MD Erkan Ozduran, V. Hancı, Özlem Öner, E. Özduran, Erol Gökel
Introduction: Percutaneous tracheostomy one of the most common interventional procedures in the intensive care unit. The aim of our study is to investigate “Youtube ® ” videos about percutaneous tracheostomy in the intensive care unit in terms of the information value and quality they provide. Material and Method: Video search was performed on the “YouTube.com” in November 2021 with the “percutaneous tracheostomy” search key. The first 100 videos about percutaneous tracheostomy in the intensive care unit were listed and the number of views, likes, dislikes, comments, uploaded source, source country and continent were determined, and content analyzes were made. The quality, reliability and accuracy of the videos were determined by the "Global Quality Score"(GQS), "Journal of American Medical Association (JAMA) Quality Test" and "Modified DISCERN" questionnaire, respectively. Results: According to GQS, 45 low, 31 medium and 24 high quality videos were detected. 72 of the videos contained insufficient, 25 partially sufficient and 3 completely sufficient data. Academic and doctor-sourced videos comprised the majority (70,83%) of the high-quality group. There was no significant relationship between video sources, GQS, JAMA score, Modified DISCERN score and the number of views, likes, dislikes and comments(p>0,05). A weak positive correlation was found between video duration and GQS(r=0,206), JAMA(r=0.263), modified DISCERN(r=0,388) scores(p<0,05). Conclusion: According to our results, it was determined that most of the youtube videos about percutaneous tracheostomy in the intensive care unit were of poor quality and had insufficient data. It has been determined that high-quality videos are of longer duration and are uploaded by academic and doctor sources.
{"title":"Youtube as a source of information about Percutan Tracheostomy","authors":"MD Erkan Ozduran, V. Hancı, Özlem Öner, E. Özduran, Erol Gökel","doi":"10.12996/gmj.2023.77","DOIUrl":"https://doi.org/10.12996/gmj.2023.77","url":null,"abstract":"Introduction: Percutaneous tracheostomy one of the most common interventional procedures in the intensive care unit. The aim of our study is to investigate “Youtube ® ” videos about percutaneous tracheostomy in the intensive care unit in terms of the information value and quality they provide. Material and Method: Video search was performed on the “YouTube.com” in November 2021 with the “percutaneous tracheostomy” search key. The first 100 videos about percutaneous tracheostomy in the intensive care unit were listed and the number of views, likes, dislikes, comments, uploaded source, source country and continent were determined, and content analyzes were made. The quality, reliability and accuracy of the videos were determined by the \"Global Quality Score\"(GQS), \"Journal of American Medical Association (JAMA) Quality Test\" and \"Modified DISCERN\" questionnaire, respectively. Results: According to GQS, 45 low, 31 medium and 24 high quality videos were detected. 72 of the videos contained insufficient, 25 partially sufficient and 3 completely sufficient data. Academic and doctor-sourced videos comprised the majority (70,83%) of the high-quality group. There was no significant relationship between video sources, GQS, JAMA score, Modified DISCERN score and the number of views, likes, dislikes and comments(p>0,05). A weak positive correlation was found between video duration and GQS(r=0,206), JAMA(r=0.263), modified DISCERN(r=0,388) scores(p<0,05). Conclusion: According to our results, it was determined that most of the youtube videos about percutaneous tracheostomy in the intensive care unit were of poor quality and had insufficient data. It has been determined that high-quality videos are of longer duration and are uploaded by academic and doctor sources.","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44941992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tiroid Nodüllerinin, Tanısında Cerrah, Tarafından Gerçekleştirilen, Ultrason Kılavuzluğunda, İnce İğne, Aspirasyon Sitolojisinin, Kullanışlılığı Chang, Haur Lee, Christina Poh, Sim Loo, Yung Jeat Ng, Kah Yee, Siti Ho, Zubaidah Sharif
Background: The incidence of thyroid malignancy is increasing globally and this results in the growing number of patients facing increasing wait times for ultrasound (US) guided fine needle aspiration cytology (FNAC) for diagnosis. The objective of this study is to investigate the accuracy of surgeon performed US guided FNAC of thyroid nodules in the outpatient setting. Methods: This was a retrospective cross-sectional study on patients who underwent US guided FNAC followed by thyroidectomy between July 2019 and September 2022. US TI-RADS grade, FNAC Bethesda category and final histology were obtained from medical records and analysed. Result: There were 122 biopsy samples from 103 patients with a female gender preponderance of 89.3% and mean age of 46.5 years old. The majority of nodules biopsied were TI-RADS 4 and 5 (44.3% and 37.7%). Of the FNAC samples, 13.1% were non diagnostic, 27.9% benign, 14.7% atypia, 14.7% follicular neoplasm, 16.4% suspicious of malignancy and 13.1% were malignant. On final histology, adenomatoid nodules with nodular hyperplasia made up 82.5% of benign nodules and 94.9% of malignancies were papillary thyroid carcinomas (PTC). The overall sensitivity, specificity, positive predictive value, negative predictive value and accuracy were 88.9%, 82.4%, 84.2%, 87.5% and 85.7% with higher accuracy rate (90.1%) when used in TI-RADS 5 nodules. Conclusion: Surgeon performed US guided FNAC for thyroid nodules is feasible and can be done in the outpatient setting thereby reducing time taken to reach a diagnosis. Standardizing techniques and use of additional modalities such as elastography may improve yield and diagnostic rates.
