Pub Date : 2022-05-15DOI: 10.18231/j.ijpo.2022.027
Himanshu Sharma, Dayal Singh Bisht, Devang Sharma, V. Upadhyay
A retrospective study was conducted in a tertiary care hospital in which the cytological diagnosis of palpable lesion of breast was compared with histopathological diagnosis to see the accuracy of cytology for both benign and neoplastic lumps in breast. A total number of 101 fine needle aspiration cytology was performed over a period of two years in cases of breast lump. The cytological and histological correlation was found in 51 cases (50%) out of 101cases. The commonest benign lesion was fibroadenoma, which was noted in age group of 15-35 years and the commonst malignant lesion was infiltrating ductal carcinoma, which was noted in the age group of 50-70 years. Thus the present study revealed that FNAC had Sensitivity of 50%, Specificity of 100%, Positive predictive value 100%, Negative predictive value 95.9% and the overall accuracy of the study was 96.1%.
{"title":"To compare the diagnostic accuracy of FNAC with histopathology in benign and malignant breast lumps","authors":"Himanshu Sharma, Dayal Singh Bisht, Devang Sharma, V. Upadhyay","doi":"10.18231/j.ijpo.2022.027","DOIUrl":"https://doi.org/10.18231/j.ijpo.2022.027","url":null,"abstract":"A retrospective study was conducted in a tertiary care hospital in which the cytological diagnosis of palpable lesion of breast was compared with histopathological diagnosis to see the accuracy of cytology for both benign and neoplastic lumps in breast. A total number of 101 fine needle aspiration cytology was performed over a period of two years in cases of breast lump. The cytological and histological correlation was found in 51 cases (50%) out of 101cases. The commonest benign lesion was fibroadenoma, which was noted in age group of 15-35 years and the commonst malignant lesion was infiltrating ductal carcinoma, which was noted in the age group of 50-70 years. Thus the present study revealed that FNAC had Sensitivity of 50%, Specificity of 100%, Positive predictive value 100%, Negative predictive value 95.9% and the overall accuracy of the study was 96.1%.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124838732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-15DOI: 10.18231/j.ijpo.2022.032
M. Thokal, M. Kulkarni, S. Sidhewad, A. Gosavi
The sinonasal tract is exposed to a variety of infections, chemical irritants, antigens and trauma giving rise to diverse inflammatory as well as neoplastic lesions. The aim was to study the clinicopathological profile of lesions of nose and paranasal sinuses in this area of western Maharashtra. The study included 59 biopsies/resection specimens received in the department during Jan 2015 to June 2019. Clinical and pathological details were analysed. There were 33 females and 26 males. Out of 59 cases, 46 were nonneoplastic and 13 neoplastic, with 10 benign and three malignant. The most common nonneoplastic lesion was sinonasal polyp (42 cases). Other nonneoplastic lesions included three cases of mucormycosis and one case of rhinosporidiosis. In the benign neoplasms, there were three cases of hemangiomas, two hamartomas, two inverted papillomas with one case each of hidradenoma, angiofibroma and schwannoma. We had three malignant tumors, one case each of, melanoma, poorly differentiated carcinoma and squammous cell carcinoma. Nonneoplastic lesions were much more common than neoplastic ones in the sinonasal tract. Histopathological examination plays an important role in correct diagnosis and management.
