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Drift-free memory material for wide-temperature neuromorphic computing 用于宽温神经形态计算的无漂移记忆材料。
IF 21.1 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-02-28 Epub Date: 2025-12-16 DOI: 10.1016/j.scib.2025.12.024
Siqi Tang , Pandeng Xuan , Yisi Xiong , Ming Xu , Riccardo Mazzarello , Xiangshui Miao
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引用次数: 0
Insufficient oxidation capacity in the photooxidation of aromatic VOCs results in underestimation of SOA yield 芳香族挥发性有机化合物光氧化能力不足导致SOA产率被低估。
IF 21.1 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-02-28 Epub Date: 2026-01-12 DOI: 10.1016/j.scib.2026.01.016
Tianzeng Chen , Jun Liu , Biwu Chu , Yanli Ge , Peng Zhang , Qingxin Ma , Hong He
Secondary organic aerosols (SOA), a major constituent of fine particulate matter (PM2.5), influence atmospheric chemistry, climate, and public health. However, their formation processes remain insufficiently represented in atmospheric models due to their complexity. Here, we investigate SOA formation from representative aromatic hydrocarbons (toluene, m-xylene, and 1,3,5-trimethylbenzene) under varying precursor concentrations using controlled smog chamber experiments. Leveraging high-resolution mass spectrometry and machine learning approaches, we demonstrate that oxidation capacity (characterized by the cumulative OH exposure), modulated by precursor concentration, is the primary driver of SOA yield. A key and novel finding is that at lower precursor concentrations (∼10 ppb), which are more representative of real atmospheric conditions, the enhanced OH exposure per molecule promotes more efficient multigenerational oxidation. This process favors the production of low-volatility organic compounds, thereby substantially increasing SOA formation compared to that at higher precursor concentrations. These findings, validated by the machine learning analysis, provide mechanistic insights into SOA evolution and underscore the need for improved representation of multigenerational oxidation in atmospheric models to enhance air quality and climate predictions.
二次有机气溶胶(SOA)是细颗粒物(PM2.5)的主要组成部分,影响大气化学、气候和公众健康。然而,由于它们的复杂性,它们的形成过程在大气模式中仍然没有得到充分的体现。在这里,我们使用可控烟雾室实验研究了在不同前体浓度下代表性芳香烃(甲苯、间二甲苯和1,3,5-三甲苯)形成SOA的过程。利用高分辨率质谱法和机器学习方法,我们证明了氧化能力(以累积OH暴露为特征),由前体浓度调制,是SOA产率的主要驱动因素。一个关键的新发现是,在更能代表真实大气条件的较低前体浓度(~ 10 ppb)下,每个分子OH暴露的增强促进了更有效的多代氧化。该工艺有利于低挥发性有机化合物的生产,因此与较高前体浓度相比,大大增加了SOA的形成。这些发现经过机器学习分析的验证,为SOA演变提供了机制见解,并强调了在大气模型中改进多代氧化表征以增强空气质量和气候预测的必要性。
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引用次数: 0
The saline flavor of deep continental energy 深层大陆能量的咸味。
IF 21.1 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-02-28 Epub Date: 2025-12-19 DOI: 10.1016/j.scib.2025.12.030
Alberto Vitale Brovarone
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引用次数: 0
Global, regional, and national burden of hepatocellular carcinoma and contribution of nine modifiable risk factors across 185 countries/territories in 2022 2022年185个国家/地区的全球、区域和国家肝细胞癌负担和9个可改变危险因素的贡献
IF 21.1 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-02-28 Epub Date: 2025-12-18 DOI: 10.1016/j.scib.2025.12.022
Ping Li , Zhan Ding , Yuqi Feng , Xiangyu Ren , Yongyue Wei , Changfa Xia , Yitao Yang , Quanbo Yang , Zhe Wang , Xuehong Zhang , L.G. van der Geest , Herbert Yu , Edward Giovannucci , David P. Smith , Michael David , Ahmedin Jemal , Xue Qin Yu , Hongmei Zeng , Guangwen Cao
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. However, no previous studies systematically provided global HCC burden and population attributable fractions (PAFs) of major risk factors for HCC at the global, regional, subregional, and national levels. We conducted a population-based study to assess the global burden of HCC and the contribution of nine modifiable risk factors. We used data from GLOBOCAN 2022, CI5, GBD 2021, and other large-scale data sources. We categorized nine major modifiable risk factors as infections (hepatitis B or C virus [HBV, HCV], or C. sinensis), metabolic factors (obesity, type 2 diabetes mellitus, and metabolic dysfunction-associated steatotic liver disease [MASLD]), and behavioral/toxic factors (high alcohol use, smoking, and aflatoxin B1). In 2022, globally, there were 684,659 new HCC cases and 597,434 deaths, with the highest age-standardized rates observed in Eastern Asia and Northern Africa. An estimated 78.4% (536,571/684,659) of global HCC cases were attributable to the evaluated risk factors, with 82.5% in Asia and 60.4% in America. Infections contributed most worldwide (65.9%), followed by behavioral/toxic risk factors (22.4%) and metabolic factors (19.7%). Region-specific predominant risk factors included HBV in Eastern Asia (72.5%), HCV in Northern Africa (43.9%), smoking in Northern America (24.5%), and high alcohol use in Western Europe (24.9%). Between 1990 and 2022, infection and behavioral/toxic factors declined globally, whereas metabolic factors steadily increased. The substantial variations in HCC burden and PAF across regions highlight the importance of tailored, region-specific preventive interventions to address the varying modifiable risk factors.
