Pub Date : 2025-01-04DOI: 10.1016/j.trac.2025.118133
Zhong Wei Jiang , Xue Gong , Pu Zhang , Yi Wang
Lanthanide metal-organic frameworks (Ln-MOFs), composed of organic ligands and Ln3+ ions/clusters, are a prominent member of luminescent MOFs with diverse geometries and abundant luminescent properties, offering chances to explore EnT mechanisms and develop ratiometric fluorescent sensors. The EnT-involved Ln-MOFs can provide a forward-looking design concept for directional EnT processes and more sensitive and accurate sensing performance. Despite extensive research on the characteristics of Ln-MOFs with tunable fluorescence emission, designing high-sensitivity and selectivity ratiometric sensors is quite difficult without in-depth insight into these potential EnT mechanisms. In this progress report, the typical EnT mechanisms behind Ln-MOFs are outlined, and highlighted the tunable EnT processes in Ln-MOFs for enhancing luminescence and sensing. Additionally, the forthcoming challenges and directions for future progress are outlined, aiming to guide the design of Ln-MOFs with excellent sensing performance through rational EnT engineering.
{"title":"Energy transfer engineering in lanthanide metal-organic frameworks for ratiometric fluorescence sensing","authors":"Zhong Wei Jiang , Xue Gong , Pu Zhang , Yi Wang","doi":"10.1016/j.trac.2025.118133","DOIUrl":"10.1016/j.trac.2025.118133","url":null,"abstract":"<div><div>Lanthanide metal-organic frameworks (Ln-MOFs), composed of organic ligands and Ln<sup>3+</sup> ions/clusters, are a prominent member of luminescent MOFs with diverse geometries and abundant luminescent properties, offering chances to explore EnT mechanisms and develop ratiometric fluorescent sensors. The EnT-involved Ln-MOFs can provide a forward-looking design concept for directional EnT processes and more sensitive and accurate sensing performance. Despite extensive research on the characteristics of Ln-MOFs with tunable fluorescence emission, designing high-sensitivity and selectivity ratiometric sensors is quite difficult without in-depth insight into these potential EnT mechanisms. In this progress report, the typical EnT mechanisms behind Ln-MOFs are outlined, and highlighted the tunable EnT processes in Ln-MOFs for enhancing luminescence and sensing. Additionally, the forthcoming challenges and directions for future progress are outlined, aiming to guide the design of Ln-MOFs with excellent sensing performance through rational EnT engineering.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"184 ","pages":"Article 118133"},"PeriodicalIF":11.8,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143157603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Environmental pollution is a critical global issue which adversely impacts human health, ecosystems and biodiversity. It results from a number of sources, including industrial activities, agricultural practices, and urbanization that lead to the significant contamination of air, water, and soil. These pollutants can cause severe health problems, disrupt natural processes, and contribute to climate change. Ion imprinting technique holds significant promise for the application in environmental cleanup and the treatment of industrial effluents, particularly in dealing with environmental samples which contains trace levels of harmful and persistent heavy metals. This review paper highlights the latest developments in ion imprinting technology related to sensitive and selective binding as well as effective separation, emphasizing the environmentaly-friendly approaches for producing ion imprinted polymers and their use in removing metal ions from environmental samples.
