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Retrospective Analysis of Demographic and Laboratory Data of Patients with Hepatocellular Carcinoma: Single Center Experience 肝细胞癌患者人口统计学和实验室数据的回顾性分析:单中心经验
Pub Date : 1900-01-01 DOI: 10.5505/AOT.2019.69672
M. Bardakci, Y. Ergun, K. Yalcin
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引用次数: 1
Real-life analysis of immunotherapy as the second or later lines treatment in patients with metastatic non-small cell lung cancer 免疫治疗作为转移性非小细胞肺癌患者的二线或二线治疗的现实分析
Pub Date : 1900-01-01 DOI: 10.5505/aot.2021.26576
Sabin Göktaş Aydın, Ö. Açıkgöz, Yasin Kutlu, A. Bilici, J. Hamdard, Ö. Ölmez, Özcan Yıldız
{"title":"Real-life analysis of immunotherapy as the second or later lines treatment in patients with metastatic non-small cell lung cancer","authors":"Sabin Göktaş Aydın, Ö. Açıkgöz, Yasin Kutlu, A. Bilici, J. Hamdard, Ö. Ölmez, Özcan Yıldız","doi":"10.5505/aot.2021.26576","DOIUrl":"https://doi.org/10.5505/aot.2021.26576","url":null,"abstract":"","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"111 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132186840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of the COVID-19 pandemic on head and neck cancer practice - tertiary health care center experience COVID-19大流行对头颈癌实践的影响——三级卫生保健中心的经验
Pub Date : 1900-01-01 DOI: 10.5505/aot.2021.46762
A. Duran, A. Ant, Tuncay Tunccan, C. Kılıç, Elif Akyol Şen, Burcu Vural, Samet Özlügedik
{"title":"The impact of the COVID-19 pandemic on head and neck cancer practice - tertiary health care center experience","authors":"A. Duran, A. Ant, Tuncay Tunccan, C. Kılıç, Elif Akyol Şen, Burcu Vural, Samet Özlügedik","doi":"10.5505/aot.2021.46762","DOIUrl":"https://doi.org/10.5505/aot.2021.46762","url":null,"abstract":"","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129567749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Survival of a Patient with Anaplastic Thyroid Cancer Following Neoadjuvant Chemotherapy Regimen ‘cisplatin doxorubicin’ And Surgery - A Case Report 新辅助化疗方案“顺铂-阿霉素”和手术后间变性甲状腺癌患者的生存- 1例报告
Pub Date : 1900-01-01 DOI: 10.5505/AOT.2020.49932
G. Akgul, E. Esen, I. Erturk, M. Turan, M. Akıncı
{"title":"Survival of a Patient with Anaplastic Thyroid Cancer Following Neoadjuvant Chemotherapy Regimen ‘cisplatin doxorubicin’ And Surgery - A Case Report","authors":"G. Akgul, E. Esen, I. Erturk, M. Turan, M. Akıncı","doi":"10.5505/AOT.2020.49932","DOIUrl":"https://doi.org/10.5505/AOT.2020.49932","url":null,"abstract":"","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"479 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132219185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship Between Staging FDG PET/CT Findings and Distribution of Metastatic Sites in Metastatic Breast Cancer 转移性乳腺癌FDG /CT分期与转移部位分布的关系
Pub Date : 1900-01-01 DOI: 10.5505/aot.2023.40360
Bedriye Busra Demirel, S. Gülbahar Ateş, Hüseyin Emre Tosun, Süleyman Aksu, Gülin Uçmak
Introduction: We aimed to investigate the relationship between staging FGD PET/CT findings and metastasis distribution and histopathological features of primary tumor in patients with metastatic breast cancer at diagnosis time. Materials and Methods: Eighty patients with breast cancer who underwent F-18 FDG PET/CT for staging were included. The patients with newly diagnosed metastatic disease were included. Age and histopathological features of the primary tumor were recorded. The distant metastases sites, the numbers of metastasis and metastatic axillary/non-axillary lymph nodes were reviewed from PET/CT. The maximum standardized uptake(SUVmax) values were measured. Results: All patients(n:80,mean age 58.0±14.4) had invasive breast carcinoma. Age was significantly related to the presence of lung metastases(p=0.006, mean ages 54y vs 64y).Only liver metastasis had a significant relationship with primary tumor SUVmax values and tumor molecular profile. The patients with HR+/HER2-(7/60 patients, 11.7%) had relatively less liver metastasis than with the other subtypes (9/20patients, 45%). There were significant associations between SUVmax of axillary lymph node(p=0.02), primary tumor(p=0.001), liver metastasis(p=0.02) and tumor subtypes. The numbers of distant metastasis were related with the numbers of axillary lymph node metastasis(p=0.02) and the highest SUVmax of distant metastasis(p=0.001). Discussion: Accurate detection of distant metastases in breast cancer at the time of diagnosis is of great importance in terms of treatment planning and prognosis of the disease. FDG PET/CT is a very reliable modality in determining distant metastasis and their distribution, and as a result of our study, we suggest that PET/CT findings can predict factors with prognostic importance.
