Results in Chemistry最新文献

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Evaluation the biological effect of niosomal hydrogel base amphotericin in combination with Artemisia sieberi essential oil for treatment of cutaneous leishmaniasis: In vitro and in vivo studies

IF 2.5 Q2 CHEMISTRY, MULTIDISCIPLINARY

Results in Chemistry

Pub Date : 2025-03-08 DOI: 10.1016/j.rechem.2025.102185

Hanieh Ardeshiri , Amir Hossein Radfar , Gholamreza Hatam , Mohammad Saleh Bahreini , Negar Azarpira , Shreeshivadasan Chelliapan , Hesam Kamyab , Seyed Reza Kasaee , Ali Mohammad Amani , Sareh Mosleh-Shirazi

Leishmania is an obligate intracellular parasite that is endemic in many countries. It has two main subtypes of cutaneous leishmaniasis (CL) and visceral leishmaniasis (VL). The cutaneous type is non-fatal, but immediate treatment is essential to prevent annoying cosmetic outcomes and financial burdens for patients. The current treatments for cutaneous leishmaniasis (CL) are expensive, with many side effects and indeterminate outcomes. The aim of this study was to investigate the potential of Amphotericin B (AmB) niosomal hydrogel, alone and in combination with Artemisia sieberi essential oil (ASEO), as a treatment for cutaneous leishmaniasis. Niosomes were prepared by the thin-film hydration method. The results showed that the average size of AmB, ASEO, and AmB + ASEO niosomes were 80, 92, and 104 nm, respectively. The results revealed the excellent amount of drug loading for these products. In vitro studies indicated that the lethal effects of AmB, ASEO, and AmB + ASEO were 87.14, 85.31 and 89.73 %, respectively. MTT assay was applied to evaluate the cytotoxicity of various concentrations of products. The in vivo results on BALB/c mice revealed a significant reduction in lesion size in the AmB hydrogel niosomal and AmB + ASEO hydrogel niosomal. In conclusion, the results suggest that hydrogel niosomal AmB and AmB + ASEO could be considered as the novel and effective treatments for CL.

{"title":"Evaluation the biological effect of niosomal hydrogel base amphotericin in combination with Artemisia sieberi essential oil for treatment of cutaneous leishmaniasis: In vitro and in vivo studies","authors":"Hanieh Ardeshiri , Amir Hossein Radfar , Gholamreza Hatam , Mohammad Saleh Bahreini , Negar Azarpira , Shreeshivadasan Chelliapan , Hesam Kamyab , Seyed Reza Kasaee , Ali Mohammad Amani , Sareh Mosleh-Shirazi","doi":"10.1016/j.rechem.2025.102185","DOIUrl":"10.1016/j.rechem.2025.102185","url":null,"abstract":"<div><div>Leishmania is an obligate intracellular parasite that is endemic in many countries. It has two main subtypes of cutaneous leishmaniasis (CL) and visceral leishmaniasis (VL). The cutaneous type is non-fatal, but immediate treatment is essential to prevent annoying cosmetic outcomes and financial burdens for patients. The current treatments for cutaneous leishmaniasis (CL) are expensive, with many side effects and indeterminate outcomes. The aim of this study was to investigate the potential of Amphotericin B (AmB) niosomal hydrogel, alone and in combination with <em>Artemisia sieberi</em> essential oil (ASEO), as a treatment for cutaneous leishmaniasis. Niosomes were prepared by the thin-film hydration method. The results showed that the average size of AmB, ASEO, and AmB + ASEO niosomes were 80, 92, and 104 nm, respectively. The results revealed the excellent amount of drug loading for these products. In vitro studies indicated that the lethal effects of AmB, ASEO, and AmB + ASEO were 87.14, 85.31 and 89.73 %, respectively. MTT assay was applied to evaluate the cytotoxicity of various concentrations of products. The in vivo results on BALB/c mice revealed a significant reduction in lesion size in the AmB hydrogel niosomal and AmB + ASEO hydrogel niosomal. In conclusion, the results suggest that hydrogel niosomal AmB and AmB + ASEO could be considered as the novel and effective treatments for CL.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"15 ","pages":"Article 102185"},"PeriodicalIF":2.5,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143600376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spectrophotometric method for detecting lead (II) ions using a chemosensor of the thiosemicarbazone-linked phenyl sulphone moiety

