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Investigating the relationship between ultrasound measured optic nerve sheath diameter and preeclampsia 探讨超声测量视神经鞘直径与子痫前期的关系
IF 0.7 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2019-08-01 DOI: 10.3934/medsci.2019.3.250
S. arzpeyma, Pooya Bahari Khorram, M. Asgharnia, Z. Mohtasham-Amiri
Background: Increased intracranial pressure (ICP) is one of the main consequences of preeclampsia, which could be manifested by a change in the optic nerve sheath diameter as a radiologic and clinical sign. However, the effect of preeclampsia on the ultrasound measured optic nerve sheath diameter (ONSD) and its possible applications are rarely investigated. The aim of this study was to determine the relationship between ultrasound measured optic nerve sheath diameter and the risk of preeclampsia. Methods: This case-control study was performed on 38 pregnant women with normal blood pressure and 38 pregnant women with preeclampsia in Alzahra hospital in Rasht during 2018. A checklist was used to record demographic and clinical data. Measurements were made using a high resolution transducer, by placing the focal point and a cursor line at 3 mm behind the globe, perpendicular to the optic nerve axis (measuring the mean of two eyes). Data were analyzed by SPSS software version 21. Results: The mean age of patients with preeclampsia and normal pregnant women were 31.42 ± 6.2 years and 29.76 ± 3.46 years, respectively. Differences in gravidity (P = 0.854) and the history of hypertension (P = 0.946) in both groups were not statistically significant (P < 0.05). The mean optic nerve sheath diameter in women with preeclampsia was significantly higher than pregnant women with normal blood pressure (P = 0.001). The area under the ROC curve for the ONSD was 0.82 and the cut-off point for this index was calculated as 4.55 mm, which at this point, sensitivity and specificity were 78.9% and 73.7%, respectively. Conclusion: There was a relationship between the risk of preeclampsia and ONSD, in the way that the ONSD in preeclampsia patients was higher than that of normal subjects. However, the mean ONSD in two groups of mild and severe preeclampsia were not significantly different.
背景:颅内压升高(ICP)是子痫前期的主要后果之一,它可以通过视神经鞘直径的改变作为影像学和临床体征表现出来。然而,子痫前期对超声测量视神经鞘直径(ONSD)的影响及其可能的应用研究很少。本研究的目的是确定超声测量视神经鞘直径与子痫前期风险之间的关系。方法:对2018年拉什特市Alzahra医院38例血压正常孕妇和38例先兆子痫孕妇进行病例对照研究。使用核对表记录人口统计和临床数据。测量使用高分辨率传感器,通过将焦点和光标线放置在球体后3毫米处,垂直于视神经轴(测量两只眼睛的平均值)。数据采用SPSS软件21版进行分析。结果:子痫前期患者和正常孕妇的平均年龄分别为31.42±6.2岁和29.76±3.46岁。两组患者的妊娠程度(P = 0.854)、高血压史(P = 0.946)差异均无统计学意义(P < 0.05)。子痫前期女性视神经鞘平均直径明显高于血压正常的孕妇(P = 0.001)。ONSD的ROC曲线下面积为0.82,计算该指标的分界点为4.55 mm,此时的敏感性和特异性分别为78.9%和73.7%。结论:子痫前期患者的ONSD高于正常人群,存在子痫前期风险与ONSD之间的关系。但两组轻、重度子痫前期患者的平均ONSD差异无统计学意义。
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引用次数: 5
Improvement in montreal cognitive assessment score following three-week pain rehabilitation program 三周疼痛康复计划后蒙特利尔认知评估评分的改善
IF 0.7 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2019-07-26 DOI: 10.3934/MEDSCI.2019.3.201
Joann E. Bolton, Elke R. Lacayo, S. Kurklinsky, C. Sletten
Aim: To demonstrate improvement in cognitive function following a 3-week Intensive Interdisciplinary Pain Rehabilitation Program. Methods: The Montreal Cognitive Assessment (MoCA) was performed at initial evaluation and on dismissal day of the program. Results: The patient had chronic, non-cancer lower back pain for over 15 years for which patient had myriad of treatments. Patient was directed to Intensive Interdisciplinary Pain Rehabilitation Program as a last resort treatment. The patient had moderate cognitive impairment when he joined the program (MoCA score of 17/30) that dramatically improved into the normal cognitive range by the end of the program (MoCA score of 26/30). Conclusions: Improvement in MoCA score was demonstrated after completion of the Intensive Interdisciplinary Pain Rehabilitation Program, which is the first demonstrated case.
