The aim of this study is to determine the experiences and thoughts of pregnant women during pregnancy, delivery, and the postpartum period in the COVID-19 pandemic. The research was qualitative and conducted with 10 pregnant women, and a descriptive phenomenological method was used. The "Descriptive Information Form" and the "Semi-Structured Interview Form" were used as data collection tools. The data was analyzed using a thematic analysis technique. At the end of the interview, a total of 13 main themes and sub-themes for pregnancy, birth, and postpartum were obtained. During pregnancy, five main themes were identified under the headings of fear, restlessness and stress, anxiety, difficulty in follow-up, and precaution. For the birth, five main themes were determined under the headings of anxiety, loneliness, hope, precaution, and fear. For the postpartum period, 3 main themes emerged under the headings of anxiety, giving up on dreams, and precaution. The results of the study will be beneficial in terms of raising awareness of health professionals who care for pregnant women not only about the physical health of pregnant women but also about mental health. Holistic care should be planned and alternative care methods should be offered by considering the experiences, thoughts, and individual concerns of pregnant women. Women should be informed, guided and have access to services whenever they need them.
{"title":"PREGNANCY, BİRTH AND POSTPARTUM CARE EXPERİENCES AND THOUGHTS OF WOMEN DURING THE COVID-19 PANDEMIC: A QUALİTATİVE STUDY","authors":"Semra Elmas, Şükran Başgöl","doi":"10.55433/gsbd.254","DOIUrl":"https://doi.org/10.55433/gsbd.254","url":null,"abstract":"The aim of this study is to determine the experiences and thoughts of pregnant women during pregnancy, delivery, and the postpartum period in the COVID-19 pandemic. The research was qualitative and conducted with 10 pregnant women, and a descriptive phenomenological method was used. The \"Descriptive Information Form\" and the \"Semi-Structured Interview Form\" were used as data collection tools. The data was analyzed using a thematic analysis technique. At the end of the interview, a total of 13 main themes and sub-themes for pregnancy, birth, and postpartum were obtained. During pregnancy, five main themes were identified under the headings of fear, restlessness and stress, anxiety, difficulty in follow-up, and precaution. For the birth, five main themes were determined under the headings of anxiety, loneliness, hope, precaution, and fear. For the postpartum period, 3 main themes emerged under the headings of anxiety, giving up on dreams, and precaution. The results of the study will be beneficial in terms of raising awareness of health professionals who care for pregnant women not only about the physical health of pregnant women but also about mental health. Holistic care should be planned and alternative care methods should be offered by considering the experiences, thoughts, and individual concerns of pregnant women. Women should be informed, guided and have access to services whenever they need them.","PeriodicalId":422894,"journal":{"name":"GOBEKLİTEPE Saglik Bilimleri Dergisi","volume":"45 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120819975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The nursing process includes the development of comprehensive knowledge, skills and attitudes. Ensuring this development and gaining professional values is very important in maintaining professional life. During nursing education, the emotions experienced by student nurses while providing professional care and the meaning they give to education and profession may differ. In the presentation of the nursing profession, which has quite complex and comprehensive knowledge and theoretical background concepts, it is very important for students to be motivated, internalize nursing concepts and develop their own nursing perspectives, believe in the usefulness of their practices, manage possible sudden changes, and make the right decision and practice between ethical dilemmas. In this context, depending on individual differences, the motivation and willingness of nursing students may differ. The use of motivational interviewing approach may be beneficial for people who are needed in their preparation for the profession and in providing professional care. Motivational interviewing is defined as “a client-centered approach that provides behavior change by helping the client discover and analyze the ambivalence they experience, and makes use of directives for this”. It has many uses such as addiction treatment, healthy behavior acquisition, mental problems, diet and nutritional habits, sports gains, drug compliance. Other areas of uses that are not frequently mentioned are education and business life. Therefore, for the purpose of this review is to examine the training and practice motivations of student nurses, who are expected to gain professional care skills, from the perspective of motivational interviewing.
