S. Saeed, Aurazaib Abbasi, Abdul Sattar Muhammad Hashim
Cancers, especially of the neural tissue, are often deemed a death sentence. There is, however, still no clear understanding of the underlying causes nor the cellular and molecular mechanisms of this disease. The spread and collateral damage caused by various types of brain tumors remain poorly understood, despite the information that is currently available about these diseases. A common means of diagnosing tumors is through cerebrospinal fluid (CSF) leakage, and the enzymes from brain cancer cases were investigated within this hypothesis. The purpose of this study was to investigate the role of CSF in brain cancer and BBB. This study conducted a systematic study of leakage that typically occurs at the spine level, namely in the thoracic spine region and the base of the brain along the cardiothoracic connection. This study investigated the bacteria sampling of brain cancer in CSF and determined the common method of targeting cancer cells in the brain and enzymes contained within the CSF. A further finding reveals the precise foci of this leakage and various proteins and enzymes that may be responsible for this damage, as well as evidence that the release of tumor components damages the CSF. As a result of these observations, enzymes and tumor cells are detected, and a new component identifies tumor-related CSF.
{"title":"A Systematic Mapping Study of detection of Tumor Cell Targeted by Enzymes though Cerebrospinal Fluid","authors":"S. Saeed, Aurazaib Abbasi, Abdul Sattar Muhammad Hashim","doi":"10.51847/vqorizlqm3","DOIUrl":"https://doi.org/10.51847/vqorizlqm3","url":null,"abstract":"Cancers, especially of the neural tissue, are often deemed a death sentence. There is, however, still no clear understanding of the underlying causes nor the cellular and molecular mechanisms of this disease. The spread and collateral damage caused by various types of brain tumors remain poorly understood, despite the information that is currently available about these diseases. A common means of diagnosing tumors is through cerebrospinal fluid (CSF) leakage, and the enzymes from brain cancer cases were investigated within this hypothesis. The purpose of this study was to investigate the role of CSF in brain cancer and BBB. This study conducted a systematic study of leakage that typically occurs at the spine level, namely in the thoracic spine region and the base of the brain along the cardiothoracic connection. This study investigated the bacteria sampling of brain cancer in CSF and determined the common method of targeting cancer cells in the brain and enzymes contained within the CSF. A further finding reveals the precise foci of this leakage and various proteins and enzymes that may be responsible for this damage, as well as evidence that the release of tumor components damages the CSF. As a result of these observations, enzymes and tumor cells are detected, and a new component identifies tumor-related CSF.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":"1 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70837081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Borja Pérez-Domínguez, Pablo Garcia-Cerdan, Sara Perpiñá-Martínez, S. García-Isidoro, A. M. Rodriguez-Rodriguez, M. Blanco-Díaz
The objective of this review was to assess the effectiveness of therapeutic exercise interventions in respiratory muscle function and functional capacity in patients suffering from cancer. A systematic review was conducted from November to December 2022 in the following databases: MEDLINE (through its search engine PubMed), PEDro, EMBASE, LILACS, CINAHL, and Google Scholar. Results were reported according to the PRISMA guidelines, and the protocol was previously registered (PROSPERO: CRD42022379018). Two independent reviewers extracted data from the included studies. 12 randomized controlled trials, including 679 patients, were included in this systematic review. 11 assessed the effects of therapeutic exercise on respiratory muscle function, and 6 assessed the effects on functional capacity. The current evidence is limited, and studies offer heterogeneous results. Further studies should be developed implementing structured exercise protocols, and the effects of exercise on different cancer types should also be assessed. However, this review offers a first insight into the potential effectiveness of therapeutic exercise in respiratory muscle function impairment and functional capacity loss.
