Trends in Analytical Chemistry最新文献

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Applications of stable isotopes in lipid metabolic tracing and lipidomics analysis 稳定同位素在脂质代谢示踪和脂质组学分析中的应用

IF 12 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry

Pub Date : 2025-12-25 DOI: 10.1016/j.trac.2025.118629

Zhuoning Xie , Simin Cheng , Xiaoyun Gong , Xiaoxiao Ma

Lipids are structurally diverse and functionally critical biomolecules playing key roles in energy storage, signal transduction, and membrane formation. Their precise regulation is essential for cellular homeostasis, with metabolic disruptions closely linked to conditions like atherosclerosis and diabetes, while lipid metabolic reprogramming has emerged as a hallmark of cancer. This review outlines recent advances in applying stable isotopes for lipid metabolic tracing, lipidomics analysis, and flux quantification. It discusses various labeling strategies and reviews dynamic characterization models such as mass isotopomer distribution (MID), carbon-average enrichment, isotopomer spectral analysis (ISA), and ¹³C-nonstationary metabolic flux analysis (¹³C-NMFA). The applications of isotope tracing in baseline metabolism, disease-induced reprogramming, and pharmacology are examined, alongside advancements in mass spectrometry imaging and single-cell lipidomics. Ultimately, stable isotope tracing offers a dynamic perspective for lipid metabolism, enabling the tracking of real-time pathway changes and metabolic fluxes. Combined with advanced mass spectrometry, this approach should significantly expand the understanding of physiology and disease mechanisms, highlighting its potential in pharmacological research and future developments in multimodal data integration and AI-driven spatiotemporal modeling.

脂质是一种结构多样、功能关键的生物分子，在能量储存、信号转导和膜形成中起着关键作用。它们的精确调节对细胞内稳态至关重要，代谢紊乱与动脉粥样硬化和糖尿病等疾病密切相关，而脂质代谢重编程已成为癌症的标志。本文综述了稳定同位素在脂质代谢追踪、脂质组学分析和通量定量方面的最新进展。讨论了各种标记策略，并综述了动态表征模型，如质量同位素分布（MID）、碳平均富集、同位素谱分析（ISA）和13c -非平稳代谢通量分析（13C-NMFA）。同位素示踪在基线代谢、疾病诱导重编程和药理学方面的应用，以及质谱成像和单细胞脂质组学的进展。最终，稳定同位素示踪为脂质代谢提供了一个动态的视角，能够实时跟踪途径变化和代谢通量。结合先进的质谱分析，这种方法将大大扩展对生理和疾病机制的理解，突出其在药理学研究和未来多模态数据集成和人工智能驱动的时空建模方面的发展潜力。

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引用次数: 0

Recent progress in microfluidic cell manipulation techniques and their applications in single-cell mass spectrometry 微流控细胞操作技术及其在单细胞质谱分析中的应用进展

IF 12 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry

Pub Date : 2025-12-25 DOI: 10.1016/j.trac.2025.118630

Siyuan Tan , Huiping Qiao , Xuping Shentu , Zehu Xie , Yu Wang , Qionglin Liang , Xiaoyun Gong , Xinhua Dai

With the accelerated advancement of biotechnology, microfluidic cell manipulation has emerged as a focal research area. Microfluidics leverages microscale channels to achieve precise control of fluids with high throughput, cost-effectiveness, and miniaturization. It makes use of the unique properties of fluids for single-cell manipulation and analysis with unprecedented accuracy and efficiency. With the advantages of high sensitivity, wide molecular coverage and excellent structural identification, mass spectrometry (MS) stands as a powerful tool for both qualitative and quantitative analysis of a vast range of biomolecules within single cells. In recent years, the integration of microfluidics and MS has gained significant attention, offering unprecedented precision and efficiency for single-cell studies. This review summarizes recent advances in microfluidic cell manipulation techniques and their integration with single-cell MS. The application scope covers multiple omics fields, including proteomics, metabolomics, lipidomics, metallomics, genomics, and transcriptomics. The review also discusses current challenges, outlines future research directions, and underscores the significance of this interdisciplinary area in biology, medicine, and environmental researches.

