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IF 11.6 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Trends in Biochemical Sciences
Pub Date : 2025-07-01 DOI: 10.1016/S0968-0004(25)00146-X
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引用次数: 0
Advisory Board and Contents 咨询委员会及内容
IF 11.6 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Trends in Biochemical Sciences
Pub Date : 2025-07-01 DOI: 10.1016/S0968-0004(25)00143-4
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引用次数: 0
Diverse lineages and adaptations of oxygen-adapted hydrogenases 适应氧的氢化酶的不同谱系和适应性。
IF 11.6 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Trends in Biochemical Sciences
Pub Date : 2025-07-01 DOI: 10.1016/j.tibs.2025.04.006
Marion Jespersen , Chris Greening , Leonard Ernst , Pok Man Leung , Hannah S. Shafaat , Rhys Grinter
Hydrogenases allow microorganisms to consume and produce hydrogen gas (H2). Although most hydrogenases are oxygen (O2)-sensitive, recent studies show that bacteria and archaea produce diverse nickel–iron [NiFe]-hydrogenases that function in oxic environments and often support aerobic respiration. As we describe herein, these hydrogenases have independently evolved multiple strategies to withstand O2, not only by reversing inhibition through reduction of bound O2 to water using a unique [4Fe3S] cluster but also by preventing O2 binding through narrow gas channels and active-site rearrangements. We further propose that [NiFe]-hydrogenases originated on an anoxic Earth, but diversified after the Great Oxygenation Event to tolerate and exploit redox coupling with O2. Hydrogenases may be more adaptable to O2 than was previously thought, and this has implications for synthetic biology and biomimetics.
氢化酶允许微生物消耗和产生氢气（H2）。虽然大多数氢化酶对氧（O2）敏感，但最近的研究表明，细菌和古细菌产生多种镍铁[NiFe]氢化酶，这些酶在氧环境中起作用，通常支持有氧呼吸。正如我们在本文中所描述的，这些氢化酶已经独立地进化出多种抵抗O2的策略，不仅通过使用独特的[4Fe3S]簇将结合的O2还原为水来逆转抑制，而且通过狭窄的气体通道和活性位点重排来阻止O2结合。我们进一步提出，[NiFe]-氢化酶起源于缺氧的地球，但在大氧化事件后发生了多样化，以耐受和利用与O2的氧化还原偶联。氢化酶可能比以前认为的更能适应O2，这对合成生物学和仿生学有影响。
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引用次数: 0
Mitochondrial heat production: the elephant in the lab… 线粒体产热：实验室里的大象....
IF 11.6 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Trends in Biochemical Sciences
Pub Date : 2025-07-01 DOI: 10.1016/j.tibs.2025.03.002
Pierre Rustin , Howard T. Jacobs , Mügen Terzioglu , Paule Bénit
It has long been established that heat represents a major part of the energy released during the oxidation of mitochondrial substrates. However, with a few exceptions, the release of heat is rarely mentioned other than as being produced at the expense of ATP, without having any specific function. Here, after briefly surveying the literature on mitochondrial heat production, we argue for its cellular and organismal importance, sharing our opinions as to what could account for this unbalanced portrayal of mitochondrial energy transactions.
热是线粒体底物氧化过程中释放的能量的主要部分，这一点早已得到证实。然而，除了少数例外，热量的释放很少被提及，而是以ATP为代价产生的，没有任何特定的功能。在这里，简要调查了关于线粒体产热的文献后，我们认为其细胞和有机体的重要性，分享我们的观点，什么可以解释线粒体能量交易的这种不平衡的描述。
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引用次数: 0
Emerging mechanisms of human mitochondrial translation regulation 人类线粒体翻译调控的新机制。
IF 11.6 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Trends in Biochemical Sciences
Pub Date : 2025-07-01 DOI: 10.1016/j.tibs.2025.03.007
Michele Brischigliaro , Ahram Ahn , Seungwoo Hong , Flavia Fontanesi , Antoni Barrientos
Mitochondrial translation regulation enables precise control over the synthesis of hydrophobic proteins encoded by the organellar genome, orchestrating their membrane insertion, accumulation, and assembly into oxidative phosphorylation (OXPHOS) complexes. Recent research highlights regulation across all translation stages (initiation, elongation, termination, and recycling) through a complex interplay of mRNA structures, specialized translation factors, and unique regulatory mechanisms that adjust protein levels for stoichiometric assembly. Key discoveries include mRNA-programmed ribosomal pausing, frameshifting, and termination-dependent re-initiation, which fine-tune protein synthesis and promote translation of overlapping open reading frames (ORFs) in bicistronic transcripts. In this review, we examine these advances, which are significantly enhancing our understanding of mitochondrial gene expression.
线粒体翻译调节能够精确控制由细胞器基因组编码的疏水蛋白的合成，协调它们的膜插入，积累和组装成氧化磷酸化（OXPHOS）复合物。最近的研究强调了所有翻译阶段（起始、延伸、终止和再循环）的调节，通过mRNA结构、专门的翻译因子和调节化学计量组装蛋白质水平的独特调节机制的复杂相互作用。主要发现包括mrna程序性核糖体暂停、帧移和终止依赖性重新起始，它们可以微调蛋白质合成并促进双转录本中重叠开放阅读框（orf）的翻译。在这篇综述中，我们研究了这些进展，这些进展大大提高了我们对线粒体基因表达的理解。
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引用次数: 0
Sensitivity to chirality correlates in a continuum with protein disorder 对手性的敏感性与蛋白质紊乱连续相关。
IF 11.6 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Trends in Biochemical Sciences
Pub Date : 2025-07-01 DOI: 10.1016/j.tibs.2025.04.003
Lucía Álvarez , Lucía Beatriz Chemes
Intrinsically disordered proteins (IDPs) exist as dynamic conformational ensembles the behavior of which challenges the tenets of the protein structure–function paradigm. In a new study, Newcombe, Due et al. reveal a striking continuum in sensitivity to chirality: while folded complexes are under strong chiral constraints, progressively disordered complexes show decreased sensitivity to chirality.
