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Biomechanical evaluation of attachment geometries for labio-lingual inclinations in maxillary incisors of Class II Division 2 malocclusion: A 3D finite element analysis. II类2分错颌切牙唇-舌倾斜附着几何的生物力学评价:三维有限元分析。
IF 3.2 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-10 DOI: 10.1016/j.ejwf.2025.10.006
Dhaval Fadia, Puneet Batra, Nikhillesh Vaiid

Background: Class II Division 2 malocclusion presents biomechanical challenges due to retroclined maxillary incisors, often complicated by soft tissue constraints. Clear aligner therapy (CAT), though patient-friendly, shows limitations in predictably modifying labiolingual inclination. Recent attachment design advancements offer potential solutions but require biomechanical validation. Finite element modelling (FEM) serves as an effective analytical tool to evaluate these mechanics. The present study aims to compare the efficacy of three attachment geometries in expressing labiolingual inclination of maxillary incisors in a FEM model simulating Class II Division 2 malocclusion EIC.

Materials and methods: A FEM of the maxilla was generated from CBCT data of a Class II Division 2 patient. Labiolingual inclinations of 5°, 10°, 15°, 20°, and 25° were simulated on maxillary central and lateral incisors. Three attachment designs were evaluated: labial horizontal attachments (LHA), palatal horizontal attachments with labial power ridges (PHALPR) and labial-palatal reciprocal power ridges (LPRPR). Displacement and von Mises stress were calculated for teeth and supporting structures.

Results: LPRPR showed the highest displacement (0.1418 mm) and stress (384.89 MPa), followed by PHALPR (0.1211 mm; 327.35 MPa) and LHA (0.1048 mm; 204.65 MPa) respectively. Lateral incisors demonstrated greater displacement and stress than central incisors. Supporting structures showed peak stress under LPRPR conditions.

Conclusions: Attachment geometry significantly affects labiolingual inclination expression in CAT. Among the tested designs, the LPRPR configuration demonstrated superior biomechanical efficiency for managing labiolingual inclination in Class II Division 2 malocclusion.

背景:II类2分错牙合由于上颌门牙后倾导致生物力学方面的挑战,通常伴有软组织限制。清除矫正器疗法(CAT)虽然对患者友好,但在可预测地改变唇舌倾向方面显示出局限性。最近的附件设计进步提供了潜在的解决方案,但需要生物力学验证。有限元建模(FEM)是评估这些力学特性的有效分析工具。本研究旨在比较三种附着体几何形状对上颌切牙唇舌倾斜度的表达效果,以模拟II类2类错牙合EIC的有限元模型。材料与方法:利用2类患者的CBCT数据建立上颌骨有限元模型。上颌中切牙和侧切牙的唇舌倾斜度分别为5°、10°、15°、20°和25°。评估了三种附着体设计:唇水平附着体(LHA)、腭水平附着体(PHALPR)和唇-腭互力脊(LPRPR)。计算齿和支撑结构的位移和von Mises应力。结果:LPRPR的位移(0.1418 mm)和应力(384.89 MPa)最大,其次是PHALPR (0.1211 mm; 327.35 MPa)和LHA (0.1048 mm; 204.65 MPa)。侧切牙表现出比中切牙更大的位移和应力。在LPRPR条件下,支撑结构的应力达到峰值。结论:附着物几何形状显著影响CAT的唇舌倾斜度表达。在测试设计中,LPRPR配置在控制II类2分错错的唇舌倾斜方面表现出优异的生物力学效率。
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引用次数: 0
Effectiveness of varying alternating rapid maxillary expansions and constrictions (Alt-RAMEC) durations on maxillary protraction in noncleft Class III malocclusion: A systematic review and meta-analysis. 上颌快速扩张和收缩(Alt-RAMEC)交替持续时间对非裂型III类错牙合上颌前伸的影响:一项系统回顾和荟萃分析。
IF 3.2 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-05 DOI: 10.1016/j.ejwf.2025.10.005
Hamza Parvez Siddiqui, Anne Marie Kuijpers-Jagtman, Saraa Angel, Karthik Sennimalai, Madhanraj Selvaraj

Background: This systematic review aims to assess whether extending Alt-RAMEC (Alternating Rapid Maxillary Expansions and Constrictions) protocols from four to nine weeks yields superior skeletal, dental, and soft-tissue outcomes in growing noncleft Class III patients when compared to conventional rapid maxillary expansion (RME).

Methods: A systematic literature search was conducted across the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, Scopus, Embase, Web of Science, Google Scholar, Ovid MEDLINE, EBSCOhost, and LILACS databases over the past 20 years up to 7 January 2025. Clinical trials comparing cephalometrically conventional RME with Alt-RAMEC-assisted maxillary protraction in growing noncleft Class III subjects were included. Risk of bias was assessed using the Methodological Index for Nonrandomized Studies (MINORS) and the Cochrane Risk of Bias (RoB 2) tool. A random-effects meta-analysis using RevMan was conducted for quantitative synthesis.

