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Exploring the potential applications of intraoral scanners in the treatment of cleft lip and palate deformity-A scoping review of literature. 探索口内扫描仪在唇腭裂畸形治疗中的潜在应用--文献综述。
IF 2.6 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-07-29 DOI: 10.1016/j.ejwf.2024.06.001
Karthik Sennimalai, Madhanraj Selvaraj, Hamza Parvez Siddiqui, Nitika Monga, Kathijathul Hidhaya Sameemullah

Background: In the realm of cleft lip and palate (CLP) care, the integration of intraoral scanners (IOS) may offer a promising avenue, enabling precise digital imaging, record-keeping, treatment planning and execution. This scoping review aimed to explore the current applications of IOS in CLP patients and discuss potential future directions for optimizing the utilization of IOS in cleft care.

Material and methods: The review was registered apriori in the Open Science Framework (OSF) Registries (https://doi.org/10.17605/OSF.IO/KPD34). A systematic search was conducted across various databases like Ovid MEDLINE, PubMed, Cochrane Library, Embase, Web of Science, Scopus, Google Scholar, Grey literature, and Trial registries using a broad search strategy. The articles published in any language till December 20, 2023 were considered. Studies that demonstrated the application of intraoral scanning in nonsyndromic CLP patients were included. A validated sixteen-item content assessment tool was used to evaluate the included studies. Two independent reviewers performed data extraction and content assessment.

Results: Fifteen research studies and thirteen case reports/series were included in the final analysis. Various applications included capturing intraoral and extraoral images, scanning orthodontic study models, assessing dental changes, monitoring treatment changes related to nasoalveolar molding therapy, and fabricating appliances. The content assessment showed below-average mean scores of 34.79 ± 9.37% for research studies and 39.7 ± 0.14% for case reports/series. This can be attributed to insufficient information on scanning parameters, methodology, accuracy, patient outcomes, limitations, and potential solutions. The reproducibility of landmark identification in IOS was within 0.2 mm. Patients and caregivers preferred digital impressions over traditional alginate methods, reporting positive experiences in 84.8% of cases.

Conclusion: Intraoral scanners offer good clinical accuracy and validity in assessing dentofacial and nasolabial morphology in cleft patients. Adopting IOS can streamline clinical workflows, enhance treatment accuracy, and improve patient outcomes in managing cleft lip and palate.

背景:在唇腭裂(CLP)治疗领域,口内扫描仪(IOS)的整合可能会提供一个前景广阔的途径,实现精确的数字成像、记录保存、治疗规划和执行。本范围综述旨在探讨口内扫描仪目前在唇腭裂患者中的应用,并讨论优化口内扫描仪在唇腭裂治疗中应用的潜在未来方向:该综述已事先在开放科学框架(OSF)注册中心(https://doi.org/10.17605/OSF.IO/KPD34)注册。采用广泛的检索策略,在各种数据库中进行了系统检索,如 Ovid MEDLINE、PubMed、Cochrane Library、Embase、Web of Science、Scopus、Google Scholar、灰色文献和试验登记。截至 2023 年 12 月 20 日以任何语言发表的文章均在考虑之列。其中包括证明口腔内扫描在非综合症中耳炎患者中应用的研究。采用经过验证的 16 项内容评估工具对纳入的研究进行评估。两名独立审稿人进行了数据提取和内容评估:最终分析包括 15 项研究和 13 项病例报告/系列报告。各种应用包括捕捉口内和口外图像、扫描正畸研究模型、评估牙齿变化、监测与鼻齿槽成型疗法相关的治疗变化以及制作矫治器。内容评估显示,研究报告的平均得分低于平均水平(34.79 ± 9.37%),病例报告/系列报告的平均得分低于平均水平(39.7 ± 0.14%)。这可能是由于有关扫描参数、方法、准确性、患者结果、局限性和潜在解决方案的信息不足。IOS 的地标识别再现性在 0.2 毫米以内。与传统的藻酸盐印模方法相比,患者和护理人员更喜欢数字印模,84.8%的病例报告了积极的体验:口内扫描仪在评估唇裂患者的牙面和鼻唇形态方面具有良好的临床准确性和有效性。采用口内扫描仪可以简化临床工作流程,提高治疗的准确性,改善唇腭裂患者的治疗效果。
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引用次数: 0
Orofacial dysfunction in cleft lip and palate patients using the nordic orofacial test-screening. 使用北欧口腔测试筛查唇腭裂患者的口腔功能障碍。
IF 2.6 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-07-17 DOI: 10.1016/j.ejwf.2024.05.002
Neda Eslami, Erfan Bardideh, Pourya Tatari, Lohrasb Dehghani