{"title":"THE USE OF MOTIVATIONAL INTERVIEW IN EDUCATIONS TO PROVIDE PROFESSIONAL NURSING CARE OF STUDENTS","authors":"Nilgun Kahraman, Bahanur Malak Akgün","doi":"10.55433/gsbd.244","DOIUrl":"https://doi.org/10.55433/gsbd.244","url":null,"abstract":"The nursing process includes the development of comprehensive knowledge, skills and attitudes. Ensuring this development and gaining professional values is very important in maintaining professional life. During nursing education, the emotions experienced by student nurses while providing professional care and the meaning they give to education and profession may differ. In the presentation of the nursing profession, which has quite complex and comprehensive knowledge and theoretical background concepts, it is very important for students to be motivated, internalize nursing concepts and develop their own nursing perspectives, believe in the usefulness of their practices, manage possible sudden changes, and make the right decision and practice between ethical dilemmas. In this context, depending on individual differences, the motivation and willingness of nursing students may differ. The use of motivational interviewing approach may be beneficial for people who are needed in their preparation for the profession and in providing professional care. Motivational interviewing is defined as “a client-centered approach that provides behavior change by helping the client discover and analyze the ambivalence they experience, and makes use of directives for this”. It has many uses such as addiction treatment, healthy behavior acquisition, mental problems, diet and nutritional habits, sports gains, drug compliance. Other areas of uses that are not frequently mentioned are education and business life. Therefore, for the purpose of this review is to examine the training and practice motivations of student nurses, who are expected to gain professional care skills, from the perspective of motivational interviewing.","PeriodicalId":422894,"journal":{"name":"GOBEKLİTEPE Saglik Bilimleri Dergisi","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117126811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The self is a phenomenon that begins to form from the first years of life, continues its development, can be affected by life events, and may have an impact on the mental and physical conditions of individuals. A professional nursing care is possible if a nurse is able to plan the patients' care, by discovering and figuring out their behaviors and placing their subjectivity at the center of the care. Nurse should not only assess the individuals but also consider how they see and perceive themselves and their positive and negative judgments about themselves. The aim of this review is to explain the concepts of self, self-esteem, and low and high self, which have a determining power in the future life style and relationships of individuals and they obtain by interacting with their circle and receive feedback from them. Another aim of the study is to examine importance of the factors associated with self-concept and the effects of these factors on the mental and physical conditions of individuals in planning of nursing care.
{"title":"SELF","authors":"Şeyda Öztuna, Feray Bucak","doi":"10.55433/gsbd.271","DOIUrl":"https://doi.org/10.55433/gsbd.271","url":null,"abstract":"The self is a phenomenon that begins to form from the first years of life, continues its development, can be affected by life events, and may have an impact on the mental and physical conditions of individuals. A professional nursing care is possible if a nurse is able to plan the patients' care, by discovering and figuring out their behaviors and placing their subjectivity at the center of the care. Nurse should not only assess the individuals but also consider how they see and perceive themselves and their positive and negative judgments about themselves. The aim of this review is to explain the concepts of self, self-esteem, and low and high self, which have a determining power in the future life style and relationships of individuals and they obtain by interacting with their circle and receive feedback from them. Another aim of the study is to examine importance of the factors associated with self-concept and the effects of these factors on the mental and physical conditions of individuals in planning of nursing care.","PeriodicalId":422894,"journal":{"name":"GOBEKLİTEPE Saglik Bilimleri Dergisi","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131549651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Erkan Öner, I. Demirhan, Seda Ergün, Ergul Belge Kurutas, S. Yalın
