Trends in Analytical Chemistry最新文献

英文中文

Recent progress in Arduino- and smartphone-based sensors for biochemical and environmental analysis

IF 11.8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry

Pub Date : 2025-02-01 DOI: 10.1016/j.trac.2024.118103

Mirkomil Sharipov , Shakhzodjon Uzokboev , Nguyen Ngoc Nghia , Shavkatjon Azizov , WonHyoung Ryu , Salah M. Tawfik , Yong-Ill Lee

Recent SARS-CoV-2 pandemic and environmental disasters have emphasized the importance of rapid and efficient sensing platforms. Scientists have focused on developing portable sensing platforms to avoid using bulky and high-cost analytical equipment. Smartphones are the most accessible gadgets with integrated sensors to perform analytical analysis. However, the constant advances and competition in smartphones result in upgrades to smartphones, including their sensors, every year. Moreover, differences in smartphones’ sensor and image processing algorithms that vary from model to model complicate the standardization of readers. Arduino microcontroller-based readers have been investigated as an alternative to the smartphone data reader. Although Arduino-based sensors are not as portable as smartphones and cannot perform other tasks than they are developed and programmed for, they are usually built from a limited number of components, thus simplifying their standardization. In this review, we outline the different approaches used to develop smartphone-based analytical sensors and the development of Arduino-based sensors. These approaches will mainly focus on developing novel sensing platforms, the choice of smartphone sensors, and data processing methods. We also discuss the application of smartphone- and Arduino-based sensors for biochemical and environmental monitoring.

{"title":"Recent progress in Arduino- and smartphone-based sensors for biochemical and environmental analysis","authors":"Mirkomil Sharipov , Shakhzodjon Uzokboev , Nguyen Ngoc Nghia , Shavkatjon Azizov , WonHyoung Ryu , Salah M. Tawfik , Yong-Ill Lee","doi":"10.1016/j.trac.2024.118103","DOIUrl":"10.1016/j.trac.2024.118103","url":null,"abstract":"<div><div>Recent SARS-CoV-2 pandemic and environmental disasters have emphasized the importance of rapid and efficient sensing platforms. Scientists have focused on developing portable sensing platforms to avoid using bulky and high-cost analytical equipment. Smartphones are the most accessible gadgets with integrated sensors to perform analytical analysis. However, the constant advances and competition in smartphones result in upgrades to smartphones, including their sensors, every year. Moreover, differences in smartphones’ sensor and image processing algorithms that vary from model to model complicate the standardization of readers. Arduino microcontroller-based readers have been investigated as an alternative to the smartphone data reader. Although Arduino-based sensors are not as portable as smartphones and cannot perform other tasks than they are developed and programmed for, they are usually built from a limited number of components, thus simplifying their standardization. In this review, we outline the different approaches used to develop smartphone-based analytical sensors and the development of Arduino-based sensors. These approaches will mainly focus on developing novel sensing platforms, the choice of smartphone sensors, and data processing methods. We also discuss the application of smartphone- and Arduino-based sensors for biochemical and environmental monitoring.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"183 ","pages":"Article 118103"},"PeriodicalIF":11.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in microplastic characterization: Spectroscopic techniques and heavy metal adsorption insights