Introduction: The Nordic Orofacial Test-Screening (NOT-S) protocol serves as a widely recognized tool for assessing orofacial dysfunction comprehensively. This study aimed to compare orofacial dysfunction between unilateral (UCLP) and bilateral (BCLP) cleft lip and palate patients using the NOT-S.

Materials and methods: This descriptive cross-sectional study enrolled 104 patients, comprising 72 with unilateral cleft lip and palate (UCLP) and 32 with bilateral cleft lip and palate (BCLP) referred to the cleft lip and palate clinic of Mashhad Dental School. Orofacial dysfunction was assessed using the Nordic Orofacial Test-Screening (NOT-S), which includes a structured interview and clinical examinations encompassing 6 domains each. Statistical analysis utilized Mann-Whitney, Fisher's exact, and Chi-square tests, with significance set at P < 0.05.

Results: No significant differences were found in structured interview (P = 0.45), clinical examination (P = 0.45), or total NOT-S score (P = 0.11) between the two types of cleft lip and palate.

Conclusion: Based on NOT-S assessment, patients with unilateral (UCLP) and bilateral (BCLP) cleft lip and palate exhibited comparable orofacial dysfunctions. In the structured interview, the most prevalent issues were identified in the domain of chewing and swallowing for both cleft types. In clinical examination, unilateral cleft lip and palate patients commonly experienced facial problems at rest, while bilateral cleft lip and palate patients frequently encountered challenges with speaking. However, these differences were not statistically significant.

简介北欧口面部测试筛查(NOT-S)方案是公认的全面评估口面部功能障碍的工具。本研究旨在使用 NOT-S 对单侧(UCLP)和双侧(BCLP)唇腭裂患者的口面部功能障碍进行比较:这项描述性横断面研究共招募了 104 名患者,其中包括 72 名单侧唇腭裂患者(UCLP)和 32 名双侧唇腭裂患者(BCLP),他们都是转诊到马什哈德牙科学校唇腭裂诊所的。口面部功能障碍采用北欧口面部测试筛查(NOT-S)进行评估,包括结构化访谈和临床检查,每项检查涵盖 6 个领域。统计分析采用曼-惠特尼检验、费雪精确检验和卡方检验,显著性以 P < 0.05 为限:结果:两类唇腭裂患者在结构化访谈(P = 0.45)、临床检查(P = 0.45)或 NOT-S 总分(P = 0.11)方面均无明显差异:结论:根据 NOT-S 评估,单侧(UCLP)和双侧(BCLP)唇腭裂患者的口面部功能障碍具有可比性。在结构化访谈中,两种唇腭裂患者最普遍的问题都出现在咀嚼和吞咽方面。在临床检查中,单侧唇腭裂患者通常在休息时出现面部问题,而双侧唇腭裂患者则经常在说话时遇到困难。然而,这些差异在统计学上并不显著。
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引用次数: 0
Unplanned tooth movement in deepbite correction with Invisalign: A retrospective study 使用隐适美矫正器矫正深咬合时的意外牙齿移动:一项回顾性研究。
IF 2.1 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-06-01 DOI: 10.1016/j.ejwf.2023.12.008
Mais M. Sadek , Reem Alhashmi

Background

This study aimed to investigate unplanned tooth movements in deepbite correction with Invisalign.

Methods

The sample consisted of 34 adult patients with deepbite malocclusion treated with Invisalign. Pretreatment and predicted digital models were exported from ClinCheck software, while the post-treatment model was obtained from an intraoral scan taken at the end of the first set of aligners. Digital models’ superimposition was done using the eModel “Compare” software. Frequency and percentage of occurrence of unplanned linear and angular movements, their magnitude, and direction were then determined. In addition, comparison of unplanned movements was performed between anterior and posterior teeth as well as between linear and angular measurements.

