Pub Date : 2022-08-15DOI: 10.18231/j.ijpo.2022.055
Sinchana KM, M. Jadhav, S. Kittur
: The Papanicolaou (Pap) smear used worldwide for cervical screening was developed by Dr George Papanicolaou in 1940s. The Pap smear is a simple, safe and effective test to detect cervical cancer at an early stage.: To study the spectrum of lesions in cervical Pap smear based on The Bethesda System(TBS) 2014 and to determine frequency of premalignant and malignant lesions.: The present prospective study included 200 cases above 20 years of age. The cytological interpretation of smears were made according to TBS 2014. When there was difficulty in differentiating HSIL from other lesions p16 immunostaining was done and evaluated according to the criteria proposed by Wentzensen et al. : Chi – square test was used to see the association between different attributes. Statistical analysis was performed using SPSS version 22. P value <0.05 was considered significant.: The most common lesion was NILM with 175 cases (87.5%) followed by 7(3.5%) SCC, 4(2%) HSIL, 2(1%) cases each of ASCUS, AGC-NOS, LSIL and 1(0.5%) case of ASC-H. Among 200, 7(3.5%) cases were unsatisfactory for evaluation. The subjects were not uniformly distributed (P <0.001). The p16 marker was used in 6(3%) doubtful cases of HSIL among which 2(33.33%) cases were positive. Cervical Pap smear is a useful technique to detect the inflammatory, premalignant and malignant lesions of cervix which helps the clinician to plan further management.
{"title":"Cytomorphological study of cervical Pap smear based on the Bethesda system 2014","authors":"Sinchana KM, M. Jadhav, S. Kittur","doi":"10.18231/j.ijpo.2022.055","DOIUrl":"https://doi.org/10.18231/j.ijpo.2022.055","url":null,"abstract":": The Papanicolaou (Pap) smear used worldwide for cervical screening was developed by Dr George Papanicolaou in 1940s. The Pap smear is a simple, safe and effective test to detect cervical cancer at an early stage.: To study the spectrum of lesions in cervical Pap smear based on The Bethesda System(TBS) 2014 and to determine frequency of premalignant and malignant lesions.: The present prospective study included 200 cases above 20 years of age. The cytological interpretation of smears were made according to TBS 2014. When there was difficulty in differentiating HSIL from other lesions p16 immunostaining was done and evaluated according to the criteria proposed by Wentzensen et al. : Chi – square test was used to see the association between different attributes. Statistical analysis was performed using SPSS version 22. P value <0.05 was considered significant.: The most common lesion was NILM with 175 cases (87.5%) followed by 7(3.5%) SCC, 4(2%) HSIL, 2(1%) cases each of ASCUS, AGC-NOS, LSIL and 1(0.5%) case of ASC-H. Among 200, 7(3.5%) cases were unsatisfactory for evaluation. The subjects were not uniformly distributed (P <0.001). The p16 marker was used in 6(3%) doubtful cases of HSIL among which 2(33.33%) cases were positive. Cervical Pap smear is a useful technique to detect the inflammatory, premalignant and malignant lesions of cervix which helps the clinician to plan further management.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122590240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-15DOI: 10.18231/j.ijpo.2022.057
M Vijayalakshmi, Sharmila Thilagavathy N, Rani K
Many research studies on various biomarkers were done, in analysing the prognosis and in evaluation of therapeutic target strategies which improves the survival rate in carcinoma of cervix. Of these, one of the important biomarker is HER-2/neu. To correlate histomorphology of cervical lesions, various clinicopathological parameters with HER-2/neu. The present study conducted during the period from June 2017 to May 2019 in department of Pathology, Madurai Medical College, Madurai. 200 cases were selected for study. Among those, 50 cases were selected for immunohistochemical studies with HER 2. Out of 50 cases included, higher HER 2 positivity was observed in HSIL as compared to LSIL. In malignant lesions, positive immunostaining was observed in 71.05% cases. Positivity was seen in 70% of cases of squamous cell carcinoma and 75% of cases of adenocarcinoma cases. Progression of clinical spectrum of the lesion is associated with overexpression if HER 2, suggesting HER 2 can be considered as one of poor prognostic factor. Malignant lesions expressed greater positivity than premalignant lesions. Also, overexpression of HER 2 is associated with progressing grade and advanced stage of cervical carcinoma.
