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Psychiatric Disorders in Children of Parents With Substance Dependence Disorder 父母有物质依赖障碍的儿童的精神障碍
IF 1.1 Q3 Medicine Pub Date : 2020-08-04 DOI: 10.1097/ADT.0000000000000216
T. Okasha, Nesreen M. Ibrahim, Rehab Naguib, Kerolos B. Khalil, R. Hashem
Objectives: Children of addicted parents exhibit depression, anxiety, and elevated rates of psychiatric disorders more frequently than do children from nonaddicted families. Hence, we conducted this research to illustrate the psychiatric illness of children of substance-dependent parents. Materials and Methods: The study included 50 children [25 with a parent diagnosed with substance use disorder according Diagnostic and Statistical Manual of Mental Disorders-4th edition criteria (group A), and 25 whose parents had no psychiatric diagnosis according to general health questionnaire (group B)]. The subjects were recruited from the Heliopolis Psychiatric Hospital, which is a Ministry of Health Hospital. They were assessed using the Mini-International Neuropsychiatric Interview for Children and Adolescents (MINI KID) scale. We, furthermore, assessed the relation between the Addiction Severity Index, type of substance used by group A parents, and the MINI KID scale. Results: Group A showed more significant diagnosis than group B (P=0.037) by the MINI KID scale (major depressive disorder, dysthymia, panic disorder, agoraphobia, and separation anxiety disorder) (P=0.018, 0.037, 0.042, 0.021, and 0.004, respectively). Hence, the substance abuse parent has a detrimental effect on their children’s well-being. As regards the relation between addiction severity and result of MINI KID scale in group A, only “employment” was significant (P=0.025). Surprisingly, neither the severity of substance abused nor the type of substance abused by the parent had significant relation with the diagnosed psychiatric disorders in their children. Conclusions: Our study found that the prevalence of psychiatric disorders in children increases when their parents have substance use disorder. Moreover, the variation of the severity of parent addiction does not affect the risk for having psychiatric disorders in their children.
目的:成瘾父母的孩子比非成瘾家庭的孩子更容易表现出抑郁、焦虑和精神疾病的高发率。因此,我们进行了这项研究,以说明精神疾病的物质依赖的父母的孩子。材料与方法:本研究纳入50例儿童[父母一方根据《精神障碍诊断与统计手册》第4版标准诊断为物质使用障碍的25例(a组),父母一方根据一般健康问卷诊断为无精神疾病的25例(B组)]。受试者是从Heliopolis精神病医院招募的,该医院是卫生部医院。他们使用迷你国际儿童和青少年神经精神病学访谈(MINI KID)量表进行评估。我们进一步评估了成瘾严重程度指数、A组父母使用的物质类型和MINI KID量表之间的关系。结果:A组在MINI KID量表(重度抑郁障碍、心境恶劣、惊恐障碍、广场恐怖症、分离焦虑障碍)上的诊断显著性高于B组(P=0.037) (P分别为0.018、0.037、0.042、0.021、0.004)。因此,滥用药物的父母对孩子的健康有不利的影响。A组成瘾严重程度与MINI KID量表结果的关系中,只有“就业”项有显著性差异(P=0.025)。令人惊讶的是,父母滥用药物的严重程度和滥用药物的类型与孩子的精神疾病诊断没有显著关系。结论:我们的研究发现,当父母有物质使用障碍时,儿童精神疾病的患病率会增加。此外,父母成瘾程度的差异并不影响其子女患精神疾病的风险。
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引用次数: 0
Evaluation of Methadone Maintenance Treatment in Armenia, Colombia: A Cross-sectional Study Responding to a National Priority 美沙酮维持治疗在亚美尼亚、哥伦比亚的评价:一项响应国家优先事项的横断面研究
IF 1.1 Q3 Medicine Pub Date : 2020-07-29 DOI: 10.1097/ADT.0000000000000219
Juan P. Borda, Luz G. Gutiérrez, L. López, Deivi A. Orrego
Colombia has experienced a dramatic increase of heroin use in the last 3 decades, stablishing the first methadone maintenance treatment (MMT) program in 2004. Although international evidence indicates that MMT has important benefits for people with opioid use disorder, technical and logistical difficulties have been identified in Colombia that can compromise the effectiveness of this treatment modality. In this cross-sectional study, a total of 148 subjects with opioid use disorder were interviewed in the city of Armenia (Colombia) using the Opiate Treatment Index, comparing the drug use, social functioning, human immunodeficiency virus risk behaviors, criminal activity, and the physical/mental health among subjects involved in MMT and those not receiving treatment. Despite the above-mentioned difficulties, subjects participating in MMT reported less illegal substance use (specifically heroin and basuco), less human immunodeficiency virus risk behaviors, better social functioning, less criminal activity, and less physical and mental health problems than those not receiving treatment. In addition, subjects involved in MMT reported a daily use of heroin and lower than recommended dosages of methadone. Therefore, Colombia should continue expandingMMTprograms across the country, integrating the available harm reduction strategies and providing continuous training for health professionals in charge of these programs.
