S. Ashwin, P. Sinduja, Selvaraj Jayaraman, R. Priyadharshini
Free radicals define oxidative stress as the condition in which the body's antioxidant repair systems cannot keep up with the rate of cell oxidation. Oxidative stress and reactive oxygen species (free radicals) work together to damage cellular components, encourage cell neoplastic transformation, and actively affect all three stages of carcinogenesis. The most prevalent potentially cancerous conditions on the Indian subcontinent are leukoplakia and oral submucous fibrosis, which are mostly brought on by cigarette use and areca nut consumption. Assessment of 8-OHDG, SOD, and GPx levels in saliva of OPMD and OSCC patients with and without diabetes mellitus. ELISA ASSAY was used for finding the levels of 8-OHDG, SOD, and GPx. Add salivary samples and diluent 40 μL into the testing sample. Then add some 10 μL sample into the testing sample well, Cover it properly, and incubate for some 45 minutes at 37 °C. Aspirate each well and wash, repeat the process four times for a total of five washes, 1-3 minutes per time. HRP-conjugated detection antibody is added to each well. This study is one of the first attempts to find the Assessment of 8-OHDG, SOD, and GPx levels in the saliva of OPMD and OSCC patients with and without diabetes mellitus.
{"title":"Assessment of 8-OHDG, SOD, and GPx Levels in OPMD and OSCC Patients","authors":"S. Ashwin, P. Sinduja, Selvaraj Jayaraman, R. Priyadharshini","doi":"10.51847/gxbko0irbp","DOIUrl":"https://doi.org/10.51847/gxbko0irbp","url":null,"abstract":"Free radicals define oxidative stress as the condition in which the body's antioxidant repair systems cannot keep up with the rate of cell oxidation. Oxidative stress and reactive oxygen species (free radicals) work together to damage cellular components, encourage cell neoplastic transformation, and actively affect all three stages of carcinogenesis. The most prevalent potentially cancerous conditions on the Indian subcontinent are leukoplakia and oral submucous fibrosis, which are mostly brought on by cigarette use and areca nut consumption. Assessment of 8-OHDG, SOD, and GPx levels in saliva of OPMD and OSCC patients with and without diabetes mellitus. ELISA ASSAY was used for finding the levels of 8-OHDG, SOD, and GPx. Add salivary samples and diluent 40 μL into the testing sample. Then add some 10 μL sample into the testing sample well, Cover it properly, and incubate for some 45 minutes at 37 °C. Aspirate each well and wash, repeat the process four times for a total of five washes, 1-3 minutes per time. HRP-conjugated detection antibody is added to each well. This study is one of the first attempts to find the Assessment of 8-OHDG, SOD, and GPx levels in the saliva of OPMD and OSCC patients with and without diabetes mellitus.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":"1 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70821858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The primary aim of this study is to compare the acute toxicity profiles between locally advanced rectal cancer (LARC) patients treated with preoperative 3-dimensional conformal radiotherapy (3D-CRT) and simultaneous integrated intensity modulated radiation therapy (SIB-IMRT). 40 patients with LARC were equally divided into 2 groups; arm A received preoperative 3D-CRT concurrent with Capecitabine, while arm B received preoperative SIB-IMRT concurrent with Capecitabine. All patients were seen and evaluated once a week during chemo-radiation and any acute toxicity was recorded. Significantly fewer patients experienced grade 3 genitourinary toxicities in arm B vs arm A with a p-value = 0.048. Regarding grade 2 and grade 3 gastrointestinal toxicities, it was significantly higher in arm A compared to arm B with p-values of 0.043 and 0.021 respectively. There were no statically significant differences between Dmean & Dmax of the urinary bladder (UB) and small bowel (SB) in both techniques. The V45 of the UB was higher significantly in the 3D-CRT plans compared to the SIB-IMRT plans, with a p-value of 0.003. The V45 of SB was higher in the 3D-CRT arm with a p-value of 0.001. The V45 of UB & SB was statistically less in the IMRT plans compared to the 3DCRT plans. This was reflected in the toxicity profile of the patients, grade 2 GU as well as grades 2 & 3 GI toxicities were statistically of lower frequency in the IMRT group compared to the 3DCRT group.