{"title":"Environmentally-friendly ion imprinted polymers (IIPs) towards metal pollutants in environmental samples: Recent advances and future prospects","authors":"Rüstem Keçili , Chaudhery Ghazanfar Hussain , Fatemeh Ghorbani-Bidkorpeh , Chaudhery Mustansar Hussain","doi":"10.1016/j.trac.2024.118132","DOIUrl":"10.1016/j.trac.2024.118132","url":null,"abstract":"<div><div>Environmental pollution is a critical global issue which adversely impacts human health, ecosystems and biodiversity. It results from a number of sources, including industrial activities, agricultural practices, and urbanization that lead to the significant contamination of air, water, and soil. These pollutants can cause severe health problems, disrupt natural processes, and contribute to climate change. Ion imprinting technique holds significant promise for the application in environmental cleanup and the treatment of industrial effluents, particularly in dealing with environmental samples which contains trace levels of harmful and persistent heavy metals. This review paper highlights the latest developments in ion imprinting technology related to sensitive and selective binding as well as effective separation, emphasizing the environmentaly-friendly approaches for producing ion imprinted polymers and their use in removing metal ions from environmental samples.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"184 ","pages":"Article 118132"},"PeriodicalIF":11.8,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143157596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.trac.2024.118130
Xianfeng Lin , Lixin Kang , Jiaqi Feng , Nuo Duan , Zhouping Wang , Shijia Wu
As a class of emerging programmable endonucleases, prokaryotic Argonaute (pAgo) has attracted much attention in biotechnology. In recent years, benefiting from their stability and design flexibility of guide DNA, excellent nucleic acid cleavage capabilities, high specificity, and multiple-turnover activity, pAgo has also been applied to biosensing, providing new insights into analytical chemistry. Herein, the structure and working mechanism of common pAgos were first introduced. Then, pAgo-based sensing strategies for different targets were categorized and discussed comprehensively, emphasizing their design principles. For nucleic acid detection, in addition to commonly used cleavage activity, some assays utilize the binding activity of catalytically inactive pAgo. With the introduction of biorecognition molecules and mesophilic pAgo, pAgo was tapped to detect non-nucleic acid targets, greatly broadening their application scope. Finally, the current challenges and prospects of this field were critically discussed. This review is anticipated to provide references and ideas for developing novel pAgo-based sensing platforms.
{"title":"Versatile sensing strategies based on emerging programmable prokaryotic Argonautes: From nucleic acid to non-nucleic acid targets","authors":"Xianfeng Lin , Lixin Kang , Jiaqi Feng , Nuo Duan , Zhouping Wang , Shijia Wu","doi":"10.1016/j.trac.2024.118130","DOIUrl":"10.1016/j.trac.2024.118130","url":null,"abstract":"<div><div>As a class of emerging programmable endonucleases, prokaryotic Argonaute (pAgo) has attracted much attention in biotechnology. In recent years, benefiting from their stability and design flexibility of guide DNA, excellent nucleic acid cleavage capabilities, high specificity, and multiple-turnover activity, pAgo has also been applied to biosensing, providing new insights into analytical chemistry. Herein, the structure and working mechanism of common pAgos were first introduced. Then, pAgo-based sensing strategies for different targets were categorized and discussed comprehensively, emphasizing their design principles. For nucleic acid detection, in addition to commonly used cleavage activity, some assays utilize the binding activity of catalytically inactive pAgo. With the introduction of biorecognition molecules and mesophilic pAgo, pAgo was tapped to detect non-nucleic acid targets, greatly broadening their application scope. Finally, the current challenges and prospects of this field were critically discussed. This review is anticipated to provide references and ideas for developing novel pAgo-based sensing platforms.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"184 ","pages":"Article 118130"},"PeriodicalIF":11.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143157670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-31DOI: 10.1016/j.trac.2024.118131
Xueting Lu , Jinpei Du , Minli You , Liben Chen , Feng Xu , Fenghao Chen
Global pandemics, like COVID-19, pose severe threats to human health and disrupt social and economic systems. Rapid, accurate, and accessible in vitro diagnostic (IVD) methods, particularly point-of-care testing (POCT), were essential for managing the crisis. The emergency authorization of numerous POCT devices accelerated the development of novel detection technologies. While thousands of emergency-approved COVID-19 tests helped mitigate the pandemic, humanity remains vulnerable to future epidemics. In this review, we analyze the relationship between the approval detection tests and the pandemic progress during the five phases of the COVID-19 pandemic and provide insights of ideal IVD technologies into different phases. We also examine the working principles, advantages, and disadvantages of several representative COVID-19 tests and introduce emerging POCT technologies to address the current challenges. Finally, we discuss the future development and deployment of POCT technologies for managing future global pandemics.