目的:证明三周强化跨学科疼痛康复计划后认知功能的改善。方法:采用蒙特利尔认知能力评估(MoCA),在项目初评估和结束当天进行。结果:患者患有慢性非癌性腰痛超过15年,患者接受过无数次治疗。患者被引导到强化跨学科疼痛康复计划作为最后的治疗手段。患者加入项目时有中度认知障碍(MoCA评分为17/30),在项目结束时显著改善到正常认知范围(MoCA评分为26/30)。结论:完成强化跨学科疼痛康复计划后,MoCA评分得到改善,这是第一个被证实的病例。
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引用次数: 0
Immunotherapy for synovial sarcoma 滑膜肉瘤的免疫治疗
IF 0.7 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2019-07-14 DOI: 10.3934/MEDSCI.2019.3.191
C. Albert, S. Pollack
Synovial sarcoma (SS) is a relatively common subtype of soft tissue sarcoma that typically affects young adults. Nearly all tumors harbor a translocation between SS18 and SSX1/SSX2 and the vast majority express the cancer testis antigen (CTA) NY-ESO-1. While patients with small, non-metastatic tumors are often cured surgically, outcomes remain poor for patients with locally advanced or metastatic disease, even when aggressive chemotherapy and radiotherapy are employed. Therefore, innovative systemic therapies that target the biology of the disease are needed to improve outcomes for these higher risk patients. One such category is tumor-directed immune therapies. In this review, we will discuss the current status of immunotherapy for SS, including the recent trial results, ongoing challenges, and future directions.
滑膜肉瘤(SS)是一种相对常见的软组织肉瘤亚型,通常影响年轻人。几乎所有肿瘤都存在SS18和SSX1/SSX2之间的易位,并且绝大多数表达癌睾丸抗原(CTA) NY-ESO-1。虽然小而非转移性肿瘤的患者通常通过手术治愈,但对于局部晚期或转移性疾病的患者,即使采用积极的化疗和放疗,结果仍然很差。因此,需要针对疾病生物学的创新系统疗法来改善这些高风险患者的预后。其中一类是肿瘤导向免疫疗法。在这篇综述中,我们将讨论免疫治疗的现状,包括最近的试验结果,正在进行的挑战和未来的方向。
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引用次数: 1
The incidence of pulmonary tuberculosis in patients with anthracosis 炭疽病患者肺结核的发病率
IF 0.7 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2019-07-10 DOI: 10.3934/MEDSCI.2019.3.210
S. Hasani, N. Andisheh, S. Afrasiabian, A. Mohammadi
Background: Anthraco-fibrosis is a potential risk factor for tuberculosis (TB). The aim of this study was to compare the incidence of pulmonary TB in patients with anthracosis and patients without anthracosis. Methods: In this study, all patients who were admitted to the study were selected through enumeration method between 2017 and 2018. Patients with radiological evidence of TB has been considered as suspected of pulmonary TB, and bronchoscopy has been used to detect anthracosis. 40 patients were enrolled as anthracosis patients and 138 as non-anthracosis group. The final diagnosis of active tuberculosis was performed by PCR assay using bronchoalveolar lavage. The data were analyzed by SPSS V.22 using chi-square and logistic regression tests. Results: The incidence of active TB in women and men was 19.3% and 2.1%, respectively (p < 0.001) and the incidence of anthracosis was 28.9% and 16.8% respectively (p = 0.05) which both had a significant difference and were higher in women. Of all patients with anthracosis, 22.5% had active TB. The findings showed that exposure to smoke and anthracosis increases the risk of TB significantly (p < 0.001). Conclusion: The results of this study showed that the patients with anthracosis and those who had long-term exposure to smoke are needed to be evaluated in case of active tuberculosis.
