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Response: The Risk Factors of Sarcopenia among Korean Elderly Men: Based on 2009 Korean National Health and Nutrition Examination Survey Data (Korean J Obes 2014;23:23-31) 韩国老年男性肌肉减少症的危险因素分析——基于2009年韩国国民健康与营养调查数据(Korean J obe 2014;23:23-31)
Pub Date : 2014-06-01 DOI: 10.7570/KJO.2014.23.2.139
Sang Kyo Lee, J. A. Lee, Jin Young Kim, Young Zu Kim, H. Park
러한 관련성으로 인해 근감소증이 있는 노인에서는 사망률이 증가한 다고 알려져 있다. 근감소증에 대한 정의는 다양하며 여러 측정법과 측정지표를 사용하여 제시되고 있다. 보편적으로 사용되는 근감소증 의 임상적인 정의는 Baumgartner 등에 의해 1989년 제시된 것으로, 이중에너지방사선흡수계측기(DEXA)로 측정한 양측 상하지 근육량 의 합(appendicular skeletal mass)을 신장의 제곱으로 나눈 값으로 skeletal muscle index (SMI)를 계산하였으며, 이 값이 건강한 젊은 성 인의 평균값과 비교하여 2 표준편차 이하로 감소한 경우를 근감소증 으로 정의하였다. 또한 Janssen 등은 총 근육량(SMI)을 체중(Wt)으 로 나눈 지수(SMI= SM×100/Wt)로 근감소증을 정의하였다. 본 연구에서는 Baumgartner의 정의를 사용하여 근감소증을 정의 하였고, 이러한 근감소증의 위험은 저체중군에서 매우 증가하는 것 으로 나타났다. 독자투고에서 언급한 비만의 역설은 65세 이상의 노인에서 비만이 수명 연장에 미치는 효과가 중립적이거나 이익이 된다는 보고들에서 나온 개념이다. 이는 심혈관 질환의 발생이 비만 및 과체중과 관련이 깊은데 반해, 여러 연구들에서 심혈관 질환으로 인한 사망률 혹은 총
由于这种关联,患有肌肉减少症的老人的死亡率会增加。肌减症的定义是多种多样的,使用了多种测定方法和测定指标。1989年,Baumgartner等人提出了双能量辐射吸收器(DEXA)测量的双侧上下肌量之和(appendicular skeletal mass)除以肾脏平方得出的skeletal muscle index (SMI)。与健康的年轻成年人的平均值相比,这一数值减少到2个标准偏差以下的情况被定义为肌减症。此外,Janssen等人用总肌肉量(SMI)除以体重(Wt)的指数(SMI= SM×100/Wt)定义了肌肉减少症。本研究使用Baumgartner的定义来定义肌减症,而这种肌减症的风险在低体重群体中会显著增加。读者投稿中提到的“肥胖悖论”是从“对65岁以上老人来说,肥胖对延长寿命的效果是中立的或有利的”报告中产生的概念。心血管疾病的发生与肥胖和超重有很大的关系,但许多研究表明心血管疾病的死亡率或总死亡率
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引用次数: 0
Comparison of Obesity and Overweight Prevalence Among Korean Adults According to Community Health Survey and Korea National Health and Nutrition Examination Survey 根据社区健康调查和韩国国家健康和营养检查调查,韩国成年人肥胖和超重患病率的比较
Pub Date : 2014-03-01 DOI: 10.7570/KJO.2014.23.1.64
Y. Park, Y. Cho, J. Kang, H. A. Park, K. Kim, Yang-Im Hur, J. Seo, N. Park
Background: The prevalence of obesity was estimated based on self-reported height and weight recorded in the Community Health Survey (CHS), a nationwide survey which began in 2008. This study was conducted to evaluate the extent and consistency of underestimation in obesity and overweight prevalences in CHS compared to the Korea National Health and Nutrition Examination Survey (KNHANES) data. Methods: In this study, we compared the prevalence estimates of obesity and overweight among Korean adults aged 20 and over using 2010 KNHANES and 2010 CHS data. In contrast to KNHANES data, where subjects' height and weight were actually measured, CHS data relied on subjects' self-reported height and weight. Results: Compared to KNHANES, CHS underestimated the obesity and overweight prevalence by 8.6%P and 7.8%P, respectively. Height (men: -0.9 cm, women: -1.7 cm) was overestimated while weight (men: 0.5 kg, women: 1.1 kg) and body mass index (men: 0.4 kg/m, women: 1.0 kg/m) were underestimated in CHS compared to KNHANES data. The overestimation of height was greater as age increased and weight was underestimated by more than 1.0 kg among men
背景:肥胖的流行程度是根据社区健康调查(CHS)中记录的自我报告的身高和体重来估计的,这是一项始于2008年的全国性调查。本研究旨在评估与韩国国家健康与营养调查(KNHANES)数据相比,CHS中肥胖和超重患病率低估的程度和一致性。方法:在本研究中,我们使用2010年KNHANES和2010年CHS数据比较了20岁及以上韩国成年人的肥胖和超重患病率估计。KNHANES的数据是实际测量受试者的身高和体重,而CHS的数据依赖于受试者自我报告的身高和体重。结果:与KNHANES相比,CHS分别低估了8.6%P和7.8%P的肥胖和超重患病率。与KNHANES数据相比,CHS的身高(男性:-0.9 cm,女性:-1.7 cm)被高估,而体重(男性:0.5 kg,女性:1.1 kg)和体重指数(男性:0.4 kg/m,女性:1.0 kg/m)被低估。随着年龄的增长,对身高的高估越大,而对体重的低估则超过1.0公斤
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引用次数: 14
The Risk Factors of Sarcopenia among Korean Elderly Men : Based on 2009 Korean National Health and Nutrition Examination Survey Data 韩国老年男性肌肉减少症的危险因素:基于2009年韩国国民健康与营养调查数据
