Dear Editors, I read your editorials with interest [1,2]. Artificial intelligence has become increasingly popular in recent years. Moreover, it is seen that valuable comments made on the article focus on issues such as potential harms in the academic use of artificial intelligence, publication ethics, and the ontological position of artificial intelligence [3-6]. As with other technological developments in our life, artificial intelligence seems to be increasingly present in our lives [7]. The use of artificial intelligence in article writing is a current topic of discussion. Writing an article from scratch with artificial intelligence doesn't seem quite right. The fact that artificial intelligence doesn't have an entirely independent thought structure, and that it obtains its information only based on the web, could lead to plagiarism. Also, it will not be fully understood whether it provides correct references and whether it violates the privacy of personal data. Furthermore, we do not find it correct to accept it as a co-author. Authorship carries a responsibility that an AI tool, no matter how advanced, cannot bear. Conversely, artificial intelligence will be incapable of assuming responsibility. So, should we stay away from artificial intelligence in this case? We believe the answer to this question is no. We can use artificial intelligence while writing an article, and it can facilitate our work. Finding a title after writing the article is an important issue. It must be impressive, and some journals have a character or word limit for the title. Artificial intelligence can help us in finding a title. Artificial intelligence can also assist in creating an abstract. Each journal has different rules about the abstract section. When rejected from one journal, it's necessary to create a new abstract for another journal. Artificial intelligence can speed up this process. When the article is ready, it needs to be checked for grammar and spelling rules. Artificial intelligence will be very useful in this situation. Preparing a good cover letter is important to attract the editor's attention. Artificial intelligence will assist in writing the cover letter. Although we think that artificial intelligence cannot be a co-author and cannot be used to write an article from scratch, we believe that we can benefit from artificial intelligence while writing our article. Using artificial intelligence will save us time. It will also help us write higher quality articles. In conclusion, artificial intelligence is now a part of our lives. Instead of avoiding it, we believe that we need to take advantage of artificial intelligence in a way that will facilitate our work. Sincerely yours,
{"title":"Harnessing Artificial Intelligence in Academic Writing: Potential, Ethics, and Responsible Use","authors":"Y. Duymaz, A. Tekin","doi":"10.58600/eurjther1755","DOIUrl":"https://doi.org/10.58600/eurjther1755","url":null,"abstract":"Dear Editors,\u0000I read your editorials with interest [1,2]. Artificial intelligence has become increasingly popular in recent years. Moreover, it is seen that valuable comments made on the article focus on issues such as potential harms in the academic use of artificial intelligence, publication ethics, and the ontological position of artificial intelligence [3-6].\u0000As with other technological developments in our life, artificial intelligence seems to be increasingly present in our lives [7]. The use of artificial intelligence in article writing is a current topic of discussion. Writing an article from scratch with artificial intelligence doesn't seem quite right. The fact that artificial intelligence doesn't have an entirely independent thought structure, and that it obtains its information only based on the web, could lead to plagiarism. Also, it will not be fully understood whether it provides correct references and whether it violates the privacy of personal data. Furthermore, we do not find it correct to accept it as a co-author. Authorship carries a responsibility that an AI tool, no matter how advanced, cannot bear. Conversely, artificial intelligence will be incapable of assuming responsibility. So, should we stay away from artificial intelligence in this case? We believe the answer to this question is no. We can use artificial intelligence while writing an article, and it can facilitate our work. Finding a title after writing the article is an important issue. It must be impressive, and some journals have a character or word limit for the title. Artificial intelligence can help us in finding a title. Artificial intelligence can also assist in creating an abstract. Each journal has different rules about the abstract section. When rejected from one journal, it's necessary to create a new abstract for another journal. Artificial intelligence can speed up this process. When the article is ready, it needs to be checked for grammar and spelling rules. Artificial intelligence will be very useful in this situation. Preparing a good cover letter is important to attract the editor's attention. Artificial intelligence will assist in writing the cover letter. Although we think that artificial intelligence cannot be a co-author and cannot be used to write an article from scratch, we believe that we can benefit from artificial intelligence while writing our article. Using artificial intelligence will save us time. It will also help us write higher quality articles.\u0000In conclusion, artificial intelligence is now a part of our lives. Instead of avoiding it, we believe that we need to take advantage of artificial intelligence in a way that will facilitate our work.\u0000Sincerely yours,","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"24 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89722017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Çağatay Küçükbingöz, Ayşe Bahşi, Tamer Bayram, Fidan Marufoglu, H. Özbek
Objectives: To investigate the effects of various durations of pulsed radiofrequency (PRF) application on pain and functional limitation in the short term in patients suffered from chronic shoulder pain Methods: 83 patients, 50 women (60.2%) and 33 men (39.8%) were included in the study. Treatment of PRF was implemented to the suprascapular nerve for 8 min in 44 (53.1%) and 10 min in 39 (46.9%) patients. The pain intensity of the patients was evaluated using the visual analog scale (VAS). The Shoulder Pain and Disability Index (SPADI) was utilized to define shoulder function and pain. VAS and SPADI measurements before and four weeks after treatment were recorded. Results: The VAS and SPADI scores showed a significant improvement in both treatment groups (P < 0.05); however, no significant difference was observed between the groups. Conclusion: Therefore, PRF is a beneficial treatment method in patients suffered from chronic shoulder pain; furthermore, the duration of PRF treatment of 8 or 10 minutes does not affect the effectiveness of the treatment.
