Özlem Kılıç, S. Çolak, Emre Tekgöz, A. Doğan, B. Öğüt, Aysu Sadioğlu, M. Çınar, Sedat Yılmaz
Dear Editor, Immunoglobulin G4-related disease (IgG4-RD) is an immune-mediated fibroinflammatory disease affecting multiple organ systems. The clinical findings may range due to the affected organ. The main distinguishing histopathological features of IgG4-RD are lymphoplasmacytic infiltration, storiform fibrosis, obliterative phlebitis, and mild or moderate tissue eosinophilia. Rarely, it may affect the lungs, hearts, pituitary, meninges, skin, prostate, breast, and thyroid gland [1–3]. In this article, we present a case diagnosed with IgG4-related disease involving multiple organs, including the pituitary, lymphatic system, kidney, and heart, and the patient responded well to immunosuppressive treatment. A fifty-five-year-old female patient applied with complaints of fatigue, polydipsia, polyuria, widespread body pain, and 20 kg weight loss in the last year. After excluding other possibilities, with a prediagnosis of diabetes insipidus (DI) pituitary MRI was performed which showed an increase in size and heterogeneous patchy contrast enhancement in the adenohypophysis (Fig. 1a). Based on the current clinical and imaging findings, the patient's laboratory results were evaluated, and central DI was diagnosed. In computerized thorax tomography, multiple lymph nodes in the mediastinum were detected, the largest of which was 21x17 mm. Tissue sampling was performed with the guidance of EBUS, pathological examination showed no diagnostic findings. Transesophageal Echocardiography (TEE) revealed an appearance consistent with a 10-15 mm thick thrombus surrounding the left atrium wall and narrowing the cavity. Increased thickness narrowing the left atrial lumen was reported in thorax computed tomography (CT) (Fig. 2). Further, a cardiac MRI was performed and reported to be consistent with lymphoproliferative-inflammatory involvement rather than thrombus. Abdominopelvic CT was performed and a lesion of 54x28 mm in size, less contrast enhancing than the surrounding parenchyma, in the middle part posterior of the left kidney was detected (Fig. 3). Histopathological findings were consistent with inflammatory processes, and no findings in favor of a neoplastic lymphoproliferative process were detected in the samples. Since the patient was presented with pituitary involvement, mediastinal lymphadenopathy, renal and cardiac mass, the IgG4 level was ordered and resulted as 299 mg/dl (3-201). IgG4 staining could not be performed in the current biopsy specimen; for confirming the diagnosis of IgG4-related disease, a re-biopsy was performed on the kidney mass. Histopathological findings were consistent with IGG4-RD (Fig. 4). Due to multisystemic involvement, the patient received 0.6 mg/kg/day oral corticosteroid and mycophenolate mofetil 3x1000 mg/day. The pituitary MRI that was performed in the first month of treatment was normal (Fig. 1b). Desmopressin treatment was stopped. Also, control TEE in the first-month follow-up visit showed a significant reduction in th
{"title":"Immunoglobulin-G4 Related Disease with Multiple Organ Involvement","authors":"Özlem Kılıç, S. Çolak, Emre Tekgöz, A. Doğan, B. Öğüt, Aysu Sadioğlu, M. Çınar, Sedat Yılmaz","doi":"10.58600/eurjther1960","DOIUrl":"https://doi.org/10.58600/eurjther1960","url":null,"abstract":"Dear Editor, Immunoglobulin G4-related disease (IgG4-RD) is an immune-mediated fibroinflammatory disease affecting multiple organ systems. The clinical findings may range due to the affected organ. The main distinguishing histopathological features of IgG4-RD are lymphoplasmacytic infiltration, storiform fibrosis, obliterative phlebitis, and mild or moderate tissue eosinophilia. Rarely, it may affect the lungs, hearts, pituitary, meninges, skin, prostate, breast, and thyroid gland [1–3]. In this article, we present a case diagnosed with IgG4-related disease involving multiple organs, including the pituitary, lymphatic system, kidney, and heart, and the patient responded well to immunosuppressive treatment. A fifty-five-year-old female patient applied with complaints of fatigue, polydipsia, polyuria, widespread body pain, and 20 kg weight loss in the last year. After excluding other possibilities, with a prediagnosis of diabetes insipidus (DI) pituitary MRI was performed which showed an increase in size and heterogeneous patchy contrast enhancement in the adenohypophysis (Fig. 1a). Based on the current clinical and imaging findings, the patient's laboratory results were evaluated, and central DI was diagnosed. In computerized thorax tomography, multiple lymph nodes in the mediastinum were detected, the largest of which was 21x17 mm. Tissue sampling was performed with the guidance of EBUS, pathological examination showed no diagnostic findings. Transesophageal Echocardiography (TEE) revealed an appearance consistent with a 10-15 mm thick thrombus surrounding the left atrium wall and narrowing the cavity. Increased thickness narrowing the left atrial lumen was reported in thorax computed tomography (CT) (Fig. 2). Further, a cardiac MRI was performed and reported to be consistent with lymphoproliferative-inflammatory involvement rather than thrombus. Abdominopelvic CT was performed and a lesion of 54x28 mm in size, less contrast enhancing than the surrounding parenchyma, in the middle part posterior of the left kidney was detected (Fig. 3). Histopathological findings were consistent with inflammatory processes, and no findings in favor of a neoplastic lymphoproliferative process were detected in the samples. Since the patient was presented with pituitary involvement, mediastinal lymphadenopathy, renal and cardiac mass, the IgG4 level was ordered and resulted as 299 mg/dl (3-201). IgG4 staining could not be performed in the current biopsy specimen; for confirming the diagnosis of IgG4-related disease, a re-biopsy was performed on the kidney mass. Histopathological findings were consistent with IGG4-RD (Fig. 4). Due to multisystemic involvement, the patient received 0.6 mg/kg/day oral corticosteroid and mycophenolate mofetil 3x1000 mg/day. The pituitary MRI that was performed in the first month of treatment was normal (Fig. 1b). Desmopressin treatment was stopped. Also, control TEE in the first-month follow-up visit showed a significant reduction in th","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"4 23","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139148733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ayşe Balat, Ş. Eren, M. Menzilcioğlu, İlhan Bahsi, İlkay Doğan, Davut Sinan Kaplan, M. Karadağ, A. Özçelik, Fatih Sarı, Hamit Yıldız