The coronavirus disease has caused the death of many people in the world and in our country. This unexpected negative health terror has left countries in a difficult situation. In this study, it was aimed to investigate Zinc Phthalocyanine-1 (ZnPc-1) against SARS-CoV-2 main protease (MPro) by in silico method. In our research, Zn-Pc-1 was enabled to target the active site of the SARS-CoV-2 MPro receptor with PDB ID:6LU7. Molecular docking study was done with Autodock program. The result of molecular docking was found to be -10.6 kcal/mol. The results obtained from the study showed that Zn-Pc-1 has a very high potential to be an inhibitor of SARS CoV-2 MPro.Key Words: Sars-Cov-2 Main Protease, Molecular Docking, Zinc Phthalocyanine
{"title":"INVESTIGATION of ZINC PHTHALOCYANİNE-1 IN SARS COV-2 MPRO by MOLECULAR DOCKING METHOD: IN SILICO STUDY","authors":"Erkan Öner, I. Demirhan, Seda Ergün, Ergul Belge Kurutas, S. Yalın","doi":"10.55433/gsbd.266","DOIUrl":"https://doi.org/10.55433/gsbd.266","url":null,"abstract":"The coronavirus disease has caused the death of many people in the world and in our country. This unexpected negative health terror has left countries in a difficult situation. In this study, it was aimed to investigate Zinc Phthalocyanine-1 (ZnPc-1) against SARS-CoV-2 main protease (MPro) by in silico method. In our research, Zn-Pc-1 was enabled to target the active site of the SARS-CoV-2 MPro receptor with PDB ID:6LU7. Molecular docking study was done with Autodock program. The result of molecular docking was found to be -10.6 kcal/mol. The results obtained from the study showed that Zn-Pc-1 has a very high potential to be an inhibitor of SARS CoV-2 MPro.Key Words: Sars-Cov-2 Main Protease, Molecular Docking, Zinc Phthalocyanine","PeriodicalId":422894,"journal":{"name":"GOBEKLİTEPE Saglik Bilimleri Dergisi","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126447132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this study, COVID-19 data announced by the Ministry of Health (2020-2021) were analyzed and Türkiye's situation in the world was evaluated by comparing it with other countries according to the World Health Organization data. The number of COVID-19 cases in Türkiye increased by 229.3% in 2021 compared to 2020, the number of deaths due to COVID-19 increased by 194.4% and the number of tests increased by 285.7%. In 2021, it is seen that there are serious increases in both the number of cases and the number of deaths compared to the figures of 2020. However, the case/death rates are gradually decreasing. Türkiye's case-based death rate was 9.45 per thousand in 2020, 8.4 per thousand in 2021 and 2.93 per thousand according to the data until July 2022. The top five countries reporting the most cases; USA, India, Brazil, France and Germany. Among the top 20 countries reporting the highest number of cases, the countries with the highest mortality rate due to the case (per thousand); Mexico 52.10, Indonesia 25.64, Colombia 22.62, Russia 20.67, Brazil 20.49, Iran 19.51 , Argentina 13.70, India 12.04 and the USA 11.55 per thousand. While the case-related death rate in the world was 20.84 per thousand in 2021, this rate was 11.45 per thousand as of July 2022. Although the number of cases due to COVID-19 has increased worldwide, it is seen that the death rate has decreased. In Turkey, the death rate per case is 6.52 per thousand. We can say that the health infrastructure is strong and the policies implemented are effective in the fight against COVID-19 in Türkiye.
{"title":"EVALUATION OF TÜRKİYE'S COVID-19 DATA AND THE STATUS IN THE WORLD","authors":"Ü. Arslan, Altuğ Çağatay","doi":"10.55433/gsbd.239","DOIUrl":"https://doi.org/10.55433/gsbd.239","url":null,"abstract":"In this study, COVID-19 data announced by the Ministry of Health (2020-2021) were analyzed and Türkiye's situation in the world was evaluated by comparing it with other countries according to the World Health Organization data. The number of COVID-19 cases in Türkiye increased by 229.3% in 2021 compared to 2020, the number of deaths due to COVID-19 increased by 194.4% and the number of tests increased by 285.7%. In 2021, it is seen that there are serious increases in both the number of cases and the number of deaths compared to the figures of 2020. However, the case/death rates are gradually decreasing. Türkiye's case-based death rate was 9.45 per thousand in 2020, 8.4 per thousand in 2021 and 2.93 per thousand according to the data until July 2022. The top five countries reporting the most cases; USA, India, Brazil, France and Germany. Among the top 20 countries reporting the highest number of cases, the countries with the highest mortality rate due to the case (per thousand); Mexico 52.10, Indonesia 25.64, Colombia 22.62, Russia 20.67, Brazil 20.49, Iran 19.51 , Argentina 13.70, India 12.04 and the USA 11.55 per thousand. While the case-related death rate in the world was 20.84 per thousand in 2021, this rate was 11.45 per thousand as of July 2022. Although the number of cases due to COVID-19 has increased worldwide, it is seen that the death rate has decreased. In Turkey, the death rate per case is 6.52 per thousand. We can say that the health infrastructure is strong and the policies implemented are effective in the fight against COVID-19 in Türkiye.","PeriodicalId":422894,"journal":{"name":"GOBEKLİTEPE Saglik Bilimleri Dergisi","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128483661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gozdenur Tanrikulu, Sibel Küçükoğlu, Fatma Taş Arslan