背景:炭疽纤维化是结核病(TB)的潜在危险因素。本研究的目的是比较炭疽病患者和非炭疽病患者的肺结核发病率。方法:本研究采用枚举法选取2017 - 2018年间纳入研究的所有患者。有结核放射学证据的患者被认为是疑似肺结核,支气管镜检查已用于检测炭疽病。40例为炭疽病组,138例为非炭疽病组。通过支气管肺泡灌洗进行PCR检测,最终诊断为活动性肺结核。数据采用SPSS V.22进行分析,采用卡方检验和logistic回归检验。结果:男性和女性活动性结核的发病率分别为19.3%和2.1% (p < 0.001),炭疽病的发病率分别为28.9%和16.8% (p = 0.05),两者差异有统计学意义,且女性较高。在所有炭疽病患者中,22.5%为活动性结核。研究结果表明,暴露于烟雾和炭疽病显著增加结核病的风险(p < 0.001)。结论:本研究结果表明,活动性结核病需要对炭疽病患者和长期接触烟雾者进行评估。
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引用次数: 1
Investigating the relationship between academic burnout and educational factors among students of Guilan University of medical sciences 桂兰医科大学学生学业倦怠与教育因素的关系调查
IF 0.7 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2019-07-07 DOI: 10.3934/medsci.2019.3.230
Soodabeh Gholizadeh Sarcheshmeh, F. Asgari, M. Chehrzad, E. K. Leili
Introduction: Academic burnout is among the factors that negatively affect academic performance and has recently been studied in schools and universities. Aim: The aim of this study was to determine the relationship between academic burnout and educational factors among students of Guilan University of Medical Sciences in 2015–2016. Materials and methods: This cross sectional study was conducted on 532 students who were in second or higher semester of their study in Guilan University of Medical Sciences. The instruments used in this study were the Maslach’s Student Burnout Questionnaire and the Educational Factors Questionnaire. Data were analyzed using SPSS software version 21. Results: A significant relationship was observed between academic burnout and passion in college major (P = 0.0001), failing the courses (P = 0.0001), probation record (P < 0.009), teaching factors, educational environment and educational facilities (P < 0.05). Conclusion: The results of this study indicated a significant relationship between academic burnout and a number of educational factors. As a result, appropriate educational and teaching facilities can reduce students’ academic burnout.
学业倦怠是影响学习成绩的因素之一,最近在学校和大学中得到了研究。目的:本研究旨在了解桂兰医科大学2015-2016学年学生学业倦怠与教育因素的关系。材料与方法:本横断面研究以桂兰医科大学二学期及以上的532名学生为研究对象。本研究使用的工具是马斯拉克学生倦怠问卷和教育因素问卷。数据分析采用SPSS软件21版。结果:学业倦怠与大学生专业热情(P = 0.0001)、不及格(P = 0.0001)、见习记录(P < 0.009)、教学因素、教育环境、教育设施(P < 0.05)存在显著相关。结论:本研究结果显示学业倦怠与多项教育因素有显著的关系。因此,适当的教育和教学设施可以减少学生的学业倦怠。
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引用次数: 3
Gender differences in kidney function and health outcomes 肾功能和健康结局的性别差异
IF 0.7 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2019-07-05 DOI: 10.3934/MEDSCI.2019.3.179
B. Kara
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引用次数: 1
The relationship between facet tropism and lumbar disc herniation in patients with low back pain 腰痛患者关节突向性与腰椎间盘突出的关系
IF 0.7 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2019-07-04 DOI: 10.3934/MEDSCI.2019.3.181
S. arzpeyma, Parisa Hajir, Pooya Bahari Khorram
Introduction: Intervertebral disc herniation is a degenerative lumbar disease and a common pathology of skeletal system. Currently, most experts assume that facet tropism may affect lumbar degenerative diseases. However, the reports on relationship between facet tropism and lumbar disc herniation are inconsistent. Objective: To compare the relationship between facet tropism and lumbar disc herniation. Materials and Methods: In this cross-sectional study, patients with low back pain referring to Radiology Department of Poursina Hospital in 2017–2018 with lumbar disc herniation in only one intervertebral level (L3–L4, L4–L5 or L5–S1) were included. Using gradual sampling, patients were categorized into two case and control groups. Lumbar MRI was performed on all patients and the results were studied by only one professional radiologist. Studied variables were collected with a checklist and analyzed using