Dear Colleagues, In this editorial, we would like to share with you important developments in the European Journal of Therapeutics (Eur J Ther). First of all, as the editorial team, we would like you to know that we hold frequent meetings to benefit our esteemed colleagues and continue to work with great devotion in line with our goal of taking the journal further. We have previously shared with you that we have applied to many indexes. It is with great pleasure that we would like to inform you that in the last few months, more of our index applications have been approved. Index Copernicus, as a result of this application, the ICV 2022 value of our journal was determined to be 100 (approved 2023-10-31) [1] BASE (Bielefeld Academic Search Engine) (approved 2023-11-30) [2] Sherpa Romeo (approved 2023-09-27) [3] MIAR (approved 2023-10-16) [4] All indexes in our journal are currently included on the journal web page [5]. As the editorial team, we would like to inform you that we have determined a policy on this issue for our journal [6], taking into account the recommendations of important international ethics committees such as the Committee on Publication Ethics (COPE) [7] and the World Association of Medical Editors (WAME) [8], which have recently become a trendy topic of discussion about AI chatbots and academic studies prepared with the support of such tools. As you know, when our journal was founded in 1990 [9], it was published in two yearly issues. It is an essential responsibility for us to carry our journal, which continued its publication life with three issues a year in 2009 [10] and four issues a year in 2014 [11]. With your valuable support, we would like to announce that we will increase our journal to 6 issues a year as of 2024 (February, April, June, August, October and December) with the rapidly growing progress of our journal. Unfortunately, we cannot share the names of the referees who made significant contributions to our journal in 2023 due to the changes in the article submission interface during the year and the inaccessibility of some data in the previous interface. However, we would like to emphasize again that we are grateful to all of them for their valuable contributions. Moreover, to expand our journal's referee list, we would like to remind you that competent academics who volunteer in this regard can fill out the “Become a Reviewer for the European Journal of Therapeutics” form [12]. Finally, we would like to point out that we have strengthened our editorial team with an academician competent in dentistry, Fatih Sari, DDS, PhD. Fatih Sari, DDS, PhD, is a new Editorial Board Member of the Eur J Ther. Dr. Sari is an Associate Professor in the Department of Prosthodontics at the Gaziantep University Faculty of Dentistry. He is a Vice Dean of the Faculty of Dentistry and Head of Clinical Departments. Dr. Sari is a prosthodontist and a member of the Turkish Dental Association. He has experience in implant-supported fixed
{"title":"Welcome to the December 2023 Issue (Vol:29, No:4) and Current News of the European Journal of Therapeutics","authors":"Ayşe Balat, Ş. Eren, M. Menzilcioğlu, İlhan Bahsi, İlkay Doğan, Davut Sinan Kaplan, M. Karadağ, A. Özçelik, Fatih Sarı, Hamit Yıldız","doi":"10.58600/eurjther1968","DOIUrl":"https://doi.org/10.58600/eurjther1968","url":null,"abstract":"Dear Colleagues, In this editorial, we would like to share with you important developments in the European Journal of Therapeutics (Eur J Ther). First of all, as the editorial team, we would like you to know that we hold frequent meetings to benefit our esteemed colleagues and continue to work with great devotion in line with our goal of taking the journal further. We have previously shared with you that we have applied to many indexes. It is with great pleasure that we would like to inform you that in the last few months, more of our index applications have been approved. Index Copernicus, as a result of this application, the ICV 2022 value of our journal was determined to be 100 (approved 2023-10-31) [1] BASE (Bielefeld Academic Search Engine) (approved 2023-11-30) [2] Sherpa Romeo (approved 2023-09-27) [3] MIAR (approved 2023-10-16) [4] All indexes in our journal are currently included on the journal web page [5]. As the editorial team, we would like to inform you that we have determined a policy on this issue for our journal [6], taking into account the recommendations of important international ethics committees such as the Committee on Publication Ethics (COPE) [7] and the World Association of Medical Editors (WAME) [8], which have recently become a trendy topic of discussion about AI chatbots and academic studies prepared with the support of such tools. As you know, when our journal was founded in 1990 [9], it was published in two yearly issues. It is an essential responsibility for us to carry our journal, which continued its publication life with three issues a year in 2009 [10] and four issues a year in 2014 [11]. With your valuable support, we would like to announce that we will increase our journal to 6 issues a year as of 2024 (February, April, June, August, October and December) with the rapidly growing progress of our journal. Unfortunately, we cannot share the names of the referees who made significant contributions to our journal in 2023 due to