{"title":"3D-CRT Versus SIB IMRT Acute Toxicity Outcomes in Preoperative Concurrent Chemo-Radiotherapy for Locally Advanced Rectal Cancer","authors":"K. Mashhour, E. Saad, Hoda Abdelghany, W. Hashem","doi":"10.51847/uban5n4ccd","DOIUrl":"https://doi.org/10.51847/uban5n4ccd","url":null,"abstract":"The primary aim of this study is to compare the acute toxicity profiles between locally advanced rectal cancer (LARC) patients treated with preoperative 3-dimensional conformal radiotherapy (3D-CRT) and simultaneous integrated intensity modulated radiation therapy (SIB-IMRT). 40 patients with LARC were equally divided into 2 groups; arm A received preoperative 3D-CRT concurrent with Capecitabine, while arm B received preoperative SIB-IMRT concurrent with Capecitabine. All patients were seen and evaluated once a week during chemo-radiation and any acute toxicity was recorded. Significantly fewer patients experienced grade 3 genitourinary toxicities in arm B vs arm A with a p-value = 0.048. Regarding grade 2 and grade 3 gastrointestinal toxicities, it was significantly higher in arm A compared to arm B with p-values of 0.043 and 0.021 respectively. There were no statically significant differences between Dmean & Dmax of the urinary bladder (UB) and small bowel (SB) in both techniques. The V45 of the UB was higher significantly in the 3D-CRT plans compared to the SIB-IMRT plans, with a p-value of 0.003. The V45 of SB was higher in the 3D-CRT arm with a p-value of 0.001. The V45 of UB & SB was statistically less in the IMRT plans compared to the 3DCRT plans. This was reflected in the toxicity profile of the patients, grade 2 GU as well as grades 2 & 3 GI toxicities were statistically of lower frequency in the IMRT group compared to the 3DCRT group.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":"1 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70835970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Muhammed Huzaifa, Ankita Singh, Vaibhav Aggarwal, A. Dhar
Adenocarcinoma at the colostomy site rarely occurs after abdominopelvic resection (APR), only a handful of cases are reported in the literature. In absence of biopsy such growth may masquerade as hyperplasia or granulation tissue at stomal edges, leading to diagnostic dilemmas. We report an unusual case of a gentleman in his late 50s who underwent abdominoperineal resection for rectal cancer following which he presented with stomal site growth without distant metastasis 12 years later. In view of the absence of distant metastasis, segmental colonic resection with 2 cm skin margin and revision colostomy was performed with a plan of adjuvant therapy thereafter. Though carcinoma at the colostomy site is uncommon, careful stomal observation and examination for surveillance should be done during each follow-up and we suggest early biopsy and colonoscopy in case of suspicion. Segmental colonic resection with skin margin and adjuvant therapy is the preferred option in such presentations.