IF 2.5 Q2 CHEMISTRY, MULTIDISCIPLINARY

Results in Chemistry

Pub Date : 2025-03-08 DOI: 10.1016/j.rechem.2025.102174

Gharam I. Mohammed , Sulafa Nassar , Thoraya A. Farghaly

For the spectrophotometric determination of lead, a novel, straightforward, and sensitive technique has been described. In an alkaline media (pH 12), lead)II (forms a yellow chelate with 2-(1-(4-methoxyphenyl)-2-(phenylsulfonyl)ethylidene)-hydrazine-1-carbothioamide. The complex's molar absorptivity at 257 nm (λ_max) is 1.6 × 10³ L mol⁻¹ cm⁻¹, and its quantification and detection limits are 3.04 μg mL⁻¹ (15 μmol L⁻¹) and 1.25 μg mL⁻¹ (6.03 μmol L⁻¹), respectively. In the concentration range of (2.4–12) × 10⁻⁵ mol L⁻¹, Beer's law is followed. The technique has also been used for Pb recovery investigations in water samples. The molar ratio, which was 1:1 (L: Pb²⁺), guaranteed that a metal complex would form between the L and Pb ions. Simple, inexpensive, easy to use, rapid detection, and sensitivity are only a few advantages of the employed technique. The isolation and study of the solid complex (L-Pb) has provided more insight into the structure and stoichiometry of the complex that forms in solution between Pb(II) and L ligand. By using analytical methods such elemental analysis, spectral mass, UV–Vis spectra, and thermal analysis, the structure of the solid complex has been clarified.

{"title":"Spectrophotometric method for detecting lead (II) ions using a chemosensor of the thiosemicarbazone-linked phenyl sulphone moiety","authors":"Gharam I. Mohammed , Sulafa Nassar , Thoraya A. Farghaly","doi":"10.1016/j.rechem.2025.102174","DOIUrl":"10.1016/j.rechem.2025.102174","url":null,"abstract":"<div><div>For the spectrophotometric determination of lead, a novel, straightforward, and sensitive technique has been described. In an alkaline media (pH 12), lead)II (forms a yellow chelate with 2-(1-(4-methoxyphenyl)-2-(phenylsulfonyl)ethylidene)-hydrazine-1-carbothioamide. The complex's molar absorptivity at 257 nm (λ<sub>max</sub>) is 1.6 × 10<sup>3</sup> L mol<sup>−1</sup> cm<sup>−1</sup>, and its quantification and detection limits are 3.04 μg mL<sup>−1</sup> (15 μmol L<sup>−1</sup>) and 1.25 μg mL<sup>−1</sup> (6.03 μmol L<sup>−1</sup>), respectively. In the concentration range of (2.4–12) × 10<sup>−5</sup> mol L<sup>−1</sup>, Beer's law is followed. The technique has also been used for Pb recovery investigations in water samples. The molar ratio, which was 1:1 (L: Pb<sup>2+</sup>), guaranteed that a metal complex would form between the L and Pb ions. Simple, inexpensive, easy to use, rapid detection, and sensitivity are only a few advantages of the employed technique. The isolation and study of the solid complex (L-Pb) has provided more insight into the structure and stoichiometry of the complex that forms in solution between Pb(II) and L ligand. By using analytical methods such elemental analysis, spectral mass, UV–Vis spectra, and thermal analysis, the structure of the solid complex has been clarified.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"15 ","pages":"Article 102174"},"PeriodicalIF":2.5,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143593117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of parameter variation on the coordination of 5-amino benzene-1, 3-dicarboxylic acid under the solvothermal technique for catalytic adsorption