the changes in the article submission interface during the year and the inaccessibility of some data in the previous interface. However, we would like to emphasize again that we are grateful to all of them for their valuable contributions. Moreover, to expand our journal's referee list, we would like to remind you that competent academics who volunteer in this regard can fill out the “Become a Reviewer for the European Journal of Therapeutics” form [12]. Finally, we would like to point out that we have strengthened our editorial team with an academician competent in dentistry, Fatih Sari, DDS, PhD. Fatih Sari, DDS, PhD, is a new Editorial Board Member of the Eur J Ther. Dr. Sari is an Associate Professor in the Department of Prosthodontics at the Gaziantep University Faculty of Dentistry. He is a Vice Dean of the Faculty of Dentistry and Head of Clinical Departments. Dr. Sari is a prosthodontist and a member of the Turkish Dental Association. He has experience in implant-supported fixed ","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"9 5","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139150817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Pekmez, E. Annaç, Özgür Bulmuş, Büşra Zencirci, Merve Aydın, Ali Aydın
Objective: Lead has been reported to cause oxidative stress in liver tissues and cause histopathological changes. Studies have shown that pomegranate juice has antioxidant properties that prevent oxidative stress. In this study, the harmful effects of lead acetate on rat liver tissue and the efficacy of pomegranate juice against these effects were investigated. Methods: 28 male Wistar albino rats were divided into four groups: control, lead acetate (50 mL/kg), pomegranate juice (1 mL/kg), and lead acetate + pomegranate juice (50 mL/kg+1 mL/kg). Lead acetate and pomegranate juice were administered orally. Results: When compared with the control group, it was seen that the lead acetate had an increase in the malondialdehyde level and a decrease in reduced Glutathione, Glutathione S-transferase, and Carboxylesterases. Group lead acetate + pomegranate juice had a reduction in malondialdehyde level and an increase in Glutathione, Glutathione S-transferase, and Carboxylesterases compared with the group lead acetate. The lead level of group lead acetate + pomegranate juice decreased compared to the group lead acetate. Cellular degeneration and irregular hepatic cords were observed in group lead acetate's liver tissue, and the negative changes were lost in group lead acetate + pomegranate juice. Conclusion: It was observed that pomegranate juice had a protective effect against liver toxicity caused by lead acetate.
{"title":"Protective Effect of Pomegranate Juice on Lead Acetate-Induced Liver Toxicity in Male Rats","authors":"H. Pekmez, E. Annaç, Özgür Bulmuş, Büşra Zencirci, Merve Aydın, Ali Aydın","doi":"10.58600/eurjther1927","DOIUrl":"https://doi.org/10.58600/eurjther1927","url":null,"abstract":"Objective: Lead has been reported to cause oxidative stress in liver tissues and cause histopathological changes. Studies have shown that pomegranate juice has antioxidant properties that prevent oxidative stress. In this study, the harmful effects of lead acetate on rat liver tissue and the efficacy of pomegranate juice against these effects were investigated. Methods: 28 male Wistar albino rats were divided into four groups: control, lead acetate (50 mL/kg), pomegranate juice (1 mL/kg), and lead acetate + pomegranate juice (50 mL/kg+1 mL/kg). Lead acetate and pomegranate juice were administered orally. Results: When compared with the control group, it was seen that the lead acetate had an increase in the malondialdehyde level and a decrease in reduced Glutathione, Glutathione S-transferase, and Carboxylesterases. Group lead acetate + pomegranate juice had a reduction in malondialdehyde level and an increase in Glutathione, Glutathione S-transferase, and Carboxylesterases compared with the group lead acetate. The lead level of group lead acetate + pomegranate juice decreased compared to the group lead acetate. Cellular degeneration and irregular hepatic cords were observed in group lead acetate's liver tissue, and the negative changes were lost in group lead acetate + pomegranate juice. Conclusion: It was observed that pomegranate juice had a protective effect against liver toxicity caused by lead acetate.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"37 2","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ali Türeyen, Fahriye Zemheri Navruz, Sevilay Günay, Yavuz Erden, S. Ince
Objective: Ovarian carcinoma is one of the most lethal gynecological cancers, as it responds later to diagnostic methods and therapeutic responses in advanced stages. Many phytochemical compounds have been shown to be protective against cancer. Tubuloside A (TbA) is the main compound extracted from the plant Cistanche tubulosa, and its pharmacological effects have been studied broadly. Until now, the role of TbA in human ovarian carcinoma is unknown. The goal of this study was to evaluate the effects of TbA on DNA damage and apoptosis in A2780 cell lines. Methods: Different concentrations of TbA (1, 5, 25, 50, and 100 µM) and 5- Fluorouracil (1, 5, 25, 50, and 100 µM) treated to the human ovarian cancer cell (A2780) line for 24 h. After incubation, cell viability (MTT), genotoxicity (Comet analyses), and mRNA expression analyses of apoptotic markers (Caspase-3, Bax, Bcl-2, and p53) were determined. Results: Applied doses of 50 and 100 µM of TbA and 5- Fluorouracil significantly reduced cell viability. Also, TbA increased DNA damage in A2780 cells. Additionally, TbA up-regulated the mRNA expressions of caspase-3, Bax, and p53, which are apoptosis-inducing factors, and down-regulated the expression of Bcl-2. Conclusion: These results show that the p53 and caspase-3 signaling pathways may exhibit a key role in TbA-associated effects on A2780 cells and TbA may be a potential drug aspirant for ovarian cancer therapy.