{"title":"Comparison of the Effectiveness of Pulse Radiofrequency in the Treatment of Suprascapular Nerve in Chronic Shoulder Pain","authors":"Çağatay Küçükbingöz, Ayşe Bahşi, Tamer Bayram, Fidan Marufoglu, H. Özbek","doi":"10.58600/eurjther1707","DOIUrl":"https://doi.org/10.58600/eurjther1707","url":null,"abstract":"Objectives: To investigate the effects of various durations of pulsed radiofrequency (PRF) application on pain and functional limitation in the short term in patients suffered from chronic shoulder pain\u0000Methods: 83 patients, 50 women (60.2%) and 33 men (39.8%) were included in the study. Treatment of PRF was implemented to the suprascapular nerve for 8 min in 44 (53.1%) and 10 min in 39 (46.9%) patients. The pain intensity of the patients was evaluated using the visual analog scale (VAS). The Shoulder Pain and Disability Index (SPADI) was utilized to define shoulder function and pain. VAS and SPADI measurements before and four weeks after treatment were recorded.\u0000Results: The VAS and SPADI scores showed a significant improvement in both treatment groups (P < 0.05); however, no significant difference was observed between the groups.\u0000Conclusion: Therefore, PRF is a beneficial treatment method in patients suffered from chronic shoulder pain; furthermore, the duration of PRF treatment of 8 or 10 minutes does not affect the effectiveness of the treatment.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83573890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dear Editors, I found the content of your editorials to be highly intriguing [1,2]. Scientific journals are witnessing a growing prevalence of publications related to artificial intelligence (AI). Three letters to the editor were recently published in your journal [3-5]. The renowned journal Nature has dedicated approximately 25 publications solely to the subject of ChatGPT. Moreover, a quick search on Pubmed using the term "ChatGPT" yields around 900 articles, with the vast majority originating in 2023. These statistics underscore the substantial interest of the scientific community in this area. AI, especially the ChatGPT tool and the recent Bard, have faced criticism and been portrayed as significant adversaries of science. It is evident that many authors or researchers, who may not be well-versed in writing, can greatly benefit from these tools, as mentioned earlier. Without taking a contrarian stance, one should consider the potential advantages of such technologies for researchers in less privileged regions, where access to new technologies is limited, and local or regional challenges abound [6]. AI cannot be confounded with other technologies, as it specifically focuses on replicating human-like intelligence and decision-making processes, rather than simply automating tasks or improving performance based on data patterns. The translation into English poses challenges due to the dominance of English in worldwide publications, with over 95% of articles being published in this language, and even reaching 98% in some fields. Although this manuscript was partially translated using AI, it can still benefit researchers from non-native English regions. Even simple tasks like text editing can be problematic for researchers in underprivileged areas. AI can play a crucial role in the evolution of online lectures and classes, providing valuable support for African maxillofacial surgeons who lack the luxury of taking breaks from work to update their knowledge, as they may be the only available option [7]. One of the remarkable features of AI is its ability to discover knowledge gaps. The use of simple tools like reference organizers is rapidly evolving and can become automated or semi-automated through AI. However, we must carefully consider whether we should refrain from relying too heavily on AI in certain cases, as this could be seen as a significant regression. On the other hand, we must be cautious about freely allowing AI tools to circulate in scientific journals and books without proper regulation [8]. Currently, accurately identifying texts generated by AI is challenging, and their effectiveness remains relatively low, at less than 30%. This means that only about 30 out of every 100 texts can be confidently classified as AI-generated. The technology must advance further to increase detection accuracy or at least raise suspicion. Academic journals no longer view authors acknowledging artificial intelligence tools as co-authors in their research
