Psoriasis is a common chronic inflammatory and proliferative condition of the skin and its presentation as targetoid lesions has not been described. A 29-year-old male came to the outpatient department with multiple red color elevated skin lesions over the forehead and trunk for the past 10 days. Multiple targetoid lesions of size 2 cm × 2 cm to 5 cm × 4 cm having central edematous crusted zone and the peripheral zone of erythema with irregular to well-defined margins present almost all over the body. Differential diagnosis included psoriasis, erythema multiforme, pemphigus erythematosus, and reiter's disease. The biopsy confirmed the diagnosis of psoriasis. The patient was started on injection methotrexate and responded well.
{"title":"Psoriasis presenting as targetoid lesions: First of its kind","authors":"Pallavi Goyal, S. Dayal, P. Sahu","doi":"10.4103/TJD.TJD_41_20","DOIUrl":"https://doi.org/10.4103/TJD.TJD_41_20","url":null,"abstract":"Psoriasis is a common chronic inflammatory and proliferative condition of the skin and its presentation as targetoid lesions has not been described. A 29-year-old male came to the outpatient department with multiple red color elevated skin lesions over the forehead and trunk for the past 10 days. Multiple targetoid lesions of size 2 cm × 2 cm to 5 cm × 4 cm having central edematous crusted zone and the peripheral zone of erythema with irregular to well-defined margins present almost all over the body. Differential diagnosis included psoriasis, erythema multiforme, pemphigus erythematosus, and reiter's disease. The biopsy confirmed the diagnosis of psoriasis. The patient was started on injection methotrexate and responded well.","PeriodicalId":42454,"journal":{"name":"Turk Dermatoloji Dergisi-Turkish Journal of Dermatology","volume":"24 1","pages":"76 - 78"},"PeriodicalIF":0.1,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77235162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This review summarizes the novel and precious data on the direct effects of ancient neuroendocrinologic molecules on the skin and hair and additionally the active production of these hormones by resident skin cells. The data are extracted from PubMed using the keywords neuroendocrinology, hormones, skin, hair follicle, pituitary, hypothalamus, thyroid, and prolactin. The most important neuroendocrinologic axis is composed of corticotropin-releasing hormone, adrenocorticotropic hormone, and cortisol (CRH–ACTH–cortisol) and is related to stress. The CRH–ACTH–cortisol axis is demonstrated to be fully functional in the skin. This review furthermore points out to a possible neuroendocrinologic mechanism likely to explain the association between psychological stress and skin and hair diseases.
{"title":"Brain–skin connection: The contemporary perspective through neuroendocrinology","authors":"A. Botsalı, O. Köse","doi":"10.4103/tjd.tjd_44_19","DOIUrl":"https://doi.org/10.4103/tjd.tjd_44_19","url":null,"abstract":"This review summarizes the novel and precious data on the direct effects of ancient neuroendocrinologic molecules on the skin and hair and additionally the active production of these hormones by resident skin cells. The data are extracted from PubMed using the keywords neuroendocrinology, hormones, skin, hair follicle, pituitary, hypothalamus, thyroid, and prolactin. The most important neuroendocrinologic axis is composed of corticotropin-releasing hormone, adrenocorticotropic hormone, and cortisol (CRH–ACTH–cortisol) and is related to stress. The CRH–ACTH–cortisol axis is demonstrated to be fully functional in the skin. This review furthermore points out to a possible neuroendocrinologic mechanism likely to explain the association between psychological stress and skin and hair diseases.","PeriodicalId":42454,"journal":{"name":"Turk Dermatoloji Dergisi-Turkish Journal of Dermatology","volume":"11 1","pages":"29 - 34"},"PeriodicalIF":0.1,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88497637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acquired Macular Hyperpigmentation: Ashy dermatosis (AD), lichen planus pigmentosus (LPP), erythema dyschromicum perstans (EDP), and idiopathic eruptive macular pigmentation (IEMP) are the spectrum of acquired macular pigmentation of unknown etiology (MPUE). The aim of this study is to investigate and reevaluate our pediatric patients who had clinically and histopathologically been diagnosed with aforementioned disorders, in consideration of the global consensus statement on acquired MPUE. Materials and Methods: A retrospective chart review of 23 pediatric cases that had applied to the dermatology unit between the years 2007 and 2017 and diagnosed with any of the acquired macular pigmentation was performed. Results: Of 23 patients, 16 were diagnosed with AD, 4 with LPP, and 3 with IEMP. In AD patients, major site of presentation at onset was the trunk (13/16) and brownish (15/16) were the most prominent coloring. Dermal melanophages (16/16), perivascular lymphohistiocytic infiltrate (14/16), and pigment incontinence (7/16) were the most prominent features. Upper limbs (3/4) were the most predilection area in LPP patients. Perivascular lymphohistiocytic (4/4), lichenoid infiltration (3/4), basal vacuolar degeneration (4/4), and dermal melanophages (4/4) were observed. The trunk was the major site of presentation (3/3) in IEMP patients. Brownish (2/3) and ashen-gray (1/3) was the coloring of lesions. Basal layer pigmentation (3/3) and dermal melanophages (3/3) were the most prominent findings. No basal vacuolar changes (0/3) were observed. Conclusion: Clinical and histopathological distinction between these conditions is challenging. We reevaluated our patients in this context. We predict that we have achieved more accurate terminology with the global consensus statement. Such a terminology might allow that these disorders may be compared with a collective terminology in the literature.
