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IBS common features among Northern Saudi population according to Rome IV criteria 根据罗马IV标准,IBS是沙特北部人口的共同特征
IF 0.7 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2019-05-09 DOI: 10.3934/MEDSCI.2019.2.148
S. Alharbi, F. Alateeq, K. Alshammari, H. Ahmed
Background: Irritable Bowel Syndrome (IBS) is a global health disorder characterized heterogenic prevalence worldwide. Therefore, the aim of the present study was to identify the IBS common features among Northern Saudi population according to Rome IV criteria. Methodology: In this community based cross-sectional survey, data about IBS were obtained from 900 Saudi volunteers living in the city of Hail, Northern Saudi Arabia. A Purposeful questionnaire was designed and used for obtaining the necessary data. Each questionnaire was filled by a medical student during the interview. IBS was diagnosed based on Rome IV Criteria. Results: The most common IBS type was mixed followed by constipation and diarrheal, constituting 173/403 (43%), 125/403 (31%) and 105/403 (26%), respectively. The prevalence rates of mixed constipation and diarrheal IBS types among males were 43%, 31.6%, and 25.4%, respectively. The prevalence rates of mixed constipation and diarrheal IBS types among females were 43%, 30.6%, and 26.5%, respectively. Conclusion: The prevalence of rates of IBS using Rome IV, still within medium values among Northern Saudi population, though, there were higher prevalence rates of IBS symptoms. The most common IBS type was mixed followed by constipation and diarrheal types. All IBS related symptoms were more common among women compared to men.
背景:肠易激综合征(IBS)是一种全球性的健康疾病,其特点是世界范围内的异质性流行。因此,本研究的目的是根据罗马IV标准确定沙特北部人群中肠易激综合征的共同特征。方法:在这项以社区为基础的横断面调查中,从居住在沙特阿拉伯北部城市海尔的900名沙特志愿者中获得了有关肠易激综合征的数据。设计了一份目的明确的问卷,用于获取必要的数据。每一份问卷都由一名医学生在访谈中填写。IBS是根据Rome IV标准诊断的。结果:最常见的IBS类型为混合型,其次为便秘和腹泻,分别占173/403(43%)、125/403(31%)和105/403(26%)。男性混合便秘型和腹泻型IBS患病率分别为43%、31.6%和25.4%。女性混合便秘型和腹泻型IBS患病率分别为43%、30.6%和26.5%。结论:在沙特北部人群中,使用Rome IV的IBS患病率仍处于中等水平,尽管IBS症状的患病率较高。最常见的肠易激综合征类型是混合型,其次是便秘型和腹泻型。与男性相比,所有IBS相关症状在女性中更常见。
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引用次数: 6
Down-regulation of IRF3 expression in Relapse-Remitting MS patients IRF3在复发缓解型MS患者中的表达下调
IF 0.7 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2019-04-24 DOI: 10.3934/MEDSCI.2019.2.140
Sobhan Helbi, Zahra Engardeh, Sahar Nickbin poshtamsary, Z. Aminzadeh, N. Jivad
Background: Relapsing-Remitting (RRMS) is the most common Multiple Sclerosis disease course. Interferon regulatory factor 3 (IRF3) as major regulators of immune system genes plays a critical role in the activation of type I interferons promoters, in particular IFNβ promoter. Hence we aimed to evaluate the expression rate of IRF3 in RRMS patients under different type of IFNβ treatment. Material and methods: In the present study total of 100 subjects participated. Blood samples of 25 patients with RRMS newly diagnosed who have not been treated with interferon components, 25 patients with RRMS treated with Interferon beta-1α (B1a), 25 patients with RRMS treated with Interferon beta-1β (B1b) and 25 control samples were collected. The samples were transferred at standard conditions to the Cellular and Molecular Research Center of Shahrekord University of Medical Sciences, RNA was extracted and converted to cDNA. To evaluate the expression of IRF3 the Real-Time PCR method using SYBR Green dye was done. The level of gene expression was measured by a comparative threshold cycle formula. The obtained data were analyzed using SPSS v15 software. Results: In the study we compared the IRF3 mRNA expression of all subjects in association with gender, which no significant difference was seen (P > 0.05). Also assessment of the gene mRNA level in study groups revealed that the B1b, B1a and new case group had the lowest expression respectively. Moreover, comparison of the mRNA level between new case and B1b groups showed remarkable difference (P 0.05). Conclusion: Perhaps the IFNβ recombinants decreases the IRF3 expression as a negative feedback mechanism. Overall the data reported here, supports the previous studies in important role of IRF3 in autoimmune inflammatory disease of CNS and Multiple Sclerosis.