Covid-19 has emerged as a serious public health emergency and has started a process that requires an urgent response. Although Covid-19 is a disease that causes higher mortality and morbidity in adults, it has been seen to affect children as well. While children play an important role in the transmission of Covid-19 infection and epidemic dynamics, they constitute a key target population for effective measures to control these outbreaks. In this direction, it was concluded that the planning and implementation of Covid-19 vaccines should include children in increasing immunity rates. Due to the fact that the Covid-19 vaccine is new and the trials on children continue, it has been observed that these conditions affect the vaccination intention of the parents. The fact that anti-vaccine and vaccine hesitancy has become an increasing problem all over the world, including in our country, has also affected the rate of Covid-19 vaccination. Healthcare workers play a key role in tackling negative attitudes towards Covid-19 vaccination. Health professionals may have responsibilities such as vaccine development, vaccine information and application, following up-to-date information about vaccine side effects, determining parents' intentions regarding their children's Covid-19 vaccine, and informing parents about Covid-19 vaccines. In this rewiew the Covid-19 pandemic in children, the Covid 19 vaccine applications, the role of parents and healthcare professionals have been compiled.
{"title":"VACCINATION APPLICATIONS FROM THE PERSPECTIVE OF COVID-19 IN CHILDREN AND THE ROLE OF HEALTHCARE PROFESSIONALS SICK A TRADITIONAL REVIEW","authors":"Gozdenur Tanrikulu, Sibel Küçükoğlu, Fatma Taş Arslan","doi":"10.55433/gsbd.167","DOIUrl":"https://doi.org/10.55433/gsbd.167","url":null,"abstract":"Covid-19 has emerged as a serious public health emergency and has started a process that requires an urgent response. Although Covid-19 is a disease that causes higher mortality and morbidity in adults, it has been seen to affect children as well. While children play an important role in the transmission of Covid-19 infection and epidemic dynamics, they constitute a key target population for effective measures to control these outbreaks. In this direction, it was concluded that the planning and implementation of Covid-19 vaccines should include children in increasing immunity rates. Due to the fact that the Covid-19 vaccine is new and the trials on children continue, it has been observed that these conditions affect the vaccination intention of the parents. The fact that anti-vaccine and vaccine hesitancy has become an increasing problem all over the world, including in our country, has also affected the rate of Covid-19 vaccination. Healthcare workers play a key role in tackling negative attitudes towards Covid-19 vaccination. Health professionals may have responsibilities such as vaccine development, vaccine information and application, following up-to-date information about vaccine side effects, determining parents' intentions regarding their children's Covid-19 vaccine, and informing parents about Covid-19 vaccines. In this rewiew the Covid-19 pandemic in children, the Covid 19 vaccine applications, the role of parents and healthcare professionals have been compiled.","PeriodicalId":422894,"journal":{"name":"GOBEKLİTEPE Saglik Bilimleri Dergisi","volume":"90 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115019739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Factors related to treatment adherence in patients with schizophrenia have always been key to the treatment of these patients. The aim of this study is to determination of treatment adherence and ıts influencing factors in patients with schizophrenia. This is a descriptive phenomenology study. The research was conducted with 15 patients, between October 2018 and January 2019. Participants in the research were selected by purposive sampling. Data collection was by the face-to-face interview technique. A personal information form and a semi-structured interview form were used to collect data. The mean age of the sample was 44.9 ± 7.2. 80% were male and 53.3% were secondery school graduates. As a result of the coding, 4 themes were determined. It is concluded that the continuation of community mental health centers schizophrenia patients contributes positively to their adaptation. It is important that determination of the affecting factors of treatment adherence by nurses and working with patient to improve treatment adherence.