Results

The percentage of unplanned movements ranged from 1.68% to 25.63% in the maxilla and 3.36% to 23.95% in the mandible, being most evident in the first and second molars. Unplanned movements were statistically significantly more frequent in posterior teeth compared with the anterior teeth (P > 0.05). In addition, the frequency of angular movements was statistically significantly higher for each tooth than linear movement (P < 0.05) with a higher mean value. Unplanned mesiodistal movements were the least frequent.

Conclusions

Unplanned linear as well as angular movements were evident in almost all teeth. Unplanned faciolingual inclination and mesiodistal angulation movements were the most frequently observed. Unplanned vertical movements can affect the predictability of deepbite correction and thus merit particular attention in those cases.

背景: 本研究旨在调查隐适美矫正深咬合过程中的非计划性牙齿移动:本研究旨在调查使用隐适美矫正器进行深咬合矫正过程中的非计划性牙齿移动:样本包括 34 名接受隐适美矫正治疗的深咬合畸形成年患者。治疗前和预测的数字模型从 ClinCheck 软件中导出,而治疗后模型则从第一套矫治器结束时的口内扫描中获得。数字模型的叠加使用 eModel "Compare "软件完成。然后确定非计划线性和角度移动的发生频率和百分比、幅度和方向。此外,还对前牙和后牙之间以及线性和角度测量之间的计划外移动进行了比较:上颌和下颌的计划外移动比例分别为 1.68% 至 25.63%,3.36% 至 23.95%,其中以第一和第二磨牙最为明显。与前牙相比,后牙发生计划外移动的频率明显更高(P > 0.05)。此外,从统计学角度看,每颗牙齿的角度移动频率明显高于线性移动(P < 0.05),且平均值更高。结论:结论:几乎所有牙齿都存在计划外的线性和角度移动。结论:几乎所有牙齿都存在计划外的线性和角度移动,计划外的面倾斜和牙间隙角度移动最为常见。计划外的垂直移动会影响深咬合矫正的可预测性,因此在这些病例中值得特别注意。
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引用次数: 0
Accuracy of Dolphin Imaging software in predicting soft tissue changes of Class II Division 1 incisor relationship treated by all first premolar extraction compared with post-treatment lateral cephalogram Dolphin Imaging 软件在预测第一前磨牙全部拔除术治疗的 II 类 1 级切牙关系的软组织变化方面的准确性与治疗后侧位头相图的比较。
IF 2.1 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-06-01 DOI: 10.1016/j.ejwf.2024.01.005
Nikunj Maniyar , A.T. Prakash , H.C. Kiran Kumar , Puja C. Yavagal

Background

To quantify the accuracy of Dolphin Imaging software in predicting soft tissue changes of Class II Division 1 incisor relationship treated by all first premolar extraction compared with actual changes.

Methods

Pretreatment and post-treatment lateral cephalograms of 30 young adult subjects (25 females and 5 males; age range of 16 to 21 years) were imported and traced in Dolphin Imaging software (version 11.95). Tracings of actual treatment results and the Dolphin predicted treatment outcome were superimposed to calculate the prediction errors. The mean difference for the Holdaway soft tissue analysis and at each landmark was measured in both the X and Y axes. Paired t test was used to compare the statistical differences in Holdaway soft tissue analysis parameters.

Results

There were significant differences between the predicted and actual values in three parameters of the Holdaway soft tissue analysis (P < 0.05). The overall accuracy of estimation was better in vertical direction than horizontal. Prediction of upper and lower lip landmarks was overestimated horizontally and underestimated vertically, whereas that belonging to chin was underestimated horizontally and overestimated vertically. Soft tissue nasion and soft tissue A-point were most accurately predicted, whereas the least accuracy was found in soft tissue chin region.

Conclusions

Dolphin Imaging Software (version 11.95) can be accurate enough for use in patient communication and education but should be used with caution. It is most accurate in predicting soft tissue changes in the nasion and A-point regions, but least accurate in chin region.

