Namita Singh, P. Pradhan, Ranjana Giri, Diptiranjan Satapathy
The Ki-67 Labelling Index (LI) is used as an ancillary tool to assess cell proliferation activity in glioma diagnosis. It is a potent biologic marker that estimates the growth of neoplasm and thus will aid in identifying the prognosis in patients with glioma. To study the expression of Ki-67 in astrocytic tumors and its correlation with clinicopathological parameters. Clinico-radiological details of forty-three cases of glioma were documented. H&E slides were reviewed for histopathological grade and morphology. KI-67 Labelling Index was studied by immunohistochemical analysis at ‘hot-spot’ areas. Cases were segregated into high and low grades taking 4% as a cut-off as per WHO criteria. Statistical analysis was carried out using standard statistical software with a p-value of ≤ 0.05 taken as statistically significant. A total of 43 patients were included comprising 31 males and 12 females with a mean age of 46.14 years. Ki-67 labeling index showed a statistically significant relationship with the advanced age (p=0.01), higher histological grade (p=<0.00001), presence of cellular atypia (p=0.0002), necrosis (p=<0.00001), and microvascular proliferation (p=<0.00001). Ki-67 assessment supplements standard histopathological grading. It is a simple and reliable method. This study demonstrates that it can serve as an important prognostic marker. It can be used as an adjunct to histopathological diagnosis.
{"title":"Role of Ki-67 as an Adjunct to Histopathological Diagnosis in the Grading of Astrocytic Tumors","authors":"Namita Singh, P. Pradhan, Ranjana Giri, Diptiranjan Satapathy","doi":"10.51847/oeraushysy","DOIUrl":"https://doi.org/10.51847/oeraushysy","url":null,"abstract":"The Ki-67 Labelling Index (LI) is used as an ancillary tool to assess cell proliferation activity in glioma diagnosis. It is a potent biologic marker that estimates the growth of neoplasm and thus will aid in identifying the prognosis in patients with glioma. To study the expression of Ki-67 in astrocytic tumors and its correlation with clinicopathological parameters. Clinico-radiological details of forty-three cases of glioma were documented. H&E slides were reviewed for histopathological grade and morphology. KI-67 Labelling Index was studied by immunohistochemical analysis at ‘hot-spot’ areas. Cases were segregated into high and low grades taking 4% as a cut-off as per WHO criteria. Statistical analysis was carried out using standard statistical software with a p-value of ≤ 0.05 taken as statistically significant. A total of 43 patients were included comprising 31 males and 12 females with a mean age of 46.14 years. Ki-67 labeling index showed a statistically significant relationship with the advanced age (p=0.01), higher histological grade (p=<0.00001), presence of cellular atypia (p=0.0002), necrosis (p=<0.00001), and microvascular proliferation (p=<0.00001). Ki-67 assessment supplements standard histopathological grading. It is a simple and reliable method. This study demonstrates that it can serve as an important prognostic marker. It can be used as an adjunct to histopathological diagnosis.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":"1 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70828327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Boujguenna, Fatima Ezzahra Ghlalou, A. Fakhri, A. Soummani, H. Rais
Granulosa cell tumors are malignant tumors that belong to the tumors of the sexual cords and the stroma. This study permitted us to analyze the granulosa tumors of 9 cases based on the data of the literature. Eight patients presented with adult-type granulosa ovarian tumors and only one patient presented with the juvenile. Patients ranged between ages 29 to 75 age were predominantly postmenopausal women (77.77%). The first conditions found of discovery were tumor syndrome with abdominopelvic pain by the tumor syndrome with abdomino-pelvic pain in first place (77.77%) and abdomino-pelvic masses (55.55%), followed by endocrine syndrome with metrorrhagia (22.22%), and finally signs of dysuria in one patient. On histological examination, the majority of our patients presented a typical microscopic appearance with a tumor proliferation of diffuse architecture with the presence of nuclear grooves in all our patients and Call-Exner bodies in two-thirds. Treatment of these tumors typically involves surgical resection, with the extent of surgery dictated by the stage of disease and the presence of associated comorbidities. Adjuvant chemotherapy and/or radiation therapy may be considered in select cases, but the optimal management strategy for ovarian granulosa tumors remains poorly defined given the rarity of the disease and the lack of large-scale clinical trials.