{"title":"THE DETERMINATION OF FACTORS AFFECTING MEDICATION ADHERENCE IN PATIENTS WITH SCHIZOPHRENIA: A QUALITATIVE STUDY","authors":"M. Meriç, G. Ergün","doi":"10.55433/gsbd.211","DOIUrl":"https://doi.org/10.55433/gsbd.211","url":null,"abstract":"Factors related to treatment adherence in patients with schizophrenia have always been key to the treatment of these patients. The aim of this study is to determination of treatment adherence and ıts influencing factors in patients with schizophrenia. This is a descriptive phenomenology study. The research was conducted with 15 patients, between October 2018 and January 2019. Participants in the research were selected by purposive sampling. Data collection was by the face-to-face interview technique. A personal information form and a semi-structured interview form were used to collect data. The mean age of the sample was 44.9 ± 7.2. 80% were male and 53.3% were secondery school graduates. As a result of the coding, 4 themes were determined. It is concluded that the continuation of community mental health centers schizophrenia patients contributes positively to their adaptation. It is important that determination of the affecting factors of treatment adherence by nurses and working with patient to improve treatment adherence.","PeriodicalId":422894,"journal":{"name":"GOBEKLİTEPE Saglik Bilimleri Dergisi","volume":"91 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121553675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cross-linked enzymes are more stable at a certain temperature than free enzymes. Bovine serum albumin (BSA), which has a large number of amine groups, provides a strong binding between enzyme aggregates, thus leading to increased activity and stability of the bioactive layer. The enzyme-BSA mixture becomes more stable after covalent bonding with a crosslinking agent such as glutaraldehyde. The HRP enzyme was immobilized on the gold electrode together with BSA, gelatin and glutaraldehyde with the help of UV light. Four different electrodes were prepared using different amounts of BSA at 7.5 mg, 15 mg, 30 mg and 60 mg concentrations for each electrode Using four different electrodes prepared, 16 electrochemical measurements were performed with four different ferrous iron analytes. Glutaraldehyde binds to the BSA polymer, which has a higher affinity than the enzyme, reducing the tight covalent cross-links caused by BSA on the HRP and ensuring the continuation of the enzyme activity. It was observed that different BSA concentrations significantly affected the enzyme activity. The concentration of polymers to be used for crosslinking enzymes is an important factor in electrochemical studies.
{"title":"HYDROGEN PEROXIDASE ENZYME ACTIVITY AT DIFFERENT CONCENTRATIONS OF BSA","authors":"A. İlhan, U. Kökbaş, L. Kayrın","doi":"10.55433/gsbd.164","DOIUrl":"https://doi.org/10.55433/gsbd.164","url":null,"abstract":"Cross-linked enzymes are more stable at a certain temperature than free enzymes. Bovine serum albumin (BSA), which has a large number of amine groups, provides a strong binding between enzyme aggregates, thus leading to increased activity and stability of the bioactive layer. The enzyme-BSA mixture becomes more stable after covalent bonding with a crosslinking agent such as glutaraldehyde. The HRP enzyme was immobilized on the gold electrode together with BSA, gelatin and glutaraldehyde with the help of UV light. Four different electrodes were prepared using different amounts of BSA at 7.5 mg, 15 mg, 30 mg and 60 mg concentrations for each electrode Using four different electrodes prepared, 16 electrochemical measurements were performed with four different ferrous iron analytes. Glutaraldehyde binds to the BSA polymer, which has a higher affinity than the enzyme, reducing the tight covalent cross-links caused by BSA on the HRP and ensuring the continuation of the enzyme activity. It was observed that different BSA concentrations significantly affected the enzyme activity. The concentration of polymers to be used for crosslinking enzymes is an important factor in electrochemical studies.","PeriodicalId":422894,"journal":{"name":"GOBEKLİTEPE Saglik Bilimleri Dergisi","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131378047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Grape is a perennial plant and its fruit and leaves are consumed as food. Its homeland is thought to be the Middle East. There is evidence that the cultivation of this plant began 7-8 thousand years ago. When we look at the content of ripe grapes, 100 grams of grapes contain 69 kilos of energy, 81% of them are water, 18% are carbohydrates, 1% is protein, and contain very little fat, vitamin K and vitamin E. Resveratrol (RSV) was first produced in the early 1930s by the medicinal plant Veratrum grandifolium Loes. fil., many studies have shown that it will be useful