Results: Out of 1847 articles screened, 24 studies were included for qualitative synthesis and 11 studies for meta-analysis. The five-week Alt-RAMEC protocol showed a statistically significant improvement in the ANB angle compared to RME (mean difference 1.37°; 95% confidence intervals 0.85-1.89; P < 0.01; c2 = 2.14; I2 = 0%). However, both 7-week and 9-week protocols demonstrated no significant advantage over conventional RME/facemask.

Conclusions: Only the five-week Alt-RAMEC protocol offers a statistically significant but clinically negligible improvement in maxillofacial, dental, and soft-tissue outcomes over conventional RME-assisted protraction in managing growing noncleft Class III malocclusion using a Hyrax-type expander. However, this is supported by only moderate to weak evidence.

背景:本系统综述旨在评估与传统的快速上颌扩张(RME)相比,将Alt-RAMEC(交替快速上颌扩张和收缩)方案延长4至9周是否能在生长中的非唇裂III类患者中获得更好的骨骼、牙齿和软组织预后。方法:系统检索Cochrane Central Register of Controlled Trials (Central)、PubMed、Scopus、Embase、Web of Science、谷歌Scholar、Ovid MEDLINE、EBSCOhost和LILACS数据库过去20年至2025年1月7日的文献。包括在生长中的非唇裂III类受试者中比较头测法常规RME与alt - ramec辅助上颌牵引的临床试验。采用非随机研究方法学指数(methodology Index for non - random Studies,简称minor)和Cochrane Risk of bias (RoB 2)工具评估偏倚风险。采用RevMan随机效应meta分析进行定量综合。结果:在筛选的1847篇文章中,24篇研究被纳入定性综合,11篇研究被纳入meta分析。与RME相比,5周Alt-RAMEC方案在ANB角度上有统计学意义的改善(平均差1.37°;95%可信区间0.85-1.89;P < 0.01; c2 = 2.14; I2 = 0%)。然而,7周和9周的治疗方案与传统的RME/面罩相比没有明显的优势。结论:只有5周的Alt-RAMEC方案提供了统计学上显著的改善,但在临床上可以忽略,在使用hyrax型扩张器治疗生长中的非裂型III类错颌时,与传统的rme辅助牵引相比,在颌面部、牙齿和软组织方面的改善可以忽略。然而,只有中等到微弱的证据支持这一观点。
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引用次数: 0
Performance of four chatbots versus orthodontists in answering multiple-choice questions in orthodontics and dentofacial orthopedics. 四个聊天机器人与正畸医生在正畸和牙面矫形中回答多项选择题的表现。
IF 3.2 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-02 DOI: 10.1016/j.ejwf.2025.10.007
Maged S Alhammadi, Mohammed Sawady, Mona M Salah Fayed, Saleem Abdulrab, Nada O El Zawahry, Mahmoud Ahmed Fekry, Amwaj Yahya Hassan Alamer, Esam Halboub

Background: The present study assessed the performance of four prominent chatbots (ChatGPT-4o, Grok 3, Gemini Advanced, and Claude 3.7 Sonnet) in answering orthodontics- and dentofacial orthopedics-related multiple-choice questions (MCQs).

Methods: One hundred MCQs were prepared by three orthodontic consultants. These questions, each with four potential answers, covered basic and advanced orthodontic knowledge and clinical case scenarios. The chatbots' answers were assessed twice at a one-week interval. Three orthodontists' answers were reported once on a Google Form. Performance was measured as the percentage of correct answers, while consistency was measured as the McNemar test and Cohen's Kappa. A P ≤ 0.05 was considered significant.

Results: The chatbots' performance ranged from 72% to 84% and from 79% to 85% in the first and second rounds, respectively. Orthodontists' performances ranged from 71% to 84%. The highest intrachatbot consistency was observed for Grok 3 (McNemar P = 1, and Kappa = 0.793), while the lowest was for Gemini Advanced and ChatGPT-4o (McNemar P = 0.001 and 0.167, respectively, and Kappa = 0.490 each). The interchatbot consistencies showed variability over time and were significantly different between Grok 3 and Claude 3.7 Sonnet (McNemar P = 0.109, and Kappa = 0.677) in the first round and between Gemini Advanced and Claude 3.7 Sonnet (McNemar P = 0.344, and Kappa = 0.647) in the second round. The consistencies among the orthodontists and between the orthodontists and chatbots were highly variable.

Conclusions: The performance of the evaluated chatbots in answering MCQs in orthodontics and dentofacial orthopedics is still below expectations, although it was slightly better than that of orthodontists. Substantial inconsistencies existed among the chatbots, thus making them unsuitable for completely replacing existing educational methods and strongly suggesting that further improvement, continuous updating, and assessments are needed.