{"title":"Role of HER2/neu expression in premalignant and malignant lesions of uterine cervix","authors":"M Vijayalakshmi, Sharmila Thilagavathy N, Rani K","doi":"10.18231/j.ijpo.2022.057","DOIUrl":"https://doi.org/10.18231/j.ijpo.2022.057","url":null,"abstract":"Many research studies on various biomarkers were done, in analysing the prognosis and in evaluation of therapeutic target strategies which improves the survival rate in carcinoma of cervix. Of these, one of the important biomarker is HER-2/neu. To correlate histomorphology of cervical lesions, various clinicopathological parameters with HER-2/neu. The present study conducted during the period from June 2017 to May 2019 in department of Pathology, Madurai Medical College, Madurai. 200 cases were selected for study. Among those, 50 cases were selected for immunohistochemical studies with HER 2. Out of 50 cases included, higher HER 2 positivity was observed in HSIL as compared to LSIL. In malignant lesions, positive immunostaining was observed in 71.05% cases. Positivity was seen in 70% of cases of squamous cell carcinoma and 75% of cases of adenocarcinoma cases. Progression of clinical spectrum of the lesion is associated with overexpression if HER 2, suggesting HER 2 can be considered as one of poor prognostic factor. Malignant lesions expressed greater positivity than premalignant lesions. Also, overexpression of HER 2 is associated with progressing grade and advanced stage of cervical carcinoma.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125251191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-15DOI: 10.18231/j.ijpo.2022.054
Aarti Tyagi, S. Grover, R. Bansal
The Corona virus poses a greater challenge in the form of the deadly fungal infection, mucormycosis. To study the histopathological features giving emphasis on the varying presentation of mucormycosis in sequential covid waves.A prospective study comprising 31 patients histopathologically diagnosed with mucormycosis were included in the study. Demographic features, predisposing conditions, and clinical features were obtained from medical records. Tissue sections were reviewed with hematoxylin and eosin (H and E), and special stains like Gomori's methenamine silver (GMS), and periodic acid Schiff (PAS) potassium hydroxide (KOH) examination and fungal culture. The study included 21 males and 10 females with age ranging from 35-75 years. On histopathological examination, inflammation, granulomas, foreign body giant cells along with necrosis was seen. Invasion into soft tissues, muscles, and adipose tissues along with Angioinvasion, perineural spread was identified. Fungal balls, round to ovoid mature sporangia with column-shaped columella, presence of proliferating hyphae in tissues like skeletal muscle, cartilage etc which are supposed to be relatively resistant for inflammatory pathology got noted as one of our astounded histopathological findings insinuating how a human body acts as a culture media exhibiting diversity of a human makeup. The trend of presentation and severity kept changing with successive covid wave. Diagnosis of mucormycosis is gruesome and more difficult as compared to other infectious organism. In addition, like any malignant pathology, perivascular and neural infiltration is one of the important histological features of invasive mucormycosis as it indicates the severity and prognosis. There is drastically different trend of presentation in covid and its different mutant waves.
{"title":"Changing faces and habitat of mucormycosis epidemic in sequential COVID waves","authors":"Aarti Tyagi, S. Grover, R. Bansal","doi":"10.18231/j.ijpo.2022.054","DOIUrl":"https://doi.org/10.18231/j.ijpo.2022.054","url":null,"abstract":"The Corona virus poses a greater challenge in the form of the deadly fungal infection, mucormycosis. To study the histopathological features giving emphasis on the varying presentation of mucormycosis in sequential covid waves.A prospective study comprising 31 patients histopathologically diagnosed with mucormycosis were included in the study. Demographic features, predisposing conditions, and clinical features were obtained from medical records. Tissue sections were reviewed with hematoxylin and eosin (H and E), and special stains like Gomori's methenamine silver (GMS), and periodic acid Schiff (PAS) potassium hydroxide (KOH) examination and fungal culture. The study included 21 males and 10 females with age ranging from 35-75 years. On histopathological examination, inflammation, granulomas, foreign body giant cells along with necrosis was seen. Invasion into soft tissues, muscles, and adipose tissues along with Angioinvasion, perineural spread was identified. Fungal balls, round to ovoid mature sporangia with column-shaped columella, presence of proliferating hyphae in tissues like skeletal muscle, cartilage etc which are supposed to be relatively resistant for inflammatory pathology got noted as one of our astounded histopathological findings insinuating how a human body acts as a culture media exhibiting diversity of a human makeup. The trend of presentation and severity kept changing with successive covid wave. Diagnosis of mucormycosis is gruesome and more difficult as compared to other infectious organism. In addition, like any malignant pathology, perivascular and neural infiltration is one of the important histological features of invasive mucormycosis as it indicates the severity and prognosis. There is drastically different trend of presentation in covid and its different mutant waves.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127054489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-15DOI: 10.18231/j.ijpo.2022.058