{"title":"Utility of Surgeon Performed Ultrasound Guided Fine Needle Aspiration Cytology for Diagnosis of Thyroid Nodules","authors":"Tiroid Nodüllerinin, Tanısında Cerrah, Tarafından Gerçekleştirilen, Ultrason Kılavuzluğunda, İnce İğne, Aspirasyon Sitolojisinin, Kullanışlılığı Chang, Haur Lee, Christina Poh, Sim Loo, Yung Jeat Ng, Kah Yee, Siti Ho, Zubaidah Sharif","doi":"10.12996/gmj.2023.83","DOIUrl":"https://doi.org/10.12996/gmj.2023.83","url":null,"abstract":"Background: The incidence of thyroid malignancy is increasing globally and this results in the growing number of patients facing increasing wait times for ultrasound (US) guided fine needle aspiration cytology (FNAC) for diagnosis. The objective of this study is to investigate the accuracy of surgeon performed US guided FNAC of thyroid nodules in the outpatient setting. Methods: This was a retrospective cross-sectional study on patients who underwent US guided FNAC followed by thyroidectomy between July 2019 and September 2022. US TI-RADS grade, FNAC Bethesda category and final histology were obtained from medical records and analysed. Result: There were 122 biopsy samples from 103 patients with a female gender preponderance of 89.3% and mean age of 46.5 years old. The majority of nodules biopsied were TI-RADS 4 and 5 (44.3% and 37.7%). Of the FNAC samples, 13.1% were non diagnostic, 27.9% benign, 14.7% atypia, 14.7% follicular neoplasm, 16.4% suspicious of malignancy and 13.1% were malignant. On final histology, adenomatoid nodules with nodular hyperplasia made up 82.5% of benign nodules and 94.9% of malignancies were papillary thyroid carcinomas (PTC). The overall sensitivity, specificity, positive predictive value, negative predictive value and accuracy were 88.9%, 82.4%, 84.2%, 87.5% and 85.7% with higher accuracy rate (90.1%) when used in TI-RADS 5 nodules. Conclusion: Surgeon performed US guided FNAC for thyroid nodules is feasible and can be done in the outpatient setting thereby reducing time taken to reach a diagnosis. Standardizing techniques and use of additional modalities such as elastography may improve yield and diagnostic rates.","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46121907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gebelerin Aşı, Tereddütlerinin ve, Aşılanma Davranışlarının, Belirlenmesi Neslihan, Yilmaz Sezer, Derya Öztürk Özen, M. N. Aker
Objective: Vaccination during pregnancy is important for both maternal and fetal/newborn health. The aim of this study was to examine the vaccination behaviors and levels of vaccine hesitancy among pregnant women. Methods: This descriptive study involved 518 pregnant women. Data were collected between March and May 2022, utilizing demographic information form and the Vaccine Hesitancy Scale (VHS). Results: The mean VHS score was found to be 31.92±4.68. The rate of vaccine hesitancy among pregnant women was determined to be 31.5%. The mean score for lack of confidence was 25.63±4.10, while the mean score for perceived risks was 6.29±1.50. Pregnant women who received information about vaccination during pregnancy from healthcare professionals had higher mean scores on the VHS, as well as on the lack of confidence and perceived risks sub-dimensions, compared to those who did not receive such information (p<.05). Of the pregnant women, 86.3% had received/were planning to receive tetanus vaccine, at least 1 dose of COVID-19 vaccine had been received by 61.8% before pregnancy and by 11.8% during pregnancy, and 37.5% had received/were planning to receive hepatitis B vaccine.The vaccine hesitancy of pregnant women who had received the COVID-19 vaccine before pregnancy, as well as those who had received or were planning to receive the tetanus and hepatitis B vaccines during pregnancy, was lower compared to those who had not received these vaccines(p<.05). Conclusions: As the vaccine hesitancy of pregnant women increased, their vaccination decreased. Healthcare providers catering to pregnant individuals should assess and address hesitancy, ensuring timely vaccinations.