背景:本研究评估了四个著名的聊天机器人(chatgpt - 40、Grok 3、Gemini Advanced和Claude 3.7 Sonnet)在回答正畸和牙面矫形相关的多项选择题(mcq)方面的表现。方法:由3名正畸专科医生制作100份mcq。这些问题,每个问题有四个可能的答案,涵盖了基本和高级正畸知识和临床案例。每隔一周对聊天机器人的回答进行两次评估。在谷歌表格上报告了三名正畸医生的答案。表现是用正确答案的百分比来衡量的,而一致性是用麦克尼马尔测试和科恩的卡帕测试来衡量的。A P≤0.05被认为是显著的。结果:在第一轮和第二轮中,聊天机器人的表现分别在72%到84%和79%到85%之间。正畸医生的表现从71%到84%不等。Grok 3的腔内一致性最高(McNemar P = 1, Kappa = 0.793),而Gemini Advanced和chatgpt - 40的腔内一致性最低(McNemar P = 0.001, 0.167, Kappa = 0.490)。聊天机器人之间的一致性随时间而变化,在第一轮中Grok 3和Claude 3.7十四行诗(McNemar P = 0.109, Kappa = 0.677)和第二轮中Gemini Advanced和Claude 3.7十四行诗(McNemar P = 0.344, Kappa = 0.647)之间存在显著差异。正畸医生之间以及正畸医生和聊天机器人之间的一致性是高度可变的。结论:被评估的聊天机器人在正畸和牙面矫形中回答mcq的表现仍低于预期,但略好于正畸医生。聊天机器人之间存在很大的不一致性,因此它们不适合完全取代现有的教育方法,强烈建议进一步改进,持续更新和评估。
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引用次数: 0
68 - Dental VR for Clinical Education – Application in Bracket Bonding (DESSERT) 牙科VR在临床教育中的应用-托槽粘接(甜点)
IF 3.2 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-01 DOI: 10.1016/j.ejwf.2025.07.072
Kenko Jian-Hong Yu , Yu-Hsiang Chang , Tzu-Hsin Lee , Hasegawa Sumi , Yuan-Hou Chen

Background

Enhancing learning in dental education is essential, particularly for clinical procedures like bracket bonding, where traditional methods face challenges such as infection control and material waste.

Objectives

This study aimed to evaluate the effectiveness of integrating Virtual Reality (VR) into bracket bonding education to improve student engagement, streamline training, and enhance clinical skill development.

Methods

Thirty dental students from China Medical University participated in a one-hour lecture on bracket bonding techniques, followed by a VR-based bonding simulation. Teachers monitored activities in real-time, providing immediate feedback. At the semester’s end, students completed questionnaires to assess the course.

Results

Students showed improved accuracy and efficiency in bracket positioning and clinical practice. Feedback highlighted high satisfaction levels and provided insights for refining VR simulations. Teachers observed significant improvement in students’ clinical performance during the VR-based training.

Conclusions

VR-based bracket bonding training provided a controlled, infection-free learning environment that reduced material waste and improved clinical skills. This approach holds significant potential for broader implementation in dental education.
在牙科教育中加强学习是必不可少的,特别是在诸如托槽粘接等临床程序中,传统方法面临感染控制和材料浪费等挑战。目的探讨将虚拟现实(VR)技术整合到牙槽关系教育中,在提高学生参与度、简化培训流程、促进临床技能发展等方面的效果。方法30名中国医科大学牙科专业学生参加了1小时的托槽粘接技术讲座,然后进行了基于vr的粘接模拟。教师实时监控活动,提供即时反馈。学期结束时,学生们完成了对课程的评估问卷。结果学生在托槽定位的准确性和效率及临床实践中均有提高。反馈强调了高满意度,并为改进VR模拟提供了见解。教师观察到学生在vr培训期间临床表现有显著改善。结论基于svr的托槽粘接训练提供了一个可控、无感染的学习环境,减少了材料浪费,提高了临床技能。这种方法在牙科教育中具有广泛实施的重要潜力。
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引用次数: 0
69 - Dentin hypersensitivity after interproximal enamel reduction in patients treated with clear aligners: Desensitizing effect of diode laser vs sodium fluoride 用透明矫正器治疗近端间牙釉质复位后的牙本质过敏:二极管激光与氟化钠的脱敏效果
IF 3.2 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-01 DOI: 10.1016/j.ejwf.2025.07.073
Ludovica Nucci , Maria Giovanna Ferraioli , Adriana Fiori , Antonella De Simone , Fabrizia d'Apuzzo , Vincenzo Grassia

Background

Interproximal enamel reduction (IPR) is a common procedure in orthodontic treatment with clear aligners, but it may lead to dentin hypersensitivity (DH) and changes in gingival health.

Objective

This study evaluated dentin hypersensitivity and gingival health after IPR in patients treated with clear aligners and compared the desensitizing effect of laser diode versus sodium fluoride.

Methods

The study was a triple-blinded randomized controlled clinical trial. To be eligible for inclusion, patients had to respect for the following criteria: permanent dentition, good oral and general health. Previous history of hypersensitivity, enamel defects, cervical caries, periodontal disease, or pregnancy were excluded. A total of 45 patients with an orthodontic treatment plan including clear aligners and IPR (aged 14–63yrs) were randomly assigned to three groups: Group A (acidulated sodium fluoride gel: 0.33% NaF), Group B (diode laser: Soft Touch, 810 nm, 0,5W), and Group C (control, no treatment). In all groups, the response to air stimuli and the gingival indices were recorded before (T0) and immediately after IPR (T1), one week (T2), one month (T3), and three months post-treatment (T4). DH was assessed using a visual analog scale (VAS) by a blinded operator, while gingival health was evaluated using Silness and Löe Plaque and Gingivitis Indices.