前言:我们旨在探讨转移性乳腺癌患者诊断时FGD分期PET/CT表现与原发肿瘤转移分布及组织病理学特征的关系。材料与方法:80例接受F-18 FDG PET/CT分期的乳腺癌患者。包括新诊断的转移性疾病患者。记录原发肿瘤的年龄和组织病理学特征。PET/CT检查远处转移部位、转移数量及腋窝/非腋窝淋巴结转移情况。测量了最大标准化摄取(SUVmax)值。结果:80例患者均为浸润性乳腺癌,平均年龄58.0±14.4岁。年龄与肺转移的存在显著相关(p=0.006,平均年龄54y vs 64y)。只有肝转移与原发肿瘤SUVmax值和肿瘤分子谱有显著关系。HR+/HER2-亚型患者(7/60例,11.7%)的肝转移率低于其他亚型患者(9/20例,45%)。腋窝淋巴结SUVmax (p=0.02)、原发肿瘤(p=0.001)、肝转移(p=0.02)与肿瘤亚型有显著相关性。远处转移数与腋窝淋巴结转移数相关(p=0.02),远处转移SUVmax最高(p=0.001)。讨论:在诊断时准确发现乳腺癌远处转移对疾病的治疗计划和预后具有重要意义。FDG PET/CT是确定远处转移及其分布的一种非常可靠的方式,根据我们的研究,我们认为PET/CT的结果可以预测具有预后重要性的因素。
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引用次数: 0
Ultrasonography Education in General Surgery Resident Training Program and Evaluation of Level of Utrasonography Learning Curves of General Surgery Residents 普外科住院医师超声教育培训方案及普外科住院医师超声学习曲线水平评价
Pub Date : 1900-01-01 DOI: 10.5505/aot.2019.49260
Ş. Balas, Seray Akcalar, K. Yılmaz, M. Akıncı, S. Tokgöz, M. Saydam, M. Akkoca, O. Ergun, H. Karabacak, I. Tatar, B. Hekimoğlu
INTRODUCTION: Ultrasonography (USG) is an imaging technique that enables real-time evaluation of visceral organs via versatile utilization possibilities. Besides diagnosis and treatment contributions, it is crucial in patient follow-up and it also gives an opportunity of intraoperative usage. This study aims to discuss a model of USG training which should be included in the specialist training program and to evaluate the effectiveness of the examination applied to resident doctors and to evaluate the learning curve on patients with thyroid nodule, bile stone stone and intraabdominal free fluid. METHODS: After the ethics committee approving, practical, theoretical training and per-patient usage of USG was given by the radiologist as a part of the clinical training. After the training, four surgical assistants selected from different years of residenties were practiced on a patient basis, under possesion of the radiologist. A twostage examination system was determined and the evaluations of the surgical residents were made by the
简介:超声(USG)是一种成像技术,通过多种用途的可能性,使实时评估内脏器官。除了诊断和治疗的贡献外,它对患者的随访至关重要,也为术中应用提供了机会。本研究旨在探讨一种应纳入专科培训计划的USG培训模式,评估USG考试应用于住院医师的有效性,评估甲状腺结节、胆结石、腹内游离液患者的学习曲线。方法:经伦理委员会批准后,放射科医师将USG的实践、理论培训和每位患者使用情况作为临床培训的一部分。培训结束后,在放射科医生的指导下,从不同年限的住院医师中挑选出四名外科助理,以病人为基础进行实习。确定了两阶段的考核制度,并对外科住院医师进行了评估
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引用次数: 0
The Predictive Value of FDG PET/CT in the Evaluation of Bone Marrow Involvement in Lymphoma Patients FDG PET/CT对淋巴瘤患者骨髓受累的预测价值
Pub Date : 1900-01-01 DOI: 10.5505/aot.2022.39259
B. Sağlam, A. Yıldız, B. Kaya, Kultigin Türkmen
Introduction: The aim of the current study was to determine the role of PET-CT in the evaluation of bone marrow (BM) involvement during initial staging in patients with newly diagnosed lymphoma. Methods: A retrospective analysis was made of 104 patients who were admitted to our Hematology Department between January 2010 and September 2016 and were diagnosed with lymphoma. Patients were classified as Hodgkin (HL) and Non-Hodgkin Lyphoma (NHL). NHL patients were evaluated in two subgroups as aggressive and indolent. Results: The patients comprised 54 (51.9%) males and 50 (48.1%) females and were classified as 24 patients with HL and 80 with NHL. BM biopsy showed BM involvement in 40 patients (38.5%) and there was no pathological finding in 64 (61.5%) patients. BM involvement was detected on PET-CT in 41 (39.4%) of the whole patient group, of which 26 (63.4%) cases had diffuse infiltration and the remaining 15 (36.6%) cases had patchy infiltration. For all lymphoma patients, sensitivity of PET-CT was 80% and specificity was 85.9%. Sensitivity and specificity of PET-CT was 92.3% and 81.8% for HL patients and 74.1% and 86.8% for NHL patients, respectively. For only aggressive NHL patients, PET-CT sensitivity was 81.8% and specificity was 87.75%. Discussion and Conclusion: PET-CT is an effective method for assessing BM involvement with a higher sensitivity especially for HL and aggressive NHL patients in detecting patchy involvement. The fact that it is non-invasive and easy to apply may support that it can be used instead of BM biopsy.
当前研究的目的是确定PET-CT在新诊断淋巴瘤患者初始阶段评估骨髓(BM)累及的作用。方法:对2010年1月至2016年9月我院血液科收治的104例淋巴瘤患者进行回顾性分析。患者分为霍奇金淋巴瘤(HL)和非霍奇金淋巴瘤(NHL)。NHL患者分为两个亚组,分别为侵袭性和惰性。结果:男性54例(51.9%),女性50例(48.1%),其中HL 24例,NHL 80例。BM活检显示40例(38.5%)患者BM受累,64例(61.5%)患者未见病理发现。全组41例(39.4%)患者PET-CT检出BM受累,其中弥漫性浸润26例(63.4%),斑片状浸润15例(36.6%)。对于所有淋巴瘤患者,PET-CT的敏感性为80%,特异性为85.9%。PET-CT对HL患者的敏感性和特异性分别为92.3%和81.8%,对NHL患者的敏感性和特异性分别为74.1%和86.8%。仅对于侵袭性NHL患者,PET-CT敏感性为81.8%,特异性为87.75%。讨论与结论:PET-CT是评估脑转移累及的有效方法,尤其对HL和侵袭性NHL患者具有较高的敏感性。事实上,它是非侵入性的,易于应用,可能支持它可以代替BM活检。
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引用次数: 0
The Relation Between Tumor and Axillary Lymph Node SUV Values with the Presence of Distant Metastases in Staging F18 FDG PET/CT in Breast Cancer F18 FDG PET/CT分期乳腺癌肿瘤及腋窝淋巴结SUV值与远处转移的关系
Pub Date : 1900-01-01 DOI: 10.5505/aot.2022.75688
Bedriye Busra Demirel, Hüseyin Emre Tosun, Gülin Uçmak
Introduction: We aimed to investigate the relation between primary tumor and axillary lymph node maximum standardized uptake values (SUVmax) with the presence of distant metastases at initial staging of breast cancer. Materials and Methods: Fifty-seven women who were referred to our clinic for staging positron emission tomography/computed tomography (PET/CT) with diagnosis of breast cancer were included in the study. Immunohistochemical (IHC) features of the primary tumor [hormone receptor (HR), human epidermal growth factor receptor type-2 (HER2), Ki67 index] were reviewed retrospectively. All patients’ HR status was positive and HER2 status was negative. Primary tumor SUVmax (Tmax) and axillary lymph node SUVmax (Nmax) values and primary tumor-to-axillary lymph node (T/N) ratios were calculated in PET/CT. Patients were divided into two groups as metastatic and non-metastatic according to PET/CT findings. The differences between groups in terms of age, Ki67 index and SUV values were statistically analyzed. Results: The mean age of the patients was 52±14.4 (range 25-79 years). According to PET/CT findings, the patients were divided in two groups, 57% metastatic (n = 33) and 43% non-metastatic (n = 24). While no statistically significant