O. Altun, Duygu Çelik Özen, N. Dedeoğlu, Ş. Duman, Gözde Eşer, Edanur Topaloğlu, Begüm Özemre, Kardelen Demirezer
Objective: The aim of this study was to evaluate periapical radiographs of enamel caries, dentin caries, and deep caries with exposed pulp and intact teeth obtained in vitro using photo-stimulated phosphor plates (PSP) under different exposure parameters. Methods: 3 non-carious extracted molars were selected. The obtained molars were embedded in the wax created from pink wax by ensuring approximal contact and a base was created. 14 different imaging protocols were used with 60 kVp, 4 mA 0.02-0.1 second and 70 kVp 7 mA, 0.25-1.25 second exposure parameters. Intact teeth were imaged with these various imaging protocols. Artificial cavities were then created for enamel caries, dentin caries and deep caries with exposed pulp and imaged according to the same protocols. The images were evaluated by 3 clinicians who were blind to the exposure protocol and caries status. Inter-observer agreement with actual situations was examined with Kappa statistics. Results: In the low-dose group, the kappa values of observer 1, observer 2, and observer 3 were 0.905, 0.952, 0.952, respectively. The kappa values of observer 1, observer 2, and observer 3 in the ultralow-dose group were 0.833, 1, 1, and the kappa values of observer 1, observer 2, and observer 3 in the high-dose group were 1, 1, 0.833, respectively. The results obtained in all groups showed a statistically significant-excellent agreement (p<0.001). Conclusion: Approximal caries can be diagnosed with intraoral radiography obtained with low radiation doses with PSP in dentistry. Thus, patients could be exposed to less ionizing radiation.
{"title":"In-vitro Diagnosis of Approximal Caries in Teeth Periapical Radiography with Different Exposure Parameters","authors":"O. Altun, Duygu Çelik Özen, N. Dedeoğlu, Ş. Duman, Gözde Eşer, Edanur Topaloğlu, Begüm Özemre, Kardelen Demirezer","doi":"10.58600/eurjther1900","DOIUrl":"https://doi.org/10.58600/eurjther1900","url":null,"abstract":"Objective: The aim of this study was to evaluate periapical radiographs of enamel caries, dentin caries, and deep caries with exposed pulp and intact teeth obtained in vitro using photo-stimulated phosphor plates (PSP) under different exposure parameters.\u0000Methods: 3 non-carious extracted molars were selected. The obtained molars were embedded in the wax created from pink wax by ensuring approximal contact and a base was created. 14 different imaging protocols were used with 60 kVp, 4 mA 0.02-0.1 second and 70 kVp 7 mA, 0.25-1.25 second exposure parameters. Intact teeth were imaged with these various imaging protocols. Artificial cavities were then created for enamel caries, dentin caries and deep caries with exposed pulp and imaged according to the same protocols. The images were evaluated by 3 clinicians who were blind to the exposure protocol and caries status. Inter-observer agreement with actual situations was examined with Kappa statistics.\u0000Results: In the low-dose group, the kappa values of observer 1, observer 2, and observer 3 were 0.905, 0.952, 0.952, respectively. The kappa values of observer 1, observer 2, and observer 3 in the ultralow-dose group were 0.833, 1, 1, and the kappa values of observer 1, observer 2, and observer 3 in the high-dose group were 1, 1, 0.833, respectively. The results obtained in all groups showed a statistically significant-excellent agreement (p<0.001).\u0000Conclusion: Approximal caries can be diagnosed with intraoral radiography obtained with low radiation doses with PSP in dentistry. Thus, patients could be exposed to less ionizing radiation.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"79 9","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138596033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Latif Sağlam, Ö. Gayretli, O. Coşkun, İ. Gürses, B. Çandir, Aysi˙n Kale, Adnan Öztürk
Objective: The anatomy of the radial recurrent artery (RRA) is very important for interventional procedures. The aim of this study was to investigate the morphological and topographic anatomy of the RRA. Methods: The study was conducted on 20 human cadavers (14 male and 6 female, 40 upper limbs). The RRA was classified into 4 groups as follows according to the observed origin: RRA originated from the radial artery (RA) (Type A), the root of the RA (Type B), the brachial artery (BA) (Type C), and the ulnar artery (UA). The relative positioning of the RRA in relation to the biceps brachii muscle tendon (TBB), in terms of the antero-posterior direction was determined. The vertical distance of the origin point of the RRA to the intercondylar line and the diameters of this artery were determined. Morphometric evaluation was performed with a digital caliper. The obtained data were analyzed using SPSS version 21.00 software. Results: The artery most commonly originated from the RA (Type A 47.5%, 19 extremities). This was followed by RA root (Type B 32.5%, 13 extremities), BA (Type C 17.5%, 7 extremities), and UA (Type D 2.5%, 1 extremity). The RRAs coursed anteriorly to the TBB in 38 extremities (95%) and passed behind the tendon in 2 extremities (5%). The vertical distance of the origin point of the RRA to the intercondylar line was meanly 32.20 ±6.86 mm. The diameter of the artery at its origin point was meanly 2.57 ± 0.58 mm and just after its first branch was meanly 2.05 ± 0.48 mm. Our study documents a rare morphological variation of the RRA originating from the UA (Type D). Conclusion: While many of our findings align with previous studies, this research presents novel anatomical findings and elucidates the superficial course and topographical positioning of the RRA to estimate its origin point.
