Pub Date : 2022-12-15DOI: 10.18231/j.ijpo.2022.086
Saket Sharma, N. Rana
Pleomorphic xanthoastrocytoma (PXA) is a glial tumor which accounts for less than 1% of astrocytomas. PXA most commonly occurs in the temporal lobe in the outer cortex of brain and usually seen in young adults and children. As per 2020 WHO classification of CNS tumors, PXA with a mitotic activity ≥5 mitoses/10 HPF is defined as anaplastic pleomorphic xanthoastrocytoma (APXA), WHO grade 3. Here we present a rare case of Anaplastic Pleomorphic Xanthoastrocytoma developing in a female child of 11 years of age.A 11 years old female child presented with symptoms of continuous headache, giddiness, fever and vomiting since last 15 days. Computed Tomography of her brain revealed a soft tissue density mass lesion in right temporal lobe involving the insular cortex and capsuloganglionic region. The radiological differential diagnosis was a neoplastic lesion, most likely glioma. The patient underwent surgery for removal of temporal lobe tumor and the resected tumor bits were sent for histopathological assessment. Microscopically, many multinucleated lipidized giant cells were seen having eccentrically pushed nuclei, conspicuous nucleoli and abundant eosinophilic granular cytoplasm. A second population of few spindled cells with less amount of cytoplasm was also noted in the intervening parenchyma. Immunohistochemical workup showed the tumor to be positive for GFAP, S-100, Synaptophysin, p53 and CD-68. The tumor was negative for CD34. Ki-67 index was 15-20%. A final diagnosis of Anaplastic Pleomorphic Xanthoastrocytoma (grade 3) was made.APXA is a rare astrocytic tumor and has relatively more aggressive radiological and histomorphological features than pleomorphic xanthoastrocytomas and therefore it needs to be identified and treated separately.
{"title":"A pediatric case of anaplastic pleomorphic xanthoastrocytoma (Grade 3)","authors":"Saket Sharma, N. Rana","doi":"10.18231/j.ijpo.2022.086","DOIUrl":"https://doi.org/10.18231/j.ijpo.2022.086","url":null,"abstract":"Pleomorphic xanthoastrocytoma (PXA) is a glial tumor which accounts for less than 1% of astrocytomas. PXA most commonly occurs in the temporal lobe in the outer cortex of brain and usually seen in young adults and children. As per 2020 WHO classification of CNS tumors, PXA with a mitotic activity ≥5 mitoses/10 HPF is defined as anaplastic pleomorphic xanthoastrocytoma (APXA), WHO grade 3. Here we present a rare case of Anaplastic Pleomorphic Xanthoastrocytoma developing in a female child of 11 years of age.A 11 years old female child presented with symptoms of continuous headache, giddiness, fever and vomiting since last 15 days. Computed Tomography of her brain revealed a soft tissue density mass lesion in right temporal lobe involving the insular cortex and capsuloganglionic region. The radiological differential diagnosis was a neoplastic lesion, most likely glioma. The patient underwent surgery for removal of temporal lobe tumor and the resected tumor bits were sent for histopathological assessment. Microscopically, many multinucleated lipidized giant cells were seen having eccentrically pushed nuclei, conspicuous nucleoli and abundant eosinophilic granular cytoplasm. A second population of few spindled cells with less amount of cytoplasm was also noted in the intervening parenchyma. Immunohistochemical workup showed the tumor to be positive for GFAP, S-100, Synaptophysin, p53 and CD-68. The tumor was negative for CD34. Ki-67 index was 15-20%. A final diagnosis of Anaplastic Pleomorphic Xanthoastrocytoma (grade 3) was made.APXA is a rare astrocytic tumor and has relatively more aggressive radiological and histomorphological features than pleomorphic xanthoastrocytomas and therefore it needs to be identified and treated separately.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131963575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-15DOI: 10.18231/j.ijpo.2022.092
Shushruta Mohanty, Lipika Behera, Shilpa Padhi, S. Acharya
Polycystic kidney disease is a rare developmental anomaly inherited as Autosomal dominant or recessive. Autosomal recessive polycystic kidney disease (ARPKD) is an intractable cystic renal disease that results in chronic renal failure. It has a profound effect on growing fetus and result in serious implications if pregnancy is continued in the long run after being detected on sonography. Although prenatal imaging studies and clinical findings are suggestive of ARPKD it can be accurately diagnosed by histopathology if an autopsy is performed in cases of infant death. In this article we here in present the features of ARPKD diagnosed antenatally by USG in a 22 yr female, and was confirmed further by fetal autopsy.
