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Opto-electrochemical sensing of C-reactive protein using optical fiber lossy-mode resonance sensor 光纤损耗模谐振传感器对c反应蛋白的光电电化学传感
Pub Date : 2023-05-23 DOI: 10.1117/12.2678113
D. Burnat, K. Szot-Karpińska, P. Sezemský, M. Janik, M. Koba, J. Niedziółka-Jönsson, Viteszlav Stranak, M. Śmietana
This work describes an experimental study towards label-free sensing of C-reactive protein (CRP) – a protein recognized as a inflammation marker. A multimode optical fiber with a section of its core coated with indium tin oxide (ITO) thin film was used as a sensor. ITO film allows for guiding lossy modes and can simultaneously be used as a transparent electrode for electrochemical measurements. Therefore, optical and electrochemical detection based on a single sensor was possible. Such a dual-domain approach is practical, especially when the results in one of the domains are not accurate enough, which was the case in this work. A case of different functionalization methods of ITO surface was also pointed out. The proposed sensor allows for recognition as low as ng/mL.
这项工作描述了一项对c反应蛋白(CRP)无标记传感的实验研究-一种被认为是炎症标志物的蛋白质。采用一种芯部部分包覆氧化铟锡薄膜的多模光纤作为传感器。ITO薄膜允许引导损耗模式,可以同时用作电化学测量的透明电极。因此,基于单个传感器的光学和电化学检测是可能的。这种双领域方法是实用的,特别是当其中一个领域的结果不够准确时,这就是本工作的情况。并列举了ITO表面不同功能化方法的实例。所提出的传感器允许识别低至ng/mL。
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引用次数: 0
A probe-type fiber optic ultraviolet photodetector 一种探针型光纤紫外光电探测器
Pub Date : 2023-05-23 DOI: 10.1117/12.2681883
Yue Qin, Dingbang Ma, Y. Wang, C. Liao, Yiping Wang
A probe-type all-fiber ultraviolet photodetector is proposed in this paper. A ZnO microwire is fixed on the end facet of a single-mode fiber through a glass tube with specific diameter to form a Fabry-Pérot interferometer. With this all-fiber structure, fast-response ultraviolet detection can be realized in an all-optical scheme. Since the refractive index of ZnO microwire increases under the illumination of ultraviolet, interference wavelengths of abovementioned device redshifts with the increase of ultraviolet light intensity. By employing a continuous 266-nm laser beam and chopping method, the sensitivity is obtained to be 0.268 nm/(W·cm-2 ) and the response time is only 0.56 ms. To be more specifically, the response speed of the device is further explored by a 266-nm pulsed laser, and the response time of the device is measured to be only 13 μs. The proposed device provides a new idea for the next generation of high-performance ultraviolet photodetectors and may find potential applications in the future.
提出了一种探针型全光纤紫外探测器。将氧化锌微丝通过特定直径的玻璃管固定在单模光纤的端面上,形成法布里-普氏干涉仪。利用这种全光纤结构,可以在全光方案下实现快速响应紫外检测。由于紫外光照射下ZnO微线的折射率增大,上述器件的干涉波长随着紫外光强度的增加而红移。采用266 nm连续激光束和斩波方法,获得了0.268 nm/(W·cm-2)的灵敏度,响应时间仅为0.56 ms。具体来说,利用266 nm脉冲激光进一步探索了器件的响应速度,测量到器件的响应时间仅为13 μs。所提出的器件为下一代高性能紫外探测器提供了新的思路,并可能在未来找到潜在的应用前景。
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引用次数: 0
Dual functionality of wavelength scanning coherent optical time domain reflectometer 波长扫描相干光时域反射计的双重功能
Pub Date : 2023-05-23 DOI: 10.1117/12.2678098
Xin Lu, K. Hicke, K. Krebber
Wavelength scanning coherent optical time domain reflectometer (WS-COTDR) is a good candidate to spatially resolve the environmental information at comparatively low frequency. This paper reveals it can also work as a traditional optical time domain reflectometer (OTDR) to identify Fresnel reflection by averaging the obtained signal over the wavelength scanning range. Simultaneous distributed vibration sensing and a traditional OTDR measurement are experimentally demonstrated using the WS-COTDR system.
