Results in Chemistry最新文献

{"title":"Quantification on fire-processing intensity effects on selaginellae herba carbonisata quality using integrated colorimetric and chemical analysis","authors":"Wenting Zhong ,&nbsp;Xi Wang ,&nbsp;Lixia Chen ,&nbsp;Menghua Wu ,&nbsp;Zhiguo Ma ,&nbsp;Hui Cao ,&nbsp;Ying Zhang","doi":"10.1016/j.rechem.2026.103073","DOIUrl":"10.1016/j.rechem.2026.103073","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the quantitative correlation between color parameters and chemical component variations in Selaginellae Herba (SH) processed products under different firing intensities, integrating chromatographic and microscopic imaging techniques to establish objective quality control indicators for the traditional Chinese medicine processing theory of “preserving the herbal drug's nature after carbonization by stir-heating”.</div></div><div><h3>Methods</h3><div>We employed a Multivariate analytical approach to analyze samples representing distinct processing stages: crude (Selaginellae Herba crude, SH-Cr), optimally carbonized (Selaginellae Herba Carbonisata, SH-Ca), insufficiently carbonized SH-Ca (ISH-Ca) and excessively‑carbonized SH-Ca (ESH<img>Ca). These samples underwent macroscopic and microscopic colorimetric analysis using CIE <em>L</em>*<em>a</em>*<em>b</em>* measurements. Their contents of three bioactive biflavonoids—amentoflavone, sotetsuflavone, and isocryptomerin—were quantified via high-performance liquid chromatography (HPLC). Data integration and analysis were performed using partial least squares-discriminant analysis (PLS-DA) alongside correlation studies to identify key discriminative markers.</div></div><div><h3>Results</h3><div>The integrated analytical results demonstrated systematic changes across multiple scales during carbonization. Macroscopic and microscopic colorimetric analysis showed progressive darkening, with <em>L</em>* values decreasing significantly from SH-Cr to ESH<img>Ca, accompanied by tissue-specific colorimetric responses. HPLC quantification revealed distinct degradation profiles of the bioactive biflavonoids, indicating that amentoflavone exhibited greater thermal stability than sotetsuflavone, the latter of which degraded completely in ESH<img>Ca. Multivariate statistical modeling effectively discriminated processing stages (R²Y = 0.664, Q² = 0.656), and identified microscopic color parameters, particularly epidermal cell a* values (VIP &gt; 1.5), as more effective quality markers than macroscopic features.</div></div><div><h3>Conclusion</h3><div>This study establishes that microscopic color parameters, particularly the <em>a</em>* value of epidermal cells, serve as sensitive indicators of the chemical transformations occurring during SH carbonization. These findings provide a scientific basis for utilizing microscopic colorimetry in the quality control of carbonized traditional medicines.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"21 ","pages":"Article 103073"},"PeriodicalIF":4.2,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146075204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical screening, antimicrobial activity, TLC profiling, FTIR-ATR spectroscopic analysis and GC–MS profiling of Lepisanthes rubiginosa leaf extract","authors":"Md. Mahadi Hasan ,&nbsp;Md. Shawon Miah ,&nbsp;Naim Mahmud ,&nbsp;Most. Humayra Binta Rashid ,&nbsp;Bijoy Chandra Ghos ,&nbsp;Jaytirmoy Barmon","doi":"10.1016/j.rechem.2026.103085","DOIUrl":"10.1016/j.rechem.2026.103085","url":null,"abstract":"<div><div>The discovery and ethnomedicinal applications of <em>Lepisanthes rubiginosa</em> were elucidated through comprehensive ethnobotanical observations among indigenous populations residing in forest and semi-forest ecosystems. It was utilized for its key role as medicament for long time with medicinal and economic value. Therefore, the primary objective of the current study was to perform a comprehensive phytochemical analysis, antimicrobial activity, chromatographic analysis and chemical profiling of <em>L. rubiginosa</em> leaf extract. The antibacterial activity was assessed using the disc diffusion method and in chromatographic analysis TLC was utilized to separate the methanolic extract using a solvent system consisting of n-Hexane, Ethyl Acetate (EtOAc), methanol (MeOH) and chloroform (CHCl₃). Moreover, methanolic extract was