SPSS software (version 21). Quantitative variables were compared using T-test and qualitative (categorical) variables were compared using Contingency Tables and Chi-Square test and/or Fisher’s Extract. P < 0.05 was identified statistically significant. Findings: Seventy-six patients with lumbar disc herniation were compared in terms of facet tropism presence. Investigating facet tropism in L4–L5 disc showed that percentage of facet tropism incidence in this level was 37% for patients with herniation (n = 10), while it was 10.2% in control group; the difference was statistically significant according to Chi-square test (P = 0.005). In L3-L4 level, percentage of facet tropism incidence in case and control groups were 43.8% (n = 7) and 18.3%, respectively. This 25% difference was statistically significant based on Fisher’s Exact test (P = 0.041). Findings for L5-S1 disc showed no significant relationship. Discussion: Given the inconsistent findings in previous studies on the relationship between facet tropism and lumbar disc herniation, the current study demonstrated the presence of this relationship. This findings can help experts prevent disc herniation to some extents through supportive and preventive measures.
椎间盘突出症是一种腰椎退行性疾病,是骨骼系统的常见病理。目前,大多数专家认为关节突向性可能影响腰椎退行性疾病。然而,关于小关节突向性和腰椎间盘突出之间关系的报道是不一致的。目的:比较关节突向斜与腰椎间盘突出症的关系。材料与方法:本横断面研究纳入2017-2018年在Poursina医院放射科就诊的腰痛患者,腰椎间盘突出仅发生在一个椎间节段(L3-L4、L4-L5或L5-S1)。采用渐进式抽样,将患者分为病例组和对照组。对所有患者进行腰椎MRI检查,结果仅由一名专业放射科医生研究。用检查表收集研究变量,并使用SPSS软件(版本21)进行分析。定量变量比较采用t检验,定性(分类)变量比较采用列联表、卡方检验和/或费雪提取。P < 0.05为差异有统计学意义。结果:我们比较了76例腰椎间盘突出患者的关节突向性表现。对L4-L5椎间盘突向性的调查显示,L4-L5椎间盘突出患者的突向性发生率为37% (n = 10),对照组为10.2%;卡方检验差异有统计学意义(P = 0.005)。在L3-L4水平,病例组和对照组的小关节突向性发生率分别为43.8% (n = 7)和18.3%。根据Fisher精确检验,这25%的差异具有统计学意义(P = 0.041)。L5-S1椎间盘的检查结果无显著相关性。讨论:鉴于先前关于小关节突向性与腰椎间盘突出症之间关系的研究结果不一致,本研究证实了这种关系的存在。这一发现可以帮助专家通过支持和预防措施在一定程度上预防椎间盘突出。
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引用次数: 1
Psychosocial problems among mothers of children with cerebral palsy attending physiotherapy outpatient department of two selected tertiary health centres in Ogun state: A pilot study 在奥贡州两个选定的三级保健中心理疗门诊部就诊的脑瘫儿童母亲的社会心理问题:一项试点研究
IF 0.7 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2019-06-13 DOI: 10.3934/MEDSCI.2019.2.158
O. Michael, Oyewole Olufemi, Falola Jasola, Davis Abigail, Lateef Adetutu, Adepoju Modinat
Background: Caring for a child with cerebral palsy (CP) can be exhausting and stressful. There is paucity of information on the consequence of having a child with CP on mothers of these children. This study explored psychosocial problems encountered by mothers of children with CP receiving physiotherapy care in two selected tertiary health centres in Ogun State, Nigeria. Methods: A qualitative study was conducted through focus group discussion (FGD) utilizing 17 questions identified in the literature as a FGD guide. Participants were seven mothers of children with CP. The framework approach was used for thematic analysis of data. Results: The psychosocial challenges encountered by the mothers were associated with nine common sub-themes. These are: (i) stress of caring for over dependent child; (ii) mothers’ restricted participation in the society; (iii) financial constraint experienced by the mothers of children with CP; (iv) health problems experienced by mothers of children with CP; (v) feelings of uncertainty about the child’s future; (vi) society’s negative perception of child’s problems; (vii) support obtained by the caregivers from others; (viii) availability of support from healthcare facilities; and (ix) Personal belief about condition. Conclusion: Mothers of children with cerebral palsy experience substantial psychological and social problems that are often ignored by the general populace.