difference was observed between the two groups in terms of age, Ki67 index and Tmax averages, statistically significant differences were found between Nmax values (p <0.001) and T/N ratios (p=0.001). Cut-off value in association with distant metastasis was 7,8 for Nmax value and 8,5 for T/N ratio on ROC curve analysis. Discussion: Accurate staging is important in terms of treatment plan and prediction of disease prognosis in breast cancer. In our study, it was thought that the difference in Nmax values and T/N ratios, independent of Tmax values, could be a determinant in terms of the overlooked and possible early metastatic disease indicator in the patient group without known distant metastasis.
简介:我们的目的是探讨原发性肿瘤和腋窝淋巴结最大标准化摄取值(SUVmax)与乳腺癌早期远处转移的关系。材料和方法:本研究纳入了57名到我们诊所进行分期正电子发射断层扫描/计算机断层扫描(PET/CT)诊断为乳腺癌的妇女。回顾性回顾原发性肿瘤的免疫组化(IHC)特征[激素受体(HR)、人表皮生长因子受体2型(HER2)、Ki67指数]。所有患者HR状态均为阳性,HER2状态均为阴性。PET/CT计算原发肿瘤SUVmax (Tmax)、腋窝淋巴结SUVmax (Nmax)值及原发肿瘤与腋窝淋巴结(T/N)比值。根据PET/CT表现将患者分为转移性和非转移性两组。统计学分析各组年龄、Ki67指数、SUV值的差异。结果:患者平均年龄52±14.4岁(25 ~ 79岁)。根据PET/CT表现将患者分为两组,57%转移(n = 33)和43%非转移(n = 24)。两组患者的年龄、Ki67指数和Tmax平均值差异无统计学意义,但Nmax值和T/N比值差异有统计学意义(p <0.001)。ROC曲线分析的Nmax值和T/N比的临界值分别为7,8和8,5,与远处转移相关。讨论:准确分期对乳腺癌的治疗方案和预测疾病预后具有重要意义。在我们的研究中,我们认为Nmax值和T/N比值的差异,独立于Tmax值,可能是在没有已知远处转移的患者组中被忽视和可能的早期转移性疾病指标的决定因素。
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引用次数: 0
Outcomes of prophylactic intramedullary fixation for benign bone lesions 预防性髓内固定治疗良性骨病变的疗效
Pub Date : 1900-01-01 DOI: 10.5505/aot.2019.64325
Çağrı Neyişci, Y. Erdem, A. Bilekli
Background: In this study, we aimed to present the results of patients who underwent prophylactic intramedullary fixation for benign bone lesions. Materials and Methods: Twenty-two patients who underwent curettage, grafting and prophylactic intramedullary fixation for benign bone lesions between 2008 and 2017 were included in this study. The lesions were examined according to the Mirels’ classification in the preoperative period and the pathological fracture risk was determined. Curettage, allografting and intramedullary fixation were used in the treatment of all patients. In the follow-up examination, patients were evaluated according to the range of motion, pain, radiological appearance of the lesion and the implant. Results: The mean age of the patients was 24.8 (7-38) years. The mean follow-up period was 35.8 (13-80) months. The initial complaint of twenty-one patients was pain which caused loss of function in two patients. One patient with pathological humerus fracture was admitted with acute pain and loss of function. He was followed conservatively for two months, then prophylactic surgery was performed. The mean Mirels’ score of the patients was 9.3 (9-10). In the follow-up examination, the range of motion was full in all patients. The mean VAS score decreased from 8.09 to 2.54 postoperatively. Conclusions: We conclude that prophylactic fixation for benign bone lesions which has 9 or more Mirels’ score reduces the risk of impending pathological fractures, reduces VAS scores, and also prevents loss of function and enables to return normal activity earlier.