随着生物技术的飞速发展，微流控细胞技术已成为研究的热点。微流体利用微尺度通道来实现流体的精确控制，具有高通量，成本效益和小型化。它利用流体的独特特性，以前所未有的精度和效率进行单细胞操作和分析。质谱法（MS）具有灵敏度高、分子覆盖范围广、结构鉴定能力强等优点，是对单细胞内大量生物分子进行定性和定量分析的有力工具。近年来，微流体和质谱的结合得到了广泛的关注，为单细胞研究提供了前所未有的精度和效率。本文综述了微流控细胞操作技术及其与单细胞质谱结合的最新进展，其应用范围涵盖多个组学领域，包括蛋白质组学、代谢组学、脂质组学、金属组学、基因组学和转录组学。本文还讨论了当前的挑战，概述了未来的研究方向，并强调了这一跨学科领域在生物学、医学和环境研究中的重要性。

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引用次数: 0

Molecular design of metal complex-based luminescence probes for time-gated luminescence bioassays 用于时间门控发光生物测定的金属配合物发光探针的分子设计

IF 12 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry

Pub Date : 2025-12-24 DOI: 10.1016/j.trac.2025.118627

Yundi Huang , Bo Song , Wenzhu Zhang , Jingli Yuan

Metal complex-based time-gated luminescence (TGL) probes have become powerful tools for selective biomarker detection in biological systems. Leveraging long-lived luminescence from lanthanide (Eu³⁺, Tb³⁺) and transition-metal (Ru²⁺, Ir³⁺) complexes, TGL probes allow the autofluorescence to be eliminated, remarkably enhancing the signal-to-background ratio. This review summarizes the molecular strategies for the design of TGL probes, including metal ion selection, ligand engineering, and energy transfer modulation, as well as the principles guiding the incorporation of recognition and targeting groups. Their applications in multi-modal imaging systems, such as TGL-photoluminescence lifetime imaging (PLIM) and TGL-magnetic resonance imaging (MRI), were also discussed, giving an overview of the developments in metal complex-based probes and their bioassay applications.

金属配合物时间门控发光（TGL）探针已成为生物系统中选择性检测生物标志物的有力工具。利用镧系元素（Eu3+, Tb3+）和过渡金属（Ru2+, Ir3+）配合物的长寿命发光，TGL探针可以消除自身荧光，显著提高信本比。本文综述了TGL探针设计的分子策略，包括金属离子选择、配体工程和能量转移调制，以及识别和靶向基团的引入原则。本文还讨论了它们在多模态成像系统中的应用，如tgl -光致发光寿命成像（PLIM）和tgl -磁共振成像（MRI），概述了金属配合物探针及其生物测定应用的发展。

引用次数: 0

Probing interfacial electrochemical processes in metal biodegradation via in operando pH microscopy: A review with perspectives 利用酸碱度显微镜探测金属生物降解中的界面电化学过程：综述与展望

IF 12 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry

Pub Date : 2025-12-24 DOI: 10.1016/j.trac.2025.118619

Cheng Wang , Qiangsheng Dong , Yi Shao , Yulong Wu , Yanbin Zhao , Ming Yin , Di Mei , Chenglin Chu , Feng Xue , Jing Bai , Mikhail L. Zheludkevich , Sviatlana V. Lamaka

Metal biodegradation is primarily an electrochemical process, involving metal anodic dissolution and cathodic reduction of water or oxygen. The hydrolysis of metal cations produces H⁺ ions, while the cathodic reactions generate OH⁻ ions, inducing the changes in local pH. These pH variations are also influenced by the precipitation of chemical species on a metal surface. To monitor the local pH evolution, pH microelectrodes are placed in an electrolyte solution above the active surface (10–100 μm). This technique plays a crucial role in discerning the chemical nature of degradation products and getting insights on the kinetics of coupled electrochemical-chemical processes, especially in complex media during the degradation of biodegradable metals. This review provides an introduction to pH microscopy, presents several application examples in biodegradation-related studies, and discusses the simultaneous utilization of pH microscopy with other local techniques.