Results

All groups showed an increase in DH immediately after IPR compared to baseline, which subsequently decreased at T2, T3, and T4. The laser group exhibited a statistically significant 10% reduction in DH, with rapid improvement one week post-treatment and sustained benefits over time. The gingival index improved or remained stable across all groups, with the laser group showing the most pronounced improvements. Moreover, the Plaque index was reduced in all groups.

Conclusion

The application of diode laser, after IPR, effectively reduced DH without adversely affecting gingival health. This finding supports the use of laser therapy to manage DH in orthodontic patients undergoing IPR.
近端间牙釉质还原(IPR)是正畸治疗中常用的一种方法,但它可能导致牙本质过敏(DH)和牙龈健康的变化。目的评价牙本质过敏和牙龈健康状况,并比较激光二极管和氟化钠的脱敏效果。方法采用三盲随机对照临床试验。为了有资格纳入,患者必须遵守以下标准:恒牙、口腔健康和一般健康。既往过敏史、牙釉质缺损史、宫颈龋病史、牙周病史或妊娠史均排除在外。采用含透明矫正器和IPR的正畸治疗方案的患者45例(年龄14 - 63岁),随机分为3组:A组(酸化氟化钠凝胶:0.33% NaF)、B组(二极管激光:软触,810 nm, 0.5 w)和C组(对照组,未治疗)。各组患者分别于治疗前(T0)、治疗后立即(T1)、治疗后1周(T2)、1个月(T3)、治疗后3个月(T4)记录空气刺激反应及牙龈指数。由盲法操作人员使用视觉模拟量表(VAS)评估DH,而使用Silness和Löe菌斑和牙龈炎指数评估牙龈健康状况。结果与基线相比,所有组在IPR后立即出现DH升高,随后在T2, T3和T4时下降。激光治疗组的DH降低了10%,在治疗后一周迅速改善,并随着时间的推移持续获益。所有组的牙龈指数都有所改善或保持稳定,其中激光组的改善最为明显。此外,各组斑块指数均有所降低。结论二极管激光在IPR后的应用可有效降低DH,且不影响牙龈健康。这一发现支持使用激光治疗来管理正畸患者的DH接受IPR。
{"title":"69 - Dentin hypersensitivity after interproximal enamel reduction in patients treated with clear aligners: Desensitizing effect of diode laser vs sodium fluoride","authors":"Ludovica Nucci ,&nbsp;Maria Giovanna Ferraioli ,&nbsp;Adriana Fiori ,&nbsp;Antonella De Simone ,&nbsp;Fabrizia d'Apuzzo ,&nbsp;Vincenzo Grassia","doi":"10.1016/j.ejwf.2025.07.073","DOIUrl":"10.1016/j.ejwf.2025.07.073","url":null,"abstract":"<div><h3>Background</h3><div>Interproximal enamel reduction (IPR) is a common procedure in orthodontic treatment with clear aligners, but it may lead to dentin hypersensitivity (DH) and changes in gingival health.</div></div><div><h3>Objective</h3><div>This study evaluated dentin hypersensitivity and gingival health after IPR in patients treated with clear aligners and compared the desensitizing effect of laser diode versus sodium fluoride.</div></div><div><h3>Methods</h3><div>The study was a triple-blinded randomized controlled clinical trial. To be eligible for inclusion, patients had to respect for the following criteria: permanent dentition, good oral and general health. Previous history of hypersensitivity, enamel defects, cervical caries, periodontal disease, or pregnancy were excluded. A total of 45 patients with an orthodontic treatment plan including clear aligners and IPR (aged 14–63yrs) were randomly assigned to three groups: Group A (acidulated sodium fluoride gel: 0.33% NaF), Group B (diode laser: Soft Touch, 810 nm, 0,5W), and Group C (control, no treatment). In all groups, the response to air stimuli and the gingival indices were recorded before (T0) and immediately after IPR (T1), one week (T2), one month (T3), and three months post-treatment (T4). DH was assessed using a visual analog scale (VAS) by a blinded operator, while gingival health was evaluated using Silness and Löe Plaque and Gingivitis Indices.</div></div><div><h3>Results</h3><div>All groups showed an increase in DH immediately after IPR compared to baseline, which subsequently decreased at T2, T3, and T4. The laser group exhibited a statistically significant 10% reduction in DH, with rapid improvement one week post-treatment and sustained benefits over time. The gingival index improved or remained stable across all groups, with the laser group showing the most pronounced improvements. Moreover, the Plaque index was reduced in all groups.</div></div><div><h3>Conclusion</h3><div>The application of diode laser, after IPR, effectively reduced DH without adversely affecting gingival health. This finding supports the use of laser therapy to manage DH in orthodontic patients undergoing IPR.</div></div>","PeriodicalId":43456,"journal":{"name":"Journal of the World Federation of Orthodontists","volume":"14 6","pages":"Page 422"},"PeriodicalIF":3.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145705201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
74 - Diagnostic accuracy of ChatGPT-4 in recommending immunohistochemistry panels for salivary gland tumours ChatGPT-4在推荐唾液腺肿瘤免疫组化检查中的诊断准确性
IF 3.2 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-01 DOI: 10.1016/j.ejwf.2025.07.078
Valentina Alvarez Silberberg , Maria Carolina Cuevas Nuñez , Rodrigo Diaz Castañeda , Alexandro Gudenschwager , Maria Fernandez-Figueras