背景:复发缓解(RRMS)是多发性硬化症最常见的病程。干扰素调节因子3 (IRF3)作为免疫系统基因的主要调节因子,在I型干扰素启动子,特别是IFNβ启动子的激活中起着关键作用。因此,我们旨在评估不同类型IFNβ治疗下RRMS患者中IRF3的表达率。材料与方法:本研究共纳入100名受试者。收集25例未接受干扰素成分治疗的新诊断RRMS患者、25例接受干扰素β -1α (B1a)治疗的RRMS患者、25例接受干扰素β -1β (B1b)治疗的RRMS患者和25例对照样本。在标准条件下将样品转移到Shahrekord医科大学细胞和分子研究中心,提取RNA并转化为cDNA。采用SYBR绿染料实时荧光定量PCR法检测IRF3的表达。通过比较阈值周期公式测量基因表达水平。采用SPSS v15软件对所得数据进行分析。结果:本研究比较了不同性别受试者IRF3 mRNA的表达,差异无统计学意义(P > 0.05)。同时对各研究组基因mRNA水平的评估显示,B1b组、B1a组和新病例组分别表达量最低。新病例组与B1b组mRNA水平比较差异有统计学意义(p0.05)。结论:IFNβ重组物降低IRF3表达可能是一种负反馈机制。综上所述,本文报道的数据支持了先前关于IRF3在中枢神经系统自身免疫性炎症性疾病和多发性硬化症中的重要作用的研究。
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引用次数: 0
Diet in Gestational Diabetes Mellitus is important — but much remains to be done! 妊娠期糖尿病患者的饮食很重要,但还有很多工作要做!
IF 0.7 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2019-02-20 DOI: 10.3934/medsci.2019.1.128
S. Shyam, A. Ramadas
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引用次数: 0
The relationship between the stroke survivors’ functional status and their informal caregivers’ burden and quality of life 脑卒中幸存者功能状况与非正式照护者负担及生活质量的关系
IF 0.7 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2019-02-12 DOI: 10.3934/MEDSCI.2019.1.115
Aysegul Celik, B. Kara
Background and purpose: Stroke is a major cause of disability and affects the lives of both the patients and their caregivers. The purpose of the study was to determine the relationship between the functional status of stroke survivors and the care burden and quality of life of their informal caregivers. The relationship between selected socio-demographic variables and the caregivers’ caregiving experiences, quality of life, and care burden also was investigated. Methods: This cross-sectional study consisted of 100 patients and informal caregivers dyads. The Patient and Caregiver Information Form was used to collect demographic data; the Functional Independence Measure (FIM) and Barthel Index (BI) were used to assess functional status; the Caregiver Burden Scale (CBS) and 36-Item Short-Form Health Survey Quality of Life Scale (SF36-QLS) were used to assess the caregivers’ burden and quality of life. Data were evaluated using descriptive statistics, Kolmogorov-Smirnov test, and parametric and non-parametric tests. Results: The mean FIM and BI scores of the patients were 61.0 ± 30.0 and 42.6 ± 28.3, respectively. The caregivers’ average score in the SF36-QLS subscale of general health perception was 51.7 ± 22.7; their average CBS score was 39.2 ± 13.8. The caregivers’ quality of life was found to be moderate to high in the domains of physical function, social function, mental health, bodily pain, and general health, but low in the domains of physical role function, emotional role function, and vitality. There was a negative correlation between the average FIM and BI scores of stroke survivors and their caregivers’ CBS scores or scores on the SF36-QLS subscale of general health perception. Conclusion: There is a relationship between the stroke survivors’ functional status and their caregivers’ burden and quality of life. The caregivers’ quality of life decreased and their care burden increased as the functional status of the patients deteriorated.