{"title":"Tubuloside A Induces DNA Damage and Apoptosis in Human Ovarian Cancer A2780 Cells","authors":"Ali Türeyen, Fahriye Zemheri Navruz, Sevilay Günay, Yavuz Erden, S. Ince","doi":"10.58600/eurjther1951","DOIUrl":"https://doi.org/10.58600/eurjther1951","url":null,"abstract":"Objective: Ovarian carcinoma is one of the most lethal gynecological cancers, as it responds later to diagnostic methods and therapeutic responses in advanced stages. Many phytochemical compounds have been shown to be protective against cancer. Tubuloside A (TbA) is the main compound extracted from the plant Cistanche tubulosa, and its pharmacological effects have been studied broadly. Until now, the role of TbA in human ovarian carcinoma is unknown. The goal of this study was to evaluate the effects of TbA on DNA damage and apoptosis in A2780 cell lines. Methods: Different concentrations of TbA (1, 5, 25, 50, and 100 µM) and 5- Fluorouracil (1, 5, 25, 50, and 100 µM) treated to the human ovarian cancer cell (A2780) line for 24 h. After incubation, cell viability (MTT), genotoxicity (Comet analyses), and mRNA expression analyses of apoptotic markers (Caspase-3, Bax, Bcl-2, and p53) were determined. Results: Applied doses of 50 and 100 µM of TbA and 5- Fluorouracil significantly reduced cell viability. Also, TbA increased DNA damage in A2780 cells. Additionally, TbA up-regulated the mRNA expressions of caspase-3, Bax, and p53, which are apoptosis-inducing factors, and down-regulated the expression of Bcl-2. Conclusion: These results show that the p53 and caspase-3 signaling pathways may exhibit a key role in TbA-associated effects on A2780 cells and TbA may be a potential drug aspirant for ovarian cancer therapy.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"49 5","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139155810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ş. Şahin, Y. Duymaz, Burak Erkmen, B. Karabulut, I. Deveci, Mehmet Sürmeli, Aslı Şahin Yılmaz, Aslıhan Semiz Oysu, Ç. Oysu
Correction to: Correlation of Diffusion-weighted MR imaging and FDG PET/CT in the Diagnosis of Metastatic Lymph Nodes of Head and Neck Malignant Tumors https://doi.org/10.58600/eurjther.20232902-450.y The original version of this article [1], unfortunately contained an error. The name of Aslıhan Semiz Oysu, who is one of the co-authors and took part in every stage of the study, was not inadvertently added to the author list by the corresponding author. The author apologizes for this confusion. Given in this article are the correct author names. Publisher's Note: The original article was corrected, and a correction note was added. Şahin Ş, Duymaz YK, Erkmen B, Karabulut B, Deveci İ, Sürmeli M, Şahin Yılmaz A, Semiz Oysu A, Oysu Ç (2023) Correlation of Diffusion-weighted MR imaging and FDG PET/CT in the Diagnosis of Metastatic Lymph Nodes of Head and Neck Malignant Tumors. Eur J Ther. 29(2):135-142. https://doi.org/10.58600/eurjther.20232902-450.y
{"title":"Correction to: Correlation of Diffusion-weighted MR imaging and FDG PET/CT in the Diagnosis of Metastatic Lymph Nodes of Head and Neck Malignant Tumors","authors":"Ş. Şahin, Y. Duymaz, Burak Erkmen, B. Karabulut, I. Deveci, Mehmet Sürmeli, Aslı Şahin Yılmaz, Aslıhan Semiz Oysu, Ç. Oysu","doi":"10.58600/eurjther1878","DOIUrl":"https://doi.org/10.58600/eurjther1878","url":null,"abstract":"Correction to: Correlation of Diffusion-weighted MR imaging and FDG PET/CT in the Diagnosis of Metastatic Lymph Nodes of Head and Neck Malignant Tumors https://doi.org/10.58600/eurjther.20232902-450.y The original version of this article [1], unfortunately contained an error. The name of Aslıhan Semiz Oysu, who is one of the co-authors and took part in every stage of the study, was not inadvertently added to the author list by the corresponding author. The author apologizes for this confusion. Given in this article are the correct author names. Publisher's Note: The original article was corrected, and a correction note was added. Şahin Ş, Duymaz YK, Erkmen B, Karabulut B, Deveci İ, Sürmeli M, Şahin Yılmaz A, Semiz Oysu A, Oysu Ç (2023) Correlation of Diffusion-weighted MR imaging and FDG PET/CT in the Diagnosis of Metastatic Lymph Nodes of Head and Neck Malignant Tumors. Eur J Ther. 29(2):135-142. https://doi.org/10.58600/eurjther.20232902-450.y","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"10 6","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139156755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dear Editor, As per World Health Organization (WHO) data, 5-15% of couples of reproductive age experience infertility. In vitro fertilization-embryo transfer (IVF-ET), which initially appeared at the end of the twenty-first century, is not only a core component of assisted reproductive technology but also an important way to treat infertile patients in modern medicine, giving the majority of infertile patients fertility hope [1]. Advanced maternal age (AMA) is a major clinical and social problem. At present, there is a significant increase in the percentage of women who delay pregnancy until their late third or early fourth decade of life [2]. Many elderly women prefer to use IVF to have children. However, it has been observed that the age of the female was one of the key determinants limiting fertility and reproductive results [3]. The International Council of Obstetricians and Gynaecologists introduced the term "elderly primigravida" in 1958 to describe women over the age of 35 who were embarking on their first pregnancy. Pre-eclampsia, gestational diabetes, foetal abnormalities, and premature birth have all been identified to carry an increased risk of maternal and foetal morbidity during the same time [4]. Women of advanced maternal age are frequently considered as if they need the level of care required for any high-risk pregnancy, and they are given special attention even when there is no scientific basis for it and no medical issues are evident. However, because of pre-existing and pregnancy-related morbidity, as well as high maternal expectations, these women require more intervention throughout pregnancy and delivery [5]. Advanced maternal age is linked to several financial, social, and physical problems for