characterized using FTIR-ATR and GC–MS. Phytochemical screening showed the presence of sugar, glycosides, alkaloids, tannins, phenolic content (106.57 ± 11.25 mg GAE/g) and flavonoid content (88.72 ± 3.34 QE mg/g). In antimicrobial assessments, the dose of 500 μg/disc showed the highest inhibition against the gram-negative bacterium <em>Shigella boydii</em> and the inhibitory zone measured 26.2 ± 1.2 mm whereas in <em>Bacillus subtilis</em>, a gram-positive bacterium, the dosage of 250 μg/disc showed the least amount of inhibition and that was 9.0 ± 0.4 mm. TLC results showed ethyl acetate: n-hexane (4,1) ratio separates five compounds from the extract and their R_f values were 0.14, 0.22, 0.33, 0.48, and 0.82 respectively. FTIR analysis confirms the presence of functional groups like aldehydes, ketones, ethers, esters, amines, alcohols <em>etc.</em> Twelve compounds were identified using GC–MS, with the highest percentage (64.10%) being phenol, 2,4-bis(1,1-dimethylethyl). Further investigation will be needed for isolation and characterization of bioactive compounds.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"21 ","pages":"Article 103085"},"PeriodicalIF":4.2,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146036250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of carbon and boron nitride nanotubes for efficient encapsulation and delivery of niraparib","authors":"Arefeh Esmaeili","doi":"10.1016/j.rechem.2026.103082","DOIUrl":"10.1016/j.rechem.2026.103082","url":null,"abstract":"<div><div>Niraparib, a potent Poly (ADP-ribose) Polymerase (PARP) inhibitor, has shown considerable efficacy against ovarian cancer and other high-grade malignancies. However, its poor aqueous solubility and limited bioavailability remain significant challenges for clinical application. This study utilizes Molecular Dynamics (MD) and Steered Molecular Dynamics (SMD) simulations to systematically assess the encapsulation efficiency and membrane translocation behavior of Niraparib (NPR) within Boron Nitride Nanotubes (BNNTs) and Carbon Nanotubes (CNTs). Additionally, quantum mechanical calculations were conducted to evaluate the electronic properties and reactivity of NPR, providing insights into its non-covalent interactions with the nanotubes. MD simulation results reveal that BNNTs exhibit superior encapsulation efficiency over CNTs, demonstrated by stronger van der Waals interactions, higher atomic contact numbers, and enhanced hydrogen bonding with NPR. Analysis of Radius of Gyration (Rg), Radial Distribution Function (RDF), and Solvent Accessible Surface Area (SASA) confirms that BNNT provides a more stable and structured encapsulation environment. Furthermore, SMD simulations indicate that the BNNT@NPR complex exhibits a lower energy barrier and smoother force-displacement profile during translocation across a Dipalmitoylphosphatidylcholine (DPPC) lipid bilayer, suggesting enhanced membrane permeability compared to CNT@NPR. This superior performance is attributed to stronger interactions between BNNT and NPR, resulting in enhanced structural integrity and effective encapsulation. Overall, BNNTs demonstrate excellent potential as nanocarriers for Niraparib, offering improved drug stability, efficient cellular uptake, and enhanced biocompatibility. These findings establish BNNTs as a promising platform for nanoparticle-based drug delivery, warranting further experimental validation and in vivo studies to confirm their clinical applicability.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"21 ","pages":"Article 103082"},"PeriodicalIF":4.2,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146036357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new hydrazone ligand and its cu(II) and cd(II) complexes: Interaction with DNA and HSA, molecular docking and DFT calculations","authors":"Elham Moradinia ,&nbsp;Mohammadreza Mansournia ,&nbsp;Zahra Aramesh-Boroujeni ,&nbsp;Abdol-Khalegh Bordbar","doi":"10.1016/j.rechem.2025.103012","DOIUrl":"10.1016/j.rechem.2025.103012","url":null,"abstract":"<div><div>The present work includes the condensation of isophthalaldehyde with p-toluic hydrazide in ethanolic solution to prepare the Schiff base ligand. In the following, the resulting tetradentate ligand (H₂L) was complexed with copper(II) and cadmium(II) to form Cu₂L₂ and [Cd₂(H₂L)₂Cl₂]Cl₂, respectively. In order to identify synthesized samples, FT-IR spectra, ¹H NMR spectra, elemental analyses and UV–Vis methods were used. The interaction of fish salmon-DNA (FS-DNA) and human serum albumin (HSA) with all synthesized compounds were explored with the help of UV–vis absorption, fluorescence and molecular docking methods. According to the investigations, it was confirmed that the ligand and its complexes bind to DNA and HSA through Van der Waals interactions and hydrogen bonds. Moreover, density functional theory (DFT) studies of synthesis complexes were performed to determine the structural and electronic properties.