Pub Date : 2014-03-01 DOI: 10.7570/KJO.2014.23.1.23
Sang Kyo Lee, J. A. Lee, Jin Young Kim, Young Zu Kim, H. Park
Background: Sarcopenia, the loss of muscle mass, is an important health problem that is increasing with age. However, little is known about the risk factors of sarcopenia. The purpose of this study was to evaluate the risk factors for sarcopenia in elderly Korean men using data from the 2009 Korean National Health and Nutrition Examination Survey (KNHANES). Methods: We used KNHANES data including 691 men above the age of 60. In this study, sarcopenia was defined as aLM (appendicular lean mass) / height 2 ± 2SD or more below the normal mean for young. Chi-square test and logistic regression analysis were performed to evaluate the factors associated with sarcopenia including age, marital status, income, cigarette smoking, alcohol, physical activity, and caloric intake. Results: In our study population, 11.6% of the men had sarcopenia. The mean aLM/height 2 in men was 6.1 kg/m in subjects with sarcopenia and 7.8 kg/m 2 in subjects without sarcopenia, respectively. Subjects with sarcopenia tended to be older with lower BMI, and lower energy intake. Also, lower educational level and divorced/widowed status were factors associated with sarcopenia. In multivariate logistic regression analysis, old age, low BMI, and low caloric intake were associated with sarcopenia. Conclusion: Older age, lower BMI, and lower daily calorie intake were the risk factors for sarcopenia among Korean men over the age of 60. Therefore, an appropriate
背景:肌肉减少症是一种重要的健康问题,随着年龄的增长而增加。然而,对肌肉减少症的危险因素知之甚少。本研究的目的是利用2009年韩国国家健康与营养检查调查(KNHANES)的数据,评估韩国老年男性肌肉减少症的危险因素。方法:我们使用KNHANES数据,包括691名60岁以上的男性。在本研究中,肌肉减少症被定义为aLM(阑尾瘦质量)/身高低于正常平均值2±2SD或更多。采用卡方检验和logistic回归分析来评价与肌肉减少症相关的因素,包括年龄、婚姻状况、收入、吸烟、饮酒、体育活动和热量摄入。结果:在我们的研究人群中,11.6%的男性患有肌肉减少症。男性肌肉减少症患者的平均身高为6.1 kg/m,非肌肉减少症患者的平均身高为7.8 kg/m。肌肉减少症患者往往年龄较大,身体质量指数较低,能量摄入较低。此外,低教育水平和离婚/丧偶状况也是肌肉减少症的相关因素。在多变量logistic回归分析中,老年、低BMI和低热量摄入与肌肉减少症相关。结论:年龄较大、BMI较低、每日热量摄入较低是韩国60岁以上男性肌肉减少症的危险因素。因此,适当的
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引用次数: 12
Evaluation of Dietary Intake and Exercise in the Elderly According to Hand Grip Strength 根据握力评价老年人膳食摄入与运动
Pub Date : 2013-12-31 DOI: 10.7570/KJO.2013.22.4.243
Jaekyung No
Background: The prevalence of chronic disease is increased by sarcopenia, which is change in body composition induced by aging resulting in loss of muscle mass and increase in fat mass. The purpose of this study was to identify any difference between dietary habits, patterns of snacking, and exercise between elderly subjects with normal and abnormal hand grip strength. Methods: A cross sectional study of 135 elderly members from a senior welfare center was carried out and data were collected through interviews by using a structured questionnaire which included factors such as education level, BMI, dietary habit, pattern of snacking, and exercise associated with hand grip strength. The subjects were classified into abnormal and normal groups based on hand grip strength. Results: The results showed significant differences in education level, age, and BMI among the two groups. Subjects among the normal hand grip strength group showed greater frequency in food intake and snacking than in the abnormal group. They also showed, although not statistically significant, higher intake of food and snacks containing calcium, vitamin D-rich dairy, legumes, and eggs while they scored lower in resistance exercise. Conclusion: The results indicate that in order to increase muscle strength in the elderly, it is necessary to prevent being underweight by proper dietary habit, and exercise.