{"title":"Anatomopathological and Epidemiological Profile of Granulosa Tumors of the Ovary: About 9 Cases","authors":"I. Boujguenna, Fatima Ezzahra Ghlalou, A. Fakhri, A. Soummani, H. Rais","doi":"10.51847/ymklzp0sek","DOIUrl":"https://doi.org/10.51847/ymklzp0sek","url":null,"abstract":"Granulosa cell tumors are malignant tumors that belong to the tumors of the sexual cords and the stroma. This study permitted us to analyze the granulosa tumors of 9 cases based on the data of the literature. Eight patients presented with adult-type granulosa ovarian tumors and only one patient presented with the juvenile. Patients ranged between ages 29 to 75 age were predominantly postmenopausal women (77.77%). The first conditions found of discovery were tumor syndrome with abdominopelvic pain by the tumor syndrome with abdomino-pelvic pain in first place (77.77%) and abdomino-pelvic masses (55.55%), followed by endocrine syndrome with metrorrhagia (22.22%), and finally signs of dysuria in one patient. On histological examination, the majority of our patients presented a typical microscopic appearance with a tumor proliferation of diffuse architecture with the presence of nuclear grooves in all our patients and Call-Exner bodies in two-thirds. Treatment of these tumors typically involves surgical resection, with the extent of surgery dictated by the stage of disease and the presence of associated comorbidities. Adjuvant chemotherapy and/or radiation therapy may be considered in select cases, but the optimal management strategy for ovarian granulosa tumors remains poorly defined given the rarity of the disease and the lack of large-scale clinical trials.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":"1 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70841789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Ahmad, Mohannad Hameed Alwothaina, Majed Adi Albagami, Saleh Abdullah Saleh Alrajhi, Abdulaziz Mohammed Alammar, S. Ansari
Radiotherapy for head and neck cancer usually involves a total dose of 6000-7000 cGy, delivered daily in 6-7 weeks, and is known to cause several oral complications. These include oral mucositis, oral pain, insufficient saliva production, increased risk of dental caries, decreased mouth opening, and osteoradionecrosis. This is a cross-sectional study conducted among Saudi dental professionals using an online survey; 463 dentists from Riyadh City were utilized in this study. Findings reported that almost equal numbers of males (51.9%) and females (48.1%) participated in the study; the majority of them were working as general dentists in the government sector. A significantly significant proportion of them thought that oral assessment is a necessity before radiotherapy and that the ideal time for a complete oral evaluation is after the diagnosis of cancer. In the present study, we concluded that the majority of dentists thought that oral assessment is necessary before radiotherapy and that the ideal time is after the diagnosis. The evaluation must include extraction of teeth with poor prognosis, and radiotherapy after oral surgery should be started after 3-4 months. Teeth cleaning was recommended, and most dentists were not confident in treating oral cancer patients.