{"title":"The Rising Tide of Artificial Intelligence in Scientific Journals: A Profound Shift in Research Landscape","authors":"R. Grillo","doi":"10.58600/eurjther1735","DOIUrl":"https://doi.org/10.58600/eurjther1735","url":null,"abstract":"Dear Editors,\u0000I found the content of your editorials to be highly intriguing [1,2]. Scientific journals are witnessing a growing prevalence of publications related to artificial intelligence (AI). Three letters to the editor were recently published in your journal [3-5]. The renowned journal Nature has dedicated approximately 25 publications solely to the subject of ChatGPT. Moreover, a quick search on Pubmed using the term \"ChatGPT\" yields around 900 articles, with the vast majority originating in 2023. These statistics underscore the substantial interest of the scientific community in this area.\u0000AI, especially the ChatGPT tool and the recent Bard, have faced criticism and been portrayed as significant adversaries of science. It is evident that many authors or researchers, who may not be well-versed in writing, can greatly benefit from these tools, as mentioned earlier. Without taking a contrarian stance, one should consider the potential advantages of such technologies for researchers in less privileged regions, where access to new technologies is limited, and local or regional challenges abound [6]. AI cannot be confounded with other technologies, as it specifically focuses on replicating human-like intelligence and decision-making processes, rather than simply automating tasks or improving performance based on data patterns.\u0000The translation into English poses challenges due to the dominance of English in worldwide publications, with over 95% of articles being published in this language, and even reaching 98% in some fields. Although this manuscript was partially translated using AI, it can still benefit researchers from non-native English regions. Even simple tasks like text editing can be problematic for researchers in underprivileged areas. AI can play a crucial role in the evolution of online lectures and classes, providing valuable support for African maxillofacial surgeons who lack the luxury of taking breaks from work to update their knowledge, as they may be the only available option [7]. One of the remarkable features of AI is its ability to discover knowledge gaps. The use of simple tools like reference organizers is rapidly evolving and can become automated or semi-automated through AI. However, we must carefully consider whether we should refrain from relying too heavily on AI in certain cases, as this could be seen as a significant regression.\u0000On the other hand, we must be cautious about freely allowing AI tools to circulate in scientific journals and books without proper regulation [8]. Currently, accurately identifying texts generated by AI is challenging, and their effectiveness remains relatively low, at less than 30%. This means that only about 30 out of every 100 texts can be confidently classified as AI-generated. The technology must advance further to increase detection accuracy or at least raise suspicion. Academic journals no longer view authors acknowledging artificial intelligence tools as co-authors in their research ","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"218 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77570422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Identifying and mapping the hotspots of the Cleft lip and palate (CLP) literature from 1980 to 2022, in addition it is aimed to present the results in a simplification. This article aims to offer an overview of pertinent research, examine prevailing research patterns, and stimulate appropriate areas for future investigation. Methods: In this scientometric research analysis, CLP publications between 1980 and 2022 were obtained from the Web of Science Core Collection database. The keywords "cleft lip and palate", "cleft lip, "cleft palate" and "oral cleft" were used in the search. CiteSpace, R-Studio (biblioshiny program) and Excel 2016 software were used for visualizations and analysis. Results: A total of 26,319 articles and 473,074 references were analyzed. The top 3 countries with the most publications were the United States (9,368 publications, 35.59% of the total), the United Kingdom (2,062, 7.83%), and Japan (1,786, 6.78%). After the co-citation clustering analysis, it was seen that the CLP literature was divided under 13 headings. The most influential articles were found with the citation burst analysis. Conclusion: Scientometric analysis study has been done in CLP's 42-year publication history. The results obtained present the general trend of the CLP literature, the topics on which the literature is divided, and the hot spots. With similar scientometric analysis studies to be carried out in the future, the progress of the literature can be followed and the future can be predicted.