背景:骨骼肌减少症是由衰老引起的身体成分变化,导致肌肉量减少和脂肪量增加,慢性疾病的患病率增加。本研究的目的是确定饮食习惯、零食模式和运动之间的差异,这些差异存在于手部握力正常和异常的老年受试者之间。方法:对某老年福利院135名老年会员进行横断面调查,采用结构化问卷访谈法收集数据,问卷内容包括受教育程度、身体质量指数、饮食习惯、零食习惯、手部握力运动等因素。根据手部握力将受试者分为异常组和正常组。结果:两组患者的受教育程度、年龄、BMI均有显著差异。握力正常组的受试者比握力异常组的受试者进食和吃零食的频率更高。他们还发现,尽管在统计数据上不显著,但摄入含钙食物和零食、富含维生素d的乳制品、豆类和鸡蛋的人,在抗阻运动中得分较低。结论:为提高老年人肌肉力量,应通过合理的饮食习惯和运动预防体重过轻。
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引用次数: 6
A Case of Bilateral ACTH-independent Adrenal Adenomas with Cushing's Syndrome Treated by Ipsilateral Total and Contralateral Partial Laparoscopic Adrenalectomy 双侧acth非依赖性肾上腺腺瘤伴库欣综合征1例经同侧和对侧腹腔镜肾上腺部分切除术治疗
Pub Date : 2013-12-31 DOI: 10.7570/KJO.2013.22.4.254
S. Park, D. Jung, Soon-Young Kim, N. Choi, Tae-Jun Kim, Yong kyun Kim, S. Na, C. Kim, Seong-Jin Lee, S. Ihm, J. Kang
ACTH-independent Cushing syndrome, which is mainly caused by a unilateral adrenal adenoma or adrenal carcinoma, account for 15~20% of Cushing’s syndrome. Cushing’s syndrome caused by bilateral adrenal masses is rare, including bilateral adrenal adenomas or carcinomas (AIMAH and PPNAD). Adrenal adenoma is commonly treated by Laparoscopic total adrenalectomy. However, bilateral total adrenalectomy causes acute adrenal insufficiency (Addisonian crisis), requiring lifelong steroid replacement. We present a young female patient with bilateral adrenocortical adenoma causing Cushing’s syndrome who was completely cured by successful laparoscopic total & partial adrenalectomy. Primarily we decided to remove the right adrenal gland to preserve the residual function of the left adrenal gland. However, after right total adrenalectomy, the patient manifested symptoms of subclinical Cushing syndrome including hypertension, truncal obesity, diabetes, low HDL cholesterol, and elevated triglycerides. Subsequently the patient underwent partial left adrenal mass excision, preserving the normal portion of the adrenal gland. The patient thereafter achieved biochemical resolution and significant improvement of hypertension, obesity, and diabetes without the need of any medication.