{"title":"Morphological and Topographical Features of the Radial Recurrent Artery and Its Possible Clinical Significance","authors":"Latif Sağlam, Ö. Gayretli, O. Coşkun, İ. Gürses, B. Çandir, Aysi˙n Kale, Adnan Öztürk","doi":"10.58600/eurjther1908","DOIUrl":"https://doi.org/10.58600/eurjther1908","url":null,"abstract":"Objective: The anatomy of the radial recurrent artery (RRA) is very important for interventional procedures. The aim of this study was to investigate the morphological and topographic anatomy of the RRA.\u0000Methods: The study was conducted on 20 human cadavers (14 male and 6 female, 40 upper limbs). The RRA was classified into 4 groups as follows according to the observed origin: RRA originated from the radial artery (RA) (Type A), the root of the RA (Type B), the brachial artery (BA) (Type C), and the ulnar artery (UA). The relative positioning of the RRA in relation to the biceps brachii muscle tendon (TBB), in terms of the antero-posterior direction was determined. The vertical distance of the origin point of the RRA to the intercondylar line and the diameters of this artery were determined. Morphometric evaluation was performed with a digital caliper. The obtained data were analyzed using SPSS version 21.00 software.\u0000Results: The artery most commonly originated from the RA (Type A 47.5%, 19 extremities). This was followed by RA root (Type B 32.5%, 13 extremities), BA (Type C 17.5%, 7 extremities), and UA (Type D 2.5%, 1 extremity). The RRAs coursed anteriorly to the TBB in 38 extremities (95%) and passed behind the tendon in 2 extremities (5%). The vertical distance of the origin point of the RRA to the intercondylar line was meanly 32.20 ±6.86 mm. The diameter of the artery at its origin point was meanly 2.57 ± 0.58 mm and just after its first branch was meanly 2.05 ± 0.48 mm. Our study documents a rare morphological variation of the RRA originating from the UA (Type D).\u0000Conclusion: While many of our findings align with previous studies, this research presents novel anatomical findings and elucidates the superficial course and topographical positioning of the RRA to estimate its origin point.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"41 11","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138596568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Heart failure (HF) is a significant public health issue in Turkey. The goal of this study was to look into how red cell distribution width (RDW) affected patients with acute decompensated HF (ADHF) patients' prognoses. Methods: A total of 101 ADHF patients under the age of 18 were enrolled in the study. Venous blood was drawn to measure the serum rdw. After a year of follow-up, the patients' survival status was determined. Results: The patients' mean age was 72. Forty-nine patients had heart failure (HF) with a reduced ejection fraction (EF), 8 had HF with a mildly reduced EF, and 44 had HF with a preserved EF. The median RDW value was 15.9%. In the hospital, nine patients passed away, and 92 others were discharged. 14 patients were lost to follow-up after one year, 87 patients completed the trial, and 40 patients passed away. Inotropic medication use, and serum RDW value were identified as independent predictors of 1-year death in ADHF patients by multivariate logistic regression analysis. According to this data, there was a 44% increase in 1-year mortality for every 1% increase in RDW. Conclusion: In Turkish patients hospitalized for ADHF, red cell distribution width represents an independent prognostic predictor for 1-year mortality.