IF 11.8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry

Pub Date : 2025-02-01 DOI: 10.1016/j.trac.2024.118111

M. Vasudeva , Anish Kumar Warrier , V.B. Kartha , V.K. Unnikrishnan

Microplastics (MPs) have become a matter of very serious concern as environmental pollutants nowadays because of the humongous increased production, use-and-discard nature associated with them, and the contamination of the environment with micro- and nano-plastics and other pollutants carried over by them, like many heavy metals, organic species, etc. Researchers have employed various techniques for detecting and classifying microplastics, mainly based on their optical or mass spectra or specific mass. This article discusses the various techniques used to characterize microplastics and surface-adsorbed heavy metals. Conventional techniques like Fourier Transform Infrared (FTIR) spectroscopy and Raman spectroscopy are widely used to identify the class of MPs and provide details about the extent of pollution. Heavy metals are one of the other environmental contaminants that can cause severe health issues. The microplastics act as a vector for transporting heavy metals from different locations and induce a potentiating effect. To identify the heavy metals adsorbed onto the MPs, various techniques such as Inductively Coupled Plasma Mass Spectrometry (ICP-MS), Energy Dispersive X-ray Spectroscopy (SEM-EDS), and others are used. After a review of the current identification approaches, which require the utilization of multiple resources and expertise for microplastic characterization and their surface-adsorbed heavy metal detection, the recent development of a single multi-modal spectroscopy system, capable of identifying both molecular and elemental information, which serve the purpose of microplastics and surface-adsorbed heavy metal identification in short times, enabling rapid screening and classification of samples, is discussed. Novel methods using such multi-modal systems-containing Laser-Induced Breakdown Spectroscopy (LIBS)/and Raman/fluorescence spectroscopy-under a single platform will come in handy in the future for the complete analysis of the microplastic samples for plastic classification and heavy metal detection.

{"title":"Advances in microplastic characterization: Spectroscopic techniques and heavy metal adsorption insights","authors":"M. Vasudeva , Anish Kumar Warrier , V.B. Kartha , V.K. Unnikrishnan","doi":"10.1016/j.trac.2024.118111","DOIUrl":"10.1016/j.trac.2024.118111","url":null,"abstract":"<div><div>Microplastics (MPs) have become a matter of very serious concern as environmental pollutants nowadays because of the humongous increased production, use-and-discard nature associated with them, and the contamination of the environment with micro- and nano-plastics and other pollutants carried over by them, like many heavy metals, organic species, etc. Researchers have employed various techniques for detecting and classifying microplastics, mainly based on their optical or mass spectra or specific mass. This article discusses the various techniques used to characterize microplastics and surface-adsorbed heavy metals. Conventional techniques like Fourier Transform Infrared (FTIR) spectroscopy and Raman spectroscopy are widely used to identify the class of MPs and provide details about the extent of pollution. Heavy metals are one of the other environmental contaminants that can cause severe health issues. The microplastics act as a vector for transporting heavy metals from different locations and induce a potentiating effect. To identify the heavy metals adsorbed onto the MPs, various techniques such as Inductively Coupled Plasma Mass Spectrometry (ICP-MS), Energy Dispersive X-ray Spectroscopy (SEM-EDS), and others are used. After a review of the current identification approaches, which require the utilization of multiple resources and expertise for microplastic characterization and their surface-adsorbed heavy metal detection, the recent development of a single multi-modal spectroscopy system, capable of identifying both molecular and elemental information, which serve the purpose of microplastics and surface-adsorbed heavy metal identification in short times, enabling rapid screening and classification of samples, is discussed. Novel methods using such multi-modal systems-containing Laser-Induced Breakdown Spectroscopy (LIBS)/and Raman/fluorescence spectroscopy-under a single platform will come in handy in the future for the complete analysis of the microplastic samples for plastic classification and heavy metal detection.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"183 ","pages":"Article 118111"},"PeriodicalIF":11.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-invasive nanozyme sensors for urinalysis