哥伦比亚在过去30年中经历了海洛因使用的急剧增加,2004年建立了第一个美沙酮维持治疗(MMT)项目。尽管国际证据表明MMT对阿片类药物使用障碍患者有重要益处,但哥伦比亚已经发现技术和后勤方面的困难可能会影响这种治疗方式的有效性。在这项横断面研究中,共有148名阿片类药物使用障碍受试者在亚美尼亚(哥伦比亚)市使用阿片类治疗指数进行了访谈,比较了参与MMT和未接受治疗的受试者的药物使用、社会功能、人类免疫缺陷病毒风险行为、犯罪活动和身心健康。尽管存在上述困难,参与MMT的受试者报告称,与未接受治疗的受试对象相比,非法药物使用(特别是海洛因和巴苏科)更少,人类免疫缺陷病毒风险行为更少,社会功能更好,犯罪活动更少,身心健康问题更少。此外,参与MMT的受试者报告每天使用海洛因,美沙酮的剂量低于推荐剂量。因此,哥伦比亚应继续在全国范围内扩大MMT项目,整合现有的减少伤害战略,并为负责这些项目的卫生专业人员提供持续培训。
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引用次数: 1
Ego State Therapy for the Treatment of Grief and Loss After Death 自我状态疗法治疗死亡后的悲伤和损失
IF 1.1 Q3 Medicine Pub Date : 2020-07-21 DOI: 10.1097/ADT.0000000000000215
G. S. Sugara, Y. Yulianingsih, F. N. Isti’adah, S. Adiputra, Muhammad Muhajirin, R. P. Fadli, I. Ifdil
Losing a parent causes grief that impacts the development among adolescents. This often leads to self-internalization problems, such as depression and trauma. Without intervention, grief due to parental death may cause various effects over time. This study used a single case research technique with AB design to analyze the effectiveness of ego state therapy in reducing grief. The subjects consist of 2 adolescents living in the Orphanage with prolonged grief disorder. The results of the study showed a decrease in the level of grief during and after treatment. Ego state therapy can be used to improve the conditions of adolescents experiencing grief.