背景和目的:中风是致残的主要原因,影响患者及其护理人员的生活。本研究的目的是确定中风幸存者的功能状态与其非正式照顾者的照顾负担和生活质量之间的关系。所选社会人口学变量与照护者的照护经验、生活质量和照护负担之间的关系也被调查。方法:本横断面研究由100名患者和非正式护理人员组成。使用患者和护理人员信息表收集人口统计数据;功能独立度量(FIM)和Barthel指数(BI)评价功能状态;采用照顾者负担量表(CBS)和36项简明健康调查生活质量量表(SF36-QLS)评估照顾者负担和生活质量。采用描述性统计、Kolmogorov-Smirnov检验、参数检验和非参数检验对数据进行评价。结果:患者FIM和BI平均评分分别为61.0±30.0和42.6±28.3。照护者一般健康知觉SF36-QLS子量表平均得分为51.7±22.7分;平均CBS评分为39.2±13.8。照顾者的生活质量在身体功能、社会功能、心理健康、身体疼痛和一般健康方面处于中高水平,但在身体角色功能、情感角色功能和活力方面处于低水平。脑卒中幸存者的平均FIM和BI得分与其照顾者的CBS得分或SF36-QLS一般健康感知亚量表得分之间存在负相关。结论:脑卒中幸存者的功能状况与照顾者负担和生活质量有关。随着患者功能状况的恶化,护理人员的生活质量下降,护理负担加重。
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引用次数: 5
Beyond “#endpjparalysis”, tackling sedentary behaviour in health care 除了“#结束瘫痪”,在医疗保健中解决久坐行为问题
IF 0.7 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2019-01-31 DOI: 10.3934/MEDSCI.2019.1.67
S. Chastin, Juliet A. Harvey, P. Dall, Lianne McInally, A. Mavroeidi, D. Skelton
Reducing Sedentary Behaviour after hospitalization starts with reducing sedentary behaviour whilst in hospital. Although we have eradicated immobilisation as a therapeutic tool due to its potent detrimental effects, it is still in systemic use within health care systems and hospitals. Evidence shows that when in hospital, patients spend most of their time sedentary. In this editorial, we explore the determinants of, and a system-based approach to, reducing sedentary behaviour in health care.
减少住院后的久坐行为从减少住院期间的久坐行为开始。尽管由于其强大的有害影响,我们已经根除了作为一种治疗工具的固定,但它仍在卫生保健系统和医院中系统使用。有证据表明,在医院里,病人大部分时间都是久坐不动的。在这篇社论中,我们探讨了在卫生保健中减少久坐行为的决定因素和基于系统的方法。
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引用次数: 11
Maternal dietary patterns, diet quality and micronutrient status in gestational diabetes mellitus across different economies: A review 不同经济体孕妇饮食模式、饮食质量和微量营养素状况对妊娠糖尿病的影响
IF 0.7 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2019-01-24 DOI: 10.3934/MEDSCI.2019.1.76
S. Misra, Yang Wai Yew, Tan Seok Shin
Gestational diabetes mellitus (GDM) is one of the most common metabolic disorders known to develop during pregnancy. Besides obesity and sedentary lifestyles being the main predisposing factors, dietary measures play an important role in its progression too. Hence, managing GDM has become a great challenge for healthcare professionals globally. It is pertinent to establish and manage the predisposing factors for GDM. Many studies have investigated the potential dietary risk factors linked to GDM, especially dietary patterns and diet quality. While certain healthful dietary patterns incorporating wholegrain cereals, high in fruits and vegetables, low meat and saturated fats have been protective against GDM, deficiencies of micronutrients such as potassium, magnesium, and possibly zinc and chromium may predispose one to carbohydrate intolerance. The alterations in iron and zinc body stores could also affect GDM. Dietary iron, vitamin C and D are amongst the micronutrients associated with the development and prevention of diabetes in pregnant women. However, evidences on the effects of vitamins, minerals other indices of maternal diet quality on GDM are inconclusive. This review provides an overview of the emerging evidences on the role of maternal dietary patterns, diet quality and micronutrients, which may contribute in the prevention of GDM across the different economies in the world. The results will empower the healthcare professionals to prevent and manage GDM effectively.