{"title":"From crisis to innovation in point-of-care testing: Lessons from the COVID-19 pandemic and future directions","authors":"Xueting Lu , Jinpei Du , Minli You , Liben Chen , Feng Xu , Fenghao Chen","doi":"10.1016/j.trac.2024.118131","DOIUrl":"10.1016/j.trac.2024.118131","url":null,"abstract":"<div><div>Global pandemics, like COVID-19, pose severe threats to human health and disrupt social and economic systems. Rapid, accurate, and accessible <em>in vitro</em> diagnostic (IVD) methods, particularly point-of-care testing (POCT), were essential for managing the crisis. The emergency authorization of numerous POCT devices accelerated the development of novel detection technologies. While thousands of emergency-approved COVID-19 tests helped mitigate the pandemic, humanity remains vulnerable to future epidemics. In this review, we analyze the relationship between the approval detection tests and the pandemic progress during the five phases of the COVID-19 pandemic and provide insights of ideal IVD technologies into different phases. We also examine the working principles, advantages, and disadvantages of several representative COVID-19 tests and introduce emerging POCT technologies to address the current challenges. Finally, we discuss the future development and deployment of POCT technologies for managing future global pandemics.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"184 ","pages":"Article 118131"},"PeriodicalIF":11.8,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143157666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-30DOI: 10.1016/j.trac.2024.118128
Yiting Wang , Yuwei Pan , Wenchao Han , Carla Spatola Rossi , Qingxin Hui , Ying Guo , Mojisola Christiana Owoseni , Ewan McAdam , Yang-Chun Yong , Baojun Wang , Zhugen Yang
There is increasing attention on the impacts of contaminants on environmental and human health. To better understand the potential threat to ecosystems and human health, biosensing has played an important role in monitoring contaminants and biomarkers. In the past decade, the integration of CRISPR-Cas systems with technologies like microfluidic devices and isothermal amplification methods has paved the way for developing advanced sensors for environmental surveillance. Here we discuss the recent progress of various CRISPR-Cas systems to develop new biosensing devices, ranging from the fundamental mechanisms to their practical applications. We present a comprehensive and critical overview on the current state-of-the-art of CRISPR-Cas-based sensing platforms, including for both nucleic acid and non-nucleic acid contaminants, as well as portable engineered systems for on-site detection. We also provide the prospects of CRISPR-Cas systems for next-generation environmental surveillance, together with emerging technologies such as data science and artificial intelligence.
{"title":"CRISPR-enabled sensors for rapid monitoring of environmental contaminants","authors":"Yiting Wang , Yuwei Pan , Wenchao Han , Carla Spatola Rossi , Qingxin Hui , Ying Guo , Mojisola Christiana Owoseni , Ewan McAdam , Yang-Chun Yong , Baojun Wang , Zhugen Yang","doi":"10.1016/j.trac.2024.118128","DOIUrl":"10.1016/j.trac.2024.118128","url":null,"abstract":"<div><div>There is increasing attention on the impacts of contaminants on environmental and human health. To better understand the potential threat to ecosystems and human health, biosensing has played an important role in monitoring contaminants and biomarkers. In the past decade, the integration of CRISPR-Cas systems with technologies like microfluidic devices and isothermal amplification methods has paved the way for developing advanced sensors for environmental surveillance. Here we discuss the recent progress of various CRISPR-Cas systems to develop new biosensing devices, ranging from the fundamental mechanisms to their practical applications. We present a comprehensive and critical overview on the current state-of-the-art of CRISPR-Cas-based sensing platforms, including for both nucleic acid and non-nucleic acid contaminants, as well as portable engineered systems for on-site detection. We also provide the prospects of CRISPR-Cas systems for next-generation environmental surveillance, together with emerging technologies such as data science and artificial intelligence.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"184 ","pages":"Article 118128"},"PeriodicalIF":11.8,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143157671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-28DOI: 10.1016/j.trac.2024.118125
Fen Li , Weichang Gao , Yechun Lin , Jianling Liu , Yulong Su , Yuping Zhang , Kai Cai
Soil is a huge reservoir and source of volatile organic compounds (VOCs), which act as significant signaling molecules essential for interactions in the subsurface ecological network. Herein, we first introduce soil VOCs' source-sink, chemical classifications. From the microbial perspective, underground microbial VOCs act on microbe-microbe and microbe-plant interactions; From the plant perspective, underground plant root VOCs act on plant-microbe and plant-plant interactions, and the ecological functions and mechanisms behind these interactions were emphasized. Besides the concentration ranges of VOCs in ecological function cases were summarized. Then, the current methodology for extracting and enriching soil VOCs is described, both in-situ and ex-situ with static-based and dynamic-based gas adsorption extraction. It also lists instrumental analytical techniques, the classification of databases, and application prospects. These results will further help us deepen our understanding of volatomics and expand their potential applications in the future.