the mother as well as for the foetus [2]. Some studies discovered that elderly gravida were more likely to have a child with Down syndrome, as well as a higher chance of miscarriage and hypertension. However, the chances of requiring a Caesarean section, having a preterm or low-birth-weight baby, having a stillbirth, or having multiple births were not as well determined [5,6]. Intense physical change occurs during pregnancy, and many women experience significant emotional upheaval during this time. While improving the chances of favourable maternal and newborn outcomes during pregnancy remains the major objective of prenatal care, emphasis should also be given to how pregnancy-related conditions might influence a woman's life [7]. The loading and position of the vertebral column, as well as the muscular forces along it and in the weight-bearing joints, alter throughout pregnancy. Physiotherapy is vital in obstetrics, both during pregnancy and after delivery [8,9]. Hence, we present this letter to the editor of post-partum elderly gravida with IVF conception with gestational hypertension and gestational diabetes mellitus with cervical stitch in situ with its structured physiotherapy management. Patient Information: A 51-year-old woma
{"title":"Optimising Rehabilitation Strategies for Postpartum Elderly Gravida with In Vitro Fertilisation Conception","authors":"Purva Gulrandhe, Priyanka Telang, Simran Jaiswal","doi":"10.58600/eurjther1955","DOIUrl":"https://doi.org/10.58600/eurjther1955","url":null,"abstract":"Dear Editor, As per World Health Organization (WHO) data, 5-15% of couples of reproductive age experience infertility. In vitro fertilization-embryo transfer (IVF-ET), which initially appeared at the end of the twenty-first century, is not only a core component of assisted reproductive technology but also an important way to treat infertile patients in modern medicine, giving the majority of infertile patients fertility hope [1]. Advanced maternal age (AMA) is a major clinical and social problem. At present, there is a significant increase in the percentage of women who delay pregnancy until their late third or early fourth decade of life [2]. Many elderly women prefer to use IVF to have children. However, it has been observed that the age of the female was one of the key determinants limiting fertility and reproductive results [3]. The International Council of Obstetricians and Gynaecologists introduced the term \"elderly primigravida\" in 1958 to describe women over the age of 35 who were embarking on their first pregnancy. Pre-eclampsia, gestational diabetes, foetal abnormalities, and premature birth have all been identified to carry an increased risk of maternal and foetal morbidity during the same time [4]. Women of advanced maternal age are frequently considered as if they need the level of care required for any high-risk pregnancy, and they are given special attention even when there is no scientific basis for it and no medical issues are evident. However, because of pre-existing and pregnancy-related morbidity, as well as high maternal expectations, these women require more intervention throughout pregnancy and delivery [5]. Advanced maternal age is linked to several financial, social, and physical problems for the mother as well as for the foetus [2]. Some studies discovered that elderly gravida were more likely to have a child with Down syndrome, as well as a higher chance of miscarriage and hypertension. However, the chances of requiring a Caesarean section, having a preterm or low-birth-weight baby, having a stillbirth, or having multiple births were not as well determined [5,6]. Intense physical change occurs during pregnancy, and many women experience significant emotional upheaval during this time. While improving the chances of favourable maternal and newborn outcomes during pregnancy remains the major objective of prenatal care, emphasis should also be given to how pregnancy-related conditions might influence a woman's life [7]. The loading and position of the vertebral column, as well as the muscular forces along it and in the weight-bearing joints, alter throughout pregnancy. Physiotherapy is vital in obstetrics, both during pregnancy and after delivery [8,9]. Hence, we present this letter to the editor of post-partum elderly gravida with IVF conception with gestational hypertension and gestational diabetes mellitus with cervical stitch in situ with its structured physiotherapy management. Patient Information: A 51-year-old woma","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"27 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139159020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dear Editor, Advancements in invasive coronary angiography and accumulated experience have improved the success of interventions in challenging coronary artery lesions and associated complications. However, the approach and success in managing rare complications such as guide wire entrapment depend on the patient's hemodynamic status, continuity of coronary flow, capabilities of the angiography laboratory and the operator's expertise. In this letter, we present a case of guide wire entrapment during coronary intervention, the difficulties encountered during percutaneous removal attempts, and the finally applied conservative approach. Patient Information A 56-year-old male, known for active smoking and a history of three-vessel coronary bypass surgery four years ago, presented with pressing chest pain. The patient had undergone coronary angiography (CAG) a year ago, and medical follow-up was recommended. Due to the diagnosis of unstable angina pectoris, the patient underwent another angiography. Following the stent implantation for significant stenosis after the anastomosis in the saphenous-LAD graft, attempts to retrieve the guidewire resulted in stent deformation (Fig. 1) and entrapment. Despite efforts to retract the guidewire, it was unsuccessful. Subsequently, the case was urgently taken over, maintaining the catheter and guidewire in a sterile manner (Fig. 1). After obtaining cardiovascular surgical consultations, a decision was made to reattempt the procedure through percutaneous coronary intervention. After ensuring