{"title":"Determination of the Vaccination Hesitations and Vaccination Behaviors of the Pregnant Women","authors":"Gebelerin Aşı, Tereddütlerinin ve, Aşılanma Davranışlarının, Belirlenmesi Neslihan, Yilmaz Sezer, Derya Öztürk Özen, M. N. Aker","doi":"10.12996/gmj.2023.88","DOIUrl":"https://doi.org/10.12996/gmj.2023.88","url":null,"abstract":"Objective: Vaccination during pregnancy is important for both maternal and fetal/newborn health. The aim of this study was to examine the vaccination behaviors and levels of vaccine hesitancy among pregnant women. Methods: This descriptive study involved 518 pregnant women. Data were collected between March and May 2022, utilizing demographic information form and the Vaccine Hesitancy Scale (VHS). Results: The mean VHS score was found to be 31.92±4.68. The rate of vaccine hesitancy among pregnant women was determined to be 31.5%. The mean score for lack of confidence was 25.63±4.10, while the mean score for perceived risks was 6.29±1.50. Pregnant women who received information about vaccination during pregnancy from healthcare professionals had higher mean scores on the VHS, as well as on the lack of confidence and perceived risks sub-dimensions, compared to those who did not receive such information (p<.05). Of the pregnant women, 86.3% had received/were planning to receive tetanus vaccine, at least 1 dose of COVID-19 vaccine had been received by 61.8% before pregnancy and by 11.8% during pregnancy, and 37.5% had received/were planning to receive hepatitis B vaccine.The vaccine hesitancy of pregnant women who had received the COVID-19 vaccine before pregnancy, as well as those who had received or were planning to receive the tetanus and hepatitis B vaccines during pregnancy, was lower compared to those who had not received these vaccines(p<.05). Conclusions: As the vaccine hesitancy of pregnant women increased, their vaccination decreased. Healthcare providers catering to pregnant individuals should assess and address hesitancy, ensuring timely vaccinations.","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45288856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Sanaie, Behnam Sadigi, Reza Yarani, Nikolaj Travica, Zahra Yousefi, S. Shakouri, Alireza Ostadrahimi, M. Mobasseri, Fateme Tahmasbi, Mostafa Araj-khodaei
Aim: Diabetes mellitus is a chronic medical condition characterized by an accumulation of glucose in the bloodstream. Specifically, type 2 diabetes occurs when the body’s cells are unable to efficiently respond to insulin, the hormone responsible for transporting circulatory glucose into cells. In the advanced stages of the disease, the body may also not produce sufficient amounts of insulin. As the disease progresses, the symptoms become more severe and potentially lead to a series of comorbidities. Although several medications are used to treat and control type 2 diabetes, these medications may have serious side effects. Hence, the use of herbal medicine to alleviate type 2 diabetes has been studied and has attracted widespread interest. Our major goal is to examine these herbs' effectiveness and related mechanisms of action in treating type 2 diabetes. Method : We studied worldwide traditional medicines, old texts, and published literature for anti-diabetic effect of Melissa officinalis and saffron. Electronic databases comprising PubMed, Web of Science, Science Direct, Scopus and Google Scholar were searched to collect articles published between 1990 and 2022 years. Results : We confirmed that a variety of herbal therapies, including saffron and lemon balm (Melissa officinalis), had anti-diabetic activities based on the findings of various research. Conclusion: Saffron and Melissa officinalis have anti-diabetic properties.