{"title":"Clinicopathological analysis of sinonasal lesions","authors":"M. Thokal, M. Kulkarni, S. Sidhewad, A. Gosavi","doi":"10.18231/j.ijpo.2022.032","DOIUrl":"https://doi.org/10.18231/j.ijpo.2022.032","url":null,"abstract":"The sinonasal tract is exposed to a variety of infections, chemical irritants, antigens and trauma giving rise to diverse inflammatory as well as neoplastic lesions. The aim was to study the clinicopathological profile of lesions of nose and paranasal sinuses in this area of western Maharashtra. The study included 59 biopsies/resection specimens received in the department during Jan 2015 to June 2019. Clinical and pathological details were analysed. There were 33 females and 26 males. Out of 59 cases, 46 were nonneoplastic and 13 neoplastic, with 10 benign and three malignant. The most common nonneoplastic lesion was sinonasal polyp (42 cases). Other nonneoplastic lesions included three cases of mucormycosis and one case of rhinosporidiosis. In the benign neoplasms, there were three cases of hemangiomas, two hamartomas, two inverted papillomas with one case each of hidradenoma, angiofibroma and schwannoma. We had three malignant tumors, one case each of, melanoma, poorly differentiated carcinoma and squammous cell carcinoma. Nonneoplastic lesions were much more common than neoplastic ones in the sinonasal tract. Histopathological examination plays an important role in correct diagnosis and management.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"94 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127066236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-15DOI: 10.18231/j.ijpo.2022.026
Bhanushree C S
{"title":"Cancer registry: A boon for world","authors":"Bhanushree C S","doi":"10.18231/j.ijpo.2022.026","DOIUrl":"https://doi.org/10.18231/j.ijpo.2022.026","url":null,"abstract":"","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"86 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126932660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-15DOI: 10.18231/j.ijpo.2022.036
Saqib Ahmed, Hena A. Ansari, K. Rajput
The ectopic Salivary Gland is the presence of salivary tissue in unusual locations which do not normally host it. Moreover, neoplasms arising from these ectopic tissues are very rare, however, tumourigenic changes in these inclusions have been observed in a few cases.We present a clinically unsuspected case of an ectopic salivary gland tissue present on the mid-neck, which was diagnosed as Small lymphocytic leukaemia outside Jawaharlal Nehru Medical College, Aligarh. On further evaluation, a definitive diagnosis of epithelial myoepithelial carcinoma arising in ectopic salivary gland tissue within the cervical lymph node was made. Therefore, these tumours need to be included in the differential diagnosis of neck masses, for a prompt diagnosis and adequate treatment.
{"title":"Epithelial myoepithelial carcinoma in an ectopic salivary gland: A diagnostic dilemma","authors":"Saqib Ahmed, Hena A. Ansari, K. Rajput","doi":"10.18231/j.ijpo.2022.036","DOIUrl":"https://doi.org/10.18231/j.ijpo.2022.036","url":null,"abstract":"The ectopic Salivary Gland is the presence of salivary tissue in unusual locations which do not normally host it. Moreover, neoplasms arising from these ectopic tissues are very rare, however, tumourigenic changes in these inclusions have been observed in a few cases.We present a clinically unsuspected case of an ectopic salivary gland tissue present on the mid-neck, which was diagnosed as Small lymphocytic leukaemia outside Jawaharlal Nehru Medical College, Aligarh. On further evaluation, a definitive diagnosis of epithelial myoepithelial carcinoma arising in ectopic salivary gland tissue within the cervical lymph node was made. Therefore, these tumours need to be included in the differential diagnosis of neck masses, for a prompt diagnosis and adequate treatment.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132743318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-15DOI: 10.18231/j.ijpo.2022.049
Iffat Jamal
{"title":"A diagnostic and therapeutic conflict with masked megaloblastosis","authors":"Iffat Jamal","doi":"10.18231/j.ijpo.2022.049","DOIUrl":"https://doi.org/10.18231/j.ijpo.2022.049","url":null,"abstract":"","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114197742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-15DOI: 10.18231/j.ijpo.2022.028
Syeda Sarah Mahjabeen, Rania Musa, Rehab Salah, M. Baig, Swamy K
Blood smear is considered as the gold standard test to diagnose Malaria parasite. The newer RDTs (malaria antigen) are reported to be highly sensitive, specific and time saving as compared to other diagnostic modalities. This test is undertaken to compare the efficacy of PfHRP-2 tests, PLDH and manual technique. A total of 252 cases of malaria as diagnosed by Composite reference techniquewere studied. The sensitivity of TFM, RDTs and PCR is 71.5%, 84.3% and 82.6% respectively and the specificity is 81.9%, 77.2% and 78.2% respectively.: The fact that the PCR & RDTs are costly, cannot assess the response of patients to treatment and inability to assess parasitic stage and density, makes the old dictum “Blood smears are the gold standard for the diagnosis of Malaria” to still hold truth.