{"title":"Confusing acquired macular pigmentation of unknown etiology in children: Retrospective analysis of 10 years in single tertiary center","authors":"Selcen Kundak, Y. Çakır","doi":"10.4103/tjd.tjd_3_20","DOIUrl":"https://doi.org/10.4103/tjd.tjd_3_20","url":null,"abstract":"Acquired Macular Hyperpigmentation: Ashy dermatosis (AD), lichen planus pigmentosus (LPP), erythema dyschromicum perstans (EDP), and idiopathic eruptive macular pigmentation (IEMP) are the spectrum of acquired macular pigmentation of unknown etiology (MPUE). The aim of this study is to investigate and reevaluate our pediatric patients who had clinically and histopathologically been diagnosed with aforementioned disorders, in consideration of the global consensus statement on acquired MPUE. Materials and Methods: A retrospective chart review of 23 pediatric cases that had applied to the dermatology unit between the years 2007 and 2017 and diagnosed with any of the acquired macular pigmentation was performed. Results: Of 23 patients, 16 were diagnosed with AD, 4 with LPP, and 3 with IEMP. In AD patients, major site of presentation at onset was the trunk (13/16) and brownish (15/16) were the most prominent coloring. Dermal melanophages (16/16), perivascular lymphohistiocytic infiltrate (14/16), and pigment incontinence (7/16) were the most prominent features. Upper limbs (3/4) were the most predilection area in LPP patients. Perivascular lymphohistiocytic (4/4), lichenoid infiltration (3/4), basal vacuolar degeneration (4/4), and dermal melanophages (4/4) were observed. The trunk was the major site of presentation (3/3) in IEMP patients. Brownish (2/3) and ashen-gray (1/3) was the coloring of lesions. Basal layer pigmentation (3/3) and dermal melanophages (3/3) were the most prominent findings. No basal vacuolar changes (0/3) were observed. Conclusion: Clinical and histopathological distinction between these conditions is challenging. We reevaluated our patients in this context. We predict that we have achieved more accurate terminology with the global consensus statement. Such a terminology might allow that these disorders may be compared with a collective terminology in the literature.","PeriodicalId":42454,"journal":{"name":"Turk Dermatoloji Dergisi-Turkish Journal of Dermatology","volume":"14 1","pages":"35 - 41"},"PeriodicalIF":0.1,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84046634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Cutaneous small-vessel vasculitis (CSVV) is a disease characterized histologically by leukocytoclastic vasculitis (LCV) and immune-complex deposition in small vessel walls. We aimed to evaluate the type of deposited immune complexes in patients with LCV and to determine the relationship between the immune-complex types and clinical and laboratory parameters. Materials and Methods: Patients who had been diagnosed as LCV histopathologically between 2000 and 2018 were retrospectively evaluated. Patients' medical records and pathology databases were reviewed to determine the demographic characteristics, clinical, laboratory, and histopathological findings. Direct immune fluorescence (DIF) findings to determine the immune-complex subtypes, including immunoglobulin A (IgA), immunoglobulin M (IgM), immunoglobulin G (IgG) or C3 deposition, were evaluated. Results: Sixty-eight patients were included in the study. A total of 36 (53%) patients had deposition in the perivascular or vessel walls, with at least one of IgA, IgM, IgG, or C3. IgA deposition was detected in 29 (42.6%) patients, IgM in 13 patients (19.1%), IgG in four patients (5.9%), and C3 in 31 patients (45.6%). Clinical features of the patients, including triggering factors, extracutaneous involvement, lesion localization, and skin findings, were compared with DIF findings. It was found no statistically significant difference between DIF-positive and DIF-negative groups (P > 0.05, for all). There was also no statistically significant difference in terms of laboratory findings between the groups (P > 0.05, for all). Conclusions: Our study showed that DIF findings did not play a role in determining the clinical findings, and they did not affect laboratory parameters in CSVV.