{"title":"Oral Complications of Radiotherapy for Head and Neck Cancer; Knowledge of Dentists in Riyadh, Saudi Arabia","authors":"S. Ahmad, Mohannad Hameed Alwothaina, Majed Adi Albagami, Saleh Abdullah Saleh Alrajhi, Abdulaziz Mohammed Alammar, S. Ansari","doi":"10.51847/zt1zshfr0l","DOIUrl":"https://doi.org/10.51847/zt1zshfr0l","url":null,"abstract":"Radiotherapy for head and neck cancer usually involves a total dose of 6000-7000 cGy, delivered daily in 6-7 weeks, and is known to cause several oral complications. These include oral mucositis, oral pain, insufficient saliva production, increased risk of dental caries, decreased mouth opening, and osteoradionecrosis. This is a cross-sectional study conducted among Saudi dental professionals using an online survey; 463 dentists from Riyadh City were utilized in this study. Findings reported that almost equal numbers of males (51.9%) and females (48.1%) participated in the study; the majority of them were working as general dentists in the government sector. A significantly significant proportion of them thought that oral assessment is a necessity before radiotherapy and that the ideal time for a complete oral evaluation is after the diagnosis of cancer. In the present study, we concluded that the majority of dentists thought that oral assessment is necessary before radiotherapy and that the ideal time is after the diagnosis. The evaluation must include extraction of teeth with poor prognosis, and radiotherapy after oral surgery should be started after 3-4 months. Teeth cleaning was recommended, and most dentists were not confident in treating oral cancer patients.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":"1 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70844008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Liposarcoma is the most common malignant soft tissue tumor in adults. Extremities and retroperitoneum are the common sites of involvement of liposarcoma. Liposarcoma of the gastrointestinal tract is rare and the colon is an extremely uncommon site. Mesenchymal tumors of the bowel are mainly represented by gastrointestinal stromal tumors (GIST). A sixty-one-year-old male patient presented with abdominal pain and distension. Contrast-enhanced computerized tomography (CECT) showed a circumferentially proliferative mass lesion in the mid ascending colon causing acute colonic obstruction with multiple large enhancing exophytic mass lesions of varying sizes on the peritoneal surface of the intestine. A right hemicolectomy was done. Gross examination showed polypoidal growth of 3.5x3x1.5 cm in the luminal aspect of ascending colon and a large exophytic firm mass in the transverse colon of 15x5.5x5 cm. There were multiple smaller exophytic nodules on the serosal aspect of the intestine. Microscopy showed neoplasm composed of atypical spindle cells in ill-defined fascicles and whorls. Foci showing aggregates of adipocytes of varying sizes with occasional lipoblasts were also noted. The spindly cells were Ckit negative, DOG 1 negative, and showed positivity for SMA. Based on morphology and immunoprofile, a diagnosis of dedifferentiated liposarcoma was given. This case represents dedifferentiated liposarcoma presenting as single endophytic and multiple exophytic masses and highlights the fact that, although rare, dedifferentiated liposarcoma can present as multiple intestinal mass lesions.
{"title":"Primary Dedifferentiated Liposarcoma of the Colon - Report of a Rare Case with Review of Literature","authors":"R. Sukumaran, Preethy T Ramadas, S. Raveendran","doi":"10.51847/cjmcwvvgbh","DOIUrl":"https://doi.org/10.51847/cjmcwvvgbh","url":null,"abstract":"Liposarcoma is the most common malignant soft tissue tumor in adults. Extremities and retroperitoneum are the common sites of involvement of liposarcoma. Liposarcoma of the gastrointestinal tract is rare and the colon is an extremely uncommon site. Mesenchymal tumors of the bowel are mainly represented by gastrointestinal stromal tumors (GIST). A sixty-one-year-old male patient presented with abdominal pain and distension. Contrast-enhanced computerized tomography (CECT) showed a circumferentially proliferative mass lesion in the mid ascending colon causing acute colonic obstruction with multiple large enhancing exophytic mass lesions of varying sizes on the peritoneal surface of the intestine. A right hemicolectomy was done. Gross examination showed polypoidal growth of 3.5x3x1.5 cm in the luminal aspect of ascending colon and a large exophytic firm mass in the transverse colon of 15x5.5x5 cm. There were multiple smaller exophytic nodules on the serosal aspect of the intestine. Microscopy showed neoplasm composed of atypical spindle cells in ill-defined fascicles and whorls. Foci showing aggregates of adipocytes of varying sizes with occasional lipoblasts were also noted. The spindly cells were Ckit negative, DOG 1 negative, and showed positivity for SMA. Based on morphology and immunoprofile, a diagnosis of dedifferentiated liposarcoma was given. This case represents dedifferentiated liposarcoma presenting as single endophytic and multiple exophytic masses and highlights the fact that, although rare, dedifferentiated liposarcoma can present as multiple intestinal mass lesions.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":"1 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70817154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sameera G Nath, Ranjith Raveendran, Suresh Perumbure
Dentistry has transformed, and digitization in Dentistry is now possible through Artificial Intelligence. Artificial Intelligence is an emerging field of technology, which simulate human intelligence in machines that are programmed to think like humans and mimic our actions. Although in the recent past several articles have highlighted the applications of Artificial Intelligence in screening and detecting oral cancers, less is known about how the technology helps in that aspect. In high-risk countries like India, Pakistan, Sri Lanka, Bangladesh, etc. oral cancer is the most common cancer in men, with up to 25% of all new cases. Early diagnosis of oral cancer is necessary since most patients report late and are diagnosed at a late stage of the disease, leading to a poor prognosis. Artificial intelligence can help in the early detection of oral cancer, thus helping in early diagnosis and possible help in the prediction of the prognosis of the disease. This article focuses on the lesser-known side of Artificial Intelligence, its role in the early detection of oral cancers, and how it actually can be put to use for the benefit of the dental profession and society at large. The concept of Artificial Intelligence is explained in this operative technique article with the help of the technology provider through unique diagrams for ease of understanding.
