Abstract: This ethnographical qualitative study focused on health perceptions and practices of rural Guatemalan women. Researchers gathered data through interviews and observations in health, school, and village settings. Three themes emerged in data analysis: health practices are related to the situation of poverty; knowledge gaps exist related to healthcare; and natural remedies are a prevalent practice in rural communities. The findings can help structure sustainable health programs not only for rural Guatemalan communities but where poverty and/or lack of knowledge influence health, as well as point to the importance of nurses practicing cultural humility and providing collaborative care.