{"title":"Red Cell Distribution Width Is an Independent Predictor of 1-Year Mortality in a Turkish Patient Population with Acute Decompensated Heart Failure","authors":"Umit Yuksek","doi":"10.58600/eurjther1803","DOIUrl":"https://doi.org/10.58600/eurjther1803","url":null,"abstract":"Objective: Heart failure (HF) is a significant public health issue in Turkey. The goal of this study was to look into how red cell distribution width (RDW) affected patients with acute decompensated HF (ADHF) patients' prognoses. Methods: A total of 101 ADHF patients under the age of 18 were enrolled in the study. Venous blood was drawn to measure the serum rdw. After a year of follow-up, the patients' survival status was determined. Results: The patients' mean age was 72. Forty-nine patients had heart failure (HF) with a reduced ejection fraction (EF), 8 had HF with a mildly reduced EF, and 44 had HF with a preserved EF. The median RDW value was 15.9%. In the hospital, nine patients passed away, and 92 others were discharged. 14 patients were lost to follow-up after one year, 87 patients completed the trial, and 40 patients passed away. Inotropic medication use, and serum RDW value were identified as independent predictors of 1-year death in ADHF patients by multivariate logistic regression analysis. According to this data, there was a 44% increase in 1-year mortality for every 1% increase in RDW. Conclusion: In Turkish patients hospitalized for ADHF, red cell distribution width represents an independent prognostic predictor for 1-year mortality.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"24 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139235044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
İçim Gökkaya, Tuğba Subaş, Gülin Renda, Sevim Şahin, U. Özgen, Nihal Yıldız, Ali Cansu
Objectives: The use of herbal products/dietary supplements (HP/DS) in the pediatric population is increasing day by day. The interaction of HP/DSs with drugs with a narrow therapeutic index such as phenytoin, phenobarbital, and valproic acid, may cause problems in treatment. In this respect, it is very important to determine the use of HP/DS in children with neurological diseases and/or complaints. In this study, it was aimed to determine the use of HP/DS and the factors affecting the use of these products in individuals with a neurological complaint and/or disease who applied to the pediatric neurology outpatient clinic. Methods: Parents were questioned face-to-face as part of the descriptive questionnaire research. 174 questionnaires with appropriate data quality were included in the study. The statistical software tool SPSS 23.0 was used to analyze the data. Results: 44.6% of the parents stated that they gave HP/DS to their children. The findings of the analysis showed that kids whose parents use HP/DS are more likely to utilize these items themselves (p<0.001). The most commonly used products are linden (70.1%), bee products (26.0%), carob (18.2%), chamomile (13.0%), and lemon (13.0%). It has been determined that the reasons for parents to have their children use HP/DS are to strengthen the immune system (51.9%), improve general health status (40.3%), and supplement normal nutrition (27.3%), respectively. Conclusions: This study revealed a high frequency of HP/DS use in children with pediatric neurological diseases/complaints in Türkiye. The frequency of HP/DS use was higher in children whose parents tended to consume HP/DS. Considering the high use of these products, healthcare professionals need to inform parents to prevent adverse effects caused by HP/DS.
{"title":"The Use of Herbal Products/Dietary Supplements and Affecting Factors in Patients Applying to a Pediatric Neurology Outpatient Clinic: A Descriptive Questionnaire Study","authors":"İçim Gökkaya, Tuğba Subaş, Gülin Renda, Sevim Şahin, U. Özgen, Nihal Yıldız, Ali Cansu","doi":"10.58600/eurjther1858","DOIUrl":"https://doi.org/10.58600/eurjther1858","url":null,"abstract":"Objectives: The use of herbal products/dietary supplements (HP/DS) in the pediatric population is increasing day by day. The interaction of HP/DSs with drugs with a narrow therapeutic index such as phenytoin, phenobarbital, and valproic acid, may cause problems in treatment. In this respect, it is very important to determine the use of HP/DS in children with neurological diseases and/or complaints. In this study, it was aimed to determine the use of HP/DS and the factors affecting the use of these products in individuals with a neurological complaint and/or disease who applied to the pediatric neurology outpatient clinic. Methods: Parents were questioned face-to-face as part of the descriptive questionnaire research. 174 questionnaires with appropriate data quality were included in the study. The statistical software tool SPSS 23.0 was used to analyze the data. Results: 44.6% of the parents stated that they gave HP/DS to their children. The findings of the analysis showed that kids whose parents use HP/DS are more likely to utilize these items themselves (p<0.001). The most commonly used products are linden (70.1%), bee products (26.0%), carob (18.2%), chamomile (13.0%), and lemon (13.0%). It has been determined that the reasons for parents to have their children use HP/DS are to strengthen the immune system (51.9%), improve general health status (40.3%), and supplement normal nutrition (27.3%), respectively. Conclusions: This study revealed a high frequency of HP/DS use in children with pediatric neurological diseases/complaints in Türkiye. The frequency of HP/DS use was higher in children whose parents tended to consume HP/DS. Considering the high use of these products, healthcare professionals need to inform parents to prevent adverse effects caused by HP/DS.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"7 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139259402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Birsen, Osman Sinen, Simla Su Akkan, I. Üstünel, V. İzgüt-Uysal, Prof. Dr. V. Nimet, Simla Su, PhD Akkan