{"title":"The relationship between direct immunofluorescence findings and clinical and laboratory parameters in patients with cutaneous small vessel vasculitis","authors":"D. Gulseren, Ece Erbağcı, Ö. Gököz, N. Atakan","doi":"10.4103/tjd.tjd_13_20","DOIUrl":"https://doi.org/10.4103/tjd.tjd_13_20","url":null,"abstract":"Objective: Cutaneous small-vessel vasculitis (CSVV) is a disease characterized histologically by leukocytoclastic vasculitis (LCV) and immune-complex deposition in small vessel walls. We aimed to evaluate the type of deposited immune complexes in patients with LCV and to determine the relationship between the immune-complex types and clinical and laboratory parameters. Materials and Methods: Patients who had been diagnosed as LCV histopathologically between 2000 and 2018 were retrospectively evaluated. Patients' medical records and pathology databases were reviewed to determine the demographic characteristics, clinical, laboratory, and histopathological findings. Direct immune fluorescence (DIF) findings to determine the immune-complex subtypes, including immunoglobulin A (IgA), immunoglobulin M (IgM), immunoglobulin G (IgG) or C3 deposition, were evaluated. Results: Sixty-eight patients were included in the study. A total of 36 (53%) patients had deposition in the perivascular or vessel walls, with at least one of IgA, IgM, IgG, or C3. IgA deposition was detected in 29 (42.6%) patients, IgM in 13 patients (19.1%), IgG in four patients (5.9%), and C3 in 31 patients (45.6%). Clinical features of the patients, including triggering factors, extracutaneous involvement, lesion localization, and skin findings, were compared with DIF findings. It was found no statistically significant difference between DIF-positive and DIF-negative groups (P > 0.05, for all). There was also no statistically significant difference in terms of laboratory findings between the groups (P > 0.05, for all). Conclusions: Our study showed that DIF findings did not play a role in determining the clinical findings, and they did not affect laboratory parameters in CSVV.","PeriodicalId":42454,"journal":{"name":"Turk Dermatoloji Dergisi-Turkish Journal of Dermatology","volume":"226 1","pages":"42 - 47"},"PeriodicalIF":0.1,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86007322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Emiral, Ozkan Ozay, D. Arslantaş, A. Unsal, I. Bulur, H. Erdogan
Objective: The aim of this study was to determine the prevalence of acne rosacea among adults, examine some related variables and evaluate the quality of life. Methods: This cross-sectional study including 2226 individuals with an age of 18 years old-above who lived in Mahmudiye-Eskisehir, Turkey. The study group was visited in their houses individually and agreed to participate the study. The researchers completed the survey forms during face-to-face interviews, performed the examinations. The Short Form-36 scale was used to assess the quality of life. The Chi-square, Mann-Whitney U test, Logistic Regression Analysis were used in the statistical analyses. Results and Conclusions: Of the study group 910 (40.9%) were male. Their ages ranged from 18-95 years (Mean age: 47.2±16.7). The prevalence of acne rosacea was 22.6% (n = 504). Being over the age of 55, obesity, primary school or lower education, history of complaints related to the face, family history of acne rosacea and personal history of head and/or neck treatment were identified as important risk factors for acne rosacea. Participants with acne rosacea had low quality of life based on the physical function subscale. It may be useful to perform intermittent screening, directing suspect cases to a specialist physician for early diagnosis- treatment and raise awareness.
