S. Sanaie, Behnam Sadigi, Reza Yarani, Nikolaj Travica, Zahra Yousefi, S. Shakouri, Alireza Ostadrahimi, M. Mobasseri, Fateme Tahmasbi, Mostafa Araj-khodaei
Aim: Diabetes mellitus is a chronic medical condition characterized by an accumulation of glucose in the bloodstream. Specifically, type 2 diabetes occurs when the body’s cells are unable to efficiently respond to insulin, the hormone responsible for transporting circulatory glucose into cells. In the advanced stages of the disease, the body may also not produce sufficient amounts of insulin. As the disease progresses, the symptoms become more severe and potentially lead to a series of comorbidities. Although several medications are used to treat and control type 2 diabetes, these medications may have serious side effects. Hence, the use of herbal medicine to alleviate type 2 diabetes has been studied and has attracted widespread interest. Our major goal is to examine these herbs' effectiveness and related mechanisms of action in treating type 2 diabetes. Method : We studied worldwide traditional medicines, old texts, and published literature for anti-diabetic effect of Melissa officinalis and saffron. Electronic databases comprising PubMed, Web of Science, Science Direct, Scopus and Google Scholar were searched to collect articles published between 1990 and 2022 years. Results : We confirmed that a variety of herbal therapies, including saffron and lemon balm (Melissa officinalis), had anti-diabetic activities based on the findings of various research. Conclusion: Saffron and Melissa officinalis have anti-diabetic properties.
目的：糖尿病是一种以血液中葡萄糖积聚为特征的慢性疾病。具体来说，当身体细胞无法有效地对胰岛素做出反应时，就会发生2型糖尿病，胰岛素是负责将循环葡萄糖输送到细胞中的激素。在疾病的晚期，身体也可能无法产生足够量的胰岛素。随着疾病的发展，症状变得更加严重，并可能导致一系列合并症。尽管有几种药物用于治疗和控制2型糖尿病，但这些药物可能会产生严重的副作用。因此，使用草药来缓解2型糖尿病已经得到了研究，并引起了广泛的兴趣。我们的主要目标是检查这些草药在治疗2型糖尿病方面的有效性和相关作用机制。方法：我们研究了世界各地的传统药物、旧文献和已发表的文献中关于梅丽莎·officinalis和藏红花抗糖尿病的作用。搜索包括PubMed、Web of Science、Science Direct、Scopus和Google Scholar在内的电子数据库，以收集1990年至2022年间发表的文章。结果：根据各种研究结果，我们证实了包括藏红花和柠檬风油精（Melissa officinalis）在内的多种草药疗法具有抗糖尿病活性。结论：藏红花和梅丽莎具有抗糖尿病作用。
{"title":"Anti-diabetic Properties of Melissa officinalis and Saffron: Recent Advances and Discoveries","authors":"S. Sanaie, Behnam Sadigi, Reza Yarani, Nikolaj Travica, Zahra Yousefi, S. Shakouri, Alireza Ostadrahimi, M. Mobasseri, Fateme Tahmasbi, Mostafa Araj-khodaei","doi":"10.12996/gmj.2023.93","DOIUrl":"https://doi.org/10.12996/gmj.2023.93","url":null,"abstract":"Aim: Diabetes mellitus is a chronic medical condition characterized by an accumulation of glucose in the bloodstream. Specifically, type 2 diabetes occurs when the body’s cells are unable to efficiently respond to insulin, the hormone responsible for transporting circulatory glucose into cells. In the advanced stages of the disease, the body may also not produce sufficient amounts of insulin. As the disease progresses, the symptoms become more severe and potentially lead to a series of comorbidities. Although several medications are used to treat and control type 2 diabetes, these medications may have serious side effects. Hence, the use of herbal medicine to alleviate type 2 diabetes has been studied and has attracted widespread interest. Our major goal is to examine these herbs' effectiveness and related mechanisms of action in treating type 2 diabetes. Method : We studied worldwide traditional medicines, old texts, and published literature for anti-diabetic effect of Melissa officinalis and saffron. Electronic databases comprising PubMed, Web of Science, Science Direct, Scopus and Google Scholar were searched to collect articles published between 1990 and 2022 years. Results : We confirmed that a variety of herbal therapies, including saffron and lemon balm (Melissa officinalis), had anti-diabetic activities based on the findings of various research. Conclusion: Saffron and Melissa officinalis have anti-diabetic properties.","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47195144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gelişimsel Kalça, Displazisinde Graf, Yönteminin Gözlemciler, Arası ve, Gözlemci İçi, Farklılıklarının Değerlendirilmesi, H. Doğruel, A. C. Baymurat, Ismail Cengiz Tuncay, Hakan Atalar
