The Clinical Pharmacy Congress 2022 marked its 11th birthday, celebrating the return to normality after the pandemic with the delivery of over 250 educational sessions by industry experts over two days, to enhance the professional and personal development of attendees. Joy Ogden covers some highlights of the conference on thought‐provoking subjects such as risks of dementia with antimuscarinics and sessions on clinical priorities in epilepsy and headache.
{"title":"Clinical Pharmacy Congress 2022","authors":"","doi":"10.1002/pnp.781","DOIUrl":"https://doi.org/10.1002/pnp.781","url":null,"abstract":"The Clinical Pharmacy Congress 2022 marked its 11th birthday, celebrating the return to normality after the pandemic with the delivery of over 250 educational sessions by industry experts over two days, to enhance the professional and personal development of attendees. Joy Ogden covers some highlights of the conference on thought‐provoking subjects such as risks of dementia with antimuscarinics and sessions on clinical priorities in epilepsy and headache.","PeriodicalId":43913,"journal":{"name":"Progress in Neurology and Psychiatry","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45263005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neutropenia is a well‐known adverse side‐effect of clozapine that can also be seen with other atypical antipsychotics. In this article the authors discuss a patient who experienced neutropenia with clozapine and who subsequently redeveloped neutropenia with aripiprazole after a short trial. The case illustrates that close monitoring and caution is advisable when trialing patients on any further antipsychotics after a neutropenic event with clozapine.
{"title":"Clozapine and aripiprazole‐induced neutropenia","authors":"Stephanie Vel En Tial, M. Dixon","doi":"10.1002/pnp.774","DOIUrl":"https://doi.org/10.1002/pnp.774","url":null,"abstract":"Neutropenia is a well‐known adverse side‐effect of clozapine that can also be seen with other atypical antipsychotics. In this article the authors discuss a patient who experienced neutropenia with clozapine and who subsequently redeveloped neutropenia with aripiprazole after a short trial. The case illustrates that close monitoring and caution is advisable when trialing patients on any further antipsychotics after a neutropenic event with clozapine.","PeriodicalId":43913,"journal":{"name":"Progress in Neurology and Psychiatry","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48882946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Charfi, Salma Abid, N. Farhat, O. Elleuch, Saoussen Daoud, M. Dammak, S. Omri, J. B. Thabet, M. M. Bouali, C. Mhiri, Mohamed Mâalej
Psychiatric comorbidities are underestimated in epilepsy. Here the authors assess the prevalence of psychiatric comorbidities in a cohort of patients with epilepsy in an outpatient neurology unit in Habib Bourguiba Hospital, Tunisia, and identify the sociodemographic and clinical factors associated with the presence of these psychiatric disorders in this patient sample. The results highlight that particular attention should be paid to such patients as part of a global biopsychosocial approach.
{"title":"Psychiatric comorbidities in epilepsy patients: results of a Tunisian study","authors":"N. Charfi, Salma Abid, N. Farhat, O. Elleuch, Saoussen Daoud, M. Dammak, S. Omri, J. B. Thabet, M. M. Bouali, C. Mhiri, Mohamed Mâalej","doi":"10.1002/pnp.778","DOIUrl":"https://doi.org/10.1002/pnp.778","url":null,"abstract":"Psychiatric comorbidities are underestimated in epilepsy. Here the authors assess the prevalence of psychiatric comorbidities in a cohort of patients with epilepsy in an outpatient neurology unit in Habib Bourguiba Hospital, Tunisia, and identify the sociodemographic and clinical factors associated with the presence of these psychiatric disorders in this patient sample. The results highlight that particular attention should be paid to such patients as part of a global biopsychosocial approach.","PeriodicalId":43913,"journal":{"name":"Progress in Neurology and Psychiatry","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45822913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Psychiatric comorbidities are common in epilepsy. Common conditions such as depression and anxiety, and neurodevelopmental conditions ADHD and autism are also more prevalent in people with epilepsy. This article discusses a girl with a background of controlled epilepsy who was referred to the paediatric psychiatry clinic. It demonstrates a clear need for joint working between neurologists and psychiatric services to optimise the quality of life of such individuals.