{"title":"Soil volatile organic compounds: Source-sink, function, mechanism, detection, and application analysis in environmental ecology","authors":"Fen Li , Weichang Gao , Yechun Lin , Jianling Liu , Yulong Su , Yuping Zhang , Kai Cai","doi":"10.1016/j.trac.2024.118125","DOIUrl":"10.1016/j.trac.2024.118125","url":null,"abstract":"<div><div>Soil is a huge reservoir and source of volatile organic compounds (VOCs), which act as significant signaling molecules essential for interactions in the subsurface ecological network. Herein, we first introduce soil VOCs' source-sink, chemical classifications. From the microbial perspective, underground microbial VOCs act on microbe-microbe and microbe-plant interactions; From the plant perspective, underground plant root VOCs act on plant-microbe and plant-plant interactions, and the ecological functions and mechanisms behind these interactions were emphasized. Besides the concentration ranges of VOCs in ecological function cases were summarized. Then, the current methodology for extracting and enriching soil VOCs is described, both <em>in</em>-<em>situ</em> and <em>ex</em>-<em>situ</em> with static-based and dynamic-based gas adsorption extraction. It also lists instrumental analytical techniques, the classification of databases, and application prospects. These results will further help us deepen our understanding of volatomics and expand their potential applications in the future.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"184 ","pages":"Article 118125"},"PeriodicalIF":11.8,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143157602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-28DOI: 10.1016/j.trac.2024.118126
Qamar Salamat , João Pedro Cezário Brandão , Anibal de Freitas Santos Junior , Mustafa Soylak
Deep eutectic solvent-based ferrofluids (DES-based FFs) are a novel type of magnetic material that shows great potential as extraction solvents in analytical chemistry. They are particularly useful for extracting, separating, and analyzing trace analytes from complex matrices. This is due to their distinctive properties, including magnetic separation, tunability, high efficiency, environmental friendliness, stability, enhanced mass transfer, reusability, and compatibility with various analytical methods. As a result, they are a highly attractive option for modern extraction processes. The current review paper briefly discusses the principles of DES and magnetic DES. Subsequently, this study examines and discusses various sub-categories of DES-based FFs, including different magnetic materials and types of DES. This is followed by an evaluation of the physical and chemical features of DES-based FFs. Furthermore, the utilization of this novel extraction solvent in sample preparation processes is evaluated. Lastly, this review paper examines the difficulties and potential future developments associated with utilizing DES-based FFs as extraction solvents.
{"title":"Deep eutectic solvent-based ferrofluids: Synthesis strategies, characteristics, and applications for trace analytes extraction","authors":"Qamar Salamat , João Pedro Cezário Brandão , Anibal de Freitas Santos Junior , Mustafa Soylak","doi":"10.1016/j.trac.2024.118126","DOIUrl":"10.1016/j.trac.2024.118126","url":null,"abstract":"<div><div>Deep eutectic solvent-based ferrofluids (DES-based FFs) are a novel type of magnetic material that shows great potential as extraction solvents in analytical chemistry. They are particularly useful for extracting, separating, and analyzing trace analytes from complex matrices. This is due to their distinctive properties, including magnetic separation, tunability, high efficiency, environmental friendliness, stability, enhanced mass transfer, reusability, and compatibility with various analytical methods. As a result, they are a highly attractive option for modern extraction processes. The current review paper briefly discusses the principles of DES and magnetic DES. Subsequently, this study examines and discusses various sub-categories of DES-based FFs, including different magnetic materials and types of DES. This is followed by an evaluation of the physical and chemical features of DES-based FFs. Furthermore, the utilization of this novel extraction solvent in sample preparation processes is evaluated. Lastly, this review paper examines the difficulties and potential future developments associated with utilizing DES-based FFs as extraction solvents.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"184 ","pages":"Article 118126"},"PeriodicalIF":11.8,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143157660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-28DOI: 10.1016/j.trac.2024.118120
Sujia Jiao , Long Wu , Huan Jiang , Sihang Zhang , Yu Han , Huang Huang
Mycotoxins, secondary metabolites derived from fungi, are identified as a major contributor to significant economic losses and a substantial threat to food safety and public health. There is an urgent need for rapid, simple, portable, and sensitive methods to detect mycotoxins in various stages, from the field to processing. Surface-enhanced Raman scattering (SERS) is a promising technique due to its high sensitivity and specificity, but it faces challenges such as stability, cost, and signal overlaps. To overcome these, SERS is integrated with other techniques like colorimetry, fluorescence, lateral flow immunochromatography assay (LFIA), and electrochemical detection, to enhance overall detection performance. This review discusses the effectiveness of SERS-based techniques in detecting mycotoxins and the construction of multimodal SERS sensors, which combine different principles to improve detection. Furthermore, the review anticipates the trajectory of advancements in SERS sensing techniques, outlining their prospective contributions to the field of mycotoxin detection.