{"title":"Scientometric Research Analysis of Cleft Lip and Palate Literature: Hot Spots, Most Influential Countries/Journals, History and Future","authors":"Y. Balel","doi":"10.58600/eurjther1680","DOIUrl":"https://doi.org/10.58600/eurjther1680","url":null,"abstract":"Objective: Identifying and mapping the hotspots of the Cleft lip and palate (CLP) literature from 1980 to 2022, in addition it is aimed to present the results in a simplification. This article aims to offer an overview of pertinent research, examine prevailing research patterns, and stimulate appropriate areas for future investigation.\u0000Methods: In this scientometric research analysis, CLP publications between 1980 and 2022 were obtained from the Web of Science Core Collection database. The keywords \"cleft lip and palate\", \"cleft lip, \"cleft palate\" and \"oral cleft\" were used in the search. CiteSpace, R-Studio (biblioshiny program) and Excel 2016 software were used for visualizations and analysis.\u0000Results: A total of 26,319 articles and 473,074 references were analyzed. The top 3 countries with the most publications were the United States (9,368 publications, 35.59% of the total), the United Kingdom (2,062, 7.83%), and Japan (1,786, 6.78%). After the co-citation clustering analysis, it was seen that the CLP literature was divided under 13 headings. The most influential articles were found with the citation burst analysis.\u0000Conclusion: Scientometric analysis study has been done in CLP's 42-year publication history. The results obtained present the general trend of the CLP literature, the topics on which the literature is divided, and the hot spots. With similar scientometric analysis studies to be carried out in the future, the progress of the literature can be followed and the future can be predicted.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"94 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84250517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Lung cancer is the most common cause of morbidity and mortality. Platinum-based chemotherapy, which is the primary line of treatment, offers limited benefit due to drug resistance and side effects. Berberine (BBR), which is characterised by its potent and safe anticancer activity, represents a promising combination option in chemotherapy. To overcome the limitations in lung cancer chemotherapy, we investigated whether BBR and cisplatin (CIS) exert synergistic effects on non-small cell lung cancer cell line (A549) based on cytotoxicity and apoptotic response markers. Methods: The potential cytotoxic effects of the combination treatment were evaluated using the MTT and Chou-Talalay methods. Elisa assays were also performed to measure the levels of the pro-apoptotic protein Bax and the effector protein caspase (Cas)-3. Results: The results showed that BBR alone reduced A549 cell viability in a dose-dependent manner and synergized with CIS (CI =0.34±0.05 at IC50 concentrations). Elisa results showed that the combined treatment (both at IC50 concentrations) modulated apoptotic signalling pathways in A549 cells. Bax and Cas3 protein levels were dramatically enhanced in A549 cells treated with CIS +BBR compared to control (0.5% DMSO) (p < 0.001). Conclusion: Our results suggest that BBR can synergistically enhance the therapeutic effect of CIS in A549 cells. The potential therapeutic efficacy of BBR as part of a combination in current chemotherapy should be supported by in-depth research and clinical studies on the molecular mechanisms associated with cancer.