acth非依赖性库欣综合征占库欣综合征的15~20%,主要由单侧肾上腺腺瘤或肾上腺癌引起。由双侧肾上腺肿块引起的库欣综合征是罕见的,包括双侧肾上腺腺瘤或癌(AIMAH和PPNAD)。肾上腺腺瘤通常采用腹腔镜全肾上腺切除术治疗。然而,双侧肾上腺全切除术会导致急性肾上腺功能不全(addison危机),需要终生更换类固醇。我们报告一例年轻女性双侧肾上腺皮质腺瘤引起的库欣综合征,经腹腔镜肾上腺全、部分切除术成功治愈。首先,我们决定切除右肾上腺以保留左肾上腺的残余功能。然而,在右侧肾上腺全切除术后,患者表现出亚临床库欣综合征的症状,包括高血压、躯干肥胖、糖尿病、低HDL胆固醇和甘油三酯升高。随后,患者接受了左侧肾上腺肿块部分切除,保留了肾上腺的正常部分。此后,患者在不需要任何药物的情况下,实现了高血压、肥胖和糖尿病的生化解决和显著改善。
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引用次数: 0
Relationship between obesity indices and cardiovascular risk score in Korean type 2 diabetes patients 韩国2型糖尿病患者肥胖指数与心血管危险评分的关系
Pub Date : 2013-09-30 DOI: 10.7570/KJO.2013.22.3.148
S. Yoo, Miyeon Kim, Suhee Kim, Sung Hyun Kim, Seong Joo Ko, J. Beom, Ji young Kim, J. Jo, Yung Uck Kim, Dahee Heo, J. Moon, Shinhang Moon, Yung Hyup Lim, Sang Ah Lee, D. Lee, Dong-Mee Lim, Keun-Young Park, B. Kim, G. Koh
So Yeon Yoo, Miyeon Kim, Suhee Kim, Sung Hyun Kim, Seong Joo Ko, Jong Wook Beom, Ji Young Kim, Jaemin Jo, Yung Uck Kim, Dahee Heo, Jae cheol Moon, Shinhang Moon, Yung Hyup Lim, Sang Ah Lee , Dae-Ho Lee, Dong Mee Lim, Keun Young Park, Byung-Joon Kim, Gwanpyo Koh Department of Internal Medicine, Jeju National University Hospital; Department of Internal Medicine, Jeju National University School of Medicine ; Department of Nephrology, Asan Medical Cencer; Department of Endocrinology & Metabolism, Wonkwang University Hospital; Department of Endocrinology & Metabolism, Konyang University Hospital; and Department of Endocrinology & Metabolism, Gachon University Gil Medical Center
柳素妍、金美妍、金秀姬、金成贤、高成珠、范钟旭、金智英、赵在民、金永旭、许大熙、文在哲、文新行、林容协、李相娥、李大镐、林东美、朴根英、金炳俊、高宽杓国立济州大学医学院内科教研室;峨山医院肾内科;圆光大学医院内分泌代谢科;锦阳大学附属医院内分泌代谢科;加川大学吉尔医学中心内分泌代谢科
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引用次数: 7
Bone Health and Calcium, Vitamin D, Potassium: Shortfall Nutrients in Korean 骨骼健康与钙、维生素D、钾:韩国人缺乏营养
Pub Date : 2013-09-01 DOI: 10.7570/KJO.2013.22.3.129
Mi-Ja Choi
골다공증과 골절은 고령화로 전 세계적으로 증가될 전망이 다. 골다공증으로 인한 골절은 장기간 불편과 삶의 질 저하 및 의료비와 사망률을 증가시키는데, 골다공증의 예방과 치료를 통하여 골절의 위험을 낮출 수 있다. 골 건강에 영향을 미치는 인자는 유전, 신체활동, 적당한 영양 등이 있으며, 영양은 청소 년기에 최대골함량 및 최대골밀도 형성과 노년기에 골감소 지 연에 중요한 역할을 한다. 따라서 골 건강을 위하여 균형 잡힌 영양소 공급은 필수적이며 특히 칼슘과 비타민 D의 충분한 섭 취는 골 건강 유지와 골다공증 위험을 낮추기 위하여 평생 동 안 중요하다고 알려져 있다. 그러나 한국인은 일일 평균 칼슘 섭취량은 권장섭취량 보다 매우 낮게 섭취하고 있고, 혈중 비 타민 D 농도가 20 ng/mL 이상을 충분으로 볼 때 비타민 D는 부족하다. 2010년 한국인 영양섭취기준에서 1~18세의 비타민 D 일일 충분섭취량은 5 μg으로 책정되어있으나 청소년기의 최대골밀도 형성을 위하여 상향 조정을 고려 해 볼 수 있다고 보여지고, 50세 이상의 경우에서도 칼슘 권장섭취량은 700 mg, 비타민 D 충분섭취량은 10 μg을 추천하고 있으나 골감소 지연을 위하여 칼슘과 비타민 D 영양섭취기준치를 상향 조정 할 필요가 있다고 보여진다. 또한 칼슘과 비타민 D 외 다른 영 양소의 섭취도 골건강을 위하여 중요한데 한국인의 연령대별 일일 평균 칼륨의 섭취도 충분섭취량 보다 낮게 섭취하고 있 다. 과일과 채소는 칼륨과 다른 영양소의 섭취에서 중요하다. 사람은 각각 분리된 영양소를 섭취하는 것이 아니라 여러 가 지 영양소가 복합적으로 포함되어 있는 식품을 통하여 영양소 를 섭취하므로 이를 고려하여 단일 영양소의 기능 외 전체식 품, 식이패턴, 식사의 질, 영양소 간의 비율 등과 골대사 및 골 절의 관계에 대한 연구가 더 이루어져야 할 것이다.