{"title":"Artificial Intelligence and Its Application in the Early Detection of Oral Cancers","authors":"Sameera G Nath, Ranjith Raveendran, Suresh Perumbure","doi":"10.51847/h7wa0uhoif","DOIUrl":"https://doi.org/10.51847/h7wa0uhoif","url":null,"abstract":"Dentistry has transformed, and digitization in Dentistry is now possible through Artificial Intelligence. Artificial Intelligence is an emerging field of technology, which simulate human intelligence in machines that are programmed to think like humans and mimic our actions. Although in the recent past several articles have highlighted the applications of Artificial Intelligence in screening and detecting oral cancers, less is known about how the technology helps in that aspect. In high-risk countries like India, Pakistan, Sri Lanka, Bangladesh, etc. oral cancer is the most common cancer in men, with up to 25% of all new cases. Early diagnosis of oral cancer is necessary since most patients report late and are diagnosed at a late stage of the disease, leading to a poor prognosis. Artificial intelligence can help in the early detection of oral cancer, thus helping in early diagnosis and possible help in the prediction of the prognosis of the disease. This article focuses on the lesser-known side of Artificial Intelligence, its role in the early detection of oral cancers, and how it actually can be put to use for the benefit of the dental profession and society at large. The concept of Artificial Intelligence is explained in this operative technique article with the help of the technology provider through unique diagrams for ease of understanding.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":"1 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70822176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Rosas-Nexticapa, L. Figueroa-Valverde, Magdalena Alvarez-Ramirez, M. Lopez-Ramos, Virginia Mateu-Armand, Tomas Lopez-Gutierrez
{"title":"Evaluation of Interaction of Some Quinolone Derivatives on RSK-4 Using a Theoretical Model","authors":"M. Rosas-Nexticapa, L. Figueroa-Valverde, Magdalena Alvarez-Ramirez, M. Lopez-Ramos, Virginia Mateu-Armand, Tomas Lopez-Gutierrez","doi":"10.51847/wrql2guumm","DOIUrl":"https://doi.org/10.51847/wrql2guumm","url":null,"abstract":"","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":"1 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70839136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Glioblastomas multiformes (GBMs), are the most common primary malignant tumors of the Central Nervous System. Frequently located in supratentorial topography, infratentorial location is rare, around 0-3.4% of primary GBMs. The diagnosis of these tumors is uncommon in adults, few cases have been reported, being even more infrequent in elderly patients. The most typical clinical presentation is a rapidly growing posterior fossa lesion, increased intracranial pressure, and cerebellar signs associated with the mass and perilesional edema. Clinical presentation, computed tomography (CT), and magnetic resonance imaging (MRI) provide useful information about the possible diagnosis but are not definitive. We describe a clinical case, 76 years old female with a clinical history of hypertension, depressive syndrome, and dyslipidemia. Started progressively with ataxy, imbalance, and vertigo. Brain CT shows an intra-axial, infiltrative lesion in the superior and middle vermis. MRI presents a heterogeneous lesion in the superior and median vermian region of the cerebellum with ring enhancement and central necrotic area. Was performed a middle suboccipital approach, corticectomy in the superior vermis. The intraoperative histological study reveal a high-grade malignancy astrocytoma, which was released through a subtotal resection. The histological result was a high-grade astrocytoma, grade IV in WHO classification. Four weeks after the surgery the patient started treatment with chemotherapy and radiotherapy. The main point of this case is the atypical location of the tumor. These lesions are rare in this location but they will do considering the differential diagnosis of posterior fossa tumors. However, the most frequent lesions with high percentages of incidence are metastatic lesions.