proper field cleanliness, the procedure began by confirming the absence of catheter thrombus. It was observed that there was no distal flow in the first images (Fig. 2). Attempts to enter the stent with a 1.0x12 mm Artimes balloon were unsuccessful, and after the balloon's deformation, a second attempt was made with another balloon but was also unsuccessful. Microcatheters were used to enter the stent, but they got trapped, and only after various manipulations, the microcatheter could be retracted. Subsequent attempts with PT-2 and Fielder XT-A Guidewires for the buddy wire technique were unsuccessful due to entrapment between stent struts (Fig. 1). Considering the thinness of the distal vessel and the chronic near 99% stenosis similar to previous CAG images, it was decided to attempt distal wire detachment due to the high surgical risk in this patient. However, despite attempts, the wire did not detach. During the wire retraction, the heart shadow on fluoroscopy moved, and the patient experienced severe pain. Since repeated pull-backs were unsuccessful, consecutive and prolonged torques were applied to the wire, resulting in distal wire fracture (Fig. 2). Echocardiographic control showed no effusion. The patient was transferred to the coronary intensive care unit. Following one day in the intensive care unit and two days in the cardiology service without symptoms, the patient was discharged with dual antiplatelet therapy. No a
{"title":"The Horrible Scenario in Cath Lab: Percutaneous Management of Guide Wire Entrapment During Coronary Intervention","authors":"Serhat Kesriklioğlu, A. Şahin, Yakup Alsancak","doi":"10.58600/eurjther1956","DOIUrl":"https://doi.org/10.58600/eurjther1956","url":null,"abstract":"Dear Editor, Advancements in invasive coronary angiography and accumulated experience have improved the success of interventions in challenging coronary artery lesions and associated complications. However, the approach and success in managing rare complications such as guide wire entrapment depend on the patient's hemodynamic status, continuity of coronary flow, capabilities of the angiography laboratory and the operator's expertise. In this letter, we present a case of guide wire entrapment during coronary intervention, the difficulties encountered during percutaneous removal attempts, and the finally applied conservative approach. Patient Information A 56-year-old male, known for active smoking and a history of three-vessel coronary bypass surgery four years ago, presented with pressing chest pain. The patient had undergone coronary angiography (CAG) a year ago, and medical follow-up was recommended. Due to the diagnosis of unstable angina pectoris, the patient underwent another angiography. Following the stent implantation for significant stenosis after the anastomosis in the saphenous-LAD graft, attempts to retrieve the guidewire resulted in stent deformation (Fig. 1) and entrapment. Despite efforts to retract the guidewire, it was unsuccessful. Subsequently, the case was urgently taken over, maintaining the catheter and guidewire in a sterile manner (Fig. 1). After obtaining cardiovascular surgical consultations, a decision was made to reattempt the procedure through percutaneous coronary intervention. After ensuring proper field cleanliness, the procedure began by confirming the absence of catheter thrombus. It was observed that there was no distal flow in the first images (Fig. 2). Attempts to enter the stent with a 1.0x12 mm Artimes balloon were unsuccessful, and after the balloon's deformation, a second attempt was made with another balloon but was also unsuccessful. Microcatheters were used to enter the stent, but they got trapped, and only after various manipulations, the microcatheter could be retracted. Subsequent attempts with PT-2 and Fielder XT-A Guidewires for the buddy wire technique were unsuccessful due to entrapment between stent struts (Fig. 1). Considering the thinness of the distal vessel and the chronic near 99% stenosis similar to previous CAG images, it was decided to attempt distal wire detachment due to the high surgical risk in this patient. However, despite attempts, the wire did not detach. During the wire retraction, the heart shadow on fluoroscopy moved, and the patient experienced severe pain. Since repeated pull-backs were unsuccessful, consecutive and prolonged torques were applied to the wire, resulting in distal wire fracture (Fig. 2). Echocardiographic control showed no effusion. The patient was transferred to the coronary intensive care unit. Following one day in the intensive care unit and two days in the cardiology service without symptoms, the patient was discharged with dual antiplatelet therapy. No a","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"33 30","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139166139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Acıduman, Abdullah Yıldız, Kemal Tuzcu, Hicabi Kırlangıç
Objective: The discovery of the pulmonary circulation is one of the most important issues in the history of medicine. Recently, an article appeared comprising an assertion that this discovery may have been made before Ibn al-Nafīs by Qusṭā b. Lūqā. The purpose of our study is to examine the text of Qusṭā b. Lūqā to ascertain whether it offers “new evidence” on the discovery of pulmonary circulation. Methods: A comprehensive analysis of the text Qusṭā b. Lūqā and its different copies referenced for the discovery made by Qusṭā b. Lūqā has been made regarding the history of medicine. Results: While Qusṭā b. Lūqā’s text contains detailed descriptions of cardiovascular anatomy, the terminologies and concepts employed were consistent with the prevailing medical knowledge of his time. From the perspective of the history of medicine, it can be said that Qusṭā b. Lūqā’s text does not sufficiently differentiate from those of his predecessors’ regarding the issue of pulmonary circulation. In addition, Qusṭā b. Lūqā mentions the sources he used in his text and does not explicitly claim that he made a discovery different from them. Conclusion: With the available findings, it is difficult for now to say that Qusṭā b. Lūqā discovered the pulmonary circulation in the referenced text.