{"title":"A review on SERS-based techniques for mycotoxin detection: From construction to application","authors":"Sujia Jiao , Long Wu , Huan Jiang , Sihang Zhang , Yu Han , Huang Huang","doi":"10.1016/j.trac.2024.118120","DOIUrl":"10.1016/j.trac.2024.118120","url":null,"abstract":"<div><div>Mycotoxins, secondary metabolites derived from fungi, are identified as a major contributor to significant economic losses and a substantial threat to food safety and public health. There is an urgent need for rapid, simple, portable, and sensitive methods to detect mycotoxins in various stages, from the field to processing. Surface-enhanced Raman scattering (SERS) is a promising technique due to its high sensitivity and specificity, but it faces challenges such as stability, cost, and signal overlaps. To overcome these, SERS is integrated with other techniques like colorimetry, fluorescence, lateral flow immunochromatography assay (LFIA), and electrochemical detection, to enhance overall detection performance. This review discusses the effectiveness of SERS-based techniques in detecting mycotoxins and the construction of multimodal SERS sensors, which combine different principles to improve detection. Furthermore, the review anticipates the trajectory of advancements in SERS sensing techniques, outlining their prospective contributions to the field of mycotoxin detection.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"184 ","pages":"Article 118120"},"PeriodicalIF":11.8,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143157663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Microfluidic technologies, which leverage the distinctive fluid properties at the nanoscale and microscale, are experiencing a surge in interest and advancements across various scientific fields. In particular, integrating nanotechnology with microfluidics has significantly enhanced the synthesis, production, and targeted delivery of biomedical compounds, especially through nanoparticles. Researchers are increasingly drawn to microfluidic devices due to their numerous advantages, which include high reproducibility, uniform structural characteristics, potential for cost reduction, and highly controllable fluid dynamics. The unique attributes of microfluidic systems enable drug delivery platforms to achieve stability, enhanced potency, and tailored release profiles, which are critical for effective therapeutic interventions. Despite the substantial progress made in the area of drug delivery utilizing microfluidics, there remain significant concerns regarding the quality and consistency of the materials produced. Among the various materials being explored, polysaccharides stand out as a vital component of the biopolymer family, attracting considerable attention for their favorable properties. These include biodegradability, widespread natural availability, non-toxic profiles, and low production costs. Such advantageous characteristics position polysaccharides as promising candidates for formulating drug delivery systems that can encapsulate and guard sensitive pharmaceutical agents while ensuring their controlled release at targeted sites within the body. Particularly noteworthy is alginate (AlgI), a polysaccharide derived from brown seaweed, which serves as a focal point in this discussion. This article specifically reviews the opportunities and challenges associated with AlgI in the context of microfluidic-assisted drug delivery. By systematically examining recent literature, the article aims to provide a comprehensive and current perspective on recent research and innovations in this domain. This includes exploring the design and formulation of high-performance drug delivery systems that utilize microfluidic techniques combined with stimuli-responsive features of AlgI, an area that has been relatively underexplored in existing studies.