Purpose

Salivary gland tumours pose a significant diagnostic challenge due to their histological diversity and overlapping pathological features. Immunohistochemistry (IHC) is a crucial tool in distinguishing these neoplasms, yet selecting the optimal IHC panel remains complex. Artificial intelligence (AI) applications, hold promise in improving diagnostic accuracy by recommending IHC markers. This study evaluates the diagnostic performance of ChatGPT-4 in recommending IHC markers for salivary gland tumours.

Methods

A free version of ChatGPT-4 was used to generate IHC panel recommendations for 21 salivary gland tumour types. A consensus panel of expert pathologists established reference IHC panels, serving as the gold standard for comparison. Chatbot responses were assessed using a structured scoring system measuring accuracy, completeness, and relevance. Cohen’s Kappa analysis quantified agreement between chatbot and pathologist recommendations. Sensitivity, specificity, and F1-scores evaluated diagnostic performance. Consistency across multiple chatbot queries was assessed using repeated measures ANOVA and Bland-Altman analysis. Performance was compared against a rule-based system following strict pathologist guidelines.

Results

The chatbot demonstrated moderate overall agreement (κ=0.53) with pathologists, with higher agreement for benign (κ=0.67) than malignant tumours (κ=0.40). Sensitivity was high (>0.80) for benign tumours but lower for malignant neoplasms. The chatbot frequently recommended unnecessary markers, reducing specificity (<0.50) for several malignancies. Stability analysis revealed variability in chatbot responses, particularly for complex tumour types. ChatGPT underperformed compared to the rule-based system, exhibiting higher rates of incorrect and missed markers.