目的：肺循环的发现是医学史上最重要的问题之一。最近有一篇文章断言，这一发现可能是 Qusṭā b. Lūqā 在 Ibn al-Nafīs 之前发现的。我们研究的目的是研究 Qusṭā b. Lūqā 的文本，以确定它是否为肺循环的发现提供了 "新证据"。研究方法全面分析了 Qusṭā b. Lūqā 一书及其不同副本中有关 Qusṭā b. Lūqā 发现的医学史参考文献。结果：虽然 Qusṭā b. Lūqā 的著作中包含对心血管解剖的详细描述，但其中使用的术语和概念与当时流行的医学知识是一致的。从医学史的角度来看，可以说 Qusṭā b. Lūqā 的文本在肺循环问题上与其前人的文本没有足够的区别。此外，Qusṭā b. Lūqā在其文本中提到了他所使用的资料来源，但并未明确声称他的发现与这些资料来源不同。结论：根据现有的研究结果，目前很难说 Qusṭā b. Lūqā 在参考文献中发现了肺循环。
{"title":"Is the Text of Ibn Lūqā “A New Evidence” on Pulmonary Circulation Discovery?","authors":"A. Acıduman, Abdullah Yıldız, Kemal Tuzcu, Hicabi Kırlangıç","doi":"10.58600/eurjther1913","DOIUrl":"https://doi.org/10.58600/eurjther1913","url":null,"abstract":"Objective: The discovery of the pulmonary circulation is one of the most important issues in the history of medicine. Recently, an article appeared comprising an assertion that this discovery may have been made before Ibn al-Nafīs by Qusṭā b. Lūqā. The purpose of our study is to examine the text of Qusṭā b. Lūqā to ascertain whether it offers “new evidence” on the discovery of pulmonary circulation. Methods: A comprehensive analysis of the text Qusṭā b. Lūqā and its different copies referenced for the discovery made by Qusṭā b. Lūqā has been made regarding the history of medicine. Results: While Qusṭā b. Lūqā’s text contains detailed descriptions of cardiovascular anatomy, the terminologies and concepts employed were consistent with the prevailing medical knowledge of his time. From the perspective of the history of medicine, it can be said that Qusṭā b. Lūqā’s text does not sufficiently differentiate from those of his predecessors’ regarding the issue of pulmonary circulation. In addition, Qusṭā b. Lūqā mentions the sources he used in his text and does not explicitly claim that he made a discovery different from them. Conclusion: With the available findings, it is difficult for now to say that Qusṭā b. Lūqā discovered the pulmonary circulation in the referenced text.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"153 ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139170857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: It has been hypothesized that a disproportionate upper body weight caused by macromastia places abnormal stress on the spine, which may lead to skeletal abnormalities. To evaluate whether there is a relationship between breast volume and the thoracic kyphosis angle measured on thorax CT images. Methods: A total of 448 female patients who underwent thoracic CT examinations were included in this study. Breast volume [ml], by using the "organ segmentation method"; thoracic kyphosis angles by using Cobb's method were made manually on the workstation. Results: Mean right breast volume was 902.03 ± 376.47 (154.21 - 2366.20 ml), left breast volume was 911.01 ± 383.34 (167.93 - 2894.07 ml), total breast volume was 1810.09 ± 750.82 (354.39 - 5100.68 ml). The total breast volume (p<0.001) and thoracic kyphosis angle (p=0.012)in patients aged 50-69 years were significantly higher than those aged 17-29 years. Larger total breast volume [p<0.001] and thoracic kyphosis angle (p<0.001) values were associated with larger BMI intervals. A significant positive correlation was observed between the total breast volume and thoracic kyphosis angle (r=0.771, p<0.001). Conclusion: Our results showed that the thoracic kyphosis angle significantly increased in parallel with a larger total breast volume, and that total breast volume was an independent risk factor for thoracic kyphosis angle. The manual organ segmentation method we used was found to be reliable and easy to apply, but time-consuming technique for calculating BV.