Objective: The apelinergic system, consisting of apelin, ELABELA, and the apelin receptor (APJ), has a wide range of roles in physiological and pathophysiological processes in tissues. The effects of increased apelin and APJ as an indicator of damage in inflammatory conditions or as a compensatory mechanism are not fully clear in inflammatory bowel disease (IBD). This study was designed to assess the role of APJ in 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis model. Methods: Colitis in adult male Wistar rats were induced by intrarectally administered TNBS (30 mg b.w. in 50% ethanol). While the control group was treated with only saline to the colon, the TNBS+F13A and F13A groups received the APJ antagonist F13A (30 µg/kg/day, i.v.) for 3 days, starting immediately after TNBS or saline administration, respectively. Results: A decrease in body weight and an increase in colon weight/length ratio and stool consistency score were observed in the TNBS group. TNBS caused an increase in the myeloperoxidase (MPO) activity and the number of proinflammatory cytokines (TNF-α, IL-1β, and IL-6), as well as apelin production, leading to mucosal ulceration, necrosis, and submucosal edema in the colon. While F13A administration to the control did not cause any change in the colon, F13A administration immediately after TNBS greatly reduced the effects of TNBS. Conclusion: APJ is involved in the development of damage in colitis induced by TNBS. F13A reduces the level of damage, inflammatory cell infiltration, and MPO enzyme activity. APJ may be a therapeutic target in IBD.
{"title":"Blocking the Apelin Receptor (APJ) Attenuates TNBS-Induced Colitis in Rats","authors":"I. Birsen, Osman Sinen, Simla Su Akkan, I. Üstünel, V. İzgüt-Uysal, Prof. Dr. V. Nimet, Simla Su, PhD Akkan","doi":"10.58600/eurjther1883","DOIUrl":"https://doi.org/10.58600/eurjther1883","url":null,"abstract":"Objective: The apelinergic system, consisting of apelin, ELABELA, and the apelin receptor (APJ), has a wide range of roles in physiological and pathophysiological processes in tissues. The effects of increased apelin and APJ as an indicator of damage in inflammatory conditions or as a compensatory mechanism are not fully clear in inflammatory bowel disease (IBD). This study was designed to assess the role of APJ in 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis model. Methods: Colitis in adult male Wistar rats were induced by intrarectally administered TNBS (30 mg b.w. in 50% ethanol). While the control group was treated with only saline to the colon, the TNBS+F13A and F13A groups received the APJ antagonist F13A (30 µg/kg/day, i.v.) for 3 days, starting immediately after TNBS or saline administration, respectively. Results: A decrease in body weight and an increase in colon weight/length ratio and stool consistency score were observed in the TNBS group. TNBS caused an increase in the myeloperoxidase (MPO) activity and the number of proinflammatory cytokines (TNF-α, IL-1β, and IL-6), as well as apelin production, leading to mucosal ulceration, necrosis, and submucosal edema in the colon. While F13A administration to the control did not cause any change in the colon, F13A administration immediately after TNBS greatly reduced the effects of TNBS. Conclusion: APJ is involved in the development of damage in colitis induced by TNBS. F13A reduces the level of damage, inflammatory cell infiltration, and MPO enzyme activity. APJ may be a therapeutic target in IBD.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"55 2","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139256278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gülsüm Derya Aktaş, Nadire Ünver Doğan, Gülperi Çelik, Mustafa Koplay, Z. Fazlıoğulları, İbrahim Altındaş, A. Karabulut
Objective: The purpose of this study was to evaluate renal arteries and aorta anatomy in patients with chronic kidney disease (CKD) and compare them with a control group. Methods: Computed tomography images of 800 individuals (551 of that were with CKD and 249 of them were completely healthy in terms of urinary system) were evaluated retrospectively. Age range of the individuals 19 - 91 years (mean 61.15 ± 12.58). The differences between the renal arteries diameters, diameters of aorta, courses of the renal arteries, their separation levels from the aorta was investigated between the control group and patients with CKD. Results: Diameters of aorta and renal arteries are statistically significantly larger in CKD patients than healthy individuals and there was a negative correlation between the diameters of aorta with glomerular filtration rate. No statistically significant difference was observed between CKD patients and healthy individuals in terms of renal artery course. No statistically significant difference was detected between CKD patients and healthy individuals in terms of the branching level of the renal arteries from the aorta. Conclusion: Our study is one of the first studies which these measurements were made in individuals with CKD, according to the available literature. This study is important in that it reveals that the diameters of the renal arteries and aorta is statistically significantly larger in patients with CKD than in healthy individuals. These data may be important for the surgeons in interventional applications.