金属生物降解主要是一个电化学过程，涉及金属的阳极溶解和水或氧的阴极还原。金属阳离子的水解产生H+离子，而阴极反应产生OH−离子，引起局部pH的变化。这些pH变化也受到金属表面化学物质沉淀的影响。为了监测局部pH值的变化，pH微电极被放置在活性表面（10-100 μm）以上的电解质溶液中。该技术在识别降解产物的化学性质和了解耦合电化学-化学过程动力学方面起着至关重要的作用，特别是在复杂介质中降解生物可降解金属的过程中。本文介绍了pH显微镜的基本概念，介绍了pH显微镜在生物降解相关研究中的几个应用实例，并讨论了pH显微镜与其他局部技术的同时应用。

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引用次数: 0

Recent advancements in molecular diagnostics with nanomaterials 纳米材料在分子诊断中的最新进展

IF 12 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry

Pub Date : 2025-12-23 DOI: 10.1016/j.trac.2025.118605

Jing Li , Jiao Hu , Dai-Wen Pang , Cui Liu

Molecular diagnostics provides crucial information for disease prediction, prevention, diagnosis, and prognosis by detecting the presence, structural changes, or variations in the expression and regulation of biological macromolecules and macromolecular systems in the human body. Nanomaterials possess unique optical, magnetic, electrical, and thermal properties, which enable them to generate various detectable signals, amplify the intensity of detection signals, and simplify the detection process. This review summarizes the current applications and future development of nanomaterials in molecular diagnostics. It focuses on introducing the integration of nanomaterials with biochemical technologies, such as nucleic acid hybridization, nucleic acid amplification, CRISPR/Cas systems, immunoassay, and aptamers for molecular diagnostics. We explore the advantages and limitations of each integration method and evaluate their clinical applications or potential. This review offers a broad perspective on the prospects of nanomaterial-based molecular diagnostic technologies and highlights the potential future directions.

分子诊断通过检测人体内生物大分子和大分子系统的存在、结构变化或表达和调节的变化，为疾病预测、预防、诊断和预后提供重要信息。纳米材料具有独特的光学、磁性、电学和热学性质，使其能够产生各种可检测信号，放大检测信号的强度，简化检测过程。本文综述了纳米材料在分子诊断中的应用现状及发展前景。重点介绍纳米材料与生物化学技术的整合，如核酸杂交、核酸扩增、CRISPR/Cas系统、免疫测定和分子诊断适体。我们将探讨每种整合方法的优点和局限性，并评估其临床应用或潜力。本文综述了基于纳米材料的分子诊断技术的发展前景，并指出了未来的发展方向。

引用次数: 0

Molecular biosensors for detection of miRNA and its application in medical diagnosis 分子生物传感器检测miRNA及其在医学诊断中的应用

IF 12 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry

Pub Date : 2025-12-23 DOI: 10.1016/j.trac.2025.118626

Mehdi Dadmehr , Mehrana Allahverdi , Noosha Khalighi Kalat , Bahar Sheikhnejad , Morteza Hosseini

Regulatory microRNAs (miRNAs) are single-stranded RNA molecules, approximately 18–25 nucleotides in length, that do not code the proteins. They have gained attention as potential biomarkers for the diagnosis of cancer. Numerous biosensors have focused on development of point-of-care biosensors for the detection of miRNAs. Molecular biosensors had the potential to overcome the challenges include sample preparation, matrix effects and system integration in medical application. Several molecular strategies have been developed to address these challenges. The molecular strategies including HCR, RCA, LAMP, CHA, SDA and CRISPR are among the approaches that relies on the molecular detection in miRNA biosensors. In this review, we have described recent advancements in the field of molecular biosensors for detection of miRNAs, and also discuss and compare the feasibility and performance of different strategies applied in platform of the molecular biosensors. Also, applicability of proposed biosensors has been considered to compare their clinical results.

调控microrna （mirna）是单链RNA分子，长度约为18-25个核苷酸，不编码蛋白质。它们作为癌症诊断的潜在生物标志物而受到关注。许多生物传感器都专注于开发用于检测mirna的即时生物传感器。分子生物传感器在医学应用中具有克服样品制备、基质效应和系统集成等挑战的潜力。已经开发了几种分子策略来应对这些挑战。HCR、RCA、LAMP、CHA、SDA和CRISPR等分子策略都是依赖于miRNA生物传感器分子检测的方法。在这篇综述中，我们描述了用于检测mirna的分子生物传感器领域的最新进展，并讨论和比较了应用于分子生物传感器平台的不同策略的可行性和性能。此外，提出的生物传感器的适用性已被考虑比较他们的临床结果。