{"title":"Assessment of acne rosacea prevalence and quality of life between individuals aged 18 years and over in mahmudiye district center, Eskisehir, Turkey (A population-based study)","authors":"G. Emiral, Ozkan Ozay, D. Arslantaş, A. Unsal, I. Bulur, H. Erdogan","doi":"10.4103/tjd.tjd_14_20","DOIUrl":"https://doi.org/10.4103/tjd.tjd_14_20","url":null,"abstract":"Objective: The aim of this study was to determine the prevalence of acne rosacea among adults, examine some related variables and evaluate the quality of life. Methods: This cross-sectional study including 2226 individuals with an age of 18 years old-above who lived in Mahmudiye-Eskisehir, Turkey. The study group was visited in their houses individually and agreed to participate the study. The researchers completed the survey forms during face-to-face interviews, performed the examinations. The Short Form-36 scale was used to assess the quality of life. The Chi-square, Mann-Whitney U test, Logistic Regression Analysis were used in the statistical analyses. Results and Conclusions: Of the study group 910 (40.9%) were male. Their ages ranged from 18-95 years (Mean age: 47.2±16.7). The prevalence of acne rosacea was 22.6% (n = 504). Being over the age of 55, obesity, primary school or lower education, history of complaints related to the face, family history of acne rosacea and personal history of head and/or neck treatment were identified as important risk factors for acne rosacea. Participants with acne rosacea had low quality of life based on the physical function subscale. It may be useful to perform intermittent screening, directing suspect cases to a specialist physician for early diagnosis- treatment and raise awareness.","PeriodicalId":42454,"journal":{"name":"Turk Dermatoloji Dergisi-Turkish Journal of Dermatology","volume":"29 1","pages":"48 - 54"},"PeriodicalIF":0.1,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91160282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acrodermatitis enteropathica (AE) is a rare genetic autosomal recessive disorder, characterized by periorificial dermatitis, alopecia, and diarrhea due to zinc deficiency. We report a case of a 9-month-old baby boy with hair loss for 2 months, diarrhea for 1.5 months, skin peeling starting around mouth, nose, anus, gradually spreading all over body over 1 month, and fever for 10 days. Due to superadded bacterial infections and altered clinical picture, he was diagnosed as a case of staphylococcal scalded skin syndrome. With low serum zinc levels and improvement of skin lesions and diarrhea within 8 days of starting oral zinc therapy, it was confirmed to be a case of acrodermatitis enteropathica. It is important to consider AE as one of the differential diagnoses in pediatric chronic diarrhea cases with acral and/or periorificial skin lesions to prevent delay in the zinc supplementation treatment and mortality.
{"title":"A case of acrodermatitis enteropathica misdiagnosed as staphylococcal scalded skin syndrome","authors":"P. Bisht, A. Sood","doi":"10.4103/tjd.tjd_23_20","DOIUrl":"https://doi.org/10.4103/tjd.tjd_23_20","url":null,"abstract":"Acrodermatitis enteropathica (AE) is a rare genetic autosomal recessive disorder, characterized by periorificial dermatitis, alopecia, and diarrhea due to zinc deficiency. We report a case of a 9-month-old baby boy with hair loss for 2 months, diarrhea for 1.5 months, skin peeling starting around mouth, nose, anus, gradually spreading all over body over 1 month, and fever for 10 days. Due to superadded bacterial infections and altered clinical picture, he was diagnosed as a case of staphylococcal scalded skin syndrome. With low serum zinc levels and improvement of skin lesions and diarrhea within 8 days of starting oral zinc therapy, it was confirmed to be a case of acrodermatitis enteropathica. It is important to consider AE as one of the differential diagnoses in pediatric chronic diarrhea cases with acral and/or periorificial skin lesions to prevent delay in the zinc supplementation treatment and mortality.","PeriodicalId":42454,"journal":{"name":"Turk Dermatoloji Dergisi-Turkish Journal of Dermatology","volume":"44 1 1","pages":"57 - 60"},"PeriodicalIF":0.1,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88124682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Platelet-rich plasma (PRP) which is peripheral blood originated product contains high concentrated platelet and many growth factors. It has been used in dermatology for many indications, including alopecias and chronic nonhealing wounds. Pemphigus vulgaris (PV) is a chronic autoimmune bullous disease of the skin and mucous membranes. We report a case of PV induced after the treatment of PRP for female pattern hair loss. The first lesions of PV occurred on the application site of PRP in this case. The diagnosis of mucocutaneous PV was established according to the clinical, cytological, and serological findings. Many physical agents and drugs were reported to induce PV. As far as is known, there is no PRP-related PV case in the literature. An in vitro study demonstrated that PRP may trigger the acantholysis in a genetically susceptible patient and may lead to pemphigus. Virtually, there is no enough evidence showing PRP to cause pemphigus. However, PRP treatment should be performed carefully in such patients.