IF 2.5 Q2 CHEMISTRY, MULTIDISCIPLINARY

Results in Chemistry

Pub Date : 2025-03-07 DOI: 10.1016/j.rechem.2025.102169

Aba Akebi Atta-Eyison , Ruphino Zugle

The solvothermal synthesis of metal-organic frameworks (MOFs) has shown to be very effective for the formation of well-crystalline MOFs due to the presence of polar organic solvents to aid solute solubility under high temperatures and pressure. 5-Aminobenzene-1, 3-dicarboxylic acid as a linker for the synthesis of metal-organic frameworks has been identified to have rich coordination properties due to the presence of carboxylic and amino groups in its structure. In this study, two metal-organic frameworks were synthesized using 5-Aminobenzene-1, 3-dicarboxylic acid and copper (II) nitrate trihydrate under two different conditions using the solvothermal technique. The MOFs were characterized to assess the diversity in their structural formation. Characterization confirmed different MOFs, Cu-5abdc and Cu-5abdc-NH₂ formed based on the evaluation of their functional group and bond formations, crystalline phases, morphology as well as thermal stability. The presence of double peaks with bands at 3243 cm⁻¹ and 3120 cm⁻¹ indicated the presence of the primary amine (NH₂) group in Cu-5abdc-NH₂. Both MOFs had some similar crystalline peaks which matched copper oxide (CuO) crystal and other different peak patterns. The MOFs were both stable and could only decompose above 200 °C. However, Cu-5abdc-NH₂ was observed to be more stable in comparison with Cu-5abdc due to a broad study decomposition observed. The Cu-5abdc-NH₂ also showed a more catalytic adsorption activity for the conversion and removal of Hillanthine B. The pseudo-second-order kinetic reaction rate favoured the adsorption of HB by the MOFs. The adsorption of HB on Cu-5abdc and Cu-5abdc-NH₂ both fit the Freundlich model better than the Langmuir model due to the R² values observed.

{"title":"Effect of parameter variation on the coordination of 5-amino benzene-1, 3-dicarboxylic acid under the solvothermal technique for catalytic adsorption","authors":"Aba Akebi Atta-Eyison , Ruphino Zugle","doi":"10.1016/j.rechem.2025.102169","DOIUrl":"10.1016/j.rechem.2025.102169","url":null,"abstract":"<div><div>The solvothermal synthesis of metal-organic frameworks (MOFs) has shown to be very effective for the formation of well-crystalline MOFs due to the presence of polar organic solvents to aid solute solubility under high temperatures and pressure. 5-Aminobenzene-1, 3-dicarboxylic acid as a linker for the synthesis of metal-organic frameworks has been identified to have rich coordination properties due to the presence of carboxylic and amino groups in its structure. In this study, two metal-organic frameworks were synthesized using 5-Aminobenzene-1, 3-dicarboxylic acid and copper (II) nitrate trihydrate under two different conditions using the solvothermal technique. The MOFs were characterized to assess the diversity in their structural formation. Characterization confirmed different MOFs, Cu-5abdc and Cu-5abdc-NH<sub>2</sub> formed based on the evaluation of their functional group and bond formations, crystalline phases, morphology as well as thermal stability. The presence of double peaks with bands at 3243 cm<sup>−1</sup> and 3120 cm<sup>−1</sup> indicated the presence of the primary amine (NH<sub>2</sub>) group in Cu-5abdc-NH<sub>2</sub>. Both MOFs had some similar crystalline peaks which matched copper oxide (CuO) crystal and other different peak patterns. The MOFs were both stable and could only decompose above 200 °C. However, Cu-5abdc-NH<sub>2</sub> was observed to be more stable in comparison with Cu-5abdc due to a broad study decomposition observed. The Cu-5abdc-NH<sub>2</sub> also showed a more catalytic adsorption activity for the conversion and removal of Hillanthine B. The pseudo-second-order kinetic reaction rate favoured the adsorption of HB by the MOFs. The adsorption of HB on Cu-5abdc and Cu-5abdc-NH<sub>2</sub> both fit the Freundlich model better than the Langmuir model due to the R<sup>2</sup> values observed.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"15 ","pages":"Article 102169"},"PeriodicalIF":2.5,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143593118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alginate/magnetic hydroxyapatite bio-nanocomposite hydrogel bead as a pH-responsive oral drug carrier for potential colon cancer therapy 藻酸盐/磁性羟基磷灰石生物纳米复合材料水凝胶珠作为 pH 值响应型口服药物载体，用于潜在的结肠癌治疗