IF 11.8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry

Pub Date : 2025-02-01 DOI: 10.1016/j.trac.2024.118100

Sanjana Naveen Prasad, Vipul Bansal, Rajesh Ramanathan

Biomolecules in body fluids serve as biomarkers or early indicators of diseases while offering opportunities to monitor disease progression and track the effectiveness of treatments. Urinalysis can potentially detect early signs of disease, as the body eliminates harmful substances and molecules because of its homeostasis mechanism. This would mean that the relevant concentrations of such markers remain unchanged in the blood while manifesting themselves first in the urine. This highlights the need to improve sensor capabilities for urinalysis. Although urinalysis sensors (typically enzyme-based or a combination of antibody and enzymes) have seen limited commercial success, there is a critical need for new sensing technologies to improve sensor sensitivity, selectivity, and accuracy. To this end, nanozymes, nanomaterials mimicking the catalytic activity of enzymes (a large majority mimicking oxidoreductase enzymes), can detect clinically significant urinary biomarkers with minimal interference from the sample matrix and demonstrate superior sensor performance across a wide range of pH and temperature conditions, making them ideal for the development of portable point-of-care testing devices. This review attempts to critically evaluate the strategies used in nanozyme sensors, recognise if the strategy is capable of detecting urinary biomarkers in the physiologically relevant range, and finally identify the key challenges that need to be addressed before nanozyme-based sensors can be used in clinical settings.

{"title":"Non-invasive nanozyme sensors for urinalysis","authors":"Sanjana Naveen Prasad, Vipul Bansal, Rajesh Ramanathan","doi":"10.1016/j.trac.2024.118100","DOIUrl":"10.1016/j.trac.2024.118100","url":null,"abstract":"<div><div>Biomolecules in body fluids serve as biomarkers or early indicators of diseases while offering opportunities to monitor disease progression and track the effectiveness of treatments. Urinalysis can potentially detect early signs of disease, as the body eliminates harmful substances and molecules because of its homeostasis mechanism. This would mean that the relevant concentrations of such markers remain unchanged in the blood while manifesting themselves first in the urine. This highlights the need to improve sensor capabilities for urinalysis. Although urinalysis sensors (typically enzyme-based or a combination of antibody and enzymes) have seen limited commercial success, there is a critical need for new sensing technologies to improve sensor sensitivity, selectivity, and accuracy. To this end, nanozymes, nanomaterials mimicking the catalytic activity of enzymes (a large majority mimicking oxidoreductase enzymes), can detect clinically significant urinary biomarkers with minimal interference from the sample matrix and demonstrate superior sensor performance across a wide range of pH and temperature conditions, making them ideal for the development of portable point-of-care testing devices. This review attempts to critically evaluate the strategies used in nanozyme sensors, recognise if the strategy is capable of detecting urinary biomarkers in the physiologically relevant range, and finally identify the key challenges that need to be addressed before nanozyme-based sensors can be used in clinical settings.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"183 ","pages":"Article 118100"},"PeriodicalIF":11.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetic-based microextraction systems for the determination of emerging contaminants in environmental liquid samples

IF 11.8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry

Pub Date : 2025-02-01 DOI: 10.1016/j.trac.2024.118116

Tanausú Vega-Morales , Zoraida Sosa-Ferrera , José Juan Santana-Rodríguez , Sarah Montesdeoca-Esponda

The development of novel methodologies for the extraction of emerging contaminants (ECs) based on functionalized magnetic nanoparticles (MNPs) has increased over the past decade. The properties of these materials permit rapid and efficient separation of the adsorbents and/or solvents used as extractants by the application of a magnetic field, avoiding the use of time-consuming and expensive processes. Due to their high surface areas, ease of modification with different materials, and integration with conventional solid-phase extraction systems, such nanoadsorbents are candidates for developing efficient microextraction methods. Furthermore, they can be easily automated and aligned with green chemistry principles, reducing the environmental impact generated in the synthesis of the nanoparticles and their subsequent application. This critical review focuses on the use of MNPs composites in microextraction systems employed for the determination of ECs in liquid environmental matrices over the past 10 years, including pharmaceuticals, personal care products, plasticizers and industrial chemicals and microplastics.