{"title":"A case of pemphigus vulgaris developing after platelet-rich plasma treatment","authors":"A. Eskiocak, C. Başsorgun, S. Uzun","doi":"10.4103/tjd.tjd_24_20","DOIUrl":"https://doi.org/10.4103/tjd.tjd_24_20","url":null,"abstract":"Platelet-rich plasma (PRP) which is peripheral blood originated product contains high concentrated platelet and many growth factors. It has been used in dermatology for many indications, including alopecias and chronic nonhealing wounds. Pemphigus vulgaris (PV) is a chronic autoimmune bullous disease of the skin and mucous membranes. We report a case of PV induced after the treatment of PRP for female pattern hair loss. The first lesions of PV occurred on the application site of PRP in this case. The diagnosis of mucocutaneous PV was established according to the clinical, cytological, and serological findings. Many physical agents and drugs were reported to induce PV. As far as is known, there is no PRP-related PV case in the literature. An in vitro study demonstrated that PRP may trigger the acantholysis in a genetically susceptible patient and may lead to pemphigus. Virtually, there is no enough evidence showing PRP to cause pemphigus. However, PRP treatment should be performed carefully in such patients.","PeriodicalId":42454,"journal":{"name":"Turk Dermatoloji Dergisi-Turkish Journal of Dermatology","volume":"22 1","pages":"55 - 56"},"PeriodicalIF":0.1,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75510828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Al-kuraishy, Nawar Hussian, Marwa Al-naimi, Ali I. Al-Gareeb
Vitiligo is a chronic acquired disease of pigmentation disorder. Melanocytes damage and hypopigmentation relate to the induction of oxidative and autoimmune disorders. Different previous studies illustrated the possible role of statins in the treatment of different types of vitiligo. Therefore, objective of this study was to elucidate the role of statins in the management of vitiligo. In general, an endeavor of this study article was to present a mini-review regarding the potential therapeutic effect of statins in the therapy of vitiligo. Results of the present study illustrated that statins inhibit the production of interferon gamma, expression of major histocompatibily complex, and T-cells activation in patients with active vitiligo. Statins have significant anti-inflammatory and immune-modulating activates in different modalities of vitiligo. Statins, have a potential effect against oxidative stress through the activation of anti-oxidant capacity and reduction of ROS in human melanocytes by upregulation of nuclear erythroid 2-related factor in the melanocytes. Statins improve melanogenesis in melanocytes though increasing tyrosinase mRNA production and augment the stimulatory effect of α-melanocyte-stimulating hormone from the pituitary gland on the melanocytes. Finally, statins therapy may produce significant inhibition of inflammatory reactions through the inhibition of chemokines. In conclusion, this study highlighted the potential role of statins in the treatment of vitiligo either systemic or localized through significant suppressions of oxidative stress, autoimmunity, and inflammatory reactions. Bidirectional effects of statins on oxidative and autoimmunity/inflammatory pathway making it as a novel therapy for vitiligo.
{"title":"Statins role in vitiligo: A mini-review","authors":"H. Al-kuraishy, Nawar Hussian, Marwa Al-naimi, Ali I. Al-Gareeb","doi":"10.4103/TJD.TJD_38_19","DOIUrl":"https://doi.org/10.4103/TJD.TJD_38_19","url":null,"abstract":"Vitiligo is a chronic acquired disease of pigmentation disorder. Melanocytes damage and hypopigmentation relate to the induction of oxidative and autoimmune disorders. Different previous studies illustrated the possible role of statins in the treatment of different types of vitiligo. Therefore, objective of this study was to elucidate the role of statins in the management of vitiligo. In general, an endeavor of this study article was to present a mini-review regarding the potential therapeutic effect of statins in the therapy of vitiligo. Results of the present study illustrated that statins inhibit the production of interferon gamma, expression of major histocompatibily complex, and T-cells activation in patients with active vitiligo. Statins have significant anti-inflammatory and immune-modulating activates in different modalities of vitiligo. Statins, have a potential effect against oxidative stress through the activation of anti-oxidant capacity and reduction of ROS in human melanocytes by upregulation of nuclear erythroid 2-related factor in the melanocytes. Statins improve melanogenesis in melanocytes though increasing tyrosinase mRNA production and augment the stimulatory effect of α-melanocyte-stimulating hormone from the pituitary gland on the melanocytes. Finally, statins therapy may produce significant inhibition of inflammatory reactions through the inhibition of chemokines. In conclusion, this study highlighted the potential role of statins in the treatment of vitiligo either systemic or localized through significant suppressions of oxidative stress, autoimmunity, and inflammatory reactions. Bidirectional effects of statins on oxidative and autoimmunity/inflammatory