Conclusion

AI-powered chatbots show potential in aiding IHC marker selection but currently lack the precision required for clinical implementation.
目的唾液腺肿瘤由于其组织多样性和重叠的病理特征,对诊断提出了重大挑战。免疫组化(IHC)是鉴别这些肿瘤的重要工具,但选择最佳的免疫组化组仍然很复杂。人工智能(AI)应用有望通过推荐免疫组化标记物来提高诊断准确性。本研究评估ChatGPT-4在推荐唾液腺肿瘤IHC标记物方面的诊断性能。方法使用ChatGPT-4免费版本生成21种唾液腺肿瘤类型的免疫组化推荐。由病理学专家组成的共识小组建立了参考免疫组化小组,作为比较的金标准。聊天机器人的回答使用一个结构化的评分系统来评估准确性、完整性和相关性。科恩的Kappa分析量化了聊天机器人和病理学家建议之间的一致性。敏感性、特异性和f1评分评估诊断性能。使用重复测量ANOVA和Bland-Altman分析评估多个聊天机器人查询的一致性。在严格的病理学指导下,将表现与基于规则的系统进行比较。结果聊天机器人与病理学家表现出中等程度的总体一致性(κ=0.53),对良性肿瘤(κ=0.67)的一致性高于恶性肿瘤(κ=0.40)。良性肿瘤的敏感性较高(>0.80),而恶性肿瘤的敏感性较低。聊天机器人经常推荐不必要的标记物,降低了几种恶性肿瘤的特异性(<0.50)。稳定性分析揭示了聊天机器人反应的可变性,特别是对于复杂的肿瘤类型。与基于规则的系统相比,ChatGPT表现不佳,显示出更高的不正确和遗漏标记率。结论人工智能聊天机器人在帮助免疫组化标志物选择方面具有潜力,但目前缺乏临床实施所需的精度。
{"title":"74 - Diagnostic accuracy of ChatGPT-4 in recommending immunohistochemistry panels for salivary gland tumours","authors":"Valentina Alvarez Silberberg ,&nbsp;Maria Carolina Cuevas Nuñez ,&nbsp;Rodrigo Diaz Castañeda ,&nbsp;Alexandro Gudenschwager ,&nbsp;Maria Fernandez-Figueras","doi":"10.1016/j.ejwf.2025.07.078","DOIUrl":"10.1016/j.ejwf.2025.07.078","url":null,"abstract":"<div><h3>Purpose</h3><div>Salivary gland tumours pose a significant diagnostic challenge due to their histological diversity and overlapping pathological features. Immunohistochemistry (IHC) is a crucial tool in distinguishing these neoplasms, yet selecting the optimal IHC panel remains complex. Artificial intelligence (AI) applications, hold promise in improving diagnostic accuracy by recommending IHC markers. This study evaluates the diagnostic performance of ChatGPT-4 in recommending IHC markers for salivary gland tumours.</div></div><div><h3>Methods</h3><div>A free version of ChatGPT-4 was used to generate IHC panel recommendations for 21 salivary gland tumour types. A consensus panel of expert pathologists established reference IHC panels, serving as the gold standard for comparison. Chatbot responses were assessed using a structured scoring system measuring accuracy, completeness, and relevance. Cohen’s Kappa analysis quantified agreement between chatbot and pathologist recommendations. Sensitivity, specificity, and F1-scores evaluated diagnostic performance. Consistency across multiple chatbot queries was assessed using repeated measures ANOVA and Bland-Altman analysis. Performance was compared against a rule-based system following strict pathologist guidelines.</div></div><div><h3>Results</h3><div>The chatbot demonstrated moderate overall agreement (κ=0.53) with pathologists, with higher agreement for benign (κ=0.67) than malignant tumours (κ=0.40). Sensitivity was high (&gt;0.80) for benign tumours but lower for malignant neoplasms. The chatbot frequently recommended unnecessary markers, reducing specificity (&lt;0.50) for several malignancies. Stability analysis revealed variability in chatbot responses, particularly for complex tumour types. ChatGPT underperformed compared to the rule-based system, exhibiting higher rates of incorrect and missed markers.</div></div><div><h3>Conclusion</h3><div>AI-powered chatbots show potential in aiding IHC marker selection but currently lack the precision required for clinical implementation.</div></div>","PeriodicalId":43456,"journal":{"name":"Journal of the World Federation of Orthodontists","volume":"14 6","pages":"Page 424"},"PeriodicalIF":3.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145705226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
75 - Diagnostic algorithm for localization and complexity assessment of impacted maxillary canines 上颌埋伏牙定位与复杂性评估的诊断算法
IF 3.2 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-01 DOI: 10.1016/j.ejwf.2025.07.079
Gunel Aliyeva , Sura Seyfullayeva , Alima Musayeva
Accurate diagnosis and evaluation of treatment complexity in maxillary canine impaction are essential for effective orthodontic planning. This study aimed to determine the prevalence and causes of canine impaction and to develop a diagnostic scoring system to assess treatment difficulty based on clinical and radiological criteria. A retrospective analysis of 11,704 patient records from the “Ortho-1” clinic over 35 years identified 255 cases of impaction of tooth 13 (2.17%) and 290 cases of tooth 23 (2.47%). Bilateral impaction was found in 94 cases (0.8%). Statistical analysis was performed in 44 patients who completed orthodontic treatment for bilateral impaction. A diagnostic index was developed based on: 1.⁠ ⁠Angulation to the midline (1–3 points), 2.⁠ ⁠Vertical depth relative to three occlusal reference lines (1–3 points), 3.⁠ ⁠Mesiodistal displacement (0–2 points), 4.⁠ ⁠Presence of complicating factors such as supernumerary teeth, odontomas, cysts, or rotations (0–1 point). The total score defines treatment difficulty: • 2–3 points: mild, • 4–5: moderate, • 6–9: severe. A statistically significant correlation was found between the total score and treatment duration. Higher scores were associated with increased treatment time and risk of complications. The proposed algorithm allows for more precise localization of impacted canines, individualized prognosis, and optimized treatment planning.