骨质疏松症和骨折因老龄化预计将在全世界范围内增加。骨质疏松症引起的骨折会长期带来不便,生活质量低下,增加医疗费和死亡率,通过骨质疏松症的预防和治疗可以降低骨折的危险。影响骨质健康的因子有遗传、身体活动、适当营养等,营养在青少年时期对最大骨含量及最大骨密度的形成和老年期减少骨的延髓起重要作用。因此,为了骨骼健康,均衡的营养素供给是必需的,特别是钙和维生素D的充分摄取量,对维持骨骼健康和降低骨质疏松症的危险非常重要。但是,韩国人每天的平均钙摄取量比建议摄取量要低得多,如果血液中维他明D浓度达到20 ng/mL以上,维生素D是不足的。2010年韩国人营养摄取标准中,1~18岁的维生素D日充分摄取量定为5 μg,但为了形成青少年时期最大的骨密度,可以考虑向上调整。50岁以上的人也建议钙摄取量为700毫克;维生素D的充分摄取量推荐为10 μg,但为了推迟骨质减少,有必要上调钙和维生素D营养摄取标准值。另外,除了钙和维生素D以外,摄取其他营养素对骨骼健康也很重要,韩国人各年龄段的日均钾摄取量也低于充分摄取量。水果和蔬菜对摄取钾和其他营养素很重要。人分别分离营养素摄取的,而是多种营养素包括综合是通过食品营养素摄取,因此考虑单一营养素功能外,整个仪式品、膳食模式的饮食质量,营养素之间的比例等和骨代谢及节对关系的研究还需要组成的。
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引用次数: 8
An Analysis of Research on the Impact of School-Based Physical Education for Preventing Students' Obesity: Systematic Review and Meta Analysis 校本体育对预防学生肥胖影响的研究分析:系统评价与Meta分析
Pub Date : 2013-09-01 DOI: 10.7570/KJO.2013.22.3.167
Ook-sang Cho, Sumi Cho
초·중등학교 학생들의 비만비율은 빠른 속도로 증가하고 있고 관련 통계수치는 이미 위험 수준에 도달해 있다. 교육 과학기술부가 2006년부터 2008년까지 전국 468개교, 11 만 2천명을 대상으로 실시한 학교건강검사의 결과에 따르 면, 초·중·고등학교 학생들의 전체 비만비율은 11.2%에 달 했고 이 통계수치는 3년간 거의 변화가 없었다. 서구사회의 학생비만 현상 역시 심각한 사회문제로 대두되고 있다. 1980년 이후 미국의 아동과 청소년의 과체중 비율은 2배, 학교체육이 학생들의 비만에 미치는 영향: 체계적 문헌고찰 및 메타분석 An Analysis of Research on the Impact of School-Based Physical Education for Preventing Students' Obesity: Systematic Review and Meta Analysis
中小学学生的肥胖比例正在快速增加,相关统计数据已经达到危险水平。教育科学技术部从2006年到2008年以全国468所学校的11万2千名学生为对象进行的学校健康检查结果显示,小学、初中、高中学生的整体肥胖比率达到11.2%,这一统计数据在3年间几乎没有变化。西欧社会的学生肥胖现象也正在成为严重的社会问题。1980年以来,美国儿童和青少年的超重比例为两倍,学校体育对学生肥胖的影响:系统文献研究及元分析。以学校为基础的Physical Education for Preventing Students' Obesity:Systematic Review and Meta Analysis
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引用次数: 4
Risk Factors for Gestational Diabetes Mellitus in Korean Women 韩国妇女妊娠期糖尿病的危险因素
Pub Date : 2013-06-30 DOI: 10.7570/KJO.2013.22.2.85
M. Kim, Sang Kyo Lee, J. A. Lee, P. Lee, H. Park
Background: Gestational diabetes mellitus (GDM) increases the risk of perinatal complications and the possibility of progressing to overt diabetes mellitus and obesity in mothers. The purpose of this study was to determine the risk factors associated with the development of GDM, and to evaluate the effect of GDM in perinatal outcome. Method: We retrospectively reviewed the medical records of 1,161 mothers and their neonates, both whom had received antenatal care in a tertiary hospital between Jan 2006 and Nov 2011. The risk factors associated with the development of GDM were evaluated by multiple logistic regression. Results: The prevalence of GDM in this study was 4.1%. The frequency of a larger-than-normal fetus for its gestational age was 14.6% in GDM mothers, which was higher than 3.8% in normal