失去父母会带来悲伤,影响青少年的发展。这通常会导致自我内化问题,比如抑郁和创伤。如果不进行干预,父母死亡带来的悲伤可能会随着时间的推移产生各种影响。本研究采用单个案研究方法,结合AB设计,分析自我状态疗法在减轻悲伤方面的效果。研究对象包括两名生活在孤儿院的患有长期悲伤障碍的青少年。研究结果显示,在治疗期间和治疗后,悲伤程度有所下降。自我状态疗法可以用来改善青少年经历悲伤的状况。
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引用次数: 0
Feeling Death, Being Alive: 4-Methylethcathinone/Pentedrone Addiction and 3-Methoxyphencyclidine Intoxication 感觉死亡,活着:4-甲基乙卡西酮/戊酮成瘾和3-甲氧基苯环利定中毒
IF 1.1 Q3 Medicine Pub Date : 2020-07-07 DOI: 10.1097/ADT.0000000000000214
L. R. V. D. Bersselaar, J. G. V. D. Hoeven, B. D. Jong
New psychoactive substances (NPS), also known as designer drugs or legal highs, represent a broad range of different pharmacologically active substances. They are sold as replacements to established drugs such as cocaine, heroin, cannabis, and methylenedioxymethamphetamine. Among adolescents in Europe, NPS are gaining popularity. Despite the increasing use of NPS, information about the acute health effects remains scarce and is evenworse for the long-term effects or the addictive potential of NPS. Severe or fatal cases of NPS intoxications are reported. Although several authors warn about the addictive potential of synthetic cathinones, case reports or larger studies in humans are scarce. We present the case of a patient addicted to 4-methylethcathinone/pentedrone and an acute intoxication with 3-methoxyphencyclidine-piperidine cyclohexane carbonitrile. This case shows that the addictive potential of synthetic cathinones should not be underestimated.
新型精神活性物质(NPS),也称为设计药物或法定兴奋剂,代表了一系列不同的药理学活性物质。它们被作为可卡因、海洛因、大麻和亚甲二氧基甲基苯丙胺等既定药物的替代品出售。在欧洲青少年中,NPS越来越受欢迎。尽管NPS的使用越来越多,但有关其急性健康影响的信息仍然很少,而且对于NPS的长期影响或成瘾潜力来说更为严重。报告了严重或致命的NPS中毒病例。尽管几位作者对合成卡西酮的成瘾潜力提出了警告,但很少有病例报告或更大规模的人类研究。我们报告了一例对4-甲基乙卡西酮/戊烯酮上瘾的患者和一例对3-甲氧基苯环啶-哌啶-环己烷腈急性中毒的患者。这一案例表明,合成卡西酮的成瘾潜力不容低估。
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引用次数: 0
Emotion Regulation, Impulsivity, and Personality Profile Among Egyptian Patients With Substance Use Disorders 埃及物质使用障碍患者的情绪调节、冲动和个性特征
IF 1.1 Q3 Medicine Pub Date : 2020-06-12 DOI: 10.1097/ADT.0000000000000213
T. Okasha, Afaf Abd elsamie, H. Azzam, D. Elserafi, E. Shorub, Y. Elhawary, M. Morsy
Objectives: Emotion regulation deficits and impulsivity and personality profile as well play a role in the development and maintenance of substance use disorder (SUD). We aimed to examine the emotion regulation and both impulsivity and personality profile among patients with SUDs and its correlates. Patients and Methods: One hundred male patients with SUDs were selected from the inpatient and outpatient departments compared with 100 healthy controls matched for age, sex, and education. Structured Clinical Interview for the diagnostic and statistical manual of mental disorders (SCID-I); Temperement and Character Inventory, Barratt Impulsiveness Scale, Version 11 (BIS-11); and Trait Meta Mood Scale (TMMS) were used. Results: Emotional repair was significantly lower in cases compared with control group (P<0.05). Novelty seeking was significantly higher in patients with substance use. Meanwhile, cases had significantly lower scores in harm avoidance and persistence (P<0.01). In addition, cases showed significantly higher total, motor, attention, and nonplan scores of BIS compared with the control group (P<0.05). Furthermore, there was a negative correlation between attention to feeling, clarity of feeling, and repair of mood, and motor, attention, nonplan, and total scores of BIS. Meanwhile, there was a negative correlation between emotional repair and novelty seeking, harm avoidance, persistence, and self-transcendence. Conclusion: Deficits in emotional repair correlated with certain personality traits and impulsiveness may place individuals at more risk for SUD and are important variables to attend for propermanagement of SUD patients.