{"title":"Berberine Synergizes with Cisplatin via Inducing Apoptosis on A549 non-Small Cell Lung Cancer Cells","authors":"Merve Becit-Kızılkaya, Şeyma Öncü, Serkan Şen, Sefa Çelik","doi":"10.58600/eurjther1703","DOIUrl":"https://doi.org/10.58600/eurjther1703","url":null,"abstract":"Objective: Lung cancer is the most common cause of morbidity and mortality. Platinum-based chemotherapy, which is the primary line of treatment, offers limited benefit due to drug resistance and side effects. Berberine (BBR), which is characterised by its potent and safe anticancer activity, represents a promising combination option in chemotherapy. To overcome the limitations in lung cancer chemotherapy, we investigated whether BBR and cisplatin (CIS) exert synergistic effects on non-small cell lung cancer cell line (A549) based on cytotoxicity and apoptotic response markers.\u0000Methods: The potential cytotoxic effects of the combination treatment were evaluated using the MTT and Chou-Talalay methods. Elisa assays were also performed to measure the levels of the pro-apoptotic protein Bax and the effector protein caspase (Cas)-3.\u0000Results: The results showed that BBR alone reduced A549 cell viability in a dose-dependent manner and synergized with CIS (CI =0.34±0.05 at IC50 concentrations). Elisa results showed that the combined treatment (both at IC50 concentrations) modulated apoptotic signalling pathways in A549 cells. Bax and Cas3 protein levels were dramatically enhanced in A549 cells treated with CIS +BBR compared to control (0.5% DMSO) (p < 0.001).\u0000Conclusion: Our results suggest that BBR can synergistically enhance the therapeutic effect of CIS in A549 cells. The potential therapeutic efficacy of BBR as part of a combination in current chemotherapy should be supported by in-depth research and clinical studies on the molecular mechanisms associated with cancer.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"124 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88095464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: It is still unclear to what extent kinesiophobia, dyspnea, pain, fatigue, mood, and balance are affected in adolescent volleyball players who have had COVID-19. Therefore, present study aimed to comparatively investigate kinesiophobia, dyspnea, pain, fatigue, depression, anxiety, stress, and balance between adolescent volleyball players with and without post-COVID-19. Methods: Adolescent volleyball players between ages of 10-19 (n=40) were included in the study between May 2022 and August 2022 and divided into those who have had COVID-19 (n=18) and those who have never had COVID-19 (n=22). Measurements of kinesiophobia (Tampa Scale of Kinesiophobia), dyspnea perception in daily living activities (Modified Medical Research Council Dyspnea Scale), severity of pain and fatigue (Numerical Rating Scale), depression, anxiety, and stress levels (Short Form of Depression Anxiety Stress Scale), static balance (balance test on one leg), and dynamic balance (standing functional reach test) were performed in all volleyball players at once. Results: There was no statistically significant difference between groups in demographic characteristics, kinesiophobia, dyspnea, pain, fatigue, depression, stress, and balance values (p>0.05). However, anxiety scores of adolescent volleyball players who have not had COVID-19 were statistically significantly higher than those of adolescent volleyball players who have experienced COVID-19 (p<0.05). The incidences of anxiety (n=5, 27.8% versus n=11, 50%) were similar between groups (p>0.05). Conclusions: During the prolonged COVID-19 pandemic period, kinesiophobia, dyspnea, pain and fatigue perceptions, depression, stress, and balance levels were found to be similar in adolescent volleyball players regardless of their post-COVID-19 status. However, anxiety is more common in adolescent volleyball players without post-COVID-19. Therefore, underlying causes of anxiety observed in adolescent volleyball players without post-COVID-19 should be investigated.
{"title":"Kinesiophobia, Dyspnea, Pain, Fatigue, Depression, Anxiety, Stress, and Balance in Adolescent Volleyball Players Who Have Had COVID-19","authors":"Elif Şahin, G. bargi","doi":"10.58600/eurjther1689","DOIUrl":"https://doi.org/10.58600/eurjther1689","url":null,"abstract":"Objectives: It is still unclear to what extent kinesiophobia, dyspnea, pain, fatigue, mood, and balance are affected in adolescent volleyball players who have had COVID-19. Therefore, present study aimed to comparatively investigate kinesiophobia, dyspnea, pain, fatigue, depression, anxiety, stress, and balance between adolescent volleyball players with and without post-COVID-19.\u0000Methods: Adolescent volleyball players between ages of 10-19 (n=40) were included in the study between May 2022 and August 2022 and divided into those who have had COVID-19 (n=18) and those who have never had COVID-19 (n=22). Measurements of kinesiophobia (Tampa Scale of Kinesiophobia), dyspnea perception in daily living activities (Modified Medical Research Council Dyspnea Scale), severity of pain and fatigue (Numerical Rating Scale), depression, anxiety, and stress levels (Short Form of Depression Anxiety Stress Scale), static balance (balance test on one leg), and dynamic balance (standing functional reach test) were performed in all volleyball players at once.