Pub Date : 2021-05-21DOI: 10.1177/23202068211018984
Ramesh Bharti, A. Tikku, A. Chandra, Prashant Gupta
Aim: To evaluate the effectiveness of photodynamic therapy (PDT), sodium hypochlorite (NaOCl) and chlorhexidine gluconate (CHO) in the endodontic re-treatment in the removing of microorganisms from previously filled infected root canals. Materials and Methods: The study samples consist of 54 root canal treated anterior teeth with apical periodontitis were randomly divided into three groups according to the disinfection protocol. Microbiological samples from the root canals were collected after removing the gutta-percha (S1) and following the endodontic re-treatment (S2) with either 5% NaOCl, 2% CHO or PDT procedure for 1 minute. Microbiological samples were cultivated on selective plates to assess the presence or absence of microbial growth and determine the average reduction of viable microorganisms. Results: Significant reduction in the total bacterial count in all the groups at post treatment (P < .001). PDT provided statistically higher (99.74%) elimination of Enterococcus faecalis in comparison to NaOCl (95%) and CHO (88%). Conclusions: The use of PDT in endodontic re-treatment led to the significant reduction of the remaining bacterial species. So, PDT can be used for routine endodontic disinfection in failed root canal cases.
{"title":"Antimicrobial Effectiveness of Photodynamic Therapy, 5% Sodium Hypochlorite and 2% Chlorhexidine Gluconate in Root Canal Treated Teeth: A Clinical Study","authors":"Ramesh Bharti, A. Tikku, A. Chandra, Prashant Gupta","doi":"10.1177/23202068211018984","DOIUrl":"https://doi.org/10.1177/23202068211018984","url":null,"abstract":"Aim: To evaluate the effectiveness of photodynamic therapy (PDT), sodium hypochlorite (NaOCl) and chlorhexidine gluconate (CHO) in the endodontic re-treatment in the removing of microorganisms from previously filled infected root canals. Materials and Methods: The study samples consist of 54 root canal treated anterior teeth with apical periodontitis were randomly divided into three groups according to the disinfection protocol. Microbiological samples from the root canals were collected after removing the gutta-percha (S1) and following the endodontic re-treatment (S2) with either 5% NaOCl, 2% CHO or PDT procedure for 1 minute. Microbiological samples were cultivated on selective plates to assess the presence or absence of microbial growth and determine the average reduction of viable microorganisms. Results: Significant reduction in the total bacterial count in all the groups at post treatment (P < .001). PDT provided statistically higher (99.74%) elimination of Enterococcus faecalis in comparison to NaOCl (95%) and CHO (88%). Conclusions: The use of PDT in endodontic re-treatment led to the significant reduction of the remaining bacterial species. So, PDT can be used for routine endodontic disinfection in failed root canal cases.","PeriodicalId":43017,"journal":{"name":"Journal of Advanced Oral Research","volume":"1 1","pages":"193 - 199"},"PeriodicalIF":0.7,"publicationDate":"2021-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91243394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-19DOI: 10.1177/23202068211015748
Abdolrasoul Rangrazi, Amirtaher Mirmortazavi, Reyhaneh Imani, D. Nodehi
Aim: The aim of this study was to evaluate the effect of the ozonated water on corrosion of a cobalt–chromium (Co-Cr)-based alloy, which is applied for the fabrication of metal frameworks of removable partial dentures. Materials and Methods: In this in vitro study, a total of 30 disk-shaped samples of a Co-Cr alloy were papered and randomly divided into two groups of 15 specimens. In group 1 (control), the specimens were stored in distilled water (DW), and in group 2, the specimens were stored in ozonated water. Around 90 immersions were performed, and the weight change of each specimen was determined. The ion release was analyzed using an inductively coupled plasma-optical emission spectrophotometer. The potentiodynamic polarization test was performed for each group to assess the corrosion resistance of the Co-Cr alloy. The statistical analysis was performed using SPSS version 22. Data were analyzed by independent samples’ t-test. Results: The results showed no significant difference between the weight changes of the two groups. The test using an inductively coupled plasma-optical emission spectrophotometer demonstrated no significant difference between the groups in Co and Cr ions release. In the potentiodynamic polarization test, both groups present similar corrosion behavior, and ozonated water has no deleterious effect on the corrosion resistance and passive range of the Co-Cr alloy compared to DW. Conclusion: As compared to DW, ozonated water has no significant deleterious effect on the corrosion resistance of the Co-Cr frameworks and can be used for cleaning the removable partial dentures.