背景:旨在量化 Dolphin Imaging 软件在预测所有第一前磨牙拔除术后 II 类 1 切牙关系软组织变化时的准确性:目的:与实际变化相比,量化 Dolphin Imaging 软件预测第一前磨牙全部拔除后第二类第一切牙关系软组织变化的准确性:导入 30 名年轻成人(25 名女性和 5 名男性,年龄在 16 至 21 岁之间)的治疗前和治疗后的侧方头影,并在 Dolphin Imaging 软件(11.95 版)中进行描记。将实际治疗结果和 Dolphin 预测的治疗结果叠加在一起,以计算预测误差。在 X 和 Y 轴上测量 Holdaway 软组织分析和每个地标的平均差异。采用配对 t 检验比较 Holdaway 软组织分析参数的统计差异:结果:Holdaway 软组织分析的三个参数的预测值和实际值之间存在明显差异(P < 0.05)。垂直方向的整体估计准确性优于水平方向。上唇和下唇地标的预测值在水平方向上被高估,在垂直方向上被低估,而下巴地标的预测值在水平方向上被低估,在垂直方向上被高估。软组织鼻翼和软组织 A 点的预测准确度最高,而软组织颏部的预测准确度最低:结论:海豚成像软件(11.95 版)的准确度足以用于患者沟通和教育,但应谨慎使用。该软件在预测鼻翼和 A 点区域软组织变化方面最为准确,但在预测下巴区域软组织变化方面准确性最低。
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引用次数: 0
En masse retraction of anterior teeth through rapid periodontal distraction by a retraction screw: A randomized control trial 通过牵引螺钉快速牵引牙周,对前牙进行大规模牵引:随机对照试验。
IF 2.1 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-06-01 DOI: 10.1016/j.ejwf.2024.01.004
Hibu Dora , Mubasshir Ahmed Shaikh , Seema Gupta , Sameena Begum Maqhbool , Salim Shamsuddin , Saraswati Raghunath Kokate

Background

Rapid distraction of the periodontal ligament is an effective method to shorten the orthodontic treatment time. The objectives of the present study were to assess the effects of an HYCON device (Adenta GmbH, Germany) on the rate of en masse retraction of the anterior teeth, duration of retraction, anchorage loss, root resorption, and soft tissue changes.

Methods

This study was conducted on 60 female patients aged >18 years, divided randomly into two equal groups: Group 1 comprised 30 patients with HYCON, and group 2 comprised 30 patients with nickel-titanium closed coil springs. Skeletal, dental, and soft tissue changes were evaluated on pre- and post-retraction lateral cephalograms, and the rates of anterior tooth movement and anchorage loss were assessed monthly on the dental casts of the patients. Root resorption was assessed using intraoral periapical radiograph. Student's t test was used for the analysis of parametric data, and the Mann-Whitney U test was used for nonparametric data.

Results

HYCON significantly shortened the retraction duration by 3 months. The rate of anterior teeth retraction was two times faster in group 1, compared with group 2. There was a significant difference in the anchorage loss between the groups in only first 2 months of treatment. Group 2 showed significantly more root resorption and soft tissue changes than group 1 (P < 0.05).

Conclusions

HYCON is an effective device for significantly shortening the duration of retraction with anchorage loss of 2 to 2.5 mm. However, careful monitoring for possible root resorption should be performed.