IF 2.5 Q2 CHEMISTRY, MULTIDISCIPLINARY

Results in Chemistry

Pub Date : 2025-03-07 DOI: 10.1016/j.rechem.2025.102177

Rauf Foroutan , Ali Mohammadzadeh , Siamak Javanbakht , Reza Mohammadi , Marjan Ghorbani

In this study, a biocompatible pH-sensitive magnetic nanocomposite hydrogel bead was developed as a potential oral drug carrier. Fe₃O₄ nanoparticles (NPs) were in situ synthesized in the presence of hydroxyapatite (HAp) NPs as substrate and the HAp-Fe₃O₄ nanohybrid was then incorporated into the pH-sensitive sodium alginate (SA) biopolymer. Ultimately, 5-Fluorouracil (5-FU) as an anticancer drug was successfully loaded in the SA/HAp-Fe₃O₄. The SA/HAp-Fe₃O₄ hydrogel bead shows minimal swelling in acidic environments (pH 1.2) and significant swelling in alkaline environments (pH 7.4). Additionally, drug release studies demonstrated that this drug delivery system was able to retain the drug in the acidic stomach environment and release it in the higher pH of the intestine. Kinetic analysis of the release profiles indicated that the release rate was primarily controlled by Fickian diffusion, which is a process governed by diffusion without interaction between the polymer matrix and the drug. The cytotoxicity results investigated by the MTT assay indicated good cytocompatibility for the SA/HAp/Fe₃O₄ magnetic nanocomposite hydrogel bead, with cell viability exceeding 85 % in 4 to 48 μg/mL (P < 0.05); however, 5-FU-loaded SA/HAp-Fe₃O₄ showed noticeable toxicity against HT-29 human colon cancer cells. Based on the pH-sensitivity, controlled release, and cytotoxicity data, the prepared magnetic nanocomposite hydrogel bead could serve as a targeted oral drug delivery system for colon cancer therapy.

{"title":"Alginate/magnetic hydroxyapatite bio-nanocomposite hydrogel bead as a pH-responsive oral drug carrier for potential colon cancer therapy","authors":"Rauf Foroutan , Ali Mohammadzadeh , Siamak Javanbakht , Reza Mohammadi , Marjan Ghorbani","doi":"10.1016/j.rechem.2025.102177","DOIUrl":"10.1016/j.rechem.2025.102177","url":null,"abstract":"<div><div>In this study, a biocompatible pH-sensitive magnetic nanocomposite hydrogel bead was developed as a potential oral drug carrier. Fe<sub>3</sub>O<sub>4</sub> nanoparticles (NPs) were in situ synthesized in the presence of hydroxyapatite (HAp) NPs as substrate and the HAp-Fe<sub>3</sub>O<sub>4</sub> nanohybrid was then incorporated into the pH-sensitive sodium alginate (SA) biopolymer. Ultimately, 5-Fluorouracil (5-FU) as an anticancer drug was successfully loaded in the SA/HAp-Fe<sub>3</sub>O<sub>4</sub>. The SA/HAp-Fe<sub>3</sub>O<sub>4</sub> hydrogel bead shows minimal swelling in acidic environments (pH 1.2) and significant swelling in alkaline environments (pH 7.4). Additionally, drug release studies demonstrated that this drug delivery system was able to retain the drug in the acidic stomach environment and release it in the higher pH of the intestine. Kinetic analysis of the release profiles indicated that the release rate was primarily controlled by Fickian diffusion, which is a process governed by diffusion without interaction between the polymer matrix and the drug. The cytotoxicity results investigated by the MTT assay indicated good cytocompatibility for the SA/HAp/Fe<sub>3</sub>O<sub>4</sub> magnetic nanocomposite hydrogel bead, with cell viability exceeding 85 % in 4 to 48 μg/mL (<em>P</em> < 0.05); however, 5-FU-loaded SA/HAp-Fe<sub>3</sub>O<sub>4</sub> showed noticeable toxicity against HT-29 human colon cancer cells. Based on the pH-sensitivity, controlled release, and cytotoxicity data, the prepared magnetic nanocomposite hydrogel bead could serve as a targeted oral drug delivery system for colon cancer therapy.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"15 ","pages":"Article 102177"},"PeriodicalIF":2.5,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143628776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pd nanoparticles and anionic Pd catalyst: Potent catalyst for Heck reaction