{"title":"Effect of Ozone on Corrosion Behavior of a Cobalt–Chromium Alloy Used in Removable Partial Denture Framework: An In Vitro Study","authors":"Abdolrasoul Rangrazi, Amirtaher Mirmortazavi, Reyhaneh Imani, D. Nodehi","doi":"10.1177/23202068211015748","DOIUrl":"https://doi.org/10.1177/23202068211015748","url":null,"abstract":"Aim: The aim of this study was to evaluate the effect of the ozonated water on corrosion of a cobalt–chromium (Co-Cr)-based alloy, which is applied for the fabrication of metal frameworks of removable partial dentures. Materials and Methods: In this in vitro study, a total of 30 disk-shaped samples of a Co-Cr alloy were papered and randomly divided into two groups of 15 specimens. In group 1 (control), the specimens were stored in distilled water (DW), and in group 2, the specimens were stored in ozonated water. Around 90 immersions were performed, and the weight change of each specimen was determined. The ion release was analyzed using an inductively coupled plasma-optical emission spectrophotometer. The potentiodynamic polarization test was performed for each group to assess the corrosion resistance of the Co-Cr alloy. The statistical analysis was performed using SPSS version 22. Data were analyzed by independent samples’ t-test. Results: The results showed no significant difference between the weight changes of the two groups. The test using an inductively coupled plasma-optical emission spectrophotometer demonstrated no significant difference between the groups in Co and Cr ions release. In the potentiodynamic polarization test, both groups present similar corrosion behavior, and ozonated water has no deleterious effect on the corrosion resistance and passive range of the Co-Cr alloy compared to DW. Conclusion: As compared to DW, ozonated water has no significant deleterious effect on the corrosion resistance of the Co-Cr frameworks and can be used for cleaning the removable partial dentures.","PeriodicalId":43017,"journal":{"name":"Journal of Advanced Oral Research","volume":"76 1","pages":"304 - 309"},"PeriodicalIF":0.7,"publicationDate":"2021-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77313773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-19DOI: 10.1177/23202068211015447
F. Farzanegan, Hooman Shafaee, M. Darroudi, Abdolrasoul Rangrazi
Aim: This in vitro study was aimed to evaluate the effect of adding different concentrations of chitosan nanoparticles (NPs) and TiO2 NPs on the shear bond strength (SBS) of an orthodontic adhesive. Materials and Methods: In this in vitro study, 72 extracted human premolars were embedded in an acrylic resin and randomly allocated into four groups of 18 specimens. In group 1 (control), brackets were bonded to the tooth with the Transbond XT orthodontic adhesive. In groups 2, 3, and 4, 0.5% chitosan NPs and 0.5% TiO2 NPs, 1% chitosan NPs and 1% TiO2 NPs, and 1.5% chitosan NPs and 1.5% TiO2 NPs were added to Transbond XT, respectively. Then, the brackets were bonded by the modified adhesive. The SBS and adhesive remnant index (ARI) of each group were assessed with a universal testing machine. The SBS test results were analyzed using one-way analysis of variance followed by the posthoc Tukey’s honestly significant difference (HSD) test. The Kruskal–Wallis test was also applied to evaluate the ARI scores. Results: The results showed no statistically significant difference between groups 1, 2, and 3, but SBS decreased significantly in group 4. With increasing the concentration of NPs up to 1% chitosan NPs and 1% TiO2 NPs, SBS did not change significantly. However, in 1.5% chitosan NPs and 1.5% TiO2 NPs, SBS decreased compared to the other three groups. No significant differences were found between the groups in terms of ARI scores. Conclusion: It is concluded that the orthodontic composite containing 1% chitosan NPs and 1% TiO2 NPs has adequate SBS for use in the clinical setting.
{"title":"Effect of the Incorporation of Chitosan and TiO2 Nanoparticles on the Shear Bond Strength of an Orthodontic Adhesive: An In Vitro Study","authors":"F. Farzanegan, Hooman Shafaee, M. Darroudi, Abdolrasoul Rangrazi","doi":"10.1177/23202068211015447","DOIUrl":"https://doi.org/10.1177/23202068211015447","url":null,"abstract":"Aim: This in vitro study was aimed to evaluate the effect of adding different concentrations of chitosan nanoparticles (NPs) and TiO2 NPs on the shear bond strength (SBS) of an orthodontic adhesive. Materials and Methods: In this in vitro study, 72 extracted human premolars were embedded in an acrylic resin and randomly allocated into four groups of 18 specimens. In group 1 (control), brackets were bonded to the tooth with the Transbond XT orthodontic adhesive. In groups 2, 3, and 4, 0.5% chitosan NPs and 0.5% TiO2 NPs, 1% chitosan NPs and 1% TiO2 NPs, and 1.5% chitosan NPs and 1.5% TiO2 NPs were added to Transbond XT, respectively. Then, the brackets were bonded by the modified adhesive. The SBS and adhesive remnant index (ARI) of each group were assessed with a universal testing machine. The SBS test results were analyzed using one-way analysis of variance followed by the posthoc Tukey’s honestly significant difference (HSD) test. The Kruskal–Wallis test was also applied to evaluate the ARI scores. Results: The results showed no statistically significant difference between groups 1, 2, and 3, but SBS decreased significantly in group 4. With increasing the concentration of NPs up to 1% chitosan NPs and 1% TiO2 NPs, SBS did not change significantly. However, in 1.5% chitosan NPs and 1.5% TiO2 NPs, SBS decreased compared to the other three groups. No significant differences were found between the groups in terms of ARI scores. Conclusion: It is concluded that the orthodontic composite containing 1% chitosan NPs and 1% TiO2 NPs has adequate SBS for use in the clinical setting.","PeriodicalId":43017,"journal":{"name":"Journal of Advanced Oral Research","volume":"28 1","pages":"261 - 266"},"PeriodicalIF":0.7,"publicationDate":"2021-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78342679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-17DOI: 10.1177/23202068211015878