{"title":"Recent advances in microfluidic technologies for stimuli-sensitive alginate particles: Applications in biosensing and drug delivery","authors":"Aliakbar Ebrahimiverkiani , Seyed Morteza Naghib , Ghobad Shafiei Sabet , Payam Arghavani , Mohammad Edrisi , Navid Rabiee","doi":"10.1016/j.trac.2024.118124","DOIUrl":"10.1016/j.trac.2024.118124","url":null,"abstract":"<div><div>Microfluidic technologies, which leverage the distinctive fluid properties at the nanoscale and microscale, are experiencing a surge in interest and advancements across various scientific fields. In particular, integrating nanotechnology with microfluidics has significantly enhanced the synthesis, production, and targeted delivery of biomedical compounds, especially through nanoparticles. Researchers are increasingly drawn to microfluidic devices due to their numerous advantages, which include high reproducibility, uniform structural characteristics, potential for cost reduction, and highly controllable fluid dynamics. The unique attributes of microfluidic systems enable drug delivery platforms to achieve stability, enhanced potency, and tailored release profiles, which are critical for effective therapeutic interventions. Despite the substantial progress made in the area of drug delivery utilizing microfluidics, there remain significant concerns regarding the quality and consistency of the materials produced. Among the various materials being explored, polysaccharides stand out as a vital component of the biopolymer family, attracting considerable attention for their favorable properties. These include biodegradability, widespread natural availability, non-toxic profiles, and low production costs. Such advantageous characteristics position polysaccharides as promising candidates for formulating drug delivery systems that can encapsulate and guard sensitive pharmaceutical agents while ensuring their controlled release at targeted sites within the body. Particularly noteworthy is alginate (AlgI), a polysaccharide derived from brown seaweed, which serves as a focal point in this discussion. This article specifically reviews the opportunities and challenges associated with AlgI in the context of microfluidic-assisted drug delivery. By systematically examining recent literature, the article aims to provide a comprehensive and current perspective on recent research and innovations in this domain. This includes exploring the design and formulation of high-performance drug delivery systems that utilize microfluidic techniques combined with stimuli-responsive features of AlgI, an area that has been relatively underexplored in existing studies.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"184 ","pages":"Article 118124"},"PeriodicalIF":11.8,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143157668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-27DOI: 10.1016/j.trac.2024.118121
Jia Wu , Yujie Li , Lijun Wang , Sang-Cuo Nao , Daniel Shiu-Hin Chan , Chun-Yuen Wong , Guanjun Yang , Wanhe Wang , Chung-Hang Leung
The G-quadruplex is a noncanonical secondary structure formed by guanine-rich nucleic acid sequences stabilized by metal ions. Multiple types of human health related target detection strategies have been developed based on the G-quadruplex motif, owing to its high structure stability and manipulability. These G-quadruplex DNA based biosensors exhibit high specificity and sensitivity in a variety of detection strategies. In recent years, microfluidic-based detection platforms are pushing the development of molecular detection forward due to their advantages of high-throughput, high integration, low reagent and time consumption, and portability. By integrating the strengths of both G-quadruplex DNA and microfluidics, G-quadruplex-based microfluidic biosensors are emerging as one of the cutting-edge research approaches. This review provides an overview of the detection strategies of G-quadruplex DNA-based biosensors and the classification of microfluidic technologies. It then focuses on the application of G-quadruplex-based microfluidics in the detection of human health-related ions and biomarkers, as well as its innovative applications as drug screening tools. At the end of this review, we discuss the advantages and current challenges of G-quadruplex-based microfluidic detection platforms.
{"title":"Microfluidic detection using G-quadruplex DNA-based biosensors","authors":"Jia Wu , Yujie Li , Lijun Wang , Sang-Cuo Nao , Daniel Shiu-Hin Chan , Chun-Yuen Wong , Guanjun Yang , Wanhe Wang , Chung-Hang Leung","doi":"10.1016/j.trac.2024.118121","DOIUrl":"10.1016/j.trac.2024.118121","url":null,"abstract":"<div><div>The G-quadruplex is a noncanonical secondary structure formed by guanine-rich nucleic acid sequences stabilized by metal ions. Multiple types of human health related target detection strategies have been developed based on the G-quadruplex motif, owing to its high structure stability and manipulability. These G-quadruplex DNA based biosensors exhibit high specificity and sensitivity in a variety of detection strategies. In recent years, microfluidic-based detection platforms are pushing the development of molecular detection forward due to their advantages of high-throughput, high integration, low reagent and time consumption, and portability. By integrating the strengths of both G-quadruplex DNA and microfluidics, G-quadruplex-based microfluidic biosensors are emerging as one of the cutting-edge research approaches. This review provides an overview of the detection strategies of G-quadruplex DNA-based biosensors and the classification of microfluidic technologies. It then focuses on the application of G-quadruplex-based microfluidics in the detection of human health-related ions and biomarkers, as well as its innovative applications as drug screening tools. At the end of this review, we discuss the advantages and current challenges of G-quadruplex-based microfluidic detection platforms.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"184 ","pages":"Article 118121"},"PeriodicalIF":11.8,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143157665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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