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"21 ","pages":"Article 103012"},"PeriodicalIF":4.2,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146075148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and biological evaluation of heteroarylnitrile derivatives for motile ciliogenesis","authors":"Gwi Bin Lee ,&nbsp;Gopalakrishnan Chandrasekaran ,&nbsp;Da Bin Jeon ,&nbsp;Chan-Young Park ,&nbsp;Parvathi Varier Sundareswaran ,&nbsp;Byeong Wook Choi ,&nbsp;Pyeongkeun Kim ,&nbsp;Jihyeon Yoon ,&nbsp;Seok-Yong Choi ,&nbsp;Jin Hee Ahn","doi":"10.1016/j.rechem.2026.103078","DOIUrl":"10.1016/j.rechem.2026.103078","url":null,"abstract":"<div><div>Motile cilia play a critical role in maintaining tissue homeostasis by driving fluid movement and clearing inhaled particles or pathogens. Dysfunction of these organelles underlies a range of ciliopathies, most notably affecting the respiratory system. Building on previous studies that identified molecules promoting motile cilia formation, we tried to discover novel small molecules that enhance motile ciliogenesis. To this end, we conducted a phenotype-based high-throughput screen using a Tg(foxj1a:eGFP) zebrafish reporter line, which led to the identification of a new chemotype hit. Subsequent structure–activity relationship (SAR) studies resulted in the development of compound <strong>19b</strong>, which promoted motile cilia formation in zebrafish embryos. Its efficacy was further validated in ex vivo air–liquid interface (ALI) cultures of mouse tracheal epithelial cells, where treatment with <strong>19b</strong> significantly increased the number of multiciliated cells. These findings suggest that compound <strong>19b</strong> is a useful chemical probe for studying ciliogenesis and a potential lead for therapeutic development in motile ciliopathies.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"21 ","pages":"Article 103078"},"PeriodicalIF":4.2,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146075202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estrogenic activity evaluation of canned beans by combined bioassay and analytical methods","authors":"Nader Akbari ,&nbsp;Shahrbano Rostami ,&nbsp;Mahmoud Ghazi-Khansari ,&nbsp;Gholamreza Jahed- Khaniki ,&nbsp;Nabi Shariatifar ,&nbsp;Parisa Sadighara","doi":"10.1016/j.rechem.2026.103081","DOIUrl":"10.1016/j.rechem.2026.103081","url":null,"abstract":"<div><div>In this study, xenoestrogens or estrogenic compounds were evaluated in canned beans. For this purpose, the estrogenic activity of canned beans was evaluated using bioassay and advanced analytical tests. After ensuring the safety and quality of canned beans, the samples were extracted with solvents. High performance liquid chromatography, quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF-MS) were performed to identify compounds and bioassay tests with the prepared extracts. The extracts were placed in the vicinity of human MCF-7 cells. These cells have estrogen receptors. An <em>E</em>-screen test was done, and cells increased compared to the positive control group (17β-estradiol). A reverse transcription-quantitative polymerase chain reaction (RT-qPCR) test was also performed to evaluate the level of binding to estrogen receptors, and finally, the compounds in the extract were identified with HPLC-Q-TOF-MS. The MCF-7 proliferation rate ranged from 47 to 71%, confirming moderate estrogenic activity. RT-qPCR revealed higher ERβ expression (3.2-fold) than ERα (2.6-fold). HPLC-QTOF-MS identified phytoestrogens (genistein, daidzein, equol, coumestrol, biochanin A) and bisphenol A as major contributors. The combined bioassay-analytical methods provides a reliable results for detecting endocrine active substances in food products.