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引用次数: 0

Recent advances in fluorescent nanosensors for point-of-care detection of pesticides 用于农药即时检测的荧光纳米传感器的最新进展

IF 12 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry

Pub Date : 2025-12-22 DOI: 10.1016/j.trac.2025.118624

Hao Liu , Lingyuan Kong , Chenyue Kang , Boyang Hua , Zheng Li

Pesticides are vital for global food security but their extensive use causes environmental contamination and health risks. Conventional detection methods including chromatography are sensitive but laboratory-bound, costly, and slow, hindering on-site monitoring. Fluorescent nanosensors have emerged as a transformative alternative for point-of-care (POC) detection, yet their evolution from laboratory demonstrations to robust field-ready platforms presents a multifaceted engineering challenge. This review systematically charts this development pathway, critically examining the interplay between nanomaterial design, molecular recognition elements, and portable instrumentation mostly emerged in the recent decade (2016–2025). We first analyze detection strategies tailored to major pesticide classes, then delve into the receptor systems that provide specificity. A core focus is placed on the integration of these nanosensors into miniaturized platforms, such as smartphone-based devices and microfluidic chips, and the role of AI for data analysis in complex matrices. Finally, we address the key hurdles of matrix interference, sensor stability, and multiplexing, offering forward-looking perspectives on intelligent, self-calibrating systems. By framing the discussion through the lens of practical application, this review aims to bridge fundamental research with the pressing need for deployable pesticide monitoring solutions.

农药对全球粮食安全至关重要，但其广泛使用造成环境污染和健康风险。包括色谱法在内的传统检测方法灵敏度高，但受实验室限制，成本高，速度慢，妨碍了现场监测。荧光纳米传感器已经成为医疗现场（POC）检测的一种变革性替代方案，但它们从实验室演示到强大的现场就绪平台的演变带来了多方面的工程挑战。这篇综述系统地描绘了这一发展路径，批判性地研究了近十年（2016-2025）出现的纳米材料设计、分子识别元件和便携式仪器之间的相互作用。我们首先分析针对主要农药类别的检测策略，然后深入研究提供特异性的受体系统。核心焦点放在将这些纳米传感器集成到小型化平台上，例如基于智能手机的设备和微流控芯片，以及人工智能在复杂矩阵中数据分析的作用。最后，我们解决了矩阵干扰，传感器稳定性和多路复用的关键障碍，为智能自校准系统提供了前瞻性的观点。通过从实际应用的角度进行讨论，本综述旨在将基础研究与可部署的农药监测解决方案的迫切需求联系起来。

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引用次数: 0

Magnetic resonance imaging contrast agents: Applications in tumor diagnosis and treatment 磁共振成像造影剂：在肿瘤诊断和治疗中的应用

IF 12 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry

Pub Date : 2025-12-22 DOI: 10.1016/j.trac.2025.118617

Lidong Han , Chuanchen Wu , Zhanxiang He , Junyan Li , Pengfei Shi , Shusheng Zhang

With the increasing demand for Magnetic Resonance Imaging (MRI) contrast agents in clinical applications, we reviews the progress of research on various MRI contrast agents based on iron, manganese, gadolinium, as well as other metal ions and fluorine in the past decade. In this review, surface modification with targeting groups (e.g., antibody, peptide, aptamer) and functional molecules as well as the combination of therapeutic-functional nanomaterials (e.g., Au, quantum dot), have promoted the continuous development of new magnetic resonance imaging agents in tumor diagnosis and treatment. The relaxation rate of most MRI contrast agents are much higher than the commercial materials. Furthermore, the advantages and challenges of these MRI contrast agents for clinical application are prospected. The detailed description of MRI contrast agents in tumor diagnosis and therapy in this review is anticipated to attract extensive interest from researchers in fields of nanomedicine, elevating the precision and efficacy of tumor diagnosis.