目的:情绪调节缺陷、冲动性和人格特征在物质使用障碍(SUD)的发展和维持中发挥作用。我们旨在研究SUDs患者的情绪调节、冲动性和个性特征及其相关性。患者和方法:从住院和门诊部选择100名男性SUD患者,与100名年龄、性别和教育程度匹配的健康对照组进行比较。精神障碍诊断和统计手册结构化临床访谈(SCID-I);脾气和性格量表,巴拉特冲动量表,第11版(BIS-11);使用特质元情绪量表(TMMS)。结果:与对照组相比,病例的情绪修复显著降低(P<0.05),药物使用组的求新率显著升高。同时,病例在回避伤害和持续伤害方面的得分显著低于对照组(P<0.01)。此外,与对照组相比,病例的BIS总分、运动、注意力和非计划得分显著较高(P<0.05),BIS总分。同时,情绪修复与寻求新奇、避免伤害、坚持和自我超越之间存在负相关。结论:与某些人格特征和冲动相关的情绪修复缺陷可能会使个体面临更大的SUD风险,并且是SUD患者正确管理的重要变量。
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引用次数: 1
Can High Altitude Exacerbate a Remittent Alcohol Use Disorder in a Patient With a History of Panic Attacks? 高海拔地区会加重有惊恐发作史的患者的轻度酒精使用障碍吗?
IF 1.1 Q3 Medicine Pub Date : 2020-06-01 DOI: 10.1097/ADT.0000000000000183
M. G. Carbone, M. Maiello, Giovanni Pagni, C. Tagliarini, B. Pacciardi, I. Maremmani
Background: Several studies have already investigated the brief and long-term neurological effects of exposure to high altitudes and the related sequelae of hypoxia on memory and cognition, but few authors have discussed the question of psychic symptoms during high-altitude activities. These authors suspect that the reexacerbation or worsening of psychiatric symptoms may well be the expression of maladaptive behaviors in response to changes in environmental conditions. Case Report: We describe the case of a patient with a history of sporadic Panic Attacks with elements of the panicagoraphobic spectrum (social phobia and separation anxiety) who, in a specific social context during adolescence, tended to misuse alcohol for recreational and disinhibitory purposes to solve his relational problems in the social sphere. After many years of abstinence, this patient decided to accept exposure to high altitudes at work and developed a serious alcohol use disorder, including the progressive worsening of his functioning in the social and working dimensions. Discussion: We propose that, because of the daily experiencing of high altitudes at work, the patient’s anxiety levels rose sharply, but unconsciously and automatically, according to a mode of copying previously enacted in adolescence (through social phobia and the use of alcohol to become disinhibited); he also implemented binge drinking behaviors for self-medicative and antianxiety purposes, which gradually triggered a mechanism of alcohol dependence.
背景:一些研究已经调查了暴露在高海拔地区的短暂和长期神经系统影响以及缺氧对记忆和认知的相关后遗症,但很少有作者讨论高海拔活动中的心理症状问题。这些作者怀疑,精神症状的复发或恶化很可能是对环境条件变化的适应不良行为的表现。病例报告:我们描述了一名有偶发性恐慌发作史的患者的病例,该患者具有恐慌性广场恐惧症(社交恐惧症和分离焦虑症),在青春期的特定社交环境中,他倾向于将酒精滥用于娱乐和去抑制目的,以解决他在社交领域的关系问题。经过多年的禁欲,该患者决定接受高海拔工作,并患上了严重的酒精使用障碍,包括社交和工作方面的功能逐渐恶化。讨论:我们提出,由于每天在工作中都会经历高海拔地区,患者的焦虑水平会急剧上升,但会无意识地自动上升,这与之前在青春期实施的一种复制模式有关(通过社交恐惧症和饮酒来解除抑制);他还出于自我治疗和抗焦虑的目的实施了酗酒行为,这逐渐引发了酒精依赖的机制。
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引用次数: 0
Mania Induced by a Single Dose of Synthetic Cannabinoid 单剂量合成大麻素诱发躁狂
IF 1.1 Q3 Medicine Pub Date : 2020-05-22 DOI: 10.1097/ADT.0000000000000212
A. Ekici, Ş. Şahin, Gülçin Elboğa, A. Altındağ
Synthetic cannabinoids (SCs) are substances with chemical structures that comprise a family of compounds and have structures that can bind to cannabinoid receptors in human cells known as CB1 or CB2. Most SCs are stronger than tetrahydrocannabinol and pose a greater health risk. In this article, we present a mania case that was triggered by a single dose of the SC Bonzai and registered improvement after longterm inpatient treatment. In the literature, only one previous case has been reported of a manic attack induced by SC, and this previously reported case had manic symptoms that started after 6months of SC use. In our case, we aimed to discuss the possible mechanisms of SC use, which may cause affective symptoms and a serious psychotic manic episode even in the absence of long-term exposure.