mothers. The odds ratio (OR) of having GDM was significantly higher in those with a family history of DM (OR 2.26 [95% CI 1.15~4.43]) than in those without. In addition, the OR of having GDM tended to increase according to increments of BMI levels before pregnancy: OR of 2.13 (95% CI 0.99~4.61), 3.83 (95% CI 1.65~8.90), 4.04(95% CI 1.63~10.06) in mothers with pre-pregnancy BMI levels of 21~23 kg/m , 23~25 kg/m, > 25 kg/m, respectively, when compared to those with BMI < 21 kg/m. Conclusions: Family history of DM, and a high BMI level before pregnancy were shown as risk factors for developing GDM in Korean women. Mothers with family history of DM, and with overweight or obesity should be recognized for their risk of GDM.
背景:妊娠期糖尿病(GDM)增加了围产期并发症的风险,并增加了母亲进展为显性糖尿病和肥胖的可能性。本研究的目的是确定与GDM发生相关的危险因素,并评估GDM对围产期结局的影响。方法:回顾性分析2006年1月至2011年11月在某三级医院接受产前护理的1161名母亲及其新生儿的医疗记录。采用多元logistic回归分析与GDM发生相关的危险因素。结果:本组GDM患病率为4.1%。GDM母亲的胎龄大于正常胎儿的发生率为14.6%,高于正常母亲的3.8%。有糖尿病家族史者患GDM的比值比(OR)显著高于无糖尿病家族史者(OR 2.26 [95% CI 1.15~4.43])。此外,妊娠前BMI水平的增加有增加GDM的OR的趋势:与BMI < 21 kg/m的母亲相比,孕前BMI为21~23 kg/m、23~25 kg/m、bb ~25 kg/m的母亲的OR分别为2.13 (95% CI 0.99~4.61)、3.83 (95% CI 1.65~8.90)、4.04(95% CI 1.63~10.06)。结论:糖尿病家族史和孕前高BMI水平是韩国女性发生GDM的危险因素。有糖尿病家族史的母亲,以及超重或肥胖的母亲,应该认识到她们患糖尿病的风险。
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引用次数: 4
Obesity and High-density lipoprotein Cholesterol (HDL-C) : The Recent Related Research Trend Including New Generation Drugs for HDL-C 肥胖与高密度脂蛋白胆固醇(HDL-C):包括新一代HDL-C药物在内的近期相关研究趋势
Pub Date : 2013-06-01 DOI: 10.7570/KJO.2013.22.2.67
Jongwoo Kim, S. Lee
Low levels of high-density lipoprotein cholesterol (HDL-C) are associated with the development of cardiovascular disease (CVD). In addition, under the state of obesity, HDL particles can be modified to generate dysfunctional HDL-C which is a more important risk factor for CVD. Despite strong evidence of the protective effect of HDL-C to CVD, there are no potent HDL elevators available. However, new insights in HDL biology have recently allowed the development of promising actions aimed to enhance HDL function and promote atherogenesis regression in obesity. Growing burdens of HDL-C action and new generation agents which are thought to be able to raise HDL-C or enhance its function are discussed in this review.
低水平的高密度脂蛋白胆固醇(HDL-C)与心血管疾病(CVD)的发生有关。此外,在肥胖状态下,HDL颗粒可以被修饰,产生功能失调的HDL- c,这是CVD更重要的危险因素。尽管有强有力的证据表明HDL- c对CVD有保护作用,但目前还没有有效的HDL升降机。然而,高密度脂蛋白生物学的新见解最近允许开发有希望的行动,旨在增强高密度脂蛋白功能和促进肥胖的动脉粥样硬化消退。本文就HDL-C作用日益增加的负担和新一代被认为能够提高HDL-C或增强其功能的药物进行综述。
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引用次数: 0
期刊
The Korean Journal of Obesity
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