Purpose: The aim of this study was to evaluate possible differences in hip ultrasonography (US) results between physicians working in different medical centers. Method: In this study, a total of 117 horizontal US images representing all sonographic types of developmental dysplasia of the hip (DDH) were utilized. Four experienced researchers independently measured the 117 US images at different times. The results obtained by each researcher were documented separately, including alpha and beta angles, Graf types. All of the collected data were analyzed statistically to assess for interobserver and intraobserver variability. Results: The study found that the average change between the alpha angles ranged from a minimum of 1 to a maximum of 4. The mean change between the beta angles was wider, ranging from a minimum of 1.8 to a maximum of 8.2. To evaluate the differences between the Graf hip typologies, paired groups were formed and Cohen's Kappa method was used. For the first group k= 0.661, for the second group k= 0.671, for the third group K= 0.647, for the fourth group k= 0, 718, k= 0.717 for the fifth group and k= 0.637 for the sixth group. Interobserver Kappa evaluation results (k=0.647) showed moderate and significant agreement. Conclusion: The results revealed a moderate to substantial level of agreement between the researchers. Based on these findings, it was concluded that the use of US for screening and follow-up of the Graf hip typing method should be performed by experienced professionals.
{"title":"Evaluation of Interobserver and Intraobserver Differences of Graf Method in Developmental Hip Dysplasia","authors":"Gelişimsel Kalça, Displazisinde Graf, Yönteminin Gözlemciler, Arası ve, Gözlemci İçi, Farklılıklarının Değerlendirilmesi, H. Doğruel, A. C. Baymurat, Ismail Cengiz Tuncay, Hakan Atalar","doi":"10.12996/gmj.2023.86","DOIUrl":"https://doi.org/10.12996/gmj.2023.86","url":null,"abstract":"Purpose: The aim of this study was to evaluate possible differences in hip ultrasonography (US) results between physicians working in different medical centers. Method: In this study, a total of 117 horizontal US images representing all sonographic types of developmental dysplasia of the hip (DDH) were utilized. Four experienced researchers independently measured the 117 US images at different times. The results obtained by each researcher were documented separately, including alpha and beta angles, Graf types. All of the collected data were analyzed statistically to assess for interobserver and intraobserver variability. Results: The study found that the average change between the alpha angles ranged from a minimum of 1 to a maximum of 4. The mean change between the beta angles was wider, ranging from a minimum of 1.8 to a maximum of 8.2. To evaluate the differences between the Graf hip typologies, paired groups were formed and Cohen's Kappa method was used. For the first group k= 0.661, for the second group k= 0.671, for the third group K= 0.647, for the fourth group k= 0, 718, k= 0.717 for the fifth group and k= 0.637 for the sixth group. Interobserver Kappa evaluation results (k=0.647) showed moderate and significant agreement. Conclusion: The results revealed a moderate to substantial level of agreement between the researchers. Based on these findings, it was concluded that the use of US for screening and follow-up of the Graf hip typing method should be performed by experienced professionals.","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42356479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Deniz Gezgin, Sevcan A Yildirim¹, Bakkaloglu, Rutin Laboratuvar, Parametreleri Behçet, Hastalığı olan, Çocuklarda Hastalık, Aktivitesini Öngörüyor
Objective. Juvenile Behçet’s disease (jBD) is a multi-systemic inflammatory disorder characterized by recurrent episodes of oral and genital aphthae, and cutaneous, gastrointestinal, neurological, articular, ocular and vascular manifestations. The main aim of this study was to assess the value of routine laboratory parameters for predicting disease activity in children with jBD. Methods. The demographic features and laboratory findings, including white blood cell, neutrophil (NEU), lymphocyte (LYM) and platelet (PLT) counts, neutrophil/ lymphocyte ratio (NLR), platelet/ lymphocyte ratio (PLR), mean platelet volume/platelet ratio (MPR) values were retrospectively evaluated between jBD patients with active and inactive, and compared with those in healthy peers. Inactive jBD was accepted as the absence of any clinical symptoms, while active jBD was accepted as presence of at least two clinical symptoms related with jBD. Results. Thirty six patients with jBD, and 58 sex-and age-matched healthy children were enrolled into this study. Median age at diagnosis of jBD was 13 (min – max: 5-17) years. 12 patients had active and remaining 24 inactive disease at enrollment. Active jBD group had significantly higher mean values for NLR, PLR, and lower MPV compared to inactive patients (p= 0.026, p= 0.039, and p= 0.07, respectively). PLR was revealed as an independent factor for predicting disease activity in jBD patients (p= 0.035, OR [95% Cl] = 0.988 [0.978-0.999]). Conclusion. This study has shown that active jBD patients had increased values of NLR and PLR. Among them PLR was the possible risk predictor for disease activity. These parameters are easily accessible inflammatory markers that may help detecting active disease in the early phase to prevent complications and to guide the therapy.