{"title":"Autosomal recessive polycystic kidney disease (ARPKD) in fetus: Autopsy based approach","authors":"Shushruta Mohanty, Lipika Behera, Shilpa Padhi, S. Acharya","doi":"10.18231/j.ijpo.2022.092","DOIUrl":"https://doi.org/10.18231/j.ijpo.2022.092","url":null,"abstract":"Polycystic kidney disease is a rare developmental anomaly inherited as Autosomal dominant or recessive. Autosomal recessive polycystic kidney disease (ARPKD) is an intractable cystic renal disease that results in chronic renal failure. It has a profound effect on growing fetus and result in serious implications if pregnancy is continued in the long run after being detected on sonography. Although prenatal imaging studies and clinical findings are suggestive of ARPKD it can be accurately diagnosed by histopathology if an autopsy is performed in cases of infant death. In this article we here in present the features of ARPKD diagnosed antenatally by USG in a 22 yr female, and was confirmed further by fetal autopsy.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123521835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-15DOI: 10.18231/j.ijpo.2022.093
V. S. Das, V. Bhushan, Charumathy Kathireshan
Choroid plexus carcinoma is a rare aggressive malignant epithelial neoplasm (WHO grade III) arising from choroid plexus epithelium. It commonly occurs in children arising in lateral ventricles. This tumour has a tendency for recurrence and metastatic dissemination along cerebrospinal fluid (CSF) pathway. We report a case of 11 month old boy presenting with hydrocephalus, irritability and vomiting. Contrast enhanced computed tomography (CECT) brain and magnetic resonance imaging (MRI) brain with contrast revealed a mass lesion within right lateral ventricle and hydrocephalus. Surgical resection was done and the excised tissue was sent for cytology and histopathological examination and a diagnosis of choroid plexus carcinoma was made.
{"title":"Choroid plexus carcinoma: A case report","authors":"V. S. Das, V. Bhushan, Charumathy Kathireshan","doi":"10.18231/j.ijpo.2022.093","DOIUrl":"https://doi.org/10.18231/j.ijpo.2022.093","url":null,"abstract":"Choroid plexus carcinoma is a rare aggressive malignant epithelial neoplasm (WHO grade III) arising from choroid plexus epithelium. It commonly occurs in children arising in lateral ventricles. This tumour has a tendency for recurrence and metastatic dissemination along cerebrospinal fluid (CSF) pathway. We report a case of 11 month old boy presenting with hydrocephalus, irritability and vomiting. Contrast enhanced computed tomography (CECT) brain and magnetic resonance imaging (MRI) brain with contrast revealed a mass lesion within right lateral ventricle and hydrocephalus. Surgical resection was done and the excised tissue was sent for cytology and histopathological examination and a diagnosis of choroid plexus carcinoma was made.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126070936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-15DOI: 10.18231/j.ijpo.2022.090
Geethamala K, Srinivasa Murthy
Osteogenic sarcoma, a malignant mesenchymal neoplasm of long bones, has many histological variants. One such uncommon variant in which the cells have epithelioid morphology is epithelioid variant of osteosarcoma. The present case highlights the importance of knowledge for these rare variants.