{"title":"Comparative analysis of the diagnostic accuracy of malaria parasite by microscopy, RDTs (PfHRP-2 & PLDH) and PCR","authors":"Syeda Sarah Mahjabeen, Rania Musa, Rehab Salah, M. Baig, Swamy K","doi":"10.18231/j.ijpo.2022.028","DOIUrl":"https://doi.org/10.18231/j.ijpo.2022.028","url":null,"abstract":"Blood smear is considered as the gold standard test to diagnose Malaria parasite. The newer RDTs (malaria antigen) are reported to be highly sensitive, specific and time saving as compared to other diagnostic modalities. This test is undertaken to compare the efficacy of PfHRP-2 tests, PLDH and manual technique. A total of 252 cases of malaria as diagnosed by Composite reference techniquewere studied. The sensitivity of TFM, RDTs and PCR is 71.5%, 84.3% and 82.6% respectively and the specificity is 81.9%, 77.2% and 78.2% respectively.: The fact that the PCR & RDTs are costly, cannot assess the response of patients to treatment and inability to assess parasitic stage and density, makes the old dictum “Blood smears are the gold standard for the diagnosis of Malaria” to still hold truth.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"145 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117075928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-15DOI: 10.18231/j.ijpo.2022.030
Rary P. Mony, Lakshmi K, R. Sukumaran, N. Nayak
The classification of neuroendocrine neoplasms has evolved substantially over time but remains a topic of controversy and debate. Cytology has become one of the mainstays of diagnosis for these tumors, and the treatment may be entirely based on the FNA report.: This is a retrospective study which aims to describe the cytological features found in different groups of Neuroendocrine neoplasms. We have also tried to enumerate the not so typical features which we have seen in our cases. Cases of Neuroendocrine neoplasms diagnosed by cytology in the year 2018 were included in this study. The slides of these cases were retrieved, cytological features reviewed, and clinicopathological features evaluated. Histopathological correlation was done wherever possible. In this retrospective study, there were 43 cases which included FNA (n=38), Fluid cytology(n=3), Bronchial washings and Brushings(n=2). FNA sites included lung, cervical lymph nodes, scalp, liver, pancreas, and mesentery with the cytological diagnoses of Small cell carcinoma (n=22) Neuroendocrine tumor (n=7), Large cell Neuroendocrine carcinoma (n=3) and Poorly differentiated carcinoma with neuroendocrine features (n=11). Features that are of help include scanty cytoplasm, fine or coarse granular chromatin, nuclear moulding and streaking, cells adhering to vessels, inconspicuous nucleoli, nuclear debris in small cell carcinomas; larger cell size, a moderate amount of cytoplasm, coarse granular chromatin in large cell neuroendocrine carcinomas; uniformity of cell size, round to plasmacytoid cells with stippled chromatin and rosette formation in carcinoid tumors. The identification of neuroendocrine morphology in cytology specimens is crucial as this would be the initial step towards using the appropriate markers for confirmation, which in turn has got therapeutic and prognostic significance.
{"title":"Cytologic diagnosis of neuroendocrine neoplasms including carcinoid tumours- A retrospective study","authors":"Rary P. Mony, Lakshmi K, R. Sukumaran, N. Nayak","doi":"10.18231/j.ijpo.2022.030","DOIUrl":"https://doi.org/10.18231/j.ijpo.2022.030","url":null,"abstract":"The classification of neuroendocrine neoplasms has evolved substantially over time but remains a topic of controversy and debate. Cytology has become one of the mainstays of diagnosis for these tumors, and the treatment may be entirely based on the FNA report.: This is a retrospective study which aims to describe the cytological features found in different groups of Neuroendocrine neoplasms. We have also tried to enumerate the not so typical features which we have seen in our cases. Cases of Neuroendocrine neoplasms diagnosed by cytology in the year 2018 were included in this study. The slides of these cases were retrieved, cytological features reviewed, and clinicopathological features evaluated. Histopathological correlation was done wherever possible. In this retrospective study, there were 43 cases which included FNA (n=38), Fluid cytology(n=3), Bronchial washings and