背景:快速牵引牙周韧带是缩短正畸治疗时间的有效方法。本研究的目的是评估 HYCON 装置(Adenta GmbH,德国)对前牙整体牵引率、牵引持续时间、固定丧失、牙根吸收和软组织变化的影响:研究对象为 60 名年龄在 18 岁以上的女性患者,随机分为两组:第一组包括 30 名使用 HYCON 的患者,第二组包括 30 名使用镍钛封闭螺旋弹簧的患者。通过牵引前和牵引后的头颅侧位片评估骨骼、牙齿和软组织的变化,每月通过患者的牙模评估前牙移动率和固位丧失率。使用口内根尖周X光片评估牙根吸收情况。参数数据采用学生 t 检验,非参数数据采用 Mann-Whitney U 检验:结果:HYCON明显缩短了3个月的反牙合时间。仅在治疗的前 2 个月,各组间的锚固力损失有显著差异。第 2 组的牙根吸收和软组织变化明显多于第 1 组(P < 0.05):结论:HYCON 是一种有效的装置,能明显缩短锚定丧失 2 到 2.5 mm 的缩回时间。结论:HYCON 是一种有效的装置,可大大缩短锚定丧失 2 到 2.5 mm 的牵引持续时间,但应仔细监测可能发生的牙根吸收。
{"title":"En masse retraction of anterior teeth through rapid periodontal distraction by a retraction screw: A randomized control trial","authors":"Hibu Dora ,&nbsp;Mubasshir Ahmed Shaikh ,&nbsp;Seema Gupta ,&nbsp;Sameena Begum Maqhbool ,&nbsp;Salim Shamsuddin ,&nbsp;Saraswati Raghunath Kokate","doi":"10.1016/j.ejwf.2024.01.004","DOIUrl":"10.1016/j.ejwf.2024.01.004","url":null,"abstract":"<div><h3>Background</h3><p>Rapid distraction of the periodontal ligament is an effective method to shorten the orthodontic treatment time. The objectives of the present study were to assess the effects of an HYCON device (Adenta GmbH, Germany) on the rate of en masse retraction of the anterior teeth, duration of retraction, anchorage loss, root resorption, and soft tissue changes.</p></div><div><h3>Methods</h3><p>This study was conducted on 60 female patients aged &gt;18 years, divided randomly into two equal groups: Group 1 comprised 30 patients with HYCON, and group 2 comprised 30 patients with nickel-titanium closed coil springs. Skeletal, dental, and soft tissue changes were evaluated on pre- and post-retraction lateral cephalograms, and the rates of anterior tooth movement and anchorage loss were assessed monthly on the dental casts of the patients. Root resorption was assessed using intraoral periapical radiograph. Student's <em>t</em> test was used for the analysis of parametric data, and the Mann-Whitney <em>U</em> test was used for nonparametric data.</p></div><div><h3>Results</h3><p>HYCON significantly shortened the retraction duration by 3 months. The rate of anterior teeth retraction was two times faster in group 1, compared with group 2. There was a significant difference in the anchorage loss between the groups in only first 2 months of treatment. Group 2 showed significantly more root resorption and soft tissue changes than group 1 (<em>P</em> &lt; 0.05).</p></div><div><h3>Conclusions</h3><p>HYCON is an effective device for significantly shortening the duration of retraction with anchorage loss of 2 to 2.5 mm. However, careful monitoring for possible root resorption should be performed.</p></div>","PeriodicalId":43456,"journal":{"name":"Journal of the World Federation of Orthodontists","volume":"13 3","pages":"Pages 113-122"},"PeriodicalIF":2.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140176989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomechanics of conventional and miniscrew-assisted rapid palatal expansion 传统和微型螺钉辅助快速腭部扩张术的生物力学。
IF 2.1 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-06-01 DOI: 10.1016/j.ejwf.2024.03.002
Shivam Mehta , Sarah Abu Arqub , Meenakshi Vishwanath , Madhur Upadhyay , Sumit Yadav

Posterior Crossbite is a common condition resulting because of transverse maxillary deficiency. The growth of the craniofacial complex finishes first in the transverse dimension, followed by sagittal and vertical dimensions. Conventional rapid palatal expansion (RPE) appliances are commonly used to correct transverse maxillary deficiency. Although RPE is efficient in correcting posterior crossbite, it results in dental side effects such as buccal tipping of maxillary molars, root resorption, bone dehiscence, and relapse. Mini-implant-assisted RPE has been introduced to increase the skeletal effects of expansion especially in patients with increased maturation and greater interdigitation of midpalatal suture. This article will review the biomechanics of RPE and mini-implant-assisted RPE. Additionally, the different designs of MARPE and the long-term clinical effects of expansion appliances will also be discussed in detail.

后交叉咬合是上颌骨横向缺损导致的一种常见疾病。颅面复合体的生长首先在横向完成,其次是矢状和垂直方向。传统的快速腭扩展矫治器通常用于矫正上颌骨横向缺损。虽然 RPE 能有效矫正后交叉咬合,但它会导致牙科副作用,如上颌磨牙颊侧倾倒、牙根吸收、牙槽骨开裂和复发。目前已引入微型种植体辅助 RPE,以增加扩弓的骨骼效果,尤其是对成熟度增加和腭中缝相互咬合增加的患者。本文将回顾 RPE 和微型种植体辅助 RPE 的生物力学。此外,还将详细讨论 MARPE 的不同设计以及扩弓矫治器的长期临床效果。
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引用次数: 0
Retrospective comparison of two different miniscrew-supported molar distalization methods applied in the buccal and palatal regions 两种不同的微型螺钉支撑臼齿远端矫治方法在颊和腭区应用的回顾性比较。
IF 2.1 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-06-01 DOI: 10.1016/j.ejwf.2024.01.006
Yavuz Selim Aslan, Mehmet Ali Yavan, Nihal Hamamci

Background

To compare dentofacial effects of distalization with miniscrew-supported pendulum and infrazygomatic crest miniscrews.