{"title":"Metachronous Carcinoma at Colostomy Site Post Abdominoperineal Resection – A Rare Presentation Case Report","authors":"Muhammed Huzaifa, Ankita Singh, Vaibhav Aggarwal, A. Dhar","doi":"10.51847/zp8hs1y926","DOIUrl":"https://doi.org/10.51847/zp8hs1y926","url":null,"abstract":"Adenocarcinoma at the colostomy site rarely occurs after abdominopelvic resection (APR), only a handful of cases are reported in the literature. In absence of biopsy such growth may masquerade as hyperplasia or granulation tissue at stomal edges, leading to diagnostic dilemmas. We report an unusual case of a gentleman in his late 50s who underwent abdominoperineal resection for rectal cancer following which he presented with stomal site growth without distant metastasis 12 years later. In view of the absence of distant metastasis, segmental colonic resection with 2 cm skin margin and revision colostomy was performed with a plan of adjuvant therapy thereafter. Though carcinoma at the colostomy site is uncommon, careful stomal observation and examination for surveillance should be done during each follow-up and we suggest early biopsy and colonoscopy in case of suspicion. Segmental colonic resection with skin margin and adjuvant therapy is the preferred option in such presentations.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":"1 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70843591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Adenoid Cystic Carcinoma of the Breast: A Case Report","authors":"T. H. Alhussan, Ahmad Hadad, S. Shah","doi":"10.51847/c9m7tisulk","DOIUrl":"https://doi.org/10.51847/c9m7tisulk","url":null,"abstract":"","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":"1 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70817236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Saad, M. Kamaleldin, Asmaa Zaghloul, E. Habib, K. Mashhour
In fast-growing tumors such as locally advanced head and neck cancers (LA-HNC), hypofractionation effectively overcomes tumor repopulation. We aimed at evaluating the safety and efficacy of moderately hypofractionated radiotherapy with concurrent cisplatin in comparison to the conventional concurrent chemoradiotherapy (CCRT) in LA-HNC. Fifty-four patients with LA-HNC were randomized to receive either: 70Gy in 35 fractions in 7 weeks concurrently with weekly cisplatin 40 mg/m2 (Arm A), or 55Gy in 20 fractions in 4 weeks concurrently with weekly cisplatin 35mg/m2 (Arm B). Volumetric modulated arc therapy/ Intensity-modulated radiotherapy (VMAT/IMRT) plans were done for both arms. Local control (LC), acute toxicity, and progression-free survival (PFS) were recorded and compared between both arms. A total of 34 patients were in arm A versus 20 patients in arm B, with a median follow-up period of 14.2 months (range 5.1-43.6 months). There was no significant difference in LC, PFS, or acute toxicity between both arms. Complete response occurred in 52.9%(18/34) and 45 %(9/20) in arm A and arm B respectively. In LA-HNC, moderate hypofractionation concurrently with cisplatin appears to be safe and feasible and is associated with a comparable response rate, PFS, and acute toxicity with conventional CCRT protocol.
{"title":"Hypofractionated Accelerated Radiotherapy with Concurrent Chemotherapy Versus Conventional Fractionation for LAHNSCC Using IMRT/VMAT: A Pilot Study","authors":"E. Saad, M. Kamaleldin, Asmaa Zaghloul, E. Habib, K. Mashhour","doi":"10.51847/vpfpxwghhc","DOIUrl":"https://doi.org/10.51847/vpfpxwghhc","url":null,"abstract":"In fast-growing tumors such as locally advanced head and neck cancers (LA-HNC), hypofractionation effectively overcomes tumor repopulation. We aimed at evaluating the safety and efficacy of moderately hypofractionated radiotherapy with concurrent cisplatin in comparison to the conventional concurrent chemoradiotherapy (CCRT) in LA-HNC. Fifty-four patients with LA-HNC were randomized to receive either: 70Gy in 35 fractions in 7 weeks concurrently with weekly cisplatin 40 mg/m2 (Arm A), or 55Gy in 20 fractions in 4 weeks concurrently with weekly cisplatin 35mg/m2 (Arm B). Volumetric modulated arc therapy/ Intensity-modulated radiotherapy (VMAT/IMRT) plans were done for both arms. Local control (LC), acute toxicity, and progression-free survival (PFS) were recorded and compared between both arms. A total of 34 patients were in arm A versus 20 patients in arm B, with a median follow-up period of 14.2 months (range 5.1-43.6 months). There was no significant difference in LC, PFS, or acute toxicity between both arms. Complete response occurred in 52.9%(18/34) and 45 %(9/20) in arm A and arm B respectively. In LA-HNC, moderate hypofractionation concurrently with cisplatin appears to be safe and feasible and is associated with a comparable response rate, PFS, and acute toxicity with conventional CCRT protocol.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":"132 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70837383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Preethi Raj, R Priyadharshini, Selvaraj Jayaraman, Palati Sinduja
The burden of cancer incidence and mortality is rapidly increasing worldwide. The second most frequent cancer in men is prostate cancer which affects 1.41 million people worldwide (WHO statistics). Stevioside is an easily available item and it was observed to significantly inhibit cancer cell growth. Our study aims to analyze Molecular mechanisms underlying the chemopreventive anticancer activity of Stevioside on human prostate cancer cell lines. Prostate cancer cells were treated with Stevioside and the level of Bcl-2, Mcl-1, and Caspase-3 was estimated respectively. Data were expressed as the mean ± SD of 3 individual experiments performed in triplicate. Statistical analysis was performed using one-way ANOVA. In PC-3 cells, the effect of Stevioside extracts on cell viability was analyzed through MTT assay with a significant decrease in the percentage of viable cells with an increase in concentration, while the Mcl-1 gene with a decrease in fold change with a rise in concentration. Caspase 3 with a significant increase in fold change with an increase in concentration indicates effective apoptosis and also inhibits the Bcl-2 gene with a decrease in fold change with a rise in concentration with a significance of p<0.05. According to the results Stevioside extract considerably and strongly (by a significant fold change) suppresses the proliferation of cancer cells. The results imply that Stevioside may be turned into a natural prostate cancer medication and further investigation is necessary to establish the daily intake of Stevia products that is both safe and beneficial to the health of the human body.