目标。青少年behet病(jBD)是一种多系统炎症性疾病，其特征是口腔和生殖器溃疡的反复发作，以及皮肤、胃肠、神经、关节、眼部和血管的表现。本研究的主要目的是评估常规实验室参数对预测jBD患儿疾病活动性的价值。方法。回顾性评价活动性和非活动性jBD患者的人口统计学特征和实验室检查结果，包括白细胞、中性粒细胞(NEU)、淋巴细胞(LYM)和血小板(PLT)计数、中性粒细胞/淋巴细胞比率(NLR)、血小板/淋巴细胞比率(PLR)、平均血小板体积/血小板比率(MPR)值，并与健康同龄人进行比较。非活动性jBD被接受为没有任何临床症状，而活动性jBD被接受为存在至少两种与jBD相关的临床症状。结果。36名jBD患者和58名性别和年龄匹配的健康儿童参加了这项研究。诊断为jBD的中位年龄为13岁(最小-最大:5-17岁)。入组时，12例患者有活动性疾病，其余24例为非活动性疾病。与不活跃患者相比，活跃jBD组NLR、PLR和MPV的平均值均显著升高(p= 0.026、p= 0.039和p= 0.07)。PLR是预测jBD患者疾病活动性的独立因素(p= 0.035, OR [95% Cl] = 0.988[0.978-0.999])。结论。本研究显示活动期jBD患者NLR和PLR值升高。其中，PLR可能是疾病活动性的危险预测因子。这些参数是容易获得的炎症标志物，可能有助于在早期发现活动性疾病，以预防并发症并指导治疗。
{"title":"Do Routine Laboratory Parameters Predict the Disease Activity in Children with Behçet’s Disease?","authors":"Deniz Gezgin, Sevcan A Yildirim¹, Bakkaloglu, Rutin Laboratuvar, Parametreleri Behçet, Hastalığı olan, Çocuklarda Hastalık, Aktivitesini Öngörüyor","doi":"10.12996/gmj.2023.76","DOIUrl":"https://doi.org/10.12996/gmj.2023.76","url":null,"abstract":"Objective. Juvenile Behçet’s disease (jBD) is a multi-systemic inflammatory disorder characterized by recurrent episodes of oral and genital aphthae, and cutaneous, gastrointestinal, neurological, articular, ocular and vascular manifestations. The main aim of this study was to assess the value of routine laboratory parameters for predicting disease activity in children with jBD. Methods. The demographic features and laboratory findings, including white blood cell, neutrophil (NEU), lymphocyte (LYM) and platelet (PLT) counts, neutrophil/ lymphocyte ratio (NLR), platelet/ lymphocyte ratio (PLR), mean platelet volume/platelet ratio (MPR) values were retrospectively evaluated between jBD patients with active and inactive, and compared with those in healthy peers. Inactive jBD was accepted as the absence of any clinical symptoms, while active jBD was accepted as presence of at least two clinical symptoms related with jBD. Results. Thirty six patients with jBD, and 58 sex-and age-matched healthy children were enrolled into this study. Median age at diagnosis of jBD was 13 (min – max: 5-17) years. 12 patients had active and remaining 24 inactive disease at enrollment. Active jBD group had significantly higher mean values for NLR, PLR, and lower MPV compared to inactive patients (p= 0.026, p= 0.039, and p= 0.07, respectively). PLR was revealed as an independent factor for predicting disease activity in jBD patients (p= 0.035, OR [95% Cl] = 0.988 [0.978-0.999]). Conclusion. This study has shown that active jBD patients had increased values of NLR and PLR. Among them PLR was the possible risk predictor for disease activity. These parameters are easily accessible inflammatory markers that may help detecting active disease in the early phase to prevent complications and to guide the therapy.","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45112304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
MD Oktay Ünsal, O. Yazıcı, N. Özdemir, Büşra Güvercin, A. Özet, Mehmet Ali Ergün
Objective: It is known that ATM heterozygosity is associated with increased risk of cancer, especially for breast cancer. This report reveals the characteristics of the patients with solid tumors other than breast cancer, associated with Germ-line ATM heterozygosity. Methods: Patients with germline ATM heterozygous mutation, admitted to the Department of Medical Genetics between January 2020 to 2023 were evaluated retrospectively. Patients with a diagnosis of solid tumors other than breast cancer, being followed up for at least 6 months were included in the study. Data of the patients were examinated using the SPSS software version 23. Results: Median aged at cancer diagnosis of 36 patients were 52.5 (23-65) years. The median follow-up period was 29.5 (11-283) months. Colorectal cancer was the most common diagnosis (30.6%). At follow-up, second primary solid malignancy was diagnosed in 27.8% (10 patients) of the patients. The median time for development of second primary malignancy were 9 (3-156) months. Most common diagnosis of these 10 patients were breast cancer (80%-8 patients). Conclusion: Development of various solid tumors other than breast cancer related to Germ-line ATM heterozygosity highlights the importance of ATM linked to cancer susceptibility.