{"title":"A tragic end of rare variant of osteosarcoma - A case report","authors":"Geethamala K, Srinivasa Murthy","doi":"10.18231/j.ijpo.2022.090","DOIUrl":"https://doi.org/10.18231/j.ijpo.2022.090","url":null,"abstract":"Osteogenic sarcoma, a malignant mesenchymal neoplasm of long bones, has many histological variants. One such uncommon variant in which the cells have epithelioid morphology is epithelioid variant of osteosarcoma. The present case highlights the importance of knowledge for these rare variants.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117093753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-15DOI: 10.18231/j.ijpo.2022.096
I. Jacob, Amrita Shah, P. Rangappa, Karthik Rao, N. Reddy
{"title":"Cytokine release syndrome as a consequence of check point inhibitors nivolimumab and iplimumab","authors":"I. Jacob, Amrita Shah, P. Rangappa, Karthik Rao, N. Reddy","doi":"10.18231/j.ijpo.2022.096","DOIUrl":"https://doi.org/10.18231/j.ijpo.2022.096","url":null,"abstract":"","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115369553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-15DOI: 10.18231/j.ijpo.2022.081
Chenchulakshmi Vasudevan, P. Apoorva, Adarsh C. Sanikop
Adenoid cystic carcinoma, also known as cribriform tumour or Cylindroma owing to the cellular arrangement or type of tissue that it originates from, is rare and shows perineural invasiveness as a pathognomic feature making treatment challenging. The tumour is known to arise in the salivary glands and seldom seen in the nasal cavity or paranasal sinuses. We here present a rare case of ACC occurring beyond its usual premise.A male patient aged 32 presented with unilateral nasal obstruction and epistaxis and on examination a growth in the right nasal cavity was noted to peculiarly arise from beneath the mucosa of the nasal floor, extending posteriorly up to the choana, not involving the turbinates or septum. DNE with biopsy was done and CECT PNS was done for further evaluation and the mass was diagnosed to be stage III sinonasal adenoid cystic carcinoma.This tumour originates from minor salivary glands and its presentation in the nose and paranasal sinuses has been reported to be very sparse. This is perhaps a reason for it to be missed out in daily practice due to clinical features being similar to several inflammatory and neoplastic diseases of the nose and paranasal sinuses. Histopathological cribriform and tubular subtypes are less aggressive than solid form and that determine the prognosis. It is a disease of 6th and 7th decade, slow growing and locally invasive very unusual to find it in a young patient such as ours.Though uncommon the ACC mustn’t go undiagnosed and must be differentiated from commoner nasal masses. Otorhinolaryngologists need to work in collaboration with pathologists and oncologists to accurately diagnose and treat this belligerent tumour in a multifaceted approach. Complete surgical excision with post-operative radiotherapy is the most accepted treatment plan
{"title":"A dormant yet belligerent tumour, the sinonasal adenoid cystic carcinoma- A case report","authors":"Chenchulakshmi Vasudevan, P. Apoorva, Adarsh C. Sanikop","doi":"10.18231/j.ijpo.2022.081","DOIUrl":"https://doi.org/10.18231/j.ijpo.2022.081","url":null,"abstract":"Adenoid cystic carcinoma, also known as cribriform tumour or Cylindroma owing to the cellular arrangement or type of tissue that it originates from, is rare and shows perineural invasiveness as a pathognomic feature making treatment challenging. The tumour is known to arise in the salivary glands and seldom seen in the nasal cavity or paranasal sinuses. We here present a rare case of ACC occurring beyond its usual premise.A male patient aged 32 presented with unilateral nasal obstruction and epistaxis and on examination a growth in the right nasal cavity was noted to peculiarly arise from beneath the mucosa of the nasal floor, extending posteriorly up to the choana, not involving the turbinates or septum. DNE with biopsy was done and CECT PNS was done for further evaluation and the mass was diagnosed to be stage III sinonasal adenoid cystic carcinoma.This tumour originates from minor salivary glands and its presentation in the nose and paranasal sinuses has been reported to be very sparse. This is perhaps a reason for it to be missed out in daily practice due to clinical features being similar to several inflammatory and neoplastic diseases of the nose and paranasal sinuses. Histopathological cribriform and tubular subtypes are less aggressive than solid form and that determine the prognosis. It is a disease of 6th and 7th decade, slow growing and locally invasive very unusual to find it in a young patient such as ours.Though uncommon the ACC mustn’t go undiagnosed and must be differentiated from commoner nasal masses. Otorhinolaryngologists need to work in collaboration with pathologists and oncologists to accurately diagnose and treat this belligerent tumour in a multifaceted approach. Complete surgical excision with post-operative radiotherapy is the most accepted treatment plan","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131111373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-15DOI: 10.18231/j.ijpo.2022.085
Dominic Ong, Usha Ganugapati
NUT midline carcinoma (NMC) is a rare and aggressive cancer genetically characterized by a chromosomal rearrangement of the NUT gene. Primary pulmonary NMC is even more rare. NMC typically presents with histological features of a poorly differentiated squamous cell carcinoma. We report a case of a 23-year-old female patient with NMC in the lung and pleura presented to a midsize, midwestern Canadian hospital. This article emphasizes the diagnostic challenges posed by NMC and highlights an encounter with this aggressive cancer, which had not previously been diagnosed in our health region.
