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Overtreatment: Violating the normative rules of beneficence and nonmaleficence? 过度治疗:违反善意与非恶意的规范规则?
IF 2.1 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2023-02-01 DOI: 10.1016/j.ejwf.2023.01.001
Vinod Krishnan
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引用次数: 0
Orthodontic pain: c-Fos expression in rat brain nuclei after rapid maxillary expansion 正畸疼痛:上颌快速扩张后大鼠脑核c-Fos表达
IF 2.1 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2023-02-01 DOI: 10.1016/j.ejwf.2022.09.003
Caio Luiz Bitencourt Reis , Elaine Machado Pingueiro-Okada , Kelly Galisteu Luiz , Gabriela Leite Pedroso , Mirian Aiko Nakame Matsumoto , Luciane Macedo de Menezes , Erika Calvano Küchler , Glauce Crivelaro Nascimento , Maria Bernadete Sasso Stuani

Background

The aim of this in vivo study was to quantitatively evaluate pain after rapid maxillary expansion (RME) in young rats by analyzing the activation of nociception-related structures, that is, the caudalis, interpolaris, and oralis subnuclei, according to the Fos expression.

Methods

A total of 65 Wistar rats were assigned to three groups: control group (n = 15) with no treatment, positive control group (n = 25), and experimental group (n = 25) with RME. The experimental animals were euthanized at 6, 12, 24, 48, and 72 hours after RME, and the brain was later carefully collected. Coronal sections through the spinal trigeminal caudalis, spinal trigeminal interpolaris, and spinal trigeminal oralis were cut (thickness of 40 µm) on a cryostat and processed for Fos immunohistochemistry. Images from the sections were captured under light microscopy, and ImageJ software was used to count Fos-like immunoreactive neurons. The Analysis of variance (ANOVA) and Tukey test were used for statistical analysis, and the significance level was set at 5%.

Results

RME induced incisor distalization and opening of the midpalatal suture, as well as neuronal activation of the spinal trigeminal nucleus. The experimental group demonstrated significantly more Fos-positive neurons in subnuclei caudalis and subnuclei interpolaris 6 hours after the maxillary expansion. The Fos immunoreactivity significantly decreased at 12 hours and increased again at 24 and 48 hours (P < 0.001).

Conclusions

The RME increases the neural activation of brain regions involved in the nociception region, as determined by the Fos expression. The most intense Fos-like immunoreactive expression was detected in the brain 6 hours after the start of the palatal expansion.

本研究的目的是根据Fos的表达,通过分析伤害感受相关结构,即尾状核、拉里间核和口腔亚核的激活,定量评估年轻大鼠上颌骨快速扩张(RME)后的疼痛。方法将65只Wistar大鼠随机分为三组:对照组(n=15)不治疗,阳性对照组(n=25)和RME实验组(n=25)。在RME后6、12、24、48和72小时对实验动物实施安乐死,随后仔细收集大脑。在低温恒温器上切割穿过三叉神经脊尾状肌、三叉神经脊间肌和三叉神经脊口的冠状切片(厚度为40µm),并进行Fos免疫组织化学处理。在光学显微镜下捕获切片的图像,并使用ImageJ软件对Fos样免疫反应神经元进行计数。结果RME诱发切牙远端化和腭中缝开放,三叉神经脊核神经元激活。实验组上颌扩弓6小时后,尾状亚核和拉里间亚核Fos阳性神经元明显增多。Fos免疫反应性在12小时显著降低,在24和48小时再次增加(P<0.001)。腭部扩张开始6小时后,在大脑中检测到最强烈的Fos样免疫反应阳性表达。
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引用次数: 1
Evaluation and comparison of the effect of incorporating zinc oxide and titanium dioxide nanoparticles on the bond strength and microleakage of two orthodontic fixed retainer adhesives 氧化锌纳米颗粒与二氧化钛纳米颗粒对两种正畸固定固位剂粘结强度及微渗漏影响的评价与比较
IF 2.1 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2023-02-01 DOI: 10.1016/j.ejwf.2022.09.002
Leila Jazi, Ahmad Sodagar, Sepehr Sobhani Kazemi, Amirhossein Mirhashemi

Background

An adhesive with both proper mechanical and antimicrobial properties seems to be beneficial. We aimed to investigate the effect of zinc oxide (ZnO) and titanium dioxide (TiO2) nanoparticles (NPs) on bond strength and microleakage of two different fixed retainer adhesives.