Methods

The study included 36 patients whose lateral cephalometric radiographs were obtained before (T0) and after (T1) distalization. Patients were divided into two groups according to the treatment methods: 1) distalization with miniscrew-supported pendulum (MSP) (n = 19; 14 girls and 5 boys; mean age 16.9 ± 1.46 years) and 2) distalization with infrazygomatic crest (IZC) miniscrews (n = 17; 8 girls and 9 boys; mean age 17.0 ± 1.68 years). Dental, skeletal and soft tissue measurements were performed on lateral cephalograms taken from individuals.

Results

A significant molar distalization was achieved both in the MSP group (3.52 ± 0.76 mm at 8.71 ± 2.02 months) and the IZC group (3.5 ± 0.74 mm at 9.7 ± 2.5 months) (P < 0.001 for both). Premolar distalization was significantly lower in the MSP group (1.73 ± 1.09 mm) than in the IZC group (2.81 ± 0.79 mm) (P < 0.01). Significant molar tipping was observed in both groups (P < 0.001), while no significant difference was found between the groups (P > 0.05). Retrusion of maxillary incisors were significantly higher in the IZC group (2.75 mm) than in the MSP group (0.98 mm) (P < 0.01). A significant difference was found between the two groups with regard to the changes in overjet and overbite (P < 0.05).

Conclusions

Both distalization methods were found to be effective in achieving a Class I molar relationship in patients with Class II malocclusion.

背景:比较微型螺钉支撑的摆锤式和颧嵴下微型螺钉的牙面远端化效果:比较使用微型螺钉支撑的摆锤式和颧嵴下微型螺钉进行远端矫治的颌面效果:研究包括 36 名患者,他们的头颅侧位X光片分别在矫治前(T0)和矫治后(T1)拍摄。根据治疗方法将患者分为两组:1)用微型螺钉支撑摆锤(MSP)进行远端矫治(n = 19;14 名女孩和 5 名男孩;平均年龄为 16.9 ± 1.46 岁);2)用颧下嵴(IZC)微型螺钉进行远端矫治(n = 17;8 名女孩和 9 名男孩;平均年龄为 17.0 ± 1.68 岁)。对每个人的头颅侧位片进行了牙齿、骨骼和软组织测量:MSP组(8.71±2.02个月时为3.52±0.76毫米)和IZC组(9.7±2.5个月时为3.5±0.74毫米)的臼齿远化均有明显改善(P < 0.001)。MSP 组(1.73 ± 1.09 mm)的前磨牙远端化明显低于 IZC 组(2.81 ± 0.79 mm)(P < 0.01)。两组中均观察到明显的臼齿倾倒(P < 0.001),而组间无明显差异(P > 0.05)。IZC 组的上颌切牙后缩(2.75 毫米)明显高于 MSP 组(0.98 毫米)(P < 0.01)。两组在过咬合和过咬合的变化方面存在明显差异(P < 0.05):结论:两种远端矫治方法都能有效地使Ⅱ类错颌畸形患者获得Ⅰ类臼齿关系。
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引用次数: 0
Microplastics: An orthodontic concern! 微塑料:正畸学关注的问题!
IF 2.1 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-06-01 DOI: 10.1016/j.ejwf.2024.05.001
Vinod Krishnan (Editor-in-Chief)
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引用次数: 0
Increased susceptibility for nonsyndromic cleft lip with or without cleft palate by SLC19A1 80G>A genetic variation SLC19A1 80G>A 基因变异增加了非综合征唇裂伴或不伴腭裂的易感性。
IF 2.1 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-06-01 DOI: 10.1016/j.ejwf.2024.01.002
Archana Patel , Nisha Sahu , Henu Kumar Verma , L.V.K.S. Bhaskar

Background

The disruption of craniofacial developmental pathways during early embryogenesis can lead to conditions such as nonsyndromic cleft lip with or without cleft palate (NSCL/P). Several lines of evidence indicate that inadequate maternal nutrition causes low folate levels during the periconceptional period, resulting in NSCL/P. Although substantial research has been conducted on the possible link between SLC19A1 genetic variants and NSCL/P, the association between SLC19A1 80G>A (rs1051266) and NSCL/P remains unclear. In the present study, the associations of SLC19A1 80G>A with NSCL/P risk were assessed by calculating the pooled odds ratios (ORs) and 95% confidence intervals (CIs) by meta-analyses.