{"title":"Magnetic-based microextraction systems for the determination of emerging contaminants in environmental liquid samples","authors":"Tanausú Vega-Morales , Zoraida Sosa-Ferrera , José Juan Santana-Rodríguez , Sarah Montesdeoca-Esponda","doi":"10.1016/j.trac.2024.118116","DOIUrl":"10.1016/j.trac.2024.118116","url":null,"abstract":"<div><div>The development of novel methodologies for the extraction of emerging contaminants (ECs) based on functionalized magnetic nanoparticles (MNPs) has increased over the past decade. The properties of these materials permit rapid and efficient separation of the adsorbents and/or solvents used as extractants by the application of a magnetic field, avoiding the use of time-consuming and expensive processes. Due to their high surface areas, ease of modification with different materials, and integration with conventional solid-phase extraction systems, such nanoadsorbents are candidates for developing efficient microextraction methods. Furthermore, they can be easily automated and aligned with green chemistry principles, reducing the environmental impact generated in the synthesis of the nanoparticles and their subsequent application. This critical review focuses on the use of MNPs composites in microextraction systems employed for the determination of ECs in liquid environmental matrices over the past 10 years, including pharmaceuticals, personal care products, plasticizers and industrial chemicals and microplastics.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"183 ","pages":"Article 118116"},"PeriodicalIF":11.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143104754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The oxygen isotopic composition of tooth enamel carbonate: A review of measurement methods & forensic applications

IF 11.8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry

Pub Date : 2025-02-01 DOI: 10.1016/j.trac.2024.118084

Daniel L. Johnson , Thuan H. Chau , Lesley A. Chesson

Oxygen isotopes in tooth enamel carbonate are commonly measured in studies of ecology, paleoclimate, and provenance; however, methods for sample pretreatment and mass spectrometric analysis widely vary. Here, we advocate for the development of a standardized protocol for oxygen isotope ratio analysis of tooth enamel carbonate that would be particularly suited for forensic applications. To do this, we review primarily the archaeological literature and highlight applications of tooth enamel carbonate data explored in previous studies; we also examine potential challenges for using these data in forensic contexts. Despite the demonstrated utility of oxygen isotopic data for tooth enamel carbonate, we find that variations in sample preparation and measurement methodologies can dramatically hinder the development of robust forensic applications. We encourage adoption of a standardized approach to facilitate the routine generation of oxygen isotopic data for forensic identification purposes and to improve data comparability among analytical facilities moving forward.

{"title":"The oxygen isotopic composition of tooth enamel carbonate: A review of measurement methods & forensic applications","authors":"Daniel L. Johnson , Thuan H. Chau , Lesley A. Chesson","doi":"10.1016/j.trac.2024.118084","DOIUrl":"10.1016/j.trac.2024.118084","url":null,"abstract":"<div><div>Oxygen isotopes in tooth enamel carbonate are commonly measured in studies of ecology, paleoclimate, and provenance; however, methods for sample pretreatment and mass spectrometric analysis widely vary. Here, we advocate for the development of a standardized protocol for oxygen isotope ratio analysis of tooth enamel carbonate that would be particularly suited for forensic applications. To do this, we review primarily the archaeological literature and highlight applications of tooth enamel carbonate data explored in previous studies; we also examine potential challenges for using these data in forensic contexts. Despite the demonstrated utility of oxygen isotopic data for tooth enamel carbonate, we find that variations in sample preparation and measurement methodologies can dramatically hinder the development of robust forensic applications. We encourage adoption of a standardized approach to facilitate the routine generation of oxygen isotopic data for forensic identification purposes and to improve data comparability among analytical facilities moving forward.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"183 ","pages":"Article 118084"},"PeriodicalIF":11.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in porous organic framework-based aptasensors for diagnosis of cancer diseases