{"title":"Review of the Renal Artery Anatomy: In Chronic Kidney Disease and Healthy Individuals","authors":"Gülsüm Derya Aktaş, Nadire Ünver Doğan, Gülperi Çelik, Mustafa Koplay, Z. Fazlıoğulları, İbrahim Altındaş, A. Karabulut","doi":"10.58600/eurjther1854","DOIUrl":"https://doi.org/10.58600/eurjther1854","url":null,"abstract":"Objective: The purpose of this study was to evaluate renal arteries and aorta anatomy in patients with chronic kidney disease (CKD) and compare them with a control group. Methods: Computed tomography images of 800 individuals (551 of that were with CKD and 249 of them were completely healthy in terms of urinary system) were evaluated retrospectively. Age range of the individuals 19 - 91 years (mean 61.15 ± 12.58). The differences between the renal arteries diameters, diameters of aorta, courses of the renal arteries, their separation levels from the aorta was investigated between the control group and patients with CKD. Results: Diameters of aorta and renal arteries are statistically significantly larger in CKD patients than healthy individuals and there was a negative correlation between the diameters of aorta with glomerular filtration rate. No statistically significant difference was observed between CKD patients and healthy individuals in terms of renal artery course. No statistically significant difference was detected between CKD patients and healthy individuals in terms of the branching level of the renal arteries from the aorta. Conclusion: Our study is one of the first studies which these measurements were made in individuals with CKD, according to the available literature. This study is important in that it reveals that the diameters of the renal arteries and aorta is statistically significantly larger in patients with CKD than in healthy individuals. These data may be important for the surgeons in interventional applications.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"10 3","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139259000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ulaş Karabay, Latif Yılmaz, Alper Aytekin, Aziz Bulut
Objective: The prognostic factors that are important for colorectal cancer are the pathological grade of the tumor and the existence of lymph node involvement. Currently, the curative treatment option is resection of the tumor with adequate length and margin along with complete dissection of lymph nodes draining the site of resection. Our study investigated into retrieving adequate lymph nodes for accurate staging as well as the relationship between lymph nodes and colon and rectum specimen length. Methods: This retrospective cross-sectional study examined the correlation between resected colon length and lymph node count in people with colorectal cancer diagnosed between January 2010 and June 2018. We defined a cutoff value for the segment length to be resected to allow adequate staging of the tumor. Furthermore, we examined the relationship between the resected segment lengths and survival. Results: Of the patients who were included in this study, 211 were men and 169 were women. The mean resected colon length was 26.47±17.09 cm and the mean dissected lymph node count was 29.05±20.84. There was a positive correlation between specimen length and total lymph node count as well as specimen length and the existence of reactive lymph nodes that were statistically significant (r=0.319, p=0.001; r=0.312, p=0.001, respectively). In our study, tumor localization was described in three regions: the right colon, left colon and rectum. The mean right colon region specimen length was 28.8±15.5 cm, while it was 22.0±11.0 cm for the left colon region, and 21.7±10.6 cm for the rectum region. The 5-year overall survival rate was 53.2%, whereas the 5-year disease-specific survival rate was 58.2%. Conclusion: The mean specimen length to achieve the cutoff value for adequate lymph node retrieval (least 12 lymph nodes) was 16 cm in our study (ROC curve, AUC=0.689±0.05, p=0.001). The resected colon length and the number of retrieved lymph nodes were positively correlated in our study. Based on this confirmation, a cutoff value of 16 cm was calculated to achieve an adequate segment length to be resected.