in clinical use due to the flavonoids and polyphenolic compounds found in grapes. RSV is a natural non-flavonoid polyphenol belonging to the stilbenoid group, especially found in the skin of black grapes. Besides grapes, it is also found in various plants such as strawberries, blueberries, pomegranates, mulberries, pistachios and peanuts. It is thought that RSV, which is found in dietary components, may have many effects such as antioxidant, anti-inflammatory, anticarcinogenic, neuroprotective, cardioprotective, lipid regulating, antidiabetic and life-prolonging. The potential benefits of RSV have been widely studied in some animal experiments, with positive results. Clinical trials in humans, on the other hand, are less numerous and the results are not yet conclusive. Considering the scientific studies done so far, it has been determined that RSV has tumor-suppressive properties in many stages of cancer. It is a powerful antioxidant that can prevent cell damage caused by free radicals. Radiotherapy or chemotherapy causes inflammation in neighboring cells of cancer cells, while RSV stimulates leukocytes to eliminate these lysed cells, thereby accelerating their apoptosis. RSV improves lipid profile by reducing hepatic 3-hydroxy-3-methyl-glutaryl-CoA reductase in mRNA expression and potentially leading to reverse cholesterol transport. It has been shown that it can lower blood pressure by increasing endothelial nitric oxide (NO) production, reducing oxidative damage and calcium influx. While RSV does not cause any changes in blood pressure acutely, when used for a long time, it improves endothelial function, especially in hypertensive women with higher LDL cholesterol levels. Because polyphenols reduce atherogenesis by preventing low-density lipoprotein oxidation, fat accumulation and platelet aggregation. Down-regulation of inflammatory pathways and regular signaling, decrease in IL-6, TNF alpha, interferon-gamma, Herp, IL-8 and leptin levels, down-regulation of leukocyte adhesion molecules, changes in mRNAs involved in inflammatory modulation, anti-inflammatory effect through an increase in IL-10 plasma levels shows. Recent studies have shown that RSV has a curative effect on Alzheimer's disease and prevents neurological damage in case of cerebral ischemia. It has a protective effect against chronic obstructive pulmonary disease. Some recent studies on RSV have determined that it prolo
{"title":"EFFECTS OF RESVERATROL ON HUMAN HEALTH","authors":"Rumeysa Duyuran, H. Cicek, Baran Bincan","doi":"10.55433/gsbd.189","DOIUrl":"https://doi.org/10.55433/gsbd.189","url":null,"abstract":"Grape is a perennial plant and its fruit and leaves are consumed as food. Its homeland is thought to be the Middle East. There is evidence that the cultivation of this plant began 7-8 thousand years ago. When we look at the content of ripe grapes, 100 grams of grapes contain 69 kilos of energy, 81% of them are water, 18% are carbohydrates, 1% is protein, and contain very little fat, vitamin K and vitamin E. Resveratrol (RSV) was first produced in the early 1930s by the medicinal plant Veratrum grandifolium Loes. fil., many studies have shown that it will be useful in clinical use due to the flavonoids and polyphenolic compounds found in grapes. RSV is a natural non-flavonoid polyphenol belonging to the stilbenoid group, especially found in the skin of black grapes. Besides grapes, it is also found in various plants such as strawberries, blueberries, pomegranates, mulberries, pistachios and peanuts. It is thought that RSV, which is found in dietary components, may have many effects such as antioxidant, anti-inflammatory, anticarcinogenic, neuroprotective, cardioprotective, lipid regulating, antidiabetic and life-prolonging. The potential benefits of RSV have been widely studied in some animal experiments, with positive results. Clinical trials in humans, on the other hand, are less numerous and the results are not yet conclusive. Considering the scientific studies done so far, it has been determined that RSV has tumor-suppressive properties in many stages of cancer. It is a powerful antioxidant that can prevent cell damage caused by free radicals. Radiotherapy or chemotherapy causes inflammation in neighboring cells of cancer cells, while RSV stimulates leukocytes to eliminate these lysed cells, thereby accelerating their apoptosis. RSV improves lipid profile by reducing hepatic 3-hydroxy-3-methyl-glutaryl-CoA reductase in mRNA expression and potentially leading to reverse cholesterol transport. It has been shown that it can lower blood pressure by increasing endothelial nitric oxide (NO) production, reducing oxidative damage and calcium influx. While RSV does not cause any changes in blood pressure acutely, when used for a long time, it improves endothelial function, especially in hypertensive women with higher LDL cholesterol