肝细胞癌(HCC)是最常见的原发性肝癌类型。然而,之前没有研究系统地在全球、区域、次区域和国家层面提供HCC主要危险因素的全球HCC负担和人口归因分数(paf)。我们进行了一项基于人群的研究,以评估HCC的全球负担和9个可改变的危险因素的贡献。我们使用的数据来自GLOBOCAN 2022、CI5、GBD 2021和其他大型数据源。我们将9个主要的可改变的危险因素分类为感染(乙型肝炎或丙型肝炎病毒[HBV, HCV]或C. sinensis),代谢因素(肥胖,2型糖尿病和代谢功能障碍相关的脂肪变性肝病[MASLD])和行为/毒性因素(大量饮酒,吸烟和黄曲霉毒素B1)。2022年,全球有684,659例HCC新发病例和597,434例死亡,东亚和北非的年龄标准化率最高。估计78.4%(536,571/684,659)的全球HCC病例可归因于评估的危险因素,其中82.5%在亚洲,60.4%在美国。在世界范围内,感染因素占多数(65.9%),其次是行为/毒性危险因素(22.4%)和代谢因素(19.7%)。区域特异性的主要危险因素包括东亚的HBV(72.5%)、北非的HCV(43.9%)、北美的吸烟(24.5%)和西欧的高酒精使用(24.9%)。1990年至2022年间,全球感染和行为/毒性因素下降,而代谢因素稳步上升。不同地区HCC负担和PAF的巨大差异突出了针对不同地区的预防干预措施的重要性,以解决不同的可改变的风险因素。
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引用次数: 0
Controllable deterministic quantum teleportation of multiple sideband qumodes 多边带模的可控确定性量子隐形传态。
IF 21.1 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-02-28 Epub Date: 2025-12-30 DOI: 10.1016/j.scib.2025.12.047
Na Wang , Meihong Wang , Chun Ma , Xuefan Xing , Dongmei Han , Xiaolong Su
As an important quantum communication protocol, quantum teleportation has broad applications in quantum information science and technology. For the application, it is essential to enhance the ability of quantum teleportation by teleporting multiple quantum states simultaneously. Here, we experimentally demonstrate deterministic quantum teleportation of multiple sideband qumodes of coherent states, which corresponds to teleporting multiple quantum states simultaneously, with the assistance of continuous-variable (CV) quantum entanglement. By fine-tuning the phases of two classical channels according to different adjustable frequencies, we successfully realize deterministic CV quantum teleportation with up to 5 sideband qumodes simultaneously within the frequency bandwidth of 24 MHz. We show that the number of teleported multiple qumodes is controllable by changing the phases of two classical channels. The obtained fidelities of output multiple qumodes are around 70%, which are all beyond the non-cloning limit. The results present a novel method for quantum teleportation of multiple quantum states simultaneously and take a crucial step in enhancing the teleporting ability of quantum teleportation.