{"title":"The Relationship Between the Resected Colon Length and the Number of Lymph Nodes in Colorectal Cancer: A Retrospective Cohort Study","authors":"Ulaş Karabay, Latif Yılmaz, Alper Aytekin, Aziz Bulut","doi":"10.58600/eurjther1862","DOIUrl":"https://doi.org/10.58600/eurjther1862","url":null,"abstract":"Objective: The prognostic factors that are important for colorectal cancer are the pathological grade of the tumor and the existence of lymph node involvement. Currently, the curative treatment option is resection of the tumor with adequate length and margin along with complete dissection of lymph nodes draining the site of resection. Our study investigated into retrieving adequate lymph nodes for accurate staging as well as the relationship between lymph nodes and colon and rectum specimen length. Methods: This retrospective cross-sectional study examined the correlation between resected colon length and lymph node count in people with colorectal cancer diagnosed between January 2010 and June 2018. We defined a cutoff value for the segment length to be resected to allow adequate staging of the tumor. Furthermore, we examined the relationship between the resected segment lengths and survival. Results: Of the patients who were included in this study, 211 were men and 169 were women. The mean resected colon length was 26.47±17.09 cm and the mean dissected lymph node count was 29.05±20.84. There was a positive correlation between specimen length and total lymph node count as well as specimen length and the existence of reactive lymph nodes that were statistically significant (r=0.319, p=0.001; r=0.312, p=0.001, respectively). In our study, tumor localization was described in three regions: the right colon, left colon and rectum. The mean right colon region specimen length was 28.8±15.5 cm, while it was 22.0±11.0 cm for the left colon region, and 21.7±10.6 cm for the rectum region. The 5-year overall survival rate was 53.2%, whereas the 5-year disease-specific survival rate was 58.2%. Conclusion: The mean specimen length to achieve the cutoff value for adequate lymph node retrieval (least 12 lymph nodes) was 16 cm in our study (ROC curve, AUC=0.689±0.05, p=0.001). The resected colon length and the number of retrieved lymph nodes were positively correlated in our study. Based on this confirmation, a cutoff value of 16 cm was calculated to achieve an adequate segment length to be resected.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139256808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: This study aimed to investigate the effects of difficulties experienced in the follow-up and treatment during the Coronavirus 2019 pandemic (COVID-19p), which included COVID-19 phobia and depression, on treatment compliance in patients with Chronic Obstructive Pulmonary Disease (COPD). Methods: This study included 123 patients with COPD. The COVID-19 Phobia Scale (C19P-S), Beck Depression Inventory (BDI), and Medication Adherence Report Scale (MARS) were used to assess the patients. Results: The mean age of patients with COPD was 64.56 ± 9.31 years. It was determined that our patients did not maintain regular outpatient follow-up mostly because of the fear of COVID-19 transmission (75.9%). Overall, 24% of our patients showed treatment noncompliance. A statistically significant relationship was found between COPD stages B and D and treatment compliance (p=0.01). Patients with frequent emergency department admissions (p = 0.01) and those with high BDI (p = 0.01) and C19P-S (p = 0.02) scores during the pandemic were found to have reduced treatment compliance. Conclusion: Patients with COPD with COVID-19 phobia, and depression had reduced treatment compliance. İt is necessary to be aware of these conditions and to plan appropriate interventions.
{"title":"Factors Affecting Treatment Compliance of Patients With COPD During the COVID-19 Pandemic","authors":"Sibel Doğru, Füsun Fakılı, Sema Aytaç, Cengizhan Sezgi, Mahşuk Taylan, Nazan Gülhan Bayram, Meral Uyar","doi":"10.58600/eurjther1752","DOIUrl":"https://doi.org/10.58600/eurjther1752","url":null,"abstract":"Objective: This study aimed to investigate the effects of difficulties experienced in the follow-up and treatment during the Coronavirus 2019 pandemic (COVID-19p), which included COVID-19 phobia and depression, on treatment compliance in patients with Chronic Obstructive Pulmonary Disease (COPD). Methods: This study included 123 patients with COPD. The COVID-19 Phobia Scale (C19P-S), Beck Depression Inventory (BDI), and Medication Adherence Report Scale (MARS) were used to assess the patients. Results: The mean age of patients with COPD was 64.56 ± 9.31 years. It was determined that our patients did not maintain regular outpatient follow-up mostly because of the fear of COVID-19 transmission (75.9%). Overall, 24% of our patients showed treatment noncompliance. A statistically significant relationship was found between COPD stages B and D and treatment compliance (p=0.01). Patients with frequent emergency department admissions (p = 0.01) and those with high BDI (p = 0.01) and C19P-S (p = 0.02) scores during the pandemic were found to have reduced treatment compliance. Conclusion: Patients with COPD with COVID-19 phobia, and depression had reduced treatment compliance. İt is necessary to be aware of these conditions and to plan appropriate interventions.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"51 32","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135432976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Thiazide diuretics are among the major anti-hypertensive medications. However, their hyperuricemic effect restricts their use in patients with gout. Sodium glucose co-transporter 2 inhibitor (SGLT-2i) initiation lowers serum uric acid (SUA) levels. It is not known whether existing SGLT-2i use affects the SUA increasing effect of thiazides. Methods: Post-hoc data analysis of our published study was conducted. Hypertensive patients who were initiated on thiazide diuretics or whose dose escalated were included (thiazide exposure). Demographic, clinical, and laboratory data were acquired via an electronic database. Patients were grouped according to SGLT-2i presence at the time of thiazide exposure. Since the number of SGLT-2i users was low, bootstrapping via simple random sampling was performed. Results: 144 patients were included in the study, of whom 13 were on SGLT-2i. Initial sample analysis revealed that while baseline SUA levels were similar between groups, SUA change was significantly lower after thiazide exposure among patients receiving SGLT-2i (0.6 vs. 0.2, p = 0.039). Similarly, baseline SUA levels were similar, but SUA change after thiazide exposure was significantly lower among patients receiving SGLT-2 on bootstrapped data (0.13 [-0.25 - 0.57, 95%CI], vs. 0.61 [0.45 - 0.78, 95%CI], mean difference = 0.48, [0.04 - 0.91, 95%CI], p = 0.029). Conclusion: This study revealed that thiazide diuretics may be a safe anti-hypertensive medication in terms of hyperuricemia among patients using SGLT-2i. Further studies with similar outcomes may result in the elimination of restrictive recommendations for the use of thiazides in patients with hyperuricemia or gout, provided patients are on SGLT-2i.
