Pub Date : 2025-02-01DOI: 10.1016/j.trac.2024.118101
Zeheng Lin, Joshua Abbott, Peter Karuso, Danny K.Y. Wong
This paper is an overview of developments over the 2010–2024 period in electroanalytical sensing techniques for the detection of volatile organic compounds (VOCs), providing new perspectives to enhance the real-world applications of these techniques. VOCs constitute the major odorants in nature and urban environments. Their efficient detection carries substantial societal implications from human health monitoring to biological management. Among various detection methods, electroanalytical sensing enables sensitive, selective, on-site VOC detection at room temperature, and is thus emerging as a promising technology for field deployment. This review initially introduces typical sensing cells and the fundamentals of electroanalytical techniques commonly employed in VOC detection, exemplifying their working principles, strengths, and limitations. The discussion then delves into examples of promising electroanalytical VOC sensing systems, focusing on their detection mechanisms and critical system components. Finally, opportunities and challenges towards field deployment of electroanalytical VOC sensing are presented, guiding development efforts for enhanced technology readiness levels.
{"title":"Advances in electroanalytical sensing of volatile organic compounds towards field-deployable detection","authors":"Zeheng Lin, Joshua Abbott, Peter Karuso, Danny K.Y. Wong","doi":"10.1016/j.trac.2024.118101","DOIUrl":"10.1016/j.trac.2024.118101","url":null,"abstract":"<div><div>This paper is an overview of developments over the 2010–2024 period in electroanalytical sensing techniques for the detection of volatile organic compounds (VOCs), providing new perspectives to enhance the real-world applications of these techniques. VOCs constitute the major odorants in nature and urban environments. Their efficient detection carries substantial societal implications from human health monitoring to biological management. Among various detection methods, electroanalytical sensing enables sensitive, selective, on-site VOC detection at room temperature, and is thus emerging as a promising technology for field deployment. This review initially introduces typical sensing cells and the fundamentals of electroanalytical techniques commonly employed in VOC detection, exemplifying their working principles, strengths, and limitations. The discussion then delves into examples of promising electroanalytical VOC sensing systems, focusing on their detection mechanisms and critical system components. Finally, opportunities and challenges towards field deployment of electroanalytical VOC sensing are presented, guiding development efforts for enhanced technology readiness levels.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"183 ","pages":"Article 118101"},"PeriodicalIF":11.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.trac.2024.118105
Július Gajdár , Sara Rodrigues Gaspar , M. Gabriela Almeida
Nitrite has become increasingly significant analyte in analytical chemistry, with its monitoring being essential in various industrial sectors, environmental studies, and healthcare applications. The importance of nitrite detection is evident in the growing number of research publications focused on this topic in recent years. This review specifically concentrates on the development and application of electrochemical sensors. Herein, we provide a comprehensive overview of the methodologies used for nitrite determination, including approaches based on nitrite reduction and oxidation, as well as the use of nitrite biosensors and potentiometric sensors. We attempt to highlight the progress and innovations made in this field since 2010, aiming to give readers a broad understanding of the current state of research and its future directions.