目的：糖尿病是一种以血液中葡萄糖积聚为特征的慢性疾病。具体来说，当身体细胞无法有效地对胰岛素做出反应时，就会发生2型糖尿病，胰岛素是负责将循环葡萄糖输送到细胞中的激素。在疾病的晚期，身体也可能无法产生足够量的胰岛素。随着疾病的发展，症状变得更加严重，并可能导致一系列合并症。尽管有几种药物用于治疗和控制2型糖尿病，但这些药物可能会产生严重的副作用。因此，使用草药来缓解2型糖尿病已经得到了研究，并引起了广泛的兴趣。我们的主要目标是检查这些草药在治疗2型糖尿病方面的有效性和相关作用机制。方法：我们研究了世界各地的传统药物、旧文献和已发表的文献中关于梅丽莎·officinalis和藏红花抗糖尿病的作用。搜索包括PubMed、Web of Science、Science Direct、Scopus和Google Scholar在内的电子数据库，以收集1990年至2022年间发表的文章。结果：根据各种研究结果，我们证实了包括藏红花和柠檬风油精（Melissa officinalis）在内的多种草药疗法具有抗糖尿病活性。结论：藏红花和梅丽莎具有抗糖尿病作用。
{"title":"Anti-diabetic Properties of Melissa officinalis and Saffron: Recent Advances and Discoveries","authors":"S. Sanaie, Behnam Sadigi, Reza Yarani, Nikolaj Travica, Zahra Yousefi, S. Shakouri, Alireza Ostadrahimi, M. Mobasseri, Fateme Tahmasbi, Mostafa Araj-khodaei","doi":"10.12996/gmj.2023.93","DOIUrl":"https://doi.org/10.12996/gmj.2023.93","url":null,"abstract":"Aim: Diabetes mellitus is a chronic medical condition characterized by an accumulation of glucose in the bloodstream. Specifically, type 2 diabetes occurs when the body’s cells are unable to efficiently respond to insulin, the hormone responsible for transporting circulatory glucose into cells. In the advanced stages of the disease, the body may also not produce sufficient amounts of insulin. As the disease progresses, the symptoms become more severe and potentially lead to a series of comorbidities. Although several medications are used to treat and control type 2 diabetes, these medications may have serious side effects. Hence, the use of herbal medicine to alleviate type 2 diabetes has been studied and has attracted widespread interest. Our major goal is to examine these herbs' effectiveness and related mechanisms of action in treating type 2 diabetes. Method : We studied worldwide traditional medicines, old texts, and published literature for anti-diabetic effect of Melissa officinalis and saffron. Electronic databases comprising PubMed, Web of Science, Science Direct, Scopus and Google Scholar were searched to collect articles published between 1990 and 2022 years. Results : We confirmed that a variety of herbal therapies, including saffron and lemon balm (Melissa officinalis), had anti-diabetic activities based on the findings of various research. Conclusion: Saffron and Melissa officinalis have anti-diabetic properties.","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47195144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Gönenç, Ali Eraydın, Tuba Taşkan, T. Turan, Reyhan Ersoy
Objective: Growth Arrest Specific-6 is the ligand of the Tyro, Axl, and Mer (TAM) receptors subfamily of the receptor tyrosine kinase family. Gas6/Axl signaling pathway is highly regulated in several pathological conditions. The role of Gas6/Axl signaling in hypothyroidism and hyperthyroidism has not been explored previously. In this study, we aim to investigate possible changes in plasma Gas6 and Axl levels in patients with hyperthyroidism and hypothyroidism. Methods: In the study, 33 patients who were diagnosed with hypothyroidism, 35 patients who were diagnosed with hyperthyroidism and 36 healthy volunteers were included as the control group. Gas6, Axl, IL-6, TNF-α, and AOPP levels in plasma were measured with ELISA kits, MDA and TAC levels were measured with colorimetric kits. Results: The plasma Axl level of the hyperthyroid patient group was significantly higher than control group (p<0.05). MDA levels were significantly higher in both hyperthyroid and hypothyroid patient groups compared to the controls (p<0.01, p<0.01, respectively). Plasma TAC level were found to be significantly lower, while AOPP were higher than controls in hyperthyroid group (p<0.05, p<0.05 respectively). In all groups, Gas6 and Axl have positive correlations, both among themselves and with IL-6 and TNF-α levels. Conclusion: Our results support the hypothesis that the Gas6/Axl signaling pathway may be involved in the pathogenesis of these diseases. In addition, it can be thought that lipid peroxidation increases and antioxidant defense is impaired in both hyperthyroidism and hypothyroidism.