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"21 ","pages":"Article 103081"},"PeriodicalIF":4.2,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146075205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated experimental and computational investigation of a novel carbazole-based dihydropyridine derivative: Synthesis, spectroscopic analysis, molecular docking, and dynamics studies","authors":"R. Karthick ,&nbsp;G. Velraj ,&nbsp;Ramesh Kumar Raji ,&nbsp;A. Karuppusamy ,&nbsp;S. Karthikeyan ,&nbsp;Naser Qamhieh ,&nbsp;Fathalla Hamed","doi":"10.1016/j.rechem.2026.103080","DOIUrl":"10.1016/j.rechem.2026.103080","url":null,"abstract":"<div><div>Diethyl 4-(4-(9H-carbazol-9-yl)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate (DHPC) is a novel compound with potential pharmacological and biomedical applications. Its unique structural features and electronic properties make it a promising candidate for drug discovery and molecular interaction studies. This novel compound, DHPC was synthesized using the classical Hantzsch route. Comprehensive experimental and theoretical studies were conducted to investigate its structural, vibrational, NMR, and electronic properties. Density Functional Theory (DFT) calculations employing the B3LYP exchange-correlation functional were used to correlate molecular and structural characteristics. The electronic properties of DHPC, including the energy band gap between the HOMO-LUMO orbitals, were calculated using TD-DFT/B3LYP/6–311++G(d,p) basis set. Natural Bond Orbital (NBO) analysis was performed to evaluate the compound's strength and stability. The ¹H NMR and ¹³C NMR spectra were investigated using the Gauge-Independent Atomic Orbital (GIAO) method, with tetramethylsilane (TMS) as a reference. Global reactivity parameters such as Fukui functions, and the molecular electrostatic potential (MEP) map were employed to identify reactive sites within the compound. These DFT-derived electronic and structural insights contribute to understanding the potential pharmacological actions of DHPC. Further, molecular docking analysis was performed to identify the binding interactions of the ligand with target proteins, revealing the possible binding sites. The stability and dynamics of the protein-ligand complex were assessed through molecular dynamics simulations. These integrated studies provide a robust framework for exploring DHPC's potential in pharmacological and biomedical applications.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"21 ","pages":"Article 103080"},"PeriodicalIF":4.2,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146036359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance evaluation of a de-embedded de-alloyed Cu2+1O/cu/Si@C anode material used in lithium-ion batteries","authors":"Zhanshou Yang ,&nbsp;Fafeng Xu ,&nbsp;Yuhong Li ,&nbsp;Zhengrong Niu ,&nbsp;Bo Li ,&nbsp;Haitao Feng ,&nbsp;Jinbo Zeng ,&nbsp;Keli Yang ,&nbsp;Honghui Liu","doi":"10.1016/j.rechem.2026.103079","DOIUrl":"10.1016/j.rechem.2026.103079","url":null,"abstract":"<div><div>Lithium-ion batteries (LIBs) are widely used in new energy vehicles, portable electronic products and power batteries owing to their high open-circuit voltage, high specific energy and low self-discharge rate. The embedded graphite anodes of LIBs have a low theoretical specific capacity and cannot meet the requirements of high-energy-density electronic devices. Herein, an Al–Mg–Cu–Si–Sn alloy was first prepared via melting, and a Cu₂₊₁O/Cu/Si composite was subsequently synthesized via de-alloying. Furthermore, the composite was coated with carbon to obtain Cu₂₊₁O/Cu/Si@C—an LIB anode material exhibiting a high energy density. The physical phase, microstructure and lithium-storage performance of the de-embedded Cu₂₊₁O/Cu/Si@C anode material were analyzed via characterization methods such as X-ray diffraction, scanning electron microscopy–energy-dispersive X-ray spectroscopy (EDS), transmission electron microscopy–EDS and electrochemical analysis. The anode material exhibited a specific capacity of 995.6 mAh/g, a first-time Coulombic efficiency of 75.5%, a specific capacity of 604.4 mAh/g after 500 charge/discharge cycles and good multiplicative rate performance at current densities of &lt;1C.