Methods

In this in vitro experimental study, 168 extracted human incisors were randomly divided into six groups of 28 (eight double-tooth specimens for the bond strength test and 12 specimens for the microleakage test). In three groups: Transbond XT (3M Unitek, Monrovia, CA) without NPs, with 1% ZnO NPs and with 1% TiO2 NPs were applied. The other three groups included Ortho Connect Flow (GC orthodontics, Tokyo, Japan) composite with the same order to bond a 0.175-inch multistrand wire to the lingual surfaces of the teeth. The bond strength was measured using the Universal Testing Machine, and the adhesive remnant index was reported using a stereomicroscope (Nikon, SMZ800, Tokyo, Japan). The dye-penetration method was used to determine the microleakage.

Results

For bond strength, there was no significant difference among groups. For microleakage, there was no significant difference between GC and Transbond XT groups. However, in subgroups of Transbond XT, the addition of TiO2 NPs increased the microleakage significantly in comparison with ZnO and control groups (P = 0.011). There was no significant statistical difference between the groups in terms of residual adhesives (P = 0.166).

Conclusions

Through the incorporation of 1% TiO2 and ZnO NPs into the fixed retainer adhesive, the bond strength was maintained within the clinically acceptable range. The addition of TiO2 NPs to Transbond XT significantly increased the percentage of microleakage.

背景一种具有适当机械性能和抗菌性能的粘合剂似乎是有益的。我们的目的是研究氧化锌(ZnO)和二氧化钛(TiO2)纳米颗粒(NP)对两种不同固定保持器粘合剂的结合强度和微渗漏的影响。方法在体外实验研究中,将168颗拔除的人切牙随机分为6组,每组28颗(8颗双牙标本用于粘结强度测试,12颗标本用于微渗漏测试)。在三组中:应用不含NP、含1%ZnO NP和含1%TiO2 NP的Transbond XT(3M Unitek,蒙罗维亚,CA)。其他三组包括Ortho Connect Flow(GC正畸学,日本东京)复合材料,其具有将0.175英寸多股线粘合到牙齿舌表面的相同顺序。使用万能试验机测量粘合强度,并使用立体显微镜(Nikon,SMZ800,Tokyo,Japan)报告粘合剂残留指数。采用染料渗透法测定微渗漏。结果粘接强度各组间无显著性差异。对于微渗漏,GC和Transbond XT组之间没有显著差异。然而,在Transbond XT的亚组中,与ZnO和对照组相比,TiO2 NPs的添加显著增加了微渗漏(P=0.011)。就残留粘合剂而言,两组之间没有显著的统计学差异(P=0.016),结合强度保持在临床可接受的范围内。向Transbond XT中添加TiO2 NP显著增加了微渗漏的百分比。
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引用次数: 2
In-vivo durability of Pro Seal in patients with fixed orthodontic appliances: A controlled clinical trial Pro Seal在固定正畸矫治器患者体内的耐久性:一项对照临床试验
IF 2.1 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2023-02-01 DOI: 10.1016/j.ejwf.2022.12.001
Jad Assaf, Adib Kassis, Joseph Ghoubril, Elie Khoury

Background

This clinical trial aimed at studying the durability of an orthodontic sealant (Pro Seal) used on tooth surfaces for protection against white spot lesions.

Methods

A total of 35 patients (18 females, 17 males; 17.57 ± 1.36 years) were recruited. Eligibility criteria included healthy patients of both sexes (age > 14 years), absence of labial caries, absence of defective enamel, absence of extensive restorations, and optimum oral hygiene. The participants received a single application of Pro Seal on the bonded teeth. The sealant covered the labial enamel surrounding the brackets. Participants were recalled monthly after sealant application, during which sealant layers were evaluated using an ultraviolet lamp. The assessment was realized using an index similar to the adhesive remnant index (ARI).

Results

A total of 30 participants completed the trial. ARI values dropped significantly (P < 0.001) and reached <1.5 at T1 on the index used. An ARI value of 2 was chosen as the threshold below which a tooth presented an insufficient sealant layer. The right and left sides of both jaws did not show any statistically significant difference (P > 0.05). ARI values of homolateral teeth revealed few statistically significant differences between upper and lower teeth. No statistically significant difference between the two sexes (P > 0.05) existed. No harm or disturbance was reported by any of the participants.

Conclusions

This study demonstrated that a single application of Pro Seal is effective for 4 weeks and should be renewed monthly. No interjaw, intrajaw, or intersex significant differences were found.