量子隐形传态作为一种重要的量子通信协议,在量子信息科学与技术中有着广泛的应用。在实际应用中,通过同时传送多个量子态来增强量子隐形传态的能力至关重要。本文利用连续变量(CV)量子纠缠,实验证明了相干态的多个边带模的确定性量子隐形传态,对应于同时传送多个量子态。通过对两个经典信道的相位根据不同的可调频率进行微调,我们成功地在24 MHz的频率带宽内实现了多达5个边带量子模的确定性CV量子隐形传态。我们证明了通过改变两个经典信道的相位可以控制传送多模的数量。得到的输出多模保真度在70%左右,均超过了非克隆极限。研究结果提出了一种同时实现多个量子态的量子隐形传态的新方法,为提高量子隐形传态的传输能力迈出了关键的一步。
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引用次数: 0
A pleiotropic regulator AtrA undergoes liquid-liquid phase separation in regulating quorum sensing 多效调节剂AtrA在调节群体感应时经历液-液相分离。
IF 21.1 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-02-28 Epub Date: 2025-09-10 DOI: 10.1016/j.scib.2025.09.013
Bingbing Ma , Xiaoyue Hu , Chenfan Sun , Jijin Xie , Yangyang Luo , Beibei Wang , Youjun Feng , Hangjin Jiang , Qingwei Zhao , Xuming Mao
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引用次数: 0
Single-cell omics analysis reveals tumor microenvironment rewiring after arsenic trioxide therapy in acute promyelocytic leukemia 单细胞组学分析揭示急性早幼粒细胞白血病三氧化二砷治疗后肿瘤微环境重新布线。
IF 21.1 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-02-28 Epub Date: 2025-09-10 DOI: 10.1016/j.scib.2025.09.014
Gang Xu , Jiyu Guo , Shengjin Fan , Si Li , Ting Qiu , Zefeng Chen , Yanan Liu , Luan Wen , Chongwen Lv , Yanan Jiang , Huitao Fan , Juan Xu , Wei Wang , Yongsheng Li
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引用次数: 0
Organic chemicals of Arctic concern in Russian coastal seas 俄罗斯沿海海域的北极问题有机化学品。
IF 21.1 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-02-28 Epub Date: 2025-12-31 DOI: 10.1016/j.scib.2025.12.054
Xi-Ze Min , Xianming Zhang , Zhi-Yong Xie , Anatoly Nikolaev , Katrin Vorkamp , Jian-Min Ma , Lars-Otto Reiersen , Li Li , Ming-Hong Cai , Nan-Qi Ren , Yi-Fan Li , Zi-Feng Zhang , Roland Kallenborn , Derek Muir
Arctic ecosystems face significant threats from chemicals of global concern. Persistent organic pollutants (POPs) and polycyclic aromatic hydrocarbons (PAHs) have been consistently detected in the Arctic through decades of monitoring. POPs are known to bioaccumulate in food webs, and both POPs and PAHs are toxic posing risks to wildlife and human health. While regular monitoring activities have been implemented in most Arctic countries, information from the Russian Arctic is still limited. This review synthesizes the existing knowledge on environmental fate and distribution pathways of POPs, PAHs, and Chemicals Of Emerging Arctic Concern (CEACs) in the Russian Arctic. Except for recent studies on microplastics, data on CEACs remain very limited. Considering mass exchange processes between environmental compartments, including the cryosphere, this review focuses on the Russian Arctic coastal seas, where riverine transport and atmospheric deposition are the main sources of legacy POPs and PAHs. Northward-draining Russian Arctic rivers have been loading legacy POPs from historical sources to coastal seawater. Ongoing volatilization of low-molecular-weight PAHs from both sediments and seawater in the Russian Arctic coastal seas is likely to be accelerated with the ongoing warming climate. PAH and POPs stored in the cryosphere of the Russian Arctic are expected to be released with the ice/snow melting and permafrost thaws. However, more up-to-date information on these chemicals is needed to evaluate these processes and their significance for Arctic pollution.
