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Tomato Flu - Should Pakistan be Worried? 番茄流感——巴基斯坦应该担心吗?
IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-02-25 DOI: 10.21649/akemu.v28i4.5263
Abdullah Haroon, Javaria Saleem
A new virus has emerged as an endemic in India and due to its highly contagious nature, is of great concern.1 The population of Kerala is 3.34crores, population growth of 4.91% current decade, contributing to about 2.76% of the total population of India. Making the spread of infections easier.2 Tomato flu is a viral infection that predominantly infects children under the age of 5 years. Tomato flu gets its name from red-coloured, tomatoshaped blisters that develop on different parts of the body, similar to those developed during monkeypox infection.1 Tomato flu presents symptoms like any other viral infection including COVID-19 infection, but it is not associated with SARS-CoV-2.3
印度出现了一种新的地方性病毒,由于其高度传染性,引起了人们的高度关注喀拉拉邦人口为334万,人口增长率为4.91%,占印度总人口的2.76%。使传染病更容易传播番茄流感是一种主要感染5岁以下儿童的病毒感染。番茄流感得名于身体不同部位出现的红色番茄形水泡,类似于猴痘感染期间出现的水泡番茄流感表现出与其他病毒感染(包括COVID-19感染)类似的症状,但与SARS-CoV-2.3无关
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引用次数: 0
Relationship Between Water, Sanitation, Climate Change, and COVID-19 水、卫生设施、气候变化与COVID-19之间的关系
IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-02-25 DOI: 10.21649/akemu.v28i4.5313
Nabiha Khalid
Climate change is the utmost crucial challenge of the 21st century with the significant potential to cause human and economic damage. COVID-19 is a global public health emergency that has caused millions of deaths worldwide.1 Studies reported that thorough sanitation practices, safe and clean water, and proper hygiene services are considered the crucial part of protecting the health of humans during the infectious disease outbreaks such as the global COVID-19 outbreak.2
气候变化是21世纪最严峻的挑战,有可能对人类和经济造成重大损害。COVID-19是一场全球突发公共卫生事件,已在全球造成数百万人死亡研究报告称,彻底的卫生习惯、安全和清洁的水以及适当的卫生服务被认为是在2019冠状病毒病等传染病暴发期间保护人类健康的关键部分
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引用次数: 0
Steroids use in Severe/ Life Threatening COVID-19 Pneumonia: Does the Type or Dose Matter? 在严重/危及生命的COVID-19肺炎中使用类固醇:类型或剂量重要吗?
IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-02-25 DOI: 10.21649/akemu.v28i4.5310
A. Arshad, B. Saeed, S. Hussain
Objective: To compare the effect of different doses of methylprednisolone and dexamethasone on in-hospital mortality in severe COVID-19 pneumonia Methods: This retrospective chart review was done by reviewing old medical reports of patients with severe disease admitted to COVID-19 Intensive Care and High Dependency Unit from October 2020 to September 2021. Those with suspected COVID-19 infection (suggestive radiological findings but negative PCR for SARSCoV- 2 on at least two occasions) were excluded. Patients requiring high flow oxygen (>6 liters per minute) or higher levels of respiratory support were classified as having severe disease. We recorded the type of steroids used and the doses. Methylprednisolone in doses up to 40mg per day, or other steroids in equivalent doses, were considered low dose. Primary outcome of interest was in- hospital mortality. Results: There were 279 patients aged 52.53± 11.31 years, including 216 (77.42%) males. Mean hospital stay was 10.18± 3.13 days. During hospital stay, 96 (34.41%) patients died. Amongst patients receiving dexamethasone, 70 (44.87%) expired, whereas 26 (21.14%) out of 123 patients who received methylprednisolone expired (p
目的:比较不同剂量甲基强的松龙和地塞米松对COVID-19重症肺炎住院死亡率的影响方法:通过回顾2020年10月至2021年9月COVID-19重症监护高依赖病房收治的重症患者的旧医疗报告,进行回顾性图表复习。排除疑似COVID-19感染的患者(影像学提示,但PCR至少两次SARSCoV- 2阴性)。需要高流量氧气(>6升/分钟)或更高水平呼吸支持的患者被归类为重症患者。我们记录了使用类固醇的种类和剂量。甲基强的松龙的剂量为每天40毫克,或其他类固醇的剂量为同等剂量,被认为是低剂量。主要研究终点为住院死亡率。结果279例患者,年龄52.53±11.31岁,其中男性216例(77.42%)。平均住院时间10.18±3.13 d。住院期间死亡96例(34.41%)。在接受地塞米松治疗的患者中,70例(44.87%)患者死亡,而123例接受甲基强的松龙治疗的患者中,26例(21.14%)患者死亡(p
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引用次数: 0
Satisfaction and Self-Confidence of Undergraduate Nursing Students with Simulation-Based Learning Experiences 护理本科生模拟学习体验的满意度与自信心
IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-02-25 DOI: 10.21649/akemu.v28i4.5261
Mamoona Iram, N. Rizvi, Nazia Ilyas, Eunice Siaty, A. Nazar, Zohra Kurji
Background: Hands-on patient care could be best experienced through clinical rotations; however, opportunities for direct patient care for student nurses are limited due to lack of clinical sites and availability of patients, faculty shortages, and some ethical and safety concerns. The purpose to measure the satisfaction and self-confidence of nursing students with their simulation-based learning. Methodology: This study used an analytic cross-sectional design. The study was conducted at a private university in Karachi, Pakistan, and recruited 230 nursing students using a total population sampling technique. A self-reporting questionnaire was used to collect data. ANOVA was used to see the differences in the mean scores, and Pearson correlation was used to assess the correlation between satisfaction and self confidence. Results: The overall mean + SD of satisfaction was 75.80 + 8.93 and for self-confidence was 32.59 + 3.61. Findings revealed a significant difference in mean scores of satisfaction and self-confidence among the study groups, p < 0.05. A strong positive correlation, Pearson r = 0.725, p = 0.001, was revealed between the satisfaction and self-confidence. Conclusion: The study discovered that simulation-based learning plays a significant role in increasing satisfaction and in building the self-confidence of nursing students, so it should be made a part of their curriculum, and integrated into all possible courses in the undergraduate nursing programs.
背景:实践病人护理可以通过临床轮转最好的体验;然而,由于缺乏临床场地和病人的可用性,师资短缺,以及一些道德和安全问题,学生护士直接护理病人的机会有限。目的了解护生对模拟学习的满意度和自信心。研究方法:本研究采用分析横断面设计。该研究在巴基斯坦卡拉奇的一所私立大学进行,采用总体抽样技术招募了230名护理专业学生。采用自我报告问卷收集数据。采用方差分析(ANOVA)观察平均得分的差异,采用Pearson相关分析评估满意度与自信心的相关性。结果:满意度总体均值+ SD为75.80 + 8.93,自信心总体均值+ SD为32.59 + 3.61。结果显示,各研究组满意度和自信心平均得分差异有统计学意义,p < 0.05。满意度与自信心呈显著正相关,Pearson r = 0.725, p = 0.001。结论:本研究发现模拟学习对提高护理学生的满意度和自信心有显著作用,应将其作为护理专业课程的一部分,并融入到护理专业的所有可能课程中。
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引用次数: 0
Maternal Hypothyroidism Influences the Weight of Brain and Impairs the Migration of Neurons Inside the Hippocampus of Neonatal Rat 母体甲状腺功能减退影响新生大鼠脑重量及海马内神经元迁移
IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-02-25 DOI: 10.21649/akemu.v28i4.5259
Mariyah Hidayat, Khayyam Arif Rana, Nabila Kaukab
Objective: To histologically observe the effects of hypothyroidism on the hippocampus of neonatal rats. Methods: A total of 10 healthy female Wistar rats, between 12-16 weeks old, were randomly divided into 2 groups; Group A was labelled as control and Group B was made hypothyroid by giving 15mg/kg of Propylthiouracyl (PTU) daily mixed in chow. The treatment was continued for a week before they were allowed to mate and conceive, and it was not interrupted throughout pregnancy and delivery until 21st day of lactation. On the 22nd day, 10 pups from each of the two groups were euthanized; 3cc of blood was drawn out from the heart immediately and the brains were scooped out, weighed, fixed in formalin after slicing out the cerebrum along with hippocampus, processed and stained to observe the arrangement and count and number of pyramidal neurons of CA3 region of hippocampus. Results: There was a significant decrease in the brain weights of group B pups (1.21 ± 0.21mg) when compared to the control group A (1.42 ± 0.01mg). The thyroxine (T4) level from the experimental group B was significantly decreased (27.7 ±1.2 ng/dl) compared to control (32.1 ± 0.9 ng/dl). Moreover, the serum levels of TSH were significantly higher in group B (21 ± 3.7ng/dl) as compared to group A (15 ± 2.4 ng/dl). The number of pyramidal cell count in group B was significantly decreased (39 ± 1.24 per unit area) as compared to group A (44 ± 2.49 per unit area). Conclusion: Maternal hypothyroidism not only exerts its' influence on the arrangement of Pyramidal neurons of CA3 area of hippocampus, but it also decreases their count. Overall, it effects the weight of the brain and significantly raises the levels of TSH in the neonates.