准确的诊断和评估上颌牙嵌塞的治疗复杂性对于制定有效的正畸计划至关重要。本研究旨在确定犬嵌塞的患病率和原因,并根据临床和放射学标准制定诊断评分系统来评估治疗难度。回顾性分析“ortho1”门诊35年来11704例患者的记录,发现13号牙嵌塞255例(2.17%),23号牙290例(2.47%)。双侧嵌塞94例(0.8%)。对44例完成双侧嵌塞正畸治疗的患者进行统计分析。建立了一种诊断指标:1。2.与中线成角(1-3点)相对于三条咬合参考线(1-3点)的垂直深度,4.中远端位移(0-2个点);存在复杂因素,如多牙、牙瘤、囊肿或旋转(0-1分)。总分定义治疗难度:•2-3分为轻度,•4-5分为中度,•6-9分为重度。总评分与治疗时间有显著的统计学相关性。得分越高,治疗时间越长,并发症风险越高。所提出的算法允许更精确地定位影响犬,个性化预后和优化治疗计划。
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引用次数: 0
60 - Considerations about Bisphenol-A release from orthodontic clear aligners: a systematic review 正畸透明矫正器释放双酚a的考虑:一项系统综述
IF 3.2 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-01 DOI: 10.1016/j.ejwf.2025.07.064
Diego Dos Santos Dias , Karla Dias Castro Dias , Natália dos Santos Dias , Álvaro Teixeira Mattos
The widespread adoption of clear orthodontic aligners has raised concerns regarding potential Bisphenol-A (BPA) release, a compound linked to endocrine disruption and adverse health outcomes. Despite preliminary in vitro studies suggesting trace BPA leaching from aligner materials, there remains a lack of comprehensive synthesis assessing the magnitude, clinical significance, and methodological consistency of these findings. This study aims to systematically evaluate and synthesize evidence on BPA release from clear orthodontic aligners. A systematic review was conducted in accordance with the PRISMA statement. Eligibility criteria included studies reporting BPA release from clear aligners only published within the last five years. Electronic databases including PubMed/MEDLINE and Cochrane Library were used with MeSH terms “Bisphenol A”, “Orthodontics” and “Orthodontic Appliances, Removable”. Study selection involved independent screening by two reviewers, with discrepancies resolved by consensus. Risk of bias was assessed using adapted quality appraisal tool for study selection, and data extraction captured study design, BPA quantification methods, exposure duration, and outcomes. The search results found five studies that met inclusion criteria, comprising four in vitro investigations and one ex vivo study. The studies consistently reported detectable BPA concentrations released over immersion periods of 24 hours to 10 days. Discussion emphasizes the need for standardized testing protocols to improve comparability. The evidence indicates that clear aligners can release trace amounts of BPA under laboratory and clinical conditions. However, due to limited clinical data, definitive conclusions regarding patient safety cannot be drawn. Further rigorous in vivo studies and harmonized laboratory protocols are warranted to assess exposure risk and long-term health implications.
清洁正畸矫正器的广泛使用引起了人们对潜在的双酚a (BPA)释放的担忧,BPA是一种与内分泌干扰和不良健康结果有关的化合物。尽管初步的体外研究表明从对准器材料中痕量的BPA浸出,但仍然缺乏对这些发现的规模、临床意义和方法学一致性的综合评估。本研究旨在系统评价和综合正畸矫正器中BPA释放的证据。根据PRISMA声明进行了系统审查。资格标准包括仅在最近五年内发表的关于透明矫正器释放BPA的研究。电子数据库包括PubMed/MEDLINE和Cochrane Library, MeSH检索词为“双酚A”、“Orthodontics”和“Orthodontic appliance, Removable”。研究选择由两位评论者进行独立筛选,差异通过共识解决。使用适用于研究选择的质量评价工具评估偏倚风险,数据提取捕获了研究设计、双酚a量化方法、暴露时间和结果。检索结果发现5项研究符合纳入标准,包括4项体外研究和1项离体研究。这些研究一致报告了浸泡24小时到10天后释放的可检测到的BPA浓度。讨论强调需要标准化的测试方案以提高可比性。有证据表明,在实验室和临床条件下,透明对准器可以释放微量的双酚a。然而,由于临床数据有限,无法得出关于患者安全的明确结论。有必要进一步进行严格的体内研究和统一的实验室规程,以评估接触风险和长期健康影响。
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引用次数: 0
31 - Assessing aesthetic outcomes of the surgery-first approach in skeletal class III patients 评估III类骨骼患者手术优先入路的美学效果
IF 3.2 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-01 DOI: 10.1016/j.ejwf.2025.07.035
Arthur Cunha , Tainá Manso , Jorge Faber , Flavia Artese , José Augusto Mendes Miguel
Despite the growing interest in the Surgery-First Approach (SFA), there is insufficient scientific evidence to compare the facial aesthetic outcomes of SFA with the Conventional Surgery Approach (CSA), and no consensus on whether one technique delivers better results after treatment. Consequently, this retrospective study aimed to evaluate aesthetic perception in patients treated with CSA and SFA. 34 patients were allocated into two groups of surgery protocol (CSA=16; SFA=18) and each group were matched according to skeletal discrepancy. The evaluators were divided into three categories (n=23 each): (1) oral and maxillofacial surgeons, (2) orthodontists and (3) laypeople. Profile images before surgery (T1) and after orthodontic-surgical treatment (T2) were analyzed using a 5-point Likert scale. Then, participants answered the following question: “Which surgical technique was used? SFA or CSA? Spearman's correlation coefficient, Friedman, and Kappa tests were applied to examine correlations between variables (p<0.05). One-way ANOVA and independent t-tests compared aesthetic perception scores between evaluators. A strong positive correlation was observed between surgeons