{"title":"Trends in nitrite detection: Recent advances in electrochemical sensor technologies","authors":"Július Gajdár , Sara Rodrigues Gaspar , M. Gabriela Almeida","doi":"10.1016/j.trac.2024.118105","DOIUrl":"10.1016/j.trac.2024.118105","url":null,"abstract":"<div><div>Nitrite has become increasingly significant analyte in analytical chemistry, with its monitoring being essential in various industrial sectors, environmental studies, and healthcare applications. The importance of nitrite detection is evident in the growing number of research publications focused on this topic in recent years. This review specifically concentrates on the development and application of electrochemical sensors. Herein, we provide a comprehensive overview of the methodologies used for nitrite determination, including approaches based on nitrite reduction and oxidation, as well as the use of nitrite biosensors and potentiometric sensors. We attempt to highlight the progress and innovations made in this field since 2010, aiming to give readers a broad understanding of the current state of research and its future directions.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"183 ","pages":"Article 118105"},"PeriodicalIF":11.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.trac.2024.118066
Zhiyang An, Xiaoling Zhang, Jing Jing
Protein folding integrity in live cells is maintained by the protein homeostasis network, which includes molecular chaperones and degradation pathways. Failures in protein folding are implicated in a variety of human disorders, often resulting in protein aggregation and loss of function. While studies using purified proteins ex vivo provide valuable insights, the behavior of these proteins in living cells is significantly more complex than in simplified models. Therefore, advanced biomedical imaging techniques are essential for real-time, dynamic, and in situ monitoring of these phenomena in the cellular environment, particularly through fluorescence-based methods. This review discusses the use of small-molecule fluorescent probes to detect protein misfolding and aggregation in both in vitro and in vivo settings. Additionally, it highlights emerging design strategies for novel probes based on excited-state behavior. The ongoing development of these tools is expected to enhance our understanding of protein homeostasis and stress. Ultimately, advances in this field may contribute to the elucidation of disease mechanisms and facilitate the discovery of new therapeutic strategies.
{"title":"Recent advances in fluorescent probes development for interrogating protein misfolding and aggregation","authors":"Zhiyang An, Xiaoling Zhang, Jing Jing","doi":"10.1016/j.trac.2024.118066","DOIUrl":"10.1016/j.trac.2024.118066","url":null,"abstract":"<div><div>Protein folding integrity in live cells is maintained by the protein homeostasis network, which includes molecular chaperones and degradation pathways. Failures in protein folding are implicated in a variety of human disorders, often resulting in protein aggregation and loss of function. While studies using purified proteins <em>ex vivo</em> provide valuable insights, the behavior of these proteins in living cells is significantly more complex than in simplified models. Therefore, advanced biomedical imaging techniques are essential for real-time, dynamic, and <em>in situ</em> monitoring of these phenomena in the cellular environment, particularly through fluorescence-based methods. This review discusses the use of small-molecule fluorescent probes to detect protein misfolding and aggregation in both <em>in vitro</em> and <em>in vivo</em> settings. Additionally, it highlights emerging design strategies for novel probes based on excited-state behavior. The ongoing development of these tools is expected to enhance our understanding of protein homeostasis and stress. Ultimately, advances in this field may contribute to the elucidation of disease mechanisms and facilitate the discovery of new therapeutic strategies.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"183 ","pages":"Article 118066"},"PeriodicalIF":11.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143104748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.trac.2024.118083
Yuan Wei , Lei Zheng , Ying Chen , Jianwei Jiao , Jin Jiao , Yuna Guo
Sialic acid, a nine-carbon monosaccharide at the termini of glycan chains, is intricately linked to tumor progression and disease, necessitating highly sensitive analytical methods for accurate disease monitoring. This review elucidates advancements in the analysis of sialic acid, emphasizing methodologies including electrochemistry, mass spectrometry, fluorescence, and Raman scattering. Special attention is devoted to fluorescence-based techniques for the analysis of sialic acid within living cells, covering global, cell-specific, region-specific, and protein-specific strategies. Notably, variations in sialic acid abundance are connected to critical biological processes like tissue homeostasis, cell migration, and immune responses. This review also examines the wide-ranging applications of sialic acid, particularly in modulating cellular behavior through both internal and external glycan editing techniques. By systematically summarizing strategies for sialic acid analysis and regulation, and highlighting its dual influence, this review serves as a valuable resource for researchers aiming to deepen their understanding in this field.
