCK and MCF-7. The study found that chitosan derivatives significantly inhibited MDCK and MCF-7.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"12 ","pages":"Article 101859"},"PeriodicalIF":2.5,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nanoparticles may be synthesized through chemical, physical, and biological strategies, but the former strategies contain critical troubles, including environmental toxicity and cost-effectiveness. This work addresses adopting a green synthesis method for ZnO NPs using Rumex abyssinicus Jacq root extract for antibacterial and antioxidant programs. A UV–vis spectrophotometer optimized various factors, including temperature, pH, time, zinc acetate dihydrate attention, and the volume ratio of zinc acetate dihydrate to plant root extract. The biosynthesized ZnO NPs had been examined using exclusive characterization instrunments. ZnO NPs and Rumex abyssinicus Jacq root extract confirmed enormous inhibitory effects on pathogenic bacterial lines, inclusive of the gram-negative bacterial strains Escherichia coli and Staphylococcus typhi and the gram-positive bacterial pressure Staphylococcus aureus. ZnO NPs and Rumex abyssinicus Jacq root extract exhibited the best antioxidant sports. consequently, this has a look at confirmed that Rumex abyssinicus Jacq root extract is an effective decreasing agent for the synthesis of ZnO NPs, which exhibit antibacterial and antioxidant activities.
{"title":"Biogenic Synthesis, Optimization, and characterization of zinc oxide nanoparticles using Rumex abyssinicus Jacq root extract for antioxidant and antibacterial activities","authors":"Amogne Wendu Digisu , Abrha Berhe Yaebyo , Worku Lakew Kebede , Dawit Yirga Kebede , Desilal Kokebie Molla","doi":"10.1016/j.rechem.2024.101857","DOIUrl":"10.1016/j.rechem.2024.101857","url":null,"abstract":"<div><div>Nanoparticles may be synthesized through chemical, physical, and biological strategies, but the former strategies contain critical troubles, including environmental toxicity and cost-effectiveness. This work addresses adopting a green synthesis method for ZnO NPs using <em>Rumex abyssinicus Jacq</em> root extract for antibacterial and antioxidant programs. A UV–vis spectrophotometer optimized various factors, including temperature, pH, time, zinc acetate dihydrate attention, and the volume ratio of zinc acetate dihydrate to plant root extract. The biosynthesized ZnO NPs had been examined using exclusive characterization instrunments. ZnO NPs and <em>Rumex abyssinicus Jacq</em> root extract confirmed enormous inhibitory effects on pathogenic bacterial lines, inclusive of the gram-negative bacterial strains <em>Escherichia coli</em> and <em>Staphylococcus typhi</em> and the gram-positive bacterial pressure <em>Staphylococcus aureus</em>. ZnO NPs and <em>Rumex abyssinicus Jacq</em> root extract exhibited the best antioxidant sports. consequently, this has a look at confirmed that <em>Rumex abyssinicus Jacq</em> root extract is an effective decreasing agent for the synthesis of ZnO NPs, which exhibit antibacterial and antioxidant activities.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"12 ","pages":"Article 101857"},"PeriodicalIF":2.5,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142539288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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