Methods

Following the PRISMA guidelines, a meta-analysis was conducted on 10 studies assessing the NSCL/P risk associated with SLC19A1 80G>A variant. To ascertain the degree of relationship between the SLC19A1 80G>A genetic variant and the risk of NSCL/P, data were analyzed in allelic, recessive and dominant genetic models. CI of OR for each study and the pooled data were obtained. All statistical analyses were conducted utilizing the MetaGenyo software tool, which integrates the adjustment of P values for multiple testing through the Bonferroni method.

Results

The pooled analysis showed that SLC19A1 80G>A variant significantly increased the NSCL/P risk in the allelic model (OR 1.39; 95% CI 1.00–1.92), recessive model (OR 1.37; 95% CI 1.03–1.82) and dominant models (OR 1.7; 95% CI 1.05–2.90). Publication bias was not observed.

Conclusions

This study supports that the SLC19A1 80G>A genetic variant is associated with NSCL/P risk.

背景:在早期胚胎发育过程中,颅面发育途径的中断可导致非综合征性唇裂伴或不伴腭裂(NSCL/P)等疾病。多项证据表明,母体营养不足会导致围孕期叶酸水平过低,从而导致非综合征性唇裂伴或不伴腭裂(NSCL/P)。尽管对 SLC19A1 基因变异与 NSCL/P 之间可能存在的联系进行了大量研究,但 SLC19A1 80G>A (rs1051266) 与 NSCL/P 之间的关联仍不清楚。在本研究中,通过荟萃分析计算汇总的几率比(ORs)和95%置信区间(CIs),评估了SLC19A1 80G>A与NSCL/P风险的相关性:根据PRISMA指南,对10项评估与SLC19A1 80G>A变异相关的NSCL/P风险的研究进行了荟萃分析。为了确定 SLC19A1 80G>A 基因变异与 NSCL/P 风险之间的关系程度,对数据进行了等位、隐性和显性遗传模型分析。获得了每项研究和汇总数据的 OR CI。所有统计分析均利用 MetaGenyo 软件工具进行,该工具通过 Bonferroni 方法对多重检验的 P 值进行了调整:汇总分析显示,在等位基因模型(OR 1.39;95% CI 1.00-1.92)、隐性模型(OR 1.37;95% CI 1.03-1.82)和显性模型(OR 1.7;95% CI 1.05-2.90)中,SLC19A1 80G>A变异显著增加了NSCL/P风险。未观察到发表偏倚:本研究证实,SLC19A1 80G>A 基因变异与 NSCL/P 风险有关。
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引用次数: 0
Evaluation of pain intensity with prostaglandin E2 biomarker and visual analog scale during initiation of orthodontic treatment: A prospective study 前列腺素E2生物标志物和视觉模拟量表评估正畸治疗初期疼痛强度:一项前瞻性研究。
IF 2.1 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-04-01 DOI: 10.1016/j.ejwf.2023.10.002
Yuvashree Raghupathy , Venkateswaran Ananthanarayanan , Vignesh Kailasam

Objectives

The aim of this study was to assess subjectively and objectively, at which timepoint the patient undergoing fixed orthodontic treatment will have maximum pain during the initiation of orthodontic treatment.

Materials and Method

A total of 22 patients (21 ± 2.7 years, [15 female and 7 male]) requiring extraction of maxillary first premolar participated in the study. Following bonding, an initial archwire of 0.016" NiTi was placed with a distal force of 100 g applied to the canines. The concentration of prostaglandin E2 (PGE2) in the gingival crevicular fluid was assessed at four time points: 1 hour before (T0); 24 hours (T1); 48 hours (T2); 72 hours (T3) after initial archwire placement. The pain intensity was recorded with visual analog scale.