IF 11.8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry

Pub Date : 2025-02-01 DOI: 10.1016/j.trac.2024.118106

Abdelmonaim Azzouz , Lamia Hejji , Ki-Hyun Kim

The detection of biomarkers present in biological fluids (e.g., serum, blood, saliva, and urine) is the primary step for the early diagnosis of associated diseases. In this context, the great utility of porous organic frameworks (POFs), including metal, covalent, and hydrogen-bonding organic frameworks, is recognized. These frameworks in combination with aptamers can be utilized in diagnostic sensing against a range of biomarkers such as prostate-specific antigens, carcinoembryonic antigens, alpha-fetoprotein, mucin 1, human epidermal growth factor receptor 2, and exosomes. This article outlines the recent breakthroughs in advancing aptamer-functionalized POFs for the sensing of cancer biomarkers with respect to sensing principles, sensing mechanisms (including POFs directly as signal probes or as carriers for loading signal probes), and performance (with a focus on sensitivity). Finally, the challenges and prospects related to the development of aptamer-functionalized POFs are discussed for their upscaled sensing application toward cancer biomarkers in real biological samples.

引用次数: 0

Plasmon-enhanced fluorescence (bio)sensors and other bioanalytical technologies

IF 11.8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry

Pub Date : 2025-02-01 DOI: 10.1016/j.trac.2024.118060

Dario Cattozzo Mor , Gizem Aktug , Katharina Schmidt , Prasanth Asokan , Naoto Asai , Chun-Jen Huang , Jakub Dostalek

Advances in the plasmon-enhanced fluorescence method and its implementations in optical sensors, biosensors, and other types of bioanalytical technologies are discussed in this paper. In particular, the focus is given to the results that have been achieved over the last ten years concerning the design and preparation of metallic nanostructures tailored for the amplification of weak fluorescence signals and their utilization in the field of ultrasensitive detection and identification of chemical and biological species. Applications and performance characteristics of plasmon-enhanced fluorescence in the areas of analysis of biomarkers for disease diagnostics, cell imaging, environmental monitoring of harmful compounds, and single molecule analysis are critically reviewed.

引用次数: 0

Electroconductive polymer-based biosensors for early cancer detection via liquid biopsy: Advances, challenges, and future prospects

IF 11.8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry

Pub Date : 2025-02-01 DOI: 10.1016/j.trac.2024.118062

Babak Mikaeeli Kangarshahi , Soheil Sojdeh , Hossein Daneshgar , Mojtaba Bagherzadeh , Seyed Morteza Naghib , Navid Rabiee

Early detection and treatment significantly improve the survival rates and overall health outcomes of cancer patients, making them critical factors in reducing the global mortality rate. Electrochemical biosensors have the capability to detect a wide range of cancer biomarkers—including DNA, RNA, proteins, enzymes, and cells—in biological samples. Conductive polymers, which possess unique electrical and optical properties, can enhance the performance of these biosensors. They provide a biocompatible surface for biomolecule attachment, facilitate electron transport between the electrode and analyte, and amplify signals through their electroactive properties or by integrating functional nanomaterials. This review offers a comprehensive overview of recent advances in the development of electrochemical biosensors utilizing conductive polymers and their composites for cancer biomarker detection. It explores the benefits and challenges associated with various conductive polymers, such as polyaniline, polypyrrole, polythiophene, and poly (3,4-ethylenedioxythiophene) (PEDOT), alongside their fabrication techniques, including electrodeposition, chemical polymerization, and spin coating. Additionally, strategies to enhance the sensitivity, selectivity, stability, and reproducibility of these biosensors—such as the use of aptamers, nanoparticles, nanocomposites, and multiplexing—are discussed. The review also considers the future potential and challenges of employing electrochemical biosensors based on conductive polymers in cancer detection.