Shruthi H. Attavar, M. Hegde
Aim: The effective delivery of irrigants into the inaccessible areas of the root canal system is the prerequisite for a proper disinfection of the root canal system. Numerous activation devices that can provide effective delivery of the irrigant and aid in the success of the root canal treatment are available. The activation of irrigants has claimed to be effective in in vitro and clinical trials. Hence, the present systematic review aims to analyze the effect of irrigants and irrigating devices in disinfecting the root canal system. Materials and Methods: A literature search was undertaken in PubMed, Cochrane, Web of Science, and Scopus databases. The inclusion criteria included clinical trials, both in vivo and ex vivo. The exclusion criteria included animal studies, textbooks, review articles, and case reports. The patients who required endodontic treatment along with the activation of irrigants were chosen as participants for the review. Result: The search strategy screened around 132 articles, out of which only 10 were selected for the present systematic review. The risk of bias was calculated based on the following scores: 3, high; 2, moderate; and 1, low. In the present systematic review, four articles were categorized into low-risk bias, three articles were classified as moderate risk, and three articles belonged to the high-risk category. Conclusion: The present systematic review concluded that the use of a mechanical activation device along with the irrigant will help in better removal of the smear layer and debris from the root canal system, improving the cleanliness and helping achieve more successful endodontic treatment.
目的:有效地将冲洗剂输送到根管系统不可接近的区域是根管系统适当消毒的先决条件。许多激活装置可以提供有效的灌洗剂的输送，并有助于根管治疗的成功。在体外和临床试验中，冲洗剂的活化声称是有效的。因此，本系统综述旨在分析冲洗剂和冲洗装置在根管系统消毒中的作用。材料和方法:在PubMed、Cochrane、Web of Science和Scopus数据库中进行文献检索。纳入标准包括体内和体外的临床试验。排除标准包括动物研究、教科书、综述文章和病例报告。需要根管治疗并激活冲洗剂的患者被选为评估的参与者。结果:检索策略筛选了大约132篇文章，其中只有10篇入选本系统综述。偏倚风险根据以下得分计算:3分，高;2、温和;1，低。在本系统评价中，4篇文章被归为低风险偏倚，3篇文章被归为中度风险偏倚，3篇文章属于高风险偏倚。结论:本系统综述的结论是，机械激活装置配合冲洗剂的使用有助于更好地清除根管系统中的涂抹层和碎屑，提高清洁度，有助于实现更成功的根管治疗。
{"title":"Effect of Irrigants and Irrigating Devices on Disinfection of Root Canal System: A Systematic Review","authors":"Shruthi H. Attavar, M. Hegde","doi":"10.1177/23202068211015878","DOIUrl":"https://doi.org/10.1177/23202068211015878","url":null,"abstract":"Aim: The effective delivery of irrigants into the inaccessible areas of the root canal system is the prerequisite for a proper disinfection of the root canal system. Numerous activation devices that can provide effective delivery of the irrigant and aid in the success of the root canal treatment are available. The activation of irrigants has claimed to be effective in in vitro and clinical trials. Hence, the present systematic review aims to analyze the effect of irrigants and irrigating devices in disinfecting the root canal system. Materials and Methods: A literature search was undertaken in PubMed, Cochrane, Web of Science, and Scopus databases. The inclusion criteria included clinical trials, both in vivo and ex vivo. The exclusion criteria included animal studies, textbooks, review articles, and case reports. The patients who required endodontic treatment along with the activation of irrigants were chosen as participants for the review. Result: The search strategy screened around 132 articles, out of which only 10 were selected for the present systematic review. The risk of bias was calculated based on the following scores: 3, high; 2, moderate; and 1, low. In the present systematic review, four articles were categorized into low-risk bias, three articles were classified as moderate risk, and three articles belonged to the high-risk category. Conclusion: The present systematic review concluded that the use of a mechanical activation device along with the irrigant will help in better removal of the smear layer and debris from the root canal system, improving the cleanliness and helping achieve more successful endodontic treatment.","PeriodicalId":43017,"journal":{"name":"Journal of Advanced Oral Research","volume":"9 1","pages":"181 - 186"},"PeriodicalIF":0.7,"publicationDate":"2021-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83838530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-07DOI: 10.1177/23202068211010768
S. Katti, K. Bhat, Chetana Bogar
Aim: The aim of the current study was to isolate stem cells from various dental sources such as dental pulp, periodontal ligament (PDL), and apical papilla, and to characterize stem cells by staining for the presence/absence of specific surface markers and also to differentiate stem cells into osteogenic, chondrogenic, and adipogenic cell lineages by exposing them to specific growth factors under the ideal conditions. Materials and Methods: A total of 117 samples were included in the study, consisting of 30 pulp, 50 gingival, 35 PDL, and 2 apical papilla samples. The pulp was extirpated and transported to the Central Research Laboratory. Gingival connective tissue was collected from the participants undergoing any crown lengthening procedure or any gingivectomy procedure from the Department of Periodontology. A similar procedure was also followed for apical papilla and PDL. Isolation was done followed by the identification of the cells by immunocytochemistry using different markers. Once the identity of cells was confirmed, these cells were treated with different culture media to attain 70% to 100% confluency. Then the medium was replaced with a conditioning medium containing specific growth factors for differentiation into osteogenic, chondrogenic, and adipogenic cell lineages. Result: In our study, the number of samples collected and processed was 117. The isolation rate of stem cells from the above-collected samples was 70%. Statistical analysis—no statistical analysis was done as there was no variability expected. Conclusion: Our study showed that stem cells could be isolated, differentiated, and characterized from different dental sources.