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"21 ","pages":"Article 103079"},"PeriodicalIF":4.2,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146036352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aird 2.0: High-performance mass spectrometry data format optimized for computational analysis","authors":"Xixi Wang ,&nbsp;Miaoshan Lu ,&nbsp;Junjie Tong ,&nbsp;Shuochao Li ,&nbsp;Changbin Yu","doi":"10.1016/j.rechem.2026.103083","DOIUrl":"10.1016/j.rechem.2026.103083","url":null,"abstract":"<div><div>Background: The escalating volume of data generated by mass spectrometry (MS) presents a significant bottleneck for large-scale computational analysis. While data compression is crucial, the primary challenge lies in accelerating data access for processing-intensive tasks. To address this, we introduce Aird 2.0, a high-performance data format engineered for rapid data retrieval and efficient storage. Results: Aird 2.0 features a novel, dynamic compression framework that intelligently selects from six specialized algorithms to optimize performance for any given MS file. Our comprehensive evaluation on 58 public datasets demonstrates that Aird 2.0 achieves a 2.8-fold increase in random-access speed and a 6-fold increase in full-file loading speed compared to the standard mzML format, while also reducing file sizes by an average of 12.3% over its predecessor, Aird 1.0. Additionally, it enhances metadata deserialization speed by 2.5-fold and halves metadata file size, further accelerating analysis workflows.</div><div>Significance: Supported by a comprehensive conversion client (AirdPro) and SDKs for Java and C#. Aird 2.0 is a comprehensive, open-source solution for accelerating the analysis of large-scale Mass Spectrometry data. It provides a high-performance data format that can be seamlessly integrated into existing software ecosystems, offering a robust foundation for future research and development.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"21 ","pages":"Article 103083"},"PeriodicalIF":4.2,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146075152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-mode chemosensing of iron ions by new schiff bases derived from cinnamyl 5,5′-dimethyl- and diphenylhydantoins","authors":"Stela Georgieva ,&nbsp;Petia Peneva ,&nbsp;Le Thi Mai Hoa ,&nbsp;Petar Todorov","doi":"10.1016/j.rechem.2026.103065","DOIUrl":"10.1016/j.rechem.2026.103065","url":null,"abstract":"<div><div>Two novel hydantoin–cinnamic Schiff bases were synthesized and fully characterized using several analytical techniques, with the aim of evaluating their potential as smart chemosensors for heavy metal ions. Given the electron-donating characteristics of the hydantoin and cinnamic fragments, both compounds (1E,2E)-5,5′-dimethyl-3-((3-phenylallylidene)amino)imidazolidine-2,4-dione (K1) and (1E,2E)-5,5′-diphenyl-3-((−3-phenylallylidene)amino)imidazolidine-2,4-dione (K2) were examined by electrochemical and spectral (UV–Vis and fluorimetry) methods to determine their fundamental chemical behavior. Parallel studies used UV–Vis and fluorimetry to analyze the metal ions by complexation in solution. The greatest signal change was observed in the presence of Fe³⁺, with the candidate for its sensor detection with the highest sensitivity being the hydantoin cinnamyl Schiff base (K1). A mercury droplet working electrode was used to detect Fe³⁺ after complexation with K1 and K2. Evidence for the formation of new complex compounds was provided by scanning in cyclic and DPP modes, and experiments were applied for Fe³⁺ recognition using the organic ligands. The effectiveness of the new spectral and electrochemical methods was assessed based on how accurate, precise, and sensitive they were for detecting Fe³⁺. The establishment of two separate but useful methods—spectrofluorometric and electrochemical—for the detection of Fe³⁺ using one type of organic ligand provides a clear advantage for the analysis. The dual-mode sensing capability of the new investigated Schiff base would allow flexible adaptation to different analytical platforms and sample types. This flexibility increases reliability through cross-validation and reduces the dependence on a single detection technique.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"21 ","pages":"Article 103065"},"PeriodicalIF":4.2,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146036251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}