{"title":"Molecular Mechanisms Underlying Chemopreventive Anticancer Activity of Stevioside on Human Prostate Cancer Cell Line in vitro","authors":"Preethi Raj, R Priyadharshini, Selvaraj Jayaraman, Palati Sinduja","doi":"10.51847/lvxdmvxrty","DOIUrl":"https://doi.org/10.51847/lvxdmvxrty","url":null,"abstract":"The burden of cancer incidence and mortality is rapidly increasing worldwide. The second most frequent cancer in men is prostate cancer which affects 1.41 million people worldwide (WHO statistics). Stevioside is an easily available item and it was observed to significantly inhibit cancer cell growth. Our study aims to analyze Molecular mechanisms underlying the chemopreventive anticancer activity of Stevioside on human prostate cancer cell lines. Prostate cancer cells were treated with Stevioside and the level of Bcl-2, Mcl-1, and Caspase-3 was estimated respectively. Data were expressed as the mean ± SD of 3 individual experiments performed in triplicate. Statistical analysis was performed using one-way ANOVA. In PC-3 cells, the effect of Stevioside extracts on cell viability was analyzed through MTT assay with a significant decrease in the percentage of viable cells with an increase in concentration, while the Mcl-1 gene with a decrease in fold change with a rise in concentration. Caspase 3 with a significant increase in fold change with an increase in concentration indicates effective apoptosis and also inhibits the Bcl-2 gene with a decrease in fold change with a rise in concentration with a significance of p<0.05. According to the results Stevioside extract considerably and strongly (by a significant fold change) suppresses the proliferation of cancer cells. The results imply that Stevioside may be turned into a natural prostate cancer medication and further investigation is necessary to establish the daily intake of Stevia products that is both safe and beneficial to the health of the human body.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135637455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ali Ghandaali, Mozhgan Mehri Ardestani, Saeid Hadi, Fatemeh Nejatbakhsh, Vahid Hadi, Mohammad Hassan Kazemi-Galougahi, Seyed Mahdi Mirghazanfari
{"title":"Effects of Almond Porridge, Grape Extract, and Pea Syrup on Fatigue Severity of Patients with COVID-19","authors":"Ali Ghandaali, Mozhgan Mehri Ardestani, Saeid Hadi, Fatemeh Nejatbakhsh, Vahid Hadi, Mohammad Hassan Kazemi-Galougahi, Seyed Mahdi Mirghazanfari","doi":"10.51847/pm4au8zr75","DOIUrl":"https://doi.org/10.51847/pm4au8zr75","url":null,"abstract":"","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":"104 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135506405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The prevalence of hemangiomas in children reaches 45.7% of all benign childhood tumors, among newborns up to 1/4 of children are affected by the disease. The complexity of diagnosing and treating hemangiomas is exacerbated by the lack of a unified classification capable of providing mutual understanding between pediatricians, dermatologists, pediatric surgeons, and oncologists. One of the generally recognized problems in the treatment of hemangiomas is the definition of indications for the start of treatment. A serious problem is the treatment of ulcerated hemangiomas, accompanied by infection and bleeding. The tactics of managing a patient with hemangioma require an individual approach. For example, propranolol therapy and laser removal of hemangiomas are the most effective, safe, and cosmetically acceptable methods of removal. Surgical treatment and electrocoagulation show a persistent, relapse-free effect. As part of the scientific work, a statistical study of 40 case histories of children was carried out. The article presents data on the distribution of the disease by sex, and age, as well as by location and method of treatment.