{"title":"The Relationship Between Breast Volume and Thoracic Kyphosis Angle","authors":"Şenay Bengin Ertem, Ü. A. Malçok","doi":"10.58600/eurjther1907","DOIUrl":"https://doi.org/10.58600/eurjther1907","url":null,"abstract":"Objective: It has been hypothesized that a disproportionate upper body weight caused by macromastia places abnormal stress on the spine, which may lead to skeletal abnormalities. To evaluate whether there is a relationship between breast volume and the thoracic kyphosis angle measured on thorax CT images. Methods: A total of 448 female patients who underwent thoracic CT examinations were included in this study. Breast volume [ml], by using the \"organ segmentation method\"; thoracic kyphosis angles by using Cobb's method were made manually on the workstation. Results: Mean right breast volume was 902.03 ± 376.47 (154.21 - 2366.20 ml), left breast volume was 911.01 ± 383.34 (167.93 - 2894.07 ml), total breast volume was 1810.09 ± 750.82 (354.39 - 5100.68 ml). The total breast volume (p<0.001) and thoracic kyphosis angle (p=0.012)in patients aged 50-69 years were significantly higher than those aged 17-29 years. Larger total breast volume [p<0.001] and thoracic kyphosis angle (p<0.001) values were associated with larger BMI intervals. A significant positive correlation was observed between the total breast volume and thoracic kyphosis angle (r=0.771, p<0.001). Conclusion: Our results showed that the thoracic kyphosis angle significantly increased in parallel with a larger total breast volume, and that total breast volume was an independent risk factor for thoracic kyphosis angle. The manual organ segmentation method we used was found to be reliable and easy to apply, but time-consuming technique for calculating BV.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"261 ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139170736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. bargi, Ayşe Sezgi Kızılırmak Karataş, Elif Şahin
Objective: Effectiveness of a 4-week telerehabilitation program including thoracic expansion exercises (TEE), non-specific general body exercises (NSGBE), and physical activity recommendations (PAR) which started at quarantine in individuals with acute mild-COVID-19 was investigated in current study. Methods: This is a randomized controlled study which was performed between May 2021 and February 2022. Adult individuals with acute mild-COVID-19 were randomly grouped as training (TG) (telerehabilitation program under supervision for 3 days/week) and control (CG) (home program including TEE and PAR). Dyspnea (Modified Borg Scale and Modified Medical Research Council Dyspnea Scale), chronic fatigue (Checklist Individual Strength Questionnaire), anxiety and depression (Hospital Anxiety and Depression Scale), balance (Berg Functional Balance Scale) and lower body strength (a 30-s chair stand test) were evaluated remotely in the individuals before and after a 4-week follow-up. Results: Baseline characteristics and balance scores were similar between groups (p>0.05). After 4-week from baseline, there were no significant differences in dyspnea, chronic fatigue, anxiety, depression, balance, and lower body strength between the groups (p>0.05). However, as dyspnea, chronic fatigue, anxiety, and depression scores decreased, lower body strength increased significantly within TG after follow-up (p<0.05). Dyspnea, chronic fatigue, and anxiety scores decreased while lower body strength increased significantly within CG after follow-up (p<0.05). Conclusion: Dyspnea, severe fatigue, anxiety, and depression are commonly observed in individuals with mild-COVID-19 in the acute period. In these individuals, dyspnea perception, chronic fatigue, anxiety, depression, and functional performance improve after a 4-week light-intensity online tele-program applied either supervised or unsupervised. Mild exercises and PAR are safe and effective in these individuals.
{"title":"Investigation of the Effects of Remote Online Exercise Training in Individuals Self-Isolating at Home Due to COVID-19 Disease: A Randomized Controlled Study","authors":"G. bargi, Ayşe Sezgi Kızılırmak Karataş, Elif Şahin","doi":"10.58600/eurjther1931","DOIUrl":"https://doi.org/10.58600/eurjther1931","url":null,"abstract":"Objective: Effectiveness of a 4-week telerehabilitation program including thoracic expansion exercises (TEE), non-specific general body exercises (NSGBE), and physical activity recommendations (PAR) which started at quarantine in individuals with acute mild-COVID-19 was investigated in current study.\u0000Methods: This is a randomized controlled study which was performed between May 2021 and February 2022. Adult individuals with acute mild-COVID-19 were randomly grouped as training (TG) (telerehabilitation program under supervision for 3 days/week) and control (CG) (home program including TEE and PAR). Dyspnea (Modified Borg Scale and Modified Medical Research Council Dyspnea Scale), chronic fatigue (Checklist Individual Strength Questionnaire), anxiety and depression (Hospital Anxiety and Depression Scale), balance (Berg Functional Balance Scale) and lower body strength (a 30-s chair stand test) were evaluated remotely in the individuals before and after a 4-week follow-up.\u0000Results: Baseline characteristics and balance scores were similar between groups (p>0.05). After 4-week from baseline, there were no significant differences in dyspnea, chronic fatigue, anxiety, depression, balance, and lower body strength between the groups (p>0.05). However, as dyspnea, chronic fatigue, anxiety, and depression scores decreased, lower body strength increased significantly within TG after follow-up (p<0.05). Dyspnea, chronic fatigue, and anxiety scores decreased while lower body strength increased significantly within CG after follow-up (p<0.05).\u0000Conclusion: Dyspnea, severe fatigue, anxiety, and depression are commonly observed in individuals with mild-COVID-19 in the acute period. In these individuals, dyspnea perception, chronic fatigue, anxiety, depression, and functional performance improve after a 4-week light-intensity online tele-program applied either supervised or unsupervised. Mild exercises and PAR are safe and effective in these individuals.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":" 921","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138960282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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