背景:照顾一个患有脑瘫(CP)的孩子可能会让人筋疲力尽,压力很大。关于生下患有CP的孩子对这些孩子的母亲的影响的信息很少。本研究探讨了在尼日利亚奥贡州选定的两个三级保健中心接受物理治疗的CP儿童的母亲所遇到的心理社会问题。方法:通过焦点小组讨论(FGD)进行定性研究,利用文献中确定的17个问题作为FGD指南。参与者为7位患有CP儿童的母亲。采用框架方法对数据进行专题分析。结果:母亲所遇到的社会心理挑战与9个共同的子主题有关。这些是:(i)照顾过度依赖儿童的压力;母亲对社会的参与受到限制;(iii)患有脑瘫儿童的母亲所面临的经济困难;(iv)患有脑瘫儿童的母亲遇到的健康问题;对儿童的未来感到不确定;社会对儿童问题的消极看法;(七)照护者从他人获得的支持;(八)从保健设施获得支助的情况;(九)个人对状况的信念。结论:脑瘫患儿的母亲经历了大量的心理和社会问题,而这些问题往往被普通民众所忽视。
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引用次数: 7
Self-esteem and self-confidence relationship with religious tendency in families with a child suffering from cancer 癌症儿童家庭自尊、自信与宗教倾向的关系
IF 0.7 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2019-06-03 DOI: 10.3934/MEDSCI.2019.3.218
Maryam Gholamniya Foumani, N. Sadeghi, S. Dehghanzadeh
Background: Cancer and its diagnosis are one of the most difficult experiences of life during which the family face many spiritual crises and are looking for a definition for anguish and misery. Often the spiritual faith of the patient and their family is lost and their bond is impaired. Thus, the present study attempts to determine self-esteem and self-confidence relationship with religious tendency in families with a child suffering from. Methods: The present cross sectional study, which was a correlation type, was performed with cooperation of 50 parents of children suffering from cancer in 17th Shahrivar hospital in Rasht, in 2017. Gambler and Richie self-esteem, Eysenck self-confidence, and Allport’s religious tendency questionnaires were used to collect data. The data were then entered in SPSS version 21 software. For comparing the variables of self-esteem score, self-confidence, external and internal religious tendency, Mann-Whitney and Kruskal-Wallis tests were used. Findings: Mean and SD of self-confidence score, self-esteem and religious tendency were 97.9 ± 6.8, 82.6 ± 13.9, and 60.1 ± 6.8, respectively. Mean and SD of external and internal score of religious tendency was 48 ± 2.3, and 39 ± 11.3, respectively. Statistical tests showed that the religious tendency scores and the external and internal scores of religious tendency in terms of self-confidence (moderate self-confidence, high self-confidence) were not statistically significant (P > 0.05). Conclusion: According to the findings of this study, highly self-confident parents had a higher mean score than those with moderate self-esteem. Additionally, the external score of religious tendency was higher in single parents and in the first children than in other groups. Given that the present study was conducted for the first time in Iran, it is suggested that parents of cancerous children be supported by the hospital in terms of spirituality, self-confidence and self-esteem during throughout the time of their child admission.