波长扫描相干光时域反射计(WS-COTDR)是较低频率环境信息空间解析的理想选择。本文揭示了它也可以作为传统的光学时域反射计(OTDR),通过在波长扫描范围内平均获得的信号来识别菲涅耳反射。利用WS-COTDR系统对分布式振动传感和传统OTDR测量同时进行了实验验证。
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引用次数: 0
Directional bending monitoring using a multimode elliptical-core fiber and a machine learning algorithm 利用多模椭圆芯光纤和机器学习算法进行定向弯曲监测
Pub Date : 2023-05-23 DOI: 10.1117/12.2678451
Rodolfo Martínez-Manuel, Jonathan Esquivel-Hernández, Luis M. Valentín-Coronado, M. Shlyagin, S. Larochelle
An approach for directional bending monitoring based on a multimode fiber and a machine learning algorithm is presented. The sensor if formed by splicing a single mode fiber to a multimode elliptical-core fiber. Using this elliptical-core fiber, multimode interference generates an interferogram with non-uniform amplitude and non-periodic shape. These characteristics are important to process the sensing signal using a machine learning algorithm. The machine learning algorithm implemented is the well-known random forest algorithm. In the reported experiments, the fiber is bended in different directions and different magnitudes of bending, generating a specific interferogram in each position, then each bending position is identified by the random forest algorithm. Once the position is identified, the trajectory of the sensor can be calculated. Experimental demonstration for directional bending monitoring, based on a machine learning algorithm, is presented.
提出了一种基于多模光纤和机器学习算法的定向弯曲监测方法。该传感器由单模光纤与多模椭圆芯光纤拼接而成。利用这种椭圆芯光纤,多模干涉产生非均匀振幅和非周期形状的干涉图。这些特征对于使用机器学习算法处理传感信号非常重要。实现的机器学习算法是众所周知的随机森林算法。在实验中,对光纤进行不同方向和不同弯曲幅度的弯曲,在每个位置产生特定的干涉图,然后通过随机森林算法识别每个弯曲位置。一旦确定了位置,就可以计算传感器的轨迹。给出了一种基于机器学习算法的定向弯曲监测实验演示。
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引用次数: 0
Tilted optical fiber Bragg grating with fluorinated graphene-like overlayer for ammonia detection 含氟石墨烯涂层的倾斜光纤布拉格光栅用于氨检测
Pub Date : 2023-05-23 DOI: 10.1117/12.2678525
E. Grantzioti, N. Samartzis, K. Bhorkar, S. Pissadakis, S. Yannopoulos, M. Konstantaki
We describe an optical fiber sensor for detection of ammonia vapors employing a fluorinated graphene-like overlayer on a tilted Bragg grating. Exploiting the laser-mediated explosive synthesis and transfer (LEST) of graphene (Gr) flakes a thin film of few-layer turbostratic graphene flakes doped with F atoms (~ 3.3 at. %) are deposited on the fiber at the location of the grating. The response of the sensor was investigated for NH4OH vapors while for reference, the effect of H2O was also monitored at identical conditions. Under increasing vapor pressure of NH4OH, wavelength shift is recorded not only in the cladding modes but also for the fundamental Bragg mode, indicating that the effect is not solely due to changes in the optical parameters of the overlayer. The monitored wavelength shift is initially negative turning to positive when vapor saturation is reached. Furthermore, there is a distinct difference in the magnitude of the monitored shifts with the higher order mode exhibiting 2.5x higher values compared to the Bragg mode. The study is ongoing and will also include overlayers of pure LEST Gr and LEST Gr decorated with Six nanoparticles.
我们描述了一种用于检测氨蒸气的光纤传感器,该传感器在倾斜的布拉格光栅上采用氟化石墨烯样覆盖层。利用激光介导的石墨烯(Gr)片的爆炸合成和转移(LEST),制备了掺杂F原子(~ 3.3 at)的少层涡轮层石墨烯片薄膜。%)沉积在光栅位置的光纤上。研究了传感器对NH4OH蒸气的响应,并在相同条件下监测了H2O的影响。在NH4OH蒸气压增加的情况下,不仅在包层模式中记录到了波长偏移,而且在基本布拉格模式中也记录到了波长偏移,这表明这种影响不仅仅是由于包层光学参数的变化。当达到蒸汽饱和时,监测到的波长位移最初是负的,变为正的。此外,与布拉格模式相比,高阶模式的监测位移的幅度有明显的差异,显示出2.5倍的高值。这项研究仍在进行中,还将包括用六种纳米粒子装饰纯的纳米级和纳米级的纳米级。
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引用次数: 0
Optical fiber probe for prostate cancer screening: ex vivo study 光纤探头用于前列腺癌筛查:离体研究
Pub Date : 2023-05-23 DOI: 10.1117/12.2678083
A. Iele, A. Ricciardi, C. Pecorella, A. Cirillo, F. Ficuciello, B. Siciliano, R. La Rocca, V. Mirone, M. Consales, A. Cusano
We developed a miniaturized optical probe, based on a customized Fiber Bragg Grating, for mechanical characterization of biological tissues with sub-millimeter spatial resolution. The probe is integrated inside a metallic cannula (16 gauge) used for clinical applications, and it is driven by a robotic arm (KUKA LBR Med 7). The optical sensor has a resolution of less than 1 mN and measures the force on controlled tissue indentations. The functionality of the sensor was assessed by means of different tests carried out on real prostates obtained from radically surgeries of patients at different stages of the carcinoma (Gleason score from 6 to 8). Specifically, in this work, we demonstrate that our system provides results that are on line with to the biopsy analysis performed before and the surgery. Our findings lay the foundation for the development of compact optical fiber probes, with size compatible with needle/catheter, able to perform in vivo mechanical characterizations of the prostatic tissue with high sensitivity and spatial resolution.