{"title":"Methods of Treatment of Hemangiomas","authors":"Luliia Vyacheslavna Nebotova, Elnur Gasanov, Sevil Husynbekovna Makhsubova, Zaira Arazovna Abdullayeva, Said-Magomed Said-Ibragimovich Shabaev, Ismail Askhatovich Kadiev","doi":"10.51847/3rby3fhp0j","DOIUrl":"https://doi.org/10.51847/3rby3fhp0j","url":null,"abstract":"The prevalence of hemangiomas in children reaches 45.7% of all benign childhood tumors, among newborns up to 1/4 of children are affected by the disease. The complexity of diagnosing and treating hemangiomas is exacerbated by the lack of a unified classification capable of providing mutual understanding between pediatricians, dermatologists, pediatric surgeons, and oncologists. One of the generally recognized problems in the treatment of hemangiomas is the definition of indications for the start of treatment. A serious problem is the treatment of ulcerated hemangiomas, accompanied by infection and bleeding. The tactics of managing a patient with hemangioma require an individual approach. For example, propranolol therapy and laser removal of hemangiomas are the most effective, safe, and cosmetically acceptable methods of removal. Surgical treatment and electrocoagulation show a persistent, relapse-free effect. As part of the scientific work, a statistical study of 40 case histories of children was carried out. The article presents data on the distribution of the disease by sex, and age, as well as by location and method of treatment.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":"1 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70811790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Magdalena Alvarez-Ramirez, L. Figueroa-Valverde, F. Díaz-Cedillo, M. Rosas-Nexticapa, M. Lopez-Ramos, Virginia Mateu-Armand, Lopez-Gutierrez Tomas
Several studies suggest that some drugs such as astemizole and tetrandine can inhibit the expression of Eag-1 in cancer cells. Analyzing these data, this study aimed to evaluate the theoretical interaction of furanone (compound 1) and its derivatives (compounds 2 to 30) with Eag-1 using the 7CN1 protein as a theoretical model; in addition, astemizole, tetrandine, N-(4-(2-(Diethylamino)ethoxy)phenyl)-2- nitro-4-(trifluoromethyl)-aniline (DNTA), 1-Dimethylamino-3-[4-(2-nitro-4-trifluoromethyl-phenyl-amino)-phenoxy]-propan-2-ol (ZVS-08), and 3-Chloro-N-{2-[3,5-dibromo-4-(3-di-methyl-amino-propoxy)-phenyl]-ethyl}-4-metho-xy-benzamide (PD) were used as controls in the DockingServer software. Results showed that interaction of compounds 1-30, DNTA, ZVS-08, and PD with 7CN1 protein surface involves different aminoacid residues. Besides, inhibition constant was lower for furanone derivatives 7, 12, 16, 20, 25, 26, 29, and 30 compared to astemizole, tetrandine, DNTA, ZVS-08, and PD. These data suggest that furanone derivatives 7, 12, 16, 20, 25, 26, 29, and 30 could act as Eag-1 inhibitors in cancer cells. Therefore, these furenone derivatives could be good candidates for the treatment of cancer.