{"title":"Analyzing and modifying sialic acid at the glycan end: Systematic review of methods and functional outcomes","authors":"Yuan Wei , Lei Zheng , Ying Chen , Jianwei Jiao , Jin Jiao , Yuna Guo","doi":"10.1016/j.trac.2024.118083","DOIUrl":"10.1016/j.trac.2024.118083","url":null,"abstract":"<div><div>Sialic acid, a nine-carbon monosaccharide at the termini of glycan chains, is intricately linked to tumor progression and disease, necessitating highly sensitive analytical methods for accurate disease monitoring. This review elucidates advancements in the analysis of sialic acid, emphasizing methodologies including electrochemistry, mass spectrometry, fluorescence, and Raman scattering. Special attention is devoted to fluorescence-based techniques for the analysis of sialic acid within living cells, covering global, cell-specific, region-specific, and protein-specific strategies. Notably, variations in sialic acid abundance are connected to critical biological processes like tissue homeostasis, cell migration, and immune responses. This review also examines the wide-ranging applications of sialic acid, particularly in modulating cellular behavior through both internal and external glycan editing techniques. By systematically summarizing strategies for sialic acid analysis and regulation, and highlighting its dual influence, this review serves as a valuable resource for researchers aiming to deepen their understanding in this field.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"183 ","pages":"Article 118083"},"PeriodicalIF":11.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143104751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.trac.2024.118115
Jan Brodský , Ludovico Migliaccio , Ihor Sahalianov , Ondřej Zítka , Pavel Neužil , Imrich Gablech
The growing global demand for water quality monitoring, driven by industrialization and pollution, underscores the need for efficient detection systems. Poly(3,4-ethylenedioxythiophene) (PEDOT)-based electrochemical sensors have emerged as promising tools due to their high conductivity, stability, and biocompatibility. This review highlights recent advancements in PEDOT-based sensors for detecting water pollutants, including heavy metals and organic contaminants. It explores synthesis methods and functionalization techniques that enhance PEDOT's sensitivity and selectivity under diverse conditions, supporting real-time monitoring. Innovations such as combining PEDOT with nanomaterials and the Internet of Things have expanded its capabilities, enabling continuous, accurate assessments. However, challenges remain in improving PEDOT's stability, scalability, and selectivity in real-world environments. This review summarizes the current progress, addresses ongoing challenges, and discusses future directions, such as integrating PEDOT with metal-organic frameworks and composites, to develop reliable, high-performance environmental sensors.
{"title":"Advancements in PEDOT-based electrochemical sensors for water quality monitoring: From synthesis to applications","authors":"Jan Brodský , Ludovico Migliaccio , Ihor Sahalianov , Ondřej Zítka , Pavel Neužil , Imrich Gablech","doi":"10.1016/j.trac.2024.118115","DOIUrl":"10.1016/j.trac.2024.118115","url":null,"abstract":"<div><div>The growing global demand for water quality monitoring, driven by industrialization and pollution, underscores the need for efficient detection systems. Poly(3,4-ethylenedioxythiophene) (PEDOT)-based electrochemical sensors have emerged as promising tools due to their high conductivity, stability, and biocompatibility. This review highlights recent advancements in PEDOT-based sensors for detecting water pollutants, including heavy metals and organic contaminants. It explores synthesis methods and functionalization techniques that enhance PEDOT's sensitivity and selectivity under diverse conditions, supporting real-time monitoring. Innovations such as combining PEDOT with nanomaterials and the Internet of Things have expanded its capabilities, enabling continuous, accurate assessments. However, challenges remain in improving PEDOT's stability, scalability, and selectivity in real-world environments. This review summarizes the current progress, addresses ongoing challenges, and discusses future directions, such as integrating PEDOT with metal-organic frameworks and composites, to develop reliable, high-performance environmental sensors.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"183 ","pages":"Article 118115"},"PeriodicalIF":11.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143104753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.trac.2024.118112
Tao Dong , Nuno Miguel Matos Pires , Zhaochu Yang , José Higino Correia , Weixuan Jing , Qijing Lin , Libo Zhao , Yumei Wen , Zhuangde Jiang
Circular RNAs (circRNAs) have emerged as pivotal regulators in various biological processes and disease states, including cancer, neurodegenerative disorders, and cardiovascular diseases, making them promising biomarkers for early diagnosis and therapeutic monitoring. This review provides a comprehensive overview of traditional and emerging molecular assays and biosensors for circRNA detection, critically examining key challenges in their development and application. Conventional methods such as RT-PCR, Northern blot, and in situ hybridization remain prominent, while the emerging techniques include reverse transcription-based and non-reverse transcription-based assays, hybrid systems, and point-of-care biosensors. RT-RCA and RT-LAMP have shown potential as valuable alternatives to RT-PCR. In hybrid systems, where target recognition and amplification are performed using different assay approaches, RCA and LAMP are particularly promising for the amplification stage. Non-RT-based assays are gaining significant research attention due to their ability to avoid inaccuracies associated with reverse transcriptase use. Among these, CRISPR-Cas13 and duplex-specific nuclease (DSN)-based assays exhibit notably high sensitivity. Molecular assays using enzyme probe ligation techniques for target recognition provide superior detection accuracy, a feature comparable to nanoString technology. Additionally, microfluidics and nanomaterials have been employed to enhance the performance of circRNA point-of-care sensors. Despite these advances, practical circRNA detection methodologies still face challenges, such as long assay times, limited multiplexing capabilities, and complex circRNA enrichment procedures. This review addresses current technological hurdles and outlines future perspectives in circRNA analysis. Innovation in methodologies, along with the discovery and validation of new circRNA markers, can accelerate the translation of circRNA detection methods into clinical and biomedical applications.