目的:噻嗪类利尿剂是主要的降压药物之一。然而，它们的高尿酸血症作用限制了它们在痛风患者中的应用。葡萄糖共转运蛋白2抑制剂钠(SGLT-2i)起始降低血清尿酸(SUA)水平。目前尚不清楚SGLT-2i的使用是否会影响噻嗪类药物增加SUA的效果。方法:对我们发表的研究进行事后数据分析。开始使用噻嗪类利尿剂或剂量增加的高血压患者被纳入(噻嗪类暴露)。通过电子数据库获取人口统计、临床和实验室数据。患者根据噻嗪暴露时SGLT-2i的存在进行分组。由于SGLT-2i用户数量较少，通过简单的随机抽样进行引导。结果:144例患者纳入研究，其中13例接受SGLT-2i治疗。初步样本分析显示，虽然两组之间的基线SUA水平相似，但在接受SGLT-2i的患者中，噻嗪暴露后SUA变化显著降低(0.6 vs. 0.2, p = 0.039)。同样，基线SUA水平相似，但在启动数据中接受SGLT-2治疗的患者中，噻嗪暴露后SUA变化显著降低(0.13 [-0.25 - 0.57,95%CI] vs. 0.61 [0.45 - 0.78, 95%CI]，平均差异= 0.48，[0.04 - 0.91,95%CI]， p = 0.029)。结论:本研究表明噻嗪类利尿剂对于SGLT-2i患者的高尿酸血症可能是一种安全的降压药物。类似结果的进一步研究可能导致取消对高尿酸血症或痛风患者使用噻嗪类药物的限制性建议，前提是患者服用SGLT-2i。
{"title":"Baseline Sodium-Glucose Cotransporter-2 Inhibitor Use Strongly Attenuates the Uric Acid-Elevating Effect of Thiazide Exposure","authors":"Alper Tuna Güven, Murat Özdede, Yusuf Ziya Şener","doi":"10.58600/eurjther1889","DOIUrl":"https://doi.org/10.58600/eurjther1889","url":null,"abstract":"Objective: Thiazide diuretics are among the major anti-hypertensive medications. However, their hyperuricemic effect restricts their use in patients with gout. Sodium glucose co-transporter 2 inhibitor (SGLT-2i) initiation lowers serum uric acid (SUA) levels. It is not known whether existing SGLT-2i use affects the SUA increasing effect of thiazides. Methods: Post-hoc data analysis of our published study was conducted. Hypertensive patients who were initiated on thiazide diuretics or whose dose escalated were included (thiazide exposure). Demographic, clinical, and laboratory data were acquired via an electronic database. Patients were grouped according to SGLT-2i presence at the time of thiazide exposure. Since the number of SGLT-2i users was low, bootstrapping via simple random sampling was performed. Results: 144 patients were included in the study, of whom 13 were on SGLT-2i. Initial sample analysis revealed that while baseline SUA levels were similar between groups, SUA change was significantly lower after thiazide exposure among patients receiving SGLT-2i (0.6 vs. 0.2, p = 0.039). Similarly, baseline SUA levels were similar, but SUA change after thiazide exposure was significantly lower among patients receiving SGLT-2 on bootstrapped data (0.13 [-0.25 - 0.57, 95%CI], vs. 0.61 [0.45 - 0.78, 95%CI], mean difference = 0.48, [0.04 - 0.91, 95%CI], p = 0.029). Conclusion: This study revealed that thiazide diuretics may be a safe anti-hypertensive medication in terms of hyperuricemia among patients using SGLT-2i. Further studies with similar outcomes may result in the elimination of restrictive recommendations for the use of thiazides in patients with hyperuricemia or gout, provided patients are on SGLT-2i.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"51 29","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135432978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Portal vein thrombosis (PVT) is a common finding in liver cirrhosis. Besides low portal blood flow, thrombophilia, bacterial translocation and endotoxemia, platelets which are considered as important source of prothrombotic agents may play a role in thrombotic events in cirrhosis. Large platelets have been reported to have numerous granules that result in greater thrombotic and proinflammatory activity. We aimed to define the role of platelet indices in PVT among cirrhotic patients. Method: Cirrhotic patients admitted to Gastroenterology Clinic and having a dynamic radiological examination were assessed retrospectively. Demographic and laboratory findings were recorded including platelet distribution width (PDW) and mean platelet volume (MPV). Severity of cirrhosis was assessed with MELD (Model for End Stage Liver Disease) and Child-Pugh-Turcotte (CPT) scores Results: Study included 255 patients. Mean age was 60.6±10.2 years. 