{"title":"Solid Tumors other than Breast Cancer are Associated with Germ-line ATM Heterozygosity","authors":"MD Oktay Ünsal, O. Yazıcı, N. Özdemir, Büşra Güvercin, A. Özet, Mehmet Ali Ergün","doi":"10.12996/gmj.2023.87","DOIUrl":"https://doi.org/10.12996/gmj.2023.87","url":null,"abstract":"Objective: It is known that ATM heterozygosity is associated with increased risk of cancer, especially for breast cancer. This report reveals the characteristics of the patients with solid tumors other than breast cancer, associated with Germ-line ATM heterozygosity. Methods: Patients with germline ATM heterozygous mutation, admitted to the Department of Medical Genetics between January 2020 to 2023 were evaluated retrospectively. Patients with a diagnosis of solid tumors other than breast cancer, being followed up for at least 6 months were included in the study. Data of the patients were examinated using the SPSS software version 23. Results: Median aged at cancer diagnosis of 36 patients were 52.5 (23-65) years. The median follow-up period was 29.5 (11-283) months. Colorectal cancer was the most common diagnosis (30.6%). At follow-up, second primary solid malignancy was diagnosed in 27.8% (10 patients) of the patients. The median time for development of second primary malignancy were 9 (3-156) months. Most common diagnosis of these 10 patients were breast cancer (80%-8 patients). Conclusion: Development of various solid tumors other than breast cancer related to Germ-line ATM heterozygosity highlights the importance of ATM linked to cancer susceptibility.","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43925757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
MD Arzu Okur, Ozge Vural, Merve Yazol, Büşra Topuz Turkcan, A. Börcek, F. Pınarlı, C. Karadeniz
Purpose: The aim of this study is to investigate the clinical and radiological features, especially the importance of the T2-FLAIR mismatch sign and the response to treatment of patients diagnosed with diffuse midline gliomas (DMG) in our center. Methods: Eighteen patients treated with a diagnosis of DMG between January 2008 and January 2021 in Gazi University Medical Faculty, Department of Pediatric Oncology were retrospectively evaluated. The radiologycal evaluation was made as T2-FLAIR mismatch sign positive or negative. After a tumor board review, the diagnosis of DMG was made clinically and radiologically and all patients received local radiotherapy. Nimotuzumab was given as monotherapy or in combination with other medications Results: T2-FLAIR mismatch sign was positive for twelve patients and median OS for patients with T2-FLAIR mismatch positive and negative were 12.5 months and 9.2 months respectively (p=0.77). Median PFS for patients with T2-FLAIR mismatch sign positive and negative were 10.6 months and 4.8 months respectively (p=0.84). After nimotuzumab therapy, there was 4 cases with PR (44.4%), and 1 patient with SD (11.1%). Median OS for patients who were treated with and without nimotuzumab were 16.5 and 6.2 months respectively (p<0.05). Median PFS for patients who were treated with and without nimotuzumab were 13.3 and 3.7 months respectively (p<0.05). Conclusion: In conclusion, DMGs have poor prognosis. In our study patients with T2-FLAIR mismatch sign positive had better prognosis so it can be used as an imaging marker for prognosis. Nimotuzumab therapy may be a promising treatment option for DMG.