妊娠期糖尿病(GDM)是妊娠期最常见的代谢紊乱之一。除了肥胖和久坐不动的生活方式是主要的诱发因素外,饮食措施在其发展中也起着重要作用。因此,管理GDM已成为全球医疗保健专业人员面临的巨大挑战。建立和管理GDM的易感因素是有针对性的。许多研究调查了与GDM相关的潜在饮食风险因素,特别是饮食模式和饮食质量。虽然某些健康的饮食模式,包括全麦谷物、多吃水果和蔬菜、少吃肉和饱和脂肪,可以预防GDM,但缺乏微量营养素,如钾、镁、锌和铬,可能会使人容易产生碳水化合物不耐症。体内铁和锌含量的变化也可能影响GDM。饮食中的铁、维生素C和D是与孕妇糖尿病的发生和预防有关的微量营养素。然而,维生素、矿物质等母体饮食质量指标对GDM的影响尚无定论。这篇综述概述了关于母亲饮食模式、饮食质量和微量营养素的作用的新证据,这些证据可能有助于预防全球不同经济体的GDM。结果将使医疗保健专业人员能够有效地预防和管理GDM。
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引用次数: 1
Role of mushrooms in gestational diabetes mellitus 蘑菇在妊娠期糖尿病中的作用
IF 0.7 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2019-01-21 DOI: 10.3934/MEDSCI.2019.1.49
V. Gulati, Mansi Singh, Pankaj Gulati
Many studies have shown that plant-based diets and Mediterranean diets can lower the risk of development of gestational diabetes mellitus. Plants have been the main source of medicines since ancient times. Despite tremendous advances in medicinal chemistry, synthetic drugs have not provided cures to many diseases due to their adverse side effects or diminution in response after prolonged use. Medicinal mushrooms have been used traditionally as an anti-diabetic food for centuries especially in countries such as China, Japan, India and Korea. These are source of natural bioactive compounds. The bioactive constituents are polysaccharides, proteins, dietary fibres, lectins, lactones, alkaloids, terpenoids, sterols and phenolic compounds which have various health benefits. This review will focus on recent examples of diverse types of mushrooms that have been validated by scientific evaluation as having promising activity for the prevention and/or treatment of gestational diabetes mellitus. Dietary components and plant-derived molecules can be used in the future to complement current treatment strategies for gestational diabetes mellitus.
许多研究表明,植物性饮食和地中海饮食可以降低患妊娠糖尿病的风险。自古以来,植物就是药物的主要来源。尽管药物化学取得了巨大的进步,但合成药物由于其不良副作用或长期使用后反应减弱而未能治愈许多疾病。几个世纪以来,特别是在中国、日本、印度和韩国等国家,药用蘑菇一直被传统地用作抗糖尿病食品。这些是天然生物活性化合物的来源。生物活性成分是多糖、蛋白质、膳食纤维、凝集素、内酯、生物碱、萜类、甾醇和酚类化合物,它们对健康有各种好处。这篇综述将集中在不同类型的蘑菇最近的例子,这些蘑菇已经被科学评估证实,在预防和/或治疗妊娠糖尿病方面有希望的活性。膳食成分和植物源性分子可以在未来用于补充当前妊娠糖尿病的治疗策略。
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引用次数: 9
Putting psychology into telerehabilitation: Coping planning as an example for how to integrate behavior change techniques into clinical practice 将心理学应用于远程康复:以应对计划为例,探讨如何将行为改变技术融入临床实践
IF 0.7 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2019-01-14 DOI: 10.3934/medsci.2019.1.13
L. Fleig, M. Ashe, J. Keller, S. Lippke, R. Schwarzer
Background: Behavioral interventions based on psychological theory can facilitate continued recovery after discharge from cardiac or orthopedic rehabilitation. For example, health professionals can encourage patients to engage in coping planning to support the maintenance of physical activity. Telephone-based interviews or web-based interventions are two promising delivery modes to provide such after-care services from a distance (telerehabilitation). However, previous evaluations of such behavioral interventions lack a detailed description of the specific content, and its connection to psychosocial antecedents and health outcomes. Therefore, the primary aim of this study was to (i) describe the content of user-specified coping plans. Second, we aimed to identify (ii) coping plan characteristics associated with health outcomes post-rehabilitation and (iii) socio-demographic and psychosocial variables associated with coping plan characteristics. Methods: This was a secondary analysis from a larger behavioral intervention study, using remote delivery modes, within orthopedic and cardiac rehabilitation. Two raters evaluated the content, quality and number of coping plans from 231 participants. Physical activity and quality of life (health outcomes) were measured via self-reports at the end of rehabilitation and six months after discharge. We used linear regression analyses to examine the relationship between plan characteristics and health outcomes. Results: Content analyses of participants’ coping plans emphasized that physical barriers such as pain or other health limitations presented major obstacles for engagement in physical activity post-rehabilitation. The most frequently identified external barriers to physical activity were workload, family obligations or bad weather. There was a statistically significant difference in quality of life and physical activity for participants who formulated highly instrumental coping plans (higher quality of life and activity) compared with participants with coping plans of lower quality (lower quality of life and activity). The number of plans (quantity) was not related with outcomes. Conclusion: Generating coping plans can be a useful theory-based approach for inclusion in telerehabilitation to facilitate the maintenance of physical activity and quality of life. It is important to encourage adults and older adults to engage in coping planning and, specifically, to formulate strategies that support tenacious plan pursuit.