Brushings(n=2). FNA sites included lung, cervical lymph nodes, scalp, liver, pancreas, and mesentery with the cytological diagnoses of Small cell carcinoma (n=22) Neuroendocrine tumor (n=7), Large cell Neuroendocrine carcinoma (n=3) and Poorly differentiated carcinoma with neuroendocrine features (n=11). Features that are of help include scanty cytoplasm, fine or coarse granular chromatin, nuclear moulding and streaking, cells adhering to vessels, inconspicuous nucleoli, nuclear debris in small cell carcinomas; larger cell size, a moderate amount of cytoplasm, coarse granular chromatin in large cell neuroendocrine carcinomas; uniformity of cell size, round to plasmacytoid cells with stippled chromatin and rosette formation in carcinoid tumors. The identification of neuroendocrine morphology in cytology specimens is crucial as this would be the initial step towards using the appropriate markers for confirmation, which in turn has got therapeutic and prognostic significance.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116649638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-15DOI: 10.18231/j.ijpo.2022.031
Sunilkumar S Biradar, Pampareddy B. Kollur, Raghunandana R, Girish M Desai, Netravati B Sajjan
Ischemic health disease is a major health and a modern epidemic which is increasing in India. Dyslipidemia is a major risk factor for atherosclerosis. Serum adenosine deaminase activity is associated with coronary artery disease.The present work was done to understand the relation of serum adenosine deaminase activity with dyslipidemia in ischaemic heart disease.This cross-sectional study comprised 200 subjects; healthy and myocardial infarction. Serum ADA and lipids were estimated. Obtained data was statistically analysed.Increase in serum ADA activity correlating with dyslipidemia was found in Myocardial infarction subjects.Increased ADA has role in LDL oxidation, dyslipidemia, foam cell transformation etc. leading to atherosclerosis and ischemic heart disease. Adenosine deaminase has a crucial role in the evolution of ischemic heart disease through dyslipidemia and coronary artery disease.
{"title":"Evaluation of serum adenosine deaminase activity with reference to dyslipidemia in ischemic heart disease","authors":"Sunilkumar S Biradar, Pampareddy B. Kollur, Raghunandana R, Girish M Desai, Netravati B Sajjan","doi":"10.18231/j.ijpo.2022.031","DOIUrl":"https://doi.org/10.18231/j.ijpo.2022.031","url":null,"abstract":"Ischemic health disease is a major health and a modern epidemic which is increasing in India. Dyslipidemia is a major risk factor for atherosclerosis. Serum adenosine deaminase activity is associated with coronary artery disease.The present work was done to understand the relation of serum adenosine deaminase activity with dyslipidemia in ischaemic heart disease.This cross-sectional study comprised 200 subjects; healthy and myocardial infarction. Serum ADA and lipids were estimated. Obtained data was statistically analysed.Increase in serum ADA activity correlating with dyslipidemia was found in Myocardial infarction subjects.Increased ADA has role in LDL oxidation, dyslipidemia, foam cell transformation etc. leading to atherosclerosis and ischemic heart disease. Adenosine deaminase has a crucial role in the evolution of ischemic heart disease through dyslipidemia and coronary artery disease.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128938486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-15DOI: 10.18231/j.ijpo.2022.045
B. Srinivasamurthy, Soundarya Senthilarasu, Sabita Pulavarthi, R. Bhat
Strumaovarii, monodermal ovarian teratoma with incidence of 0.3%. Complications of struma ovarii includes torsion, rupture, infection and malignant transformation. We present you a unusual case of struma ovarii undergoing torsion without any clinical features of thyrotoxicosis in a 45year old postmenopausal women presented with lower abdominal pain and vomiting. Imaging study showed Right ovarian cyst and her thyroid function test, tumor markers(Ca-125, Ca 19-9) are within normal limits. It was histopathologically proven as Torsion struma ovarii. A solid cystic ovarian tumour diagnosed as Struma ovarii undergoing torsion as a complication.Even though struma ovarii is a rare ovarian tumor, we should keep in mind the complications which can happen with this type of tumor including the malignant transformations.