\u0000Results: There was no statistically significant difference between groups in demographic characteristics, kinesiophobia, dyspnea, pain, fatigue, depression, stress, and balance values (p>0.05). However, anxiety scores of adolescent volleyball players who have not had COVID-19 were statistically significantly higher than those of adolescent volleyball players who have experienced COVID-19 (p<0.05). The incidences of anxiety (n=5, 27.8% versus n=11, 50%) were similar between groups (p>0.05).\u0000Conclusions: During the prolonged COVID-19 pandemic period, kinesiophobia, dyspnea, pain and fatigue perceptions, depression, stress, and balance levels were found to be similar in adolescent volleyball players regardless of their post-COVID-19 status. However, anxiety is more common in adolescent volleyball players without post-COVID-19. Therefore, underlying causes of anxiety observed in adolescent volleyball players without post-COVID-19 should be investigated.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83387789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saliha Yavuz Eravcı, Sevinç Çelik, B. Çalışkan, Fayize Maden Bedel, A. Canbal, Nagehan Bilgeç, Hayriye Nermin Keçeci, A. Güven, H. Çaksen
Objective: To evaluate the clinical status of epilepsy, which is extremely widespread in tuberosclerosis patients and the findings and characteristics of a paediatric case series. Methods: The study included paediatric patients diagnosed with tuberosclerosis from clinical or genetic examination who were followed up between 2015 and 2022 in the Paediatric Neurology and Paediatric Genetics Clinics of Necmettin Erbakan University Meram Medical Faculty Hospital. A retrospective examination was made of the clinical characteristics of the patients, the electroencepahalography (EEG) reports, and radiological findings (magnetic resonance imaging [MRI], ultrasonography, echocardiography). The patients were separated into two groups of monotherapy and polytherapy according to the number of drugs used, and the groups were compared in respect of the time of onset of epilepsy. The patients were also categorised according to the presence of cortical tuber and subependymal nodule and these groups were compared in respect of the presence of epilepsy. Results: The 27 patients comprised 18 (66.6%) males and 9 (33.4%) females. Complaints on presentation were seizure and skin patches in 25 (92.5%) cases and only skin patches in 2 (7.5%). The most common finding determined on MRI was the combination of subependymal nodule and cortical tuber (51.8%). Autism spectrum disorder was present in 5 (18.5%) patients and mental retardation in 16 (59%). The age at onset of epilepsy was earlier in the polytherapy group [5±4.75 (1-18) months] than in the monotherapy group [8.0±16 (4-36) months] (p=0.032). The rates of presence of cortical tuber and subependymal nodule were similar in respect of the time of onset of epilepsy (p>0.05). Conclusion: The early onset of epilepsy in tubersclerosis patients indicates that it may have a resistant course and there may be a need for polytherapy. There may also be accompanying neuropsychiatric retardation in these patients. The clinical status of epilepsy in tuberosclerosis was found to be similar in the cortical tuber and subependymal nodule groups.
{"title":"The Effect of the Age at Seizure Onset on Seizure Resistance in Tuberosclerosis Patients","authors":"Saliha Yavuz Eravcı, Sevinç Çelik, B. Çalışkan, Fayize Maden Bedel, A. Canbal, Nagehan Bilgeç, Hayriye Nermin Keçeci, A. Güven, H. Çaksen","doi":"10.58600/eurjther1668","DOIUrl":"https://doi.org/10.58600/eurjther1668","url":null,"abstract":"Objective: To evaluate the clinical status of epilepsy, which is extremely widespread in tuberosclerosis patients and the findings and characteristics of a paediatric case series.\u0000Methods: The study included paediatric patients diagnosed with tuberosclerosis from clinical or genetic examination who were followed up between 2015 and 2022 in the Paediatric Neurology and Paediatric Genetics Clinics of Necmettin Erbakan University Meram Medical Faculty Hospital. A retrospective examination was made of the clinical characteristics of the patients, the electroencepahalography (EEG) reports, and radiological findings (magnetic resonance imaging [MRI], ultrasonography, echocardiography). The patients were separated into two groups of monotherapy and polytherapy according to the number of drugs used, and the groups were compared in respect of the time of onset of epilepsy. The patients were also categorised according to the presence of cortical tuber and subependymal nodule and these groups were compared in respect of the presence of epilepsy.