合成大麻素(SC)是具有化学结构的物质,包括一系列化合物,并且具有可以与人体细胞中的大麻素受体CB1或CB2结合的结构。大多数SC比四氢大麻酚更强,对健康的风险更大。在这篇文章中,我们提出了一个躁狂病例,由单剂量SC邦仔引发,并在长期住院治疗后有所改善。在文献中,只有一例先前报道的SC诱导的躁狂发作病例,该先前报道的病例在使用SC 6个月后开始出现躁狂症状。在我们的案例中,我们旨在讨论SC使用的可能机制,即使在没有长期接触的情况下,SC也可能导致情感症状和严重的精神病性躁狂发作。
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引用次数: 0
The Effectiveness of Ego-state Therapy in Reducing Trypanophobia 自我状态治疗在减少锥虫恐惧症中的有效性
IF 1.1 Q3 Medicine Pub Date : 2020-05-12 DOI: 10.1097/ADT.0000000000000210
D. Daharnis, I. Ifdil, Berru Amalianita, N. Zola, Y. E. Putri
A phobia is an excessive fear of something or a phenomenon. Phobias can be considered to hinder the lives of people who suffer from them, and one of them is trypanophobia, an extreme fear of medical procedures involving injections or hypodermic needles. The symptoms of trypanophobia can greatly disrupt a person’s quality of life, both physically and psychologically. Phobia sufferers cannot heal themselves and so they must be assisted by therapists who are competent in their field. One of the therapeutic techniques that can help cure phobia sufferers is ego-state therapy. This therapy enables the respondents’ underlying states to be allocated to all ego states that contribute to trypanophobia and to be expressed, released, and empowered. The research objective here is to analyze the effectiveness of egostate therapy in reducing trypanophobia. This research uses single-subject design A-B-A-B with 9 medical patients acting as respondents. The instruments used are observation, interview, and the Depression Anxiety Stress Scale Modification Inventory. Data obtained were analyzed used the Wilcoxon signed-rank test. The results of the study found that ego-state therapy can reduce trypanophobia. On the basis of this finding, this therapy can be one alternative treatment in the reduction of trypanophobia.
