Objective: COVID-19 related drugs and concomitantly used drugs of the patients for their co-morbid diseases may enhance the risk for having potential drug-drug interactions (pDDIs) during hospitalization. The aim of the present study was to identify the frequency and severity of pDDIs between the COVID-19 treatment options and concomitantly used drugs at COVID-19 inpatient clinics of a public hospital. Methods: A total of 321 files of the patients with COVID-19 who were hospitalized at inpatient clinics of a public hospital were assessed retrospectively. The frequency, risk category and severity of the pDDIs were assessed according to the Lexi-comp® online drug interaction database. Results: A vast majority of the patients (99.1%) had at least one pDDI with a maximum of 25 pDDIs. The most commonly detected pDDIs were between Favipiravir and Paracetamol (B risk category), (24.4%), followed by the pDDIs between Enoxaparin-Acetylsalicylic acid (D risk category), (10.1%) drug pairs. Hyper-polypharmacy (≥10 drugs) was significantly and positively associated with male gender (p=0.023), adult age group (p=0.002) and co-morbid diabetes mellitus (p<0.001) and essential hypertension (p<0.001). The presence of moderate to major pDDIs was significantly and positively associated with male gender (p=0.012) and adult age group (p=0.019). Conclusion: The present study revealed that the frequency of pDDIs among hospitalized patients with COVID-19 are quite high. Although the severity of pDDIs at COVID-19 inpatient clinics in general, are moderate and preventable, physicians should pay a particular attention regarding the pDDIs which may have life-threatening consequences such as the risk of bleeding.
{"title":"Evaluation of the Potential Drug-Drug Interactions among Hospitalized Patients with COVID-19: A Cross-Sectional Study","authors":"E. Özdamar, Berrak Şahtiyancı","doi":"10.12996/gmj.2023.61","DOIUrl":"https://doi.org/10.12996/gmj.2023.61","url":null,"abstract":"Objective: COVID-19 related drugs and concomitantly used drugs of the patients for their co-morbid diseases may enhance the risk for having potential drug-drug interactions (pDDIs) during hospitalization. The aim of the present study was to identify the frequency and severity of pDDIs between the COVID-19 treatment options and concomitantly used drugs at COVID-19 inpatient clinics of a public hospital. Methods: A total of 321 files of the patients with COVID-19 who were hospitalized at inpatient clinics of a public hospital were assessed retrospectively. The frequency, risk category and severity of the pDDIs were assessed according to the Lexi-comp® online drug interaction database. Results: A vast majority of the patients (99.1%) had at least one pDDI with a maximum of 25 pDDIs. The most commonly detected pDDIs were between Favipiravir and Paracetamol (B risk category), (24.4%), followed by the pDDIs between Enoxaparin-Acetylsalicylic acid (D risk category), (10.1%) drug pairs. Hyper-polypharmacy (≥10 drugs) was significantly and positively associated with male gender (p=0.023), adult age group (p=0.002) and co-morbid diabetes mellitus (p<0.001) and essential hypertension (p<0.001). The presence of moderate to major pDDIs was significantly and positively associated with male gender (p=0.012) and adult age group (p=0.019). Conclusion: The present study revealed that the frequency of pDDIs among hospitalized patients with COVID-19 are quite high. Although the severity of pDDIs at COVID-19 inpatient clinics in general, are moderate and preventable, physicians should pay a particular attention regarding the pDDIs which may have life-threatening consequences such as the risk of bleeding.","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42204947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Peritumoral and Intratumoral Lymphocytic Infiltration and Stromal Reaction in High-Risk Endometrioid Carcinomas","authors":"","doi":"10.12996/gmj.2023.31","DOIUrl":"https://doi.org/10.12996/gmj.2023.31","url":null,"abstract":"","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41909653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Investigation of Inflammatory Effects of Morphine and Fentanyl on Early Wound Healing in Rats: an Experimental Study","authors":"","doi":"10.12996/gmj.2023.35","DOIUrl":"https://doi.org/10.12996/gmj.2023.35","url":null,"abstract":"","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48432260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Endometriosis and Migraine","authors":"","doi":"10.12996/gmj.2023.54","DOIUrl":"https://doi.org/10.12996/gmj.2023.54","url":null,"abstract":"","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47478103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Everolimus Pretreatment Protects the Lung From Ischemia-Reperfusion Injury","authors":"","doi":"10.12996/gmj.2023.33","DOIUrl":"https://doi.org/10.12996/gmj.2023.33","url":null,"abstract":"","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42242670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Short and Intermittent Course of Oral Contraceptive Pills and Risk of Cerebral Venous Thrombosis","authors":"","doi":"10.12996/gmj.2023.51","DOIUrl":"https://doi.org/10.12996/gmj.2023.51","url":null,"abstract":"","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43303731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Huge Rhinolith in a Moderate to Severe Persistent Allergic Rhinitis Patient: A Rare Presentation","authors":"","doi":"10.12996/gmj.2023.44","DOIUrl":"https://doi.org/10.12996/gmj.2023.44","url":null,"abstract":"","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45755092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Analyzing Exercises Types for Cancer Patients","authors":"","doi":"10.12996/gmj.2023.53","DOIUrl":"https://doi.org/10.12996/gmj.2023.53","url":null,"abstract":"","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48396152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Knowledge and Attitude Towards Genetic Testing Among Public Selected Setting in Ethiope East Local Government Area (LGA)","authors":"","doi":"10.12996/gmj.2023.30","DOIUrl":"https://doi.org/10.12996/gmj.2023.30","url":null,"abstract":"","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46152224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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