{"title":"Effects of exercise on respiratory muscle function and functional capacity in patients with cancer. Systematic review","authors":"Borja Pérez-Domínguez, Pablo Garcia-Cerdan, Sara Perpiñá-Martínez, S. García-Isidoro, A. M. Rodriguez-Rodriguez, M. Blanco-Díaz","doi":"10.51847/xiauv89yqr","DOIUrl":"https://doi.org/10.51847/xiauv89yqr","url":null,"abstract":"The objective of this review was to assess the effectiveness of therapeutic exercise interventions in respiratory muscle function and functional capacity in patients suffering from cancer. A systematic review was conducted from November to December 2022 in the following databases: MEDLINE (through its search engine PubMed), PEDro, EMBASE, LILACS, CINAHL, and Google Scholar. Results were reported according to the PRISMA guidelines, and the protocol was previously registered (PROSPERO: CRD42022379018). Two independent reviewers extracted data from the included studies. 12 randomized controlled trials, including 679 patients, were included in this systematic review. 11 assessed the effects of therapeutic exercise on respiratory muscle function, and 6 assessed the effects on functional capacity. The current evidence is limited, and studies offer heterogeneous results. Further studies should be developed implementing structured exercise protocols, and the effects of exercise on different cancer types should also be assessed. However, this review offers a first insight into the potential effectiveness of therapeutic exercise in respiratory muscle function impairment and functional capacity loss.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":"1 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70840292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the scientific literature, studies on the feasibility of using selenium nanoparticles in the development of pharmaceuticals are widely presented. The positive effects of selenium in the treatment of cancer, hepatitis C, thyroid disease, cardiovascular disease, asthma, and other diseases have been studied. This scientific paper presents the results of studies on the effect of selenium nanoparticles on the development of a cancerous tumor. The experiment was carried out on five groups of white laboratory mice, with group 1 (positive control) being healthy individuals; group 2 (negative control) - individuals infected with EPNT-5 cancer cells; group 3 (experiment) - infected individuals that received an injection of selenium nanoparticles; group 4 (experiment) - infected individuals that received an injection of selenium nanoparticles and immunoglobulin imG; group 5 (experiment) - infected individuals who received an injection of immunoglobulin imG. During the experiment, the development of the disease and the behavior of laboratory animals were monitored. After 4 weeks, blood was taken for a general and biochemical test, and the masses of the internal organs of laboratory mice were also examined.
{"title":"Study of the Antitumor Activity of Selenium Nanoparticles","authors":"Arina Romanovna Maslyakova, Sabina Arturovna Magomedova, Islam Nazirovich Romantsov, Sharip Magomedrasulovich Nurbagandov, Mikhail Nikolaevich Bulovin, Oleg Rodionoviсh Podobin","doi":"10.51847/yt84akubr0","DOIUrl":"https://doi.org/10.51847/yt84akubr0","url":null,"abstract":"In the scientific literature, studies on the feasibility of using selenium nanoparticles in the development of pharmaceuticals are widely presented. The positive effects of selenium in the treatment of cancer, hepatitis C, thyroid disease, cardiovascular disease, asthma, and other diseases have been studied. This scientific paper presents the results of studies on the effect of selenium nanoparticles on the development of a cancerous tumor. The experiment was carried out on five groups of white laboratory mice, with group 1 (positive control) being healthy individuals; group 2 (negative control) - individuals infected with EPNT-5 cancer cells; group 3 (experiment) - infected individuals that received an injection of selenium nanoparticles; group 4 (experiment) - infected individuals that received an injection of selenium nanoparticles and immunoglobulin imG; group 5 (experiment) - infected individuals who received an injection of immunoglobulin imG. During the experiment, the development of the disease and the behavior of laboratory animals were monitored. After 4 weeks, blood was taken for a general and biochemical test, and the masses of the internal organs of laboratory mice were also examined.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":"1 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70841595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Numerous tools and techniques such as vital stain, autofluorescence, exfoliative cytology, histomorphometry, etc. were explored in the detection of dysplasia, but have variable sensitivity and specificity. The present study evaluated the effect of toluidine blue in increasing the accuracy of histomorphometry analysis in detection of the dysplasia in OPMDs on exfoliative cytology. An experimental, observational, cross-sectional research was performed on patients attending dental hospitals and in oral health check-up camps suspected of having OPMDs. Cytology smear was collected using the standard protocol before and after the application of a toluidine blue stain over the lesion. Two pathologists performed the dysplasia grading and histomorphometry analysis. Chi-square and t-tests were carried out (p<0.05). The study observed a positive correlation between toluidine blue positivity and dysplasia in OPMDs. The toluidine blue stain sensitivity, specificity, Positive Predictive Value, and Negative predictive value were 39.53 %, 97.56, 97.14, and 43.58% respectively. Toluidine blue before the cytology smear does not improve the diagnostic accuracy of cytomorphometry. Further, there was no significant variation in cellular and nuclear morphometry parameters as compared to normal mucosa. Toluidine blue stain does not improve the efficacy of cytomorphometry in discriminating dysplasia on cytosmears. However, toluidine blue stain can assist clinicians in identifying potential areas of having a suspicion of dysplasia for scalpel biopsy.