41.6% of patients were female. 50 (19.6%) patients had PVT. Patients with PVT did not differed from those without PVT in age, gender and presence of diabetes mellitus. Median platelet count was lower in patients with PVT (100 (22-370) vs 79,5 (22-573), p: 0,033). Mean MPV and PDW levels were similar between PVT and non-PVT groups (p >0.05). Although median MELD scores did not differ between groups, median CPT scores were significantly higher in PVT compared to non-PVT group (p:0,027). Conclusion: Cirrhotic patients with PVT had more prominent thrombocytopenia, but similar MPV and PDW levels compared to those without PVT.
目的:门静脉血栓形成(PVT)是肝硬化的常见表现。除了门静脉血流量低、血栓形成、细菌易位和内毒素血症外，血小板被认为是血栓形成因子的重要来源，可能在肝硬化血栓形成事件中发挥作用。据报道，大血小板有许多颗粒，导致更大的血栓和促炎活性。我们的目的是确定血小板指数在肝硬化患者PVT中的作用。方法:对在消化内科门诊就诊并行动态影像学检查的肝硬化患者进行回顾性评价。人口统计学和实验室结果记录包括血小板分布宽度(PDW)和平均血小板体积(MPV)。采用终末期肝病模型MELD (Model for End Stage Liver Disease)和Child-Pugh-Turcotte (CPT)评分评估肝硬化严重程度。平均年龄60.6±10.2岁。41.6%的患者为女性。50例(19.6%)患者有PVT, PVT患者与无PVT患者在年龄、性别和是否存在糖尿病方面没有差异。PVT患者中位血小板计数较低(100 (22-370)vs 79,5 (22-573)， p: 0,033)。PVT组和非PVT组的平均MPV和PDW水平相似(p >0.05)。虽然MELD中位数评分在两组之间没有差异，但PVT组的中位数CPT评分明显高于非PVT组(p: 0.027)。结论:肝硬化伴PVT患者血小板减少更明显，但MPV和PDW水平与无PVT患者相似。
{"title":"Predictive Effects of Platelet Indices in Cirrhotic Patients with or without Portal Vein Thrombosis","authors":"Filiz Araz, Barış Soydaş","doi":"10.58600/eurjther1832","DOIUrl":"https://doi.org/10.58600/eurjther1832","url":null,"abstract":"Objective: Portal vein thrombosis (PVT) is a common finding in liver cirrhosis. Besides low portal blood flow, thrombophilia, bacterial translocation and endotoxemia, platelets which are considered as important source of prothrombotic agents may play a role in thrombotic events in cirrhosis. Large platelets have been reported to have numerous granules that result in greater thrombotic and proinflammatory activity. We aimed to define the role of platelet indices in PVT among cirrhotic patients. Method: Cirrhotic patients admitted to Gastroenterology Clinic and having a dynamic radiological examination were assessed retrospectively. Demographic and laboratory findings were recorded including platelet distribution width (PDW) and mean platelet volume (MPV). Severity of cirrhosis was assessed with MELD (Model for End Stage Liver Disease) and Child-Pugh-Turcotte (CPT) scores Results: Study included 255 patients. Mean age was 60.6±10.2 years. 41.6% of patients were female. 50 (19.6%) patients had PVT. Patients with PVT did not differed from those without PVT in age, gender and presence of diabetes mellitus. Median platelet count was lower in patients with PVT (100 (22-370) vs 79,5 (22-573), p: 0,033). Mean MPV and PDW levels were similar between PVT and non-PVT groups (p >0.05). Although median MELD scores did not differ between groups, median CPT scores were significantly higher in PVT compared to non-PVT group (p:0,027). Conclusion: Cirrhotic patients with PVT had more prominent thrombocytopenia, but similar MPV and PDW levels compared to those without PVT.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"40 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135475716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：