IF 2.5 Q2 CHEMISTRY, MULTIDISCIPLINARY

Results in Chemistry

Pub Date : 2025-03-07 DOI: 10.1016/j.rechem.2025.102173

Yavar Ahmadi , Sima Majidi

One of the paramount techniques in the arsenal of organic synthesis is catalysis involving palladium derivatives. Regardless of whether researchers intentionally design Pd nanoparticles, these structures can function as key precatalysts in the creation of common CC bonds. Additionally, recent research has demonstrated that anionic Pd complexes serve as effective catalysts for various catalytic cross-coupling reactions. Considering the importance of palladium nanoparticles and anionic palladium catalysts in the creation of CC bonds, in this review we have discussed the latest research on the use of palladium nanoparticles catalysts coupled with chitosan, pectin, chitin, MOFs, carbon nanotubes, Fe₃O₄, and Pd NPs based on complex as well as anionic Pd catalysts in the Heck reaction.

钯衍生物催化技术是有机合成领域最重要的技术之一。无论研究人员是否有意设计钯纳米粒子，这些结构都能在生成普通 CC 键时起到关键的前催化剂作用。此外，最近的研究表明，阴离子钯配合物是各种催化交叉偶联反应的有效催化剂。考虑到钯纳米粒子和阴离子钯催化剂在生成 CC 键中的重要性，我们在本综述中讨论了在 Heck 反应中使用钯纳米粒子催化剂与壳聚糖、果胶、甲壳素、MOFs、碳纳米管、Fe3O4 和基于钯纳米粒子的络合物以及阴离子钯催化剂的最新研究。

引用次数: 0

Exploring antidiabetic potential of Nigella sativa and Silybum marianum seed extracts through bioassay-guided alpha-amylase inhibition activity and characterization of bioactive fractions

IF 2.5 Q2 CHEMISTRY, MULTIDISCIPLINARY

Results in Chemistry

Pub Date : 2025-03-07 DOI: 10.1016/j.rechem.2025.102183

Kainat Nasir , Syeda Laila Rubab , Hina Fatima , Farzana Shamim , Abdul Tawab , Iqra Arshad , Riffat Iqbal , Sofia Parveen , Mubshara Saadia , Bakar Bin Khatab Abbasi , Ali Irfan , Mohammad Raish , Yousef A. Bin Jardan