{"title":"Plasma Growth Arrest Specific-6 and Axl Levels in Patients with Hyperthyroidism / Hypothyroidism","authors":"A. Gönenç, Ali Eraydın, Tuba Taşkan, T. Turan, Reyhan Ersoy","doi":"10.12996/gmj.2023.81","DOIUrl":"https://doi.org/10.12996/gmj.2023.81","url":null,"abstract":"Objective: Growth Arrest Specific-6 is the ligand of the Tyro, Axl, and Mer (TAM) receptors subfamily of the receptor tyrosine kinase family. Gas6/Axl signaling pathway is highly regulated in several pathological conditions. The role of Gas6/Axl signaling in hypothyroidism and hyperthyroidism has not been explored previously. In this study, we aim to investigate possible changes in plasma Gas6 and Axl levels in patients with hyperthyroidism and hypothyroidism. Methods: In the study, 33 patients who were diagnosed with hypothyroidism, 35 patients who were diagnosed with hyperthyroidism and 36 healthy volunteers were included as the control group. Gas6, Axl, IL-6, TNF-α, and AOPP levels in plasma were measured with ELISA kits, MDA and TAC levels were measured with colorimetric kits. Results: The plasma Axl level of the hyperthyroid patient group was significantly higher than control group (p<0.05). MDA levels were significantly higher in both hyperthyroid and hypothyroid patient groups compared to the controls (p<0.01, p<0.01, respectively). Plasma TAC level were found to be significantly lower, while AOPP were higher than controls in hyperthyroid group (p<0.05, p<0.05 respectively). In all groups, Gas6 and Axl have positive correlations, both among themselves and with IL-6 and TNF-α levels. Conclusion: Our results support the hypothesis that the Gas6/Axl signaling pathway may be involved in the pathogenesis of these diseases. In addition, it can be thought that lipid peroxidation increases and antioxidant defense is impaired in both hyperthyroidism and hypothyroidism.","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44473867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Deniz Gezgin, Sevcan A Yildirim¹, Bakkaloglu, Rutin Laboratuvar, Parametreleri Behçet, Hastalığı olan, Çocuklarda Hastalık, Aktivitesini Öngörüyor
Objective. Juvenile Behçet’s disease (jBD) is a multi-systemic inflammatory disorder characterized by recurrent episodes of oral and genital aphthae, and cutaneous, gastrointestinal, neurological, articular, ocular and vascular manifestations. The main aim of this study was to assess the value of routine laboratory parameters for predicting disease activity in children with jBD. Methods. The demographic features and laboratory findings, including white blood cell, neutrophil (NEU), lymphocyte (LYM) and platelet (PLT) counts, neutrophil/ lymphocyte ratio (NLR), platelet/ lymphocyte ratio (PLR), mean platelet volume/platelet ratio (MPR) values were retrospectively evaluated between jBD patients with active and inactive, and compared with those in healthy peers. Inactive jBD was accepted as the absence of any clinical symptoms, while active jBD was accepted as presence of at least two clinical symptoms related with jBD. Results. Thirty six patients with jBD, and 58 sex-and age-matched healthy children were enrolled into this study. Median age at diagnosis of jBD was 13 (min – max: 5-17) years. 12 patients had active and remaining 24 inactive disease at enrollment. Active jBD group had significantly higher mean values for NLR, PLR, and lower MPV compared to inactive patients (p= 0.026, p= 0.039, and p= 0.07, respectively). PLR was revealed as an independent factor for predicting disease activity in jBD patients (p= 0.035, OR [95% Cl] = 0.988 [0.978-0.999]). Conclusion. This study has shown that active jBD patients had increased values of NLR and PLR. Among them PLR was the possible risk predictor for disease activity. These parameters are easily accessible inflammatory markers that may help detecting active disease in the early phase to prevent complications and to guide the therapy.