{"title":"Isolation, Characterization, and Differentiation of Stem Cells From Various Dental Sources: An In Vitro Study","authors":"S. Katti, K. Bhat, Chetana Bogar","doi":"10.1177/23202068211010768","DOIUrl":"https://doi.org/10.1177/23202068211010768","url":null,"abstract":"Aim: The aim of the current study was to isolate stem cells from various dental sources such as dental pulp, periodontal ligament (PDL), and apical papilla, and to characterize stem cells by staining for the presence/absence of specific surface markers and also to differentiate stem cells into osteogenic, chondrogenic, and adipogenic cell lineages by exposing them to specific growth factors under the ideal conditions. Materials and Methods: A total of 117 samples were included in the study, consisting of 30 pulp, 50 gingival, 35 PDL, and 2 apical papilla samples. The pulp was extirpated and transported to the Central Research Laboratory. Gingival connective tissue was collected from the participants undergoing any crown lengthening procedure or any gingivectomy procedure from the Department of Periodontology. A similar procedure was also followed for apical papilla and PDL. Isolation was done followed by the identification of the cells by immunocytochemistry using different markers. Once the identity of cells was confirmed, these cells were treated with different culture media to attain 70% to 100% confluency. Then the medium was replaced with a conditioning medium containing specific growth factors for differentiation into osteogenic, chondrogenic, and adipogenic cell lineages. Result: In our study, the number of samples collected and processed was 117. The isolation rate of stem cells from the above-collected samples was 70%. Statistical analysis—no statistical analysis was done as there was no variability expected. Conclusion: Our study showed that stem cells could be isolated, differentiated, and characterized from different dental sources.","PeriodicalId":43017,"journal":{"name":"Journal of Advanced Oral Research","volume":"117 1","pages":"254 - 260"},"PeriodicalIF":0.7,"publicationDate":"2021-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79362502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-01DOI: 10.1177/2320206820977696
Duygu Karakis, Elif Didem Demi̇rdağ
The occlusal splint has been frequently used as an effective treatment in sleep bruxism patients. In the adjustment procedure of occlusal splint with an optimal occlusion, clinicians usually use conventional methods; however, they cannot measure the surface area of contacts, amount of force, and contacting time sequence. Recently, two separate technologies have been synchronized together: T-Scan III and BioEMG III. In the present case report, an occlusal splint in a patient with sleep bruxism was adjusted with synchronized T-Scan computerized digital occlusal analysis system and BioEMG III. Optimal occlusal parameters were generated, and quantitative analyses of occlusal scheme and muscle activity level were performed before and after the adjustment of the occlusal splint. In the present case report, occlusion of the occlusal splint in a bruxism patient was adjusted with T-Scan III to fulfill the requirement of the optimal occlusion criteria. Before adjustment of occlusal splint, digital evaluation revealed unbalanced force distribution, lengthy occlusion (1.51 s), and disocclusion time (0.09 s) in centric relation. EMG activity of muscles was lower than expected values in centric relation. After adjustment of occlusal splint, canine protected occlusion with appropriate occlusion (0.2 s) and disocclusion (0.4 s) time were performed. Increased electromyography activity of the right anterior temporalis muscle showed a decrease in all excursive movements. Modern occlusal adjustment procedures provide a new standard of verification for the validation of occlusal splint fabrication with optimal occlusion.