目的:组织学观察甲状腺功能减退症对新生大鼠海马的影响。方法:选取12 ~ 16周龄的健康雌性Wistar大鼠10只,随机分为2组;A组为对照组,B组每日在饲料中添加15mg/kg丙基硫脲基(PTU),使甲减。在允许它们交配和怀孕之前,治疗持续了一周,并且在整个怀孕和分娩过程中直到哺乳期第21天都没有中断。第22天,两组各10只幼犬实施安乐死;立即从心脏抽血3cc,将大脑与海马一起切开后,舀出大脑,称重,用福尔马林固定,处理染色,观察海马CA3区锥体神经元的排列、计数和数量。结果:B组幼崽脑重(1.21±0.21mg)显著低于对照组(1.42±0.01mg)。实验B组甲状腺素(T4)水平较对照组(32.1±0.9 ng/dl)显著降低(27.7±1.2 ng/dl)。此外,B组血清TSH水平(21±3.7ng/dl)明显高于A组(15±2.4 ng/dl)。与A组(44±2.49个/单位面积)相比,B组锥体细胞计数明显减少(39±1.24个/单位面积)。结论:产妇甲状腺功能减退不仅影响海马CA3区锥体神经元的排列,而且使其数量减少。总的来说,它会影响大脑的重量,并显著提高新生儿体内促甲状腺激素的水平。
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引用次数: 0
Incidence of COVID-19 Infection in Nurses and their Families: A Prospective Cohort Study in Lahore 拉合尔护士及其家属COVID-19感染发生率:一项前瞻性队列研究
IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-02-25 DOI: 10.21649/akemu.v28i4.5258
I. Manzoor, A. Hameed, M. Khan, Allah Yar Khan, Amna Ayub
Background: Nurses, as frontline workers, are at a higher risk of contracting COVID19 and serve as a potential source of transmitting this infection to their family members. Estimating risk in this population is critical for controlling the rate of secondary attack rate among their families. Objective: To measure the incidence of COVID-19 in nurses and their families with associated risk factors for transmission of infection. Methods: A prospective cohort study was conducted in Akhtar Saeed Medical and Dental college, Lahore and associated three hospitals. A cohort of 176 nurses was identified in March 2020 by using non-probability convenience sampling technique and was followed till September 2021. During this tenure of one and a half year, incidence was observed by following the cohort and using a self-structured questionnaire. With SPSS 23, Chi square test was applied and p value of < 0.05 was considered significant. Results: In a cohort of 176 nurses, followed for one and a half year, incidence of COVID-19 was 37(21%). Secondary attack rate among household members of these nurses was 3%. A significant association was observed between the nursing staff and exposure to their family members (p = 0.002). Vaccination rate in nurses at the start of the study was only 26%. Nurses who worked directly with COVID-19 patients reported high incidence (p = 0.009). Nurses who used Personal protective equipment (PPE) were less affected (p = 0.003). Nurses with comorbidities showed higher incidence (p =0.02). Rate of psychological distress was high (p =0.007). Conclusion: Incidence of COVID-19 among nurses was 21% with secondary attack rate of 3% in families. Protective use of N 95 mask and comorbidities were associated with incidence.