Diabetes mellitus is a global health threat, and natural remedies are gaining attention due to the severe side effects of synthetic drugs. The current study explores the antidiabetic potential of individual seed extracts and their combination prepared from Nigella sativa and Silybum marianum plants through a bioassay-guided study using alpha-amylase. The characterized column fraction F5 isolated from an herbal combination of N. sativa and S. marianum seed extracts showed the highest alpha-amylase inhibition activity (79.54 %) than the fractions of individual extracts, N. sativa fraction F7 (66.83 %) and S. marianum fraction F4 (68.87 %) in comparison with standard drug acarbose (78.65 %). The fractions with the highest percent inhibition activity were analyzed through FTIR, indicating the existence of different functional groups corresponding to diversity of bioactive compounds in fractions F5, F7, and F4. However, the highest number of peaks were noted in the F5 fraction (from combined extract). The isolated fraction F5 exhibited significant antidiabetic potential due to the presence of important phytochemicals, including mostly fatty acids, some phenolic compounds, steroids, alkaloids, vitamins, and organic acids, which may be manipulated for the development of some herbal drugs to safely manage diabetes in future studies after in-vivo and clinical trials.

{"title":"Exploring antidiabetic potential of Nigella sativa and Silybum marianum seed extracts through bioassay-guided alpha-amylase inhibition activity and characterization of bioactive fractions","authors":"Kainat Nasir , Syeda Laila Rubab , Hina Fatima , Farzana Shamim , Abdul Tawab , Iqra Arshad , Riffat Iqbal , Sofia Parveen , Mubshara Saadia , Bakar Bin Khatab Abbasi , Ali Irfan , Mohammad Raish , Yousef A. Bin Jardan","doi":"10.1016/j.rechem.2025.102183","DOIUrl":"10.1016/j.rechem.2025.102183","url":null,"abstract":"<div><div>Diabetes mellitus is a global health threat, and natural remedies are gaining attention due to the severe side effects of synthetic drugs. The current study explores the antidiabetic potential of individual seed extracts and their combination prepared from <em>Nigella sativa</em> and <em>Silybum marianum</em> plants through a bioassay-guided study using alpha-amylase. The characterized column fraction F5 isolated from an herbal combination of <em>N. sativa</em> and <em>S. marianum</em> seed extracts showed the highest alpha-amylase inhibition activity (79.54 %) than the fractions of individual extracts, <em>N. sativa</em> fraction F7 (66.83 %) and <em>S. marianum</em> fraction F4 (68.87 %) in comparison with standard drug acarbose (78.65 %). The fractions with the highest percent inhibition activity were analyzed through FTIR, indicating the existence of different functional groups corresponding to diversity of bioactive compounds in fractions F5, F7, and F4. However, the highest number of peaks were noted in the F5 fraction (from combined extract). The isolated fraction F5 exhibited significant antidiabetic potential due to the presence of important phytochemicals, including mostly fatty acids, some phenolic compounds, steroids, alkaloids, vitamins, and organic acids, which may be manipulated for the development of some herbal drugs to safely manage diabetes in future studies after <em>in-vivo</em> and clinical trials.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"15 ","pages":"Article 102183"},"PeriodicalIF":2.5,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143600387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of porous volcanic tuff-based geopolymer for nickel and cobalt removal

IF 2.5 Q2 CHEMISTRY, MULTIDISCIPLINARY

Results in Chemistry

Pub Date : 2025-03-07 DOI: 10.1016/j.rechem.2025.102179

Faris Matalkah , Marwa Bani Hani , Idrees Al-Momani

This study investigates the synthesis and application of porous volcanic tuff-based geopolymers for the efficient removal of Ni²⁺ and Co²⁺ ions from aqueous solutions. The geopolymer was prepared using volcanic tuff as the primary aluminosilicate source, activated with sodium hydroxide, and foamed with hydrogen peroxide to enhance porosity. The synthesized geopolymer was characterized using SEM and XRD. Batch adsorption studies were conducted to assess the effects of pH, contact time, initial metal concentration, and geopolymer dose on removal efficiency. Results indicated that the geopolymer exhibited superior adsorption capacity compared to raw volcanic tuff, with maximum removal efficiencies of 86.72 % for Co²⁺ and 81.27 % for Ni²⁺ at optimal conditions (pH 6, 180 min contact time). Adsorption data were best fitted to the Langmuir isotherm model, indicating monolayer adsorption on a homogeneous surface, with maximum adsorption capacities of 3.19 mg/g for Ni²⁺ and 2.40 mg/g for Co²⁺. The thermodynamic parameters ΔG°, ΔH°, and ΔS° suggest that the geopolymer adsorption is favorable, and the process is endothermic and significantly more effective at higher temperatures.