{"title":"The crying child and dacrystic seizures: a diagnostic conundrum","authors":"A. Datta, S. Chakrabarti","doi":"10.1002/pnp.773","DOIUrl":"https://doi.org/10.1002/pnp.773","url":null,"abstract":"Psychiatric comorbidities are common in epilepsy. Common conditions such as depression and anxiety, and neurodevelopmental conditions ADHD and autism are also more prevalent in people with epilepsy. This article discusses a girl with a background of controlled epilepsy who was referred to the paediatric psychiatry clinic. It demonstrates a clear need for joint working between neurologists and psychiatric services to optimise the quality of life of such individuals.","PeriodicalId":43913,"journal":{"name":"Progress in Neurology and Psychiatry","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42162292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Despite the panoply of clinical assessment and neuroimaging modalities at the disposal of clinicians today, the diagnosis of neurodegenerative disorders may still prove challenging, particularly in the early stages, because of the subtlety of early changes and/or their overlap with (so‐called) psychiatric disorders. A case illustrating these difficulties is presented, in which long‐term follow‐up proved to be the most important investigation to establish the correct diagnosis.
{"title":"The neurology ‐ psychiatry interface: variations on a diagnostic theme","authors":"A. Larner","doi":"10.1002/pnp.776","DOIUrl":"https://doi.org/10.1002/pnp.776","url":null,"abstract":"Despite the panoply of clinical assessment and neuroimaging modalities at the disposal of clinicians today, the diagnosis of neurodegenerative disorders may still prove challenging, particularly in the early stages, because of the subtlety of early changes and/or their overlap with (so‐called) psychiatric disorders. A case illustrating these difficulties is presented, in which long‐term follow‐up proved to be the most important investigation to establish the correct diagnosis.","PeriodicalId":43913,"journal":{"name":"Progress in Neurology and Psychiatry","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46216625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Priyanka Chohan, Mark Dashwood, George Theodoulou, Hannah C. Reed, T. Kuruvilla
Blood‐based biomarkers for identifying Alzheimer's disease (AD) pathology have been of considerable interest over the past decade and can offer a significant advantage over the currently available and validated cerebrospinal fluid and positron emission tomography biomarkers in terms of cost, invasiveness and accessibility. This review explores the role of three blood‐based biomarkers; plasma amyloid β, tau and neurofilament light chain, and their combination, in the identification of AD pathology and how they may be utilised in clinical practice.
{"title":"Blood‐based biomarkers for Alzheimer's disease","authors":"Priyanka Chohan, Mark Dashwood, George Theodoulou, Hannah C. Reed, T. Kuruvilla","doi":"10.1002/pnp.764","DOIUrl":"https://doi.org/10.1002/pnp.764","url":null,"abstract":"Blood‐based biomarkers for identifying Alzheimer's disease (AD) pathology have been of considerable interest over the past decade and can offer a significant advantage over the currently available and validated cerebrospinal fluid and positron emission tomography biomarkers in terms of cost, invasiveness and accessibility. This review explores the role of three blood‐based biomarkers; plasma amyloid β, tau and neurofilament light chain, and their combination, in the identification of AD pathology and how they may be utilised in clinical practice.","PeriodicalId":43913,"journal":{"name":"Progress in Neurology and Psychiatry","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48153706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cluster headache is a potentially debilitating condition that can lead to restrictions in occupational and day‐to‐day function. Here, the authors outline a case of a significant reduction in headache frequency in a patient who had an incomplete response to NICE‐recommended treatments, and was treated for attention deficit hyperactivity disorder with stimulant medications. This article builds on a small number of case reports indicating a potential role for stimulant medications such as methylphenidate in the management of cluster headache.