{"title":"Posterior Fossa Glioblastoma, Case Report, and Reviewed Literature","authors":"Gonçalo Januário","doi":"10.51847/jmhysnjkhu","DOIUrl":"https://doi.org/10.51847/jmhysnjkhu","url":null,"abstract":"Glioblastomas multiformes (GBMs), are the most common primary malignant tumors of the Central Nervous System. Frequently located in supratentorial topography, infratentorial location is rare, around 0-3.4% of primary GBMs. The diagnosis of these tumors is uncommon in adults, few cases have been reported, being even more infrequent in elderly patients. The most typical clinical presentation is a rapidly growing posterior fossa lesion, increased intracranial pressure, and cerebellar signs associated with the mass and perilesional edema. Clinical presentation, computed tomography (CT), and magnetic resonance imaging (MRI) provide useful information about the possible diagnosis but are not definitive. We describe a clinical case, 76 years old female with a clinical history of hypertension, depressive syndrome, and dyslipidemia. Started progressively with ataxy, imbalance, and vertigo. Brain CT shows an intra-axial, infiltrative lesion in the superior and middle vermis. MRI presents a heterogeneous lesion in the superior and median vermian region of the cerebellum with ring enhancement and central necrotic area. Was performed a middle suboccipital approach, corticectomy in the superior vermis. The intraoperative histological study reveal a high-grade malignancy astrocytoma, which was released through a subtotal resection. The histological result was a high-grade astrocytoma, grade IV in WHO classification. Four weeks after the surgery the patient started treatment with chemotherapy and radiotherapy. The main point of this case is the atypical location of the tumor. These lesions are rare in this location but they will do considering the differential diagnosis of posterior fossa tumors. However, the most frequent lesions with high percentages of incidence are metastatic lesions.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":"1 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70825343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Iqbal, Tushar Kambale, C. Gore, V. Vishwanathan, Arpana A. Dharwadkar
{"title":"Frantz's Tumor an Unusual Pancreatic Neoplasm with Rare Presentation","authors":"B. Iqbal, Tushar Kambale, C. Gore, V. Vishwanathan, Arpana A. Dharwadkar","doi":"10.51847/nsr50zkrc5","DOIUrl":"https://doi.org/10.51847/nsr50zkrc5","url":null,"abstract":"","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":"1 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70827497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The goal of this study was to clarify the role of p16 INK4a , p14 ARF, and p53 protein expressions in carcinogenesis in squamous cell carcinomas of the lip. The expressions of the p53, p16 INK4a , and p14 ARF proteins were examined in 46 formaline-fixed paraffin embedded tissue specimens, which included 19 cases of squamous cell carcinoma of the lip, 14 cases of actinic cheilitis, and 13 cases of normal mucosa. Immunoreactivity in the peritumoral epithelium adjacent to squamous cell carcinomas was also evaluated. p16 INK4a expression was increased in actinic cheilitis in comparison with normal mucosa (p=0.001). p14 ARF expression progressively increased from normal mucosa to actinic cheilitis (p=0.001) and was observed to decrease significantly during the process of transition from actinic cheilitis to carcinoma (p=0.003). p53 values progressively increased from normal mucosa to actinic cheilitis (p=0.001) and carcinoma (p=0.008). A significant positive correlation was found between p14 ARF and p53 in the peritumoral epithelium adjacent to carcinomas. Our findings indicated that p16 INK4a and p14 ARF immunohistochemistry does not determine whether or not actinic cheilitis has the potential to develop carcinoma. The p14 ARF /p53 pathway is activated in the peritumoral epithelium adjacent to carcinoma; however, this activation would not be adequate to prevent carcinogenesis.