Ketki Kelkar, Siddharth Anand, Nikita Somani, Vijay Ramanan, S. Ranade, Kunal Patil, Trupti Ragte-Wathare, Priyanka V. Gangodkar, K. Khatod, M. Agarwal
Myeloproliferative neoplasms (MPNs) are caused by somatic pathogenic variants that stimulate increased production and clonal expansion of CD34 multipotent hematopoietic stem cells. Recent World Health Organization (WHO) diagnostic criteria for the diagnosis of Philadelphia chromosome (Ph) negative MPNs includes detection of mutations in the Janus Kinase 2 (), myeloproliferative leukemia (), and calreticulin () genes. The purpose of this study was to demonstrate the clinical utility of an in-house next-generation sequencing (NGS) assay targeting only these canonical genes for the molecular diagnosis of patients with Ph-negative MPNs. We tested 274 samples of patients clinically suspected of having Ph-negative MPNs using an in-house developed NGS panel. The assay consists of two parts, a multiplexed PCR and a highly multiplexed NGS workflow capable of handling diverse samples. The assay is capable of simultaneously detecting mutations in exons 12 and 14, exon 9, and exon 10. Of the 274 samples tested, 49 samples harbored mutations in the gene (48 for the V617F and 1 for exon 12), 31 harbored mutations in the gene, and two harbored mutations in the gene. One sample harbored a mutation each in the and genes. Here, we present the distribution of mutations in an Indian cohort of 274 patients from India with Ph-negative MPNs. Moreover, we have successfully demonstrated the clinical utility of our in-house multiplexed NGS assay for the molecular diagnosis of MPNs with varying mutation depths
{"title":"Targeted NGS analysis of the canonical genes in 274 Indian patients with suspected myeloproliferative neoplasms: An Indian diagnostic laboratory’s perspective","authors":"Ketki Kelkar, Siddharth Anand, Nikita Somani, Vijay Ramanan, S. Ranade, Kunal Patil, Trupti Ragte-Wathare, Priyanka V. Gangodkar, K. Khatod, M. Agarwal","doi":"10.18231/j.ijpo.2022.058","DOIUrl":"https://doi.org/10.18231/j.ijpo.2022.058","url":null,"abstract":"Myeloproliferative neoplasms (MPNs) are caused by somatic pathogenic variants that stimulate increased production and clonal expansion of CD34 multipotent hematopoietic stem cells. Recent World Health Organization (WHO) diagnostic criteria for the diagnosis of Philadelphia chromosome (Ph) negative MPNs includes detection of mutations in the Janus Kinase 2 (), myeloproliferative leukemia (), and calreticulin () genes. The purpose of this study was to demonstrate the clinical utility of an in-house next-generation sequencing (NGS) assay targeting only these canonical genes for the molecular diagnosis of patients with Ph-negative MPNs. We tested 274 samples of patients clinically suspected of having Ph-negative MPNs using an in-house developed NGS panel. The assay consists of two parts, a multiplexed PCR and a highly multiplexed NGS workflow capable of handling diverse samples. The assay is capable of simultaneously detecting mutations in exons 12 and 14, exon 9, and exon 10. Of the 274 samples tested, 49 samples harbored mutations in the gene (48 for the V617F and 1 for exon 12), 31 harbored mutations in the gene, and two harbored mutations in the gene. One sample harbored a mutation each in the and genes. Here, we present the distribution of mutations in an Indian cohort of 274 patients from India with Ph-negative MPNs. Moreover, we have successfully demonstrated the clinical utility of our in-house multiplexed NGS assay for the molecular diagnosis of MPNs with varying mutation depths","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133978728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-15DOI: 10.18231/j.ijpo.2022.063
Ankit Gupta, M. Kalloli, R. Patil, Chenchulakshmi Vasudevan, Sanjiti Madan
Recently developing countries showing growing trend in hepatocellular carcinoma cases. Hepatocellular carcinoma metastasis to oral cavity is uncommon finding. Most common site for mets is lung, breast, kidney. Data on HCC metastasis to oral cavity is limited. We present here one such rare case of HCC metastasis to oral cavity. Awareness about the entity helps in early diagnosis and management that leads to better prognosis and good quality of life to patient.