背景:基于心理学理论的行为干预可以促进心脏或骨科康复出院后的持续康复。例如,卫生专业人员可以鼓励患者参与应对计划,以支持身体活动的维持。以电话为基础的访谈或基于网络的干预是远距离提供此类护理后服务(远程康复)的两种有希望的交付模式。然而,以往对此类行为干预的评估缺乏对具体内容及其与心理社会前因和健康结果的联系的详细描述。因此,本研究的主要目的是(i)描述用户指定应对计划的内容。其次,我们的目的是确定(ii)与康复后健康结果相关的应对计划特征和(iii)与应对计划特征相关的社会人口统计学和社会心理变量。方法:这是一项大型行为干预研究的二次分析,采用远程交付模式,在骨科和心脏康复领域。两名评分员对231名参与者的应对计划的内容、质量和数量进行了评估。身体活动和生活质量(健康结果)在康复结束时和出院后6个月通过自我报告进行测量。我们使用线性回归分析来检验计划特征与健康结果之间的关系。结果:参与者应对计划的内容分析强调,身体障碍,如疼痛或其他健康限制是参与康复后体育活动的主要障碍。最常见的身体活动外部障碍是工作量、家庭义务或恶劣天气。制定高工具性应对计划(高生活质量和高活动)的参与者与制定低质量应对计划(低生活质量和低活动)的参与者在生活质量和身体活动方面存在统计学上的显著差异。计划的数量(数量)与结果无关。结论:制定应对计划是一种有效的基于理论的方法,有助于远程康复患者保持身体活动和生活质量。重要的是要鼓励成年人和老年人参与应对计划,特别是制定支持顽强计划追求的策略。
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引用次数: 1
Older adults’ activity on a geriatric hospital unit: A behavioral mapping study 老年人在老年医院单位的活动:一项行为测绘研究
IF 0.7 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2019-01-04 DOI: 10.3934/medsci.2019.1.33
P. Ariza-Vega, Hattie Shu, Ruvini Amarasekera, Nicola Edwards, Marta Filipski, D. Langford, K. Madden, M. Ashe
Background: Systematic reviews highlight a preponderance of prolonged sedentary behavior in the hospital setting, with possible consequences for patients’ health and mobility. To date, most of the published literature in this field focus on the hospital experience for older adults with dementia or stroke. Few data describe hospital activity patterns in specialized geriatric units for frail older adults, who are already at risk of spending prolonged periods of time sitting. Yet, promoting older adults’ activity throughout hospitalization, when possible, is an avenue for exploration to identify opportunities to encourage more daily functional activities, and minimize the risk of post-hospital syndrome. Methods: This was a two-part observational study to describe (1) the hospital indoor environment and (2) patients’ activity patterns (using behavioral mapping) within public areas of two hospital units. One combined-trained physiotherapist and occupational therapist recorded information on indoor environmental features for two acute geriatric hospital units, such as potential opportunities for sitting and walking (i.e., handrails, chairs, benches, etc.), and identified obstacles which may impede activity (i.e., food or laundry carts in hallways, etc.). The observer also systematically scanned these units every 15 minutes (8 am to 4 pm) over two days/unit (one weekday and one weekend day) using standard behavioral mapping methods. There were three to four observation stations identified on each unit to count the number of people who were present, distinguish their role (patient, visitor), approximate age, gender, and body position or activity (sitting, standing, walking). We did not enter patients’ rooms. We described units’ indoor environment, and