{"title":"Advances in molecular assays and biosensors for circular RNA-based diagnostics and therapeutic monitoring","authors":"Tao Dong , Nuno Miguel Matos Pires , Zhaochu Yang , José Higino Correia , Weixuan Jing , Qijing Lin , Libo Zhao , Yumei Wen , Zhuangde Jiang","doi":"10.1016/j.trac.2024.118112","DOIUrl":"10.1016/j.trac.2024.118112","url":null,"abstract":"<div><div>Circular RNAs (circRNAs) have emerged as pivotal regulators in various biological processes and disease states, including cancer, neurodegenerative disorders, and cardiovascular diseases, making them promising biomarkers for early diagnosis and therapeutic monitoring. This review provides a comprehensive overview of traditional and emerging molecular assays and biosensors for circRNA detection, critically examining key challenges in their development and application. Conventional methods such as RT-PCR, Northern blot, and <em>in situ</em> hybridization remain prominent, while the emerging techniques include reverse transcription-based and non-reverse transcription-based assays, hybrid systems, and point-of-care biosensors. RT-RCA and RT-LAMP have shown potential as valuable alternatives to RT-PCR. In hybrid systems, where target recognition and amplification are performed using different assay approaches, RCA and LAMP are particularly promising for the amplification stage. Non-RT-based assays are gaining significant research attention due to their ability to avoid inaccuracies associated with reverse transcriptase use. Among these, CRISPR-Cas13 and duplex-specific nuclease (DSN)-based assays exhibit notably high sensitivity. Molecular assays using enzyme probe ligation techniques for target recognition provide superior detection accuracy, a feature comparable to nanoString technology. Additionally, microfluidics and nanomaterials have been employed to enhance the performance of circRNA point-of-care sensors. Despite these advances, practical circRNA detection methodologies still face challenges, such as long assay times, limited multiplexing capabilities, and complex circRNA enrichment procedures. This review addresses current technological hurdles and outlines future perspectives in circRNA analysis. Innovation in methodologies, along with the discovery and validation of new circRNA markers, can accelerate the translation of circRNA detection methods into clinical and biomedical applications.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"183 ","pages":"Article 118112"},"PeriodicalIF":11.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143104756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.trac.2024.118095
Yuewei Wang , Jie Wang , Xiaofeng Cao , Weixiao Qi , Jianfeng Peng , Huijuan Liu , Jiuhui Qu
Tire wear particles (TWPs) are underappreciated microplastics. However, their presence in aquatic ecosystems has not received equal attention as that in the atmosphere and soil, which hinders TWP pollution recognition and mitigation efforts. Acknowledging their unique hazards, this review summarizes the current knowledge on TWP occurrence, behaviors, biological effects, and remediation technologies in aquatic ecosystems. TWPs have been found in waters worldwide; but their transport and distribution can not be fully assessed due to the lack of standardized analytical methods. In vivo bioassays and field investigations have indicated TWPs’ toxicity on aquatic organisms at various trophic levels. Based on environmental behaviors of TWPs, promising remediation technologies with an emphasis on source reduction, interception, and end-of-pipe treatment are proposed. Finally, this review highlights the limitations of current knowledge and provides a timely guidance for future research on TWP analysis, toxicity assessment and pollution mitigation.