{"title":"A unique case of HCC presenting as oral cancer","authors":"Ankit Gupta, M. Kalloli, R. Patil, Chenchulakshmi Vasudevan, Sanjiti Madan","doi":"10.18231/j.ijpo.2022.063","DOIUrl":"https://doi.org/10.18231/j.ijpo.2022.063","url":null,"abstract":"Recently developing countries showing growing trend in hepatocellular carcinoma cases. Hepatocellular carcinoma metastasis to oral cavity is uncommon finding. Most common site for mets is lung, breast, kidney. Data on HCC metastasis to oral cavity is limited. We present here one such rare case of HCC metastasis to oral cavity. Awareness about the entity helps in early diagnosis and management that leads to better prognosis and good quality of life to patient.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132213091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-15DOI: 10.18231/j.ijpo.2022.067
Shruthi Panduranga, Harisha V
Chronic sclerosing sialadenitis also known as ‘Küttner’s tumour’ (KT) is a benign chronic inflammatory condition first described by Küttner, clinically presenting as a firm swelling, often simulating a neoplasm. The condition is usually misrecognised and the correct diagnosis is made after the excision of the gland. Recent evidence suggests that Küttner’s tumor may be characterized by IgG4-related inflammation. An accurate preoperative diagnosis can be made by awareness of the condition, imaging and histopathopathology features, thereby potentially avoiding excision of an otherwise benign condition. Küttner’s tumour most commonly affects submandibular gland. Küttner’s tumour of the parotid and minor salivary glands are extremely rare. We report a case of a 69 year old man with this interesting and uncommon entity affecting the parotid gland.
{"title":"Küttner’s tumour of the parotid gland- an uncommon entity","authors":"Shruthi Panduranga, Harisha V","doi":"10.18231/j.ijpo.2022.067","DOIUrl":"https://doi.org/10.18231/j.ijpo.2022.067","url":null,"abstract":"Chronic sclerosing sialadenitis also known as ‘Küttner’s tumour’ (KT) is a benign chronic inflammatory condition first described by Küttner, clinically presenting as a firm swelling, often simulating a neoplasm. The condition is usually misrecognised and the correct diagnosis is made after the excision of the gland. Recent evidence suggests that Küttner’s tumor may be characterized by IgG4-related inflammation. An accurate preoperative diagnosis can be made by awareness of the condition, imaging and histopathopathology features, thereby potentially avoiding excision of an otherwise benign condition. Küttner’s tumour most commonly affects submandibular gland. Küttner’s tumour of the parotid and minor salivary glands are extremely rare. We report a case of a 69 year old man with this interesting and uncommon entity affecting the parotid gland.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125790941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-15DOI: 10.18231/j.ijpo.2022.066
Jaydeep N Pol, Vaishali J Pol, Pradipta Patil
Osseous choristoma is the formation of normal mature bone at an abnormal position. These are rare benign tumor-like growth usually asymptomatic except growth or swelling as the clinical presentation. In oral cavity, osseous choristoma is rare and commonly found in posterior third of the tongue. Clinically it is misdiagnosed as malignancy because of its hardness. Clinically, it is also mistaken for other oral cavity lesions, especially those of minor salivary gland lesions of oral cavity. Hence, awareness amongst clinicians, general practitioners and oral pathologists about oral osseous choristomas is necessary. Here, we report two cases of osseous choristoma in the oral cavity located at sites other than tongue.
{"title":"Osseous choristoma: Report of two cases in oral cavity","authors":"Jaydeep N Pol, Vaishali J Pol, Pradipta Patil","doi":"10.18231/j.ijpo.2022.066","DOIUrl":"https://doi.org/10.18231/j.ijpo.2022.066","url":null,"abstract":"Osseous choristoma is the formation of normal mature bone at an abnormal position. These are rare benign tumor-like growth usually asymptomatic except growth or swelling as the clinical presentation. In oral cavity, osseous choristoma is rare and commonly found in posterior third of the tongue. Clinically it is misdiagnosed as malignancy because of its hardness. Clinically, it is also mistaken for other oral cavity lesions, especially those of minor salivary gland lesions of oral cavity. Hence, awareness amongst clinicians, general practitioners and oral pathologists about oral osseous choristomas is necessary. Here, we report two cases of osseous choristoma in the oral cavity located at sites other than tongue.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131045485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-15DOI: 10.18231/j.ijpo.2022.062
K. Aboud, A. Malki, Hasan Al Solami, Nasser Idrees
This is a concise case report about the observation of an old patient with perianal skin tag found on pathological examination to be a melanocytic nevus.