{"title":"Absence of Synergistic Effect of Toluidine Blue and Cytomorphometry in Discriminating Dysplasia in Oral Exfoliative Cytology","authors":"Yashi Shrivastava, M. Yuwanati, N. Ganesh","doi":"10.51847/w62uz2a9o8","DOIUrl":"https://doi.org/10.51847/w62uz2a9o8","url":null,"abstract":"Numerous tools and techniques such as vital stain, autofluorescence, exfoliative cytology, histomorphometry, etc. were explored in the detection of dysplasia, but have variable sensitivity and specificity. The present study evaluated the effect of toluidine blue in increasing the accuracy of histomorphometry analysis in detection of the dysplasia in OPMDs on exfoliative cytology. An experimental, observational, cross-sectional research was performed on patients attending dental hospitals and in oral health check-up camps suspected of having OPMDs. Cytology smear was collected using the standard protocol before and after the application of a toluidine blue stain over the lesion. Two pathologists performed the dysplasia grading and histomorphometry analysis. Chi-square and t-tests were carried out (p<0.05). The study observed a positive correlation between toluidine blue positivity and dysplasia in OPMDs. The toluidine blue stain sensitivity, specificity, Positive Predictive Value, and Negative predictive value were 39.53 %, 97.56, 97.14, and 43.58% respectively. Toluidine blue before the cytology smear does not improve the diagnostic accuracy of cytomorphometry. Further, there was no significant variation in cellular and nuclear morphometry parameters as compared to normal mucosa. Toluidine blue stain does not improve the efficacy of cytomorphometry in discriminating dysplasia on cytosmears. However, toluidine blue stain can assist clinicians in identifying potential areas of having a suspicion of dysplasia for scalpel biopsy.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":"1 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70838448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Lopez-Ramos, L. Figueroa-Valverde, F. Díaz-Cedillo, M. Rosas-Nexticapa, Magdalena Alvarez-Ramirez
There are studies which suggest that some cannabinoids derivatives can produce effects on prostate cancer; however, the effect exerted on androgen receptor and 5 -reductase is very confusing; perhaps, this phenomenon is due to differences in the chemical structure of cannabinoids. The aim of this theoretical research was to evaluate the possible interaction of twenty-cannabinoids derivatives (compounds 1 to 20) with either androgen receptor or 5 -reductase enzyme using either 3L3X or 7BW1 proteins as the theoretical models. Besides, testosterone, dihydrotestosterone, dutasteride, finasteride and flutamide drugs were used as theoretical tools. The results showed higher affinity of cannabinoid derivatives 6, 13, 16 and 20 for the androgen receptor surface compared to testosterone, dihydrotestosterone and flutamide. In addition, other data indicate that cannabinoid derivatives 1, 3, 14 and 18 could have higher affinity by 5 -reductase enzyme compared with dutasteride and finasteride. All these data suggest that cannabinoid derivatives 6, 13, 16 and 20 could act as androgen receptor inhibitors. In addition, the cannabinoid analogs 1, 3, 14 and 18 could exert their biological activity as 5 -reductase enzyme inhibitors. This phenomenon could be translated as good candidates for the treatment of prostate cancer.