背景本临床试验旨在研究一种用于牙齿表面的正畸密封剂(Pro-Seal)的耐久性,以防止白斑病变。方法共招募35例患者(女18例,男17例,年龄17.57±1.36岁)。合格标准包括男女健康患者(年龄>;14岁)、无唇龋、无缺损牙釉质、无大面积修复和最佳口腔卫生。参与者只需在粘结的牙齿上涂抹一次Pro Seal。密封剂覆盖了托槽周围的唇釉。参与者每月在涂抹密封剂后被召回,期间使用紫外线灯评估密封剂层。使用类似于粘合剂残留指数(ARI)的指数来实现评估。结果共有30名参与者完成了试验。ARI值显著下降(P<;0.001)并且达到<;在所用指数的T1处为1.5。选择ARI值2作为阈值,低于该阈值,牙齿的密封剂层不足。双侧颌骨的右侧和左侧没有显示出任何统计学上的显著差异(P>;0.05)。同侧牙的ARI值显示上下牙之间几乎没有统计学上的显着差异。两种性别之间没有统计学上的显著差异(P>0.05)。没有任何参与者报告受到伤害或干扰。结论本研究表明,单次使用Pro Seal有效期为4周,应每月更新一次。没有发现颌间、颌内或胎体间的显著差异。
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引用次数: 0
Thank you reviewers 谢谢审稿人
IF 2.1 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2023-02-01 DOI: 10.1016/j.ejwf.2023.01.002
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引用次数: 0
In-house three-dimensional designing and printing customized brackets 内部三维设计和打印定制支架
IF 2.1 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2022-12-01 DOI: 10.1016/j.ejwf.2022.10.004
Nearchos C. Panayi

Digital technology is one of the major advancements during the past years that changed many aspects of our daily life. Medicine and dentistry were positively affected from the very first years of this digital evolution. Orthodontics is not an exception to this global digitization. Intraoral scanners, computer-aided design software, three-dimensional printers, and new materials were invented and introduced in dentistry and orthodontics during the last 20 years. The ability to include a small digital laboratory in the orthodontic office helped the creation of the in-house manufacturing concept. Continuously, the ability to design appliances that fit exactly to the teeth of the patient allowed the digital customization of almost every orthodontic appliance. Lately, the development of computer-aided design software called Ubrackets enabled the orthodontist to design and print customized orthodontic brackets in the orthodontic office. The designing workflow follows a specific protocol, which makes designing fast and easy. Three-dimensional printing of brackets can be performed using hybrid ceramic resin or zirconia slurry. Although some controversial studies exist, customized brackets have not been extensively studied despite that. A new term, “biological customization” is proposed, which takes into consideration the different biology of each patient, as opposed to teeth roots, bone turnover, and characteristics. Complete treatment customization should necessarily include mechanical and biological customization.

数字技术是过去几年的主要进步之一,它改变了我们日常生活的许多方面。医学和牙科在数字化发展的最初几年就受到了积极的影响。正畸学也不例外。口腔内扫描仪、计算机辅助设计软件、三维打印机和新材料在过去20年中被发明并引入牙科和正畸学。在正畸办公室中包含一个小型数字实验室的能力有助于创建内部制造概念。不断地,设计器具的能力,正好适合病人的牙齿允许几乎每一个正畸器具的数字化定制。最近,计算机辅助设计软件Ubrackets的开发使正畸医生能够在正畸办公室设计和打印定制的正畸支架。设计流程遵循特定的协议,使设计快速、简单。支架的三维打印可以使用混合陶瓷树脂或氧化锆浆料进行。虽然存在一些有争议的研究,但尽管如此,定制支架并没有得到广泛的研究。一个新的术语,“生物定制”被提出,它考虑到每个病人的不同生物学,而不是牙根,骨转换和特征。完整的处理定制必须包括机械定制和生物定制。
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引用次数: 3
In-house three-dimensional printing within the digital orthodontic workflow 数字正畸工作流程内的内部三维打印
IF 2.1 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2022-12-01 DOI: 10.1016/j.ejwf.2022.10.001
Richard R.J. Cousley

Intraoral scanning techniques, and the associated software, have revolutionized model acquisition, analysis, and virtual planning in orthodontics. Three-dimensional printing is the final aspect of this digital workflow, converting these virtual models and simulations of the tooth and occlusal movements into physical reality. This article provides an insight into how in-house three-dimensional printing is now a feasible and transformative reality for many orthodontic settings and how this empowers orthodontists to optimize their patient care.

