Orthodontic mini-screws enable precise three-dimensional control of tooth movement, enhancing treatment efficiency and reducing reliance on patient compliance. They are widely used for molar distalization in cases of crowding or anterior protrusion and for incisor intrusion in deep bite, open bite, or molar overeruption. This systematic review evaluates their effectiveness compared to conventional anchorage methods. A comprehensive literature search (2012–2024) was conducted in PubMed, ScienceDirect, and Cochrane Library, selecting in vivo and in vitro studies in English and French, whether quantitative or qualitative, retrospective or prospective. Among 2,324 identified articles, 8 met the inclusion criteria. Results indicate that molar distalization was achieved in an average of 8 months, ensuring optimized anchorage and limiting undesired side effects. Incisor intrusion proved effective, with a reduced risk of root resorption compared to conventional mechanics. However, protocol variations across studies introduce heterogeneity, affecting the comparability of outcomes. Mini-screws offer significant advantages in anchorage control, allowing greater movement efficiency and minimizing unwanted reciprocal forces. Their success depends on factors such as bone density, insertion site, and biomechanical considerations. While they represent a reliable alternative to traditional anchorage systems, careful case selection, precise planning, and proper insertion techniques are essential to maximize clinical benefits and minimize complications. Further studies with standardized methodologies are needed to establish clearer treatment guidelines.
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