Results

The concentration of PGE2 increased from T0 to T1. The highest concentration was observed at T2 following which there was a mild decline at T3. Statistically significant difference in the PGE2 concentration was observed between T0 to T1 and T1 to T2. The visual analogue scale (VAS) scores increased from T0 to T1. The highest score was observed at T2 followed by a decline at T3. A statistically significant difference in the VAS score was noted between T0 to T1 and T2 to T3. On correlating PGE2 and VAS score, a weak negative correlation was noted between T0 to T1 and no correlation was noted between T1 to T2 and T2 to T3.

Conclusion

The patients experience maximum pain between 24 hours (T1) and 48 hours (T2) following initial archwire placement. The highest concentration of PGE2 and VAS score was observed at 48 hours (T2).

目的:本研究的目的是主观和客观地评估在正畸治疗开始时,接受固定正畸治疗的患者在哪个时间点会有最大的疼痛。材料与方法:共有22例需要拔除上颌第一前磨牙的患者(21±2.7岁,[女性15例,男性7例])参与研究。粘接后,将一根0.016" NiTi的初始弓丝放置在犬身上,并在远端施加100 g的力。在4个时间点检测龈沟液中前列腺素E2 (PGE2)的浓度:1小时前(T0);24小时(T1);48小时(T2);初始弓丝放置后72小时(T3)。用视觉模拟量表记录疼痛强度。结果:PGE2浓度随T0 ~ T1升高。T2时浓度最高,T3时略有下降。PGE2浓度在T0 ~ T1、T1 ~ T2间差异有统计学意义。视觉模拟评分(VAS)评分从T0增加到T1。T2时评分最高,T3时评分下降。T0 ~ T1、T2 ~ T3 VAS评分差异有统计学意义。在PGE2与VAS评分的相关性方面,T0 ~ T1呈弱负相关,T1 ~ T2、T2 ~ T3无相关性。结论:患者在首次放置弓丝后24小时(T1)至48小时(T2)疼痛最大。PGE2浓度和VAS评分在48h (T2)时达到最高。
{"title":"Evaluation of pain intensity with prostaglandin E2 biomarker and visual analog scale during initiation of orthodontic treatment: A prospective study","authors":"Yuvashree Raghupathy ,&nbsp;Venkateswaran Ananthanarayanan ,&nbsp;Vignesh Kailasam","doi":"10.1016/j.ejwf.2023.10.002","DOIUrl":"10.1016/j.ejwf.2023.10.002","url":null,"abstract":"<div><h3>Objectives</h3><p>The aim of this study was to assess subjectively and objectively, at which timepoint the patient undergoing fixed orthodontic treatment will have maximum pain during the initiation of orthodontic treatment.</p></div><div><h3>Materials and Method</h3><p>A total of 22 patients (21 ± 2.7 years, [15 female and 7 male]) requiring extraction of maxillary first premolar participated in the study. Following bonding, an initial archwire of 0.016\" NiTi was placed with a distal force of 100 g applied to the canines. The concentration of prostaglandin E2 (PGE2) in the gingival crevicular fluid was assessed at four time points: 1 hour before (T0); 24 hours (T1); 48 hours (T2); 72 hours (T3) after initial archwire placement. The pain intensity was recorded with visual analog scale.</p></div><div><h3>Results</h3><p>The concentration of PGE2 increased from T0 to T1. The highest concentration was observed at T2 following which there was a mild decline at T3. Statistically significant difference in the PGE2 concentration was observed between T0 to T1 and T1 to T2. The visual analogue scale (VAS) scores increased from T0 to T1. The highest score was observed at T2 followed by a decline at T3. A statistically significant difference in the VAS score was noted between T0 to T1 and T2 to T3. On correlating PGE2 and VAS score, a weak negative correlation was noted between T0 to T1 and no correlation was noted between T1 to T2 and T2 to T3.</p></div><div><h3>Conclusion</h3><p>The patients experience maximum pain between 24 hours (T1) and 48 hours (T2) following initial archwire placement. The highest concentration of PGE2 and VAS score was observed at 48 hours (T2).</p></div>","PeriodicalId":43456,"journal":{"name":"Journal of the World Federation of Orthodontists","volume":"13 2","pages":"Pages 72-77"},"PeriodicalIF":2.1,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138177543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Journal of the World Federation of Orthodontists
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