{"title":"Prognostic Factors for Survival in Pediatric Diffuse Midline Gliomas: The Importance of T2 FLAIR Missmatch Sign and Nimotuzumab Therapy","authors":"MD Arzu Okur, Ozge Vural, Merve Yazol, Büşra Topuz Turkcan, A. Börcek, F. Pınarlı, C. Karadeniz","doi":"10.12996/gmj.2023.84","DOIUrl":"https://doi.org/10.12996/gmj.2023.84","url":null,"abstract":"Purpose: The aim of this study is to investigate the clinical and radiological features, especially the importance of the T2-FLAIR mismatch sign and the response to treatment of patients diagnosed with diffuse midline gliomas (DMG) in our center. Methods: Eighteen patients treated with a diagnosis of DMG between January 2008 and January 2021 in Gazi University Medical Faculty, Department of Pediatric Oncology were retrospectively evaluated. The radiologycal evaluation was made as T2-FLAIR mismatch sign positive or negative. After a tumor board review, the diagnosis of DMG was made clinically and radiologically and all patients received local radiotherapy. Nimotuzumab was given as monotherapy or in combination with other medications Results: T2-FLAIR mismatch sign was positive for twelve patients and median OS for patients with T2-FLAIR mismatch positive and negative were 12.5 months and 9.2 months respectively (p=0.77). Median PFS for patients with T2-FLAIR mismatch sign positive and negative were 10.6 months and 4.8 months respectively (p=0.84). After nimotuzumab therapy, there was 4 cases with PR (44.4%), and 1 patient with SD (11.1%). Median OS for patients who were treated with and without nimotuzumab were 16.5 and 6.2 months respectively (p<0.05). Median PFS for patients who were treated with and without nimotuzumab were 13.3 and 3.7 months respectively (p<0.05). Conclusion: In conclusion, DMGs have poor prognosis. In our study patients with T2-FLAIR mismatch sign positive had better prognosis so it can be used as an imaging marker for prognosis. Nimotuzumab therapy may be a promising treatment option for DMG.","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45381334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bao Ling Wong, P. S. Heng, Chian Ling Tang, Nik Fariza Husna Nik Hassan
Background: Amyloidosis is defined as a group of diseases which resulted from abnormal extracellular deposition of insoluble protein, called amyloid. It can either presented as localized or with systemic involvement. Laryngeal amyloidosis is a very rare cause of dysphonia, accounting for only 0.2 to 1.2 percent of all benign laryngeal tumours. Objectives: To highlight the clinical presentations and raise awareness of laryngeal amyloidosis among otorhinolaryngology surgeons. An index of suspicion must be conveyed to the histopathologist in the request form for them to embark on a specific staining technique. Method: We discussed two cases of laryngeal amyloidosis, with their presentations, management and the follow up. Both cases were middle aged female. The diagnosis of laryngeal amyloidosis is only by histopathological as clinically it is very ambiguous. Conclusion: The mainstay of treatment for laryngeal amyloidosis is surgical debulking but it is not curative as complete removal of the diseased tissue is difficult. In addition, the treatment should be directed towards the maintenance of the airway and the improvement of the voice.