{"title":"Synthesis of porous volcanic tuff-based geopolymer for nickel and cobalt removal","authors":"Faris Matalkah , Marwa Bani Hani , Idrees Al-Momani","doi":"10.1016/j.rechem.2025.102179","DOIUrl":"10.1016/j.rechem.2025.102179","url":null,"abstract":"<div><div>This study investigates the synthesis and application of porous volcanic tuff-based geopolymers for the efficient removal of Ni<sup>2+</sup> and Co<sup>2+</sup> ions from aqueous solutions. The geopolymer was prepared using volcanic tuff as the primary aluminosilicate source, activated with sodium hydroxide, and foamed with hydrogen peroxide to enhance porosity. The synthesized geopolymer was characterized using SEM and XRD. Batch adsorption studies were conducted to assess the effects of pH, contact time, initial metal concentration, and geopolymer dose on removal efficiency. Results indicated that the geopolymer exhibited superior adsorption capacity compared to raw volcanic tuff, with maximum removal efficiencies of 86.72 % for Co<sup>2+</sup> and 81.27 % for Ni<sup>2+</sup> at optimal conditions (pH 6, 180 min contact time). Adsorption data were best fitted to the Langmuir isotherm model, indicating monolayer adsorption on a homogeneous surface, with maximum adsorption capacities of 3.19 mg/g for Ni<sup>2+</sup> and 2.40 mg/g for Co<sup>2+</sup>. The thermodynamic parameters ΔG°, ΔH°, and ΔS° suggest that the geopolymer adsorption is favorable, and the process is endothermic and significantly more effective at higher temperatures.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"15 ","pages":"Article 102179"},"PeriodicalIF":2.5,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143620210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, characterization and in-vitro study of hydroxyapatite, silver substituted hydroxyapatite and iron substituted hydroxyapatite for bone tissue engineering applications

IF 2.5 Q2 CHEMISTRY, MULTIDISCIPLINARY

Results in Chemistry

Pub Date : 2025-03-06 DOI: 10.1016/j.rechem.2025.102167

Sonia Sharma , Parveen Goyal

Calcium phosphate-based biomaterials resemble the inorganic composition of bone, they have attracted attention for bone tissue engineering applications. These compositions tend to develop an interface with the target bone because they are bioactive, bioresorbable, and biocompatible. Hydroxyapatite (HA) has gained importance among calcium phosphates because of its orthopaedic and dental applications.The ability of hydroxyapatite to exchange ions in the lattice framework allows the substitution of different ions to improve the resorbability of the ceramics. This study used a water-based sol-gel approach to create nano-dimensional HA and substituted (with ions Ag⁺ and Fe²⁺) nanopowders. X-ray florescence spectroscopy (XRF) was used for the compositional study, and X-ray diffraction (XRD) was used to ascertain the lattice parameters, phase transitions, purity, and crystallinity. FTIR, Fourier Transform Infrared Spectroscopy, was used to identify the functional groups. In-vitro study was performed by immersing the nanopowders at 37 °C in SBF for 30 days. The crystallinity of the nanopowders increased as the calcination temperature increased from 800 °C to 1200 °C. The crystallinnity of the calcined HA, Ag-HA, and Fe-HA, was found to be in the range of 85–98 %, 77–89 %, and 83–89 %, respectively. The mean crystallite size of the as-synthesized HA, Ag-HA, and Fe-HA nanopowders were 17.23 A^o, 9.155 A^o, and 9.4363 A^o, respectively. The mean crystallite sizes of the nanopowders increased with increase in the calcination.