pathway making it as a novel therapy for vitiligo.","PeriodicalId":42454,"journal":{"name":"Turk Dermatoloji Dergisi-Turkish Journal of Dermatology","volume":"36 1","pages":"1 - 7"},"PeriodicalIF":0.1,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85085515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: Overexposure to the sun during childhood is a well-known risk factor for skin cancer. Childhood is a crucial period for establishing and continuing to develop healthy sun protection behaviors. The purpose of our study was to investigate parents' knowledge and compare their personal behaviors in regard to sun protection for themselves and for their children. Materials and Methods: We conducted a cross-sectional population-based study. A questionnaire was given to 738 parents, 700 of whom completed the questionnaire and were included in the study. Results: Among the 700 parents, 88% (n = 616) were female and 12% (n = 84) were male. The mean age of the parents and children was 35.1 ± 5.6 years and 5.2 ± 3.0 years, respectively. Eighty-three percent (n = 580) of the parents were aware of sun exposure during childhood as a risk factor for skin cancer, but approximately only 15% of the parents reported using sunscreen regularly for themselves and for their children. Fifty-two percent (n = 367) of the parents implied not using any protective clothing for their children. Conclusion: Our study showed that parents were aware of the risks of sun exposure and the need for sun protection for themselves and children, but protective practices were low overall. Parents should be included in educational interventions targeting sun protection behaviors toward themselves and their children.
{"title":"Parents' knowledge about sun exposure and a comparison of their personal practices versus those used to protect their children against the sun","authors":"E. Ozkur, Tugba Gür, S. Erdoğan, I. Altunay","doi":"10.4103/TJD.TJD_35_19","DOIUrl":"https://doi.org/10.4103/TJD.TJD_35_19","url":null,"abstract":"Objectives: Overexposure to the sun during childhood is a well-known risk factor for skin cancer. Childhood is a crucial period for establishing and continuing to develop healthy sun protection behaviors. The purpose of our study was to investigate parents' knowledge and compare their personal behaviors in regard to sun protection for themselves and for their children. Materials and Methods: We conducted a cross-sectional population-based study. A questionnaire was given to 738 parents, 700 of whom completed the questionnaire and were included in the study. Results: Among the 700 parents, 88% (n = 616) were female and 12% (n = 84) were male. The mean age of the parents and children was 35.1 ± 5.6 years and 5.2 ± 3.0 years, respectively. Eighty-three percent (n = 580) of the parents were aware of sun exposure during childhood as a risk factor for skin cancer, but approximately only 15% of the parents reported using sunscreen regularly for themselves and for their children. Fifty-two percent (n = 367) of the parents implied not using any protective clothing for their children. Conclusion: Our study showed that parents were aware of the risks of sun exposure and the need for sun protection for themselves and children, but protective practices were low overall. Parents should be included in educational interventions targeting sun protection behaviors toward themselves and their children.","PeriodicalId":42454,"journal":{"name":"Turk Dermatoloji Dergisi-Turkish Journal of Dermatology","volume":"19 1","pages":"8 - 13"},"PeriodicalIF":0.1,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89380117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gout, a disorder of purine metabolism, presents with acute or chronic arthritis and deposition of urate crystals in connective tissue and kidneys. Rarely, patients progress into chronic tophaceous gout (CTG). We emphasize on a 74-year-old male patient, who developed multiple gouty tophi over both his hands. In addition, both his feet were diffusely swollen. On detection of characteristic urate crystals from both his hands and feet lesions, the diagnosis of CTG was confirmed.
{"title":"Chronic tophaceous gout manifesting with bilateral diffuse pedal swelling: Cytology revisited with an update in its list of differentials","authors":"K. Mondal, Rupali Mandal","doi":"10.4103/TJD.TJD_39_19","DOIUrl":"https://doi.org/10.4103/TJD.TJD_39_19","url":null,"abstract":"Gout, a disorder of purine metabolism, presents with acute or chronic arthritis and deposition of urate crystals in connective tissue and kidneys. Rarely, patients progress into chronic tophaceous gout (CTG). We emphasize on a 74-year-old male patient, who developed multiple gouty tophi over both his hands. In addition, both his feet were diffusely swollen. On detection of characteristic urate crystals from both his hands and feet lesions, the diagnosis of CTG was confirmed.","PeriodicalId":42454,"journal":{"name":"Turk Dermatoloji Dergisi-Turkish Journal of Dermatology","volume":"16 1","pages":"23 - 24"},"PeriodicalIF":0.1,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91278732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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