随着磁共振成像（MRI）造影剂在临床应用中的需求不断增加，本文综述了近十年来以铁、锰、钆等金属离子和氟为基础的各种MRI造影剂的研究进展。本文综述了靶向基团（如抗体、肽、适体）和功能分子的表面修饰以及治疗功能纳米材料（如金、量子点）的结合，促进了新型磁共振显像剂在肿瘤诊断和治疗中的不断发展。大多数MRI造影剂的松弛率远高于市售材料。展望了这些MRI造影剂在临床应用中的优势和挑战。本文对MRI造影剂在肿瘤诊断和治疗中的详细描述，有望引起纳米医学领域研究人员的广泛兴趣，提高肿瘤诊断的准确性和有效性。

引用次数: 0

Gas–phase sampling and preconcentration of nerve agents: Overview of thermally desorbable materials used 神经毒剂的气相取样和预浓缩：所使用的热脱吸材料概述

IF 12 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry

Pub Date : 2025-12-22 DOI: 10.1016/j.trac.2025.118618

Michał Grabka, Klaudia Kozon, Krzysztof Jasek, Jerzy Choma

For gas-phase sampling of nerve agents, general-purpose sorbents with limited selectivity toward target compounds are typically used. However, materials designed to exploit the specific physicochemical properties of nerve agents have been increasingly reported in the literature. This review discusses and compares individual sorbents based on their physicochemical properties in relation to the characteristics of the target analytes, with particular emphasis on sorption selectivity. A concise overview of the applications of sorptive materials in the analysis of nerve agents and related substances is also provided. Particular attention is given to materials used in three major types of sampling systems, which, in our opinion, represent a comprehensive cross-section of the sorptive materials employed: thermal desorption sorbent tubes, headspace solid-phase microextraction fibres, and online preconcentrators for gas analysers. Finally, current challenges and future perspectives in developing novel materials are discussed, highlighting sorbents with significant potential for practical implementation.

对于神经毒剂的气相取样，通常使用对目标化合物选择性有限的通用吸附剂。然而，在文献中越来越多地报道了设计用于利用神经毒剂的特定物理化学性质的材料。这篇综述讨论和比较了基于其物理化学性质的吸附剂与目标分析物的特性，特别强调了吸附选择性。简要概述了吸附材料在神经毒剂及相关物质分析中的应用。特别注意在三种主要类型的采样系统中使用的材料，在我们看来，它们代表了所采用的吸附材料的全面横截面：热解吸吸附管，顶空固相微萃取纤维和气体分析仪的在线预浓缩器。最后，讨论了开发新材料的当前挑战和未来前景，重点介绍了具有实际应用潜力的吸附剂。

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引用次数: 0

Revealing the past: Sedimentary archives as historical records of ionizable organic contaminant trends 揭示过去：沉积档案作为电离有机污染物趋势的历史记录

IF 12 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry

Pub Date : 2025-12-20 DOI: 10.1016/j.trac.2025.118623

Thomas Thiebault

Sedimentary archives offer a valuable means to reconstruct historical trends of ionizable organic contaminants (IOCs) in aquatic environments. While research has traditionally emphasized hydrophobic pollutants, interest in IOCs, such as pharmaceuticals, pesticides, PFAS, and surfactants, has grown due to their pseudo-persistence and widespread use. This review explores how sediment records can reveal past contamination and regulatory impacts, despite challenges like complex sorption mechanisms, pH variability, and dating uncertainties. Although linking sediment concentrations to historical water quality remains challenging, temporal trends often align with market approvals, regulations, and treatment upgrades. Advances in non-target screening also enable retrospective identification of previously undetected compounds. Despite remaining uncertainties, sediment archives complement water monitoring and enhance understanding of long-term environmental change. Continued interdisciplinary research is essential to improve quantification methods and inform future pollution management and policy decisions.

沉积档案为重建水生环境中可电离有机污染物的历史趋势提供了一种有价值的手段。虽然研究传统上强调疏水性污染物，但由于其伪持久性和广泛使用，对IOCs（如药品、农药、PFAS和表面活性剂）的兴趣越来越大。这篇综述探讨了沉积物记录如何揭示过去的污染和监管影响，尽管存在复杂的吸附机制、pH变化和年代不确定性等挑战。尽管将沉积物浓度与历史水质联系起来仍然具有挑战性，但时间趋势通常与市场批准、法规和处理升级相一致。非靶标筛选的进步也使以前未检测到的化合物的回顾性鉴定成为可能。尽管仍存在不确定性，但沉积物档案补充了水监测并增强了对长期环境变化的理解。持续的跨学科研究对于改进量化方法和为未来的污染管理和政策决策提供信息至关重要。

引用次数: 0

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