and orthodontists (r=0.86; p<0.001), while the correlation between laypeople and specialists was weaker (r=0.48; p=0.03; r=0.55; p=0.01). There was no statistically significant difference between the scores regarding patients' aesthetic perception given by each groups of evaluators (>0.05) and separately (>0.05). When Kappa test was used regarding the type of surgical protocol performed the results reveals an extremely low agreement between the evaluators as indicated by a low Kappa value (κ=0.007). This study demonstrated that there were no noticeable differences in the aesthetics of the facial profile of Class III patients between the SFA and CSA. Regardless of the level of training of the evaluators, it was not possible to differentiate the surgical technique used.
尽管人们对手术优先入路(SFA)越来越感兴趣,但没有足够的科学证据来比较SFA和传统手术入路(CSA)的面部美学结果,并且对于哪种技术在治疗后的效果更好也没有共识。因此,本回顾性研究旨在评估CSA和SFA治疗患者的美感。将34例患者分为两组手术方案(CSA=16, SFA=18),根据骨骼差异进行匹配。评估者分为三类(各23人):(1)口腔颌面外科医生;(2)正畸医生;(3)非专业人员。采用5点Likert量表分析手术前(T1)和正畸手术治疗后(T2)的侧像。然后,参与者回答以下问题:“使用了哪种手术技术?”SFA还是CSA?采用Spearman相关系数、Friedman和Kappa检验检验变量之间的相关性(p<0.05)。单因素方差分析和独立t检验比较了评价者之间的审美知觉得分。外科医师与正畸医师之间存在较强的正相关(r=0.86; p<0.001),外行人与专科医师之间存在较弱的相关性(r=0.48; p=0.03; r=0.55; p=0.01)。各组评价者对患者的美感评分(>0.05)与单独评分(>0.05)比较,差异无统计学意义。当Kappa试验用于评估所执行的手术方案类型时,结果显示评估者之间的一致性极低,Kappa值很低(κ=0.007)。本研究表明,在SFA和CSA之间,III类患者的面部轮廓美学没有明显差异。无论评估人员的培训水平如何,都不可能区分所使用的手术技术。
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引用次数: 0
32 - Assessment of change in enamel color and surface hardness following the use of ICON resin infiltration and remineralizing agent: An in vitro study 使用ICON树脂浸润和再矿化剂后牙釉质颜色和表面硬度变化的评估:一项体外研究
IF 3.2 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-01 DOI: 10.1016/j.ejwf.2025.07.036
Naif Almosa , Khalid Alaman , Fares Alkhudairi , Muhannad Alhaqbani , Mohammed Alshalawi , Rahaf Zawawi
Dental enamel is a highly mineralized tissue with a well-packed crystalline structure. Orthodontic appliances act as stagnation areas that can become households where dental plaque accumulates, disrupting the typical mineral exchange between the dental enamel and oral fluids, potentially leading to the demineralization of enamel and the development of subsurface porous areas referred to as white spot lesions. This study aimed to evaluate the change in enamel color and surface micro-hardness fol- lowing the use of resin-infiltration concept material (ICON) and casein phosphopeptide-amorphous calcium fluoride phosphate (CPP-ACFP) remineralizing agent. Fifty-four extracted human third molars were collected and randomly divided into three groups: group A: control with no surface treatment; group B: treated using ICON; and group C: treated using CPP-ACFP. The change in color and micro-hardness of the enamel surface were measured using spectrophotometer and Vickers hardness number, respectively. The measurements were taken at three timelines; baseline (BL), after demineralization (DM), and after surface treatment (TX). The three groups showed no significant differences in enamel color change after demineralization (p < 0.05). However, after surface treatment in relation to the baseline, groups B and C had a significant increase in color change compared to the control group (p < 0.05), and group B showed a statistically significant increase in enamel color changes compared to group C. Additionally, all groups exhibited a significant reduction in enamel micro-hardness after demineralization in comparison to their baseline (p < 0.05). Group C showed a significant increase in micro-hardness after surface treatment compared to groups A and B (p < 0.05), while group B showed a significant decrease in enamel micro-hardness compared to groups A and C (p < 0.05). These findings suggest that teeth treated with CPP-amorphous calcium fluoride phos- phate (CPP-ACFP) show a significant improvement in enamel surface color after demineralization compared to the teeth treated with resin infiltration (ICON) and the non-treated teeth. Additionally, enamel surfaces treated with CPP-ACFP show significant enamel hardness regaining, while resin infiltration (ICON) compromises enamel surface hardness.
牙釉质是一种高度矿化的组织,具有良好的晶体结构。正畸矫形器作为一个停滞区域,可以成为牙菌斑积聚的家庭,破坏牙釉质和口腔液体之间典型的矿物质交换,潜在地导致牙釉质脱矿和表面下多孔区域的发展,即白斑病变。本研究旨在评价树脂渗透概念材料(ICON)和酪蛋白磷酸肽-无定形氟化钙磷酸盐(CPP-ACFP)再矿剂对牙釉质颜色和表面显微硬度的影响。收集拔除的人第三磨牙54颗,随机分为3组:A组:对照组,不作表面处理;B组:ICON治疗;C组:用CPP-ACFP治疗。分别用分光光度计和维氏硬度值测定牙釉质表面的颜色变化和显微硬度。测量是在三个时间轴上进行的;基线(BL)、脱矿后(DM)和表面处理后(TX)。三组脱矿后牙釉质颜色变化差异无统计学意义(p < 0.05)。但表面处理后,B组和C组牙釉质颜色变化较对照组显著增加(p < 0.05), B组牙釉质颜色变化较C组显著增加(p < 0.05)。各组牙釉质脱矿后显微硬度较基线均显著降低(p < 0.05)。表面处理后,C组牙釉质显微硬度较a、B组显著升高(p < 0.05), B组牙釉质显微硬度较a、C组显著降低(p < 0.05)。结果表明,cpp -非晶态氟化磷酸钙(CPP-ACFP)处理后的牙釉质脱矿后表面颜色明显改善,优于树脂渗透处理(ICON)和未处理的牙釉质表面颜色。此外,CPP-ACFP处理的牙釉质表面显示出明显的牙釉质硬度恢复,而树脂渗透(ICON)会损害牙釉质表面硬度。
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引用次数: 0
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Journal of the World Federation of Orthodontists
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