口腔内扫描技术和相关软件已经彻底改变了正畸学中的模型获取、分析和虚拟规划。三维打印是这个数字工作流程的最后一个方面,将这些虚拟模型和牙齿和咬合运动的模拟转换为物理现实。这篇文章提供了一个深入了解如何内部三维打印现在是一个可行的和变革性的现实,许多正畸设置,这是如何授权正畸医生优化他们的病人护理。
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引用次数: 2
The ‘individual’ orthodontic patient “个体”正畸患者
IF 2.1 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2022-12-01 DOI: 10.1016/j.ejwf.2022.11.001
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引用次数: 0
Orthodontics on autopilot through digital customization and Programmed Non-Sliding Mechanics 通过数字定制和程序化的非滑动力学,实现牙齿矫正的自动驾驶
IF 2.1 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2022-12-01 DOI: 10.1016/j.ejwf.2022.10.002
Hongsheng Tong , Robert J. Lee , Andre Weissheimer , John Pham

Orthodontic tooth movement occurs in six degrees of freedom, which includes opening and closing spaces. Traditionally, opening and closing spaces are achieved with auxiliaries such as power chains or springs because all traditional bracket systems cannot achieve this tooth movement by themselves. The InBrace system has the capability to program tooth movement in all six degrees of freedom, including opening and closing spaces, through digital customization and its use of Programmed Non-Sliding Mechanics.

正畸牙齿的运动有六个自由度,包括打开和关闭间隙。传统上,打开和关闭空间是通过辅助装置,如动力链或弹簧来实现的,因为所有传统的托架系统都不能自己实现这种牙齿运动。InBrace系统能够通过数字定制和编程防滑机制,对所有六个自由度的牙齿运动进行编程,包括开合空间。
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引用次数: 0
Customized adjuncts with clear aligner therapy: “The Golden Circle Model” explained! 量身定制的辅助牙带明确的矫正治疗:“黄金圈模型”解释!
IF 2.1 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2022-12-01 DOI: 10.1016/j.ejwf.2022.10.005
Nikhilesh R. Vaid , Waddah Sabouni , Benedict Wilmes , Yashodhan M. Bichu , Digant P. Thakkar , Samar M. Adel

Clear aligners are the most debated infusion of technology into the orthodontic stratosphere and currently account for a sizable chunk of the orthodontic commercial market. Data indicate that a series of plastic aligners alone cannot resolve all the variants of malocclusion routinely treated by our specialty. Current literary consensus exists that the discrepancy between the predicted and actual clinical outcomes with clear aligner therapy (CAT) is around 50% or more, necessitating midcourse corrections, refinement, or additional aligners, or even a conversion to fixed appliances before the end of treatment. A practical panacea to improve the predictability of CAT is the addition of creative and customized adjuncts to CAT. This article, inspired by the “Golden Circle Model”, addresses questions such as the “WHY, HOW, and WHAT” of adjuncts used in combination with CAT and depicts an “inside out” approach (from WHY to WHAT) to present the rationale, stepwise clinical workflow, and the advantages of these adjuncts. The bootstrap, mini pin-supported mesialization or distalization, Yin-Yang attachments, Beneslider, Mesialslider, BMX Expander, and Computer-Aided Design (CAD) / Computer-Aided-Manufacturing (CAM)...based innovative appliance designs among others, are presented as adjuncts to CAT in this article. These adjuncts can either be used concomitantly with the aligners or planned as a separate phase of treatment before the commencement of the actual CAT, based on the type of tooth movement required and whether the planned tooth movement is indicated for a single tooth or a group of teeth. An astute clinician who wishes to expand the repertoire of malocclusions that can be successfully managed by CAT should judiciously plan the inclusion of such adjunct appliances in their aligner treatment planning.

清晰对准器是最具争议的技术注入正畸平流层,目前占正畸商业市场的相当大的一部分。数据表明,单靠一系列的塑料矫正器不能解决我们专业常规治疗的所有错颌畸形。目前的文献一致认为,明确矫正器治疗(CAT)的预测结果与实际临床结果之间的差异约为50%或更多,需要中途矫正、改进或额外的矫正器,甚至在治疗结束前转换为固定矫治器。提高CAT可预测性的一种实用的灵丹妙药是为CAT添加创造性和定制的辅助工具。本文受“黄金圈模型”的启发,解决了诸如与CAT结合使用的辅助工具的“WHY, HOW, and WHAT”等问题,并描述了一种“由内而外”的方法(从WHY到WHAT),以呈现这些辅助工具的基本原理、逐步临床工作流程和优势。引导,迷你针支持的中间化或远端化,阴阳附件,Beneslider, Mesialslider, BMX扩展器,和计算机辅助设计(CAD) /计算机辅助制造(CAM)…基于创新的设备设计等,在本文中作为CAT的附属物提出。这些辅助工具可以与矫正器一起使用,也可以在实际CAT开始前计划作为单独的治疗阶段,具体取决于所需牙齿移动的类型以及计划的牙齿移动是针对单个牙齿还是一组牙齿。一个精明的临床医生,如果希望扩大可以成功地通过CAT治疗的错颌,应该明智地计划在他们的矫正器治疗计划中包括这些辅助器具。
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引用次数: 10
期刊
Journal of the World Federation of Orthodontists
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