我们开发了一种基于定制光纤布拉格光栅的小型化光学探针,用于亚毫米空间分辨率的生物组织力学表征。该探头集成在用于临床应用的金属套管(16号)内,由机械臂(KUKA LBR Med 7)驱动。光学传感器的分辨率小于1 mN,可测量受控制组织压痕上的力。传感器的功能是通过对不同阶段癌症患者进行根根性手术获得的真实前列腺进行的不同测试来评估的(Gleason评分从6到8)。具体来说,在这项工作中,我们证明了我们的系统提供的结果与术前和手术前进行的活检分析一致。我们的研究结果为紧凑型光纤探针的发展奠定了基础,其尺寸与针/导管兼容,能够以高灵敏度和空间分辨率进行前列腺组织的体内力学表征。
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引用次数: 0
Draw tower furnace diagnostics applying a sapphire fiber Bragg grating probe 应用蓝宝石光纤布拉格光栅探头进行拉塔炉诊断
Pub Date : 2023-05-23 DOI: 10.1117/12.2679822
T. Elsmann, A. Lorenz, K. Schröder, T. Habisreuther
Sapphire fiber Bragg gratings (SFBG) were used for temperature diagnosis of a commercial inductive heated furnace of a fiber draw tower. In a fiber preform temperature gradients > 10K/mm were detected. In the temperature range from 1000°C to 1900°C the measured temperature inside the furnace is about 140K below the control temperature detected by a pyrometer on a spot of the heating element. The dependence of applied temperature on the furnace heating power was derived that can allow furnace control without pyrometer and therefore extending operation range below 1000°C. No degradation of SFBG was observed.
采用蓝宝石光纤布拉格光栅(SFBG)对光纤拉丝塔商用感应加热炉进行了温度诊断。在纤维预制体中检测到温度梯度> 10K/mm。在1000°C到1900°C的温度范围内,炉内的测量温度比加热元件上一个点的高温计检测到的控制温度低140K左右。应用温度对炉膛加热功率的依赖性得到了推导,可以在没有高温计的情况下控制炉膛,从而将工作范围扩展到1000°C以下。未观察到SFBG的降解。
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引用次数: 0
Sub-centimeter spatial resolution dynamic strain sensing using time-expanded ΦOTDR 基于时间扩展的亚厘米空间分辨率动态应变传感ΦOTDR
Pub Date : 2023-05-23 DOI: 10.1117/12.2678093
M. Soriano-Amat, P. Guay, H. Martins, S. Martín-López, M. González-Herráez, J. Genest, M. Fernández-Ruiz
Time-expanded phase-sensitive (TE-φ )OTDR is a distributed optical fiber sensing (DOFS) technique that takes advantage of the dual-frequency comb technology to offer distributed, dynamic, and high-spatial resolution measurements. The performance delivered by this recent approach is unmatched by any other DOFS, combining the high resolution of OFDR with the potential for long range and fast sampling of φ OTDR. In this contribution, we present an optimized TE-φ OTDR scheme with important improvements with respect to the traditional one. In particular, the new architecture uses electrooptical phase modulation instead of intensity modulation, increasing the energy-efficiency. Additionally, it employs an optical hybrid to double the spectral efficiency of the system, which in practical terms results in doubling the spatial resolution for the same interrogating comb bandwidth. The proposed architecture has been experimentally validated through a scheme providing 5 mm of spatial resolution, 80 m of range and 70 Hz sampling rate with a simple, compact and low-cost setup using field-programmable gate arrays (FPGA) and relatively low bandwidth photodetection (2 MHz).