{"title":"Adjustment of Occlusal Splint with Synchronized T-Scan III Digital Occlusal Analysis System and Bio-EMG III in a Patient with Sleep Bruxism","authors":"Duygu Karakis, Elif Didem Demi̇rdağ","doi":"10.1177/2320206820977696","DOIUrl":"https://doi.org/10.1177/2320206820977696","url":null,"abstract":"The occlusal splint has been frequently used as an effective treatment in sleep bruxism patients. In the adjustment procedure of occlusal splint with an optimal occlusion, clinicians usually use conventional methods; however, they cannot measure the surface area of contacts, amount of force, and contacting time sequence. Recently, two separate technologies have been synchronized together: T-Scan III and BioEMG III. In the present case report, an occlusal splint in a patient with sleep bruxism was adjusted with synchronized T-Scan computerized digital occlusal analysis system and BioEMG III. Optimal occlusal parameters were generated, and quantitative analyses of occlusal scheme and muscle activity level were performed before and after the adjustment of the occlusal splint. In the present case report, occlusion of the occlusal splint in a bruxism patient was adjusted with T-Scan III to fulfill the requirement of the optimal occlusion criteria. Before adjustment of occlusal splint, digital evaluation revealed unbalanced force distribution, lengthy occlusion (1.51 s), and disocclusion time (0.09 s) in centric relation. EMG activity of muscles was lower than expected values in centric relation. After adjustment of occlusal splint, canine protected occlusion with appropriate occlusion (0.2 s) and disocclusion (0.4 s) time were performed. Increased electromyography activity of the right anterior temporalis muscle showed a decrease in all excursive movements. Modern occlusal adjustment procedures provide a new standard of verification for the validation of occlusal splint fabrication with optimal occlusion.","PeriodicalId":43017,"journal":{"name":"Journal of Advanced Oral Research","volume":"47 1","pages":"170 - 175"},"PeriodicalIF":0.7,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89270186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-01DOI: 10.1177/2320206820981485
M. Tulsani, D. Ganapathy, D. Rupawat, Sanjana Devi
Aim: To evaluate the effectiveness of midazolam and zolpidem on postoperative pain perception in patients undergoing implant placement. Materials and Methods: In the present in vivo study 60 patients undergoing implant placement were selected based on the inclusion criteria framed and were randomly allocated using sequentially numbered, opaque, and sealed envelope (SNOSE) method into 3 groups with 20 patients each after obtaining informed consent. Group A was the control group, Group B received midazolam 7.5 mg 30 minutes before the procedure. Group C received zolpidem 5 mg 30 minutes before the procedure. The anxiety level of patients was recorded using the Corah scale and postoperative pain was recorded after 2 hours of implant placement using the VAS scale. Statistical analysis was done using analysis of variance (ANOVA), one-way multivariate analysis of variance (one-way MANOVA), and then Tukey’s Honestly Significant Difference (HSD) test for comparison among groups at the 0.05 level of significance. Results: Group A had a mean anxiety level of 16 ± 1.451, Group B had a mean anxiety level of 11.2 ± 2.858, and Group C had a mean anxiety level of 13 ± 2.9019 and a statistically significant difference between the groups was observed (P < .05). The mean for the postoperative pain perception for Group A was 6.8 ± 1.1965, for Group B was 3.8 ± 1.3611, and Group C was 5 ± 1.451 and a statistically significant difference between the groups was observed (P < .05). Conclusion: This study concluded that both midazolam and zolpidem significantly reduced anxiety levels and postoperative pain in patients undergoing implant placement.
目的:评价咪达唑仑和唑吡坦对种植体植入术患者术后疼痛感知的影响。材料与方法:在体内研究中，根据制定的纳入标准，选择60例植入体患者，经知情同意后，采用顺序编号、不透明、密封信封(SNOSE)法随机分为3组，每组20例。A组为对照组，B组术前30分钟给予咪达唑仑7.5 mg。C组患者在手术前30分钟给予唑吡坦5 mg。采用Corah量表记录患者的焦虑水平，采用VAS量表记录植入2小时后患者的术后疼痛。统计学分析采用方差分析(ANOVA)、单因素方差分析(single - multivariate analysis of variance, single - MANOVA)，组间比较采用Tukey’s honest Significant Difference (HSD)检验，显著性水平为0.05。结果:A组患者平均焦虑水平为16±1.451,B组患者平均焦虑水平为11.2±2.858,C组患者平均焦虑水平为13±2.9019，组间差异有统计学意义(P < 0.05)。A组术后疼痛感均值为6.8±1.1965,B组为3.8±1.3611,C组为5±1.451，组间差异有统计学意义(P < 0.05)。结论:本研究得出咪达唑仑和唑吡坦均可显著降低种植体植入术患者的焦虑水平和术后疼痛。