\u0000Results: The 27 patients comprised 18 (66.6%) males and 9 (33.4%) females. Complaints on presentation were seizure and skin patches in 25 (92.5%) cases and only skin patches in 2 (7.5%). The most common finding determined on MRI was the combination of subependymal nodule and cortical tuber (51.8%). Autism spectrum disorder was present in 5 (18.5%) patients and mental retardation in 16 (59%). The age at onset of epilepsy was earlier in the polytherapy group [5±4.75 (1-18) months] than in the monotherapy group [8.0±16 (4-36) months] (p=0.032). The rates of presence of cortical tuber and subependymal nodule were similar in respect of the time of onset of epilepsy (p>0.05).\u0000Conclusion: The early onset of epilepsy in tubersclerosis patients indicates that it may have a resistant course and there may be a need for polytherapy. There may also be accompanying neuropsychiatric retardation in these patients. The clinical status of epilepsy in tuberosclerosis was found to be similar in the cortical tuber and subependymal nodule groups.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"8 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85440432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Karangelis, Konstantinos C. Christodoulou, E. Georgakarakos, A. Fiska, D. Mikroulis
As doctors increasingly rely on technological advancements, ever-improving laboratory techniques, and imaging modalities, the importance of a thorough physical evaluation and bedside manner has been noticeably diminished. When it comes to patients scheduled for coronary artery bypass graft (CABG), the preoperative bilateral arm blood pressure (BP) measurement is often omitted; thus, sinister signs of atherosclerotic disease like the brachial gradient are neglected and the surgical plan is jeopardized. We present the case of a 72-year-old male listed for CABG, stressing the necessity of meticulous clinical examination and the routine use of color Doppler ultrasonography (CDUS), prior to surgery. This case aims to highlight the major role of thorough preoperative clinical assessment. The bilateral BP measurement and CDUS are two reliable, expeditious, noninvasive preoperative screening methods, which can detect patients with generalized atherosclerosis, altering, if necessary, the surgical plan, and aiming for the best possible outcome, without complications.
{"title":"Preoperative Assessment for Coronary Artery Bypass Graft: Going Back to the Basics","authors":"D. Karangelis, Konstantinos C. Christodoulou, E. Georgakarakos, A. Fiska, D. Mikroulis","doi":"10.58600/eurjther1704","DOIUrl":"https://doi.org/10.58600/eurjther1704","url":null,"abstract":"As doctors increasingly rely on technological advancements, ever-improving laboratory techniques, and imaging modalities, the importance of a thorough physical evaluation and bedside manner has been noticeably diminished. When it comes to patients scheduled for coronary artery bypass graft (CABG), the preoperative bilateral arm blood pressure (BP) measurement is often omitted; thus, sinister signs of atherosclerotic disease like the brachial gradient are neglected and the surgical plan is jeopardized. We present the case of a 72-year-old male listed for CABG, stressing the necessity of meticulous clinical examination and the routine use of color Doppler ultrasonography (CDUS), prior to surgery. This case aims to highlight the major role of thorough preoperative clinical assessment. The bilateral BP measurement and CDUS are two reliable, expeditious, noninvasive preoperative screening methods, which can detect patients with generalized atherosclerosis, altering, if necessary, the surgical plan, and aiming for the best possible outcome, without complications.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"39 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82327979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ayse Sumeyye Demir Gungor, C. Kabaca, S. Akış, E. Ergen
Objective: To investigate the importance of preoperative cervical Pap smear in patients with endometrial cancer and the impact of it on the prognostic risk groups of endometrial cancer. Methods: The preoperative cervical cytology results of 423 patients who underwent staging surgery for endometrial cancer between the years of 2010 and 2020 in the gynecological oncology clinic of the tertiary center were examined in a retrospective observational study. The relations between cervical Pap smear results and pathological prognostic factors of endometrial cancer such as tumor histology, tumor size, FIGO grade, lymphovascular space invasion and FIGO stage were evaluated in details. The impact of cervical cytology results in the prognostic risk groups (molecular classification unknown) specified in the ESGO/ESTRO/ESP (2020) guideline was also examined. SPSS version 25.0 program was used in the analysis of the data. Results: Abnormal cervical Pap cytology was present in 12.1% (n= 51) of the patients included in the study. Significantly more abnormal cervical cytology was observed in the high prognostic risk groups (p= 0.017), tumors with non-endometrioid histologic types (p= 0.001), and patients with adnexal involvement (p= 0.007). In the subgroup analysis of endometrioid type endometrial adenocarcinomas, as the FIGO grade increased, the rate of abnormal cervical cytology increased significantly (p= 0.014). Conclusions: Pre-operative cervical cytology abnormality may predict the need for intra-operative systematic surgical staging and postoperative adjuvant therapy.