{"title":"The struma with a twist: an uncommon case report","authors":"B. Srinivasamurthy, Soundarya Senthilarasu, Sabita Pulavarthi, R. Bhat","doi":"10.18231/j.ijpo.2022.045","DOIUrl":"https://doi.org/10.18231/j.ijpo.2022.045","url":null,"abstract":"Strumaovarii, monodermal ovarian teratoma with incidence of 0.3%. Complications of struma ovarii includes torsion, rupture, infection and malignant transformation. We present you a unusual case of struma ovarii undergoing torsion without any clinical features of thyrotoxicosis in a 45year old postmenopausal women presented with lower abdominal pain and vomiting. Imaging study showed Right ovarian cyst and her thyroid function test, tumor markers(Ca-125, Ca 19-9) are within normal limits. It was histopathologically proven as Torsion struma ovarii. A solid cystic ovarian tumour diagnosed as Struma ovarii undergoing torsion as a complication.Even though struma ovarii is a rare ovarian tumor, we should keep in mind the complications which can happen with this type of tumor including the malignant transformations.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115987481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-15DOI: 10.18231/j.ijpo.2022.033
Jahnavi Gandhi, Karthik Dhandapani, Brindha Chandithamar, Amisha J. Gami, Ashini Shah, P. Trivedi, K. Puj
Axillary lymph-node (ALN) involvement is an important prognostic factor in patients with breast carcinoma. Evaluation of Sentinel Lymph-nodes (SLN) is an accurate procedure for its assessment in the clinically node negative cases. Frozen Section Evaluation (FSE) is more widely used for intra operative evaluation of SLNs. Our study aimed to assess the sensitivity, specificity and accuracy of FSE of SLN and to compare SLN positivity with other clinico-pathological parameters. All breast carcinoma cases having FSE of SLNs were studied for a duration of two years and were compared with permanent sections. SLN positivity was also compared with other clinico-pathological parameters. A total of 281 cases were evaluated. 88 cases were positive in FSE while 92 cases were positive in permanent sections (one false-positive and five false-negatives) with sensitivity, specificity and accuracy of 94.57%, 99.47% and 97.86% respectively. SLN positivity was significantly less in T1 tumors (17.7%; p-0.005), grade I tumors (17%; p-0.040) and in triple negative tumors (15%; p-0.041). In SLN positive cases, T1 tumors showed lesser additional ALN positivity (11.11%) comparing higher T stage tumors (35.71%). FSE of SLNs in breast carcinoma has high sensitivity and accuracy. Even though Micro metastasis and ITCs are the main source of false negative rate, they do not carry much prognostic significance. SLN positivity is significantly less in T1 tumors, grade I tumors and triple negative tumors. T1 tumors with positive SLNs showed lesser additional axillary lymph-node positivity questioning their requirement for further axillary dissection.
{"title":"Frozen section evaluation and clinicopathological correlation of sentinel lymph nodes in breast carcinoma: A study at a regional cancer centre in Western India","authors":"Jahnavi Gandhi, Karthik Dhandapani, Brindha Chandithamar, Amisha J. Gami, Ashini Shah, P. Trivedi, K. Puj","doi":"10.18231/j.ijpo.2022.033","DOIUrl":"https://doi.org/10.18231/j.ijpo.2022.033","url":null,"abstract":"Axillary lymph-node (ALN) involvement is an important prognostic factor in patients with breast carcinoma. Evaluation of Sentinel Lymph-nodes (SLN) is an accurate procedure for its assessment in the clinically node negative cases. Frozen Section Evaluation (FSE) is more widely used for intra operative evaluation of SLNs. Our study aimed to assess the sensitivity, specificity and accuracy of FSE of SLN and to compare SLN positivity with other clinico-pathological parameters. All breast carcinoma cases having FSE of SLNs were studied for a duration of two years and were compared with permanent sections. SLN positivity was also compared with other clinico-pathological parameters. A total of 281 cases were evaluated. 88 cases were positive in FSE while 92 cases were positive in permanent sections (one false-positive and five false-negatives) with sensitivity, specificity and accuracy of 94.57%, 99.47% and 97.86% respectively. SLN positivity was significantly less in T1 tumors (17.7%; p-0.005), grade I tumors (17%; p-0.040) and in triple negative tumors (15%; p-0.041). In SLN positive cases, T1 tumors showed lesser additional ALN positivity (11.11%) comparing higher T stage tumors (35.71%). FSE of SLNs in breast carcinoma has high sensitivity and accuracy. Even though Micro metastasis and ITCs are the main source of false negative rate, they do not carry much prognostic significance. SLN positivity is significantly less in T1 tumors, grade I tumors and triple negative tumors. T1 tumors with positive SLNs showed lesser additional axillary lymph-node positivity questioning their requirement for further axillary dissection.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125078360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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