{"title":"Effectiveness of Antianxiety Drugs on Postoperative Pain Perception After Implant Placement: An In Vivo Study","authors":"M. Tulsani, D. Ganapathy, D. Rupawat, Sanjana Devi","doi":"10.1177/2320206820981485","DOIUrl":"https://doi.org/10.1177/2320206820981485","url":null,"abstract":"Aim: To evaluate the effectiveness of midazolam and zolpidem on postoperative pain perception in patients undergoing implant placement. Materials and Methods: In the present in vivo study 60 patients undergoing implant placement were selected based on the inclusion criteria framed and were randomly allocated using sequentially numbered, opaque, and sealed envelope (SNOSE) method into 3 groups with 20 patients each after obtaining informed consent. Group A was the control group, Group B received midazolam 7.5 mg 30 minutes before the procedure. Group C received zolpidem 5 mg 30 minutes before the procedure. The anxiety level of patients was recorded using the Corah scale and postoperative pain was recorded after 2 hours of implant placement using the VAS scale. Statistical analysis was done using analysis of variance (ANOVA), one-way multivariate analysis of variance (one-way MANOVA), and then Tukey’s Honestly Significant Difference (HSD) test for comparison among groups at the 0.05 level of significance. Results: Group A had a mean anxiety level of 16 ± 1.451, Group B had a mean anxiety level of 11.2 ± 2.858, and Group C had a mean anxiety level of 13 ± 2.9019 and a statistically significant difference between the groups was observed (P < .05). The mean for the postoperative pain perception for Group A was 6.8 ± 1.1965, for Group B was 3.8 ± 1.3611, and Group C was 5 ± 1.451 and a statistically significant difference between the groups was observed (P < .05). Conclusion: This study concluded that both midazolam and zolpidem significantly reduced anxiety levels and postoperative pain in patients undergoing implant placement.","PeriodicalId":43017,"journal":{"name":"Journal of Advanced Oral Research","volume":"60 1","pages":"144 - 152"},"PeriodicalIF":0.7,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91230480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-01DOI: 10.1177/2320206820977676
Merlin Jayaraj, P. Ramani, H. Sherlin
Background: Keratocystic odontogenic tumor (KCOT) is an odontogenic lesion which manifests distinct biological behavior. Predominant studies in KCOT attribute this behavior to high epithelial proliferative capacity. Besides, a few studies facet loosely arranged collagen can contribute to the behavior of KCOT. Matrix metalloproteinases (MMP) are enzymes that degrade extracellular matrix components under both physiologic and pathologic conditions. The loosely arranged collagen in connective tissue wall of KCOT could be related to the degree of MMP-9 expression. Aim: To evaluate the arrangement of collagen fibers along with immunoexpression of MMP-9 and to relate to its neoplastic biologic behavior in sporadic cases of KCOT. Materials and Methods: KCOT (n = 23) and dentigerous cyst (DC) (n = 15) samples were processed for the following techniques: Masson’s trichrome stain for light microscopy, PMA-PSR stain for confocal microscopy, and MMP-9 for immunohistochemistry. Results: In Masson’s trichrome analysis, correlation of collagen fiber arrangement in the deeper regions with color intensity for KCOT was found to be statistically significant (P = .033). In confocal microscopy, there was no difference between intensities in KCOT (P = .990) and DC (P = .233), respectively. The immunoexpression of MMP-9 in the connective tissue wall of DC (73.3%) was relatively higher than that of KCOT (60.8%). However, on comparison between KCOT and DC in the presence of inflammation, the immunoexpression of MMP-9 was higher in DC (100%) than KCOT (69.9%) and was statistically significant (P = .028). Conclusion: It was concluded that the loose connective tissue wall in KCOT is because of the inherent nature of the lesion that could facilitate its biologic behavior. If inflammation is present, this could further aggravate the tumorigenic behavior.
{"title":"Evaluation of the Connective Tissue Wall in Sporadic Cases of Keratocystic Odontogenic Tumor (KCOT) Using MMP-9 and Confocal Microscopy: A Retrospective Study","authors":"Merlin Jayaraj, P. Ramani, H. Sherlin","doi":"10.1177/2320206820977676","DOIUrl":"https://doi.org/10.1177/2320206820977676","url":null,"abstract":"Background: Keratocystic odontogenic tumor (KCOT) is an odontogenic lesion which manifests distinct biological behavior. Predominant studies in KCOT attribute this behavior to high epithelial proliferative capacity. Besides, a few studies facet loosely arranged collagen can contribute to the behavior of KCOT. Matrix metalloproteinases (MMP) are enzymes that degrade extracellular matrix components under both physiologic and pathologic conditions. The loosely arranged collagen in connective tissue wall of KCOT could be related to the degree of MMP-9 expression. Aim: To evaluate the arrangement of collagen fibers along with immunoexpression of MMP-9 and to relate to its neoplastic biologic behavior in sporadic cases of KCOT. Materials and Methods: KCOT (n = 23) and dentigerous cyst (DC) (n = 15) samples were processed for the following techniques: Masson’s trichrome stain for light microscopy, PMA-PSR stain for confocal microscopy, and MMP-9 for immunohistochemistry. Results: In Masson’s trichrome analysis, correlation of collagen fiber arrangement in the deeper regions with color intensity for KCOT was found to be statistically significant (P = .033). In confocal microscopy, there was no difference between intensities in KCOT (P = .990) and DC (P = .233), respectively. The immunoexpression of MMP-9 in the connective tissue wall of DC (73.3%) was relatively higher than that of KCOT (60.8%). However, on comparison between KCOT and DC in the presence of inflammation, the immunoexpression of MMP-9 was higher in DC (100%) than KCOT (69.9%) and was statistically significant (P = .028). Conclusion: It was concluded that the loose connective tissue wall in KCOT is because of the inherent nature of the lesion that could facilitate its biologic behavior. If inflammation is present, this could further aggravate the tumorigenic behavior.","PeriodicalId":43017,"journal":{"name":"Journal of Advanced Oral Research","volume":"69 1","pages":"134 - 143"},"PeriodicalIF":0.7,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83025492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-20DOI: 10.1177/23202068211006554