{"title":"The Impact of Cervical Pap Smear on the Prognostic Risk Groups of Endometrial Carcinoma","authors":"Ayse Sumeyye Demir Gungor, C. Kabaca, S. Akış, E. Ergen","doi":"10.58600/eurjther1705","DOIUrl":"https://doi.org/10.58600/eurjther1705","url":null,"abstract":"Objective: To investigate the importance of preoperative cervical Pap smear in patients with endometrial cancer and the impact of it on the prognostic risk groups of endometrial cancer.\u0000Methods: The preoperative cervical cytology results of 423 patients who underwent staging surgery for endometrial cancer between the years of 2010 and 2020 in the gynecological oncology clinic of the tertiary center were examined in a retrospective observational study. The relations between cervical Pap smear results and pathological prognostic factors of endometrial cancer such as tumor histology, tumor size, FIGO grade, lymphovascular space invasion and FIGO stage were evaluated in details. The impact of cervical cytology results in the prognostic risk groups (molecular classification unknown) specified in the ESGO/ESTRO/ESP (2020) guideline was also examined. SPSS version 25.0 program was used in the analysis of the data.\u0000Results: Abnormal cervical Pap cytology was present in 12.1% (n= 51) of the patients included in the study. Significantly more abnormal cervical cytology was observed in the high prognostic risk groups (p= 0.017), tumors with non-endometrioid histologic types (p= 0.001), and patients with adnexal involvement (p= 0.007). In the subgroup analysis of endometrioid type endometrial adenocarcinomas, as the FIGO grade increased, the rate of abnormal cervical cytology increased significantly (p= 0.014).\u0000Conclusions: Pre-operative cervical cytology abnormality may predict the need for intra-operative systematic surgical staging and postoperative adjuvant therapy.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"73 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77840659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jayalakshmi Srinivasan, Dr. Neha Singh, Dr. Nidhi Anam, Snehal Wagh, Shubhangi Sharma
A 42-year-old female patient was admitted to the hospital with moderate-grade fever, severe headache, loss of appetite, and sore throat. She was suspected of Meningitis and her CSF sample was sent to the Laboratory for Microbiological Examination. The CSF sample obtained showed the presence of Capsulated budding yeast cells on India Ink Examination and Cryptococcus neoformans was isolated on SDA culture. The patient was recently diagnosed as HIV-Sero Positive and was immunocompromised leading to acquiring Cryptococcal meningitis. The lack of awareness of HIV-AIDS and delayed diagnosis of Cryptococcal meningitis led to a poor prognosis. Early diagnosis of HIV and timely treatment can improve the prognosis of the disease.
{"title":"Cryptococcal Meningitis in a Human Immunodeficiency Virus Sero-positive Patient: A Case Study","authors":"Jayalakshmi Srinivasan, Dr. Neha Singh, Dr. Nidhi Anam, Snehal Wagh, Shubhangi Sharma","doi":"10.58600/eurjther1657","DOIUrl":"https://doi.org/10.58600/eurjther1657","url":null,"abstract":"A 42-year-old female patient was admitted to the hospital with moderate-grade fever, severe headache, loss of appetite, and sore throat. She was suspected of Meningitis and her CSF sample was sent to the Laboratory for Microbiological Examination. The CSF sample obtained showed the presence of Capsulated budding yeast cells on India Ink Examination and Cryptococcus neoformans was isolated on SDA culture. The patient was recently diagnosed as HIV-Sero Positive and was immunocompromised leading to acquiring Cryptococcal meningitis. The lack of awareness of HIV-AIDS and delayed diagnosis of Cryptococcal meningitis led to a poor prognosis. Early diagnosis of HIV and timely treatment can improve the prognosis of the disease.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"27 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90590144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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