背景:癌症及其诊断是生命中最困难的经历之一,在此期间,家庭面临许多精神危机,并正在寻找痛苦和苦难的定义。病人及其家人的精神信仰往往会丧失,他们之间的纽带也会受损。因此,本研究试图确定自尊、自信与宗教倾向的关系。方法:本横断面研究为相关型研究,于2017年在拉什特市第17沙赫里瓦尔医院与50名癌症患儿家长合作进行。采用赌徒和里奇自尊、艾森克自信和奥尔波特宗教倾向问卷收集数据。然后在SPSS 21版软件中输入数据。自尊得分、自信、外部和内部宗教倾向变量的比较采用Mann-Whitney和Kruskal-Wallis检验。结果:自信评分均值为97.9±6.8分,自尊评分均值为82.6±13.9分,宗教倾向评分标准差为60.1±6.8分。宗教倾向外部评分的平均值为48±2.3,内部评分的标准差为39±11.3。统计检验表明,宗教倾向得分、宗教倾向外部得分和宗教倾向内部得分在自信(中度自信、高度自信)方面均无统计学意义(P > 0.05)。结论:根据本研究的结果,高度自信的父母比中度自尊的父母有更高的平均得分。此外,单亲父母和第一胎子女的宗教倾向外部得分高于其他群体。鉴于本研究是第一次在伊朗进行,建议癌症儿童的父母在整个儿童住院期间得到医院在精神、自信和自尊方面的支持。
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引用次数: 0
Parametric and the Cox risk model in the analysis of factors affecting the time of diagnosis of retinopathy with patients type 2 diabetes 参数及Cox风险模型分析影响2型糖尿病视网膜病变诊断时间的因素
IF 0.7 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2019-05-26 DOI: 10.3934/MEDSCI.2019.2.170
F. Keshavarzi, M. Askarishahi, Maryam Gholamniya Foumani, H. Falahzadeh
Background: The aim of this study was to compare the effectiveness of Cox model and Exponential parametric, Weibull, Log Normal and Log Logistic models in evaluating factors affecting retinopathy diagnostic time in patients with type 2 diabetes. Methods: In this prospective historical study, 400 patients with type 2 diabetes without retinopathy referred to the Ophthalmology Clinic of Yazd Diabetes Research Center in 2008 were followed up for diagnosis of retinopathy by January 2013. Significant variables in the univariate model were introduced into the Cox multivariate and parametric models to determine the effective factors on the time of retinopathy diagnosis. The criterion for comparing the performance of the models was the Akaike’s criterion. All calculations were performed using R software and a significant level of 0.05 was considered. Resuls: The mean and median time of retinopathy diagnosis was 52.46 and 58 months, respectively. 3% of patients in less than one year and 16% of patients in less than two years of retinopathy were diagnosed. Conclusion: According to Akaike’s criterion, Cox model has the best fit in determining the factors affecting the time of retinopathy diagnosis.
背景:本研究的目的是比较Cox模型与指数参数模型、威布尔模型、对数正态模型和对数Logistic模型评价2型糖尿病患者视网膜病变诊断时间影响因素的有效性。方法:对2008年至2013年1月在亚兹德糖尿病研究中心眼科门诊就诊的400例无视网膜病变的2型糖尿病患者进行随访,并对其视网膜病变进行诊断。将单变量模型中的显著变量引入Cox多变量和参数模型,确定影响视网膜病变诊断时间的有效因素。比较模型性能的标准为赤池准则。所有计算均采用R软件进行,考虑显著水平为0.05。结果:视网膜病变诊断的平均时间为52.46个月,中位时间为58个月。3%的患者在不到一年的时间和16%的患者在不到两年的时间内被诊断出视网膜病变。结论:根据赤池标准,Cox模型对确定视网膜病变诊断时间的影响因素具有最佳的拟合性。
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引用次数: 2
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AIMS Medical Science
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