时间扩展相敏(TE-φ)OTDR是一种分布式光纤传感(DOFS)技术,它利用双频梳技术提供分布式、动态和高空间分辨率的测量。这种最新方法提供的性能是任何其他dfs无法比拟的,它结合了OFDR的高分辨率和φ OTDR的长距离和快速采样的潜力。在这篇文章中,我们提出了一个优化的TE-φ OTDR方案,与传统方案相比有重要的改进。特别是,新架构使用电光相位调制而不是强度调制,提高了能源效率。此外,它还采用了光学混合技术,使系统的频谱效率提高了一倍,在实际中,在相同的询问梳带宽下,空间分辨率提高了一倍。所提出的架构已经通过一个方案进行了实验验证,该方案提供5 mm的空间分辨率,80 m的范围和70 Hz的采样率,采用现场可编程门阵列(FPGA)和相对低带宽的光电探测(2 MHz),简单,紧凑和低成本的设置。
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引用次数: 0
Lab-on-fiber optrodes based on all-dielectric fluorescence enhancing metasurfaces 基于全介电荧光增强超表面的光纤光电电极
Pub Date : 2023-05-23 DOI: 10.1117/12.2679369
H. Alhalaby, M. Principe, H. Zaraket, P. Vaiano, A. Aliberti, G. Quero, A. Crescitelli, V. Di Meo, E. Esposito, M. Consales, A. Cusano
The need for miniaturized biological sensors which can be easily integrated into medical needles and catheters for in vivo liquid biopsies with ever-increasing performances has stimulated the interest of researchers in Lab-on-Fiber (LOF) technology. In this framework, the integration of Metasurfaces (MSs) on the tip of the optical fiber (Optical Fiber Meta- Tip, OFMT) has represented a major breakthrough. Indeed, we showed that a suitably designed plasmonic OFMT biosensor significantly outperforms standard plasmonic ones due to the advanced light wave manipulation of MSs. Here, to further improve the sensing performances, we propose a novel class of LOF optrodes for labelled biosensing based on dielectric fluorescence enhancing OFMT. We envision a single fiber probe with integrated a Silicon MS on its tip as a light coupled substrate that illuminates the sample and simultaneously collects the enhanced emission from the dye molecules labeling the biological target. We present a numerical environment to compute the fluorescence enhancement factor collected by a multi-mode-fiber, when on its tip a Silicon MS is laid, consisting of an array of cylindrical nanoantennas. According to the numerical results, a suitable design of the dielectric MS allows for a fluorescence enhancement up to three orders of magnitudes. Moreover, a feasibility study is carried out to verify the possibility to fabricate the designed MSs on the termination of multimode optical fibers using electron beam lithography followed by reactive ion etching. This work provides the main guidelines for the development of advanced LOF devices based on the fluorescence enhancement for labeled biosensing.
对小型化生物传感器的需求激发了研究人员对光纤实验室(LOF)技术的兴趣,这种传感器可以很容易地集成到医用针头和导管中,用于体内液体活检,并且性能不断提高。在这个框架中,光纤尖端的元表面(MSs)的集成(光纤元端,OFMT)代表了一个重大突破。事实上,我们证明了一个适当设计的等离子体OFMT生物传感器明显优于标准等离子体OFMT生物传感器,这是由于MSs先进的光波操纵。在这里,为了进一步提高传感性能,我们提出了一种基于介电荧光增强OFMT的新型LOF光电极用于标记生物传感。我们设想一种单纤维探针,其尖端集成了硅质谱,作为光耦合衬底,照亮样品,同时收集标记生物目标的染料分子的增强发射。我们提出了一个计算多模光纤收集的荧光增强因子的数值环境,当在其尖端铺设由圆柱形纳米天线阵列组成的硅质谱时。根据数值结果,一个合适的介电质谱设计允许荧光增强高达三个数量级。此外,还进行了可行性研究,验证了采用电子束光刻和反应离子刻蚀技术在多模光纤端部制备所设计的多模光纤端部微结构的可能性。这项工作为基于荧光增强的标记生物传感先进LOF器件的开发提供了主要指导。
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引用次数: 0
Damage detection in an aluminum plate through a phi-OTDR sensor and support vector machines 基于pi - otdr传感器和支持向量机的铝板损伤检测
Pub Date : 2023-05-23 DOI: 10.1117/12.2678095
R. Zahoor, E. Catalano, R. Vallifuoco, L. Zeni, A. Minardo
In this paper, we make use of a phase-sensitive time domain reflectometry (phi-OTDR) sensor with 60-cm spatial resolution to detect the Lamb waves generated by a piezo-ceramic actuator in an aluminum plate. Furthermore, a machine learning algorithm based on Support Vector Machine (SVM) classifiers was employed for damage localization. We show that SVMs are able to identify the characteristics in Lamb wave signals that may be linked to damage location. This study makes full use of the rich information provided by the phi-OTDR sensor, extracting damaged data from diverse damage spots. The results indicate that the proposed technique has the potential to identify and locate damages in thin-plate structures.
在本文中,我们利用60厘米空间分辨率的相敏时域反射(phi-OTDR)传感器来检测铝板中压电陶瓷致动器产生的兰姆波。在此基础上,采用基于支持向量机分类器的机器学习算法进行损伤定位。我们表明支持向量机能够识别可能与损伤位置相关的Lamb波信号中的特征。本研究充分利用了phi-OTDR传感器提供的丰富信息,从不同的损伤点提取损伤数据。结果表明,该方法具有识别和定位薄板结构损伤的潜力。
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引用次数: 0
期刊
European Workshop on Optical Fibre Sensors
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