恐惧症是对某事或现象的过度恐惧。Phobias可以被认为阻碍了患者的生活,其中之一是锥虫恐惧症,这是一种对注射或皮下注射针头的医疗程序的极度恐惧。锥虫恐惧症的症状会极大地扰乱一个人的身体和心理生活质量。恐惧症患者无法治愈自己,因此他们必须得到在自己领域有能力的治疗师的帮助。自我状态疗法是一种可以帮助治愈恐惧症患者的治疗技术。这种疗法使受访者的基本状态能够被分配给所有导致锥虫恐惧症的自我状态,并被表达、释放和赋予权力。本文的研究目的是分析自我状态疗法在减少锥虫恐惧症方面的有效性。本研究采用单受试者设计A-B-A-B,9名医疗患者作为调查对象。使用的工具有观察、访谈和抑郁焦虑压力量表修正量表。使用Wilcoxon符号秩检验对获得的数据进行分析。研究结果发现,自我状态疗法可以减少对锥虫的恐惧。基于这一发现,这种疗法可以成为减少锥虫恐惧症的一种替代疗法。
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引用次数: 0
The Effectiveness of Ego State Therapy in the Reduction of Athletes’ Stress Levels 自我状态治疗在降低运动员应激水平方面的有效性
IF 1.1 Q3 Medicine Pub Date : 2020-05-12 DOI: 10.1097/ADT.0000000000000211
T. H. Sin, I. Ifdil, Berru Amalianita
Stress affects the performance level of professional athletes during training and competition, thereby decreasing their achievements. Using an individual approach, this study aimed to analyze ego state therapy to reduce stress through relaxation. A single-subject design was used to obtain data from 6 athletes with high stress through observation and administration of the Mini Stress Scale. The result showed that this therapy acts as an alternative treatment in reducing stress.
压力会影响职业运动员在训练和比赛中的表现水平,从而降低他们的成绩。本研究采用个体化方法,旨在分析自我状态疗法通过放松来减轻压力。采用单受试者设计,通过迷你压力量表的观察和管理,获得6名高压力运动员的数据。结果表明,这种疗法在减轻压力方面是一种替代疗法。
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引用次数: 0
Naloxone-induced Peripheral Edema: A Case Report 纳洛酮所致外周水肿1例报告
IF 1.1 Q3 Medicine Pub Date : 2020-05-05 DOI: 10.1097/ADT.0000000000000209
S. R. Taylor, B. D. Gustafson, Daniel S. Hough
Introduction: Despite a low bioavailability, sublingual naloxone does reach systemic circulation as evidenced by pharmacokinetic studies. As observed in clinical practice, patients receiving sublingual naloxone in combination with buprenorphine occasionally experience adverse reactions that resolve when naloxone alone is discontinued suggesting potential for naloxone-induced reactions. According to postmarketing data, peripheral edema is one of the most common adverse drug events related to sublingual buprenorphine/ naloxone. Case: A case of potential naloxone-induced peripheral edema in a 69-year-old woman. The patient experienced peripheral edema over the course of several months after the initiation of sublingual buprenorphine/ naloxone despite numerous attempts at pharmacological diuresis. Within 1 month of omitting naloxone from her regimen and continuing buprenorphine monotherapy, the patient’s edema resolved. Conclusions: Given pharmacokinetic studies and evidence of systemic absorption, adverse drug reactions from sublingual naloxone are possible. Mindfulness of appropriate candidates for combination sublingual buprenorphine/naloxone formulations and monitoring for naloxone-induced peripheral edema is prudent.
引言:尽管纳洛酮的生物利用度较低,但药代动力学研究证明,舌下纳洛酮确实能达到全身循环。正如在临床实践中观察到的那样,接受舌下纳洛酮与丁丙诺啡联合治疗的患者偶尔会出现不良反应,当停止单独使用纳洛酮时,不良反应就会消失,这表明纳洛酮可能会引发反应。根据上市后的数据,外周水肿是与舌下丁丙诺啡/纳洛酮相关的最常见的药物不良事件之一。病例:一例69岁女性潜在纳洛酮诱发的外周水肿。尽管多次尝试药物利尿,但患者在开始舌下丁丙诺啡/纳洛酮治疗后的几个月内出现了外周水肿。在她的方案中省略纳洛酮并继续丁丙诺啡单药治疗的1个月内,患者的水肿得到了缓解。结论:鉴于药代动力学研究和全身吸收的证据,舌下纳洛酮可能产生不良药物反应。谨慎选择合适的舌下丁丙诺啡/纳洛酮联合制剂候选药物,并监测纳洛酮诱导的外周水肿。
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引用次数: 1
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