{"title":"Laryngeal Amyloidosis Case Series: Rare Cause of Hoarseness","authors":"Bao Ling Wong, P. S. Heng, Chian Ling Tang, Nik Fariza Husna Nik Hassan","doi":"10.12996/gmj.2023.72","DOIUrl":"https://doi.org/10.12996/gmj.2023.72","url":null,"abstract":"Background: Amyloidosis is defined as a group of diseases which resulted from abnormal extracellular deposition of insoluble protein, called amyloid. It can either presented as localized or with systemic involvement. Laryngeal amyloidosis is a very rare cause of dysphonia, accounting for only 0.2 to 1.2 percent of all benign laryngeal tumours. Objectives: To highlight the clinical presentations and raise awareness of laryngeal amyloidosis among otorhinolaryngology surgeons. An index of suspicion must be conveyed to the histopathologist in the request form for them to embark on a specific staining technique. Method: We discussed two cases of laryngeal amyloidosis, with their presentations, management and the follow up. Both cases were middle aged female. The diagnosis of laryngeal amyloidosis is only by histopathological as clinically it is very ambiguous. Conclusion: The mainstay of treatment for laryngeal amyloidosis is surgical debulking but it is not curative as complete removal of the diseased tissue is difficult. In addition, the treatment should be directed towards the maintenance of the airway and the improvement of the voice.","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45206189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Managing a Ruptured Giant Abdominal Aortic Aneurysm with Aortocaval Fistula","authors":"","doi":"10.12996/gmj.2023.74","DOIUrl":"https://doi.org/10.12996/gmj.2023.74","url":null,"abstract":"","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48688294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Effects of Cerium Oxide on Sevoflurane Anesthesia and its Relationship to Renal Injury in Rats","authors":"","doi":"10.12996/gmj.2023.59","DOIUrl":"https://doi.org/10.12996/gmj.2023.59","url":null,"abstract":"","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45974936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Physiological changes are seen in many systems in the body related to aging. Treatment modalities and drug prescribing processes need to be re-evaluated in the geriatric population. To elaborate on polypharmacy, the number of drugs the individual should use must also be defined effectively. Various criteria have been developed for prescribing and using drugs for elderly individuals. The most used of these criteria is called the Beers criteria. STOPP and START criteria are other criteria used. Material and Method: Our study aimed to retrospectively evaluate the prevalence of inappropriate drug use in patients aged 65 and over who were hospitalized in the Internal Medicine and Neurology Intensive Care Units of Ankara Atatürk Training and Research Hospital in terms of STOPP-START criteria. Results: Study group consists of 168 (58,3%) female and 120 (41,7%) male. A total of 727 diseases were diagnosed in 288 patients. 201 of these were "Cerebrovascular Diseases,” 153 were "Hypertension.” While the most common STOPP criterion main group and single criterion were antiplatelet anticoagulant agent group (35,7%), “Presence of a drug class causing duplication (Aiming optimum level with a single drug before adding a new agent) (23,2%)”, respectively. At the same time, the most common START criterion main group and single criterion were cardiovascular system group (94,5%), and “Statin therapy in patients who are near the end of life or who are not older than 85 years of age, with a history of coronary, cerebral or peripheral vascular disease”, respectively (70,2%). Conclusion: It is seen that the study results are generally similar to the national literature. There are partisan differences between the study results and the international literature. It is anticipated that these differences can be attributed to the diagnostic criteria used, study group selection, and study design differences.
{"title":"The Evaluation of the Prevalence of Improper Medication Use in Patients Age of 65 and over in Internal Diseases and Neurology Intensive Care Units in Terms of Stopp-Start Criteria","authors":"Özdağ Erdil, H. Z. Güney","doi":"10.12996/gmj.2023.62","DOIUrl":"https://doi.org/10.12996/gmj.2023.62","url":null,"abstract":"Introduction: Physiological changes are seen in many systems in the body related to aging. Treatment modalities and drug prescribing processes need to be re-evaluated in the geriatric population. To elaborate on polypharmacy, the number of drugs the individual should use must also be defined effectively. Various criteria have been developed for prescribing and using drugs for elderly individuals. The most used of these criteria is called the Beers criteria. STOPP and START criteria are other criteria used. Material and Method: Our study aimed to retrospectively evaluate the prevalence of inappropriate drug use in patients aged 65 and over who were hospitalized in the Internal Medicine and Neurology Intensive Care Units of Ankara Atatürk Training and Research Hospital in terms of STOPP-START criteria. Results: Study group consists of 168 (58,3%) female and 120 (41,7%) male. A total of 727 diseases were diagnosed in 288 patients. 201 of these were \"Cerebrovascular Diseases,” 153 were \"Hypertension.” While the most common STOPP criterion main group and single criterion were antiplatelet anticoagulant agent group (35,7%), “Presence of a drug class causing duplication (Aiming optimum level with a single drug before adding a new agent) (23,2%)”, respectively. At the same time, the most common START criterion main group and single criterion were cardiovascular system group (94,5%), and “Statin therapy in patients who are near the end of life or who are not older than 85 years of age, with a history of coronary, cerebral or peripheral vascular disease”, respectively (70,2%). Conclusion: It is seen that the study results are generally similar to the national literature. There are partisan differences between the study results and the international literature. It is anticipated that these differences can be attributed to the diagnostic criteria used, study group selection, and study design differences.","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46011422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Microsatellite Instability in Lung Adenocarcinoma","authors":"","doi":"10.12996/gmj.2023.70","DOIUrl":"https://doi.org/10.12996/gmj.2023.70","url":null,"abstract":"","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45189956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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