{"title":"Primary pulmonary NUT midline carcinoma and its diagnostic challenges: A case report","authors":"Dominic Ong, Usha Ganugapati","doi":"10.18231/j.ijpo.2022.085","DOIUrl":"https://doi.org/10.18231/j.ijpo.2022.085","url":null,"abstract":"NUT midline carcinoma (NMC) is a rare and aggressive cancer genetically characterized by a chromosomal rearrangement of the NUT gene. Primary pulmonary NMC is even more rare. NMC typically presents with histological features of a poorly differentiated squamous cell carcinoma. We report a case of a 23-year-old female patient with NMC in the lung and pleura presented to a midsize, midwestern Canadian hospital. This article emphasizes the diagnostic challenges posed by NMC and highlights an encounter with this aggressive cancer, which had not previously been diagnosed in our health region.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"79 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132350610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-15DOI: 10.18231/j.ijpo.2022.075
O. Puvvala, D. Prakash, Vivek Nuguri, Priyanka Venkatapathappa
Breast lumps are a common cause of concern in both young and older women throughout the world. Fine needle aspiration of breast lesions is an important and widely practiced method of providing a preoperative diagnosis in women presenting with a lump in the breast. Cell blocks that are made from the aspirates help in preserving the architecture, and the nuclear morphology and help in preserving the material for immunohistochemical studies. The present study aims to highlight the role of FNAC and cell block in the diagnosis of breast lesions. This was a two-year prospective study of 72 patients presenting with palpable breast lesions referred for FNAC to the Department of Pathology JJMMC, Davangere from 1st July 2015 to 30th June 2017. After a detailed history, general physical & local examination, informed consent was taken and FNAC was performed under aseptic precautions. A part of the aspirate was fixed, then processed as cell blocks, and stained with H&E. Wherever lumpectomy or radical surgery was performed the histopathology was correlated with cytomorphological findings.: The present study showed a diagnostic accuracy of 85.71% in the FNAC diagnosis. The sensitivity and specificity of FNAC in diagnosing breast lesions were found to be 82.60% and 87.23%. PPV and NPV were 76% and 91.11% respectively. When cell blocks were used the diagnostic accuracy increased to 88.57%. Diagnosis by using cell block showed a sensitivity of 79% specificity of 93.47%, PPV of 86.36%, and NPV of 89.58%.: From the results of our study, it can be concluded that the accuracy of diagnosing breast lesions preoperatively can be increased when FNAC is combined with the cell blocks from the aspirates. The cell blocks also help to preserve the aspirated material for future reference and immunohistochemistry can also be applied for a more accurate diagnosis.