{"title":"Tire wear particles in aquatic ecosystems: Current knowledge and future perspectives","authors":"Yuewei Wang , Jie Wang , Xiaofeng Cao , Weixiao Qi , Jianfeng Peng , Huijuan Liu , Jiuhui Qu","doi":"10.1016/j.trac.2024.118095","DOIUrl":"10.1016/j.trac.2024.118095","url":null,"abstract":"<div><div>Tire wear particles (TWPs) are underappreciated microplastics. However, their presence in aquatic ecosystems has not received equal attention as that in the atmosphere and soil, which hinders TWP pollution recognition and mitigation efforts. Acknowledging their unique hazards, this review summarizes the current knowledge on TWP occurrence, behaviors, biological effects, and remediation technologies in aquatic ecosystems. TWPs have been found in waters worldwide; but their transport and distribution can not be fully assessed due to the lack of standardized analytical methods. <em>In vivo</em> bioassays and field investigations have indicated TWPs’ toxicity on aquatic organisms at various trophic levels. Based on environmental behaviors of TWPs, promising remediation technologies with an emphasis on source reduction, interception, and end-of-pipe treatment are proposed. Finally, this review highlights the limitations of current knowledge and provides a timely guidance for future research on TWP analysis, toxicity assessment and pollution mitigation.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"183 ","pages":"Article 118095"},"PeriodicalIF":11.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.trac.2024.118107
Long Chen , Luana Bontempo
Herbs have been consumed for their health benefits for centuries and are still attracting increasingly more attention. Their quality is prone to changes in climatic and geo−chemical conditions. Local cultivation patterns also impact the quality of herbs. Therefore, geographical origin is often regarded as an indicator of quality. However, profit−motivated fraud and adulterations degraded the quality of relevant products, and also destroyed the consumers’ health and trust. Isotope ratio mass spectrometry (IRMS) is particularly useful in verifying the origin of herbs as the isotopic composition of several light elements (C, H, O, N and S) contain information about the geographical locations. Changes in the isotopic composition cannot be identified by other techniques but may be detected using IRMS. In this review, current applications of IRMS in tracing ginseng, saffron, chrysanthemum flos and goji berries were discussed and future development was envisaged.
{"title":"Application of isotope ratio mass spectrometry (IRMS) in the geographical determination of selected herbs: A review","authors":"Long Chen , Luana Bontempo","doi":"10.1016/j.trac.2024.118107","DOIUrl":"10.1016/j.trac.2024.118107","url":null,"abstract":"<div><div>Herbs have been consumed for their health benefits for centuries and are still attracting increasingly more attention. Their quality is prone to changes in climatic and geo−chemical conditions. Local cultivation patterns also impact the quality of herbs. Therefore, geographical origin is often regarded as an indicator of quality. However, profit−motivated fraud and adulterations degraded the quality of relevant products, and also destroyed the consumers’ health and trust. Isotope ratio mass spectrometry (IRMS) is particularly useful in verifying the origin of herbs as the isotopic composition of several light elements (C, H, O, N and S) contain information about the geographical locations. Changes in the isotopic composition cannot be identified by other techniques but may be detected using IRMS. In this review, current applications of IRMS in tracing ginseng, saffron, chrysanthemum flos and goji berries were discussed and future development was envisaged.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"183 ","pages":"Article 118107"},"PeriodicalIF":11.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.trac.2024.118113
Asmaa Kamal El-Deen , Chaudhery Mustansar Hussain
The global emphasis on green nanotechnology has resulted in the ecological and physiological safe uses of nanomaterials. Several works have been performed on the biological, chemical, and physical production of metal nanoparticles. The safety and ease of synthesis of biological techniques make them the best choice. Gold nanoparticles (AuNPs) are powerful, biodegradable, and ecologically friendly nanoparticles that have recently acquired popularity. This study highlights the current state of the art in this subject, with an emphasis on the synthesis, characterization, and applications of bio-based AuNPs. It emphasizes their usage in forensic science, air pollution monitoring, and environmental sample analysis. The challenges and restrictions of this growing discipline are discussed, as well as its future prospects. Finally, this review highlights the enormous potential of bio-based AuNPs as a sustainable solution for environmental and forensic applications, paving the path for a greener, more ecologically friendly future.