{"title":"p16 INK4a , and p14 ARF Expressions in Carcinogenesis of Squamous Cell Carcinoma of the Lip","authors":"A. Akatlı, E. Ayva, O. Bozdogan","doi":"10.51847/vezzdfupif","DOIUrl":"https://doi.org/10.51847/vezzdfupif","url":null,"abstract":"The goal of this study was to clarify the role of p16 INK4a , p14 ARF, and p53 protein expressions in carcinogenesis in squamous cell carcinomas of the lip. The expressions of the p53, p16 INK4a , and p14 ARF proteins were examined in 46 formaline-fixed paraffin embedded tissue specimens, which included 19 cases of squamous cell carcinoma of the lip, 14 cases of actinic cheilitis, and 13 cases of normal mucosa. Immunoreactivity in the peritumoral epithelium adjacent to squamous cell carcinomas was also evaluated. p16 INK4a expression was increased in actinic cheilitis in comparison with normal mucosa (p=0.001). p14 ARF expression progressively increased from normal mucosa to actinic cheilitis (p=0.001) and was observed to decrease significantly during the process of transition from actinic cheilitis to carcinoma (p=0.003). p53 values progressively increased from normal mucosa to actinic cheilitis (p=0.001) and carcinoma (p=0.008). A significant positive correlation was found between p14 ARF and p53 in the peritumoral epithelium adjacent to carcinomas. Our findings indicated that p16 INK4a and p14 ARF immunohistochemistry does not determine whether or not actinic cheilitis has the potential to develop carcinoma. The p14 ARF /p53 pathway is activated in the peritumoral epithelium adjacent to carcinoma; however, this activation would not be adequate to prevent carcinogenesis.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":"1 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70836694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a rare subtype of Hodgkin lymphoma (HL) characterized by a distinct morphology, an older median age at onset, less incidence of mediastinal involvement, more frequent relapse and better prognosis as compared to Classical-HL (CHL). In contrast to CHL, the tumor cell (LP cell) of NLPHL almost always retains its B cell phenotype and is a CD30 non-expresser. Due to its rarity, only a handful of studies on this entity are available in the literature. We present a short case series of 10 cases of NLPHL diagnosed in our institute over 10 years. A total of 10 cases of NLPHL were retrospectively accessed, re-evaluated and classified further, based on various morphological patterns and immunophenotypic expression. Morphological patterns were correlated with overall the prognosis. Our study showed peripheral lymph node localization and overall good outcome in these cases. We also came across two unique cases, one was of NLPHL with Rosai-Dorfman disease (RDD) and another was of composite lymphoma showing components of NLPHL and Diffuse Large B cell Lymphoma (DLBCL).
{"title":"Nodular Lymphocyte Predominant Hodgkin Lymphoma: A Rare Subtype with Distinct Clinicopathological Features","authors":"Shreya Bramhe, Seema Rao, S. Dhawan","doi":"10.51847/xivrdleect","DOIUrl":"https://doi.org/10.51847/xivrdleect","url":null,"abstract":"Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a rare subtype of Hodgkin lymphoma (HL) characterized by a distinct morphology, an older median age at onset, less incidence of mediastinal involvement, more frequent relapse and better prognosis as compared to Classical-HL (CHL). In contrast to CHL, the tumor cell (LP cell) of NLPHL almost always retains its B cell phenotype and is a CD30 non-expresser. Due to its rarity, only a handful of studies on this entity are available in the literature. We present a short case series of 10 cases of NLPHL diagnosed in our institute over 10 years. A total of 10 cases of NLPHL were retrospectively accessed, re-evaluated and classified further, based on various morphological patterns and immunophenotypic expression. Morphological patterns were correlated with overall the prognosis. Our study showed peripheral lymph node localization and overall good outcome in these cases. We also came across two unique cases, one was of NLPHL with Rosai-Dorfman disease (RDD) and another was of composite lymphoma showing components of NLPHL and Diffuse Large B cell Lymphoma (DLBCL).","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":"1 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70840348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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