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引用次数: 0

Probing the role of zinc ion in metallo-β-lactamase inhibitor binding by using multiple molecular dynamics simulations

IF 2.5 Q2 CHEMISTRY, MULTIDISCIPLINARY

Results in Chemistry

Pub Date : 2025-03-05 DOI: 10.1016/j.rechem.2025.102171

Guodong Zheng , Wuxia Liu , Yining Kang , Bing Xu , Xiaoou Qiu , Tingting Du , Shenqian Xu , Ruohua Chen , Hui Cheng , Chen Cai

The hydrolysis of the β-lactam ring of antibiotics mediated by Verona Integrin-encoded metallo-β-lactamase 2 (VIM-2) in the presence of two zinc ions (Zn1 and Zn2) leads to significant resistance toward β-lactam antibiotics. Here, multiple molecular dynamics (MD) simulations were performed on two systems, including VIM-2 with two Zn1 and Zn2 ions and a single Zn1 ion, to unravel the molecular mechanism of conformational changes of VIM-2 induced by the removal of Zn2 ion and the role of Zn2 in the binding of the VIM-2 inhibitor (ANT431). The results suggest that the binding of two zinc ions stabilizes the two flexible L3 and L10 loops constituting the binding site for ANT431, whereas in the presence of a single Zn1 ion, the L3 and L10 loops exhibit an enhanced conformational flexibility. Further structural analyses reveal that the binding of two zinc ions maintains a closed conformation of ANT431 binding site, while the ANT431 binding site mainly exists as an open conformation without the Zn2 ion. Consistently, ANT431 remains stable in the active site of VIM-2 in the presence of two zinc ions, while it escapes from the active site in the presence of a single Zn1 ion. We anticipate that our results may offer useful dynamical information pertaining to conformational changes of VIM-2 for the design of potent and selective inhibitors to alleviate drug resistance of VIM-2 toward antibiotics.

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引用次数: 0

Scaffolds of biologically active heterocyclic compounds for discovery of potential drug against SARS-CoV-2 用于发现抗 SARS-CoV-2 潜在药物的生物活性杂环化合物支架

IF 2.5 Q2 CHEMISTRY, MULTIDISCIPLINARY

Results in Chemistry

Pub Date : 2025-03-05 DOI: 10.1016/j.rechem.2025.102154

Archana R. Patil , Basappa C. Yallur , Geetika Pant , Eliza Ahmed , S.G. Prasanna Kumar , Sheetal R. Batakurki , Anjanapura V. Raghu

The unabated increase of severe acute respiratory syndrome coronavirus has wreaked havoc at a very large scale. In various direct and indirect ways, the non-living realm is also impacted. Severe health emergencies have broken out globally since 2002, with the advent of SARS CoV that was followed by the MERS CoV outbreak in 2012. The pandemic caused by the novel coronavirus, SARS CoV-2, that broke out in December 2019 in China has led to an approximate 76, 77,26, 861 confirmed cases and the death toll reported by the World Health Organization stands at 69,48,764 deaths. The WHO reported on 8 July 2023 that a total of 13.4 billion doses of vaccine have been administered globally. Heterocyclic scaffolds are exhaustively utilised since many decades for use as antimalarial, antitubercular, anti-inflammatory, antidiabetic, antimicrobial, anticancer and antiviral agents. In this review, therefore, we are emphasizing the expected role of cyclic frameworks and its compounds of nine common biologically important imidazoles, benzimidazoles, indoles, oxazoles, pyrazoles, pyridines, pyrimidines, pyrroles, and thiazoles in the design and discovery of novel drugs for combating SARS CoV-2. This has been done by the exploration of available scientific articles and literature that show a variety of heterocyclic moieties that target MERS, SARS and SARS CoV-2 viruses. The heterocyclic moiety and its derivatives discussed in this investigation may be considered essential sources for creating new approaches to treating the SARS coronavirus.

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引用次数: 0

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