{"title":"Theoretical Evaluation of Twenty-Cannabinoid Derivatives on Either Androgen Receptor or 5α-Reductase Enzyme","authors":"M. Lopez-Ramos, L. Figueroa-Valverde, F. Díaz-Cedillo, M. Rosas-Nexticapa, Magdalena Alvarez-Ramirez","doi":"10.51847/5myimtzexf","DOIUrl":"https://doi.org/10.51847/5myimtzexf","url":null,"abstract":"There are studies which suggest that some cannabinoids derivatives can produce effects on prostate cancer; however, the effect exerted on androgen receptor and 5 -reductase is very confusing; perhaps, this phenomenon is due to differences in the chemical structure of cannabinoids. The aim of this theoretical research was to evaluate the possible interaction of twenty-cannabinoids derivatives (compounds 1 to 20) with either androgen receptor or 5 -reductase enzyme using either 3L3X or 7BW1 proteins as the theoretical models. Besides, testosterone, dihydrotestosterone, dutasteride, finasteride and flutamide drugs were used as theoretical tools. The results showed higher affinity of cannabinoid derivatives 6, 13, 16 and 20 for the androgen receptor surface compared to testosterone, dihydrotestosterone and flutamide. In addition, other data indicate that cannabinoid derivatives 1, 3, 14 and 18 could have higher affinity by 5 -reductase enzyme compared with dutasteride and finasteride. All these data suggest that cannabinoid derivatives 6, 13, 16 and 20 could act as androgen receptor inhibitors. In addition, the cannabinoid analogs 1, 3, 14 and 18 could exert their biological activity as 5 -reductase enzyme inhibitors. This phenomenon could be translated as good candidates for the treatment of prostate cancer.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":"1 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70813188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Oral Cancer Staging and Clinicopathologic Features Presenting to Oral & Maxillofacial Surgery Practice in Saudi Arabia","authors":"B. Jamal","doi":"10.51847/gdcamtoqll","DOIUrl":"https://doi.org/10.51847/gdcamtoqll","url":null,"abstract":"","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":"1 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70821273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Kaur, Deepika Mishra, A. Roychoudhury, M. Sharma, A. Bhalla, A. Mridha, A. Kakkar, Rahul Yadav, Sunny Kala, Shashwat Mishra
Multinucleated giant cells are commonly encountered in histopathology and are mostly a clue to diagnosis but sometimes pose a diagnostic confusion. The present study elucidates a case series of giant cell lesions (GCL) with emphasis on differential diagnosis and other investigations that contribute towards arriving at a final diagnosis. We also intended to devise an algorithmic approach for the accurate pathological characterization of these lesions. All the cases reported in the department from January 2018 to June 2019 were reviewed by pathologists and the total number of lesions where giant cells were diagnostic or an additional finding were included in this study. Twenty-five cases out of 1000 biopsies were diagnosed based on giant cell morphology. The most frequent lesions were central giant cell granuloma, followed by cherubism, hyperparathyroidism, peripheral giant cell granuloma, tuberculosis, and hybrid lesion. A systematic approach towards differential diagnosis for such cases and a diagnostic algorithm was devised which is being followed as per the reported spectrum of GCL. Radiological, serology, and sometimes ancillary staining techniques are essential for the accurate histopathological diagnosis of giant cell lesions. Our diagnostic algorithm helps narrow down the spectrum of investigations necessary to characterize these lesions, enabling for a swifter and more confident identification of the pathologies.