目标。青少年behet病(jBD)是一种多系统炎症性疾病，其特征是口腔和生殖器溃疡的反复发作，以及皮肤、胃肠、神经、关节、眼部和血管的表现。本研究的主要目的是评估常规实验室参数对预测jBD患儿疾病活动性的价值。方法。回顾性评价活动性和非活动性jBD患者的人口统计学特征和实验室检查结果，包括白细胞、中性粒细胞(NEU)、淋巴细胞(LYM)和血小板(PLT)计数、中性粒细胞/淋巴细胞比率(NLR)、血小板/淋巴细胞比率(PLR)、平均血小板体积/血小板比率(MPR)值，并与健康同龄人进行比较。非活动性jBD被接受为没有任何临床症状，而活动性jBD被接受为存在至少两种与jBD相关的临床症状。结果。36名jBD患者和58名性别和年龄匹配的健康儿童参加了这项研究。诊断为jBD的中位年龄为13岁(最小-最大:5-17岁)。入组时，12例患者有活动性疾病，其余24例为非活动性疾病。与不活跃患者相比，活跃jBD组NLR、PLR和MPV的平均值均显著升高(p= 0.026、p= 0.039和p= 0.07)。PLR是预测jBD患者疾病活动性的独立因素(p= 0.035, OR [95% Cl] = 0.988[0.978-0.999])。结论。本研究显示活动期jBD患者NLR和PLR值升高。其中，PLR可能是疾病活动性的危险预测因子。这些参数是容易获得的炎症标志物，可能有助于在早期发现活动性疾病，以预防并发症并指导治疗。
{"title":"Do Routine Laboratory Parameters Predict the Disease Activity in Children with Behçet’s Disease?","authors":"Deniz Gezgin, Sevcan A Yildirim¹, Bakkaloglu, Rutin Laboratuvar, Parametreleri Behçet, Hastalığı olan, Çocuklarda Hastalık, Aktivitesini Öngörüyor","doi":"10.12996/gmj.2023.76","DOIUrl":"https://doi.org/10.12996/gmj.2023.76","url":null,"abstract":"Objective. Juvenile Behçet’s disease (jBD) is a multi-systemic inflammatory disorder characterized by recurrent episodes of oral and genital aphthae, and cutaneous, gastrointestinal, neurological, articular, ocular and vascular manifestations. The main aim of this study was to assess the value of routine laboratory parameters for predicting disease activity in children with jBD. Methods. The demographic features and laboratory findings, including white blood cell, neutrophil (NEU), lymphocyte (LYM) and platelet (PLT) counts, neutrophil/ lymphocyte ratio (NLR), platelet/ lymphocyte ratio (PLR), mean platelet volume/platelet ratio (MPR) values were retrospectively evaluated between jBD patients with active and inactive, and compared with those in healthy peers. Inactive jBD was accepted as the absence of any clinical symptoms, while active jBD was accepted as presence of at least two clinical symptoms related with jBD. Results. Thirty six patients with jBD, and 58 sex-and age-matched healthy children were enrolled into this study. Median age at diagnosis of jBD was 13 (min – max: 5-17) years. 12 patients had active and remaining 24 inactive disease at enrollment. Active jBD group had significantly higher mean values for NLR, PLR, and lower MPV compared to inactive patients (p= 0.026, p= 0.039, and p= 0.07, respectively). PLR was revealed as an independent factor for predicting disease activity in jBD patients (p= 0.035, OR [95% Cl] = 0.988 [0.978-0.999]). Conclusion. This study has shown that active jBD patients had increased values of NLR and PLR. Among them PLR was the possible risk predictor for disease activity. These parameters are easily accessible inflammatory markers that may help detecting active disease in the early phase to prevent complications and to guide the therapy.","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45112304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
MD Oktay Ünsal, O. Yazıcı, N. Özdemir, Büşra Güvercin, A. Özet, Mehmet Ali Ergün
Objective: It is known that ATM heterozygosity is associated with increased risk of cancer, especially for breast cancer. This report reveals the characteristics of the patients with solid tumors other than breast cancer, associated with Germ-line ATM heterozygosity. Methods: Patients with germline ATM heterozygous mutation, admitted to the Department of Medical Genetics between January 2020 to 2023 were evaluated retrospectively. Patients with a diagnosis of solid tumors other than breast cancer, being followed up for at least 6 months were included in the study. Data of the patients were examinated using the SPSS software version 23. Results: Median aged at cancer diagnosis of 36 patients were 52.5 (23-65) years. The median follow-up period was 29.5 (11-283) months. Colorectal cancer was the most common diagnosis (30.6%). At follow-up, second primary solid malignancy was diagnosed in 27.8% (10 patients) of the patients. The median time for development of second primary malignancy were 9 (3-156) months. Most common diagnosis of these 10 patients were breast cancer (80%-8 patients). Conclusion: Development of various solid tumors other than breast cancer related to Germ-line ATM heterozygosity highlights the importance of ATM linked to cancer susceptibility.