背景:在这项研究中,我们的目的是报告接受预防性髓内固定治疗良性骨病变的患者的结果。材料与方法:本研究纳入2008 - 2017年间22例行刮除、移植及预防性髓内固定治疗良性骨病变的患者。术前按Mirels分级检查病变,确定病理性骨折风险。所有患者均采用刮除、同种异体移植和髓内固定治疗。在随访检查中,根据患者的活动范围、疼痛、病变和植入物的影像学表现对患者进行评估。结果:患者平均年龄24.8岁(7-38岁)。平均随访时间为35.8(13 ~ 80)个月。21例患者最初的主诉是疼痛,其中2例患者因疼痛导致功能丧失。一例病理性肱骨骨折患者因急性疼痛和功能丧失而入院。保守随访2个月后行预防性手术。患者的平均Mirels评分为9.3(9-10分)。在随访检查中,所有患者的活动范围都很充分。VAS评分由8.09降至2.54。结论:对于Mirels评分为9分或以上的良性骨病变,预防性固定可降低病理性骨折发生的风险,降低VAS评分,并可防止功能丧失,使患者早日恢复正常活动。
{"title":"Outcomes of prophylactic intramedullary fixation for benign bone lesions","authors":"Çağrı Neyişci, Y. Erdem, A. Bilekli","doi":"10.5505/aot.2019.64325","DOIUrl":"https://doi.org/10.5505/aot.2019.64325","url":null,"abstract":"Background: In this study, we aimed to present the results of patients who underwent prophylactic intramedullary fixation for benign bone lesions. Materials and Methods: Twenty-two patients who underwent curettage, grafting and prophylactic intramedullary fixation for benign bone lesions between 2008 and 2017 were included in this study. The lesions were examined according to the Mirels’ classification in the preoperative period and the pathological fracture risk was determined. Curettage, allografting and intramedullary fixation were used in the treatment of all patients. In the follow-up examination, patients were evaluated according to the range of motion, pain, radiological appearance of the lesion and the implant. Results: The mean age of the patients was 24.8 (7-38) years. The mean follow-up period was 35.8 (13-80) months. The initial complaint of twenty-one patients was pain which caused loss of function in two patients. One patient with pathological humerus fracture was admitted with acute pain and loss of function. He was followed conservatively for two months, then prophylactic surgery was performed. The mean Mirels’ score of the patients was 9.3 (9-10). In the follow-up examination, the range of motion was full in all patients. The mean VAS score decreased from 8.09 to 2.54 postoperatively. Conclusions: We conclude that prophylactic fixation for benign bone lesions which has 9 or more Mirels’ score reduces the risk of impending pathological fractures, reduces VAS scores, and also prevents loss of function and enables to return normal activity earlier.","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116214147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simultaneous Evaluation of Serum Immunofixation Electrophoresis and Serum Free Light Chain Measurements Used in the Diagnosis of Monoclonal Gammopathy and Smoldering Multiple Myeloma of Uncertain Significance in the Presence of Risk Factors 同时评价血清免疫固定电泳和血清游离轻链测定在单克隆γ病和阴燃性多发性骨髓瘤诊断中的意义不确定的危险因素
Pub Date : 1900-01-01 DOI: 10.5505/aot.2023.32650
İrem Öner, Fatih Saçkan, A. Ünal
{"title":"Simultaneous Evaluation of Serum Immunofixation Electrophoresis and Serum Free Light Chain Measurements Used in the Diagnosis of Monoclonal Gammopathy and Smoldering Multiple Myeloma of Uncertain Significance in the Presence of Risk Factors","authors":"İrem Öner, Fatih Saçkan, A. Ünal","doi":"10.5505/aot.2023.32650","DOIUrl":"https://doi.org/10.5505/aot.2023.32650","url":null,"abstract":"","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125215349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Acta Oncologica Turcica
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