{"title":"Electroconductive polymer-based biosensors for early cancer detection via liquid biopsy: Advances, challenges, and future prospects","authors":"Babak Mikaeeli Kangarshahi , Soheil Sojdeh , Hossein Daneshgar , Mojtaba Bagherzadeh , Seyed Morteza Naghib , Navid Rabiee","doi":"10.1016/j.trac.2024.118062","DOIUrl":"10.1016/j.trac.2024.118062","url":null,"abstract":"<div><div>Early detection and treatment significantly improve the survival rates and overall health outcomes of cancer patients, making them critical factors in reducing the global mortality rate. Electrochemical biosensors have the capability to detect a wide range of cancer biomarkers—including DNA, RNA, proteins, enzymes, and cells—in biological samples. Conductive polymers, which possess unique electrical and optical properties, can enhance the performance of these biosensors. They provide a biocompatible surface for biomolecule attachment, facilitate electron transport between the electrode and analyte, and amplify signals through their electroactive properties or by integrating functional nanomaterials. This review offers a comprehensive overview of recent advances in the development of electrochemical biosensors utilizing conductive polymers and their composites for cancer biomarker detection. It explores the benefits and challenges associated with various conductive polymers, such as polyaniline, polypyrrole, polythiophene, and poly (3,4-ethylenedioxythiophene) (PEDOT), alongside their fabrication techniques, including electrodeposition, chemical polymerization, and spin coating. Additionally, strategies to enhance the sensitivity, selectivity, stability, and reproducibility of these biosensors—such as the use of aptamers, nanoparticles, nanocomposites, and multiplexing—are discussed. The review also considers the future potential and challenges of employing electrochemical biosensors based on conductive polymers in cancer detection.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"183 ","pages":"Article 118062"},"PeriodicalIF":11.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143104741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advancements in biosensors for diagnosis of ovarian cancer: Analytical approaches

IF 11.8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry

Pub Date : 2025-02-01 DOI: 10.1016/j.trac.2024.118119

Amin Foroozandeh , Mojtaba Afshari Babazad , Shirzad Jouybar , Majid Abdouss , Hossein Salar Amoli , Kheibar Dashtian , Mohammad Hasanzadeh

Ovarian cancer (OC) remains one of the deadliest malignancies affecting women globally, with a high mortality rate largely because of the absence of efficient early detection approaches. Biomarkers offer significant promise for improving OC diagnostic accuracy and facilitating non-invasive, early-stage detection. This review surveyed recent advancements in nano-biosensing strategies for OC detection through the monitoring of genomic, transcriptomic, proteomic, and metabolomic biomarkers, including CA125, HE4, and CEA. It provides a critical analysis of sensing transducer species (e.g., metallic nanoparticles, MXenes, metal-organic frameworks, quantum dots, metal chalcogenides, metal oxides, conductive polymers), recognition elements (e.g., aptamers, antibodies), assay formats (direct, inhibition, and competitive), signal generators , and signaling methods employed in electrochemical and optical techniques. These technologies offer complementary advantages in detecting trace biomarker levels with high sensitivity and specificity. The review further explores emerging technologies, such as lateral flow assay and microfluidics, which have the potential to revolutionize wearable devices for monitoring OC biomarkers in human biofluids toward point-of-care diagnostic of cancer. It is anticipated that advanced nano-biosensing technologies integrating AI will enable rapid, highly accurate identification of OC , enhancing early detection and improving patient outcomes.

{"title":"Recent advancements in biosensors for diagnosis of ovarian cancer: Analytical approaches","authors":"Amin Foroozandeh , Mojtaba Afshari Babazad , Shirzad Jouybar , Majid Abdouss , Hossein Salar Amoli , Kheibar Dashtian , Mohammad Hasanzadeh","doi":"10.1016/j.trac.2024.118119","DOIUrl":"10.1016/j.trac.2024.118119","url":null,"abstract":"<div><div>Ovarian cancer (OC) remains one of the deadliest malignancies affecting women globally, with a high mortality rate largely because of the absence of efficient early detection approaches. Biomarkers offer significant promise for improving OC diagnostic accuracy and facilitating non-invasive, early-stage detection. This review surveyed recent advancements in nano-biosensing strategies for OC detection through the monitoring of genomic, transcriptomic, proteomic, and metabolomic biomarkers, including CA125, HE4, and CEA. It provides a critical analysis of sensing transducer species (<em>e.g.,</em> metallic nanoparticles, MXenes, metal-organic frameworks, quantum dots, metal chalcogenides, metal oxides, conductive polymers), recognition elements (<em>e.g.,</em> aptamers, antibodies), assay formats (direct, inhibition, and competitive), signal generators , and signaling methods employed in electrochemical and optical techniques. These technologies offer complementary advantages in detecting trace biomarker levels with high sensitivity and specificity. The review further explores emerging technologies, such as lateral flow assay and microfluidics, which have the potential to revolutionize wearable devices for monitoring OC biomarkers in human biofluids toward point-of-care diagnostic of cancer. It is anticipated that advanced nano-biosensing technologies integrating AI will enable rapid, highly accurate identification of OC , enhancing early detection and improving patient outcomes.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"183 ","pages":"Article 118119"},"PeriodicalIF":11.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143104755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends in the use of argonaute proteins in molecular diagnosis