内在无序蛋白（IDPs）以动态构象集合体的形式存在，其行为挑战了蛋白质结构-功能范式的原则。在一项新的研究中，Newcombe、Due等人揭示了对手性敏感性的惊人连续性：虽然折叠的配合物受到很强的手性约束，但逐渐无序的配合物对手性的敏感性下降。
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引用次数: 0
Discussing the future of mitochondrial biochemistry 讨论线粒体生物化学的未来。
IF 11.6 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Trends in Biochemical Sciences
Pub Date : 2025-07-01 DOI: 10.1016/j.tibs.2025.05.010
Antoni Barrientos , Flavia Fontanesi , Pierre Rustin , Agnieszka Chacinska
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引用次数: 0
Understanding mitochondrial protein import: a revised model of the presequence translocase 理解线粒体蛋白的输入：一个修正的前序转位酶模型。
IF 11.6 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Trends in Biochemical Sciences
Pub Date : 2025-07-01 DOI: 10.1016/j.tibs.2025.03.001
Naintara Jain , Agnieszka Chacinska , Peter Rehling
Mitochondrial function relies on the precise targeting and import of cytosolic proteins into mitochondrial subcompartments. Most matrix-targeted proteins follow the presequence pathway, which directs precursor proteins across the outer mitochondrial membrane (OMM) via the Translocase of the Outer Membrane (TOM) complex and into the matrix or inner mitochondrial membrane (IMM) via the Translocase of the Inner Membrane 23 (TIM23) complex. While classical biochemical studies provided detailed mechanistic insights into the composition and mechanism of the TIM23 complex, recent cryogenic-electron microscopy (cryo-EM) data challenge these established models and propose a revised model of translocation in which the TIM17 subunit acts as a ‘slide’ for precursor proteins, with Tim23 acting as a structural element. In this review, we summarize existing models, highlighting the questions and data needed to reconcile these perspectives, and enhance our understanding of TIM23 complex function.
线粒体功能依赖于细胞质蛋白进入线粒体亚室的精确靶向和进口。大多数基质靶向蛋白遵循前序途径，该途径引导前体蛋白通过外膜转位酶（TOM）复合物穿过线粒体外膜（OMM），并通过内膜转位酶23 （TIM23）复合物进入基质或线粒体内膜（IMM）。虽然经典的生化研究为TIM23复合物的组成和机制提供了详细的机制见解，但最近的低温电子显微镜（cryo-EM）数据挑战了这些已建立的模型，并提出了一种修正的易位模型，其中TIM17亚基作为前体蛋白的“载片”，TIM23作为结构元件。在这篇综述中，我们总结了现有的模型，强调了调和这些观点所需的问题和数据，并加强了我们对TIM23复合物功能的理解。
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引用次数: 0
Accelerating the stride toward functional glycoproteomics 加速向功能性糖蛋白组学迈进。
IF 11.6 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Trends in Biochemical Sciences
Pub Date : 2025-07-01 DOI: 10.1016/j.tibs.2025.04.002
Tim S. Veth , Nicholas M. Riley
The heterogeneity of the glycoproteome and the challenges associated with quantifying its regulation in complex biological systems have hindered functional glycoproteomics. The deep quantitative glycoprofiling (DQGlyco) method recently developed by Potel, Burtscher, and Garrido-Rodriguez et al. significantly improves the glycoproteomic depth compared with existing methods, aiding our ability to interrogate the functional implications of glycoproteins.
糖蛋白组的异质性以及在复杂生物系统中量化其调控的挑战阻碍了功能糖蛋白组学的发展。与现有方法相比，Potel、Burtscher和Garrido-Rodriguez等人最近开发的深度定量糖谱分析（DQGlyco）方法显著提高了糖蛋白组学深度，有助于我们探究糖蛋白的功能含义。
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引用次数: 0
Lipids: emerging actors in mitochondrial protein import 脂质：线粒体蛋白输入中的新角色。
IF 11.6 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Trends in Biochemical Sciences
Pub Date : 2025-07-01 DOI: 10.1016/j.tibs.2025.03.011
Mayra A. Borrero-Landazabal , Vanessa Linke , Agnieszka Chacinska
Lipids are emerging as functional players in mitochondrial protein import beyond constituting membranes. Cryo–electron microscopy structures of protein translocases such as translocase of the outer membrane (TOM) and insertases such as translocase of the inner membrane (TIM22) link lipids to protein import by suggesting structural and functional roles for lipids in protein translocation and insertion, and for protein insertases in lipid scrambling.
脂质正在成为线粒体蛋白进口的功能参与者，而不是构成膜。蛋白质转位酶（如外膜转位酶（TOM））和插入酶（如内膜转位酶（TIM22））的低温电子显微镜结构将脂质与蛋白质进口联系起来，表明脂质在蛋白质易位和插入中的结构和功能作用，以及蛋白质插入酶在脂质混乱中的作用。
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引用次数: 0
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