levels. Because polyphenols reduce atherogenesis by preventing low-density lipoprotein oxidation, fat accumulation and platelet aggregation. Down-regulation of inflammatory pathways and regular signaling, decrease in IL-6, TNF alpha, interferon-gamma, Herp, IL-8 and leptin levels, down-regulation of leukocyte adhesion molecules, changes in mRNAs involved in inflammatory modulation, anti-inflammatory effect through an increase in IL-10 plasma levels shows. Recent studies have shown that RSV has a curative effect on Alzheimer's disease and prevents neurological damage in case of cerebral ischemia. It has a protective effect against chronic obstructive pulmonary disease. Some recent studies on RSV have determined that it prolo","PeriodicalId":422894,"journal":{"name":"GOBEKLİTEPE Saglik Bilimleri Dergisi","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131678682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tuba Koç Özkan, Ç. Erdemoğlu, I. Turan, Semiha Aydın Özkan
The aim of this study is to determine the relationship between premenstrual syndrome symptoms and eating attitudes in adolescents. Materials and Methods: In this study, which was conducted in correlational research type, data were obtained from 250 adolescents between the ages of 15-21. Data were collected via an online questionnaire. Personal Information Form, Premenstrual Syndrome Scale and Eating Attitude Test Short Form were used as data collection tools. Descriptive statistics and Pearson correlation analysis were used to evaluate the research data.. Results: it was determined that the total mean score of the Premenstrual Syndrome scale of the adolescents was 44.34±39.74, and the mean total score of the EAT was 13.41±10.00. It was determined that 79.6% of the adolescents participating in the study had positive premenstrual syndrome symptoms, and 20.4% had an eating attitude disorder. Eating attitude disorder was found to be statistically significant in 23.1% of adolescents with positive premenstrual syndrome symptoms (X2=4.430, p=.035). It was determined that as the premenstrual syndrome scale score of the adolescents increased, the scores of the eating attitude test increased, and there was a weak positive correlation between them (r=.181, p=.004). Conclusion: In the study, it was determined that there is a weak positive relationship between premenstrual syndrome and eating attitudes in adolescents, and 23.1% of adolescents who experience premenstrual syndrome symptoms have eating attitude disorders. Regulation of eating habits will be effective in improving the quality of life and general health of adolescents who experience premenstrual syndrome symptoms.
{"title":"THE RELATIONSHIP BETWEEN PREMENSTRUAL SYNDROME SYMPTOMS AND EATING ATTITUDES IN ADOLESCENTS","authors":"Tuba Koç Özkan, Ç. Erdemoğlu, I. Turan, Semiha Aydın Özkan","doi":"10.55433/gsbd.192","DOIUrl":"https://doi.org/10.55433/gsbd.192","url":null,"abstract":"The aim of this study is to determine the relationship between premenstrual syndrome symptoms and eating attitudes in adolescents. Materials and Methods: In this study, which was conducted in correlational research type, data were obtained from 250 adolescents between the ages of 15-21. Data were collected via an online questionnaire. Personal Information Form, Premenstrual Syndrome Scale and Eating Attitude Test Short Form were used as data collection tools. Descriptive statistics and Pearson correlation analysis were used to evaluate the research data.. Results: it was determined that the total mean score of the Premenstrual Syndrome scale of the adolescents was 44.34±39.74, and the mean total score of the EAT was 13.41±10.00. It was determined that 79.6% of the adolescents participating in the study had positive premenstrual syndrome symptoms, and 20.4% had an eating attitude disorder. Eating attitude disorder was found to be statistically significant in 23.1% of adolescents with positive premenstrual syndrome symptoms (X2=4.430, p=.035). It was determined that as the premenstrual syndrome scale score of the adolescents increased, the scores of the eating attitude test increased, and there was a weak positive correlation between them (r=.181, p=.004). Conclusion: In the study, it was determined that there is a weak positive relationship between premenstrual syndrome and eating attitudes in adolescents, and 23.1% of adolescents who experience premenstrual syndrome symptoms have eating attitude disorders. Regulation of eating habits will be effective in improving the quality of life and general health of adolescents who experience premenstrual syndrome symptoms.","PeriodicalId":422894,"journal":{"name":"GOBEKLİTEPE Saglik Bilimleri Dergisi","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126482762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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