IF 11.8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry

Pub Date : 2025-02-01 DOI: 10.1016/j.trac.2024.118081

Hanxue Li , Fangyuan Zheng , Zhejun Yang , Fei Cun , Kexin Wu , Weican Chen , Bin Yang , Jilie Kong , Hui Chen

Argonaute proteins (Agos) have emerged as key tools in molecular diagnosis because of their ability to precisely target specific bases and perform multi-target cleavage. Previous reviews on Agos mainly covered their roles in nucleic acid detection and biological functions. However, recent advances in molecular diagnostics have led to the development of new technologies, methods, platforms, and targets using Agos. This review provides a succinct overview of Agos, including their classification, structural domains, and functional mechanisms, with a focus on recent advancements in Ago-based biosensors for molecular diagnosis from 2019 to 2024. The signal transduction strategies used in Ago-based biosensors and novel technological applications are reviewed and discussed, exploring methods to achieve high sensitivity and the multiplex detection of nucleic acids and non-nucleic acid biomarkers (such as proteins and small molecules). We also present our perspectives on the future development and challenges in creating next-generation molecular diagnostic technologies based on Agos.

{"title":"Trends in the use of argonaute proteins in molecular diagnosis","authors":"Hanxue Li , Fangyuan Zheng , Zhejun Yang , Fei Cun , Kexin Wu , Weican Chen , Bin Yang , Jilie Kong , Hui Chen","doi":"10.1016/j.trac.2024.118081","DOIUrl":"10.1016/j.trac.2024.118081","url":null,"abstract":"<div><div>Argonaute proteins (Agos) have emerged as key tools in molecular diagnosis because of their ability to precisely target specific bases and perform multi-target cleavage. Previous reviews on Agos mainly covered their roles in nucleic acid detection and biological functions. However, recent advances in molecular diagnostics have led to the development of new technologies, methods, platforms, and targets using Agos. This review provides a succinct overview of Agos, including their classification, structural domains, and functional mechanisms, with a focus on recent advancements in Ago-based biosensors for molecular diagnosis from 2019 to 2024. The signal transduction strategies used in Ago-based biosensors and novel technological applications are reviewed and discussed, exploring methods to achieve high sensitivity and the multiplex detection of nucleic acids and non-nucleic acid biomarkers (such as proteins and small molecules). We also present our perspectives on the future development and challenges in creating next-generation molecular diagnostic technologies based on Agos.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"183 ","pages":"Article 118081"},"PeriodicalIF":11.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143104750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

首页上一页

下一页尾页

类型

全部化学•材料生命科学医学物理工程技术环境•农林材料科学地球科学法学管理学化学环境科学与生态学计算机科学教育学经济学农林科学人文科学生物学数学物理与天体物理心理学综合性期刊其他工业工程理学历史学农学文学信息工程

数据库

全部 ACS Publications Elsevier ieeexplore Springer The Royal Society of Chemistry Wiley

期刊

Trends in Analytical Chemistry

全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.

﹀