{"title":"Advantages of the cell block technique over the FNAC and correlation with histopathology of most prevalent breast lesions in the community at the tertiary care center","authors":"O. Puvvala, D. Prakash, Vivek Nuguri, Priyanka Venkatapathappa","doi":"10.18231/j.ijpo.2022.075","DOIUrl":"https://doi.org/10.18231/j.ijpo.2022.075","url":null,"abstract":"Breast lumps are a common cause of concern in both young and older women throughout the world. Fine needle aspiration of breast lesions is an important and widely practiced method of providing a preoperative diagnosis in women presenting with a lump in the breast. Cell blocks that are made from the aspirates help in preserving the architecture, and the nuclear morphology and help in preserving the material for immunohistochemical studies. The present study aims to highlight the role of FNAC and cell block in the diagnosis of breast lesions. This was a two-year prospective study of 72 patients presenting with palpable breast lesions referred for FNAC to the Department of Pathology JJMMC, Davangere from 1st July 2015 to 30th June 2017. After a detailed history, general physical & local examination, informed consent was taken and FNAC was performed under aseptic precautions. A part of the aspirate was fixed, then processed as cell blocks, and stained with H&E. Wherever lumpectomy or radical surgery was performed the histopathology was correlated with cytomorphological findings.: The present study showed a diagnostic accuracy of 85.71% in the FNAC diagnosis. The sensitivity and specificity of FNAC in diagnosing breast lesions were found to be 82.60% and 87.23%. PPV and NPV were 76% and 91.11% respectively. When cell blocks were used the diagnostic accuracy increased to 88.57%. Diagnosis by using cell block showed a sensitivity of 79% specificity of 93.47%, PPV of 86.36%, and NPV of 89.58%.: From the results of our study, it can be concluded that the accuracy of diagnosing breast lesions preoperatively can be increased when FNAC is combined with the cell blocks from the aspirates. The cell blocks also help to preserve the aspirated material for future reference and immunohistochemistry can also be applied for a more accurate diagnosis.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126509266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-15DOI: 10.18231/j.ijpo.2022.095
S. Raj
The principal guidelines of healthcare ethics is first & foremost is that the patient’s welfare is paramount. Personnel working in clinical and/or research laboratories or engaged in biomedical sciences or research should be aware of their ethical responsibilities & comply with the ethical code of conduct all laboratories follow quality guidelines & maintain proper documentation. Corrective and Preventive Action(CAPA) is the key to maintain quality of testing & to prevent any medical negligence & report descrepancies. Henceforth, Clinical/Research laboratories should try to avoid circumstances or situations that give rise to a conflict of interest & unlawful act.
{"title":"Quality improvement & ethical issues in laboratory medicine","authors":"S. Raj","doi":"10.18231/j.ijpo.2022.095","DOIUrl":"https://doi.org/10.18231/j.ijpo.2022.095","url":null,"abstract":"The principal guidelines of healthcare ethics is first & foremost is that the patient’s welfare is paramount. Personnel working in clinical and/or research laboratories or engaged in biomedical sciences or research should be aware of their ethical responsibilities & comply with the ethical code of conduct all laboratories follow quality guidelines & maintain proper documentation. Corrective and Preventive Action(CAPA) is the key to maintain quality of testing & to prevent any medical negligence & report descrepancies. Henceforth, Clinical/Research laboratories should try to avoid circumstances or situations that give rise to a conflict of interest & unlawful act.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121622624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-15DOI: 10.18231/j.ijpo.2022.080
Anju Bansal, M. Kaur, G. Singh, R. Mohil
Clear cell sarcomas are rare tumours accounting for less than 1% of all soft tissue tumours. They are aggressive lesions with extremely poor prognosis. The clinical diagnosis of this tumour is challenging, requiring histopathologic examination for definite characterization. The treatment protocol for this tumour is not well-established, with most studies showing no clear cut role of chemoradiation. This is a case of clear cell sarcoma of soft tissue in a 57-year-old male who presented with a solid-cystic mass on the thigh and was diagnosed as hematoma clinicoradiologically. Post-operative residual tumour was treated successfully with radio/chemotherapy, in a manner similar to melanoma. This article, thus, also highlights the role of chemoradiation in the treatment of clear cell sarcoma, suggesting that it can be better treated like melanoma rather than like a soft tissue sarcoma.
{"title":"Recurrent clear cell sarcoma and its responsiveness to chemoradiation","authors":"Anju Bansal, M. Kaur, G. Singh, R. Mohil","doi":"10.18231/j.ijpo.2022.080","DOIUrl":"https://doi.org/10.18231/j.ijpo.2022.080","url":null,"abstract":"Clear cell sarcomas are rare tumours accounting for less than 1% of all soft tissue tumours. They are aggressive lesions with extremely poor prognosis. The clinical diagnosis of this tumour is challenging, requiring histopathologic examination for definite characterization. The treatment protocol for this tumour is not well-established, with most studies showing no clear cut role of chemoradiation. This is a case of clear cell sarcoma of soft tissue in a 57-year-old male who presented with a solid-cystic mass on the thigh and was diagnosed as hematoma clinicoradiologically. Post-operative residual tumour was treated successfully with radio/chemotherapy, in a manner similar to melanoma. This article, thus, also highlights the role of chemoradiation in the treatment of clear cell sarcoma, suggesting that it can be better treated like melanoma rather than like a soft tissue sarcoma.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117169375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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