背景:护士作为一线工作人员,感染covid - 19的风险较高,是将这种感染传播给其家庭成员的潜在来源。估计这一人群的风险对于控制其家庭的继发发病率至关重要。目的:了解2019冠状病毒病(COVID-19)在具有相关感染传播危险因素的护士及其家属中的发病率。方法:在拉合尔Akhtar Saeed医学和牙科学院及相关三家医院进行前瞻性队列研究。采用非概率方便抽样技术,于2020年3月确定176名护士,随访至2021年9月。在这一年半的任期内,通过跟踪队列并使用自结构问卷来观察发病率。采用SPSS 23进行卡方检验,p值< 0.05被认为是显著的。结果:随访1年半的176名护士中,COVID-19发病率为37例(21%)。护理人员家属的二次发作率为3%。护理人员与其家庭成员接触之间存在显著相关性(p = 0.002)。研究开始时,护士的疫苗接种率仅为26%。直接接触COVID-19患者的护士发病率较高(p = 0.009)。使用个人防护装备的护士受影响较小(p = 0.003)。有合并症的护士发生率较高(p =0.02)。心理困扰发生率高(p =0.007)。结论:护士感染新冠肺炎的发生率为21%,家庭继发率为3%。n95口罩的防护使用和合并症与发病率相关。
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引用次数: 0
Effectiveness of Post Isometric Relaxation Versus Reciprocal Inhibition Technique on Hamstring Muscle Flexibility 等长后放松与相互抑制技术对腘绳肌柔韧性的影响
IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-08-04 DOI: 10.21649/akemu.v28i2.5112
Asma Aleem, Muhammad Arfan, A. Razzaq, Rooh ul Husnain Khizar, Mehboob Ali
Background: To expand the muscular extensibility, alternation of muscle energy techniques have been upheld, yet proof present to help the general value of a specific methodology. Two strategies of muscle energy techniques have been explored in the osteopathic writing that differs principally in the group of muscles focused on. Objective: The objective of our study was to find out the effectiveness of post isometric relaxation and reciprocal inhabitation technique on hamstring muscle flexibility among students of Johar Institute of Professional Studies Lahore. Methods: The Quasi-experimental study was for comparison of two Relaxation Techniques with 50 healthy students of both gender were recruited by non-probability convenient sampling technique from different department of Johar Institute st of Professional Studies Lahore from 1 October to March 2020. For enrolling the subjects in this study we used convenience sampling technique. Furthermore, 50 subjects were selected on the basis of inclusion exclusion criteria and were arbitrarily divided in to two groups with 25 in each group. Hamstring length was assessed using AKE test. For intervention, Group A performed post isometrics relaxation and Group B performed Reciprocal Inhibition Technique. Knee range of motion was assessed pre-intervention and post-intervention. Numeric Pain Rating Scale (NPRS) and Universal Goniometer were assessment tools accessed for all patients before and after 4 weeks of physical therapy intervention. Data were documented and analysis was done using SPSS version 20. Paired sample t-test and independent sample t-test was applied to find association between the variables of hypothesis. Results: In both groups, the pre-intervention and post-intervention measurements by statistical analysis found that there is significant improvement in hamstring muscle flexibility with P value ≤ 0.05 for both right side and left side. Conclusion: The current study found out that both post isometric relaxation and reciprocal inhibition are equally beneficial in the treatment of tight hamstrings.