Deniz Erdil, N. Bağiş, H. Eren, Melike Camgoz, K. Orhan
Aim: Bruxism is defined as the involuntary recurrent masticatory muscle activity characterized by gnashing, grinding, clenching of teeth, and/or pushing the mandible. Factors creating its etiology are peripheral (morphological) or central (physiopathological and physiological), and exogenous. Recently, among physiological factors, depression and bruxism were considered to be related. A definitive treatment method does not exist for bruxism; however, botulinum toxin-A (BT-A) application is an up-to-date and effective way of treatment. The present study is aimed to evaluate the levels of depression in bruxism patients treated with BT-A application. Materials and Methods: A total of 25 individuals (23 females and 2 males) who were diagnosed as bruxism patients were included in the study. 25 U of BT-A for each masseter muscle was injected into the patients. Patients were prospectively observed for a possible change in depression levels by using Beck’s Depression Inventory. The inventory was implemented before and six months after the BT-A application. Depression levels before and six months after the injection were compared. A paired t-test was used to compare “before” and “after” treatment values. One-way analysis of variance and post-hoc Tukey tests were used to evaluate the change in Beck’s Depression Inventory scores according to age groups. Results: The mean total score was 7.80 ± 8.10 before the treatment and 7.16 ± 6.52 six months after the treatment. The decrease in the mean score was not statistically significant (P > .05). Conclusion: In conclusion, despite the decrease in the mean Beck’s Depression Inventory scores, a statistically significant decrease in the depression levels of patients was not observed.
目的:磨牙症是指以咬合、磨牙、咬牙和/或推动下颌骨为特征的咀嚼肌不自主复发性活动。造成其病因的因素是外周(形态学)或中枢(生理、病理和生理)和外源性的。近年来，在生理因素中，抑郁症和磨牙症被认为是相关的。磨牙症没有明确的治疗方法;然而，肉毒杆菌毒素a (BT-A)的应用是一种最新和有效的治疗方法。本研究旨在评估磨牙患者应用BT-A治疗后的抑郁水平。材料与方法:共纳入25例确诊为磨牙症患者，其中女性23例，男性2例。每条咬肌注射25 U BT-A。采用贝克抑郁量表前瞻性地观察患者抑郁水平的可能变化。该清单是在BT-A申请之前和之后六个月实施的。比较注射前和注射后6个月的抑郁水平。配对t检验用于比较“治疗前”和“治疗后”的值。采用单因素方差分析和事后Tukey检验来评估贝克抑郁量表得分在不同年龄组中的变化。结果:治疗前平均总分为7.80±8.10分，治疗6个月后平均总分为7.16±6.52分。平均评分下降无统计学意义(P > 0.05)。结论:综上所述，尽管贝克抑郁量表的平均得分有所下降，但患者的抑郁水平并未出现统计学上的显著下降。
{"title":"Evaluation of Changes in Depression Levels of Bruxism Patients Treated With Botulinum Toxin-A","authors":"Deniz Erdil, N. Bağiş, H. Eren, Melike Camgoz, K. Orhan","doi":"10.1177/23202068211006554","DOIUrl":"https://doi.org/10.1177/23202068211006554","url":null,"abstract":"Aim: Bruxism is defined as the involuntary recurrent masticatory muscle activity characterized by gnashing, grinding, clenching of teeth, and/or pushing the mandible. Factors creating its etiology are peripheral (morphological) or central (physiopathological and physiological), and exogenous. Recently, among physiological factors, depression and bruxism were considered to be related. A definitive treatment method does not exist for bruxism; however, botulinum toxin-A (BT-A) application is an up-to-date and effective way of treatment. The present study is aimed to evaluate the levels of depression in bruxism patients treated with BT-A application. Materials and Methods: A total of 25 individuals (23 females and 2 males) who were diagnosed as bruxism patients were included in the study. 25 U of BT-A for each masseter muscle was injected into the patients. Patients were prospectively observed for a possible change in depression levels by using Beck’s Depression Inventory. The inventory was implemented before and six months after the BT-A application. Depression levels before and six months after the injection were compared. A paired t-test was used to compare “before” and “after” treatment values. One-way analysis of variance and post-hoc Tukey tests were used to evaluate the change in Beck’s Depression Inventory scores according to age groups. Results: The mean total score was 7.80 ± 8.10 before the treatment and 7.16 ± 6.52 six months after the treatment. The decrease in the mean score was not statistically significant (P > .05). Conclusion: In conclusion, despite the decrease in the mean Beck’s Depression Inventory scores, a statistically significant decrease in the depression levels of patients was not observed.","PeriodicalId":43017,"journal":{"name":"Journal of Advanced Oral Research","volume":"48 1","pages":"200 - 205"},"PeriodicalIF":0.7,"publicationDate":"2021-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76013598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-04DOI: 10.1177/23202068211005611