{"title":"Theoretical Evaluation of Furanone and its Derivatives for the Treatment of Cancer Through Eag-1 Inhibition","authors":"Magdalena Alvarez-Ramirez, L. Figueroa-Valverde, F. Díaz-Cedillo, M. Rosas-Nexticapa, M. Lopez-Ramos, Virginia Mateu-Armand, Lopez-Gutierrez Tomas","doi":"10.51847/iviqzrp5lt","DOIUrl":"https://doi.org/10.51847/iviqzrp5lt","url":null,"abstract":"Several studies suggest that some drugs such as astemizole and tetrandine can inhibit the expression of Eag-1 in cancer cells. Analyzing these data, this study aimed to evaluate the theoretical interaction of furanone (compound 1) and its derivatives (compounds 2 to 30) with Eag-1 using the 7CN1 protein as a theoretical model; in addition, astemizole, tetrandine, N-(4-(2-(Diethylamino)ethoxy)phenyl)-2- nitro-4-(trifluoromethyl)-aniline (DNTA), 1-Dimethylamino-3-[4-(2-nitro-4-trifluoromethyl-phenyl-amino)-phenoxy]-propan-2-ol (ZVS-08), and 3-Chloro-N-{2-[3,5-dibromo-4-(3-di-methyl-amino-propoxy)-phenyl]-ethyl}-4-metho-xy-benzamide (PD) were used as controls in the DockingServer software. Results showed that interaction of compounds 1-30, DNTA, ZVS-08, and PD with 7CN1 protein surface involves different aminoacid residues. Besides, inhibition constant was lower for furanone derivatives 7, 12, 16, 20, 25, 26, 29, and 30 compared to astemizole, tetrandine, DNTA, ZVS-08, and PD. These data suggest that furanone derivatives 7, 12, 16, 20, 25, 26, 29, and 30 could act as Eag-1 inhibitors in cancer cells. Therefore, these furenone derivatives could be good candidates for the treatment of cancer.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":"1 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70824562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vijaya B. Ghule, A. Deshpande, Sushma G Gurwale, Tushar Kambale, Banymeen Iqbal
Chondroblastoma is a rare benign appearing lesion arising in the epiphysis of long bones in skeletally immature individuals. It is a cartilage-producing neoplasm constituting < 1% of all bone tumors. A 16 years old girl presented to orthopedic OPD of tertiary care hospital with swelling of her left great toe for 3 years. The swelling was insidious at onset and gradually progressed to the present size of 3.5x2.5x2 cm. Radiographic examination shows an osteolytic lesion and coarse trabeculation in the distal phalanx of the great toe suggestive of a benign bone tumor. Histopathological examination showed classical features of chondroblastoma. Post-operative follow-up was uneventful and radiological examination was normal. Flat bones like the pelvis, ribs, vertebrae, scapula, and craniofacial bones are other uncommon locations. The tumor recurrence rate is increased when the tumor is having limited resection due to the site of the tumor. Turcotte et al . reported the highest recurrence rate of tumors in flat temporal bones with recurrence within 6 months to 8 years. Chondroblastoma, an uncommon primary bone tumor presenting at the distal phalanx of the great toe was extremely rare.
{"title":"Chondroblastoma in a Distal Phalanx of the Great Toe – A Rare Case Report","authors":"Vijaya B. Ghule, A. Deshpande, Sushma G Gurwale, Tushar Kambale, Banymeen Iqbal","doi":"10.51847/ognfaljlxq","DOIUrl":"https://doi.org/10.51847/ognfaljlxq","url":null,"abstract":"Chondroblastoma is a rare benign appearing lesion arising in the epiphysis of long bones in skeletally immature individuals. It is a cartilage-producing neoplasm constituting < 1% of all bone tumors. A 16 years old girl presented to orthopedic OPD of tertiary care hospital with swelling of her left great toe for 3 years. The swelling was insidious at onset and gradually progressed to the present size of 3.5x2.5x2 cm. Radiographic examination shows an osteolytic lesion and coarse trabeculation in the distal phalanx of the great toe suggestive of a benign bone tumor. Histopathological examination showed classical features of chondroblastoma. Post-operative follow-up was uneventful and radiological examination was normal. Flat bones like the pelvis, ribs, vertebrae, scapula, and craniofacial bones are other uncommon locations. The tumor recurrence rate is increased when the tumor is having limited resection due to the site of the tumor. Turcotte et al . reported the highest recurrence rate of tumors in flat temporal bones with recurrence within 6 months to 8 years. Chondroblastoma, an uncommon primary bone tumor presenting at the distal phalanx of the great toe was extremely rare.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":"23 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70828401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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