背景:为了扩大肌肉的可伸伸性,肌肉能量技术的交替一直被支持,但目前的证据有助于特定方法的一般价值。肌肉能量技术的两种策略已经在骨科写作中进行了探索,主要不同于所关注的肌肉群。目的:研究拉合尔Johar职业学院学生进行等长后放松和互惠居住技术对腘绳肌柔韧性的影响。方法:采用非概率方便抽样方法,于2020年10月1日至2020年3月从拉合尔Johar职业学院不同院系招收50名男女健康学生,进行两种放松技术的准实验研究。本研究采用方便抽样方法招募研究对象。根据纳入排除标准选择50例受试者,随机分为两组,每组25例。采用AKE试验评估腘绳肌长度。干预时,A组采用后等距松弛法,B组采用互抑法。评估干预前和干预后的膝关节活动度。数值疼痛评定量表(NPRS)和通用角计是所有患者在物理治疗干预前和4周后使用的评估工具。数据记录和分析使用SPSS版本20完成。采用配对样本t检验和独立样本t检验来发现假设变量之间的相关性。结果:通过统计分析,两组患者干预前和干预后腘绳肌柔韧性均有显著改善,且左右侧均P值≤0.05。结论:本研究发现,等距后放松和相互抑制对腘绳肌紧绷的治疗同样有益。
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引用次数: 1
Volume Assessment in Paediatric Hemodialysis Using Lung Ultra Sonography 利用肺超音波评估儿科血液透析的容积
IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-08-04 DOI: 10.21649/akemu.v28i2.5091
Ch Muhammad Umer Razaq, I. Ijaz, Khoola Bint-e-Mansoor, K. Mehmood, A. Tariq, Farnaz Abbas
Background: It is a significant challenge clinically to optimize the weight of children and infants. It is our hypothesis that in children receiving dialysis fluid overload can be quantified using lung ultrasound. Objectives: 1. To determine the frequency of diagnosing pulmonary edema using lung ultrasound and clinical examination. 2. To determine association of percentage decrease in weight with number of B-lines in children with renal failure undergoing hemodialysis Methods: This cross sectional study was conducted in Division of Pediatric Nephrology, Paediatric unit II, Mayo Hospital Lahore from June 2020 till December 2020 after approval of hospital committee. Patients aged 6 to 16 years undergoing regular hemodialysis after chronic kidney disease were enrolled. Lung ultrasound examinations were performed before start of dialysis and after completion of dialysis. B lines were measured on the ultrasound along with comparing the proportional increase in weight from the target weight. Results: Eighty one lung ultrasound assessments were performed in total. Mean age was 10.4±3.3 years. There were 56(69.1%) males and 25 (30.8%) female patients. Mean percentage decrease in weight was 5.5±2.4% before dialysis and 0.96±0.6% after dialysis, p-value
背景:优化婴幼儿体重是临床面临的重大挑战。这是我们的假设,在接受透析的儿童液体超载可以量化使用肺超声。目的:1。目的探讨肺部超声及临床检查对肺水肿的诊断频率。2. 为了确定接受血液透析的肾功能衰竭儿童体重下降百分比与b线数量的关系方法:经医院委员会批准,该横断面研究于2020年6月至2020年12月在拉合尔梅奥医院儿科II科儿科肾脏病科进行。年龄6 - 16岁的慢性肾病患者接受定期血液透析。透析开始前和透析结束后分别行肺超声检查。在超声波上测量B线,并比较体重与目标体重的比例增加。结果:共进行肺超声检查81次。平均年龄10.4±3.3岁。男性56例(69.1%),女性25例(30.8%)。透析前体重平均下降5.5%±2.4%,透析后体重平均下降0.96±0.6%,p值
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引用次数: 0
Hepatitis C Drugs Made in Pakistan 巴基斯坦制造的丙型肝炎药物
IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-08-04 DOI: 10.21649/akemu.v28i2.5118
Nida Waheed, Tooba Fida, Saman Fatima, Osman Khalid Waheed
Hepatitis C is among the most prevalent liver diseases in the world caused by hepatitis C virus and it further predisposes the patient to liver cancers. This virus is transmitted through the use of infected syringes, infected blood transfusions and sexual contact with affected individuals. This disease is asymptomatic initially but may follow an acute or chronic progressive course. Pakistan has a significant ratio of hepatitis affected patients with every one out of 20 individuals being seropositive. The treatment of hepatitis and its success is dependent upon the early diagnosis of the disease through the identification of anti HCV antibodies and further disease confirmation by detection of HCV RNA through nucleic acid amplification tests. Ferozsons pharmaceutical company is credited with the introduction of effective Hepatitis C treatments in Pakistan which were initially were expensive. However, with the development of new and better medicines the cost reduced effectively and the treatment is now affordable by people with low income. Many actions have been taken at the government level which have made mass screening of the individuals along with appropriate and timely supply of medications possible. Another important step in eradicating Hepatitis C is the education of the public by advertisements, seminars and HCV courses conducted by specialists. Project ECHO deserves mention, as it shows that people treated according to ECHO methodology have better prognosis than the others.