K. Orhan, G. Yazici, M. Kolsuz, N. Kafa, I. Bayrakdar, Özer Çelik
Aim: The present study is aimed to assess the segmentation success of an artificial intelligence (AI) system based on the deep convolutional neural network (D-CNN) method for the segmentation of masseter muscles on ultrasonography (USG) images. Materials and Methods: This retrospective study was carried out by using the radiology archive of the Department of Oral and Maxillofacial Radiology of the Faculty of Dentistry in Ankara University. A total of 195 anonymized USG images were used in this retrospective study. The deep learning process was performed using U-net, Pyramid Scene Parsing Network (PSPNet), and Fuzzy Petri Net (FPN) architectures. Muscle thickness was assessed using USG by manual segmentation and measurements using USG’s software. The neural network model (CranioCatch, Eskisehir-Turkey) was then used to determine the muscles, following automatic measurements of the muscles. Accuracy, ROC area under the curve (AUC), and Precision-Recall Curves (PRC) AUC were calculated in the test dataset and compare a human observer and the AI model. Manual segmentation and measurements were compared statistically with AI (P < .05). The Mann–Whitney U test was used to analyze whether there is a statistically significant difference between the predicted values and the actual values. Results: The AI models detected and segmented all test muscle data for FPN and U-net, while only two cases of muscles were not detected by PSPNet (false negatives). Accuracies of FPN, PSPNet, and U-net were estimated as 0.985, 0.947, and 0.969, respectively. Receiver operating characteristic scores of FPN, PSPNet, and U-net were estimated as 0.977, 0.934, and 0.969, respectively. The D-CNN measurements of the muscles were similar to manual measurements. There was no significant difference between the two measurement methods in three groups (P > .05). Conclusion: The proposed AI system approach for the analysis of USG images seems to be promising for automatic masseter muscle segmentation and measurement of thickness. This method can help surgeons, radiologists, and other professionals such as physical therapists in evaluating the time correctly and saving time for diagnosis.
{"title":"An Artificial Intelligence Hypothetical Approach for Masseter Muscle Segmentation on Ultrasonography in Patients With Bruxism","authors":"K. Orhan, G. Yazici, M. Kolsuz, N. Kafa, I. Bayrakdar, Özer Çelik","doi":"10.1177/23202068211005611","DOIUrl":"https://doi.org/10.1177/23202068211005611","url":null,"abstract":"Aim: The present study is aimed to assess the segmentation success of an artificial intelligence (AI) system based on the deep convolutional neural network (D-CNN) method for the segmentation of masseter muscles on ultrasonography (USG) images. Materials and Methods: This retrospective study was carried out by using the radiology archive of the Department of Oral and Maxillofacial Radiology of the Faculty of Dentistry in Ankara University. A total of 195 anonymized USG images were used in this retrospective study. The deep learning process was performed using U-net, Pyramid Scene Parsing Network (PSPNet), and Fuzzy Petri Net (FPN) architectures. Muscle thickness was assessed using USG by manual segmentation and measurements using USG’s software. The neural network model (CranioCatch, Eskisehir-Turkey) was then used to determine the muscles, following automatic measurements of the muscles. Accuracy, ROC area under the curve (AUC), and Precision-Recall Curves (PRC) AUC were calculated in the test dataset and compare a human observer and the AI model. Manual segmentation and measurements were compared statistically with AI (P < .05). The Mann–Whitney U test was used to analyze whether there is a statistically significant difference between the predicted values and the actual values. Results: The AI models detected and segmented all test muscle data for FPN and U-net, while only two cases of muscles were not detected by PSPNet (false negatives). Accuracies of FPN, PSPNet, and U-net were estimated as 0.985, 0.947, and 0.969, respectively. Receiver operating characteristic scores of FPN, PSPNet, and U-net were estimated as 0.977, 0.934, and 0.969, respectively. The D-CNN measurements of the muscles were similar to manual measurements. There was no significant difference between the two measurement methods in three groups (P > .05). Conclusion: The proposed AI system approach for the analysis of USG images seems to be promising for automatic masseter muscle segmentation and measurement of thickness. This method can help surgeons, radiologists, and other professionals such as physical therapists in evaluating the time correctly and saving time for diagnosis.","PeriodicalId":43017,"journal":{"name":"Journal of Advanced Oral Research","volume":"52 1","pages":"206 - 213"},"PeriodicalIF":0.7,"publicationDate":"2021-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85853255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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