{"title":"Solid Tumors other than Breast Cancer are Associated with Germ-line ATM Heterozygosity","authors":"MD Oktay Ünsal, O. Yazıcı, N. Özdemir, Büşra Güvercin, A. Özet, Mehmet Ali Ergün","doi":"10.12996/gmj.2023.87","DOIUrl":"https://doi.org/10.12996/gmj.2023.87","url":null,"abstract":"Objective: It is known that ATM heterozygosity is associated with increased risk of cancer, especially for breast cancer. This report reveals the characteristics of the patients with solid tumors other than breast cancer, associated with Germ-line ATM heterozygosity. Methods: Patients with germline ATM heterozygous mutation, admitted to the Department of Medical Genetics between January 2020 to 2023 were evaluated retrospectively. Patients with a diagnosis of solid tumors other than breast cancer, being followed up for at least 6 months were included in the study. Data of the patients were examinated using the SPSS software version 23. Results: Median aged at cancer diagnosis of 36 patients were 52.5 (23-65) years. The median follow-up period was 29.5 (11-283) months. Colorectal cancer was the most common diagnosis (30.6%). At follow-up, second primary solid malignancy was diagnosed in 27.8% (10 patients) of the patients. The median time for development of second primary malignancy were 9 (3-156) months. Most common diagnosis of these 10 patients were breast cancer (80%-8 patients). Conclusion: Development of various solid tumors other than breast cancer related to Germ-line ATM heterozygosity highlights the importance of ATM linked to cancer susceptibility.","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43925757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gelişimsel Kalça, Displazisinde Graf, Yönteminin Gözlemciler, Arası ve, Gözlemci İçi, Farklılıklarının Değerlendirilmesi, H. Doğruel, A. C. Baymurat, Ismail Cengiz Tuncay, Hakan Atalar
Purpose: The aim of this study was to evaluate possible differences in hip ultrasonography (US) results between physicians working in different medical centers. Method: In this study, a total of 117 horizontal US images representing all sonographic types of developmental dysplasia of the hip (DDH) were utilized. Four experienced researchers independently measured the 117 US images at different times. The results obtained by each researcher were documented separately, including alpha and beta angles, Graf types. All of the collected data were analyzed statistically to assess for interobserver and intraobserver variability. Results: The study found that the average change between the alpha angles ranged from a minimum of 1 to a maximum of 4. The mean change between the beta angles was wider, ranging from a minimum of 1.8 to a maximum of 8.2. To evaluate the differences between the Graf hip typologies, paired groups were formed and Cohen's Kappa method was used. For the first group k= 0.661, for the second group k= 0.671, for the third group K= 0.647, for the fourth group k= 0, 718, k= 0.717 for the fifth group and k= 0.637 for the sixth group. Interobserver Kappa evaluation results (k=0.647) showed moderate and significant agreement. Conclusion: The results revealed a moderate to substantial level of agreement between the researchers. Based on these findings, it was concluded that the use of US for screening and follow-up of the Graf hip typing method should be performed by experienced professionals.