{"title":"Bio-based gold nanoparticles for environmental and forensic samples: State of the art with a sustainable way forward","authors":"Asmaa Kamal El-Deen , Chaudhery Mustansar Hussain","doi":"10.1016/j.trac.2024.118113","DOIUrl":"10.1016/j.trac.2024.118113","url":null,"abstract":"<div><div>The global emphasis on green nanotechnology has resulted in the ecological and physiological safe uses of nanomaterials. Several works have been performed on the biological, chemical, and physical production of metal nanoparticles. The safety and ease of synthesis of biological techniques make them the best choice. Gold nanoparticles (AuNPs) are powerful, biodegradable, and ecologically friendly nanoparticles that have recently acquired popularity. This study highlights the current state of the art in this subject, with an emphasis on the synthesis, characterization, and applications of bio-based AuNPs. It emphasizes their usage in forensic science, air pollution monitoring, and environmental sample analysis. The challenges and restrictions of this growing discipline are discussed, as well as its future prospects. Finally, this review highlights the enormous potential of bio-based AuNPs as a sustainable solution for environmental and forensic applications, paving the path for a greener, more ecologically friendly future.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"183 ","pages":"Article 118113"},"PeriodicalIF":11.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.trac.2024.118102
Yingxue Jin , Jingjing Yan , Zongwei Cai , Zian Lin
Surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) has been regarded as one of the prominent techniques in small molecule analysis, which employs nanostructured materials as substrates to replace conventional organic matrices for laser absorption and analyte desorption/ionization. The rational design and development of nanostructured substrates, particularly metal-organic frameworks (MOFs) and covalent-organic frameworks (COFs), are crucial for enhancing SALDI-MS performance. This review aims to cover the latest developments (within 5 years) in nanostructured substrates in SALDI-MS, including carbon- and silicon-based materials, metals and their oxide materials, MOFs, COFs, and other materials. The key design parameters that affect the SALDI-MS efficiency of these nanomaterials in small molecule analysis, such as pore size, surface area, and functional groups, are also discussed. Furthermore, the applications of SALDI-MS in various fields are reviewed. Lastly, the challenges and prospects for future research on the design of nanostructured substrates for SALDI-MS in small molecule analysis are discussed.
{"title":"Advances in nanomaterials for surface-assisted laser desorption ionization mass spectrometry: Applications in small molecule analysis over the past five years","authors":"Yingxue Jin , Jingjing Yan , Zongwei Cai , Zian Lin","doi":"10.1016/j.trac.2024.118102","DOIUrl":"10.1016/j.trac.2024.118102","url":null,"abstract":"<div><div>Surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) has been regarded as one of the prominent techniques in small molecule analysis, which employs nanostructured materials as substrates to replace conventional organic matrices for laser absorption and analyte desorption/ionization. The rational design and development of nanostructured substrates, particularly metal-organic frameworks (MOFs) and covalent-organic frameworks (COFs), are crucial for enhancing SALDI-MS performance. This review aims to cover the latest developments (within 5 years) in nanostructured substrates in SALDI-MS, including carbon- and silicon-based materials, metals and their oxide materials, MOFs, COFs, and other materials. The key design parameters that affect the SALDI-MS efficiency of these nanomaterials in small molecule analysis, such as pore size, surface area, and functional groups, are also discussed. Furthermore, the applications of SALDI-MS in various fields are reviewed. Lastly, the challenges and prospects for future research on the design of nanostructured substrates for SALDI-MS in small molecule analysis are discussed.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"183 ","pages":"Article 118102"},"PeriodicalIF":11.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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