这是一个简明的病例报告，观察一个老年患者的肛周皮赘在病理检查发现为黑素细胞痣。
{"title":"Melanocytic nevus presenting as perianal skin tag","authors":"K. Aboud, A. Malki, Hasan Al Solami, Nasser Idrees","doi":"10.18231/j.ijpo.2022.062","DOIUrl":"https://doi.org/10.18231/j.ijpo.2022.062","url":null,"abstract":"This is a concise case report about the observation of an old patient with perianal skin tag found on pathological examination to be a melanocytic nevus.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127158614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-15DOI: 10.18231/j.ijpo.2022.050
Cancers of unknown primary site (CUPs) are histologically confirmed metastatic carcinoma for which primary site cannot be identified after standard diagnostic approach. It comprises 3-4% of all malignant neoplasms. The broad tumour type for CUPs is carcinoma. Metastatic tumours are more difficult to classify than primaries by Immunohistochemistry (IHC). Integration of morphology & IHC is the gold standard at diagnosing CUP. It is important to be aware of possible pitfalls of IHC and pay attention to correct interpretation. One should have a working algorithmic approach to identifying and classifying CUPs.
{"title":"Algorithmic approach of immunohistochemistry in metastatic carcinoma of unknown primary site","authors":"","doi":"10.18231/j.ijpo.2022.050","DOIUrl":"https://doi.org/10.18231/j.ijpo.2022.050","url":null,"abstract":"Cancers of unknown primary site (CUPs) are histologically confirmed metastatic carcinoma for which primary site cannot be identified after standard diagnostic approach. It comprises 3-4% of all malignant neoplasms. The broad tumour type for CUPs is carcinoma. Metastatic tumours are more difficult to classify than primaries by Immunohistochemistry (IHC). Integration of morphology & IHC is the gold standard at diagnosing CUP. It is important to be aware of possible pitfalls of IHC and pay attention to correct interpretation. One should have a working algorithmic approach to identifying and classifying CUPs.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"147 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124715145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-15DOI: 10.18231/j.ijpo.2022.064
Srinidhi R, V. Ramaswamy, Tejaswini B N, Sowmya B U
Adenoma malignum also called minimal deviation adenocarcinoma or minimal deviation carcinoma, is a rare disease. It is tricky to diagnose this condition because of its benign look. It forms a subtype of mucinous endocervical adenocarcinoma. Also, these lesions have an endophytic growth and are located deep in the cervix rather than an exophytic growth like any other adenocarcinoma of the cervix. Radiologically and clinically can resemble a benign, less harmful disease. However, it sometimes mimics multiple Nabothian cysts because of its benign look. In most cases, it had been an incidental finding when being evaluated for any other causes where hysterectomy was done. It usually presents between the age of 25-70 years and peaks at a median age of 42 years. Thus, this case report is an eye opener to keep Adenoma malignum is a close differential for watery discharge per vaginum. Although it is a rare tumour, it has an aggressive nature.
{"title":"Adenoma malignum of cervix – A case report","authors":"Srinidhi R, V. Ramaswamy, Tejaswini B N, Sowmya B U","doi":"10.18231/j.ijpo.2022.064","DOIUrl":"https://doi.org/10.18231/j.ijpo.2022.064","url":null,"abstract":"Adenoma malignum also called minimal deviation adenocarcinoma or minimal deviation carcinoma, is a rare disease. It is tricky to diagnose this condition because of its benign look. It forms a subtype of mucinous endocervical adenocarcinoma. Also, these lesions have an endophytic growth and are located deep in the cervix rather than an exophytic growth like any other adenocarcinoma of the cervix. Radiologically and clinically can resemble a benign, less harmful disease. However, it sometimes mimics multiple Nabothian cysts because of its benign look. In most cases, it had been an incidental finding when being evaluated for any other causes where hysterectomy was done. It usually presents between the age of 25-70 years and peaks at a median age of 42 years. Thus, this case report is an eye opener to keep Adenoma malignum is a close differential for watery discharge per vaginum. Although it is a rare tumour, it has an aggressive nature.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124853582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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