{"title":"Evaluation of Interobserver and Intraobserver Differences of Graf Method in Developmental Hip Dysplasia","authors":"Gelişimsel Kalça, Displazisinde Graf, Yönteminin Gözlemciler, Arası ve, Gözlemci İçi, Farklılıklarının Değerlendirilmesi, H. Doğruel, A. C. Baymurat, Ismail Cengiz Tuncay, Hakan Atalar","doi":"10.12996/gmj.2023.86","DOIUrl":"https://doi.org/10.12996/gmj.2023.86","url":null,"abstract":"Purpose: The aim of this study was to evaluate possible differences in hip ultrasonography (US) results between physicians working in different medical centers. Method: In this study, a total of 117 horizontal US images representing all sonographic types of developmental dysplasia of the hip (DDH) were utilized. Four experienced researchers independently measured the 117 US images at different times. The results obtained by each researcher were documented separately, including alpha and beta angles, Graf types. All of the collected data were analyzed statistically to assess for interobserver and intraobserver variability. Results: The study found that the average change between the alpha angles ranged from a minimum of 1 to a maximum of 4. The mean change between the beta angles was wider, ranging from a minimum of 1.8 to a maximum of 8.2. To evaluate the differences between the Graf hip typologies, paired groups were formed and Cohen's Kappa method was used. For the first group k= 0.661, for the second group k= 0.671, for the third group K= 0.647, for the fourth group k= 0, 718, k= 0.717 for the fifth group and k= 0.637 for the sixth group. Interobserver Kappa evaluation results (k=0.647) showed moderate and significant agreement. Conclusion: The results revealed a moderate to substantial level of agreement between the researchers. Based on these findings, it was concluded that the use of US for screening and follow-up of the Graf hip typing method should be performed by experienced professionals.","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42356479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
MD Arzu Okur, Ozge Vural, Merve Yazol, Büşra Topuz Turkcan, A. Börcek, F. Pınarlı, C. Karadeniz
Purpose: The aim of this study is to investigate the clinical and radiological features, especially the importance of the T2-FLAIR mismatch sign and the response to treatment of patients diagnosed with diffuse midline gliomas (DMG) in our center. Methods: Eighteen patients treated with a diagnosis of DMG between January 2008 and January 2021 in Gazi University Medical Faculty, Department of Pediatric Oncology were retrospectively evaluated. The radiologycal evaluation was made as T2-FLAIR mismatch sign positive or negative. After a tumor board review, the diagnosis of DMG was made clinically and radiologically and all patients received local radiotherapy. Nimotuzumab was given as monotherapy or in combination with other medications Results: T2-FLAIR mismatch sign was positive for twelve patients and median OS for patients with T2-FLAIR mismatch positive and negative were 12.5 months and 9.2 months respectively (p=0.77). Median PFS for patients with T2-FLAIR mismatch sign positive and negative were 10.6 months and 4.8 months respectively (p=0.84). After nimotuzumab therapy, there was 4 cases with PR (44.4%), and 1 patient with SD (11.1%). Median OS for patients who were treated with and without nimotuzumab were 16.5 and 6.2 months respectively (p<0.05). Median PFS for patients who were treated with and without nimotuzumab were 13.3 and 3.7 months respectively (p<0.05). Conclusion: In conclusion, DMGs have poor prognosis. In our study patients with T2-FLAIR mismatch sign positive had better prognosis so it can be used as an imaging marker for prognosis. Nimotuzumab therapy may be a promising treatment option for DMG.
{"title":"Prognostic Factors for Survival in Pediatric Diffuse Midline Gliomas: The Importance of T2 FLAIR Missmatch Sign and Nimotuzumab Therapy","authors":"MD Arzu Okur, Ozge Vural, Merve Yazol, Büşra Topuz Turkcan, A. Börcek, F. Pınarlı, C. Karadeniz","doi":"10.12996/gmj.2023.84","DOIUrl":"https://doi.org/10.12996/gmj.2023.84","url":null,"abstract":"Purpose: The aim of this study is to investigate the clinical and radiological features, especially the importance of the T2-FLAIR mismatch sign and the response to treatment of patients diagnosed with diffuse midline gliomas (DMG) in our center. Methods: Eighteen patients treated with a diagnosis of DMG between January 2008 and January 2021 in Gazi University Medical Faculty, Department of Pediatric Oncology were retrospectively evaluated. The radiologycal evaluation was made as T2-FLAIR mismatch sign positive or negative. After a tumor board review, the diagnosis of DMG was made clinically and radiologically and all patients received local radiotherapy. Nimotuzumab was given as monotherapy or in combination with other medications Results: T2-FLAIR mismatch sign was positive for twelve patients and median OS for patients with T2-FLAIR mismatch positive and negative were 12.5 months and 9.2 months respectively (p=0.77). Median PFS for patients with T2-FLAIR mismatch sign positive and negative were 10.6 months and 4.8 months respectively (p=0.84). After nimotuzumab therapy, there was 4 cases with PR (44.4%), and 1 patient with SD (11.1%). Median OS for patients who were treated with and without nimotuzumab were 16.5 and 6.2 months respectively (p<0.05). Median PFS for patients who were treated with and without nimotuzumab were 13.3 and 3.7 months respectively (p<0.05). Conclusion: In conclusion, DMGs have poor prognosis. In our study patients with T2-FLAIR mismatch sign positive had better prognosis so it can be used as an imaging marker for prognosis. Nimotuzumab therapy may be a promising treatment option for DMG.","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45381334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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