{"title":"Giant Cells Lesions of Oral and Maxillofacial Region – A Proposed Diagnostic Algorithm","authors":"H. Kaur, Deepika Mishra, A. Roychoudhury, M. Sharma, A. Bhalla, A. Mridha, A. Kakkar, Rahul Yadav, Sunny Kala, Shashwat Mishra","doi":"10.51847/jt6kjbfkdg","DOIUrl":"https://doi.org/10.51847/jt6kjbfkdg","url":null,"abstract":"Multinucleated giant cells are commonly encountered in histopathology and are mostly a clue to diagnosis but sometimes pose a diagnostic confusion. The present study elucidates a case series of giant cell lesions (GCL) with emphasis on differential diagnosis and other investigations that contribute towards arriving at a final diagnosis. We also intended to devise an algorithmic approach for the accurate pathological characterization of these lesions. All the cases reported in the department from January 2018 to June 2019 were reviewed by pathologists and the total number of lesions where giant cells were diagnostic or an additional finding were included in this study. Twenty-five cases out of 1000 biopsies were diagnosed based on giant cell morphology. The most frequent lesions were central giant cell granuloma, followed by cherubism, hyperparathyroidism, peripheral giant cell granuloma, tuberculosis, and hybrid lesion. A systematic approach towards differential diagnosis for such cases and a diagnostic algorithm was devised which is being followed as per the reported spectrum of GCL. Radiological, serology, and sometimes ancillary staining techniques are essential for the accurate histopathological diagnosis of giant cell lesions. Our diagnostic algorithm helps narrow down the spectrum of investigations necessary to characterize these lesions, enabling for a swifter and more confident identification of the pathologies.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":"1 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70825790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Srivarsha Ranjeet, M. Yuwanati, Senthil Murugan Mullainathan
Oral squamous cell carcinoma (OSCC) is one of the most common cancers. It accounts for 90–96% incidence of all head and neck cancers. Understanding molecular pathogenesis can pave the way for precision-based treatment as well as improve the quality of life. The aim of the present study was to investigate the effects of Gymnema sylvestre (GS) and Ethylenediaminetetraacetic acid (EDTA) on ctDNA yield in OSCC. The prospective study was conducted on 20 primary OSCC patients. The blood samples for patients taken and was preserved in tubes containing GS and EDTA. Polymerase chain reaction (PCR) was carried out to quantify the ctDNA. EDTA and GS have almost similar effects and similar yields on ctDNA from the blood of OSCC. It was concluded that apart from chemical anticoagulants like EDTA, GS can also be used as in-vitro laboratory anticoagulants for storing blood from OSCC, which can be used for molecular analysis.
{"title":"Effect of Herbal Anticoagulant on ctDNA Yield in Blood from Oral Squamous Cell Carcinoma Patients","authors":"Srivarsha Ranjeet, M. Yuwanati, Senthil Murugan Mullainathan","doi":"10.51847/ig4vvuiizr","DOIUrl":"https://doi.org/10.51847/ig4vvuiizr","url":null,"abstract":"Oral squamous cell carcinoma (OSCC) is one of the most common cancers. It accounts for 90–96% incidence of all head and neck cancers. Understanding molecular pathogenesis can pave the way for precision-based treatment as well as improve the quality of life. The aim of the present study was to investigate the effects of Gymnema sylvestre (GS) and Ethylenediaminetetraacetic acid (EDTA) on ctDNA yield in OSCC. The prospective study was conducted on 20 primary OSCC patients. The blood samples for patients taken and was preserved in tubes containing GS and EDTA. Polymerase chain reaction (PCR) was carried out to quantify the ctDNA. EDTA and GS have almost similar effects and similar yields on ctDNA from the blood of OSCC. It was concluded that apart from chemical anticoagulants like EDTA, GS can also be used as in-vitro laboratory anticoagulants for storing blood from OSCC, which can be used for molecular analysis.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":"37 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70823964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A BCR-ABL fusion product identifies chronic myeloid leukemia as a clonal myeloproliferative tumor. Tyrosine kinase inhibitors have become more widely used to treat chronic myeloid leukemia, although there is still little known about their long-term negative effects, such as the possibility of additional cancers. The most common secondary malignancies reported in CML are localized to the gastrointestinal tract, prostate, lung, non-Hodgkins lymphoma, malignant melanoma and breast cancer. Herein, we report a case of serous papillary adenocarcinoma of the ovary in a known case of chronic myeloid leukemia on imatinib therapy for the past three years. The 46-year-old lady presented to us with massive ascites. Cytological examination revealed features of a papillary adenocarcinoma. The cytological diagnosis was further confirmed by immunohistochemistry on the cell block. Secondary ovarian adenocarcinoma following imatinib therapy for chronic myeloid leukemia is uncommon with only one case reported to date. It is important to evaluate the long-term effects of imatinib therapy especially the risk of developing secondary malignancies.