{"title":"Methylphenidate as a potential treatment for cluster headache","authors":"Sophie McBrien, James Fallon","doi":"10.1002/pnp.765","DOIUrl":"https://doi.org/10.1002/pnp.765","url":null,"abstract":"Cluster headache is a potentially debilitating condition that can lead to restrictions in occupational and day‐to‐day function. Here, the authors outline a case of a significant reduction in headache frequency in a patient who had an incomplete response to NICE‐recommended treatments, and was treated for attention deficit hyperactivity disorder with stimulant medications. This article builds on a small number of case reports indicating a potential role for stimulant medications such as methylphenidate in the management of cluster headache.","PeriodicalId":43913,"journal":{"name":"Progress in Neurology and Psychiatry","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47075957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Caring responsibilities for children and family members with complex health care needs often go unnoticed among health care staff. Statistically, a significant portion of these responsibilities are met by women, widening the gender pay gap. This article highlights the impact of caring responsibilities on physicians and the need for more inclusive work and leave policies to support recruitment and retention of this workforce, valuing both professional and lived experience in care giving.
{"title":"Caring for carers within the psychiatry workforce","authors":"R. Maitra, Sue McCowan, Marta C Cohen","doi":"10.1002/pnp.763","DOIUrl":"https://doi.org/10.1002/pnp.763","url":null,"abstract":"Caring responsibilities for children and family members with complex health care needs often go unnoticed among health care staff. Statistically, a significant portion of these responsibilities are met by women, widening the gender pay gap. This article highlights the impact of caring responsibilities on physicians and the need for more inclusive work and leave policies to support recruitment and retention of this workforce, valuing both professional and lived experience in care giving.","PeriodicalId":43913,"journal":{"name":"Progress in Neurology and Psychiatry","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41642642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Z. Hepburn, Katherine Broomfield, Nicola Dowdeswell, Marelle Harvey, Jessica Lane, Mark Walker, T. Kuruvilla
Promoting research in NHS trusts is known to be beneficial for patient outcomes and clinicians’ attitudes towards research and recruitment to studies. Here the authors report their evaluation of a research champions initiative at a specialist mental health and community services trust.
{"title":"A qualitative evaluation of a research champions initiative in an NHS Trust","authors":"Z. Hepburn, Katherine Broomfield, Nicola Dowdeswell, Marelle Harvey, Jessica Lane, Mark Walker, T. Kuruvilla","doi":"10.1002/pnp.770","DOIUrl":"https://doi.org/10.1002/pnp.770","url":null,"abstract":"Promoting research in NHS trusts is known to be beneficial for patient outcomes and clinicians’ attitudes towards research and recruitment to studies. Here the authors report their evaluation of a research champions initiative at a specialist mental health and community services trust.","PeriodicalId":43913,"journal":{"name":"Progress in Neurology and Psychiatry","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42260222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Here, the authors discuss a patient with mild intellectual disability and Down's syndrome who appeared to experience deterioration in her well controlled thyroid function twice, secondary to higher dosages of risperidone for treatment of her delusional disorder. The case therefore suggests that thyroid function monitoring may be of value in individuals predisposed to thyroid dysfunction who are commenced on antipsychotic therapy, especially risperidone.
{"title":"Thyroid dysfunction in Down's syndrome secondary to risperidone","authors":"F. Shaddel, Matthew Lockstone","doi":"10.1002/pnp.766","DOIUrl":"https://doi.org/10.1002/pnp.766","url":null,"abstract":"Here, the authors discuss a patient with mild intellectual disability and Down's syndrome who appeared to experience deterioration in her well controlled thyroid function twice, secondary to higher dosages of risperidone for treatment of her delusional disorder. The case therefore suggests that thyroid function monitoring may be of value in individuals predisposed to thyroid dysfunction who are commenced on antipsychotic therapy, especially risperidone.","PeriodicalId":43913,"journal":{"name":"Progress in Neurology and Psychiatry","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47133829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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