observed activity for each unit. We used Chi square tests to compare differences in observations between units, day of the week, and gender. Results: For both units there were similar indoor environmental features, with the exception of the floorplans, number of beds, minor differences in flooring materials, and an additional destination room (two lounges attached to one unit). Both units had items such as laundry carts against walls in hallways, blocking handrails, when present. We observed between 46–86% (average 60%) of admitted patients in the public areas of hospital units, with variability depending on unit and day: More than half of the observations were of patients sitting. Approximately 20% of patients were observed more than once: This included five women and seven men. There were significant associations for gender and observations on weekdays (men > women; Chi square = 17.01, p men; Chi square = 6.11, p = 0.013). There were more visitor observations on Unit 2. Conclusions: These exploratory findings are an opportunity to, generate hypotheses for future testing, and act as a starting point to collaborate with front line clinicians to highlight the indoor environment’s role in promoting activity,
背景:系统综述强调了医院环境中长时间久坐行为的优势,这可能对患者的健康和行动能力产生影响。迄今为止,该领域发表的大多数文献都集中在老年痴呆症或中风患者的住院经验上。很少有数据描述针对体弱多病的老年人的专门老年病房的医院活动模式,这些老年人已经有长时间坐着的风险。然而,在可能的情况下,促进老年人在整个住院期间的活动是一种探索途径,以确定鼓励更多日常功能活动的机会,并最大限度地减少院后综合征的风险。方法:这是一个两部分的观察性研究来描述(1)医院室内环境和(2)患者的活动模式(使用行为测绘)在两个医院单位的公共区域。一位受过综合训练的物理治疗师和职业治疗师记录了两个急性老年医院病房的室内环境特征信息,例如坐下和行走的潜在机会(即扶手、椅子、长凳等),并确定了可能妨碍活动的障碍物(即走廊上的食物或洗衣车等)。在2天/单位(一个工作日和一个周末)中,观察者还使用标准行为映射方法系统地每15分钟(上午8点至下午4点)扫描这些单元。每个单元有三到四个观察站,用于计算在场的人数,区分他们的角色(病人,来访者),大致年龄,性别和身体位置或活动(坐,站,走)。我们没有进入病人的房间。我们描述了每个单元的室内环境,并观察了每个单元的活动。我们使用卡方检验来比较单位、星期几和性别之间观察结果的差异。结果:除了平面图、床的数量、地板材料的细微差异和一个额外的目的地房间(两个休息室附属于一个单元)之外,两个单元的室内环境特征相似。这两套公寓都有一些物品,比如洗衣车靠在走廊的墙上,挡住了扶手。我们观察了46-86%(平均60%)住院病人在医院单位的公共区域,差异取决于单位和日期:超过一半的观察是坐着的病人。大约20%的患者被观察不止一次:其中包括5名女性和7名男性。性别和工作日的观察结果存在显著关联(男性比女性多;卡方= 17.01,p男性;卡方= 6.11,p = 0.013)。第二单元有更多的参观者观察。结论:这些探索性发现是一个机会,为未来的测试产生假设,并作为一个起点,与一线临床医生合作,强调室内环境在促进活动方面的作用,并制定未来的策略,以安全地将更多的活动引入老年人的急性护理环境。
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引用次数: 2
Effect of diabetes educational program on self-care and diabetes control among type 2 diabetic patients in Al-Baha–Saudi Arabia 糖尿病教育项目对Al-Baha-Saudi Arabia地区2型糖尿病患者自我保健和糖尿病控制的影响
IF 0.7 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2019-01-01 DOI: 10.3934/medsci.2019.3.239
Neimat Mahmoud Abd-Alrahman Ali Dinar, Ghassan Abd-Al lateef Mohammad Al sammouri, Mohammed Abdalla Eltahir, Aida Ahmed Fadlala Ahmed, Hasen Jamaan Ahmed Alghamdi, Abdulrahman Ali Alghamdi, Waled Amen Mohammed Ahmed
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引用次数: 0
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