{"title":"Secondary Ovarian Malignancy in an Imatinib treated Chronic Myeloid Leukemia Patient Diagnosed on Fluid Cytology","authors":"Kaveripakam Ajay Joseph, Sana Ahuja, S. Zaheer","doi":"10.51847/y7ma3ybrby","DOIUrl":"https://doi.org/10.51847/y7ma3ybrby","url":null,"abstract":"A BCR-ABL fusion product identifies chronic myeloid leukemia as a clonal myeloproliferative tumor. Tyrosine kinase inhibitors have become more widely used to treat chronic myeloid leukemia, although there is still little known about their long-term negative effects, such as the possibility of additional cancers. The most common secondary malignancies reported in CML are localized to the gastrointestinal tract, prostate, lung, non-Hodgkins lymphoma, malignant melanoma and breast cancer. Herein, we report a case of serous papillary adenocarcinoma of the ovary in a known case of chronic myeloid leukemia on imatinib therapy for the past three years. The 46-year-old lady presented to us with massive ascites. Cytological examination revealed features of a papillary adenocarcinoma. The cytological diagnosis was further confirmed by immunohistochemistry on the cell block. Secondary ovarian adenocarcinoma following imatinib therapy for chronic myeloid leukemia is uncommon with only one case reported to date. It is important to evaluate the long-term effects of imatinib therapy especially the risk of developing secondary malignancies.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":"1 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70841011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Iqbal, H. Kumar, V. Vishwanathan, Meesha Zaheer, C. Gore
Cancer of the urinary bladder is a commonly encountered malignancy of the urinary tract. The most common histologic type is Transitional cell carcinoma (TCC). It accounts for 90-95% of all bladder cancers. It is usually seen in the sixth and seventh decades of life. Men are affected three to four times more than women. The remaining 5-10% of the bladder tumors are other types of epithelial and mesenchymal tumors. Squamous cell carcinoma (SCC) of the urinary bladder is a very uncommon malignancy. It accounts for only 1-3% of all bladder cancers. Bladder tumors with only focal squamous differentiation are not diagnosed as SCC. Unfortunately, SCC of the urinary bladder is usually diagnosed at a late stage, and consequently, the prognosis is poor. The only proven predisposing factor implicated in the causation of SCC bladder is chronic irritation as by chronic urinary tract infections, bladder stones, schistosomiasis, etc. We present a case of SCC of the urinary bladder in a 70-year-old male patient who presented with hematuria, pain, and decreased frequency of micturition. A transurethral biopsy was performed at the site of the thickening of the bladder wall. The histopathological examination of the sampled tissue confirmed the diagnosis of a well-differentiated SCC.
{"title":"Urinary Bladder Primary Squamous Cell Carcinoma: A Rare Case Description and Literature Review","authors":"B. Iqbal, H. Kumar, V. Vishwanathan, Meesha Zaheer, C. Gore","doi":"10.51847/nnm18xsmgj","DOIUrl":"https://doi.org/10.51847/nnm18xsmgj","url":null,"abstract":"Cancer of the urinary bladder is a commonly encountered malignancy of the urinary tract. The most common histologic type is Transitional cell carcinoma (TCC). It accounts for 90-95% of all bladder cancers. It is usually seen in the sixth and seventh decades of life. Men are affected three to four times more than women. The remaining 5-10% of the bladder tumors are other types of epithelial and mesenchymal tumors. Squamous cell carcinoma (SCC) of the urinary bladder is a very uncommon malignancy. It accounts for only 1-3% of all bladder cancers. Bladder tumors with only focal squamous differentiation are not diagnosed as SCC. Unfortunately, SCC of the urinary bladder is usually diagnosed at a late stage, and consequently, the prognosis is poor. The only proven predisposing factor implicated in the causation of SCC bladder is chronic irritation as by chronic urinary tract infections, bladder stones, schistosomiasis, etc. We present a case of SCC of the urinary bladder in a 70-year-old male patient who presented with hematuria, pain, and decreased frequency of micturition. A transurethral biopsy was performed at the site of the thickening of the bladder wall. The histopathological examination of the sampled tissue confirmed the diagnosis of a well-differentiated SCC.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":"1 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70827656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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