丙型肝炎是由丙型肝炎病毒引起的世界上最普遍的肝脏疾病之一,它进一步使患者易患肝癌。这种病毒通过使用受感染的注射器、受感染的输血和与受感染个体的性接触传播。本病最初无症状,但可呈急性或慢性进行性病程。巴基斯坦的肝炎患者比例很高,每20个人中就有一人血清呈阳性。肝炎的治疗及其成功取决于通过鉴定抗HCV抗体对疾病进行早期诊断,并通过核酸扩增试验检测HCV RNA进一步确认疾病。Ferozsons制药公司因在巴基斯坦引进有效的丙型肝炎治疗而受到赞誉,这些治疗最初是昂贵的。然而,随着新的和更好的药物的发展,成本有效地降低了,现在低收入的人也能负担得起这种治疗。政府采取了许多行动,对个人进行了大规模筛查,并提供了适当和及时的药物。根除丙型肝炎的另一个重要步骤是通过广告、研讨会和专家举办的丙型肝炎病毒课程对公众进行教育。值得一提的是ECHO项目,因为它表明采用ECHO方法治疗的患者预后比其他方法更好。
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引用次数: 0
Problems in Physician-Patient Communication: What do our Students See and Hear? A Qualitative Study with a Pragmatic Approach 医患沟通中的问题:我们的学生看到和听到了什么?用语用方法进行质的研究
IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-08-04 DOI: 10.21649/akemu.v28i2.5097
Ayesha Younas, R. Khan, Rahila Yasmeen, U. Mahboob, A. Ansar
Background: Efficient communication with patients is an indispensable necessity for physicians of the 21 century. Over the past decades, much work has been done nationally and internationally to instill this essential skill in undergraduate students and medical graduates are now formally trained to become better communicators. However, deficiencies persist and medical students of today still observe various issues when they observe physician- patient communication interactions in their training. Objective: To understand perceptions of undergraduate medical students about the difficulties in Physician-Patient communication (PPC) & take suggestions on how to overcome them. Methods: A qualitative study design was employed, with data collection through three focus group discussions with medical students studying in Wah medical college, Pakistan in October 2019. Thematic data analysis was done using Atlas-ti 8 software. A pragmatic approach was used to understand student perceptions about difficulties in PPC. Conclusion: The various issues regarding the problems in physician patient communication portray a realistic picture of our current communication practices. Various factors have been identified in this study and, the most practical solution to these problems lies in the effective teaching of behavioral sciences.
背景:对21世纪的医生来说,与患者进行有效的沟通是必不可少的。在过去的几十年里,国内外已经做了很多工作,向本科生灌输这一基本技能,现在医学毕业生正在接受正式培训,成为更好的沟通者。然而,缺陷仍然存在,今天的医学生在他们的培训中观察医患沟通互动时仍然观察到各种问题。目的:了解医学生对医患沟通困难的看法,并提出解决医患沟通困难的建议。方法:采用定性研究设计,于2019年10月对巴基斯坦华医学院的医学生进行三次焦点小组讨论,收集数据。采用Atlas-ti - 8软件进行专题数据分析。采用务实的方法来了解学生对PPC困难的看法。结论:关于医患沟通问题的各种问题描绘了我们当前沟通实践的现实图景。在本研究中发现了各种各样的因素,而解决这些问题的最实际的办法在于有效的行为科学教学。
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引用次数: 0
期刊
Annals of King Edward Medical University Lahore Pakistan
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