北极生态系统面临着全球关注的化学品的重大威胁。通过几十年的监测,北极地区一直检测到持久性有机污染物(POPs)和多环芳烃(PAHs)。众所周知,持久性有机污染物会在食物网中生物积累,持久性有机污染物和多环芳烃都是有毒的,对野生动物和人类健康构成风险。虽然在大多数北极国家开展了定期监测活动,但来自俄罗斯北极的信息仍然有限。本文综述了俄罗斯北极地区持久性有机污染物、多环芳烃和新兴北极关注化学品(CEACs)的环境命运和分布途径的现有知识。除了最近对微塑料的研究外,关于ceac的数据仍然非常有限。考虑到包括冰冻圈在内的环境区域之间的物质交换过程,本综述将重点放在俄罗斯北极沿海海域,在那里,河流运输和大气沉积是遗留的持久性有机污染物和多环芳烃的主要来源。向北排水的俄罗斯北极河流将历史上遗留下来的持久性有机污染物装载到沿海海水中。俄罗斯北极沿海沉积物和海水中低分子量多环芳烃的持续挥发可能会随着持续变暖的气候而加速。储存在俄罗斯北极冰冻圈的多环芳烃和持久性有机污染物预计将随着冰雪融化和永久冻土融化而释放。然而,需要更多关于这些化学物质的最新信息来评价这些过程及其对北极污染的意义。
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引用次数: 0
Mapping biology in space: from spatial transcriptomics platforms to analytical tools and databases 空间生物学制图:从空间转录组学平台到分析工具和数据库。
IF 21.1 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-02-28 Epub Date: 2026-01-20 DOI: 10.1016/j.scib.2026.01.034
Zi-Zhen Guo , Renyan Wu , Weixiang Li , Keyu Yang , Xuexiang Ying , Hamid Alinejad-Rokny , Youqiong Ye
Spatial transcriptomics (ST) has become a key technology for interrogating gene expression within spatial context, providing spatially resolved insights into tissue architecture and microenvironmental organization. Rapid advances in experimental platforms and analytical methods, however, have resulted in challenges for technology selection, methodological comparison, and data interpretation. In this review, we present a systematic summary of 594 ST analysis tools spanning 77 ST technologies (as of September 2025). We outline the complete analytical workflow and discuss major analytical tasks, including data preprocessing, denoising and imputation, spatial pattern and domain identification, cellular composition, trajectory analysis, cell-cell communication, and spatial multi-omics integration. For each task, we summarize representative methodological principles and emphasize platform-dependent considerations arising from differences in spatial resolution and detection efficiency. We further highlight how analytical applications of ST data have enabled biomedical discoveries by revealing spatial heterogeneity, tissue organization, and context-dependent cellular interactions. Furthermore, we develop SpatialToolDB (https://www.spatialtooldb.yelab.site/), a systematically curated, categorized, and continuously updated platform that integrates the ST technologies, analytical methods, and related databases covered in this review, facilitating informed tool selection and method comparison. We also discuss development trends and future directions of spatial-omics technologies and analytical tools, including advances in spatial technologies, AI-driven computation, benchmarking and standardization, and improved experimental validation for mechanistic and predictive spatial biology. Together, this review and SpatialToolDB provide a data-driven foundation for selecting ST platforms and analytical strategies tailored to diverse biological and translational research applications.
空间转录组学(ST)已经成为在空间背景下询问基因表达的关键技术,为组织结构和微环境组织提供空间解决的见解。然而,实验平台和分析方法的快速发展给技术选择、方法比较和数据解释带来了挑战。在这篇综述中,我们系统地总结了594种ST分析工具,涵盖77种ST技术(截至2025年9月)。我们概述了完整的分析工作流程,并讨论了主要的分析任务,包括数据预处理、去噪和imputation、空间模式和域识别、细胞组成、轨迹分析、细胞-细胞通信和空间多组学集成。对于每个任务,我们总结了具有代表性的方法原则,并强调了由于空间分辨率和检测效率差异而引起的平台依赖性考虑。我们进一步强调了ST数据的分析应用如何通过揭示空间异质性、组织组织和环境依赖的细胞相互作用来促进生物医学发现。此外,我们开发了SpatialToolDB (https://www.spatialtooldb.yelab.site/),这是一个系统策划,分类和不断更新的平台,集成了本文所述的ST技术,分析方法和相关数据库,便于明智的工具选择和方法比较。我们还讨论了空间组学技术和分析工具的发展趋势和未来方向,包括空间技术的进步,人工智能驱动的计算,基准和标准化,以及改进的机械和预测空间生物学的实验验证。综上所述,该综述和SpatialToolDB为选择适合不同生物和转化研究应用的ST平台和分析策略提供了数据驱动的基础。
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引用次数: 0
Migrion: a Migrasome-mediated unit for intercellular viral transmission 迁移体:迁移体介导的细胞间病毒传播单位。
IF 21.1 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-02-28 Epub Date: 2025-08-23 DOI: 10.1016/j.scib.2025.08.039
Yuxing Huang , Xiaojie Yan , Xing Liu , Congcong Ji , Wenmin Tian , Haohao Tang , Yong Li , Yiling Wen , Peiyao Fan , Hongli Wang , Cankun Xi , Zhongtian Li , Tian Lu , Fuping You , Xin Yin , Yang Chen
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引用次数: 0
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